---
_id: '9349'
abstract:
- lang: eng
  text: 'The way in which interactions between mechanics and biochemistry lead to
    the emergence of complex cell and tissue organization is an old question that
    has recently attracted renewed interest from biologists, physicists, mathematicians
    and computer scientists. Rapid advances in optical physics, microscopy and computational
    image analysis have greatly enhanced our ability to observe and quantify spatiotemporal
    patterns of signalling, force generation, deformation, and flow in living cells
    and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation
    are allowing us to perturb the underlying machinery that generates these patterns
    in increasingly sophisticated ways. Rapid advances in theory and computing have
    made it possible to construct predictive models that describe how cell and tissue
    organization and dynamics emerge from the local coupling of biochemistry and mechanics.
    Together, these advances have opened up a wealth of new opportunities to explore
    how mechanochemical patterning shapes organismal development. In this roadmap,
    we present a series of forward-looking case studies on mechanochemical patterning
    in development, written by scientists working at the interface between the physical
    and biological sciences, and covering a wide range of spatial and temporal scales,
    organisms, and modes of development. Together, these contributions highlight the
    many ways in which the dynamic coupling of mechanics and biochemistry shapes biological
    dynamics: from mechanoenzymes that sense force to tune their activity and motor
    output, to collectives of cells in tissues that flow and redistribute biochemical
    signals during development.'
acknowledgement: The AK group is supported by IST Austria and by the ERC under European
  Union Horizon 2020 research and innovation programme Grant 680037. Apologies to
  those whose work could not be mentioned due to limited space. We thank all my lab
  members, both past and present, for stimulating discussion. This work was funded
  by a Singapore Ministry of Education Tier 3 Grant, MOE2016-T3-1-005. We thank Francis
  Corson for continuous discussion and collaboration contributing to these views and
  for figure 4(A). PC is sponsored by the Institut Pasteur and the European Union's
  Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie
  Grant Agreement No. 665807. Research in JG's laboratory is funded by the European
  Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC
  Grant Agreement No. 337635, Institut Pasteur, CNRS, Cercle FSER, Fondation pour
  la Recherche Medicale, the Vallee Foundation and the ANR-19-CE-13-0024 Grant. We
  thank Erez Braun and Alex Mogilner for comments on the manuscript and Niv Ierushalmi
  for help with figure 5. This project has received funding from the European Union's
  Horizon 2020 research and innovation programme under Grant Agreement No. ERC-2018-COG
  Grant 819174-HydraMechanics awarded to KK. EH thanks all lab members, as well as
  Pierre Recho, Tsuyoshi Hirashima, Diana Pinheiro and Carl-Philip Heisenberg, for
  fruitful discussions on these topics—and apologize for not being able to cite many
  very relevant publications due to the strict 10-reference limit. EH acknowledges
  the support of Austrian Science Fund (FWF) (P 31639) and the European Research Council
  under the European Union's Horizon 2020 Research and Innovation Programme Grant
  Agreements (851288). The authors acknowledge the inspiring scientists whose work
  could not be cited in this perspective due to space constraints; the members of
  the Gartner Lab for helpful discussions; the Barbara and Gerson Bakar Foundation,
  the Chan Zuckerberg Biohub Investigators Programme, the National Institute of Health,
  and the Centre for Cellular Construction, an NSF Science and Technology Centre.
  The Minc laboratory is currently funded by the CNRS and the European Research Council
  (CoG Forcaster No. 647073). Research in the lab of J-LM is supported by the Institut
  Curie, the Centre National de la Recherche Scientifique (CNRS), the Institut National
  de la Santé Et de la Recherche Médicale (INSERM), and is funded by grants from the
  ATIP-Avenir programme, the Fondation Schlumberger pour l'Éducation et la Recherche
  via the Fondation pour la Recherche Médicale, the European Research Council Starting
  Grant ERC-2017-StG 757557, the European Molecular Biology Organization Young Investigator
  programme (EMBO YIP), the INSERM transversal programme Human Development Cell Atlas
  (HuDeCA), Paris Sciences Lettres (PSL) 'nouvelle équipe' and QLife (17-CONV-0005)
  grants and Labex DEEP (ANR-11-LABX-0044) which are part of the IDEX PSL (ANR-10-IDEX-0001-02).
  We acknowledge useful discussions with Massimo Vergassola, Sebastian Streichan and
  my lab members. Work in my laboratory on Drosophila embryogenesis is partly supported
  by NIH-R01GM122936. The authors acknowledge the support by a grant from the European
  Research Council (Grant No. 682161). Lenne group is funded by a grant from the 'Investissements
  d'Avenir' French Government programme managed by the French National Research Agency
  (ANR-16-CONV-0001) and by the Excellence Initiative of Aix-Marseille University—A*MIDEX,
  and ANR projects MechaResp (ANR-17-CE13-0032) and AdGastrulo (ANR-19-CE13-0022).
article_number: '041501'
article_processing_charge: No
article_type: original
author:
- first_name: Pierre François
  full_name: Lenne, Pierre François
  last_name: Lenne
- first_name: Edwin
  full_name: Munro, Edwin
  last_name: Munro
- first_name: Idse
  full_name: Heemskerk, Idse
  last_name: Heemskerk
- first_name: Aryeh
  full_name: Warmflash, Aryeh
  last_name: Warmflash
- first_name: Laura
  full_name: Bocanegra, Laura
  id: 4896F754-F248-11E8-B48F-1D18A9856A87
  last_name: Bocanegra
- first_name: Kasumi
  full_name: Kishi, Kasumi
  id: 3065DFC4-F248-11E8-B48F-1D18A9856A87
  last_name: Kishi
- first_name: Anna
  full_name: Kicheva, Anna
  id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
  last_name: Kicheva
  orcid: 0000-0003-4509-4998
- first_name: Yuchen
  full_name: Long, Yuchen
  last_name: Long
- first_name: Antoine
  full_name: Fruleux, Antoine
  last_name: Fruleux
- first_name: Arezki
  full_name: Boudaoud, Arezki
  last_name: Boudaoud
- first_name: Timothy E.
  full_name: Saunders, Timothy E.
  last_name: Saunders
- first_name: Paolo
  full_name: Caldarelli, Paolo
  last_name: Caldarelli
- first_name: Arthur
  full_name: Michaut, Arthur
  last_name: Michaut
- first_name: Jerome
  full_name: Gros, Jerome
  last_name: Gros
- first_name: Yonit
  full_name: Maroudas-Sacks, Yonit
  last_name: Maroudas-Sacks
- first_name: Kinneret
  full_name: Keren, Kinneret
  last_name: Keren
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Zev J.
  full_name: Gartner, Zev J.
  last_name: Gartner
- first_name: Benjamin
  full_name: Stormo, Benjamin
  last_name: Stormo
- first_name: Amy
  full_name: Gladfelter, Amy
  last_name: Gladfelter
- first_name: Alan
  full_name: Rodrigues, Alan
  last_name: Rodrigues
- first_name: Amy
  full_name: Shyer, Amy
  last_name: Shyer
- first_name: Nicolas
  full_name: Minc, Nicolas
  last_name: Minc
- first_name: Jean Léon
  full_name: Maître, Jean Léon
  last_name: Maître
- first_name: Stefano
  full_name: Di Talia, Stefano
  last_name: Di Talia
- first_name: Bassma
  full_name: Khamaisi, Bassma
  last_name: Khamaisi
- first_name: David
  full_name: Sprinzak, David
  last_name: Sprinzak
- first_name: Sham
  full_name: Tlili, Sham
  last_name: Tlili
citation:
  ama: Lenne PF, Munro E, Heemskerk I, et al. Roadmap for the multiscale coupling
    of biochemical and mechanical signals during development. <i>Physical biology</i>.
    2021;18(4). doi:<a href="https://doi.org/10.1088/1478-3975/abd0db">10.1088/1478-3975/abd0db</a>
  apa: Lenne, P. F., Munro, E., Heemskerk, I., Warmflash, A., Bocanegra, L., Kishi,
    K., … Tlili, S. (2021). Roadmap for the multiscale coupling of biochemical and
    mechanical signals during development. <i>Physical Biology</i>. IOP Publishing.
    <a href="https://doi.org/10.1088/1478-3975/abd0db">https://doi.org/10.1088/1478-3975/abd0db</a>
  chicago: Lenne, Pierre François, Edwin Munro, Idse Heemskerk, Aryeh Warmflash, Laura
    Bocanegra, Kasumi Kishi, Anna Kicheva, et al. “Roadmap for the Multiscale Coupling
    of Biochemical and Mechanical Signals during Development.” <i>Physical Biology</i>.
    IOP Publishing, 2021. <a href="https://doi.org/10.1088/1478-3975/abd0db">https://doi.org/10.1088/1478-3975/abd0db</a>.
  ieee: P. F. Lenne <i>et al.</i>, “Roadmap for the multiscale coupling of biochemical
    and mechanical signals during development,” <i>Physical biology</i>, vol. 18,
    no. 4. IOP Publishing, 2021.
  ista: Lenne PF, Munro E, Heemskerk I, Warmflash A, Bocanegra L, Kishi K, Kicheva
    A, Long Y, Fruleux A, Boudaoud A, Saunders TE, Caldarelli P, Michaut A, Gros J,
    Maroudas-Sacks Y, Keren K, Hannezo EB, Gartner ZJ, Stormo B, Gladfelter A, Rodrigues
    A, Shyer A, Minc N, Maître JL, Di Talia S, Khamaisi B, Sprinzak D, Tlili S. 2021.
    Roadmap for the multiscale coupling of biochemical and mechanical signals during
    development. Physical biology. 18(4), 041501.
  mla: Lenne, Pierre François, et al. “Roadmap for the Multiscale Coupling of Biochemical
    and Mechanical Signals during Development.” <i>Physical Biology</i>, vol. 18,
    no. 4, 041501, IOP Publishing, 2021, doi:<a href="https://doi.org/10.1088/1478-3975/abd0db">10.1088/1478-3975/abd0db</a>.
  short: P.F. Lenne, E. Munro, I. Heemskerk, A. Warmflash, L. Bocanegra, K. Kishi,
    A. Kicheva, Y. Long, A. Fruleux, A. Boudaoud, T.E. Saunders, P. Caldarelli, A.
    Michaut, J. Gros, Y. Maroudas-Sacks, K. Keren, E.B. Hannezo, Z.J. Gartner, B.
    Stormo, A. Gladfelter, A. Rodrigues, A. Shyer, N. Minc, J.L. Maître, S. Di Talia,
    B. Khamaisi, D. Sprinzak, S. Tlili, Physical Biology 18 (2021).
date_created: 2021-04-25T22:01:29Z
date_published: 2021-04-14T00:00:00Z
date_updated: 2023-08-08T13:15:46Z
day: '14'
ddc:
- '570'
department:
- _id: AnKi
- _id: EdHa
doi: 10.1088/1478-3975/abd0db
ec_funded: 1
external_id:
  isi:
  - '000640396400001'
  pmid:
  - '33276350'
file:
- access_level: open_access
  checksum: 4f52082549d3561c4c15d4d8d84ca5d8
  content_type: application/pdf
  creator: cziletti
  date_created: 2021-04-27T08:38:35Z
  date_updated: 2021-04-27T08:38:35Z
  file_id: '9355'
  file_name: 2021_PhysBio_Lenne.pdf
  file_size: 6296324
  relation: main_file
  success: 1
file_date_updated: 2021-04-27T08:38:35Z
has_accepted_license: '1'
intvolume: '        18'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
  call_identifier: H2020
  grant_number: '680037'
  name: Coordination of Patterning And Growth In the Spinal Cord
- _id: 268294B6-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P31639
  name: Active mechano-chemical description of the cell cytoskeleton
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '851288'
  name: Design Principles of Branching Morphogenesis
publication: Physical biology
publication_identifier:
  eissn:
  - 1478-3975
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
related_material:
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    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Roadmap for the multiscale coupling of biochemical and mechanical signals during
  development
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 18
year: '2021'
...
---
_id: '8220'
abstract:
- lang: eng
  text: Understanding to what extent stem cell potential is a cell-intrinsic property
    or an emergent behavior coming from global tissue dynamics and geometry is a key
    outstanding question of systems and stem cell biology. Here, we propose a theory
    of stem cell dynamics as a stochastic competition for access to a spatially localized
    niche, giving rise to a stochastic conveyor-belt model. Cell divisions produce
    a steady cellular stream which advects cells away from the niche, while random
    rearrangements enable cells away from the niche to be favorably repositioned.
    Importantly, even when assuming that all cells in a tissue are molecularly equivalent,
    we predict a common (“universal”) functional dependence of the long-term clonal
    survival probability on distance from the niche, as well as the emergence of a
    well-defined number of functional stem cells, dependent only on the rate of random
    movements vs. mitosis-driven advection. We test the predictions of this theory
    on datasets of pubertal mammary gland tips and embryonic kidney tips, as well
    as homeostatic intestinal crypts. Importantly, we find good agreement for the
    predicted functional dependency of the competition as a function of position,
    and thus functional stem cell number in each organ. This argues for a key role
    of positional fluctuations in dictating stem cell number and dynamics, and we
    discuss the applicability of this theory to other settings.
acknowledgement: "We thank all members of the E.H., B.D.S., and J.v.R. groups for
  stimulating discussions. This project was supported by\r\nthe European Research
  Council (648804 to J.v.R. and 851288 to E.H.). It has also received support from
  the CancerGenomics.nl (Netherlands Organization for Scientific Research) program
  (J.v.R.) and the Doctor Josef Steiner Foundation (J.v.R). B.D.S. was supported by
  Royal Society E. P. Abraham Research Professorship RP/R1/180165 and Wellcome Trust
  Grant 098357/Z/12/Z."
article_processing_charge: No
article_type: original
author:
- first_name: Bernat
  full_name: Corominas-Murtra, Bernat
  id: 43BE2298-F248-11E8-B48F-1D18A9856A87
  last_name: Corominas-Murtra
  orcid: 0000-0001-9806-5643
- first_name: Colinda L.G.J.
  full_name: Scheele, Colinda L.G.J.
  last_name: Scheele
- first_name: Kasumi
  full_name: Kishi, Kasumi
  id: 3065DFC4-F248-11E8-B48F-1D18A9856A87
  last_name: Kishi
- first_name: Saskia I.J.
  full_name: Ellenbroek, Saskia I.J.
  last_name: Ellenbroek
- first_name: Benjamin D.
  full_name: Simons, Benjamin D.
  last_name: Simons
- first_name: Jacco
  full_name: Van Rheenen, Jacco
  last_name: Van Rheenen
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
citation:
  ama: Corominas-Murtra B, Scheele CLGJ, Kishi K, et al. Stem cell lineage survival
    as a noisy competition for niche access. <i>Proceedings of the National Academy
    of Sciences of the United States of America</i>. 2020;117(29):16969-16975. doi:<a
    href="https://doi.org/10.1073/pnas.1921205117">10.1073/pnas.1921205117</a>
  apa: Corominas-Murtra, B., Scheele, C. L. G. J., Kishi, K., Ellenbroek, S. I. J.,
    Simons, B. D., Van Rheenen, J., &#38; Hannezo, E. B. (2020). Stem cell lineage
    survival as a noisy competition for niche access. <i>Proceedings of the National
    Academy of Sciences of the United States of America</i>. National Academy of Sciences.
    <a href="https://doi.org/10.1073/pnas.1921205117">https://doi.org/10.1073/pnas.1921205117</a>
  chicago: Corominas-Murtra, Bernat, Colinda L.G.J. Scheele, Kasumi Kishi, Saskia
    I.J. Ellenbroek, Benjamin D. Simons, Jacco Van Rheenen, and Edouard B Hannezo.
    “Stem Cell Lineage Survival as a Noisy Competition for Niche Access.” <i>Proceedings
    of the National Academy of Sciences of the United States of America</i>. National
    Academy of Sciences, 2020. <a href="https://doi.org/10.1073/pnas.1921205117">https://doi.org/10.1073/pnas.1921205117</a>.
  ieee: B. Corominas-Murtra <i>et al.</i>, “Stem cell lineage survival as a noisy
    competition for niche access,” <i>Proceedings of the National Academy of Sciences
    of the United States of America</i>, vol. 117, no. 29. National Academy of Sciences,
    pp. 16969–16975, 2020.
  ista: Corominas-Murtra B, Scheele CLGJ, Kishi K, Ellenbroek SIJ, Simons BD, Van
    Rheenen J, Hannezo EB. 2020. Stem cell lineage survival as a noisy competition
    for niche access. Proceedings of the National Academy of Sciences of the United
    States of America. 117(29), 16969–16975.
  mla: Corominas-Murtra, Bernat, et al. “Stem Cell Lineage Survival as a Noisy Competition
    for Niche Access.” <i>Proceedings of the National Academy of Sciences of the United
    States of America</i>, vol. 117, no. 29, National Academy of Sciences, 2020, pp.
    16969–75, doi:<a href="https://doi.org/10.1073/pnas.1921205117">10.1073/pnas.1921205117</a>.
  short: B. Corominas-Murtra, C.L.G.J. Scheele, K. Kishi, S.I.J. Ellenbroek, B.D.
    Simons, J. Van Rheenen, E.B. Hannezo, Proceedings of the National Academy of Sciences
    of the United States of America 117 (2020) 16969–16975.
date_created: 2020-08-09T22:00:52Z
date_published: 2020-07-21T00:00:00Z
date_updated: 2023-08-22T08:29:30Z
day: '21'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1073/pnas.1921205117
ec_funded: 1
external_id:
  isi:
  - '000553292900014'
  pmid:
  - '32611816'
file:
- access_level: open_access
  content_type: application/pdf
  creator: dernst
  date_created: 2020-08-10T06:50:28Z
  date_updated: 2020-08-10T06:50:28Z
  file_id: '8223'
  file_name: 2020_PNAS_Corominas.pdf
  file_size: 1111604
  relation: main_file
  success: 1
file_date_updated: 2020-08-10T06:50:28Z
has_accepted_license: '1'
intvolume: '       117'
isi: 1
issue: '29'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 16969-16975
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
  call_identifier: H2020
  grant_number: '851288'
  name: Design Principles of Branching Morphogenesis
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  eissn:
  - '10916490'
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
related_material:
  link:
  - relation: press_release
    url: https://ist.ac.at/en/news/order-from-noise/
scopus_import: '1'
status: public
title: Stem cell lineage survival as a noisy competition for niche access
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 117
year: '2020'
...
---
_id: '3'
abstract:
- lang: eng
  text: SETD5 gene mutations have been identified as a frequent cause of idiopathic
    intellectual disability. Here we show that Setd5-haploinsufficient mice present
    developmental defects such as abnormal brain-to-body weight ratios and neural
    crest defect-associated phenotypes. Furthermore, Setd5-mutant mice show impairments
    in cognitive tasks, enhanced long-term potentiation, delayed ontogenetic profile
    of ultrasonic vocalization, and behavioral inflexibility. Behavioral issues are
    accompanied by abnormal expression of postsynaptic density proteins previously
    associated with cognition. Our data additionally indicate that Setd5 regulates
    RNA polymerase II dynamics and gene transcription via its interaction with the
    Hdac3 and Paf1 complexes, findings potentially explaining the gene expression
    defects observed in Setd5-haploinsufficient mice. Our results emphasize the decisive
    role of Setd5 in a biological pathway found to be disrupted in humans with intellectual
    disability and autism spectrum disorder.
acknowledged_ssus:
- _id: M-Shop
- _id: PreCl
acknowledgement: This work was supported by the Simons Foundation Autism Research
  Initiative (grant 401299) to G.N. and the DFG (SPP1738 grant NO 1249) to K.-M.N.
article_processing_charge: No
article_type: original
author:
- first_name: Elena
  full_name: Deliu, Elena
  id: 37A40D7E-F248-11E8-B48F-1D18A9856A87
  last_name: Deliu
  orcid: 0000-0002-7370-5293
- first_name: Niccoló
  full_name: Arecco, Niccoló
  last_name: Arecco
- first_name: Jasmin
  full_name: Morandell, Jasmin
  id: 4739D480-F248-11E8-B48F-1D18A9856A87
  last_name: Morandell
- first_name: Christoph
  full_name: Dotter, Christoph
  id: 4C66542E-F248-11E8-B48F-1D18A9856A87
  last_name: Dotter
  orcid: 0000-0002-9033-9096
- first_name: Ximena
  full_name: Contreras, Ximena
  id: 475990FE-F248-11E8-B48F-1D18A9856A87
  last_name: Contreras
- first_name: Charles
  full_name: Girardot, Charles
  last_name: Girardot
- first_name: Eva
  full_name: Käsper, Eva
  last_name: Käsper
- first_name: Alena
  full_name: Kozlova, Alena
  id: C50A9596-02D0-11E9-976E-E38CFE5CBC1D
  last_name: Kozlova
- first_name: Kasumi
  full_name: Kishi, Kasumi
  id: 3065DFC4-F248-11E8-B48F-1D18A9856A87
  last_name: Kishi
- first_name: Ilaria
  full_name: Chiaradia, Ilaria
  id: B6467F20-02D0-11E9-BDA5-E960C241894A
  last_name: Chiaradia
  orcid: 0000-0002-9529-4464
- first_name: Kyung
  full_name: Noh, Kyung
  last_name: Noh
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
citation:
  ama: Deliu E, Arecco N, Morandell J, et al. Haploinsufficiency of the intellectual
    disability gene SETD5 disturbs developmental gene expression and cognition. <i>Nature
    Neuroscience</i>. 2018;21(12):1717-1727. doi:<a href="https://doi.org/10.1038/s41593-018-0266-2">10.1038/s41593-018-0266-2</a>
  apa: Deliu, E., Arecco, N., Morandell, J., Dotter, C., Contreras, X., Girardot,
    C., … Novarino, G. (2018). Haploinsufficiency of the intellectual disability gene
    SETD5 disturbs developmental gene expression and cognition. <i>Nature Neuroscience</i>.
    Nature Publishing Group. <a href="https://doi.org/10.1038/s41593-018-0266-2">https://doi.org/10.1038/s41593-018-0266-2</a>
  chicago: Deliu, Elena, Niccoló Arecco, Jasmin Morandell, Christoph Dotter, Ximena
    Contreras, Charles Girardot, Eva Käsper, et al. “Haploinsufficiency of the Intellectual
    Disability Gene SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature
    Neuroscience</i>. Nature Publishing Group, 2018. <a href="https://doi.org/10.1038/s41593-018-0266-2">https://doi.org/10.1038/s41593-018-0266-2</a>.
  ieee: E. Deliu <i>et al.</i>, “Haploinsufficiency of the intellectual disability
    gene SETD5 disturbs developmental gene expression and cognition,” <i>Nature Neuroscience</i>,
    vol. 21, no. 12. Nature Publishing Group, pp. 1717–1727, 2018.
  ista: Deliu E, Arecco N, Morandell J, Dotter C, Contreras X, Girardot C, Käsper
    E, Kozlova A, Kishi K, Chiaradia I, Noh K, Novarino G. 2018. Haploinsufficiency
    of the intellectual disability gene SETD5 disturbs developmental gene expression
    and cognition. Nature Neuroscience. 21(12), 1717–1727.
  mla: Deliu, Elena, et al. “Haploinsufficiency of the Intellectual Disability Gene
    SETD5 Disturbs Developmental Gene Expression and Cognition.” <i>Nature Neuroscience</i>,
    vol. 21, no. 12, Nature Publishing Group, 2018, pp. 1717–27, doi:<a href="https://doi.org/10.1038/s41593-018-0266-2">10.1038/s41593-018-0266-2</a>.
  short: E. Deliu, N. Arecco, J. Morandell, C. Dotter, X. Contreras, C. Girardot,
    E. Käsper, A. Kozlova, K. Kishi, I. Chiaradia, K. Noh, G. Novarino, Nature Neuroscience
    21 (2018) 1717–1727.
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