[{"year":"2024","external_id":{"pmid":["38307022"]},"publication":"Current Biology","status":"public","pmid":1,"date_published":"2024-02-26T00:00:00Z","acknowledgement":"We are sincerely grateful to the referees for their valuable comments and suggestions, which helped us to improve the paper. We are thankful to Jorgen Eilenberg and Nicolai V. Meyling for the fungal strain, to Simon Tragust, Abel Bernadou, and Brian Lazarro for insightful discussions, to Iago Sanmartín-Villar, Léa Briard, Céline Maitrel, and Nolwenn Rissen for their help with the experiments. Furthermore, we thank Anna V. Grasse for help with the immune gene expression analyses. We thank Sergio Ibarra for creating the graphical abstract. E.C. was supported by a Fyssen Foundation grant and the Alexander von Humboldt Foundation. A.D. was supported by the CNRS.","article_processing_charge":"No","doi":"10.1016/j.cub.2024.01.017","publisher":"Elsevier","dataavailabilitystatement":"no DAS","_id":"14479","date_updated":"2026-03-18T11:15:21Z","type":"journal_article","page":"902-909.e6","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2023.10.26.564092"}],"quality_controlled":"1","month":"02","department":[{"_id":"SyCr"}],"oa":1,"language":[{"iso":"eng"}],"researchdata_availability":"unclear","citation":{"apa":"Csata, E., Perez-Escudero, A., Laury, E., Leitner, H., Latil, G., Heinze, J., … Dussutour, A. (2024). Fungal infection alters collective nutritional intake of ant colonies. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2024.01.017\">https://doi.org/10.1016/j.cub.2024.01.017</a>","mla":"Csata, Eniko, et al. “Fungal Infection Alters Collective Nutritional Intake of Ant Colonies.” <i>Current Biology</i>, vol. 34, no. 4, Elsevier, 2024, p. 902–909.e6, doi:<a href=\"https://doi.org/10.1016/j.cub.2024.01.017\">10.1016/j.cub.2024.01.017</a>.","chicago":"Csata, Eniko, Alfonso Perez-Escudero, Emmanuel Laury, Hanna Leitner, Gerard Latil, Juerge Heinze, Stephen Simpson, Sylvia Cremer, and Audrey Dussutour. “Fungal Infection Alters Collective Nutritional Intake of Ant Colonies.” <i>Current Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.cub.2024.01.017\">https://doi.org/10.1016/j.cub.2024.01.017</a>.","ista":"Csata E, Perez-Escudero A, Laury E, Leitner H, Latil G, Heinze J, Simpson S, Cremer S, Dussutour A. 2024. Fungal infection alters collective nutritional intake of ant colonies. Current Biology. 34(4), 902–909.e6.","ieee":"E. Csata <i>et al.</i>, “Fungal infection alters collective nutritional intake of ant colonies,” <i>Current Biology</i>, vol. 34, no. 4. Elsevier, p. 902–909.e6, 2024.","short":"E. Csata, A. Perez-Escudero, E. Laury, H. Leitner, G. Latil, J. Heinze, S. Simpson, S. Cremer, A. Dussutour, Current Biology 34 (2024) 902–909.e6.","ama":"Csata E, Perez-Escudero A, Laury E, et al. Fungal infection alters collective nutritional intake of ant colonies. <i>Current Biology</i>. 2024;34(4):902-909.e6. doi:<a href=\"https://doi.org/10.1016/j.cub.2024.01.017\">10.1016/j.cub.2024.01.017</a>"},"supplementarymaterial":"yes","issue":"4","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","scopus_import":"1","day":"26","author":[{"last_name":"Csata","full_name":"Csata, Eniko","first_name":"Eniko"},{"last_name":"Perez-Escudero","full_name":"Perez-Escudero, Alfonso","first_name":"Alfonso"},{"full_name":"Laury, Emmanuel","last_name":"Laury","first_name":"Emmanuel"},{"first_name":"Hanna","full_name":"Leitner, Hanna","id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","last_name":"Leitner"},{"last_name":"Latil","full_name":"Latil, Gerard","first_name":"Gerard"},{"full_name":"Heinze, Juerge","last_name":"Heinze","first_name":"Juerge"},{"first_name":"Stephen","last_name":"Simpson","full_name":"Simpson, Stephen"},{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia"},{"first_name":"Audrey","last_name":"Dussutour","full_name":"Dussutour, Audrey"}],"oa_version":"Preprint","title":"Fungal infection alters collective nutritional intake of ant colonies","volume":34,"date_created":"2023-10-31T13:30:20Z","article_type":"original","intvolume":"        34","abstract":[{"text":"In animals, parasitic infections impose significant fitness costs.1,2,3,4,5,6 Infected animals can alter their feeding behavior to resist infection,7,8,9,10,11,12 but parasites can manipulate animal foraging behavior to their own benefits.13,14,15,16 How nutrition influences host-parasite interactions is not well understood, as studies have mainly focused on the host and less on the parasite.9,12,17,18,19,20,21,22,23 We used the nutritional geometry framework24 to investigate the role of amino acids (AA) and carbohydrates (C) in a host-parasite system: the Argentine ant, Linepithema humile, and the entomopathogenic fungus, Metarhizium brunneum. First, using 18 diets varying in AA:C composition, we established that the fungus performed best on the high-amino-acid diet 1:4. Second, we found that the fungus reached this optimal diet when given various diet pairings, revealing its ability to cope with nutritional challenges. Third, we showed that the optimal fungal diet reduced the lifespan of healthy ants when compared with a high-carbohydrate diet but had no effect on infected ants. Fourth, we revealed that infected ant colonies, given a choice between the optimal fungal diet and a high-carbohydrate diet, chose the optimal fungal diet, whereas healthy colonies avoided it. Lastly, by disentangling fungal infection from host immune response, we demonstrated that infected ants foraged on the optimal fungal diet in response to immune activation and not as a result of parasite manipulation. Therefore, we revealed that infected ant colonies chose a diet that is costly for survival in the long term but beneficial in the short term—a form of collective self-medication.","lang":"eng"}],"publication_identifier":{"eissn":["1879-0445"],"issnl":["1234-5678"],"issn":["0960-9822"]},"publication_status":"published"},{"department":[{"_id":"SyCr"}],"year":"2023","month":"09","ec_funded":1,"citation":{"apa":"Habig, M., Grasse, A. V., Müller, J., Stukenbrock, E. H., Leitner, H., &#38; Cremer, S. (n.d.). Frequent horizontal chromosome transfer between asexual fungal insect pathogens. <i>bioRxiv</i>. <a href=\"https://doi.org/10.1101/2023.09.18.558174\">https://doi.org/10.1101/2023.09.18.558174</a>","mla":"Habig, Michael, et al. “Frequent Horizontal Chromosome Transfer between Asexual Fungal Insect Pathogens.” <i>BioRxiv</i>, doi:<a href=\"https://doi.org/10.1101/2023.09.18.558174\">10.1101/2023.09.18.558174</a>.","chicago":"Habig, Michael, Anna V Grasse, Judith Müller, Eva H. Stukenbrock, Hanna Leitner, and Sylvia Cremer. “Frequent Horizontal Chromosome Transfer between Asexual Fungal Insect Pathogens.” <i>BioRxiv</i>, n.d. <a href=\"https://doi.org/10.1101/2023.09.18.558174\">https://doi.org/10.1101/2023.09.18.558174</a>.","ista":"Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. Frequent horizontal chromosome transfer between asexual fungal insect pathogens. bioRxiv, <a href=\"https://doi.org/10.1101/2023.09.18.558174\">10.1101/2023.09.18.558174</a>.","ieee":"M. Habig, A. V. Grasse, J. Müller, E. H. Stukenbrock, H. Leitner, and S. Cremer, “Frequent horizontal chromosome transfer between asexual fungal insect pathogens,” <i>bioRxiv</i>. .","short":"M. Habig, A.V. Grasse, J. Müller, E.H. Stukenbrock, H. Leitner, S. Cremer, BioRxiv (n.d.).","ama":"Habig M, Grasse AV, Müller J, Stukenbrock EH, Leitner H, Cremer S. Frequent horizontal chromosome transfer between asexual fungal insect pathogens. <i>bioRxiv</i>. doi:<a href=\"https://doi.org/10.1101/2023.09.18.558174\">10.1101/2023.09.18.558174</a>"},"date_published":"2023-09-19T00:00:00Z","acknowledgement":"We thank Bernhardt Steinwender, Jorgen Eilenberg and Nicolai V. Meyling for the fungal strains. We further thank Chengshu Wang for providing the short sequencing reads for M. guizhouense ARESF977 he used for his published genome assembly, and Kristian Ullrich for help in the bioinformatics analysis for methylation pattern in Nanopore reads, and the Vienna BioCenter and the Max Planck Society for the use of their sequencing centers. We thank Barbara Milutinović and Hinrich Schulenburg for discussion, and Tal Dagan and Jens Rolff for comments on a previous version of the manuscript. Fig1 A was created with BioRender.com. This study received funding by the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (No. 771402; EPIDEMICSonCHIP) to S.C. and by the German Research Foundation (DFG grant HA9263/1-1) to M.H.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"project":[{"_id":"2649B4DE-B435-11E9-9278-68D0E5697425","name":"Epidemics in ant societies on a chip","grant_number":"771402","call_identifier":"H2020"}],"publication":"bioRxiv","status":"public","language":[{"iso":"eng"}],"date_updated":"2023-11-07T11:20:54Z","_id":"14478","type":"preprint","date_created":"2023-10-31T13:30:00Z","doi":"10.1101/2023.09.18.558174","author":[{"first_name":"Michael","last_name":"Habig","full_name":"Habig, Michael"},{"first_name":"Anna V","full_name":"Grasse, Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","last_name":"Grasse"},{"first_name":"Judith","full_name":"Müller, Judith","last_name":"Müller"},{"first_name":"Eva H.","last_name":"Stukenbrock","full_name":"Stukenbrock, Eva H."},{"first_name":"Hanna","last_name":"Leitner","id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","full_name":"Leitner, Hanna"},{"first_name":"Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","last_name":"Cremer"}],"day":"19","article_processing_charge":"No","oa_version":"Preprint","title":"Frequent horizontal chromosome transfer between asexual fungal insect pathogens","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2023.09.18.558174"}],"publication_status":"submitted","abstract":[{"text":"Entire chromosomes are typically only transmitted vertically from one generation to the next. The horizontal transfer of such chromosomes has long been considered improbable, yet gained recent support in several pathogenic fungi where it may affect the fitness or host specificity. To date, it is unknown how these transfers occur, how common they are and whether they can occur between different species. In this study, we show multiple independent instances of horizontal transfers of the same accessory chromosome between two distinct strains of the asexual entomopathogenic fungus<jats:italic>Metarhizium robertsii</jats:italic>during experimental co-infection of its insect host, the Argentine ant. Notably, only the one chromosome – but no other – was transferred from the donor to the recipient strain. The recipient strain, now harboring the accessory chromosome, exhibited a competitive advantage under certain host conditions. By phylogenetic analysis we further demonstrate that the same accessory chromosome was horizontally transferred in a natural environment between<jats:italic>M. robertsii</jats:italic>and another congeneric insect pathogen,<jats:italic>M. guizhouense</jats:italic>. Hence horizontal chromosome transfer is not limited to the observed frequent events within species during experimental infections but also occurs naturally across species. The transferred accessory chromosome contains genes that might be involved in its preferential horizontal transfer, encoding putative histones and histone-modifying enzymes, but also putative virulence factors that may support its establishment. Our study reveals that both intra- and interspecies horizontal transfer of entire chromosomes is more frequent than previously assumed, likely representing a not uncommon mechanism for gene exchange.</jats:p><jats:sec><jats:title>Significance Statement</jats:title><jats:p>The enormous success of bacterial pathogens has been attributed to their ability to exchange genetic material between one another. Similarly, in eukaryotes, horizontal transfer of genetic material allowed the spread of virulence factors across species. The horizontal transfer of whole chromosomes could be an important pathway for such exchange of genetic material, but little is known about the origin of transferable chromosomes and how frequently they are exchanged. Here, we show that the transfer of accessory chromosomes - chromosomes that are non-essential but may provide fitness benefits - is common during fungal co-infections and is even possible between distant pathogenic species, highlighting the importance of horizontal gene transfer via chromosome transfer also for the evolution and function of eukaryotic pathogens.","lang":"eng"}]},{"ddc":["570"],"quality_controlled":"1","article_processing_charge":"Yes","doi":"10.1038/s41467-023-38947-y","publisher":"Springer Nature","_id":"13127","date_updated":"2023-08-07T13:09:09Z","type":"journal_article","publication":"Nature Communications","status":"public","project":[{"call_identifier":"H2020","grant_number":"771402","name":"Epidemics in ant societies on a chip","_id":"2649B4DE-B435-11E9-9278-68D0E5697425"},{"grant_number":"RGP0065/2012","name":"Information processing and computation in fish groups","_id":"255008E4-B435-11E9-9278-68D0E5697425"}],"ec_funded":1,"pmid":1,"acknowledgement":"We thank Mike Bidochka for the fungal strains, the ISTA Social Immunity Team for ant collection, Hanna Leitner for experimental and molecular support, Jennifer Robb and Lukas Lindorfer for microscopy, and the LabSupport Facility at ISTA for general laboratory support. We further thank Victor Mireles, Iain Couzin, Fabian Theis and the Social Immunity Team for continued feedback throughout, and Michael Sixt, Yuko Ulrich, Koos Boomsma, Erika Dawson, Megan Kutzer and Hinrich Schulenburg for comments on the manuscript. This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (Grant No. 771402; EPIDEMICSonCHIP) to SC, from the Scientific Grant Agency of the Slovak Republic (Grant No. 1/0521/20) to KB, and the Human Frontier Science Program (Grant No. RGP0065/2012) to GT.","date_published":"2023-06-03T00:00:00Z","isi":1,"year":"2023","related_material":{"record":[{"status":"public","relation":"research_data","id":"12945"}]},"external_id":{"isi":["001002562700005"],"pmid":["37270641"]},"has_accepted_license":"1","acknowledged_ssus":[{"_id":"LifeSc"}],"abstract":[{"text":"Cooperative disease defense emerges as group-level collective behavior, yet how group members make the underlying individual decisions is poorly understood. Using garden ants and fungal pathogens as an experimental model, we derive the rules governing individual ant grooming choices and show how they produce colony-level hygiene. Time-resolved behavioral analysis, pathogen quantification, and probabilistic modeling reveal that ants increase grooming and preferentially target highly-infectious individuals when perceiving high pathogen load, but transiently suppress grooming after having been groomed by nestmates. Ants thus react to both, the infectivity of others and the social feedback they receive on their own contagiousness. While inferred solely from momentary ant decisions, these behavioral rules quantitatively predict hour-long experimental dynamics, and synergistically combine into efficient colony-wide pathogen removal. Our analyses show that noisy individual decisions based on only local, incomplete, yet dynamically-updated information on pathogen threat and social feedback can lead to potent collective disease defense.","lang":"eng"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"intvolume":"        14","file_date_updated":"2023-06-13T08:05:46Z","publication_identifier":{"eissn":["2041-1723"]},"publication_status":"published","scopus_import":"1","day":"03","author":[{"last_name":"Casillas Perez","full_name":"Casillas Perez, Barbara E","id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara E"},{"id":"2BA24EA0-F248-11E8-B48F-1D18A9856A87","full_name":"Bod'Ová, Katarína","last_name":"Bod'Ová","orcid":"0000-0002-7214-0171","first_name":"Katarína"},{"first_name":"Anna V","last_name":"Grasse","id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V"},{"last_name":"Tkačik","full_name":"Tkačik, Gašper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6699-1455","first_name":"Gašper"},{"last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","first_name":"Sylvia","orcid":"0000-0002-2193-3868"}],"oa_version":"Published Version","title":"Dynamic pathogen detection and social feedback shape collective hygiene in ants","volume":14,"date_created":"2023-06-11T22:00:40Z","article_type":"original","oa":1,"language":[{"iso":"eng"}],"citation":{"ieee":"B. E. Casillas Perez, K. Bodova, A. V. Grasse, G. Tkačik, and S. Cremer, “Dynamic pathogen detection and social feedback shape collective hygiene in ants,” <i>Nature Communications</i>, vol. 14. Springer Nature, 2023.","short":"B.E. Casillas Perez, K. Bodova, A.V. Grasse, G. Tkačik, S. Cremer, Nature Communications 14 (2023).","ama":"Casillas Perez BE, Bodova K, Grasse AV, Tkačik G, Cremer S. Dynamic pathogen detection and social feedback shape collective hygiene in ants. <i>Nature Communications</i>. 2023;14. doi:<a href=\"https://doi.org/10.1038/s41467-023-38947-y\">10.1038/s41467-023-38947-y</a>","apa":"Casillas Perez, B. E., Bodova, K., Grasse, A. V., Tkačik, G., &#38; Cremer, S. (2023). Dynamic pathogen detection and social feedback shape collective hygiene in ants. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-023-38947-y\">https://doi.org/10.1038/s41467-023-38947-y</a>","mla":"Casillas Perez, Barbara E., et al. “Dynamic Pathogen Detection and Social Feedback Shape Collective Hygiene in Ants.” <i>Nature Communications</i>, vol. 14, 3232, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1038/s41467-023-38947-y\">10.1038/s41467-023-38947-y</a>.","chicago":"Casillas Perez, Barbara E, Katarina Bodova, Anna V Grasse, Gašper Tkačik, and Sylvia Cremer. “Dynamic Pathogen Detection and Social Feedback Shape Collective Hygiene in Ants.” <i>Nature Communications</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41467-023-38947-y\">https://doi.org/10.1038/s41467-023-38947-y</a>.","ista":"Casillas Perez BE, Bodova K, Grasse AV, Tkačik G, Cremer S. 2023. Dynamic pathogen detection and social feedback shape collective hygiene in ants. Nature Communications. 14, 3232."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"06","department":[{"_id":"SyCr"},{"_id":"GaTk"}],"file":[{"access_level":"open_access","content_type":"application/pdf","success":1,"file_name":"2023_NatureComm_CasillasPerez.pdf","checksum":"4af0393e3ed47b3fc46e68b81c3c1007","relation":"main_file","date_updated":"2023-06-13T08:05:46Z","creator":"dernst","date_created":"2023-06-13T08:05:46Z","file_size":2358167,"file_id":"13132"}],"article_number":"3232"},{"ddc":["570"],"quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","doi":"10.3389/fmicb.2023.1119002","publisher":"Frontiers","_id":"12469","date_updated":"2023-08-01T12:39:58Z","type":"journal_article","publication":"Frontiers in Microbiology","status":"public","project":[{"grant_number":"M02076","name":"Viral pathogens and social immunity in ants","call_identifier":"FWF","_id":"25DF61D8-B435-11E9-9278-68D0E5697425"}],"pmid":1,"acknowledgement":"We thank D.J. Obbard for sharing the details of the dual RNA-seq/sRNA-seq approach, S.\r\nMetzler and R. Ferrigato for the photographs (Figure 1), M. Konrad, B. Casillas-Perez, C.D.\r\nPull and X. Espadaler for help with ant collection, and the Social Immunity Team at IST\r\nAustria, in particular J. Robb, A. Franschitz, E. Naderlinger, E. Dawson and B. Casillas-Perez\r\nfor support and comments on the manuscript. The study was funded by the Austrian Science\r\nFund (FWF; M02076-B25 to MAF) and the Academy of Finland (343022 to LV). ","date_published":"2023-03-16T00:00:00Z","isi":1,"year":"2023","external_id":{"pmid":["PPR559293 "],"isi":["000961542100001"]},"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"intvolume":"        14","abstract":[{"text":"Hosts can carry many viruses in their bodies, but not all of them cause disease. We studied ants as a social host to determine both their overall viral repertoire and the subset of actively infecting viruses across natural populations of three subfamilies: the Argentine ant (Linepithema humile, Dolichoderinae), the invasive garden ant (Lasius neglectus, Formicinae) and the red ant (Myrmica rubra, Myrmicinae). We used a dual sequencing strategy to reconstruct complete virus genomes by RNA-seq and to simultaneously determine the small interfering RNAs (siRNAs) by small RNA sequencing (sRNA-seq), which constitute the host antiviral RNAi immune response. This approach led to the discovery of 41 novel viruses in ants and revealed a host ant-specific RNAi response (21 vs. 22 nt siRNAs) in the different ant species. The efficiency of the RNAi response (sRNA/RNA read count ratio) depended on the virus and the respective ant species, but not its population. Overall, we found the highest virus abundance and diversity per population in Li. humile, followed by La. neglectus and M. rubra. Argentine ants also shared a high proportion of viruses between populations, whilst overlap was nearly absent in M. rubra. Only one of the 59 viruses was found to infect two of the ant species as hosts, revealing high host-specificity in active infections. In contrast, six viruses actively infected one ant species, but were found as contaminants only in the others. Disentangling spillover of disease-causing infection from non-infecting contamination across species is providing relevant information for disease ecology and ecosystem management.","lang":"eng"}],"file_date_updated":"2023-04-17T07:49:09Z","publication_identifier":{"eissn":["1664-302X"]},"publication_status":"published","day":"16","scopus_import":"1","author":[{"last_name":"Viljakainen","full_name":"Viljakainen, Lumi","first_name":"Lumi"},{"last_name":"Fürst","id":"393B1196-F248-11E8-B48F-1D18A9856A87","full_name":"Fürst, Matthias","orcid":"0000-0002-3712-925X","first_name":"Matthias"},{"first_name":"Anna V","last_name":"Grasse","id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V"},{"first_name":"Jaana","last_name":"Jurvansuu","full_name":"Jurvansuu, Jaana"},{"id":"403169A4-080F-11EA-9993-BF3F3DDC885E","full_name":"Oh, Jinook","last_name":"Oh","first_name":"Jinook","orcid":"0000-0001-7425-2372"},{"last_name":"Tolonen","full_name":"Tolonen, Lassi","first_name":"Lassi"},{"first_name":"Thomas","full_name":"Eder, Thomas","last_name":"Eder"},{"last_name":"Rattei","full_name":"Rattei, Thomas","first_name":"Thomas"},{"full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","orcid":"0000-0002-2193-3868","first_name":"Sylvia"}],"title":"Antiviral immune response reveals host-specific virus infections in natural ant populations","oa_version":"Published Version","volume":14,"date_created":"2023-01-31T08:13:40Z","article_type":"original","oa":1,"language":[{"iso":"eng"}],"citation":{"mla":"Viljakainen, Lumi, et al. “Antiviral Immune Response Reveals Host-Specific Virus Infections in Natural Ant Populations.” <i>Frontiers in Microbiology</i>, vol. 14, 1119002, Frontiers, 2023, doi:<a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">10.3389/fmicb.2023.1119002</a>.","apa":"Viljakainen, L., Fürst, M., Grasse, A. V., Jurvansuu, J., Oh, J., Tolonen, L., … Cremer, S. (2023). Antiviral immune response reveals host-specific virus infections in natural ant populations. <i>Frontiers in Microbiology</i>. Frontiers. <a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">https://doi.org/10.3389/fmicb.2023.1119002</a>","chicago":"Viljakainen, Lumi, Matthias Fürst, Anna V Grasse, Jaana Jurvansuu, Jinook Oh, Lassi Tolonen, Thomas Eder, Thomas Rattei, and Sylvia Cremer. “Antiviral Immune Response Reveals Host-Specific Virus Infections in Natural Ant Populations.” <i>Frontiers in Microbiology</i>. Frontiers, 2023. <a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">https://doi.org/10.3389/fmicb.2023.1119002</a>.","ista":"Viljakainen L, Fürst M, Grasse AV, Jurvansuu J, Oh J, Tolonen L, Eder T, Rattei T, Cremer S. 2023. Antiviral immune response reveals host-specific virus infections in natural ant populations. Frontiers in Microbiology. 14, 1119002.","short":"L. Viljakainen, M. Fürst, A.V. Grasse, J. Jurvansuu, J. Oh, L. Tolonen, T. Eder, T. Rattei, S. Cremer, Frontiers in Microbiology 14 (2023).","ieee":"L. Viljakainen <i>et al.</i>, “Antiviral immune response reveals host-specific virus infections in natural ant populations,” <i>Frontiers in Microbiology</i>, vol. 14. Frontiers, 2023.","ama":"Viljakainen L, Fürst M, Grasse AV, et al. Antiviral immune response reveals host-specific virus infections in natural ant populations. <i>Frontiers in Microbiology</i>. 2023;14. doi:<a href=\"https://doi.org/10.3389/fmicb.2023.1119002\">10.3389/fmicb.2023.1119002</a>"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","month":"03","department":[{"_id":"SyCr"}],"file":[{"date_updated":"2023-04-17T07:49:09Z","creator":"dernst","file_size":4866332,"date_created":"2023-04-17T07:49:09Z","file_id":"12843","content_type":"application/pdf","access_level":"open_access","file_name":"2023_FrontMicrobiology_Viljakainen.pdf","success":1,"checksum":"cd52292963acce1111634d9fac08c699","relation":"main_file"}],"article_number":"1119002"},{"has_accepted_license":"1","abstract":[{"text":"Treating sick group members is a hallmark of collective disease defence in vertebrates and invertebrates alike. Despite substantial effects on pathogen fitness and epidemiology, it is still largely unknown how pathogens react to the selection pressure imposed by care intervention. Using social insects and pathogenic fungi, we here performed a serial passage experiment in the presence or absence of colony members, which provide social immunity by grooming off infectious spores from exposed individuals. We found specific effects on pathogen diversity, virulence and transmission. Under selection of social immunity, pathogens invested into higher spore production, but spores were less virulent. Notably, they also elicited a lower grooming response in colony members, compared with spores from the individual host selection lines. Chemical spore analysis suggested that the spores from social selection lines escaped the caregivers’ detection by containing lower levels of ergosterol, a key fungal membrane component. Experimental application of chemically pure ergosterol indeed induced sanitary grooming, supporting its role as a microbe-associated cue triggering host social immunity against fungal pathogens. By reducing this detection cue, pathogens were able to evade the otherwise very effective collective disease defences of their social hosts.","lang":"eng"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"intvolume":"         7","acknowledged_ssus":[{"_id":"LifeSc"}],"publication_status":"published","publication_identifier":{"eissn":["2397-334X"]},"file_date_updated":"2023-08-16T11:54:59Z","author":[{"first_name":"Miriam","id":"42462816-F248-11E8-B48F-1D18A9856A87","full_name":"Stock, Miriam","last_name":"Stock"},{"id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","full_name":"Milutinovic, Barbara","last_name":"Milutinovic","orcid":"0000-0002-8214-4758","first_name":"Barbara"},{"last_name":"Hönigsberger","full_name":"Hönigsberger, Michaela","id":"953894f3-25bd-11ec-8556-f70a9d38ef60","first_name":"Michaela"},{"first_name":"Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V","last_name":"Grasse"},{"first_name":"Florian","full_name":"Wiesenhofer, Florian","id":"39523C54-F248-11E8-B48F-1D18A9856A87","last_name":"Wiesenhofer"},{"first_name":"Niklas","last_name":"Kampleitner","full_name":"Kampleitner, Niklas","id":"2AC57FAC-F248-11E8-B48F-1D18A9856A87"},{"id":"44BF24D0-F248-11E8-B48F-1D18A9856A87","full_name":"Narasimhan, Madhumitha","last_name":"Narasimhan","orcid":"0000-0002-8600-0671","first_name":"Madhumitha"},{"first_name":"Thomas","last_name":"Schmitt","full_name":"Schmitt, Thomas"},{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","last_name":"Cremer","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"day":"01","scopus_import":"1","oa_version":"Published Version","title":"Pathogen evasion of social immunity","volume":7,"article_type":"original","date_created":"2023-02-12T23:00:59Z","oa":1,"language":[{"iso":"eng"}],"citation":{"ieee":"M. Stock <i>et al.</i>, “Pathogen evasion of social immunity,” <i>Nature Ecology and Evolution</i>, vol. 7. Springer Nature, pp. 450–460, 2023.","short":"M. Stock, B. Milutinovic, M. Hönigsberger, A.V. Grasse, F. Wiesenhofer, N. Kampleitner, M. Narasimhan, T. Schmitt, S. Cremer, Nature Ecology and Evolution 7 (2023) 450–460.","ama":"Stock M, Milutinovic B, Hönigsberger M, et al. Pathogen evasion of social immunity. <i>Nature Ecology and Evolution</i>. 2023;7:450-460. doi:<a href=\"https://doi.org/10.1038/s41559-023-01981-6\">10.1038/s41559-023-01981-6</a>","apa":"Stock, M., Milutinovic, B., Hönigsberger, M., Grasse, A. V., Wiesenhofer, F., Kampleitner, N., … Cremer, S. (2023). Pathogen evasion of social immunity. <i>Nature Ecology and Evolution</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41559-023-01981-6\">https://doi.org/10.1038/s41559-023-01981-6</a>","mla":"Stock, Miriam, et al. “Pathogen Evasion of Social Immunity.” <i>Nature Ecology and Evolution</i>, vol. 7, Springer Nature, 2023, pp. 450–60, doi:<a href=\"https://doi.org/10.1038/s41559-023-01981-6\">10.1038/s41559-023-01981-6</a>.","chicago":"Stock, Miriam, Barbara Milutinovic, Michaela Hönigsberger, Anna V Grasse, Florian Wiesenhofer, Niklas Kampleitner, Madhumitha Narasimhan, Thomas Schmitt, and Sylvia Cremer. “Pathogen Evasion of Social Immunity.” <i>Nature Ecology and Evolution</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41559-023-01981-6\">https://doi.org/10.1038/s41559-023-01981-6</a>.","ista":"Stock M, Milutinovic B, Hönigsberger M, Grasse AV, Wiesenhofer F, Kampleitner N, Narasimhan M, Schmitt T, Cremer S. 2023. Pathogen evasion of social immunity. Nature Ecology and Evolution. 7, 450–460."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"03","department":[{"_id":"SyCr"},{"_id":"LifeSc"},{"_id":"JiFr"}],"file":[{"creator":"dernst","date_updated":"2023-08-16T11:54:59Z","file_size":1600499,"date_created":"2023-08-16T11:54:59Z","file_id":"14069","access_level":"open_access","content_type":"application/pdf","success":1,"file_name":"2023_NatureEcoEvo_Stock.pdf","checksum":"8244f4650a0e7aeea488d1bcd4a31702","relation":"main_file"}],"page":"450-460","ddc":["570"],"quality_controlled":"1","doi":"10.1038/s41559-023-01981-6","article_processing_charge":"No","publisher":"Springer Nature","date_updated":"2023-08-16T11:55:48Z","_id":"12543","type":"journal_article","project":[{"_id":"2649B4DE-B435-11E9-9278-68D0E5697425","name":"Epidemics in ant societies on a chip","grant_number":"771402","call_identifier":"H2020"},{"_id":"25DAF0B2-B435-11E9-9278-68D0E5697425","name":"Host-Parasite Coevolution","grant_number":"CR-118/3-1"}],"status":"public","publication":"Nature Ecology and Evolution","pmid":1,"ec_funded":1,"date_published":"2023-03-01T00:00:00Z","acknowledgement":"We thank B. M. Steinwender, N. V. Meyling and J. Eilenberg for the fungal strains; J. Anaya-Rojas for statistical advice; the Social Immunity team at ISTA for ant collection and experimental help, in particular H. Leitner, and the ISTA Lab Support Facility for general laboratory support; D. Ebert, H. Schulenburg and J. Heinze for continued project discussion; and M. Sixt, R. Roemhild and the Social Immunity team for comments on the manuscript. The study was funded by the German Research Foundation (CR118/3-1) within the Framework of the Priority Program SPP 1399, and the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (No. 771402; EPIDEMICSonCHIP), both to S.C.","isi":1,"year":"2023","external_id":{"isi":["000924572800001"],"pmid":["36732670"]},"related_material":{"link":[{"url":"https://ista.ac.at/en/news/how-sneaky-germs-hide-from-ants/","description":"News on ISTA website","relation":"press_release"}]}},{"file":[{"checksum":"c1565d655ca05601acfd84e0d12b8563","relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_name":"Metzler_ReadMe.pdf","success":1,"file_id":"12694","creator":"scremer","date_updated":"2023-02-28T06:34:08Z","file_size":77070,"date_created":"2023-02-28T06:34:08Z"},{"relation":"main_file","checksum":"75c4c4948563d6261cb7548f80d909f1","file_name":"Metzler_RepositoryData.xlsx","success":1,"content_type":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","access_level":"open_access","file_id":"12695","date_created":"2023-02-28T06:34:12Z","file_size":88001,"creator":"scremer","date_updated":"2023-02-28T06:34:12Z"}],"department":[{"_id":"SyCr"}],"month":"02","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"12696"}]},"year":"2023","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2023-02-28T00:00:00Z","citation":{"chicago":"Cremer, Sylvia. “Source Data for Metzler et Al, 2023: Trade-Offs between Immunity and Competitive Ability in Fighting Ant Males .” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/AT:ISTA:12693\">https://doi.org/10.15479/AT:ISTA:12693</a>.","ista":"Cremer S. 2023. Source data for Metzler et al, 2023: Trade-offs between immunity and competitive ability in fighting ant males , Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:12693\">10.15479/AT:ISTA:12693</a>.","mla":"Cremer, Sylvia. <i>Source Data for Metzler et Al, 2023: Trade-Offs between Immunity and Competitive Ability in Fighting Ant Males </i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12693\">10.15479/AT:ISTA:12693</a>.","apa":"Cremer, S. (2023). Source data for Metzler et al, 2023: Trade-offs between immunity and competitive ability in fighting ant males . Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:12693\">https://doi.org/10.15479/AT:ISTA:12693</a>","ama":"Cremer S. Source data for Metzler et al, 2023: Trade-offs between immunity and competitive ability in fighting ant males . 2023. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12693\">10.15479/AT:ISTA:12693</a>","short":"S. Cremer, (2023).","ieee":"S. Cremer, “Source data for Metzler et al, 2023: Trade-offs between immunity and competitive ability in fighting ant males .” Institute of Science and Technology Austria, 2023."},"status":"public","oa":1,"date_created":"2023-02-28T06:38:37Z","type":"research_data","_id":"12693","date_updated":"2023-12-13T11:13:13Z","oa_version":"Published Version","title":"Source data for Metzler et al, 2023: Trade-offs between immunity and competitive ability in fighting ant males ","publisher":"Institute of Science and Technology Austria","article_processing_charge":"No","day":"28","contributor":[{"first_name":"Sina","contributor_type":"data_collector","last_name":"Metzler","id":"48204546-F248-11E8-B48F-1D18A9856A87"},{"id":"21516227-15aa-11ec-9fb2-c6e8ffc155d3","last_name":"Kirchner","first_name":"Jessica","contributor_type":"data_collector"},{"last_name":"Grasse","id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V","contributor_type":"data_collector"}],"author":[{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer"}],"doi":"10.15479/AT:ISTA:12693","file_date_updated":"2023-02-28T06:34:12Z","ddc":["570"],"abstract":[{"text":"See Readme File for further information.","lang":"eng"}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"has_accepted_license":"1"},{"ddc":["570"],"quality_controlled":"1","article_processing_charge":"Yes","doi":"10.1186/s12862-023-02137-7","publisher":"Springer Nature","_id":"12696","date_updated":"2023-12-13T11:13:14Z","type":"journal_article","status":"public","publication":"BMC Ecology and Evolution","project":[{"_id":"2649B4DE-B435-11E9-9278-68D0E5697425","grant_number":"771402","name":"Epidemics in ant societies on a chip","call_identifier":"H2020"}],"ec_funded":1,"pmid":1,"acknowledgement":"We are thankful to Mike Bidochka for the fungal strain, Lukas Schrader for sharing the C. obscurior genome data for primer development, the Lab Support Facility of ISTA for general laboratory support and help with the permit approval procedures, and the Finca El Quinto for letting us collect ants on their property. We thank the Social Immunity Team at ISTA for help with ant collection and experimental help, in particular Elina Hanhimäki and Marta Gorecka for behavioural observation, and Elisabeth Naderlinger for spore load PCRs. We further thank the Social Immunity Team and Jürgen Heinze for continued discussion and comments on the manuscript.\r\nOpen access funding provided by Institute of Science and Technology Austria (ISTA). This project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 771402 to SC). ","date_published":"2023-08-07T00:00:00Z","year":"2023","isi":1,"related_material":{"record":[{"id":"12693","relation":"research_data","status":"public"}]},"external_id":{"isi":["001042643600002"],"pmid":["37550612"]},"has_accepted_license":"1","acknowledged_ssus":[{"_id":"LifeSc"}],"intvolume":"        23","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"abstract":[{"lang":"eng","text":"Background: Fighting disease while fighting rivals exposes males to constraints and tradeoffs during male-male competition. We here tested how both the stage and intensity of infection with the fungal pathogen Metarhizium robertsii interfered with fighting success in Cardiocondyla obscurior ant males. Males of this species have evolved long lifespans during which they can gain many matings with the young queens of the colony, if successful in male-male competition. Since male fights occur inside the colony, the outcome of male-male competition can further be biased by interference of the colony’s worker force.\r\nResults: We found that severe, but not yet mild, infection strongly impaired male fighting success. In late-stage infection, this could be attributed to worker aggression directed towards the infected rather than the healthy male and an already very high male morbidity even in the absence of fighting. Shortly after pathogen exposure, however, male mortality was particularly increased during combat. Since these males mounted a strong immune response, their reduced fighting success suggests a trade-off between immune investment and competitive ability already early in the infection. Even if the males themselves showed no difference in the number of attacks they raised against their healthy rivals across infection stages and levels, severely infected males were thus losing in male-male competition from an early stage of infection on.\r\nConclusions: Males of the ant C. obscurior have evolved high immune investment, triggering an effective immune response very fast after fungal exposure. This allows them to cope with mild pathogen exposures without cost to their success in male-male competition, and hence to gain multiple mating opportunities with the emerging virgin queens of the colony. Under severe infection, however, they are weak fighters and rarely survive a combat already at early infection when raising an immune response, as well as at progressed infection, when they are morbid and preferentially targeted by worker aggression. Workers thereby remove males that pose a future disease threat by biasing male-male competition. Our study thus revealed a novel social immunity mechanism how social insect workers protect the colony against disease risk."}],"file_date_updated":"2023-08-14T07:51:47Z","publication_identifier":{"issn":["2730-7182"]},"publication_status":"published","scopus_import":"1","day":"07","author":[{"full_name":"Metzler, Sina","id":"48204546-F248-11E8-B48F-1D18A9856A87","last_name":"Metzler","orcid":"0000-0002-9547-2494","first_name":"Sina"},{"full_name":"Kirchner, Jessica","id":"21516227-15aa-11ec-9fb2-c6e8ffc155d3","last_name":"Kirchner","first_name":"Jessica"},{"last_name":"Grasse","full_name":"Grasse, Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V"},{"last_name":"Cremer","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","orcid":"0000-0002-2193-3868"}],"title":"Trade-offs between immunity and competitive ability in fighting ant males","oa_version":"Published Version","volume":23,"date_created":"2023-02-28T07:38:17Z","article_type":"original","oa":1,"language":[{"iso":"eng"}],"citation":{"chicago":"Metzler, Sina, Jessica Kirchner, Anna V Grasse, and Sylvia Cremer. “Trade-Offs between Immunity and Competitive Ability in Fighting Ant Males.” <i>BMC Ecology and Evolution</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1186/s12862-023-02137-7\">https://doi.org/10.1186/s12862-023-02137-7</a>.","ista":"Metzler S, Kirchner J, Grasse AV, Cremer S. 2023. Trade-offs between immunity and competitive ability in fighting ant males. BMC Ecology and Evolution. 23, 37.","mla":"Metzler, Sina, et al. “Trade-Offs between Immunity and Competitive Ability in Fighting Ant Males.” <i>BMC Ecology and Evolution</i>, vol. 23, 37, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1186/s12862-023-02137-7\">10.1186/s12862-023-02137-7</a>.","apa":"Metzler, S., Kirchner, J., Grasse, A. V., &#38; Cremer, S. (2023). Trade-offs between immunity and competitive ability in fighting ant males. <i>BMC Ecology and Evolution</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s12862-023-02137-7\">https://doi.org/10.1186/s12862-023-02137-7</a>","ama":"Metzler S, Kirchner J, Grasse AV, Cremer S. Trade-offs between immunity and competitive ability in fighting ant males. <i>BMC Ecology and Evolution</i>. 2023;23. doi:<a href=\"https://doi.org/10.1186/s12862-023-02137-7\">10.1186/s12862-023-02137-7</a>","short":"S. Metzler, J. Kirchner, A.V. Grasse, S. Cremer, BMC Ecology and Evolution 23 (2023).","ieee":"S. Metzler, J. Kirchner, A. V. Grasse, and S. Cremer, “Trade-offs between immunity and competitive ability in fighting ant males,” <i>BMC Ecology and Evolution</i>, vol. 23. Springer Nature, 2023."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"08","department":[{"_id":"SyCr"}],"file":[{"file_id":"14048","date_created":"2023-08-14T07:51:47Z","file_size":2004276,"creator":"dernst","date_updated":"2023-08-14T07:51:47Z","relation":"main_file","checksum":"95966dc7d242d2c85bdd4fe14233dbd8","success":1,"file_name":"2023_BMCEcology_Metzler.pdf","access_level":"open_access","content_type":"application/pdf"}],"article_number":"37"},{"volume":37,"date_created":"2023-03-26T22:01:09Z","article_type":"review","day":"01","scopus_import":"1","author":[{"first_name":"Sebastian","full_name":"Stockmaier, Sebastian","last_name":"Stockmaier"},{"first_name":"Yuko","last_name":"Ulrich","full_name":"Ulrich, Yuko"},{"last_name":"Albery","full_name":"Albery, Gregory F.","first_name":"Gregory F."},{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia"},{"last_name":"Lopes","full_name":"Lopes, Patricia C.","first_name":"Patricia C."}],"oa_version":"None","title":"Behavioural defences against parasites across host social structures","publication_status":"published","publication_identifier":{"eissn":["1365-2435"],"issn":["0269-8463"]},"intvolume":"        37","abstract":[{"text":"Animals exhibit a variety of behavioural defences against socially transmitted parasites. These defences evolved to increase host fitness by avoiding, resisting or tolerating infection.\r\nBecause they can occur in both infected individuals and their uninfected social partners, these defences often have important consequences for the social group.\r\nHere, we discuss the evolution and ecology of anti-parasite behavioural defences across a taxonomically wide social spectrum, considering colonial groups, stable groups, transitional groups and solitary animals.\r\nWe discuss avoidance, resistance and tolerance behaviours across these social group structures, identifying how social complexity, group composition and interdependent social relationships may contribute to the expression and evolution of behavioural strategies.\r\nFinally, we outline avenues for further investigation such as approaches to quantify group-level responses, and the connection of the physiological and behavioural response to parasites in different social contexts.","lang":"eng"}],"department":[{"_id":"SyCr"}],"month":"04","citation":{"mla":"Stockmaier, Sebastian, et al. “Behavioural Defences against Parasites across Host Social Structures.” <i>Functional Ecology</i>, vol. 37, no. 4, British Ecological Society, 2023, pp. 809–20, doi:<a href=\"https://doi.org/10.1111/1365-2435.14310\">10.1111/1365-2435.14310</a>.","apa":"Stockmaier, S., Ulrich, Y., Albery, G. F., Cremer, S., &#38; Lopes, P. C. (2023). Behavioural defences against parasites across host social structures. <i>Functional Ecology</i>. British Ecological Society. <a href=\"https://doi.org/10.1111/1365-2435.14310\">https://doi.org/10.1111/1365-2435.14310</a>","ista":"Stockmaier S, Ulrich Y, Albery GF, Cremer S, Lopes PC. 2023. Behavioural defences against parasites across host social structures. Functional Ecology. 37(4), 809–820.","chicago":"Stockmaier, Sebastian, Yuko Ulrich, Gregory F. Albery, Sylvia Cremer, and Patricia C. Lopes. “Behavioural Defences against Parasites across Host Social Structures.” <i>Functional Ecology</i>. British Ecological Society, 2023. <a href=\"https://doi.org/10.1111/1365-2435.14310\">https://doi.org/10.1111/1365-2435.14310</a>.","short":"S. Stockmaier, Y. Ulrich, G.F. Albery, S. Cremer, P.C. Lopes, Functional Ecology 37 (2023) 809–820.","ieee":"S. Stockmaier, Y. Ulrich, G. F. Albery, S. Cremer, and P. C. Lopes, “Behavioural defences against parasites across host social structures,” <i>Functional Ecology</i>, vol. 37, no. 4. British Ecological Society, pp. 809–820, 2023.","ama":"Stockmaier S, Ulrich Y, Albery GF, Cremer S, Lopes PC. Behavioural defences against parasites across host social structures. <i>Functional Ecology</i>. 2023;37(4):809-820. doi:<a href=\"https://doi.org/10.1111/1365-2435.14310\">10.1111/1365-2435.14310</a>"},"issue":"4","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"_id":"12765","date_updated":"2023-10-04T11:50:15Z","type":"journal_article","article_processing_charge":"No","doi":"10.1111/1365-2435.14310","publisher":"British Ecological Society","quality_controlled":"1","page":"809-820","isi":1,"year":"2023","external_id":{"isi":["000948940500001"]},"date_published":"2023-04-01T00:00:00Z","status":"public","publication":"Functional Ecology"},{"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant No. 771402; EPIDEMICSonCHIP) to SC, from the Scientific Grant Agency of the Slovak Republic (Grant No. 1/0521/20) to KB, and the Human Frontier Science Program (Grant No. RGP0065/2012) to GT.","date_published":"2023-05-12T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Cremer S. 2023. Data from: ‘Dynamic pathogen detection and social feedback shape collective hygiene in ants’ , Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:12945\">10.15479/AT:ISTA:12945</a>.","chicago":"Cremer, Sylvia. “Data from: ‘Dynamic Pathogen Detection and Social Feedback Shape Collective Hygiene in Ants’ .” Institute of Science and Technology Austria, 2023. <a href=\"https://doi.org/10.15479/AT:ISTA:12945\">https://doi.org/10.15479/AT:ISTA:12945</a>.","apa":"Cremer, S. (2023). Data from: “Dynamic pathogen detection and social feedback shape collective hygiene in ants” . Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:12945\">https://doi.org/10.15479/AT:ISTA:12945</a>","mla":"Cremer, Sylvia. <i>Data from: “Dynamic Pathogen Detection and Social Feedback Shape Collective Hygiene in Ants” </i>. Institute of Science and Technology Austria, 2023, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12945\">10.15479/AT:ISTA:12945</a>.","ama":"Cremer S. Data from: “Dynamic pathogen detection and social feedback shape collective hygiene in ants” . 2023. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:12945\">10.15479/AT:ISTA:12945</a>","ieee":"S. Cremer, “Data from: ‘Dynamic pathogen detection and social feedback shape collective hygiene in ants’ .” Institute of Science and Technology Austria, 2023.","short":"S. Cremer, (2023)."},"status":"public","oa":1,"keyword":["collective behavior","host-pathogen interactions","social immunity","epidemiology","social insects","probabilistic modeling"],"file":[{"file_id":"12947","file_size":3414674,"date_created":"2023-05-12T08:04:04Z","date_updated":"2023-05-12T08:04:04Z","creator":"scremer","relation":"main_file","checksum":"3eadf17fd59ad8c98bf10bf63061863c","file_name":"Experimental_data.zip","success":1,"content_type":"application/zip","access_level":"open_access"},{"relation":"main_file","checksum":"1b5e8e01a0989154a76b44e6d8d68f89","success":1,"file_name":"README_Experimental_Data.md","access_level":"open_access","content_type":"application/octet-stream","file_id":"12948","file_size":2113,"date_created":"2023-05-12T08:04:08Z","creator":"scremer","date_updated":"2023-05-12T08:04:08Z"}],"department":[{"_id":"SyCr"}],"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"13127"}]},"month":"05","year":"2023","file_date_updated":"2023-05-12T08:04:08Z","abstract":[{"lang":"eng","text":"basic data for use in code for experimental data analysis for manuscript under revision: \r\nDynamic pathogen detection and social feedback shape collective hygiene in ants\r\nCasillas-Pérez B, Boďová K, Grasse AV, Tkačik G, Cremer S"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"acknowledged_ssus":[{"_id":"LifeSc"}],"ddc":["570"],"has_accepted_license":"1","type":"research_data","date_created":"2023-05-11T21:35:17Z","date_updated":"2023-08-07T13:09:09Z","_id":"12945","publisher":"Institute of Science and Technology Austria","title":"Data from: \"Dynamic pathogen detection and social feedback shape collective hygiene in ants\" ","oa_version":"None","author":[{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","last_name":"Cremer","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"doi":"10.15479/AT:ISTA:12945","article_processing_charge":"No","contributor":[{"contributor_type":"data_collector","first_name":"Barbara E","id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","last_name":"Casillas Perez"},{"contributor_type":"data_collector","first_name":"Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","last_name":"Grasse"},{"last_name":"Bodova","first_name":"Katarina","contributor_type":"researcher"},{"last_name":"Tkačik","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","contributor_type":"supervisor","orcid":"0000-0002-6699-1455","first_name":"Gašper"}],"day":"12"},{"author":[{"first_name":"Barbara E","id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","full_name":"Casillas Perez, Barbara E","last_name":"Casillas Perez"},{"id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","full_name":"Pull, Christopher","last_name":"Pull","orcid":"0000-0003-1122-3982","first_name":"Christopher"},{"first_name":"Filip","full_name":"Naiser, Filip","last_name":"Naiser"},{"last_name":"Naderlinger","id":"31757262-F248-11E8-B48F-1D18A9856A87","full_name":"Naderlinger, Elisabeth","first_name":"Elisabeth"},{"last_name":"Matas","full_name":"Matas, Jiri","first_name":"Jiri"},{"first_name":"Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","last_name":"Cremer"}],"scopus_import":"1","day":"01","title":"Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies","oa_version":"Published Version","volume":25,"article_type":"original","date_created":"2021-11-14T23:01:25Z","has_accepted_license":"1","abstract":[{"lang":"eng","text":"Infections early in life can have enduring effects on an organism's development and immunity. In this study, we show that this equally applies to developing ‘superorganisms’––incipient social insect colonies. When we exposed newly mated Lasius niger ant queens to a low pathogen dose, their colonies grew more slowly than controls before winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation survival improved when the ratio of pupae to workers was small. Queens that reared fewer pupae before worker emergence exhibited lower pathogen levels, indicating that high brood rearing efforts interfere with the ability of the queen's immune system to suppress pathogen proliferation. Early-life queen pathogen exposure also improved the immunocompetence of her worker offspring, as demonstrated by challenging the workers to the same pathogen a year later. Transgenerational transfer of the queen's pathogen experience to her workforce can hence durably reduce the disease susceptibility of the whole superorganism."}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"intvolume":"        25","acknowledged_ssus":[{"_id":"ScienComp"}],"publication_identifier":{"issn":["1461-023X"],"eissn":["1461-0248"]},"publication_status":"published","file_date_updated":"2022-02-03T13:37:11Z","month":"01","department":[{"_id":"SyCr"}],"file":[{"access_level":"open_access","content_type":"application/pdf","success":1,"file_name":"2021_EcologyLetters_CasillasPerez.pdf","checksum":"0bd4210400e9876609b7c538ab4f9a3c","relation":"main_file","creator":"cchlebak","date_updated":"2022-02-03T13:37:11Z","file_size":700087,"date_created":"2022-02-03T13:37:11Z","file_id":"10721"}],"oa":1,"language":[{"iso":"eng"}],"issue":"1","citation":{"apa":"Casillas Perez, B. E., Pull, C., Naiser, F., Naderlinger, E., Matas, J., &#38; Cremer, S. (2022). Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. <i>Ecology Letters</i>. Wiley. <a href=\"https://doi.org/10.1111/ele.13907\">https://doi.org/10.1111/ele.13907</a>","mla":"Casillas Perez, Barbara E., et al. “Early Queen Infection Shapes Developmental Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.” <i>Ecology Letters</i>, vol. 25, no. 1, Wiley, 2022, pp. 89–100, doi:<a href=\"https://doi.org/10.1111/ele.13907\">10.1111/ele.13907</a>.","chicago":"Casillas Perez, Barbara E, Christopher Pull, Filip Naiser, Elisabeth Naderlinger, Jiri Matas, and Sylvia Cremer. “Early Queen Infection Shapes Developmental Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.” <i>Ecology Letters</i>. Wiley, 2022. <a href=\"https://doi.org/10.1111/ele.13907\">https://doi.org/10.1111/ele.13907</a>.","ista":"Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. 2022. Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. Ecology Letters. 25(1), 89–100.","ieee":"B. E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, and S. Cremer, “Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies,” <i>Ecology Letters</i>, vol. 25, no. 1. Wiley, pp. 89–100, 2022.","short":"B.E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, S. Cremer, Ecology Letters 25 (2022) 89–100.","ama":"Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. <i>Ecology Letters</i>. 2022;25(1):89-100. doi:<a href=\"https://doi.org/10.1111/ele.13907\">10.1111/ele.13907</a>"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1111/ele.13907","article_processing_charge":"Yes (via OA deal)","publisher":"Wiley","date_updated":"2023-08-14T11:45:29Z","_id":"10284","type":"journal_article","page":"89-100","ddc":["573"],"quality_controlled":"1","isi":1,"year":"2022","external_id":{"isi":["000713396100001"],"pmid":["34725912"]},"related_material":{"record":[{"relation":"research_data","status":"public","id":"13061"}]},"project":[{"name":"Epidemics in ant societies on a chip","grant_number":"771402","call_identifier":"H2020","_id":"2649B4DE-B435-11E9-9278-68D0E5697425"}],"status":"public","publication":"Ecology Letters","pmid":1,"ec_funded":1,"date_published":"2022-01-01T00:00:00Z","acknowledgement":"The authors are grateful to G. Tkačik and V. Mireles for advice on data analyses and to A. Schloegl for help using the IST Austria HPC cluster for data processing. The authors thank J. Eilenberg for providing the fungal strain and A.V. Grasse for support with the molecular analysis. The authors also thank the Social Immunity group at IST Austria, in particular B. Milutinović, for discussions throughout and comments on the manuscript."},{"publisher":"Springer Nature","doi":"10.1038/s41577-022-00797-y","article_processing_charge":"No","type":"journal_article","date_updated":"2023-08-04T08:53:32Z","_id":"12133","page":"713-714","quality_controlled":"1","external_id":{"pmid":["36284178"],"isi":["000871836300001"]},"isi":1,"year":"2022","keyword":["Energy Engineering and Power Technology","Fuel Technology"],"publication":"Nature Reviews Immunology","status":"public","date_published":"2022-12-01T00:00:00Z","pmid":1,"oa_version":"None","title":"Principles of disease defence in organisms, superorganisms and societies","author":[{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","last_name":"Cremer","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179"}],"day":"01","scopus_import":"1","article_type":"letter_note","date_created":"2023-01-12T12:03:14Z","volume":22,"abstract":[{"lang":"eng","text":"Social distancing is an effective way to prevent the spread of disease in societies, whereas infection elimination is a key element of organismal immunity. Here, we discuss how the study of social insects such as ants — which form a superorganism of unconditionally cooperative individuals and thus represent a level of organization that is intermediate between a classical society of individuals and an organism of cells — can help to determine common principles of disease defence across levels of organization."}],"intvolume":"        22","publication_identifier":{"eissn":["1474-1741"],"issn":["1474-1733"]},"publication_status":"published","month":"12","department":[{"_id":"SyCr"},{"_id":"MiSi"}],"language":[{"iso":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"12","citation":{"ama":"Cremer S, Sixt MK. Principles of disease defence in organisms, superorganisms and societies. <i>Nature Reviews Immunology</i>. 2022;22(12):713-714. doi:<a href=\"https://doi.org/10.1038/s41577-022-00797-y\">10.1038/s41577-022-00797-y</a>","ieee":"S. Cremer and M. K. Sixt, “Principles of disease defence in organisms, superorganisms and societies,” <i>Nature Reviews Immunology</i>, vol. 22, no. 12. Springer Nature, pp. 713–714, 2022.","short":"S. Cremer, M.K. Sixt, Nature Reviews Immunology 22 (2022) 713–714.","chicago":"Cremer, Sylvia, and Michael K Sixt. “Principles of Disease Defence in Organisms, Superorganisms and Societies.” <i>Nature Reviews Immunology</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41577-022-00797-y\">https://doi.org/10.1038/s41577-022-00797-y</a>.","ista":"Cremer S, Sixt MK. 2022. Principles of disease defence in organisms, superorganisms and societies. Nature Reviews Immunology. 22(12), 713–714.","apa":"Cremer, S., &#38; Sixt, M. K. (2022). Principles of disease defence in organisms, superorganisms and societies. <i>Nature Reviews Immunology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41577-022-00797-y\">https://doi.org/10.1038/s41577-022-00797-y</a>","mla":"Cremer, Sylvia, and Michael K. Sixt. “Principles of Disease Defence in Organisms, Superorganisms and Societies.” <i>Nature Reviews Immunology</i>, vol. 22, no. 12, Springer Nature, 2022, pp. 713–14, doi:<a href=\"https://doi.org/10.1038/s41577-022-00797-y\">10.1038/s41577-022-00797-y</a>."}},{"ec_funded":1,"citation":{"apa":"Casillas Perez, B. E., Pull, C., Naiser, F., Naderlinger, E., Matas, J., &#38; Cremer, S. (2021). Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. Dryad. <a href=\"https://doi.org/10.5061/DRYAD.7PVMCVDTJ\">https://doi.org/10.5061/DRYAD.7PVMCVDTJ</a>","mla":"Casillas Perez, Barbara E., et al. <i>Early Queen Infection Shapes Developmental Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies</i>. Dryad, 2021, doi:<a href=\"https://doi.org/10.5061/DRYAD.7PVMCVDTJ\">10.5061/DRYAD.7PVMCVDTJ</a>.","ista":"Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. 2021. Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.7PVMCVDTJ\">10.5061/DRYAD.7PVMCVDTJ</a>.","chicago":"Casillas Perez, Barbara E, Christopher Pull, Filip Naiser, Elisabeth Naderlinger, Jiri Matas, and Sylvia Cremer. “Early Queen Infection Shapes Developmental Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.” Dryad, 2021. <a href=\"https://doi.org/10.5061/DRYAD.7PVMCVDTJ\">https://doi.org/10.5061/DRYAD.7PVMCVDTJ</a>.","ieee":"B. E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, and S. Cremer, “Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies.” Dryad, 2021.","short":"B.E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, S. Cremer, (2021).","ama":"Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. 2021. doi:<a href=\"https://doi.org/10.5061/DRYAD.7PVMCVDTJ\">10.5061/DRYAD.7PVMCVDTJ</a>"},"date_published":"2021-10-29T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"project":[{"call_identifier":"H2020","name":"Epidemics in ant societies on a chip","grant_number":"771402","_id":"2649B4DE-B435-11E9-9278-68D0E5697425"}],"status":"public","department":[{"_id":"SyCr"}],"year":"2021","month":"10","related_material":{"record":[{"id":"10284","status":"public","relation":"used_in_publication"}]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.7pvmcvdtj"}],"tmp":{"name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png","short":"CC0 (1.0)"},"abstract":[{"text":"Infections early in life can have enduring effects on an organism’s development and immunity. In this study, we show that this equally applies to developing “superorganisms” – incipient social insect colonies. When we exposed newly mated Lasius niger ant queens to a low pathogen dose, their colonies grew more slowly than controls before winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation survival improved when the ratio of pupae to workers was small. Queens that reared fewer pupae before worker emergence exhibited lower pathogen levels, indicating that high brood rearing efforts interfere with the ability of the queen’s immune system to suppress pathogen proliferation. Early-life queen pathogen-exposure also improved the immunocompetence of her worker offspring, as demonstrated by challenging the workers to the same pathogen a year later. Transgenerational transfer of the queen’s pathogen experience to her workforce can hence durably reduce the disease susceptibility of the whole superorganism.","lang":"eng"}],"ddc":["570"],"date_updated":"2023-08-14T11:45:28Z","_id":"13061","type":"research_data_reference","date_created":"2023-05-23T16:14:35Z","author":[{"full_name":"Casillas Perez, Barbara E","id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","last_name":"Casillas Perez","first_name":"Barbara E"},{"first_name":"Christopher","orcid":"0000-0003-1122-3982","full_name":"Pull, Christopher","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","last_name":"Pull"},{"first_name":"Filip","last_name":"Naiser","full_name":"Naiser, Filip"},{"first_name":"Elisabeth","full_name":"Naderlinger, Elisabeth","last_name":"Naderlinger"},{"last_name":"Matas","full_name":"Matas, Jiri","first_name":"Jiri"},{"first_name":"Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"doi":"10.5061/DRYAD.7PVMCVDTJ","day":"29","article_processing_charge":"No","publisher":"Dryad","oa_version":"Published Version","title":"Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies"},{"oa_version":"Published Version","title":"Social immunity modulates competition between coinfecting pathogens","day":"01","scopus_import":"1","author":[{"last_name":"Milutinovic","full_name":"Milutinovic, Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara","orcid":"0000-0002-8214-4758"},{"first_name":"Miriam","id":"42462816-F248-11E8-B48F-1D18A9856A87","full_name":"Stock, Miriam","last_name":"Stock"},{"first_name":"Anna V","last_name":"Grasse","full_name":"Grasse, Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Elisabeth","last_name":"Naderlinger","id":"31757262-F248-11E8-B48F-1D18A9856A87","full_name":"Naderlinger, Elisabeth"},{"last_name":"Hilbe","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87","full_name":"Hilbe, Christian","orcid":"0000-0001-5116-955X","first_name":"Christian"},{"first_name":"Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","last_name":"Cremer"}],"date_created":"2020-01-20T13:32:12Z","article_type":"letter_note","volume":23,"acknowledged_ssus":[{"_id":"LifeSc"}],"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"abstract":[{"text":"Coinfections with multiple pathogens can result in complex within‐host dynamics affecting virulence and transmission. While multiple infections are intensively studied in solitary hosts, it is so far unresolved how social host interactions interfere with pathogen competition, and if this depends on coinfection diversity. We studied how the collective disease defences of ants – their social immunity – influence pathogen competition in coinfections of same or different fungal pathogen species. Social immunity reduced virulence for all pathogen combinations, but interfered with spore production only in different‐species coinfections. Here, it decreased overall pathogen sporulation success while increasing co‐sporulation on individual cadavers and maintaining a higher pathogen diversity at the community level. Mathematical modelling revealed that host sanitary care alone can modulate competitive outcomes between pathogens, giving advantage to fast‐germinating, thus less grooming‐sensitive ones. Host social interactions can hence modulate infection dynamics in coinfected group members, thereby altering pathogen communities at the host level and population level.","lang":"eng"}],"intvolume":"        23","has_accepted_license":"1","file_date_updated":"2020-11-19T11:27:10Z","publication_identifier":{"eissn":["1461-0248"],"issn":["1461-023X"]},"publication_status":"published","month":"03","file":[{"access_level":"open_access","content_type":"application/pdf","success":1,"file_name":"2020_EcologyLetters_Milutinovic.pdf","checksum":"0cd8be386fa219db02845b7c3991ce04","relation":"main_file","creator":"dernst","date_updated":"2020-11-19T11:27:10Z","file_size":561749,"date_created":"2020-11-19T11:27:10Z","file_id":"8776"}],"department":[{"_id":"SyCr"},{"_id":"KrCh"}],"language":[{"iso":"eng"}],"oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ama":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. Social immunity modulates competition between coinfecting pathogens. <i>Ecology Letters</i>. 2020;23(3):565-574. doi:<a href=\"https://doi.org/10.1111/ele.13458\">10.1111/ele.13458</a>","short":"B. Milutinovic, M. Stock, A.V. Grasse, E. Naderlinger, C. Hilbe, S. Cremer, Ecology Letters 23 (2020) 565–574.","ieee":"B. Milutinovic, M. Stock, A. V. Grasse, E. Naderlinger, C. Hilbe, and S. Cremer, “Social immunity modulates competition between coinfecting pathogens,” <i>Ecology Letters</i>, vol. 23, no. 3. Wiley, pp. 565–574, 2020.","chicago":"Milutinovic, Barbara, Miriam Stock, Anna V Grasse, Elisabeth Naderlinger, Christian Hilbe, and Sylvia Cremer. “Social Immunity Modulates Competition between Coinfecting Pathogens.” <i>Ecology Letters</i>. Wiley, 2020. <a href=\"https://doi.org/10.1111/ele.13458\">https://doi.org/10.1111/ele.13458</a>.","ista":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. 2020. Social immunity modulates competition between coinfecting pathogens. Ecology Letters. 23(3), 565–574.","mla":"Milutinovic, Barbara, et al. “Social Immunity Modulates Competition between Coinfecting Pathogens.” <i>Ecology Letters</i>, vol. 23, no. 3, Wiley, 2020, pp. 565–74, doi:<a href=\"https://doi.org/10.1111/ele.13458\">10.1111/ele.13458</a>.","apa":"Milutinovic, B., Stock, M., Grasse, A. V., Naderlinger, E., Hilbe, C., &#38; Cremer, S. (2020). Social immunity modulates competition between coinfecting pathogens. <i>Ecology Letters</i>. Wiley. <a href=\"https://doi.org/10.1111/ele.13458\">https://doi.org/10.1111/ele.13458</a>"},"issue":"3","publisher":"Wiley","article_processing_charge":"Yes (via OA deal)","doi":"10.1111/ele.13458","type":"journal_article","_id":"7343","date_updated":"2023-09-05T16:04:49Z","ddc":["570"],"page":"565-574","quality_controlled":"1","related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/social-ants-shapes-disease-outcome/"}],"record":[{"status":"public","relation":"research_data","id":"13060"}]},"external_id":{"isi":["000507515900001"]},"year":"2020","isi":1,"status":"public","publication":"Ecology Letters","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"},{"name":"Host-Parasite Coevolution","grant_number":"CR-118/3-1","_id":"25DAF0B2-B435-11E9-9278-68D0E5697425"}],"date_published":"2020-03-01T00:00:00Z","acknowledgement":"We thank Bernhardt Steinwender and Jorgen Eilenberg for the fungal strains, Xavier Espadaler, Mireia Diaz, Christiane Wanke, Lumi Viljakainen and the Social Immunity Team at IST Austria, for help with ant collection, and Wanda Gorecka and Gertraud Stift of the IST Austria Life Science Facility for technical support. We are thankful to Dieter Ebert for input at all stages of the project, Roger Mundry for statistical advice, Hinrich Schulenburg, Paul Schmid-Hempel, Yuko\r\nUlrich and Joachim Kurtz for project discussion, Bor Kavcic for advice on growth curves, Marcus Roper for advice on modelling work and comments on the manuscript, as well as Marjon de Vos, Weini Huang and the Social Immunity Team for comments on the manuscript.\r\nThis study was funded by the German Research Foundation (DFG) within the Priority Programme 1399 Host-parasite Coevolution (CR 118/3 to S.C.) and the People Programme\r\n(Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no 291734 (ISTFELLOW to B.M.). ","ec_funded":1},{"oa":1,"status":"public","citation":{"ista":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. 2020. Social immunity modulates competition between coinfecting pathogens, Dryad, <a href=\"https://doi.org/10.5061/DRYAD.CRJDFN318\">10.5061/DRYAD.CRJDFN318</a>.","chicago":"Milutinovic, Barbara, Miriam Stock, Anna V Grasse, Elisabeth Naderlinger, Christian Hilbe, and Sylvia Cremer. “Social Immunity Modulates Competition between Coinfecting Pathogens.” Dryad, 2020. <a href=\"https://doi.org/10.5061/DRYAD.CRJDFN318\">https://doi.org/10.5061/DRYAD.CRJDFN318</a>.","mla":"Milutinovic, Barbara, et al. <i>Social Immunity Modulates Competition between Coinfecting Pathogens</i>. Dryad, 2020, doi:<a href=\"https://doi.org/10.5061/DRYAD.CRJDFN318\">10.5061/DRYAD.CRJDFN318</a>.","apa":"Milutinovic, B., Stock, M., Grasse, A. V., Naderlinger, E., Hilbe, C., &#38; Cremer, S. (2020). Social immunity modulates competition between coinfecting pathogens. Dryad. <a href=\"https://doi.org/10.5061/DRYAD.CRJDFN318\">https://doi.org/10.5061/DRYAD.CRJDFN318</a>","ama":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. Social immunity modulates competition between coinfecting pathogens. 2020. doi:<a href=\"https://doi.org/10.5061/DRYAD.CRJDFN318\">10.5061/DRYAD.CRJDFN318</a>","short":"B. Milutinovic, M. Stock, A.V. Grasse, E. Naderlinger, C. Hilbe, S. Cremer, (2020).","ieee":"B. Milutinovic, M. Stock, A. V. Grasse, E. Naderlinger, C. Hilbe, and S. Cremer, “Social immunity modulates competition between coinfecting pathogens.” Dryad, 2020."},"date_published":"2020-12-19T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2020","month":"12","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"7343"}]},"department":[{"_id":"SyCr"},{"_id":"KrCh"}],"tmp":{"name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","image":"/images/cc_0.png","short":"CC0 (1.0)"},"abstract":[{"lang":"eng","text":"Coinfections with multiple pathogens can result in complex within-host dynamics affecting virulence and transmission. Whilst multiple infections are intensively studied in solitary hosts, it is so far unresolved how social host interactions interfere with pathogen competition, and if this depends on coinfection diversity. We studied how the collective disease defenses of ants – their social immunity ­– influence pathogen competition in coinfections of same or different fungal pathogen species. Social immunity reduced virulence for all pathogen combinations, but interfered with spore production only in different-species coinfections. Here, it decreased overall pathogen sporulation success, whilst simultaneously increasing co-sporulation on individual cadavers and maintaining a higher pathogen diversity at the community-level. Mathematical modeling revealed that host sanitary care alone can modulate competitive outcomes between pathogens, giving advantage to fast-germinating, thus less grooming-sensitive ones. Host social interactions can hence modulate infection dynamics in coinfected group members, thereby altering pathogen communities at the host- and population-level."}],"ddc":["570"],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.crjdfn318"}],"author":[{"first_name":"Barbara","orcid":"0000-0002-8214-4758","last_name":"Milutinovic","full_name":"Milutinovic, Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Miriam","last_name":"Stock","id":"42462816-F248-11E8-B48F-1D18A9856A87","full_name":"Stock, Miriam"},{"first_name":"Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","full_name":"Grasse, Anna V","last_name":"Grasse"},{"first_name":"Elisabeth","last_name":"Naderlinger","id":"31757262-F248-11E8-B48F-1D18A9856A87","full_name":"Naderlinger, Elisabeth"},{"first_name":"Christian","orcid":"0000-0001-5116-955X","full_name":"Hilbe, Christian","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87","last_name":"Hilbe"},{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","last_name":"Cremer","first_name":"Sylvia","orcid":"0000-0002-2193-3868"}],"doi":"10.5061/DRYAD.CRJDFN318","day":"19","article_processing_charge":"No","publisher":"Dryad","oa_version":"Published Version","title":"Social immunity modulates competition between coinfecting pathogens","date_updated":"2023-09-05T16:04:48Z","_id":"13060","type":"research_data_reference","date_created":"2023-05-23T16:11:22Z"},{"quality_controlled":"1","publication_status":"published","publication_identifier":{"isbn":["9783319903064"]},"date_updated":"2021-02-05T12:19:21Z","_id":"9096","type":"book_chapter","date_created":"2021-02-05T12:15:18Z","doi":"10.1007/978-3-319-90306-4_94-1","author":[{"full_name":"Schmid-Hempel, Paul","last_name":"Schmid-Hempel","first_name":"Paul"},{"orcid":"0000-0002-2193-3868","first_name":"Sylvia M","full_name":"Cremer, Sylvia M","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer"}],"article_processing_charge":"No","day":"22","editor":[{"full_name":"Starr, C","last_name":"Starr","first_name":"C"}],"oa_version":"None","title":"Parasites and Pathogens","publisher":"Springer Nature","place":"Cham","citation":{"ama":"Schmid-Hempel P, Cremer S. Parasites and Pathogens. In: Starr C, ed. <i>Encyclopedia of Social Insects</i>. Cham: Springer Nature; 2020. doi:<a href=\"https://doi.org/10.1007/978-3-319-90306-4_94-1\">10.1007/978-3-319-90306-4_94-1</a>","short":"P. Schmid-Hempel, S. Cremer, in:, C. Starr (Ed.), Encyclopedia of Social Insects, Springer Nature, Cham, 2020.","ieee":"P. Schmid-Hempel and S. Cremer, “Parasites and Pathogens,” in <i>Encyclopedia of Social Insects</i>, C. Starr, Ed. Cham: Springer Nature, 2020.","ista":"Schmid-Hempel P, Cremer S. 2020.Parasites and Pathogens. In: Encyclopedia of Social Insects. .","chicago":"Schmid-Hempel, Paul, and Sylvia Cremer. “Parasites and Pathogens.” In <i>Encyclopedia of Social Insects</i>, edited by C Starr. Cham: Springer Nature, 2020. <a href=\"https://doi.org/10.1007/978-3-319-90306-4_94-1\">https://doi.org/10.1007/978-3-319-90306-4_94-1</a>.","mla":"Schmid-Hempel, Paul, and Sylvia Cremer. “Parasites and Pathogens.” <i>Encyclopedia of Social Insects</i>, edited by C Starr, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1007/978-3-319-90306-4_94-1\">10.1007/978-3-319-90306-4_94-1</a>.","apa":"Schmid-Hempel, P., &#38; Cremer, S. (2020). Parasites and Pathogens. In C. Starr (Ed.), <i>Encyclopedia of Social Insects</i>. Cham: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-319-90306-4_94-1\">https://doi.org/10.1007/978-3-319-90306-4_94-1</a>"},"date_published":"2020-02-22T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","language":[{"iso":"eng"}],"publication":"Encyclopedia of Social Insects","department":[{"_id":"SyCr"}],"year":"2020","month":"02"},{"quality_controlled":"1","publication_status":"published","publication_identifier":{"isbn":["9780128132517"],"eisbn":["9780128132524"]},"page":"747-755","abstract":[{"lang":"eng","text":"Social insects (i.e., ants, termites and the social bees and wasps) protect their colonies from disease using a combination of individual immunity and collectively performed defenses, termed social immunity. The first line of social immune defense is sanitary care, which is performed by colony members to protect their pathogen-exposed nestmates from developing an infection. If sanitary care fails and an infection becomes established, a second line of social immune defense is deployed to stop disease transmission within the colony and to protect the valuable queens, which together with the males are the reproductive individuals of the colony. Insect colonies are separated into these reproductive individuals and the sterile worker force, forming a superorganismal reproductive unit reminiscent of the differentiated germline and soma in a multicellular organism. Ultimately, the social immune response preserves the germline of the superorganism insect colony and increases overall fitness of the colony in case of disease. "}],"edition":"2","_id":"7513","date_updated":"2023-09-08T11:12:04Z","date_created":"2020-02-23T23:00:36Z","type":"book_chapter","scopus_import":"1","article_processing_charge":"No","day":"06","author":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","last_name":"Cremer","first_name":"Sylvia","orcid":"0000-0002-2193-3868"},{"orcid":"0000-0002-8696-6978","first_name":"Megan","full_name":"Kutzer, Megan","id":"29D0B332-F248-11E8-B48F-1D18A9856A87","last_name":"Kutzer"}],"doi":"10.1016/B978-0-12-809633-8.90721-0","title":"Social immunity","publisher":"Elsevier","oa_version":"None","editor":[{"first_name":"Jae","full_name":"Choe, Jae","last_name":"Choe"}],"citation":{"chicago":"Cremer, Sylvia, and Megan Kutzer. “Social Immunity.” In <i>Encyclopedia of Animal Behavior</i>, edited by Jae Choe, 2nd ed., 747–55. Elsevier, 2019. <a href=\"https://doi.org/10.1016/B978-0-12-809633-8.90721-0\">https://doi.org/10.1016/B978-0-12-809633-8.90721-0</a>.","ista":"Cremer S, Kutzer M. 2019.Social immunity. In: Encyclopedia of Animal Behavior. , 747–755.","apa":"Cremer, S., &#38; Kutzer, M. (2019). Social immunity. In J. Choe (Ed.), <i>Encyclopedia of Animal Behavior</i> (2nd ed., pp. 747–755). Elsevier. <a href=\"https://doi.org/10.1016/B978-0-12-809633-8.90721-0\">https://doi.org/10.1016/B978-0-12-809633-8.90721-0</a>","mla":"Cremer, Sylvia, and Megan Kutzer. “Social Immunity.” <i>Encyclopedia of Animal Behavior</i>, edited by Jae Choe, 2nd ed., Elsevier, 2019, pp. 747–55, doi:<a href=\"https://doi.org/10.1016/B978-0-12-809633-8.90721-0\">10.1016/B978-0-12-809633-8.90721-0</a>.","ama":"Cremer S, Kutzer M. Social immunity. In: Choe J, ed. <i>Encyclopedia of Animal Behavior</i>. 2nd ed. Elsevier; 2019:747-755. doi:<a href=\"https://doi.org/10.1016/B978-0-12-809633-8.90721-0\">10.1016/B978-0-12-809633-8.90721-0</a>","ieee":"S. Cremer and M. Kutzer, “Social immunity,” in <i>Encyclopedia of Animal Behavior</i>, 2nd ed., J. Choe, Ed. Elsevier, 2019, pp. 747–755.","short":"S. Cremer, M. Kutzer, in:, J. Choe (Ed.), Encyclopedia of Animal Behavior, 2nd ed., Elsevier, 2019, pp. 747–755."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_published":"2019-02-06T00:00:00Z","language":[{"iso":"eng"}],"status":"public","publication":"Encyclopedia of Animal Behavior","department":[{"_id":"SyCr"}],"isi":1,"year":"2019","month":"02","external_id":{"isi":["000248989500026"]}},{"quality_controlled":"1","publication_status":"published","publication_identifier":{"eissn":["22145753"],"issn":["22145745"]},"intvolume":"        33","abstract":[{"lang":"eng","text":"Ant invasions are often harmful to native species communities. Their pathogens and host disease defense mechanisms may be one component of their devastating success. First, they can introduce harmful diseases to their competitors in the introduced range, to which they themselves are tolerant. Second, their supercolonial social structure of huge multi-queen nest networks means that they will harbor a broad pathogen spectrum and high pathogen load while remaining resilient, unlike the smaller, territorial colonies of the native species. Thus, it is likely that invasive ants act as a disease reservoir, promoting their competitive advantage and invasive success."}],"page":"63-68","type":"journal_article","date_created":"2019-05-13T07:58:36Z","date_updated":"2023-08-25T10:31:31Z","volume":33,"_id":"6415","oa_version":"None","title":"Pathogens and disease defense of invasive ants","publisher":"Elsevier","author":[{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer"}],"doi":"10.1016/j.cois.2019.03.011","article_processing_charge":"No","day":"01","scopus_import":"1","date_published":"2019-06-01T00:00:00Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"mla":"Cremer, Sylvia. “Pathogens and Disease Defense of Invasive Ants.” <i>Current Opinion in Insect Science</i>, vol. 33, Elsevier, 2019, pp. 63–68, doi:<a href=\"https://doi.org/10.1016/j.cois.2019.03.011\">10.1016/j.cois.2019.03.011</a>.","apa":"Cremer, S. (2019). Pathogens and disease defense of invasive ants. <i>Current Opinion in Insect Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cois.2019.03.011\">https://doi.org/10.1016/j.cois.2019.03.011</a>","chicago":"Cremer, Sylvia. “Pathogens and Disease Defense of Invasive Ants.” <i>Current Opinion in Insect Science</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.cois.2019.03.011\">https://doi.org/10.1016/j.cois.2019.03.011</a>.","ista":"Cremer S. 2019. Pathogens and disease defense of invasive ants. Current Opinion in Insect Science. 33, 63–68.","short":"S. Cremer, Current Opinion in Insect Science 33 (2019) 63–68.","ieee":"S. Cremer, “Pathogens and disease defense of invasive ants,” <i>Current Opinion in Insect Science</i>, vol. 33. Elsevier, pp. 63–68, 2019.","ama":"Cremer S. Pathogens and disease defense of invasive ants. <i>Current Opinion in Insect Science</i>. 2019;33:63-68. doi:<a href=\"https://doi.org/10.1016/j.cois.2019.03.011\">10.1016/j.cois.2019.03.011</a>"},"status":"public","publication":"Current Opinion in Insect Science","language":[{"iso":"eng"}],"department":[{"_id":"SyCr"}],"external_id":{"isi":["000477666000012"]},"month":"06","isi":1,"year":"2019"},{"department":[{"_id":"SyCr"}],"month":"06","issue":"11","citation":{"mla":"Cremer, Sylvia. “Social Immunity in Insects.” <i>Current Biology</i>, vol. 29, no. 11, Elsevier, 2019, pp. R458–63, doi:<a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">10.1016/j.cub.2019.03.035</a>.","apa":"Cremer, S. (2019). Social immunity in insects. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">https://doi.org/10.1016/j.cub.2019.03.035</a>","ista":"Cremer S. 2019. Social immunity in insects. Current Biology. 29(11), R458–R463.","chicago":"Cremer, Sylvia. “Social Immunity in Insects.” <i>Current Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">https://doi.org/10.1016/j.cub.2019.03.035</a>.","short":"S. Cremer, Current Biology 29 (2019) R458–R463.","ieee":"S. Cremer, “Social immunity in insects,” <i>Current Biology</i>, vol. 29, no. 11. Elsevier, pp. R458–R463, 2019.","ama":"Cremer S. Social immunity in insects. <i>Current Biology</i>. 2019;29(11):R458-R463. doi:<a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">10.1016/j.cub.2019.03.035</a>"},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"language":[{"iso":"eng"}],"volume":29,"article_type":"original","date_created":"2019-06-09T21:59:10Z","author":[{"orcid":"0000-0002-2193-3868","first_name":"Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia"}],"scopus_import":"1","day":"03","title":"Social immunity in insects","oa_version":"Published Version","publication_status":"published","publication_identifier":{"issn":["09609822"]},"intvolume":"        29","abstract":[{"text":"When animals become sick, infected cells and an armada of activated immune cells attempt to eliminate the pathogen from the body. Once infectious particles have breached the body's physical barriers of the skin or gut lining, an initially local response quickly escalates into a systemic response, attracting mobile immune cells to the site of infection. These cells complement the initial, unspecific defense with a more specialized, targeted response. This can also provide long-term immune memory and protection against future infection. The cell-autonomous defenses of the infected cells are thus aided by the actions of recruited immune cells. These specialized cells are the most mobile cells in the body, constantly patrolling through the otherwise static tissue to detect incoming pathogens. Such constant immune surveillance means infections are noticed immediately and can be rapidly cleared from the body. Some immune cells also remove infected cells that have succumbed to infection. All this prevents pathogen replication and spread to healthy tissues. Although this may involve the sacrifice of some somatic tissue, this is typically replaced quickly. Particular care is, however, given to the reproductive organs, which should always remain disease free (immune privilege). ","lang":"eng"}],"year":"2019","isi":1,"external_id":{"pmid":["31163158"],"isi":["000470902000023"]},"pmid":1,"date_published":"2019-06-03T00:00:00Z","status":"public","publication":"Current Biology","date_updated":"2023-08-28T09:38:00Z","_id":"6552","type":"journal_article","doi":"10.1016/j.cub.2019.03.035","article_processing_charge":"No","publisher":"Elsevier","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cub.2019.03.035"}],"quality_controlled":"1","page":"R458-R463"},{"article_processing_charge":"No","doi":"10.1002/ece3.4573","publisher":"Wiley","_id":"29","date_updated":"2023-09-19T09:29:12Z","type":"journal_article","page":"11031-11070","ddc":["576","591"],"quality_controlled":"1","year":"2018","isi":1,"external_id":{"isi":["000451611000032"]},"publist_id":"8026","publication":"Ecology and Evolution","status":"public","date_published":"2018-11-01T00:00:00Z","day":"01","scopus_import":"1","author":[{"full_name":"Viljakainen, Lumi","last_name":"Viljakainen","first_name":"Lumi"},{"first_name":"Jaana","last_name":"Jurvansuu","full_name":"Jurvansuu, Jaana"},{"last_name":"Holmberg","full_name":"Holmberg, Ida","first_name":"Ida"},{"last_name":"Pamminger","full_name":"Pamminger, Tobias","first_name":"Tobias"},{"first_name":"Silvio","last_name":"Erler","full_name":"Erler, Silvio"},{"first_name":"Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"title":"Social environment affects the transcriptomic response to bacteria in ant queens","oa_version":"Published Version","volume":8,"date_created":"2018-12-11T11:44:15Z","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"abstract":[{"text":"Social insects have evolved enormous capacities to collectively build nests and defend their colonies against both predators and pathogens. The latter is achieved by a combination of individual immune responses and sophisticated collective behavioral and organizational disease defenses, that is, social immunity. We investigated how the presence or absence of these social defense lines affects individual-level immunity in ant queens after bacterial infection. To this end, we injected queens of the ant Linepithema humile with a mix of gram+ and gram− bacteria or a control solution, reared them either with workers or alone and analyzed their gene expression patterns at 2, 4, 8, and 12 hr post-injection, using RNA-seq. This allowed us to test for the effect of bacterial infection, social context, as well as the interaction between the two over the course of infection and raising of an immune response. We found that social isolation per se affected queen gene expression for metabolism genes, but not for immune genes. When infected, queens reared with and without workers up-regulated similar numbers of innate immune genes revealing activation of Toll and Imd signaling pathways and melanization. Interestingly, however, they mostly regulated different genes along the pathways and showed a different pattern of overall gene up-regulation or down-regulation. Hence, we can conclude that the absence of workers does not compromise the onset of an individual immune response by the queens, but that the social environment impacts the route of the individual innate immune responses.","lang":"eng"}],"intvolume":"         8","file_date_updated":"2020-07-14T12:45:52Z","publication_identifier":{"issn":["20457758"]},"publication_status":"published","month":"11","department":[{"_id":"SyCr"}],"file":[{"content_type":"application/pdf","access_level":"open_access","file_name":"Viljakainen_et_al-2018-Ecology_and_Evolution.pdf","checksum":"0d1355c78627ca7210aadd9a17a01915","relation":"main_file","date_updated":"2020-07-14T12:45:52Z","creator":"dernst","file_size":1272096,"date_created":"2018-12-17T08:27:04Z","file_id":"5682"}],"oa":1,"language":[{"iso":"eng"}],"citation":{"ista":"Viljakainen L, Jurvansuu J, Holmberg I, Pamminger T, Erler S, Cremer S. 2018. Social environment affects the transcriptomic response to bacteria in ant queens. Ecology and Evolution. 8(22), 11031–11070.","chicago":"Viljakainen, Lumi, Jaana Jurvansuu, Ida Holmberg, Tobias Pamminger, Silvio Erler, and Sylvia Cremer. “Social Environment Affects the Transcriptomic Response to Bacteria in Ant Queens.” <i>Ecology and Evolution</i>. Wiley, 2018. <a href=\"https://doi.org/10.1002/ece3.4573\">https://doi.org/10.1002/ece3.4573</a>.","mla":"Viljakainen, Lumi, et al. “Social Environment Affects the Transcriptomic Response to Bacteria in Ant Queens.” <i>Ecology and Evolution</i>, vol. 8, no. 22, Wiley, 2018, pp. 11031–70, doi:<a href=\"https://doi.org/10.1002/ece3.4573\">10.1002/ece3.4573</a>.","apa":"Viljakainen, L., Jurvansuu, J., Holmberg, I., Pamminger, T., Erler, S., &#38; Cremer, S. (2018). Social environment affects the transcriptomic response to bacteria in ant queens. <i>Ecology and Evolution</i>. Wiley. <a href=\"https://doi.org/10.1002/ece3.4573\">https://doi.org/10.1002/ece3.4573</a>","ama":"Viljakainen L, Jurvansuu J, Holmberg I, Pamminger T, Erler S, Cremer S. Social environment affects the transcriptomic response to bacteria in ant queens. <i>Ecology and Evolution</i>. 2018;8(22):11031-11070. doi:<a href=\"https://doi.org/10.1002/ece3.4573\">10.1002/ece3.4573</a>","short":"L. Viljakainen, J. Jurvansuu, I. Holmberg, T. Pamminger, S. Erler, S. Cremer, Ecology and Evolution 8 (2018) 11031–11070.","ieee":"L. Viljakainen, J. Jurvansuu, I. Holmberg, T. Pamminger, S. Erler, and S. Cremer, “Social environment affects the transcriptomic response to bacteria in ant queens,” <i>Ecology and Evolution</i>, vol. 8, no. 22. Wiley, pp. 11031–11070, 2018."},"issue":"22","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"date_created":"2018-12-11T11:48:36Z","volume":63,"title":"Social immunity: Emergence and evolution of colony-level disease protection","oa_version":"None","day":"07","scopus_import":"1","author":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","last_name":"Cremer","orcid":"0000-0002-2193-3868","first_name":"Sylvia"},{"full_name":"Pull, Christopher","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","last_name":"Pull","first_name":"Christopher","orcid":"0000-0003-1122-3982"},{"full_name":"Fürst, Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87","last_name":"Fürst","orcid":"0000-0002-3712-925X","first_name":"Matthias"}],"publication_identifier":{"issn":["1545-4487"]},"publication_status":"published","abstract":[{"text":"Social insect colonies have evolved many collectively performed adaptations that reduce the impact of infectious disease and that are expected to maximize their fitness. This colony-level protection is termed social immunity, and it enhances the health and survival of the colony. In this review, we address how social immunity emerges from its mechanistic components to produce colony-level disease avoidance, resistance, and tolerance. To understand the evolutionary causes and consequences of social immunity, we highlight the need for studies that evaluate the effects of social immunity on colony fitness. We discuss the role that host life history and ecology have on predicted eco-evolutionary dynamics, which differ among the social insect lineages. Throughout the review, we highlight current gaps in our knowledge and promising avenues for future research, which we hope will bring us closer to an integrated understanding of socio-eco-evo-immunology.","lang":"eng"}],"intvolume":"        63","department":[{"_id":"SyCr"}],"month":"01","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ieee":"S. Cremer, C. Pull, and M. Fürst, “Social immunity: Emergence and evolution of colony-level disease protection,” <i>Annual Review of Entomology</i>, vol. 63. Annual Reviews, pp. 105–123, 2018.","short":"S. Cremer, C. Pull, M. Fürst, Annual Review of Entomology 63 (2018) 105–123.","ama":"Cremer S, Pull C, Fürst M. Social immunity: Emergence and evolution of colony-level disease protection. <i>Annual Review of Entomology</i>. 2018;63:105-123. doi:<a href=\"https://doi.org/10.1146/annurev-ento-020117-043110\">10.1146/annurev-ento-020117-043110</a>","apa":"Cremer, S., Pull, C., &#38; Fürst, M. (2018). Social immunity: Emergence and evolution of colony-level disease protection. <i>Annual Review of Entomology</i>. Annual Reviews. <a href=\"https://doi.org/10.1146/annurev-ento-020117-043110\">https://doi.org/10.1146/annurev-ento-020117-043110</a>","mla":"Cremer, Sylvia, et al. “Social Immunity: Emergence and Evolution of Colony-Level Disease Protection.” <i>Annual Review of Entomology</i>, vol. 63, Annual Reviews, 2018, pp. 105–23, doi:<a href=\"https://doi.org/10.1146/annurev-ento-020117-043110\">10.1146/annurev-ento-020117-043110</a>.","chicago":"Cremer, Sylvia, Christopher Pull, and Matthias Fürst. “Social Immunity: Emergence and Evolution of Colony-Level Disease Protection.” <i>Annual Review of Entomology</i>. Annual Reviews, 2018. <a href=\"https://doi.org/10.1146/annurev-ento-020117-043110\">https://doi.org/10.1146/annurev-ento-020117-043110</a>.","ista":"Cremer S, Pull C, Fürst M. 2018. Social immunity: Emergence and evolution of colony-level disease protection. Annual Review of Entomology. 63, 105–123."},"language":[{"iso":"eng"}],"type":"journal_article","_id":"806","date_updated":"2023-09-19T09:29:45Z","publisher":"Annual Reviews","article_processing_charge":"No","doi":"10.1146/annurev-ento-020117-043110","quality_controlled":"1","page":"105 - 123","publist_id":"6844","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"819"}]},"external_id":{"isi":["000424633700008"]},"year":"2018","isi":1,"date_published":"2018-01-07T00:00:00Z","status":"public","publication":"Annual Review of Entomology"}]