---
_id: '13314'
abstract:
- lang: eng
  text: The emergence of large-scale order in self-organized systems relies on local
    interactions between individual components. During bacterial cell division, FtsZ—a
    prokaryotic homologue of the eukaryotic protein tubulin—polymerizes into treadmilling
    filaments that further organize into a cytoskeletal ring. In vitro, FtsZ filaments
    can form dynamic chiral assemblies. However, how the active and passive properties
    of individual filaments relate to these large-scale self-organized structures
    remains poorly understood. Here we connect single-filament properties with the
    mesoscopic scale by combining minimal active matter simulations and biochemical
    reconstitution experiments. We show that the density and flexibility of active
    chiral filaments define their global order. At intermediate densities, curved,
    flexible filaments organize into chiral rings and polar bands. An effectively
    nematic organization dominates for high densities and for straight, mutant filaments
    with increased rigidity. Our predicted phase diagram quantitatively captures these
    features, demonstrating how the flexibility, density and chirality of the active
    filaments affect their collective behaviour. Our findings shed light on the fundamental
    properties of active chiral matter and explain how treadmilling FtsZ filaments
    organize during bacterial cell division.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: 'This work was supported by the European Research Council through
  grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607
  to M.L., B. P.M. was also supported by the Kanazawa University WPI- NanoLSI Bio-SPM
  collaborative research program. Z.D. has received funding from Doctoral Programme
  of the Austrian Academy of Sciences (OeAW): Grant agreement 26360. We thank Jan
  Brugues (MPI CBG, Dresden, Germany), Andela Saric (ISTA, Klosterneuburg, Austria),
  Daniel Pearce (Uni Geneva, Switzerland) for valuable scientific input and comments
  on the manuscript. We are also thankful for the support by the Scientific Service
  Units (SSU) of IST Austria through resources provided by the Imaging and Optics
  Facility (IOF) and the Lab Support Facility (LSF).'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Zuzana
  full_name: Dunajova, Zuzana
  id: 4B39F286-F248-11E8-B48F-1D18A9856A87
  last_name: Dunajova
- first_name: Batirtze
  full_name: Prats Mateu, Batirtze
  id: 299FE892-F248-11E8-B48F-1D18A9856A87
  last_name: Prats Mateu
- first_name: Philipp
  full_name: Radler, Philipp
  id: 40136C2A-F248-11E8-B48F-1D18A9856A87
  last_name: Radler
  orcid: '0000-0001-9198-2182 '
- first_name: Keesiang
  full_name: Lim, Keesiang
  last_name: Lim
- first_name: Dörte
  full_name: Brandis, Dörte
  id: 21d64d35-f128-11eb-9611-b8bcca7a12fd
  last_name: Brandis
- first_name: Philipp
  full_name: Velicky, Philipp
  id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
  last_name: Velicky
  orcid: 0000-0002-2340-7431
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Richard W.
  full_name: Wong, Richard W.
  last_name: Wong
- first_name: Jens
  full_name: Elgeti, Jens
  last_name: Elgeti
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
citation:
  ama: Dunajova Z, Prats Mateu B, Radler P, et al. Chiral and nematic phases of flexible
    active filaments. <i>Nature Physics</i>. 2023;19:1916-1926. doi:<a href="https://doi.org/10.1038/s41567-023-02218-w">10.1038/s41567-023-02218-w</a>
  apa: Dunajova, Z., Prats Mateu, B., Radler, P., Lim, K., Brandis, D., Velicky, P.,
    … Loose, M. (2023). Chiral and nematic phases of flexible active filaments. <i>Nature
    Physics</i>. Springer Nature. <a href="https://doi.org/10.1038/s41567-023-02218-w">https://doi.org/10.1038/s41567-023-02218-w</a>
  chicago: Dunajova, Zuzana, Batirtze Prats Mateu, Philipp Radler, Keesiang Lim, Dörte
    Brandis, Philipp Velicky, Johann G Danzl, et al. “Chiral and Nematic Phases of
    Flexible Active Filaments.” <i>Nature Physics</i>. Springer Nature, 2023. <a href="https://doi.org/10.1038/s41567-023-02218-w">https://doi.org/10.1038/s41567-023-02218-w</a>.
  ieee: Z. Dunajova <i>et al.</i>, “Chiral and nematic phases of flexible active filaments,”
    <i>Nature Physics</i>, vol. 19. Springer Nature, pp. 1916–1926, 2023.
  ista: Dunajova Z, Prats Mateu B, Radler P, Lim K, Brandis D, Velicky P, Danzl JG,
    Wong RW, Elgeti J, Hannezo EB, Loose M. 2023. Chiral and nematic phases of flexible
    active filaments. Nature Physics. 19, 1916–1926.
  mla: Dunajova, Zuzana, et al. “Chiral and Nematic Phases of Flexible Active Filaments.”
    <i>Nature Physics</i>, vol. 19, Springer Nature, 2023, pp. 1916–26, doi:<a href="https://doi.org/10.1038/s41567-023-02218-w">10.1038/s41567-023-02218-w</a>.
  short: Z. Dunajova, B. Prats Mateu, P. Radler, K. Lim, D. Brandis, P. Velicky, J.G.
    Danzl, R.W. Wong, J. Elgeti, E.B. Hannezo, M. Loose, Nature Physics 19 (2023)
    1916–1926.
date_created: 2023-07-27T14:44:45Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2024-02-21T12:19:08Z
day: '01'
ddc:
- '530'
department:
- _id: JoDa
- _id: EdHa
- _id: MaLo
- _id: GradSch
doi: 10.1038/s41567-023-02218-w
ec_funded: 1
external_id:
  pmid:
  - '38075437'
file:
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intvolume: '        19'
language:
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license: https://creativecommons.org/licenses/by/4.0/
month: '12'
oa: 1
oa_version: Published Version
page: 1916-1926
pmid: 1
project:
- _id: 2595697A-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '679239'
  name: Self-Organization of the Bacterial Cell
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
  grant_number: P34607
  name: "Understanding bacterial cell division by in vitro\r\nreconstitution"
- _id: 34d75525-11ca-11ed-8bc3-89b6307fee9d
  grant_number: '26360'
  name: Motile active matter models of migrating cells and chiral filaments
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Chiral and nematic phases of flexible active filaments
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...