---
_id: '13260'
abstract:
- lang: eng
  text: Experimental evolution studies are powerful approaches to examine the evolutionary
    history of lab populations. Such studies have shed light on how selection changes
    phenotypes and genotypes. Most of these studies have not examined the time course
    of adaptation under sexual selection manipulation, by resequencing the populations’
    genomes at multiple time points. Here, we analyze allele frequency trajectories
    in Drosophila pseudoobscura where we altered their sexual selection regime for
    200 generations and sequenced pooled populations at 5 time points. The intensity
    of sexual selection was either relaxed in monogamous populations (M) or elevated
    in polyandrous lines (E). We present a comprehensive study of how selection alters
    population genetics parameters at the chromosome and gene level. We investigate
    differences in the effective population size—Ne—between the treatments, and perform
    a genome-wide scan to identify signatures of selection from the time-series data.
    We found genomic signatures of adaptation to both regimes in D. pseudoobscura.
    There are more significant variants in E lines as expected from stronger sexual
    selection. However, we found that the response on the X chromosome was substantial
    in both treatments, more pronounced in E and restricted to the more recently sex-linked
    chromosome arm XR in M. In the first generations of experimental evolution, we
    estimate Ne to be lower on the X in E lines, which might indicate a swift adaptive
    response at the onset of selection. Additionally, the third chromosome was affected
    by elevated polyandry whereby its distal end harbors a region showing a strong
    signal of adaptive evolution especially in E lines.
acknowledgement: This work was supported by the Vienna Science and Technology Fund
  (WWTF)(10.47379/MA16061). C.K. received funding from the Royal Society (RG170315)
  and the Carnegie Trust (RIG007474). M.G.R. and R.R.S. have been supported by NERC
  (UK) grants NE/I014632/1 and NE/V001566/1. Bioinformatics analyses were performed
  on the computer cluster at the University of St Andrews Bioinformatics Unit, which
  is funded by Wellcome Trust ISSF awards 105621/Z/14/Z. Complementary data parsing
  was carried out with the computational resources provided by the Research/Scientific
  Computing teams at The James Hutton Institute and the National Institute of Agricultural
  Botany (NIAB)—UK’s Crop Diversity Bioinformatics HPC, BBSRC grant BB/S019669/1.
  We are thankful to Paris Veltsos and R. Axel W. Wiberg for useful discussions about
  the project as well as providing us with the resequencing data they had produced
  as a result of previous work on this experiment. We are especially grateful to Tanya
  Sneddon for her help with the DNA extraction process and shipping.
article_number: evad113
article_processing_charge: Yes
article_type: original
author:
- first_name: Carolina
  full_name: De Castro Barbosa Rodrigues Barata, Carolina
  id: 20565186-803f-11ed-ab7e-96a4ff7694ef
  last_name: De Castro Barbosa Rodrigues Barata
- first_name: Rhonda R.
  full_name: Snook, Rhonda R.
  last_name: Snook
- first_name: Michael G.
  full_name: Ritchie, Michael G.
  last_name: Ritchie
- first_name: Carolin
  full_name: Kosiol, Carolin
  last_name: Kosiol
citation:
  ama: 'de Castro Barbosa Rodrigues Barata C, Snook RR, Ritchie MG, Kosiol C. Selection
    on the fly: Short-term adaptation to an altered sexual selection regime in Drosophila
    pseudoobscura. <i>Genome biology and evolution</i>. 2023;15(7). doi:<a href="https://doi.org/10.1093/gbe/evad113">10.1093/gbe/evad113</a>'
  apa: 'de Castro Barbosa Rodrigues Barata, C., Snook, R. R., Ritchie, M. G., &#38;
    Kosiol, C. (2023). Selection on the fly: Short-term adaptation to an altered sexual
    selection regime in Drosophila pseudoobscura. <i>Genome Biology and Evolution</i>.
    Oxford Academic. <a href="https://doi.org/10.1093/gbe/evad113">https://doi.org/10.1093/gbe/evad113</a>'
  chicago: 'Castro Barbosa Rodrigues Barata, Carolina de, Rhonda R. Snook, Michael
    G. Ritchie, and Carolin Kosiol. “Selection on the Fly: Short-Term Adaptation to
    an Altered Sexual Selection Regime in Drosophila Pseudoobscura.” <i>Genome Biology
    and Evolution</i>. Oxford Academic, 2023. <a href="https://doi.org/10.1093/gbe/evad113">https://doi.org/10.1093/gbe/evad113</a>.'
  ieee: 'C. de Castro Barbosa Rodrigues Barata, R. R. Snook, M. G. Ritchie, and C.
    Kosiol, “Selection on the fly: Short-term adaptation to an altered sexual selection
    regime in Drosophila pseudoobscura,” <i>Genome biology and evolution</i>, vol.
    15, no. 7. Oxford Academic, 2023.'
  ista: 'de Castro Barbosa Rodrigues Barata C, Snook RR, Ritchie MG, Kosiol C. 2023.
    Selection on the fly: Short-term adaptation to an altered sexual selection regime
    in Drosophila pseudoobscura. Genome biology and evolution. 15(7), evad113.'
  mla: 'de Castro Barbosa Rodrigues Barata, Carolina, et al. “Selection on the Fly:
    Short-Term Adaptation to an Altered Sexual Selection Regime in Drosophila Pseudoobscura.”
    <i>Genome Biology and Evolution</i>, vol. 15, no. 7, evad113, Oxford Academic,
    2023, doi:<a href="https://doi.org/10.1093/gbe/evad113">10.1093/gbe/evad113</a>.'
  short: C. de Castro Barbosa Rodrigues Barata, R.R. Snook, M.G. Ritchie, C. Kosiol,
    Genome Biology and Evolution 15 (2023).
date_created: 2023-07-23T22:01:11Z
date_published: 2023-07-01T00:00:00Z
date_updated: 2023-08-02T06:42:35Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/gbe/evad113
external_id:
  isi:
  - '001023444700003'
  pmid:
  - '37341535'
file:
- access_level: open_access
  checksum: 70de3c4878de6efe00dc56de2df8812f
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-01T06:58:34Z
  date_updated: 2023-08-01T06:58:34Z
  file_id: '13339'
  file_name: 2023_GBE_Barata.pdf
  file_size: 2382587
  relation: main_file
  success: 1
file_date_updated: 2023-08-01T06:58:34Z
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genome biology and evolution
publication_identifier:
  eissn:
  - 1759-6653
publication_status: published
publisher: Oxford Academic
quality_controlled: '1'
related_material:
  link:
  - relation: software
    url: https://github.com/carolbarata/dpseudo-n-beyond
scopus_import: '1'
status: public
title: 'Selection on the fly: Short-term adaptation to an altered sexual selection
  regime in Drosophila pseudoobscura'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 15
year: '2023'
...