---
_id: '14887'
abstract:
- lang: eng
  text: 'Episodic memories are encoded by experience-activated neuronal ensembles
    that remain necessary and sufficient for recall. However, the temporal evolution
    of memory engrams after initial encoding is unclear. In this study, we employed
    computational and experimental approaches to examine how the neural composition
    and selectivity of engrams change with memory consolidation. Our spiking neural
    network model yielded testable predictions: memories transition from unselective
    to selective as neurons drop out of and drop into engrams; inhibitory activity
    during recall is essential for memory selectivity; and inhibitory synaptic plasticity
    during memory consolidation is critical for engrams to become selective. Using
    activity-dependent labeling, longitudinal calcium imaging and a combination of
    optogenetic and chemogenetic manipulations in mouse dentate gyrus, we conducted
    contextual fear conditioning experiments that supported our model’s predictions.
    Our results reveal that memory engrams are dynamic and that changes in engram
    composition mediated by inhibitory plasticity are crucial for the emergence of
    memory selectivity.'
acknowledgement: We thank S. Erisken from Inscopix for helping us establish in vivo
  one-photon calcium imaging for this work. We thank K. Su at Tsinghua University
  for assistance with this work. This work was funded by the President’s PhD Scholarship
  from Imperial College London (D.F.T.), the Wellcome Trust (225412/Z/22/Z) (S.S.),
  the Biotechnology and Biological Sciences Research Council (BB/N013956/1 and BB/N019008/1)
  (C.C.), the Wellcome Trust (200790/Z/16/Z) (C.C.), the Simons Foundation (564408)
  (C.C.) and the Engineering and Physical Sciences Research Council (EP/R035806/1)
  (CC). The School of Life Sciences and the IDG/McGovern Institute for Brain Research
  supported Y.Z. The Warren Alpert Distinguished Scholar Award and National Institutes
  of Health 1K99NS125131-01 supported D.S.R.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Douglas
  full_name: Feitosa Tomé, Douglas
  id: 0eed2d40-3d48-11ec-8d38-f789cc2e40b2
  last_name: Feitosa Tomé
- first_name: Ying
  full_name: Zhang, Ying
  last_name: Zhang
- first_name: Tomomi
  full_name: Aida, Tomomi
  last_name: Aida
- first_name: Olivia
  full_name: Mosto, Olivia
  last_name: Mosto
- first_name: Yifeng
  full_name: Lu, Yifeng
  last_name: Lu
- first_name: Mandy
  full_name: Chen, Mandy
  last_name: Chen
- first_name: Sadra
  full_name: Sadeh, Sadra
  last_name: Sadeh
- first_name: Dheeraj S.
  full_name: Roy, Dheeraj S.
  last_name: Roy
- first_name: Claudia
  full_name: Clopath, Claudia
  last_name: Clopath
citation:
  ama: Feitosa Tomé D, Zhang Y, Aida T, et al. Dynamic and selective engrams emerge
    with memory consolidation. <i>Nature Neuroscience</i>. 2024. doi:<a href="https://doi.org/10.1038/s41593-023-01551-w">10.1038/s41593-023-01551-w</a>
  apa: Feitosa Tomé, D., Zhang, Y., Aida, T., Mosto, O., Lu, Y., Chen, M., … Clopath,
    C. (2024). Dynamic and selective engrams emerge with memory consolidation. <i>Nature
    Neuroscience</i>. Springer Nature. <a href="https://doi.org/10.1038/s41593-023-01551-w">https://doi.org/10.1038/s41593-023-01551-w</a>
  chicago: Feitosa Tomé, Douglas, Ying Zhang, Tomomi Aida, Olivia Mosto, Yifeng Lu,
    Mandy Chen, Sadra Sadeh, Dheeraj S. Roy, and Claudia Clopath. “Dynamic and Selective
    Engrams Emerge with Memory Consolidation.” <i>Nature Neuroscience</i>. Springer
    Nature, 2024. <a href="https://doi.org/10.1038/s41593-023-01551-w">https://doi.org/10.1038/s41593-023-01551-w</a>.
  ieee: D. Feitosa Tomé <i>et al.</i>, “Dynamic and selective engrams emerge with
    memory consolidation,” <i>Nature Neuroscience</i>. Springer Nature, 2024.
  ista: Feitosa Tomé D, Zhang Y, Aida T, Mosto O, Lu Y, Chen M, Sadeh S, Roy DS, Clopath
    C. 2024. Dynamic and selective engrams emerge with memory consolidation. Nature
    Neuroscience.
  mla: Feitosa Tomé, Douglas, et al. “Dynamic and Selective Engrams Emerge with Memory
    Consolidation.” <i>Nature Neuroscience</i>, Springer Nature, 2024, doi:<a href="https://doi.org/10.1038/s41593-023-01551-w">10.1038/s41593-023-01551-w</a>.
  short: D. Feitosa Tomé, Y. Zhang, T. Aida, O. Mosto, Y. Lu, M. Chen, S. Sadeh, D.S.
    Roy, C. Clopath, Nature Neuroscience (2024).
date_created: 2024-01-28T23:01:43Z
date_published: 2024-01-19T00:00:00Z
date_updated: 2024-01-29T09:22:00Z
day: '19'
department:
- _id: TiVo
doi: 10.1038/s41593-023-01551-w
external_id:
  isi:
  - '001145442300001'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1038/s41593-023-01551-w
month: '01'
oa: 1
oa_version: Published Version
publication: Nature Neuroscience
publication_identifier:
  eissn:
  - 1546-1726
  issn:
  - 1097-6256
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '14892'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Dynamic and selective engrams emerge with memory consolidation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
_id: '14892'
abstract:
- lang: eng
  text: 'Code and data necessary to reproduce the simulations and data analyses reported
    in our manuscript: Tomé, D.F., Zhang, Y., Aida, T., Mosto, O., Lu, Y., Chen, M.,
    Sadeh, S., Roy, D. S., Clopath, C. Dynamic and selective engrams emerge with memory
    consolidation. 2023.'
article_processing_charge: No
author:
- first_name: Douglas
  full_name: Feitosa Tomé, Douglas
  id: 0eed2d40-3d48-11ec-8d38-f789cc2e40b2
  last_name: Feitosa Tomé
citation:
  ama: 'Feitosa Tomé D. douglastome/dynamic-engrams: Dynamic and selective engrams
    emerge with memory consolidation. 2023. doi:<a href="https://doi.org/10.5281/ZENODO.10251087">10.5281/ZENODO.10251087</a>'
  apa: 'Feitosa Tomé, D. (2023). douglastome/dynamic-engrams: Dynamic and selective
    engrams emerge with memory consolidation. Zenodo. <a href="https://doi.org/10.5281/ZENODO.10251087">https://doi.org/10.5281/ZENODO.10251087</a>'
  chicago: 'Feitosa Tomé, Douglas. “Douglastome/Dynamic-Engrams: Dynamic and Selective
    Engrams Emerge with Memory Consolidation.” Zenodo, 2023. <a href="https://doi.org/10.5281/ZENODO.10251087">https://doi.org/10.5281/ZENODO.10251087</a>.'
  ieee: 'D. Feitosa Tomé, “douglastome/dynamic-engrams: Dynamic and selective engrams
    emerge with memory consolidation.” Zenodo, 2023.'
  ista: 'Feitosa Tomé D. 2023. douglastome/dynamic-engrams: Dynamic and selective
    engrams emerge with memory consolidation, Zenodo, <a href="https://doi.org/10.5281/ZENODO.10251087">10.5281/ZENODO.10251087</a>.'
  mla: 'Feitosa Tomé, Douglas. <i>Douglastome/Dynamic-Engrams: Dynamic and Selective
    Engrams Emerge with Memory Consolidation</i>. Zenodo, 2023, doi:<a href="https://doi.org/10.5281/ZENODO.10251087">10.5281/ZENODO.10251087</a>.'
  short: D. Feitosa Tomé, (2023).
date_created: 2024-01-29T09:06:43Z
date_published: 2023-12-02T00:00:00Z
date_updated: 2024-01-29T09:22:01Z
day: '02'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.5281/ZENODO.10251087
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by/4.0/
main_file_link:
- open_access: '1'
  url: https://doi.org/10.5281/zenodo.10251087
month: '12'
oa: 1
oa_version: None
publisher: Zenodo
related_material:
  record:
  - id: '14887'
    relation: used_in_publication
    status: public
status: public
title: 'douglastome/dynamic-engrams: Dynamic and selective engrams emerge with memory
  consolidation'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...