---
_id: '14613'
abstract:
- lang: eng
  text: 'Many insects carry an ancient X chromosome - the Drosophila Muller element
    F - that likely predates their origin. Interestingly, the X has undergone turnover
    in multiple fly species (Diptera) after being conserved for more than 450 MY.
    The long evolutionary distance between Diptera and other sequenced insect clades
    makes it difficult to infer what could have contributed to this sudden increase
    in rate of turnover. Here, we produce the first genome and transcriptome of a
    long overlooked sister-order to Diptera: Mecoptera. We compare the scorpionfly
    Panorpa cognata X-chromosome gene content, expression, and structure, to that
    of several dipteran species as well as more distantly-related insect orders (Orthoptera
    and Blattodea). We find high conservation of gene content between the mecopteran
    X and the dipteran Muller F element, as well as several shared biological features,
    such as the presence of dosage compensation and a low amount of genetic diversity,
    consistent with a low recombination rate. However, the two homologous X chromosomes
    differ strikingly in their size and number of genes they carry. Our results therefore
    support a common ancestry of the mecopteran and ancestral dipteran X chromosomes,
    and suggest that Muller element F shrank in size and gene content after the split
    of Diptera and Mecoptera, which may have contributed to its turnover in dipteran
    insects.'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "We thank the Vicoso lab for their assistance with specimen collection,
  and Tim Connallon for valuable comments and suggestions on earlier versions of the
  manuscript. Computational resources and support were provided by the Scientific
  Computing unit at the ISTA. This research was supported by grants from the Austrian
  Science Foundation to C.L.\r\n(FWF ESP 39), and to B.V. (FWF SFB F88-10)."
article_number: msad245
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Clementine
  full_name: Lasne, Clementine
  id: 02225f57-50d2-11eb-9ed8-8c92b9a34237
  last_name: Lasne
  orcid: 0000-0002-1197-8616
- first_name: Marwan N
  full_name: Elkrewi, Marwan N
  id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
  last_name: Elkrewi
  orcid: 0000-0002-5328-7231
- first_name: Melissa A
  full_name: Toups, Melissa A
  id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
  last_name: Toups
  orcid: 0000-0002-9752-7380
- first_name: Lorena Alexandra
  full_name: Layana Franco, Lorena Alexandra
  id: 02814589-eb8f-11eb-b029-a70074f3f18f
  last_name: Layana Franco
  orcid: 0000-0002-1253-6297
- first_name: Ariana
  full_name: Macon, Ariana
  id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
  last_name: Macon
- first_name: Beatriz
  full_name: Vicoso, Beatriz
  id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
  last_name: Vicoso
  orcid: 0000-0002-4579-8306
citation:
  ama: Lasne C, Elkrewi MN, Toups MA, Layana Franco LA, Macon A, Vicoso B. The scorpionfly
    (Panorpa cognata) genome highlights conserved and derived features of the peculiar
    dipteran X chromosome. <i>Molecular Biology and Evolution</i>. 2023;40(12). doi:<a
    href="https://doi.org/10.1093/molbev/msad245">10.1093/molbev/msad245</a>
  apa: Lasne, C., Elkrewi, M. N., Toups, M. A., Layana Franco, L. A., Macon, A., &#38;
    Vicoso, B. (2023). The scorpionfly (Panorpa cognata) genome highlights conserved
    and derived features of the peculiar dipteran X chromosome. <i>Molecular Biology
    and Evolution</i>. Oxford University Press. <a href="https://doi.org/10.1093/molbev/msad245">https://doi.org/10.1093/molbev/msad245</a>
  chicago: Lasne, Clementine, Marwan N Elkrewi, Melissa A Toups, Lorena Alexandra
    Layana Franco, Ariana Macon, and Beatriz Vicoso. “The Scorpionfly (Panorpa Cognata)
    Genome Highlights Conserved and Derived Features of the Peculiar Dipteran X Chromosome.”
    <i>Molecular Biology and Evolution</i>. Oxford University Press, 2023. <a href="https://doi.org/10.1093/molbev/msad245">https://doi.org/10.1093/molbev/msad245</a>.
  ieee: C. Lasne, M. N. Elkrewi, M. A. Toups, L. A. Layana Franco, A. Macon, and B.
    Vicoso, “The scorpionfly (Panorpa cognata) genome highlights conserved and derived
    features of the peculiar dipteran X chromosome,” <i>Molecular Biology and Evolution</i>,
    vol. 40, no. 12. Oxford University Press, 2023.
  ista: Lasne C, Elkrewi MN, Toups MA, Layana Franco LA, Macon A, Vicoso B. 2023.
    The scorpionfly (Panorpa cognata) genome highlights conserved and derived features
    of the peculiar dipteran X chromosome. Molecular Biology and Evolution. 40(12),
    msad245.
  mla: Lasne, Clementine, et al. “The Scorpionfly (Panorpa Cognata) Genome Highlights
    Conserved and Derived Features of the Peculiar Dipteran X Chromosome.” <i>Molecular
    Biology and Evolution</i>, vol. 40, no. 12, msad245, Oxford University Press,
    2023, doi:<a href="https://doi.org/10.1093/molbev/msad245">10.1093/molbev/msad245</a>.
  short: C. Lasne, M.N. Elkrewi, M.A. Toups, L.A. Layana Franco, A. Macon, B. Vicoso,
    Molecular Biology and Evolution 40 (2023).
date_created: 2023-11-27T16:14:37Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2024-02-21T12:18:35Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/molbev/msad245
external_id:
  pmid:
  - '37988296'
file:
- access_level: open_access
  checksum: 47c1c72fb499f26ea52d216b242208c8
  content_type: application/pdf
  creator: dernst
  date_created: 2024-01-02T11:39:38Z
  date_updated: 2024-01-02T11:39:38Z
  file_id: '14727'
  file_name: 2023_MolecularBioEvo_Lasne.pdf
  file_size: 8623505
  relation: main_file
  success: 1
file_date_updated: 2024-01-02T11:39:38Z
has_accepted_license: '1'
intvolume: '        40'
issue: '12'
keyword:
- Genetics
- Molecular Biology
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 34ae1506-11ca-11ed-8bc3-c14f4c474396
  grant_number: F8810
  name: The highjacking of meiosis for asexual reproduction
- _id: ebb230e0-77a9-11ec-83b8-87a37e0241d3
  grant_number: ESP39 49461
  name: Mechanisms and Evolution of Reproductive Plasticity
publication: Molecular Biology and Evolution
publication_identifier:
  eissn:
  - 1537-1719
  issn:
  - 0737-4038
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA webpage
    relation: press_release
    url: https://ista.ac.at/en/news/on-the-hunt/
  record:
  - id: '14614'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: The scorpionfly (Panorpa cognata) genome highlights conserved and derived features
  of the peculiar dipteran X chromosome
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 40
year: '2023'
...