---
_id: '11812'
abstract:
- lang: eng
  text: "This paper presents a comprehensive study of algorithms for maintaining the
    number of all connected four-vertex subgraphs in a dynamic graph. Specifically,
    our algorithms maintain the number of paths of length three in deterministic amortized
    O(m^{1/2}) update time, and any other connected four-vertex subgraph which is
    not a clique in deterministic amortized update time O(m^{2/3}). Queries can be
    answered in constant time. We also study the query times for subgraphs containing
    an arbitrary edge that is supplied only with the query as well as the case where
    only subgraphs containing a vertex s that is fixed beforehand are considered.
    For length-3 paths, paws, 4-cycles, and diamonds our bounds match or are not far
    from (conditional) lower bounds: Based on the OMv conjecture we show that any
    dynamic algorithm that detects the existence of paws, diamonds, or 4-cycles or
    that counts length-3 paths takes update time Ω(m^{1/2-δ}).\r\nAdditionally, for
    4-cliques and all connected induced subgraphs, we show a lower bound of Ω(m^{1-δ})
    for any small constant δ > 0 for the amortized update time, assuming the static
    combinatorial 4-clique conjecture holds. This shows that the O(m) algorithm by
    Eppstein et al. [David Eppstein et al., 2012] for these subgraphs cannot be improved
    by a polynomial factor."
alternative_title:
- LIPIcs
article_number: '18'
article_processing_charge: No
arxiv: 1
author:
- first_name: Kathrin
  full_name: Hanauer, Kathrin
  last_name: Hanauer
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Qi Cheng
  full_name: Hua, Qi Cheng
  last_name: Hua
citation:
  ama: 'Hanauer K, Henzinger MH, Hua QC. Fully dynamic four-vertex subgraph counting.
    In: <i>1st Symposium on Algorithmic Foundations of Dynamic Networks</i>. Vol 221.
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2022. doi:<a href="https://doi.org/10.4230/LIPIcs.SAND.2022.18">10.4230/LIPIcs.SAND.2022.18</a>'
  apa: 'Hanauer, K., Henzinger, M. H., &#38; Hua, Q. C. (2022). Fully dynamic four-vertex
    subgraph counting. In <i>1st Symposium on Algorithmic Foundations of Dynamic Networks</i>
    (Vol. 221). Virtual: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href="https://doi.org/10.4230/LIPIcs.SAND.2022.18">https://doi.org/10.4230/LIPIcs.SAND.2022.18</a>'
  chicago: Hanauer, Kathrin, Monika H Henzinger, and Qi Cheng Hua. “Fully Dynamic
    Four-Vertex Subgraph Counting.” In <i>1st Symposium on Algorithmic Foundations
    of Dynamic Networks</i>, Vol. 221. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
    2022. <a href="https://doi.org/10.4230/LIPIcs.SAND.2022.18">https://doi.org/10.4230/LIPIcs.SAND.2022.18</a>.
  ieee: K. Hanauer, M. H. Henzinger, and Q. C. Hua, “Fully dynamic four-vertex subgraph
    counting,” in <i>1st Symposium on Algorithmic Foundations of Dynamic Networks</i>,
    Virtual, 2022, vol. 221.
  ista: 'Hanauer K, Henzinger MH, Hua QC. 2022. Fully dynamic four-vertex subgraph
    counting. 1st Symposium on Algorithmic Foundations of Dynamic Networks. SAND:
    Symposium on Algorithmic Foundations of Dynamic Networks, LIPIcs, vol. 221, 18.'
  mla: Hanauer, Kathrin, et al. “Fully Dynamic Four-Vertex Subgraph Counting.” <i>1st
    Symposium on Algorithmic Foundations of Dynamic Networks</i>, vol. 221, 18, Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik, 2022, doi:<a href="https://doi.org/10.4230/LIPIcs.SAND.2022.18">10.4230/LIPIcs.SAND.2022.18</a>.
  short: K. Hanauer, M.H. Henzinger, Q.C. Hua, in:, 1st Symposium on Algorithmic Foundations
    of Dynamic Networks, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2022.
conference:
  end_date: 2022-04-30
  location: Virtual
  name: 'SAND: Symposium on Algorithmic Foundations of Dynamic Networks'
  start_date: 2022-04-28
date_created: 2022-08-12T06:57:55Z
date_published: 2022-04-29T00:00:00Z
date_updated: 2023-02-14T08:25:42Z
day: '29'
doi: 10.4230/LIPIcs.SAND.2022.18
extern: '1'
external_id:
  arxiv:
  - '2106.15524'
intvolume: '       221'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.4230/LIPIcs.SAND.2022.18
month: '04'
oa: 1
oa_version: Published Version
publication: 1st Symposium on Algorithmic Foundations of Dynamic Networks
publication_identifier:
  isbn:
  - '9783959772242'
  issn:
  - 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fully dynamic four-vertex subgraph counting
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 221
year: '2022'
...
---
_id: '11839'
abstract:
- lang: eng
  text: "It is a highly desirable property for deep networks to be robust against\r\nsmall
    input changes. One popular way to achieve this property is by designing\r\nnetworks
    with a small Lipschitz constant. In this work, we propose a new\r\ntechnique for
    constructing such Lipschitz networks that has a number of\r\ndesirable properties:
    it can be applied to any linear network layer\r\n(fully-connected or convolutional),
    it provides formal guarantees on the\r\nLipschitz constant, it is easy to implement
    and efficient to run, and it can be\r\ncombined with any training objective and
    optimization method. In fact, our\r\ntechnique is the first one in the literature
    that achieves all of these\r\nproperties simultaneously. Our main contribution
    is a rescaling-based weight\r\nmatrix parametrization that guarantees each network
    layer to have a Lipschitz\r\nconstant of at most 1 and results in the learned
    weight matrices to be close to\r\northogonal. Hence we call such layers almost-orthogonal
    Lipschitz (AOL).\r\nExperiments and ablation studies in the context of image classification
    with\r\ncertified robust accuracy confirm that AOL layers achieve results that
    are on\r\npar with most existing methods. Yet, they are simpler to implement and
    more\r\nbroadly applicable, because they do not require computationally expensive\r\nmatrix
    orthogonalization or inversion steps as part of the network\r\narchitecture. We
    provide code at https://github.com/berndprach/AOL."
alternative_title:
- LNCS
article_processing_charge: No
arxiv: 1
author:
- first_name: Bernd
  full_name: Prach, Bernd
  id: 2D561D42-C427-11E9-89B4-9C1AE6697425
  last_name: Prach
- first_name: Christoph
  full_name: Lampert, Christoph
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: 'Prach B, Lampert C. Almost-orthogonal layers for efficient general-purpose
    Lipschitz networks. In: <i>Computer Vision – ECCV 2022</i>. Vol 13681. Springer
    Nature; 2022:350-365. doi:<a href="https://doi.org/10.1007/978-3-031-19803-8_21">10.1007/978-3-031-19803-8_21</a>'
  apa: 'Prach, B., &#38; Lampert, C. (2022). Almost-orthogonal layers for efficient
    general-purpose Lipschitz networks. In <i>Computer Vision – ECCV 2022</i> (Vol.
    13681, pp. 350–365). Tel Aviv, Israel: Springer Nature. <a href="https://doi.org/10.1007/978-3-031-19803-8_21">https://doi.org/10.1007/978-3-031-19803-8_21</a>'
  chicago: Prach, Bernd, and Christoph Lampert. “Almost-Orthogonal Layers for Efficient
    General-Purpose Lipschitz Networks.” In <i>Computer Vision – ECCV 2022</i>, 13681:350–65.
    Springer Nature, 2022. <a href="https://doi.org/10.1007/978-3-031-19803-8_21">https://doi.org/10.1007/978-3-031-19803-8_21</a>.
  ieee: B. Prach and C. Lampert, “Almost-orthogonal layers for efficient general-purpose
    Lipschitz networks,” in <i>Computer Vision – ECCV 2022</i>, Tel Aviv, Israel,
    2022, vol. 13681, pp. 350–365.
  ista: 'Prach B, Lampert C. 2022. Almost-orthogonal layers for efficient general-purpose
    Lipschitz networks. Computer Vision – ECCV 2022. ECCV: European Conference on
    Computer Vision, LNCS, vol. 13681, 350–365.'
  mla: Prach, Bernd, and Christoph Lampert. “Almost-Orthogonal Layers for Efficient
    General-Purpose Lipschitz Networks.” <i>Computer Vision – ECCV 2022</i>, vol.
    13681, Springer Nature, 2022, pp. 350–65, doi:<a href="https://doi.org/10.1007/978-3-031-19803-8_21">10.1007/978-3-031-19803-8_21</a>.
  short: B. Prach, C. Lampert, in:, Computer Vision – ECCV 2022, Springer Nature,
    2022, pp. 350–365.
conference:
  end_date: 2022-10-27
  location: Tel Aviv, Israel
  name: 'ECCV: European Conference on Computer Vision'
  start_date: 2022-10-23
date_created: 2022-08-12T15:09:47Z
date_published: 2022-10-23T00:00:00Z
date_updated: 2023-05-03T08:00:46Z
day: '23'
department:
- _id: GradSch
- _id: ChLa
doi: 10.1007/978-3-031-19803-8_21
external_id:
  arxiv:
  - '2208.03160'
intvolume: '     13681'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: ' https://doi.org/10.48550/arXiv.2208.03160'
month: '10'
oa: 1
oa_version: Preprint
page: 350-365
publication: Computer Vision – ECCV 2022
publication_identifier:
  eisbn:
  - '9783031198038'
  isbn:
  - '9783031198021'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Almost-orthogonal layers for efficient general-purpose Lipschitz networks
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13681
year: '2022'
...
---
_id: '11841'
abstract:
- lang: eng
  text: Primary nucleation is the fundamental event that initiates the conversion
    of proteins from their normal physiological forms into pathological amyloid aggregates
    associated with the onset and development of disorders including systemic amyloidosis,
    as well as the neurodegenerative conditions Alzheimer’s and Parkinson’s diseases.
    It has become apparent that the presence of surfaces can dramatically modulate
    nucleation. However, the underlying physicochemical parameters governing this
    process have been challenging to elucidate, with interfaces in some cases having
    been found to accelerate aggregation, while in others they can inhibit the kinetics
    of this process. Here we show through kinetic analysis that for three different
    fibril-forming proteins, interfaces affect the aggregation reaction mainly through
    modulating the primary nucleation step. Moreover, we show through direct measurements
    of the Gibbs free energy of adsorption, combined with theory and coarse-grained
    computer simulations, that overall nucleation rates are suppressed at high and
    at low surface interaction strengths but significantly enhanced at intermediate
    strengths, and we verify these regimes experimentally. Taken together, these results
    provide a quantitative description of the fundamental process which triggers amyloid
    formation and shed light on the key factors that control this process.
acknowledgement: "The research leading to these results has received funding from
  the European Research Council (ERC) under the European Union’s Seventh Framework
  Programme (FP7/2007-2013) through the ERC grant PhysProt\r\n(agreement 337969).
  We are grateful for financial support from the Biotechnology and Biological Sciences
  Research Council (BBSRC) (T.P.J.K.), the Newman\r\nFoundation (T.P.J.K.), the Wellcome
  Trust (T.P.J.K. and M.V.), Peterhouse College\r\nCambridge (T.C.T.M.), the ERC Starting
  Grant (StG) Non-Equilibrium Protein Assembly (NEPA) (A.S.), the Royal Society (A.S.),
  the Academy of Medical Sciences\r\n(A.S. and J.K.), and the Cambridge Centre for
  Misfolding Diseases (CMD)."
article_number: e2109718119
article_processing_charge: No
article_type: original
author:
- first_name: Zenon
  full_name: Toprakcioglu, Zenon
  last_name: Toprakcioglu
- first_name: Ayaka
  full_name: Kamada, Ayaka
  last_name: Kamada
- first_name: Thomas C.T.
  full_name: Michaels, Thomas C.T.
  last_name: Michaels
- first_name: Mengqi
  full_name: Xie, Mengqi
  last_name: Xie
- first_name: Johannes
  full_name: Krausser, Johannes
  last_name: Krausser
- first_name: Jiapeng
  full_name: Wei, Jiapeng
  last_name: Wei
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: Michele
  full_name: Vendruscolo, Michele
  last_name: Vendruscolo
- first_name: Tuomas P.J.
  full_name: Knowles, Tuomas P.J.
  last_name: Knowles
citation:
  ama: Toprakcioglu Z, Kamada A, Michaels TCT, et al. Adsorption free energy predicts
    amyloid protein nucleation rates. <i>Proceedings of the National Academy of Sciences
    of the United States of America</i>. 2022;119(31). doi:<a href="https://doi.org/10.1073/pnas.2109718119">10.1073/pnas.2109718119</a>
  apa: Toprakcioglu, Z., Kamada, A., Michaels, T. C. T., Xie, M., Krausser, J., Wei,
    J., … Knowles, T. P. J. (2022). Adsorption free energy predicts amyloid protein
    nucleation rates. <i>Proceedings of the National Academy of Sciences of the United
    States of America</i>. Proceedings of the National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.2109718119">https://doi.org/10.1073/pnas.2109718119</a>
  chicago: Toprakcioglu, Zenon, Ayaka Kamada, Thomas C.T. Michaels, Mengqi Xie, Johannes
    Krausser, Jiapeng Wei, Anđela Šarić, Michele Vendruscolo, and Tuomas P.J. Knowles.
    “Adsorption Free Energy Predicts Amyloid Protein Nucleation Rates.” <i>Proceedings
    of the National Academy of Sciences of the United States of America</i>. Proceedings
    of the National Academy of Sciences, 2022. <a href="https://doi.org/10.1073/pnas.2109718119">https://doi.org/10.1073/pnas.2109718119</a>.
  ieee: Z. Toprakcioglu <i>et al.</i>, “Adsorption free energy predicts amyloid protein
    nucleation rates,” <i>Proceedings of the National Academy of Sciences of the United
    States of America</i>, vol. 119, no. 31. Proceedings of the National Academy of
    Sciences, 2022.
  ista: Toprakcioglu Z, Kamada A, Michaels TCT, Xie M, Krausser J, Wei J, Šarić A,
    Vendruscolo M, Knowles TPJ. 2022. Adsorption free energy predicts amyloid protein
    nucleation rates. Proceedings of the National Academy of Sciences of the United
    States of America. 119(31), e2109718119.
  mla: Toprakcioglu, Zenon, et al. “Adsorption Free Energy Predicts Amyloid Protein
    Nucleation Rates.” <i>Proceedings of the National Academy of Sciences of the United
    States of America</i>, vol. 119, no. 31, e2109718119, Proceedings of the National
    Academy of Sciences, 2022, doi:<a href="https://doi.org/10.1073/pnas.2109718119">10.1073/pnas.2109718119</a>.
  short: Z. Toprakcioglu, A. Kamada, T.C.T. Michaels, M. Xie, J. Krausser, J. Wei,
    A. Šarić, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National Academy
    of Sciences of the United States of America 119 (2022).
date_created: 2022-08-14T22:01:45Z
date_published: 2022-07-28T00:00:00Z
date_updated: 2023-10-04T09:06:52Z
day: '28'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1073/pnas.2109718119
ec_funded: 1
external_id:
  isi:
  - '000903753500002'
file:
- access_level: open_access
  checksum: 0fe3878896cbeb6c44e29222ec2f336a
  content_type: application/pdf
  creator: dernst
  date_created: 2023-10-04T09:05:44Z
  date_updated: 2023-10-04T09:05:44Z
  file_id: '14386'
  file_name: 2022_PNAS_Toprakcioglu.pdf
  file_size: 2476021
  relation: main_file
  success: 1
file_date_updated: 2023-10-04T09:05:44Z
has_accepted_license: '1'
intvolume: '       119'
isi: 1
issue: '31'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
  call_identifier: H2020
  grant_number: '802960'
  name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Proceedings of the National Academy of Sciences of the United States
  of America
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: Proceedings of the National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adsorption free energy predicts amyloid protein nucleation rates
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 119
year: '2022'
...
---
_id: '11842'
abstract:
- lang: eng
  text: We consider the flow of two viscous and incompressible fluids within a bounded
    domain modeled by means of a two-phase Navier–Stokes system. The two fluids are
    assumed to be immiscible, meaning that they are separated by an interface. With
    respect to the motion of the interface, we consider pure transport by the fluid
    flow. Along the boundary of the domain, a complete slip boundary condition for
    the fluid velocities and a constant ninety degree contact angle condition for
    the interface are assumed. In the present work, we devise for the resulting evolution
    problem a suitable weak solution concept based on the framework of varifolds and
    establish as the main result a weak-strong uniqueness principle in 2D. The proof
    is based on a relative entropy argument and requires a non-trivial further development
    of ideas from the recent work of Fischer and the first author (Arch. Ration. Mech.
    Anal. 236, 2020) to incorporate the contact angle condition. To focus on the effects
    of the necessarily singular geometry of the evolving fluid domains, we work for
    simplicity in the regime of same viscosities for the two fluids.
acknowledgement: The authors warmly thank their former resp. current PhD advisor Julian
  Fischer for the suggestion of this problem and for valuable initial discussions
  on the subjects of this paper. This project has received funding from the European
  Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
  programme (grant agreement No 948819) , and from the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2047/1
  – 390685813.
article_number: '93'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Sebastian
  full_name: Hensel, Sebastian
  id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87
  last_name: Hensel
  orcid: 0000-0001-7252-8072
- first_name: Alice
  full_name: Marveggio, Alice
  id: 25647992-AA84-11E9-9D75-8427E6697425
  last_name: Marveggio
citation:
  ama: Hensel S, Marveggio A. Weak-strong uniqueness for the Navier–Stokes equation
    for two fluids with ninety degree contact angle and same viscosities. <i>Journal
    of Mathematical Fluid Mechanics</i>. 2022;24(3). doi:<a href="https://doi.org/10.1007/s00021-022-00722-2">10.1007/s00021-022-00722-2</a>
  apa: Hensel, S., &#38; Marveggio, A. (2022). Weak-strong uniqueness for the Navier–Stokes
    equation for two fluids with ninety degree contact angle and same viscosities.
    <i>Journal of Mathematical Fluid Mechanics</i>. Springer Nature. <a href="https://doi.org/10.1007/s00021-022-00722-2">https://doi.org/10.1007/s00021-022-00722-2</a>
  chicago: Hensel, Sebastian, and Alice Marveggio. “Weak-Strong Uniqueness for the
    Navier–Stokes Equation for Two Fluids with Ninety Degree Contact Angle and Same
    Viscosities.” <i>Journal of Mathematical Fluid Mechanics</i>. Springer Nature,
    2022. <a href="https://doi.org/10.1007/s00021-022-00722-2">https://doi.org/10.1007/s00021-022-00722-2</a>.
  ieee: S. Hensel and A. Marveggio, “Weak-strong uniqueness for the Navier–Stokes
    equation for two fluids with ninety degree contact angle and same viscosities,”
    <i>Journal of Mathematical Fluid Mechanics</i>, vol. 24, no. 3. Springer Nature,
    2022.
  ista: Hensel S, Marveggio A. 2022. Weak-strong uniqueness for the Navier–Stokes
    equation for two fluids with ninety degree contact angle and same viscosities.
    Journal of Mathematical Fluid Mechanics. 24(3), 93.
  mla: Hensel, Sebastian, and Alice Marveggio. “Weak-Strong Uniqueness for the Navier–Stokes
    Equation for Two Fluids with Ninety Degree Contact Angle and Same Viscosities.”
    <i>Journal of Mathematical Fluid Mechanics</i>, vol. 24, no. 3, 93, Springer Nature,
    2022, doi:<a href="https://doi.org/10.1007/s00021-022-00722-2">10.1007/s00021-022-00722-2</a>.
  short: S. Hensel, A. Marveggio, Journal of Mathematical Fluid Mechanics 24 (2022).
date_created: 2022-08-14T22:01:45Z
date_published: 2022-08-01T00:00:00Z
date_updated: 2023-11-30T13:25:02Z
day: '01'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1007/s00021-022-00722-2
ec_funded: 1
external_id:
  arxiv:
  - '2112.11154'
  isi:
  - '000834834300001'
file:
- access_level: open_access
  checksum: 75c5f286300e6f0539cf57b4dba108d5
  content_type: application/pdf
  creator: cchlebak
  date_created: 2022-08-16T06:55:22Z
  date_updated: 2022-08-16T06:55:22Z
  file_id: '11848'
  file_name: 2022_JMathFluidMech_Hensel.pdf
  file_size: 2045570
  relation: main_file
  success: 1
file_date_updated: 2022-08-16T06:55:22Z
has_accepted_license: '1'
intvolume: '        24'
isi: 1
issue: '3'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
  call_identifier: H2020
  grant_number: '948819'
  name: Bridging Scales in Random Materials
publication: Journal of Mathematical Fluid Mechanics
publication_identifier:
  eissn:
  - 1422-6952
  issn:
  - 1422-6928
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '14587'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Weak-strong uniqueness for the Navier–Stokes equation for two fluids with ninety
  degree contact angle and same viscosities
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 24
year: '2022'
...
---
_id: '11843'
abstract:
- lang: eng
  text: A key attribute of persistent or recurring bacterial infections is the ability
    of the pathogen to evade the host’s immune response. Many Enterobacteriaceae express
    type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and
    establish persistent infections. However, the molecular mechanisms and strategies
    by which bacteria actively circumvent the immune response of the host remain poorly
    understood. Here, we identified CD14, the major co-receptor for lipopolysaccharide
    detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein
    located at the tip of the type 1 pilus of Escherichia coli. The FimH amino acids
    involved in CD14 binding are highly conserved across pathogenic and non-pathogenic
    strains. Binding of the pathogenic strain CFT073 to CD14 reduced DC migration
    by overactivation of integrins and blunted expression of co-stimulatory molecules
    by overactivating the NFAT (nuclear factor of activated T-cells) pathway, both
    rate-limiting factors of T cell activation. This response was binary at the single-cell
    level, but averaged in larger populations exposed to both piliated and non-piliated
    pathogens, presumably via the exchange of immunomodulatory cytokines. While defining
    an active molecular mechanism of immune evasion by pathogens, the interaction
    between FimH and CD14 represents a potential target to interfere with persistent
    and recurrent infections, such as urinary tract infections or Crohn’s disease.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: EM-Fac
acknowledgement: We thank Ulrich Dobrindt for providing UPEC strains CFT073, UTI89,
  and 536, Frank Assen, Vlad Gavra, Maximilian Götz, Bor Kavčič, Jonna Alanko, and
  Eva Kiermaier for help with experiments and Robert Hauschild, Julian Stopp, and
  Saren Tasciyan for help with data analysis. We thank the IST Austria Scientific
  Service Units, especially the Bioimaging facility, the Preclinical facility and
  the Electron microscopy facility for technical support, Jakob Wallner and all members
  of the Guet and Sixt lab for fruitful discussions and Daria Siekhaus for critically
  reading the manuscript. This work was supported by grants from the Austrian Research
  Promotion Agency (FEMtech 868984) to IG, the European Research Council (CoG 724373),
  and the Austrian Science Fund (FWF P29911) to MS.
article_number: e78995
article_processing_charge: Yes
article_type: original
author:
- first_name: Kathrin
  full_name: Tomasek, Kathrin
  id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
  last_name: Tomasek
- first_name: Alexander F
  full_name: Leithner, Alexander F
  id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
  last_name: Leithner
- first_name: Ivana
  full_name: Glatzová, Ivana
  id: 727b3c7d-4939-11ec-89b3-b9b0750ab74d
  last_name: Glatzová
- first_name: Michael S.
  full_name: Lukesch, Michael S.
  last_name: Lukesch
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. Type 1 piliated
    uropathogenic Escherichia coli hijack the host immune response by binding to CD14.
    <i>eLife</i>. 2022;11. doi:<a href="https://doi.org/10.7554/eLife.78995">10.7554/eLife.78995</a>
  apa: Tomasek, K., Leithner, A. F., Glatzová, I., Lukesch, M. S., Guet, C. C., &#38;
    Sixt, M. K. (2022). Type 1 piliated uropathogenic Escherichia coli hijack the
    host immune response by binding to CD14. <i>ELife</i>. eLife Sciences Publications.
    <a href="https://doi.org/10.7554/eLife.78995">https://doi.org/10.7554/eLife.78995</a>
  chicago: Tomasek, Kathrin, Alexander F Leithner, Ivana Glatzová, Michael S. Lukesch,
    Calin C Guet, and Michael K Sixt. “Type 1 Piliated Uropathogenic Escherichia Coli
    Hijack the Host Immune Response by Binding to CD14.” <i>ELife</i>. eLife Sciences
    Publications, 2022. <a href="https://doi.org/10.7554/eLife.78995">https://doi.org/10.7554/eLife.78995</a>.
  ieee: K. Tomasek, A. F. Leithner, I. Glatzová, M. S. Lukesch, C. C. Guet, and M.
    K. Sixt, “Type 1 piliated uropathogenic Escherichia coli hijack the host immune
    response by binding to CD14,” <i>eLife</i>, vol. 11. eLife Sciences Publications,
    2022.
  ista: Tomasek K, Leithner AF, Glatzová I, Lukesch MS, Guet CC, Sixt MK. 2022. Type
    1 piliated uropathogenic Escherichia coli hijack the host immune response by binding
    to CD14. eLife. 11, e78995.
  mla: Tomasek, Kathrin, et al. “Type 1 Piliated Uropathogenic Escherichia Coli Hijack
    the Host Immune Response by Binding to CD14.” <i>ELife</i>, vol. 11, e78995, eLife
    Sciences Publications, 2022, doi:<a href="https://doi.org/10.7554/eLife.78995">10.7554/eLife.78995</a>.
  short: K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt,
    ELife 11 (2022).
date_created: 2022-08-14T22:01:46Z
date_published: 2022-07-26T00:00:00Z
date_updated: 2023-08-03T12:54:21Z
day: '26'
ddc:
- '570'
department:
- _id: MiSi
- _id: CaGu
doi: 10.7554/eLife.78995
ec_funded: 1
external_id:
  isi:
  - '000838410200001'
file:
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  date_created: 2022-08-16T08:57:37Z
  date_updated: 2022-08-16T08:57:37Z
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isi: 1
language:
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month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25FE9508-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '724373'
  name: Cellular navigation along spatial gradients
- _id: 26018E70-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P29911
  name: Mechanical adaptation of lamellipodial actin
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
related_material:
  record:
  - id: '10316'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Type 1 piliated uropathogenic Escherichia coli hijack the host immune response
  by binding to CD14
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2022'
...
---
_id: '11844'
abstract:
- lang: eng
  text: "In the stochastic population protocol model, we are given a connected graph
    with n nodes, and in every time step, a scheduler samples an edge of the graph
    uniformly at random and the nodes connected by this edge interact. A fundamental
    task in this model is stable leader election, in which all nodes start in an identical
    state and the aim is to reach a configuration in which (1) exactly one node is
    elected as leader and (2) this node remains as the unique leader no matter what
    sequence of interactions follows. On cliques, the complexity of this problem has
    recently been settled: time-optimal protocols stabilize in Θ(n log n) expected
    steps using Θ(log log n) states, whereas protocols that use O(1) states require
    Θ(n2) expected steps.\r\n\r\nIn this work, we investigate the complexity of stable
    leader election on general graphs. We provide the first non-trivial time lower
    bounds for leader election on general graphs, showing that, when moving beyond
    cliques, the complexity landscape of leader election becomes very diverse: the
    time required to elect a leader can range from O(1) to Θ(n3) expected steps. On
    the upper bound side, we first observe that there exists a protocol that is time-optimal
    on many graph families, but uses polynomially-many states. In contrast, we give
    a near-time-optimal protocol that uses only O(log2n) states that is at most a
    factor log n slower. Finally, we show that the constant-state protocol of Beauquier
    et al. [OPODIS 2013] is at most a factor n log n slower than the fast polynomial-state
    protocol. Moreover, among constant-state protocols, this protocol has near-optimal
    average case complexity on dense random graphs."
acknowledgement: We thank the anonymous reviewers for their helpful comments. We gratefully
  acknowledge funding from the European Research Council (ERC) under the European
  Union’s Horizon 2020 research and innovation programme (grant agreement No 805223
  ScaleML).
article_processing_charge: Yes (via OA deal)
arxiv: 1
author:
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: Joel
  full_name: Rybicki, Joel
  id: 334EFD2E-F248-11E8-B48F-1D18A9856A87
  last_name: Rybicki
  orcid: 0000-0002-6432-6646
- first_name: Sasha
  full_name: Voitovych, Sasha
  last_name: Voitovych
citation:
  ama: 'Alistarh D-A, Rybicki J, Voitovych S. Near-optimal leader election in population
    protocols on graphs. In: <i>Proceedings of the Annual ACM Symposium on Principles
    of Distributed Computing</i>. Association for Computing Machinery; 2022:246-256.
    doi:<a href="https://doi.org/10.1145/3519270.3538435">10.1145/3519270.3538435</a>'
  apa: 'Alistarh, D.-A., Rybicki, J., &#38; Voitovych, S. (2022). Near-optimal leader
    election in population protocols on graphs. In <i>Proceedings of the Annual ACM
    Symposium on Principles of Distributed Computing</i> (pp. 246–256). Salerno, Italy:
    Association for Computing Machinery. <a href="https://doi.org/10.1145/3519270.3538435">https://doi.org/10.1145/3519270.3538435</a>'
  chicago: Alistarh, Dan-Adrian, Joel Rybicki, and Sasha Voitovych. “Near-Optimal
    Leader Election in Population Protocols on Graphs.” In <i>Proceedings of the Annual
    ACM Symposium on Principles of Distributed Computing</i>, 246–56. Association
    for Computing Machinery, 2022. <a href="https://doi.org/10.1145/3519270.3538435">https://doi.org/10.1145/3519270.3538435</a>.
  ieee: D.-A. Alistarh, J. Rybicki, and S. Voitovych, “Near-optimal leader election
    in population protocols on graphs,” in <i>Proceedings of the Annual ACM Symposium
    on Principles of Distributed Computing</i>, Salerno, Italy, 2022, pp. 246–256.
  ista: 'Alistarh D-A, Rybicki J, Voitovych S. 2022. Near-optimal leader election
    in population protocols on graphs. Proceedings of the Annual ACM Symposium on
    Principles of Distributed Computing. PODC: Symposium on Principles of Distributed
    Computing, 246–256.'
  mla: Alistarh, Dan-Adrian, et al. “Near-Optimal Leader Election in Population Protocols
    on Graphs.” <i>Proceedings of the Annual ACM Symposium on Principles of Distributed
    Computing</i>, Association for Computing Machinery, 2022, pp. 246–56, doi:<a href="https://doi.org/10.1145/3519270.3538435">10.1145/3519270.3538435</a>.
  short: D.-A. Alistarh, J. Rybicki, S. Voitovych, in:, Proceedings of the Annual
    ACM Symposium on Principles of Distributed Computing, Association for Computing
    Machinery, 2022, pp. 246–256.
conference:
  end_date: 2022-07-29
  location: Salerno, Italy
  name: 'PODC: Symposium on Principles of Distributed Computing'
  start_date: 2022-07-25
date_created: 2022-08-14T22:01:46Z
date_published: 2022-07-21T00:00:00Z
date_updated: 2023-06-14T12:06:01Z
day: '21'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.1145/3519270.3538435
ec_funded: 1
external_id:
  arxiv:
  - '2205.12597'
file:
- access_level: open_access
  checksum: 4c6b29172b8e355b4fbc364a2e0827b2
  content_type: application/pdf
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  date_created: 2022-08-16T08:05:15Z
  date_updated: 2022-08-16T08:05:15Z
  file_id: '11854'
  file_name: 2022_PODC_Alistarh.pdf
  file_size: 1593474
  relation: main_file
  success: 1
file_date_updated: 2022-08-16T08:05:15Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 246-256
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '805223'
  name: Elastic Coordination for Scalable Machine Learning
publication: Proceedings of the Annual ACM Symposium on Principles of Distributed
  Computing
publication_identifier:
  isbn:
  - '9781450392624'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Near-optimal leader election in population protocols on graphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11858'
abstract:
- lang: eng
  text: "This paper is a continuation of Part I of this project, where we developed
    a new local well-posedness theory for nonlinear stochastic PDEs with Gaussian
    noise. In the current Part II we consider blow-up criteria and regularization
    phenomena. As in Part I we can allow nonlinearities with polynomial growth and
    rough initial values from critical spaces. In the first main result we obtain
    several new blow-up criteria for quasi- and semilinear stochastic evolution equations.
    In particular, for semilinear equations we obtain a Serrin type blow-up criterium,
    which extends a recent result of Prüss–Simonett–Wilke (J Differ Equ 264(3):2028–2074,
    2018) to the stochastic setting. Blow-up criteria can be used to prove global
    well-posedness for SPDEs. As in Part I, maximal regularity techniques and weights
    in time play a central role in the proofs. Our second contribution is a new method
    to bootstrap Sobolev and Hölder regularity in time and space, which does not require
    smoothness of the initial data. The blow-up criteria are at the basis of these
    new methods. Moreover, in applications the bootstrap results can be combined with
    our blow-up criteria, to obtain efficient ways to prove global existence. This
    gives new results even in classical \U0001D43F2-settings, which we illustrate
    for a concrete SPDE. In future works in preparation we apply the results of the
    current paper to obtain global well-posedness results and regularity for several
    concrete SPDEs. These include stochastic Navier–Stokes equations, reaction– diffusion
    equations and the Allen–Cahn equation. Our setting allows to put these SPDEs into
    a more flexible framework, where less restrictions on the nonlinearities are needed,
    and we are able to treat rough initial values from critical spaces. Moreover,
    we will obtain higher-order regularity results."
acknowledgement: "The authors thank Emiel Lorist for helpful comments. The authors
  thank the anonymous referees for their helpful remarks to improve the presentation.\r\nOpen
  access funding provided by Institute of Science and Technology (IST Austria)."
article_number: '56'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Antonio
  full_name: Agresti, Antonio
  id: 673cd0cc-9b9a-11eb-b144-88f30e1fbb72
  last_name: Agresti
  orcid: 0000-0002-9573-2962
- first_name: Mark
  full_name: Veraar, Mark
  last_name: Veraar
citation:
  ama: Agresti A, Veraar M. Nonlinear parabolic stochastic evolution equations in
    critical spaces part II. <i>Journal of Evolution Equations</i>. 2022;22(2). doi:<a
    href="https://doi.org/10.1007/s00028-022-00786-7">10.1007/s00028-022-00786-7</a>
  apa: Agresti, A., &#38; Veraar, M. (2022). Nonlinear parabolic stochastic evolution
    equations in critical spaces part II. <i>Journal of Evolution Equations</i>. Springer
    Nature. <a href="https://doi.org/10.1007/s00028-022-00786-7">https://doi.org/10.1007/s00028-022-00786-7</a>
  chicago: Agresti, Antonio, and Mark Veraar. “Nonlinear Parabolic Stochastic Evolution
    Equations in Critical Spaces Part II.” <i>Journal of Evolution Equations</i>.
    Springer Nature, 2022. <a href="https://doi.org/10.1007/s00028-022-00786-7">https://doi.org/10.1007/s00028-022-00786-7</a>.
  ieee: A. Agresti and M. Veraar, “Nonlinear parabolic stochastic evolution equations
    in critical spaces part II,” <i>Journal of Evolution Equations</i>, vol. 22, no.
    2. Springer Nature, 2022.
  ista: Agresti A, Veraar M. 2022. Nonlinear parabolic stochastic evolution equations
    in critical spaces part II. Journal of Evolution Equations. 22(2), 56.
  mla: Agresti, Antonio, and Mark Veraar. “Nonlinear Parabolic Stochastic Evolution
    Equations in Critical Spaces Part II.” <i>Journal of Evolution Equations</i>,
    vol. 22, no. 2, 56, Springer Nature, 2022, doi:<a href="https://doi.org/10.1007/s00028-022-00786-7">10.1007/s00028-022-00786-7</a>.
  short: A. Agresti, M. Veraar, Journal of Evolution Equations 22 (2022).
date_created: 2022-08-16T08:39:43Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2023-08-03T12:53:51Z
day: '01'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1007/s00028-022-00786-7
external_id:
  isi:
  - '000809108500001'
file:
- access_level: open_access
  checksum: 59b99d1b48b6bd40983e7ce298524a21
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  creator: kschuh
  date_created: 2022-08-16T08:52:46Z
  date_updated: 2022-08-16T08:52:46Z
  file_id: '11862'
  file_name: 2022_Journal of Evolution Equations_Agresti.pdf
  file_size: 1758371
  relation: main_file
  success: 1
file_date_updated: 2022-08-16T08:52:46Z
has_accepted_license: '1'
intvolume: '        22'
isi: 1
issue: '2'
keyword:
- Mathematics (miscellaneous)
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: Journal of Evolution Equations
publication_identifier:
  eissn:
  - 1424-3202
  issn:
  - 1424-3199
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nonlinear parabolic stochastic evolution equations in critical spaces part
  II
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2022'
...
---
_id: '11879'
abstract:
- lang: eng
  text: "As the overall global mean surface temperature is increasing due to climate
    change, plant\r\nadaptation to those stressful conditions is of utmost importance
    for their survival. Plants are\r\nsessile organisms, thus to compensate for their
    lack of mobility, they evolved a variety of\r\nmechanisms enabling them to flexibly
    adjust their physiological, growth and developmental\r\nprocesses to fluctuating
    temperatures and to survive in harsh environments. While these unique\r\nadaptation
    abilities provide an important evolutionary advantage, overall modulation of plant\r\ngrowth
    and developmental program due to non-optimal temperature negatively affects biomass\r\nproduction,
    crop productivity or sensitivity to pathogens. Thus, understanding molecular\r\nprocesses
    underlying plant adaptation to increased temperature can provide important\r\nresources
    for breeding strategies to ensure sufficient agricultural food production.\r\nAn
    increase in ambient temperature by a few degrees leads to profound changes in
    organ growth\r\nincluding enhanced hypocotyl elongation, expansion of petioles,
    hyponastic growth of leaves and\r\ncotyledons, collectively named thermomorphogenesis
    (Casal & Balasubramanian, 2019). Auxin,\r\none of the best-studied growth hormones,
    plays an essential role in this process by direct\r\nactivation of transcriptional
    and non-transcriptional processes resulting in elongation growth\r\n(Majda & Robert,
    2018).To modulate hypocotyl growth in response to high ambient temperature\r\n(hAT),
    auxin needs to be redistributed accordingly. PINs, auxin efflux transporters,
    are key\r\ncomponents of the polar auxin transport (PAT) machinery, which controls
    the amount and\r\ndirection of auxin translocated in the plant tissues and organs(Adamowski
    & Friml, 2015). Hence,\r\nPIN-mediated transport is tightly linked with thermo-morphogenesis,
    and interference with PAT\r\nthrough either chemical or genetic means dramatically
    affecting the adaptive responses to hAT.\r\nIntriguingly, despite the key role
    of PIN mediated transport in growth response to hAT, whether\r\nand how PINs at
    the level of expression adapt to fluctuation in temperature is scarcely\r\nunderstood.\r\nWith
    genetic, molecular and advanced bio-imaging approaches, we demonstrate the role
    of PIN\r\nauxin transporters in the regulation of hypocotyl growth in response
    to hAT. We show that via\r\nadjustment of PIN3, PIN4 and PIN7 expression in cotyledons
    and hypocotyls, auxin distribution is modulated thereby determining elongation
    pattern of epidermal cells at hAT. Furthermore, we\r\nidentified three Zinc-Finger
    (ZF) transcription factors as novel molecular components of the\r\nthermo-regulatory
    network, which through negative regulation of PIN transcription adjust the\r\ntransport
    of auxin at hAT. Our results suggest that the ZF-PIN module might be a part of
    the\r\nnegative feedback loop attenuating the activity of the thermo-sensing pathway
    to restrain\r\nexaggerated growth and developmental responses to hAT."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: SSU
acknowledgement: I would like to acknowledge ISTA and all the people from the Scientific
  Service Units and at ISTA, in particular Dorota Jaworska for excellent technical
  and scientific support as well as ÖAW for funding my research for over 3 years (DOC
  ÖAW Fellowship PR1022OEAW02).
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Christina
  full_name: Artner, Christina
  id: 45DF286A-F248-11E8-B48F-1D18A9856A87
  last_name: Artner
citation:
  ama: Artner C. Modulation of auxin transport via ZF proteins adjust plant response
    to high ambient temperature. 2022. doi:<a href="https://doi.org/10.15479/at:ista:11879">10.15479/at:ista:11879</a>
  apa: Artner, C. (2022). <i>Modulation of auxin transport via ZF proteins adjust
    plant response to high ambient temperature</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/at:ista:11879">https://doi.org/10.15479/at:ista:11879</a>
  chicago: Artner, Christina. “Modulation of Auxin Transport via ZF Proteins Adjust
    Plant Response to High Ambient Temperature.” Institute of Science and Technology
    Austria, 2022. <a href="https://doi.org/10.15479/at:ista:11879">https://doi.org/10.15479/at:ista:11879</a>.
  ieee: C. Artner, “Modulation of auxin transport via ZF proteins adjust plant response
    to high ambient temperature,” Institute of Science and Technology Austria, 2022.
  ista: Artner C. 2022. Modulation of auxin transport via ZF proteins adjust plant
    response to high ambient temperature. Institute of Science and Technology Austria.
  mla: Artner, Christina. <i>Modulation of Auxin Transport via ZF Proteins Adjust
    Plant Response to High Ambient Temperature</i>. Institute of Science and Technology
    Austria, 2022, doi:<a href="https://doi.org/10.15479/at:ista:11879">10.15479/at:ista:11879</a>.
  short: C. Artner, Modulation of Auxin Transport via ZF Proteins Adjust Plant Response
    to High Ambient Temperature, Institute of Science and Technology Austria, 2022.
date_created: 2022-08-17T07:58:53Z
date_published: 2022-08-17T00:00:00Z
date_updated: 2023-09-09T22:30:04Z
day: '17'
ddc:
- '580'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/at:ista:11879
file:
- access_level: open_access
  checksum: a2c2fdc28002538840490bfa6a08b2cb
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  creator: cartner
  date_created: 2022-08-17T12:08:49Z
  date_updated: 2023-09-09T22:30:03Z
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  file_id: '11908'
  file_name: ChristinaArtner_PhD_Thesis_2022.7z
  file_size: 19097730
  relation: source_file
file_date_updated: 2023-09-09T22:30:03Z
has_accepted_license: '1'
keyword:
- high ambient temperature
- auxin
- PINs
- Zinc-Finger proteins
- thermomorphogenesis
- stress
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '128'
project:
- _id: 2685A872-B435-11E9-9278-68D0E5697425
  name: Hormonal regulation of plant adaptive responses to environmental signals
publication_identifier:
  isbn:
  - 978-3-99078-022-0
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
title: Modulation of auxin transport via ZF proteins adjust plant response to high
  ambient temperature
type: dissertation
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11916'
abstract:
- lang: eng
  text: A domain is called Kac regular for a quadratic form on L2 if every functions
    vanishing almost everywhere outside the domain can be approximated in form norm
    by functions with compact support in the domain. It is shown that this notion
    is stable under domination of quadratic forms. As applications measure perturbations
    of quasi-regular Dirichlet forms, Cheeger energies on metric measure spaces and
    Schrödinger operators on manifolds are studied. Along the way a characterization
    of the Sobolev space with Dirichlet boundary conditions on domains in infinitesimally
    Riemannian metric measure spaces is obtained.
acknowledgement: "The author was supported by the German Academic Scholarship Foundation
  (Studienstiftung des deutschen Volkes) and by the German Research Foundation (DFG)
  via RTG 1523/2. The author would like to thank Daniel Lenz for his support and encouragement
  during the author’s ongoing graduate studies and him as well as Marcel Schmidt for
  fruitful discussions on domination of quadratic forms. He wants to thank Batu Güneysu
  and Peter Stollmann for valuable comments on a preliminary version of this article.
  He would also like to thank the organizers of the conference Analysis and Geometry
  on Graphs and Manifolds in Potsdam, where the initial motivation of this article
  was conceived, and the organizers of the intense activity period Metric Measure
  Spaces and Ricci Curvature at MPIM in Bonn, where this work was finished.\r\nOpen
  access funding provided by Institute of Science and Technology (IST Austria)."
article_number: '38'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Melchior
  full_name: Wirth, Melchior
  id: 88644358-0A0E-11EA-8FA5-49A33DDC885E
  last_name: Wirth
  orcid: 0000-0002-0519-4241
citation:
  ama: Wirth M. Kac regularity and domination of quadratic forms. <i>Advances in Operator
    Theory</i>. 2022;7(3). doi:<a href="https://doi.org/10.1007/s43036-022-00199-w">10.1007/s43036-022-00199-w</a>
  apa: Wirth, M. (2022). Kac regularity and domination of quadratic forms. <i>Advances
    in Operator Theory</i>. Springer Nature. <a href="https://doi.org/10.1007/s43036-022-00199-w">https://doi.org/10.1007/s43036-022-00199-w</a>
  chicago: Wirth, Melchior. “Kac Regularity and Domination of Quadratic Forms.” <i>Advances
    in Operator Theory</i>. Springer Nature, 2022. <a href="https://doi.org/10.1007/s43036-022-00199-w">https://doi.org/10.1007/s43036-022-00199-w</a>.
  ieee: M. Wirth, “Kac regularity and domination of quadratic forms,” <i>Advances
    in Operator Theory</i>, vol. 7, no. 3. Springer Nature, 2022.
  ista: Wirth M. 2022. Kac regularity and domination of quadratic forms. Advances
    in Operator Theory. 7(3), 38.
  mla: Wirth, Melchior. “Kac Regularity and Domination of Quadratic Forms.” <i>Advances
    in Operator Theory</i>, vol. 7, no. 3, 38, Springer Nature, 2022, doi:<a href="https://doi.org/10.1007/s43036-022-00199-w">10.1007/s43036-022-00199-w</a>.
  short: M. Wirth, Advances in Operator Theory 7 (2022).
date_created: 2022-08-18T07:22:24Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2023-02-21T10:08:07Z
day: '01'
ddc:
- '510'
department:
- _id: JaMa
doi: 10.1007/s43036-022-00199-w
file:
- access_level: open_access
  checksum: 913474844a1b38264fb710746d5e2e98
  content_type: application/pdf
  creator: dernst
  date_created: 2022-08-18T08:02:34Z
  date_updated: 2022-08-18T08:02:34Z
  file_id: '11921'
  file_name: 2022_AdvancesOperatorTheory_Wirth.pdf
  file_size: 389060
  relation: main_file
  success: 1
file_date_updated: 2022-08-18T08:02:34Z
has_accepted_license: '1'
intvolume: '         7'
issue: '3'
keyword:
- Algebra and Number Theory
- Analysis
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Advances in Operator Theory
publication_identifier:
  eissn:
  - 2538-225X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Kac regularity and domination of quadratic forms
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2022'
...
---
_id: '11917'
abstract:
- lang: eng
  text: We study the many-body dynamics of an initially factorized bosonic wave function
    in the mean-field regime. We prove large deviation estimates for the fluctuations
    around the condensate. We derive an upper bound extending a recent result to more
    general interactions. Furthermore, we derive a new lower bound which agrees with
    the upper bound in leading order.
acknowledgement: "The authors thank Gérard Ben Arous for pointing out the question
  of a lower bound. Funding from the European Union’s Horizon 2020 research and innovation
  programme under the ERC Grant Agreement No. 694227 (R.S.) and under the Marie Skłodowska-Curie
  Grant Agreement No. 754411 (S.R.) is gratefully acknowledged.\r\nOpen access funding
  provided by IST Austria."
article_number: '9'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Simone Anna Elvira
  full_name: Rademacher, Simone Anna Elvira
  id: 856966FE-A408-11E9-977E-802DE6697425
  last_name: Rademacher
  orcid: 0000-0001-5059-4466
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Rademacher SAE, Seiringer R. Large deviation estimates for weakly interacting
    bosons. <i>Journal of Statistical Physics</i>. 2022;188. doi:<a href="https://doi.org/10.1007/s10955-022-02940-4">10.1007/s10955-022-02940-4</a>
  apa: Rademacher, S. A. E., &#38; Seiringer, R. (2022). Large deviation estimates
    for weakly interacting bosons. <i>Journal of Statistical Physics</i>. Springer
    Nature. <a href="https://doi.org/10.1007/s10955-022-02940-4">https://doi.org/10.1007/s10955-022-02940-4</a>
  chicago: Rademacher, Simone Anna Elvira, and Robert Seiringer. “Large Deviation
    Estimates for Weakly Interacting Bosons.” <i>Journal of Statistical Physics</i>.
    Springer Nature, 2022. <a href="https://doi.org/10.1007/s10955-022-02940-4">https://doi.org/10.1007/s10955-022-02940-4</a>.
  ieee: S. A. E. Rademacher and R. Seiringer, “Large deviation estimates for weakly
    interacting bosons,” <i>Journal of Statistical Physics</i>, vol. 188. Springer
    Nature, 2022.
  ista: Rademacher SAE, Seiringer R. 2022. Large deviation estimates for weakly interacting
    bosons. Journal of Statistical Physics. 188, 9.
  mla: Rademacher, Simone Anna Elvira, and Robert Seiringer. “Large Deviation Estimates
    for Weakly Interacting Bosons.” <i>Journal of Statistical Physics</i>, vol. 188,
    9, Springer Nature, 2022, doi:<a href="https://doi.org/10.1007/s10955-022-02940-4">10.1007/s10955-022-02940-4</a>.
  short: S.A.E. Rademacher, R. Seiringer, Journal of Statistical Physics 188 (2022).
date_created: 2022-08-18T07:23:26Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2023-08-03T12:55:58Z
day: '01'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1007/s10955-022-02940-4
ec_funded: 1
external_id:
  isi:
  - '000805175000001'
file:
- access_level: open_access
  checksum: 44418cb44f07fa21ed3907f85abf7f39
  content_type: application/pdf
  creator: dernst
  date_created: 2022-08-18T08:09:00Z
  date_updated: 2022-08-18T08:09:00Z
  file_id: '11922'
  file_name: 2022_JournalStatisticalPhysics_Rademacher.pdf
  file_size: 483481
  relation: main_file
  success: 1
file_date_updated: 2022-08-18T08:09:00Z
has_accepted_license: '1'
intvolume: '       188'
isi: 1
keyword:
- Mathematical Physics
- Statistical and Nonlinear Physics
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '694227'
  name: Analysis of quantum many-body systems
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: Journal of Statistical Physics
publication_identifier:
  eissn:
  - 1572-9613
  issn:
  - 0022-4715
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Large deviation estimates for weakly interacting bosons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 188
year: '2022'
...
---
_id: '11930'
abstract:
- lang: eng
  text: We present a practically efficient algorithm for maintaining a global minimum
    cut in large dynamic graphs under both edge insertions and deletions. While there
    has been theoretical work on this problem, our algorithm is the first implementation
    of a fully-dynamic algorithm. The algorithm uses the theoretical foundation and
    combines it with efficient and finely-tuned implementations to give an algorithm
    that can maintain the global minimum cut of a graph with rapid update times. We
    show that our algorithm gives up to multiple orders of magnitude speedup compared
    to static approaches both on edge insertions and deletions.
article_processing_charge: No
arxiv: 1
author:
- first_name: Monika H
  full_name: Henzinger, Monika H
  id: 540c9bbd-f2de-11ec-812d-d04a5be85630
  last_name: Henzinger
  orcid: 0000-0002-5008-6530
- first_name: Alexander
  full_name: Noe, Alexander
  last_name: Noe
- first_name: Christian
  full_name: Schulz, Christian
  last_name: Schulz
citation:
  ama: 'Henzinger MH, Noe A, Schulz C. Practical fully dynamic minimum cut algorithms.
    In: <i>2022 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>.
    Society for Industrial and Applied Mathematics; 2022:13-26. doi:<a href="https://doi.org/10.1137/1.9781611977042.2">10.1137/1.9781611977042.2</a>'
  apa: 'Henzinger, M. H., Noe, A., &#38; Schulz, C. (2022). Practical fully dynamic
    minimum cut algorithms. In <i>2022 Proceedings of the Symposium on Algorithm Engineering
    and Experiments</i> (pp. 13–26). Alexandria, VA, United States: Society for Industrial
    and Applied Mathematics. <a href="https://doi.org/10.1137/1.9781611977042.2">https://doi.org/10.1137/1.9781611977042.2</a>'
  chicago: Henzinger, Monika H, Alexander Noe, and Christian Schulz. “Practical Fully
    Dynamic Minimum Cut Algorithms.” In <i>2022 Proceedings of the Symposium on Algorithm
    Engineering and Experiments</i>, 13–26. Society for Industrial and Applied Mathematics,
    2022. <a href="https://doi.org/10.1137/1.9781611977042.2">https://doi.org/10.1137/1.9781611977042.2</a>.
  ieee: M. H. Henzinger, A. Noe, and C. Schulz, “Practical fully dynamic minimum cut
    algorithms,” in <i>2022 Proceedings of the Symposium on Algorithm Engineering
    and Experiments</i>, Alexandria, VA, United States, 2022, pp. 13–26.
  ista: 'Henzinger MH, Noe A, Schulz C. 2022. Practical fully dynamic minimum cut
    algorithms. 2022 Proceedings of the Symposium on Algorithm Engineering and Experiments.
    ALENEX: Symposium on Algorithm Engineering and Experiments, 13–26.'
  mla: Henzinger, Monika H., et al. “Practical Fully Dynamic Minimum Cut Algorithms.”
    <i>2022 Proceedings of the Symposium on Algorithm Engineering and Experiments</i>,
    Society for Industrial and Applied Mathematics, 2022, pp. 13–26, doi:<a href="https://doi.org/10.1137/1.9781611977042.2">10.1137/1.9781611977042.2</a>.
  short: M.H. Henzinger, A. Noe, C. Schulz, in:, 2022 Proceedings of the Symposium
    on Algorithm Engineering and Experiments, Society for Industrial and Applied Mathematics,
    2022, pp. 13–26.
conference:
  end_date: 2022-01-10
  location: Alexandria, VA, United States
  name: 'ALENEX: Symposium on Algorithm Engineering and Experiments'
  start_date: 2022-01-09
date_created: 2022-08-19T07:27:51Z
date_published: 2022-01-01T00:00:00Z
date_updated: 2023-02-17T13:57:17Z
day: '01'
doi: 10.1137/1.9781611977042.2
extern: '1'
external_id:
  arxiv:
  - '2101.05033'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://arxiv.org/abs/2101.05033
month: '01'
oa: 1
oa_version: Preprint
page: 13-26
publication: 2022 Proceedings of the Symposium on Algorithm Engineering and Experiments
publication_identifier:
  eisbn:
  - 978-1-61197-704-2
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Practical fully dynamic minimum cut algorithms
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11932'
abstract:
- lang: eng
  text: "The ability to form and retrieve memories is central to survival. In mammals,
    the hippocampus\r\nis a brain region essential to the acquisition and consolidation
    of new memories. It is also\r\ninvolved in keeping track of one’s position in
    space and aids navigation. Although this\r\nspace-memory has been a source of
    contradiction, evidence supports the view that the role of\r\nthe hippocampus
    in navigation is memory, thanks to the formation of cognitive maps. First\r\nintroduced
    by Tolman in 1948, cognitive maps are generally used to organize experiences in\r\nmemory;
    however, the detailed mechanisms by which these maps are formed and stored are
    not\r\nyet agreed upon. Some influential theories describe this process as involving
    three fundamental\r\nsteps: initial encoding by the hippocampus, interactions
    between the hippocampus and other\r\ncortical areas, and long-term extra-hippocampal
    consolidation. In this thesis, I will show how\r\nthe investigation of cognitive
    maps of space helped to shed light on each of these three memory\r\nprocesses.\r\nThe
    first study included in this thesis deals with the initial encoding of spatial
    memories in\r\nthe hippocampus. Much is known about encoding at the level of single
    cells, but less about\r\ntheir co-activity or joint contribution to the encoding
    of novel spatial information. I will\r\ndescribe the structure of an interaction
    network that allows for efficient encoding of noisy\r\nspatial information during
    the first exploration of a novel environment.\r\nThe second study describes the
    interactions between the hippocampus and the prefrontal\r\ncortex (PFC), two areas
    directly and indirectly connected. It is known that the PFC, in concert\r\nwith
    the hippocampus, is involved in various processes, including memory storage and
    spatial\r\nnavigation. Nonetheless, the detailed mechanisms by which PFC receives
    information from the\r\nhippocampus are not clear. I will show how a transient
    improvement in theta phase locking of\r\nPFC cells enables interactions of cell
    pairs across the two regions.\r\nThe third study describes the learning of behaviorally-relevant
    spatial locations in the hippocampus and the medial entorhinal cortex. I will
    show how the accumulation of firing around\r\ngoal locations, a correlate of learning,
    can shed light on the transition from short- to long-term\r\nspatial memories
    and the speed of consolidation in different brain areas.\r\nThe studies included
    in this thesis represent the main scientific contributions of my Ph.D. They\r\ninvolve
    statistical analyses and models of neural responses of cells in different brain
    areas of\r\nrats executing spatial tasks. I will conclude the thesis by discussing
    the impact of the findings\r\non principles of memory formation and retention,
    including the mechanisms, the speed, and\r\nthe duration of these processes."
acknowledgement: I acknowledge the support from the European Union’s Horizon 2020
  research and innovation program under the Marie Skłodowska-Curie Grant Agreement
  No. 665385.
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Michele
  full_name: Nardin, Michele
  id: 30BD0376-F248-11E8-B48F-1D18A9856A87
  last_name: Nardin
  orcid: 0000-0001-8849-6570
citation:
  ama: Nardin M. On the encoding, transfer, and consolidation of spatial memories.
    2022. doi:<a href="https://doi.org/10.15479/at:ista:11932">10.15479/at:ista:11932</a>
  apa: Nardin, M. (2022). <i>On the encoding, transfer, and consolidation of spatial
    memories</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/at:ista:11932">https://doi.org/10.15479/at:ista:11932</a>
  chicago: Nardin, Michele. “On the Encoding, Transfer, and Consolidation of Spatial
    Memories.” Institute of Science and Technology Austria, 2022. <a href="https://doi.org/10.15479/at:ista:11932">https://doi.org/10.15479/at:ista:11932</a>.
  ieee: M. Nardin, “On the encoding, transfer, and consolidation of spatial memories,”
    Institute of Science and Technology Austria, 2022.
  ista: Nardin M. 2022. On the encoding, transfer, and consolidation of spatial memories.
    Institute of Science and Technology Austria.
  mla: Nardin, Michele. <i>On the Encoding, Transfer, and Consolidation of Spatial
    Memories</i>. Institute of Science and Technology Austria, 2022, doi:<a href="https://doi.org/10.15479/at:ista:11932">10.15479/at:ista:11932</a>.
  short: M. Nardin, On the Encoding, Transfer, and Consolidation of Spatial Memories,
    Institute of Science and Technology Austria, 2022.
date_created: 2022-08-19T08:52:30Z
date_published: 2022-08-19T00:00:00Z
date_updated: 2023-09-05T12:02:14Z
day: '19'
ddc:
- '573'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoCs
doi: 10.15479/at:ista:11932
ec_funded: 1
file:
- access_level: closed
  checksum: 2dbb70c74aaa3b64c1f463e943baf09c
  content_type: application/zip
  creator: mnardin
  date_created: 2022-08-19T16:31:34Z
  date_updated: 2023-06-20T22:30:04Z
  embargo_to: open_access
  file_id: '11935'
  file_name: Michele Nardin, Ph.D. Thesis - ISTA (1).zip
  file_size: 13515457
  relation: source_file
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  checksum: 0ec94035ea35a47a9f589ed168e60b48
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  creator: mnardin
  date_created: 2022-08-22T09:43:50Z
  date_updated: 2023-06-20T22:30:04Z
  embargo: 2023-06-19
  file_id: '11941'
  file_name: Michele_Nardin_Phd_Thesis_PDFA.pdf
  file_size: 9906458
  relation: main_file
file_date_updated: 2023-06-20T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '136'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '665385'
  name: International IST Doctoral Program
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '10077'
    relation: part_of_dissertation
    status: public
  - id: '6194'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
title: On the encoding, transfer, and consolidation of spatial memories
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '11937'
abstract:
- lang: eng
  text: Most experimentally known high-pressure ice phases have a body-centred cubic
    (bcc) oxygen lattice. Our large-scale molecular-dynamics simulations with a machine-learning
    potential indicate that, amongst these bcc ice phases, ices VII, VII′ and X are
    the same thermodynamic phase under different conditions, whereas superionic ice
    VII″ has a first-order phase boundary with ice VII′. Moreover, at about 300 GPa,
    the transformation between ice X and the Pbcm phase has a sharp structural change
    but no apparent activation barrier, whilst at higher pressures the barrier gradually
    increases. Our study thus clarifies the phase behaviour of the high-pressure ices
    and reveals peculiar solid–solid transition mechanisms not known in other systems.
acknowledgement: We thank Chris Pickard for providing the initial structures of high-pressure
  ice phases and for useful advice. A.R. and B.C. acknowledge resources provided by
  the Cambridge Tier-2 system operated by the University of Cambridge Research Computing
  Service funded by EPSRC Tier-2 capital grant EP/P020259/1. M.B. was supported by
  the European Union within the Marie Skłodowska-Curie actions (xICE grant 894725)
  and acknowledges computational resources at North-German Supercomputing Alliance
  (HLRN) facilities. S.H. and M.M. acknowledge support from LDRD 19-ERD-031 and computing
  support from the Lawrence Livermore National Laboratory (LLNL) Institutional Computing
  Grand Challenge programme. F.C. acknowledges support from the US DOE Office of Science,
  Office of Fusion Energy Sciences. Lawrence Livermore National Laboratory is operated
  by Lawrence Livermore National Security, LLC, for the U.S. Department of Energy,
  National Nuclear Security Administration under Contract DE-AC52-07NA27344.
article_number: '4707'
article_processing_charge: No
article_type: original
author:
- first_name: Aleks
  full_name: Reinhardt, Aleks
  last_name: Reinhardt
- first_name: Mandy
  full_name: Bethkenhagen, Mandy
  last_name: Bethkenhagen
- first_name: Federica
  full_name: Coppari, Federica
  last_name: Coppari
- first_name: Marius
  full_name: Millot, Marius
  last_name: Millot
- first_name: Sebastien
  full_name: Hamel, Sebastien
  last_name: Hamel
- first_name: Bingqing
  full_name: Cheng, Bingqing
  id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
  last_name: Cheng
  orcid: 0000-0002-3584-9632
citation:
  ama: Reinhardt A, Bethkenhagen M, Coppari F, Millot M, Hamel S, Cheng B. Thermodynamics
    of high-pressure ice phases explored with atomistic simulations. <i>Nature Communications</i>.
    2022;13. doi:<a href="https://doi.org/10.1038/s41467-022-32374-1">10.1038/s41467-022-32374-1</a>
  apa: Reinhardt, A., Bethkenhagen, M., Coppari, F., Millot, M., Hamel, S., &#38;
    Cheng, B. (2022). Thermodynamics of high-pressure ice phases explored with atomistic
    simulations. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-022-32374-1">https://doi.org/10.1038/s41467-022-32374-1</a>
  chicago: Reinhardt, Aleks, Mandy Bethkenhagen, Federica Coppari, Marius Millot,
    Sebastien Hamel, and Bingqing Cheng. “Thermodynamics of High-Pressure Ice Phases
    Explored with Atomistic Simulations.” <i>Nature Communications</i>. Springer Nature,
    2022. <a href="https://doi.org/10.1038/s41467-022-32374-1">https://doi.org/10.1038/s41467-022-32374-1</a>.
  ieee: A. Reinhardt, M. Bethkenhagen, F. Coppari, M. Millot, S. Hamel, and B. Cheng,
    “Thermodynamics of high-pressure ice phases explored with atomistic simulations,”
    <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.
  ista: Reinhardt A, Bethkenhagen M, Coppari F, Millot M, Hamel S, Cheng B. 2022.
    Thermodynamics of high-pressure ice phases explored with atomistic simulations.
    Nature Communications. 13, 4707.
  mla: Reinhardt, Aleks, et al. “Thermodynamics of High-Pressure Ice Phases Explored
    with Atomistic Simulations.” <i>Nature Communications</i>, vol. 13, 4707, Springer
    Nature, 2022, doi:<a href="https://doi.org/10.1038/s41467-022-32374-1">10.1038/s41467-022-32374-1</a>.
  short: A. Reinhardt, M. Bethkenhagen, F. Coppari, M. Millot, S. Hamel, B. Cheng,
    Nature Communications 13 (2022).
date_created: 2022-08-21T22:01:55Z
date_published: 2022-08-10T00:00:00Z
date_updated: 2023-08-03T13:00:40Z
day: '10'
ddc:
- '540'
department:
- _id: BiCh
doi: 10.1038/s41467-022-32374-1
external_id:
  isi:
  - '000838655300022'
  pmid:
  - '35948550'
file:
- access_level: open_access
  checksum: 8ff9b689cde59fd3a9959a9f01929dea
  content_type: application/pdf
  creator: dernst
  date_created: 2022-08-22T06:33:02Z
  date_updated: 2022-08-22T06:33:02Z
  file_id: '11939'
  file_name: 2022_NatureCommunications_Reinhardt.pdf
  file_size: 1767206
  relation: main_file
  success: 1
file_date_updated: 2022-08-22T06:33:02Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thermodynamics of high-pressure ice phases explored with atomistic simulations
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '11938'
abstract:
- lang: eng
  text: A matching is compatible to two or more labeled point sets of size n with
    labels {1, . . . , n} if its straight-line drawing on each of these point sets
    is crossing-free. We study the maximum number of edges in a matching compatible
    to two or more labeled point sets in general position in the plane. We show that
    for any two labeled sets of n points in convex position there exists a compatible
    matching with ⌊√2n + 1 − 1⌋ edges. More generally, for any ℓ labeled point sets
    we construct compatible matchings of size Ω(n1/ℓ). As a corresponding upper bound,
    we use probabilistic arguments to show that for any ℓ given sets of n points there
    exists a labeling of each set such that the largest compatible matching has O(n2/(ℓ+1))
    edges. Finally, we show that Θ(log n) copies of any set of n points are necessary
    and sufficient for the existence of labelings of these point sets such that any
    compatible matching consists only of a single edge.
acknowledgement: 'A.A. funded by the Marie Sklodowska-Curie grant agreement No 754411.
  Z.M. partially funded by Wittgenstein Prize, Austrian Science Fund (FWF), grant
  no. Z 342-N31. I.P., D.P., and B.V. partially supported by FWF within the collaborative
  DACH project Arrangements and Drawings as FWF project I 3340-N35. A.P. supported
  by a Schrödinger fellowship of the FWF: J-3847-N35. J.T. partially supported by
  ERC Start grant no. (279307: Graph Games), FWF grant no. P23499-N23 and S11407-N23
  (RiSE).'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Oswin
  full_name: Aichholzer, Oswin
  last_name: Aichholzer
- first_name: Alan M
  full_name: Arroyo Guevara, Alan M
  id: 3207FDC6-F248-11E8-B48F-1D18A9856A87
  last_name: Arroyo Guevara
  orcid: 0000-0003-2401-8670
- first_name: Zuzana
  full_name: Masárová, Zuzana
  id: 45CFE238-F248-11E8-B48F-1D18A9856A87
  last_name: Masárová
  orcid: 0000-0002-6660-1322
- first_name: Irene
  full_name: Parada, Irene
  last_name: Parada
- first_name: Daniel
  full_name: Perz, Daniel
  last_name: Perz
- first_name: Alexander
  full_name: Pilz, Alexander
  last_name: Pilz
- first_name: Josef
  full_name: Tkadlec, Josef
  id: 3F24CCC8-F248-11E8-B48F-1D18A9856A87
  last_name: Tkadlec
  orcid: 0000-0002-1097-9684
- first_name: Birgit
  full_name: Vogtenhuber, Birgit
  last_name: Vogtenhuber
citation:
  ama: Aichholzer O, Arroyo Guevara AM, Masárová Z, et al. On compatible matchings.
    <i>Journal of Graph Algorithms and Applications</i>. 2022;26(2):225-240. doi:<a
    href="https://doi.org/10.7155/jgaa.00591">10.7155/jgaa.00591</a>
  apa: Aichholzer, O., Arroyo Guevara, A. M., Masárová, Z., Parada, I., Perz, D.,
    Pilz, A., … Vogtenhuber, B. (2022). On compatible matchings. <i>Journal of Graph
    Algorithms and Applications</i>. Brown University. <a href="https://doi.org/10.7155/jgaa.00591">https://doi.org/10.7155/jgaa.00591</a>
  chicago: Aichholzer, Oswin, Alan M Arroyo Guevara, Zuzana Masárová, Irene Parada,
    Daniel Perz, Alexander Pilz, Josef Tkadlec, and Birgit Vogtenhuber. “On Compatible
    Matchings.” <i>Journal of Graph Algorithms and Applications</i>. Brown University,
    2022. <a href="https://doi.org/10.7155/jgaa.00591">https://doi.org/10.7155/jgaa.00591</a>.
  ieee: O. Aichholzer <i>et al.</i>, “On compatible matchings,” <i>Journal of Graph
    Algorithms and Applications</i>, vol. 26, no. 2. Brown University, pp. 225–240,
    2022.
  ista: Aichholzer O, Arroyo Guevara AM, Masárová Z, Parada I, Perz D, Pilz A, Tkadlec
    J, Vogtenhuber B. 2022. On compatible matchings. Journal of Graph Algorithms and
    Applications. 26(2), 225–240.
  mla: Aichholzer, Oswin, et al. “On Compatible Matchings.” <i>Journal of Graph Algorithms
    and Applications</i>, vol. 26, no. 2, Brown University, 2022, pp. 225–40, doi:<a
    href="https://doi.org/10.7155/jgaa.00591">10.7155/jgaa.00591</a>.
  short: O. Aichholzer, A.M. Arroyo Guevara, Z. Masárová, I. Parada, D. Perz, A. Pilz,
    J. Tkadlec, B. Vogtenhuber, Journal of Graph Algorithms and Applications 26 (2022)
    225–240.
date_created: 2022-08-21T22:01:56Z
date_published: 2022-06-01T00:00:00Z
date_updated: 2023-02-23T13:54:21Z
day: '01'
ddc:
- '000'
department:
- _id: UlWa
- _id: HeEd
- _id: KrCh
doi: 10.7155/jgaa.00591
ec_funded: 1
external_id:
  arxiv:
  - '2101.03928'
file:
- access_level: open_access
  checksum: dc6e255e3558faff924fd9e370886c11
  content_type: application/pdf
  creator: dernst
  date_created: 2022-08-22T06:42:42Z
  date_updated: 2022-08-22T06:42:42Z
  file_id: '11940'
  file_name: 2022_JourGraphAlgorithmsApplic_Aichholzer.pdf
  file_size: 694538
  relation: main_file
  success: 1
file_date_updated: 2022-08-22T06:42:42Z
has_accepted_license: '1'
intvolume: '        26'
issue: '2'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 225-240
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: 268116B8-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00342
  name: The Wittgenstein Prize
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '279307'
  name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P 23499-N23
  name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: S11407
  name: Game Theory
publication: Journal of Graph Algorithms and Applications
publication_identifier:
  issn:
  - 1526-1719
publication_status: published
publisher: Brown University
quality_controlled: '1'
related_material:
  record:
  - id: '9296'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: On compatible matchings
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2022'
...
---
_id: '11943'
abstract:
- lang: eng
  text: Complex wiring between neurons underlies the information-processing network
    enabling all brain functions, including cognition and memory. For understanding
    how the network is structured, processes information, and changes over time, comprehensive
    visualization of the architecture of living brain tissue with its cellular and
    molecular components would open up major opportunities. However, electron microscopy
    (EM) provides nanometre-scale resolution required for full <jats:italic>in-silico</jats:italic>
    reconstruction<jats:sup>1–5</jats:sup>, yet is limited to fixed specimens and
    static representations. Light microscopy allows live observation, with super-resolution
    approaches<jats:sup>6–12</jats:sup> facilitating nanoscale visualization, but
    comprehensive 3D-reconstruction of living brain tissue has been hindered by tissue
    photo-burden, photobleaching, insufficient 3D-resolution, and inadequate signal-to-noise
    ratio (SNR). Here we demonstrate saturated reconstruction of living brain tissue.
    We developed an integrated imaging and analysis technology, adapting stimulated
    emission depletion (STED) microscopy<jats:sup>6,13</jats:sup> in extracellularly
    labelled tissue<jats:sup>14</jats:sup> for high SNR and near-isotropic resolution.
    Centrally, a two-stage deep-learning approach leveraged previously obtained information
    on sample structure to drastically reduce photo-burden and enable automated volumetric
    reconstruction down to single synapse level. Live reconstruction provides unbiased
    analysis of tissue architecture across time in relation to functional activity
    and targeted activation, and contextual understanding of molecular labelling.
    This adoptable technology will facilitate novel insights into the dynamic functional
    architecture of living brain tissue.
article_processing_charge: No
author:
- first_name: Philipp
  full_name: Velicky, Philipp
  id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
  last_name: Velicky
  orcid: 0000-0002-2340-7431
- first_name: Eder
  full_name: Miguel Villalba, Eder
  id: 3FB91342-F248-11E8-B48F-1D18A9856A87
  last_name: Miguel Villalba
  orcid: 0000-0001-5665-0430
- first_name: Julia M
  full_name: Michalska, Julia M
  id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
  last_name: Michalska
  orcid: 0000-0003-3862-1235
- first_name: Donglai
  full_name: Wei, Donglai
  last_name: Wei
- first_name: Zudi
  full_name: Lin, Zudi
  last_name: Lin
- first_name: Jake
  full_name: Watson, Jake
  id: 63836096-4690-11EA-BD4E-32803DDC885E
  last_name: Watson
  orcid: 0000-0002-8698-3823
- first_name: Jakob
  full_name: Troidl, Jakob
  last_name: Troidl
- first_name: Johanna
  full_name: Beyer, Johanna
  last_name: Beyer
- first_name: Yoav
  full_name: Ben Simon, Yoav
  id: 43DF3136-F248-11E8-B48F-1D18A9856A87
  last_name: Ben Simon
- first_name: Christoph M
  full_name: Sommer, Christoph M
  id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
  last_name: Sommer
  orcid: 0000-0003-1216-9105
- first_name: Wiebke
  full_name: Jahr, Wiebke
  id: 425C1CE8-F248-11E8-B48F-1D18A9856A87
  last_name: Jahr
- first_name: Alban
  full_name: Cenameri, Alban
  id: 9ac8f577-2357-11eb-997a-e566c5550886
  last_name: Cenameri
- first_name: Johannes
  full_name: Broichhagen, Johannes
  last_name: Broichhagen
- first_name: Seth G. N.
  full_name: Grant, Seth G. N.
  last_name: Grant
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
- first_name: Hanspeter
  full_name: Pfister, Hanspeter
  last_name: Pfister
- first_name: Bernd
  full_name: Bickel, Bernd
  id: 49876194-F248-11E8-B48F-1D18A9856A87
  last_name: Bickel
  orcid: 0000-0001-6511-9385
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
citation:
  ama: Velicky P, Miguel Villalba E, Michalska JM, et al. Saturated reconstruction
    of living brain tissue. <i>bioRxiv</i>. doi:<a href="https://doi.org/10.1101/2022.03.16.484431">10.1101/2022.03.16.484431</a>
  apa: Velicky, P., Miguel Villalba, E., Michalska, J. M., Wei, D., Lin, Z., Watson,
    J., … Danzl, J. G. (n.d.). Saturated reconstruction of living brain tissue. <i>bioRxiv</i>.
    Cold Spring Harbor Laboratory. <a href="https://doi.org/10.1101/2022.03.16.484431">https://doi.org/10.1101/2022.03.16.484431</a>
  chicago: Velicky, Philipp, Eder Miguel Villalba, Julia M Michalska, Donglai Wei,
    Zudi Lin, Jake Watson, Jakob Troidl, et al. “Saturated Reconstruction of Living
    Brain Tissue.” <i>BioRxiv</i>. Cold Spring Harbor Laboratory, n.d. <a href="https://doi.org/10.1101/2022.03.16.484431">https://doi.org/10.1101/2022.03.16.484431</a>.
  ieee: P. Velicky <i>et al.</i>, “Saturated reconstruction of living brain tissue,”
    <i>bioRxiv</i>. Cold Spring Harbor Laboratory.
  ista: Velicky P, Miguel Villalba E, Michalska JM, Wei D, Lin Z, Watson J, Troidl
    J, Beyer J, Ben Simon Y, Sommer CM, Jahr W, Cenameri A, Broichhagen J, Grant SGN,
    Jonas PM, Novarino G, Pfister H, Bickel B, Danzl JG. Saturated reconstruction
    of living brain tissue. bioRxiv, <a href="https://doi.org/10.1101/2022.03.16.484431">10.1101/2022.03.16.484431</a>.
  mla: Velicky, Philipp, et al. “Saturated Reconstruction of Living Brain Tissue.”
    <i>BioRxiv</i>, Cold Spring Harbor Laboratory, doi:<a href="https://doi.org/10.1101/2022.03.16.484431">10.1101/2022.03.16.484431</a>.
  short: P. Velicky, E. Miguel Villalba, J.M. Michalska, D. Wei, Z. Lin, J. Watson,
    J. Troidl, J. Beyer, Y. Ben Simon, C.M. Sommer, W. Jahr, A. Cenameri, J. Broichhagen,
    S.G.N. Grant, P.M. Jonas, G. Novarino, H. Pfister, B. Bickel, J.G. Danzl, BioRxiv
    (n.d.).
date_created: 2022-08-23T11:07:59Z
date_published: 2022-05-09T00:00:00Z
date_updated: 2024-03-25T23:30:11Z
day: '09'
department:
- _id: PeJo
- _id: GaNo
- _id: BeBi
- _id: JoDa
doi: 10.1101/2022.03.16.484431
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2022.03.16.484431
month: '05'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
related_material:
  record:
  - id: '12470'
    relation: dissertation_contains
    status: public
status: public
title: Saturated reconstruction of living brain tissue
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11945'
abstract:
- lang: eng
  text: "G protein-coupled receptors (GPCRs) respond to specific ligands and regulate
    multiple processes ranging from cell growth and immune responses to neuronal signal
    transmission. However, ligands for many GPCRs remain unknown, suffer from off-target
    effects or have poor bioavailability. Additional challenges exist to dissect cell-type
    specific responses when the same GPCR is expressed on several cell types within
    the body. Here, we overcome these limitations by engineering DREADD-based GPCR
    chimeras that selectively bind their agonist clozapine-N-oxide (CNO) and mimic
    a GPCR-of-interest in a desired cell type.\r\nWe validated our approach with β2-adrenergic
    receptor (β2AR/ADRB2) and show that our chimeric DREADD-β2AR triggers comparable
    responses on second messenger and kinase activity, post-translational modifications,
    and protein-protein interactions. Since β2AR is also enriched in microglia, which
    can drive inflammation in the central nervous system, we expressed chimeric DREADD-β2AR
    in primary microglia and successfully recapitulate β2AR-mediated filopodia formation
    through CNO stimulation. To dissect the role of selected GPCRs during microglial
    inflammation, we additionally generated DREADD-based chimeras for microglia-enriched
    GPR65 and GPR109A/HCAR2. In a microglia cell line, DREADD-β2AR and DREADD-GPR65
    both modulated the inflammatory response with a similar profile as endogenously
    expressed β2AR, while DREADD-GPR109A showed no impact.\r\nOur DREADD-based approach
    provides the means to obtain mechanistic and functional insights into GPCR signaling
    on a cell-type specific level."
acknowledged_ssus:
- _id: Bio
- _id: PreCl
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Rouven
  full_name: Schulz, Rouven
  id: 4C5E7B96-F248-11E8-B48F-1D18A9856A87
  last_name: Schulz
  orcid: 0000-0001-5297-733X
citation:
  ama: Schulz R. Chimeric G protein-coupled receptors mimic distinct signaling pathways
    and modulate microglia function. 2022. doi:<a href="https://doi.org/10.15479/at:ista:11945">10.15479/at:ista:11945</a>
  apa: Schulz, R. (2022). <i>Chimeric G protein-coupled receptors mimic distinct signaling
    pathways and modulate microglia function</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/at:ista:11945">https://doi.org/10.15479/at:ista:11945</a>
  chicago: Schulz, Rouven. “Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
    Pathways and Modulate Microglia Function.” Institute of Science and Technology
    Austria, 2022. <a href="https://doi.org/10.15479/at:ista:11945">https://doi.org/10.15479/at:ista:11945</a>.
  ieee: R. Schulz, “Chimeric G protein-coupled receptors mimic distinct signaling
    pathways and modulate microglia function,” Institute of Science and Technology
    Austria, 2022.
  ista: Schulz R. 2022. Chimeric G protein-coupled receptors mimic distinct signaling
    pathways and modulate microglia function. Institute of Science and Technology
    Austria.
  mla: Schulz, Rouven. <i>Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
    Pathways and Modulate Microglia Function</i>. Institute of Science and Technology
    Austria, 2022, doi:<a href="https://doi.org/10.15479/at:ista:11945">10.15479/at:ista:11945</a>.
  short: R. Schulz, Chimeric G Protein-Coupled Receptors Mimic Distinct Signaling
    Pathways and Modulate Microglia Function, Institute of Science and Technology
    Austria, 2022.
date_created: 2022-08-23T11:33:11Z
date_published: 2022-08-23T00:00:00Z
date_updated: 2023-08-03T13:02:26Z
day: '23'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SaSi
doi: 10.15479/at:ista:11945
file:
- access_level: open_access
  checksum: 61b1b666a210ff7cdd0e95ea75207a13
  content_type: application/pdf
  creator: rschulz
  date_created: 2022-08-25T08:59:57Z
  date_updated: 2022-08-25T08:59:57Z
  file_id: '11970'
  file_name: Thesis_Rouven_Schulz_2022_final.pdf
  file_size: 28079331
  relation: main_file
  success: 1
- access_level: closed
  checksum: 2b8f95ea1c134dbdb927b41b1dbeeeb5
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: rschulz
  date_created: 2022-08-25T09:00:11Z
  date_updated: 2022-08-25T09:33:31Z
  file_id: '11971'
  file_name: Thesis_Rouven_Schulz_2022_final.docx
  file_size: 27226963
  relation: source_file
file_date_updated: 2022-08-25T09:33:31Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '133'
project:
- _id: 267F75D8-B435-11E9-9278-68D0E5697425
  name: Modulating microglia through G protein-coupled receptor (GPCR) signaling
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '11995'
    relation: dissertation_contains
    status: public
status: public
supervisor:
- first_name: Sandra
  full_name: Siegert, Sandra
  id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
  last_name: Siegert
  orcid: 0000-0001-8635-0877
title: Chimeric G protein-coupled receptors mimic distinct signaling pathways and
  modulate microglia function
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2022'
...
---
_id: '11950'
abstract:
- lang: eng
  text: Mapping the complex and dense arrangement of cells and their connectivity
    in brain tissue demands nanoscale spatial resolution imaging. Super-resolution
    optical microscopy excels at visualizing specific molecules and individual cells
    but fails to provide tissue context. Here we developed Comprehensive Analysis
    of Tissues across Scales (CATS), a technology to densely map brain tissue architecture
    from millimeter regional to nanoscopic synaptic scales in diverse chemically fixed
    brain preparations, including rodent and human. CATS leverages fixation-compatible
    extracellular labeling and advanced optical readout, in particular stimulated-emission
    depletion and expansion microscopy, to comprehensively delineate cellular structures.
    It enables 3D-reconstructing single synapses and mapping synaptic connectivity
    by identification and tailored analysis of putative synaptic cleft regions. Applying
    CATS to the hippocampal mossy fiber circuitry, we demonstrate its power to reveal
    the system’s molecularly informed ultrastructure across spatial scales and assess
    local connectivity by reconstructing and quantifying the synaptic input and output
    structure of identified neurons.
article_processing_charge: No
author:
- first_name: Julia M
  full_name: Michalska, Julia M
  id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
  last_name: Michalska
  orcid: 0000-0003-3862-1235
- first_name: Julia
  full_name: Lyudchik, Julia
  id: 46E28B80-F248-11E8-B48F-1D18A9856A87
  last_name: Lyudchik
- first_name: Philipp
  full_name: Velicky, Philipp
  id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
  last_name: Velicky
  orcid: 0000-0002-2340-7431
- first_name: Hana
  full_name: Korinkova, Hana
  id: ee3cb6ca-ec98-11ea-ae11-ff703e2254ed
  last_name: Korinkova
- first_name: Jake
  full_name: Watson, Jake
  id: 63836096-4690-11EA-BD4E-32803DDC885E
  last_name: Watson
  orcid: 0000-0002-8698-3823
- first_name: Alban
  full_name: Cenameri, Alban
  id: 9ac8f577-2357-11eb-997a-e566c5550886
  last_name: Cenameri
- first_name: Christoph M
  full_name: Sommer, Christoph M
  id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
  last_name: Sommer
  orcid: 0000-0003-1216-9105
- first_name: Alessandro
  full_name: Venturino, Alessandro
  id: 41CB84B2-F248-11E8-B48F-1D18A9856A87
  last_name: Venturino
  orcid: 0000-0003-2356-9403
- first_name: Karl
  full_name: Roessler, Karl
  last_name: Roessler
- first_name: Thomas
  full_name: Czech, Thomas
  last_name: Czech
- first_name: Sandra
  full_name: Siegert, Sandra
  id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
  last_name: Siegert
  orcid: 0000-0001-8635-0877
- first_name: Gaia
  full_name: Novarino, Gaia
  id: 3E57A680-F248-11E8-B48F-1D18A9856A87
  last_name: Novarino
  orcid: 0000-0002-7673-7178
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
citation:
  ama: Michalska JM, Lyudchik J, Velicky P, et al. Uncovering brain tissue architecture
    across scales with super-resolution light microscopy. <i>bioRxiv</i>. doi:<a href="https://doi.org/10.1101/2022.08.17.504272">10.1101/2022.08.17.504272</a>
  apa: Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri,
    A., … Danzl, J. G. (n.d.). Uncovering brain tissue architecture across scales
    with super-resolution light microscopy. <i>bioRxiv</i>. Cold Spring Harbor Laboratory.
    <a href="https://doi.org/10.1101/2022.08.17.504272">https://doi.org/10.1101/2022.08.17.504272</a>
  chicago: Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake
    Watson, Alban Cenameri, Christoph M Sommer, et al. “Uncovering Brain Tissue Architecture
    across Scales with Super-Resolution Light Microscopy.” <i>BioRxiv</i>. Cold Spring
    Harbor Laboratory, n.d. <a href="https://doi.org/10.1101/2022.08.17.504272">https://doi.org/10.1101/2022.08.17.504272</a>.
  ieee: J. M. Michalska <i>et al.</i>, “Uncovering brain tissue architecture across
    scales with super-resolution light microscopy,” <i>bioRxiv</i>. Cold Spring Harbor
    Laboratory.
  ista: Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer
    CM, Venturino A, Roessler K, Czech T, Siegert S, Novarino G, Jonas PM, Danzl JG.
    Uncovering brain tissue architecture across scales with super-resolution light
    microscopy. bioRxiv, <a href="https://doi.org/10.1101/2022.08.17.504272">10.1101/2022.08.17.504272</a>.
  mla: Michalska, Julia M., et al. “Uncovering Brain Tissue Architecture across Scales
    with Super-Resolution Light Microscopy.” <i>BioRxiv</i>, Cold Spring Harbor Laboratory,
    doi:<a href="https://doi.org/10.1101/2022.08.17.504272">10.1101/2022.08.17.504272</a>.
  short: J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri,
    C.M. Sommer, A. Venturino, K. Roessler, T. Czech, S. Siegert, G. Novarino, P.M.
    Jonas, J.G. Danzl, BioRxiv (n.d.).
date_created: 2022-08-24T08:24:52Z
date_published: 2022-08-18T00:00:00Z
date_updated: 2024-03-25T23:30:11Z
day: '18'
department:
- _id: SaSi
- _id: GaNo
- _id: PeJo
- _id: JoDa
doi: 10.1101/2022.08.17.504272
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2022.08.17.504272
month: '08'
oa: 1
oa_version: Preprint
publication: bioRxiv
publication_status: submitted
publisher: Cold Spring Harbor Laboratory
related_material:
  record:
  - id: '12470'
    relation: dissertation_contains
    status: public
status: public
title: Uncovering brain tissue architecture across scales with super-resolution light
  microscopy
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2022'
...
---
_id: '11951'
abstract:
- lang: eng
  text: The mammalian hippocampal formation (HF) plays a key role in several higher
    brain functions, such as spatial coding, learning and memory. Its simple circuit
    architecture is often viewed as a trisynaptic loop, processing input originating
    from the superficial layers of the entorhinal cortex (EC) and sending it back
    to its deeper layers. Here, we show that excitatory neurons in layer 6b of the
    mouse EC project to all sub-regions comprising the HF and receive input from the
    CA1, thalamus and claustrum. Furthermore, their output is characterized by unique
    slow-decaying excitatory postsynaptic currents capable of driving plateau-like
    potentials in their postsynaptic targets. Optogenetic inhibition of the EC-6b
    pathway affects spatial coding in CA1 pyramidal neurons, while cell ablation impairs
    not only acquisition of new spatial memories, but also degradation of previously
    acquired ones. Our results provide evidence of a functional role for cortical
    layer 6b neurons in the adult brain.
acknowledged_ssus:
- _id: Bio
- _id: SSU
acknowledgement: We thank F. Marr and A. Schlögl for technical assistance, E. Kralli-Beller
  for manuscript editing, as well as C. Sommer and the Imaging and Optics Facility
  of the Institute of Science and Technology Austria (ISTA) for image analysis scripts
  and microscopy support. We extend our gratitude to J. Wallenschus and D. Rangel
  Guerrero for technical assistance acquiring single-unit data and I. Gridchyn for
  help with single-unit clustering. Finally, we also thank B. Suter for discussions,
  A. Saunders, M. Jösch, and H. Monyer for critically reading earlier versions of
  the manuscript, C. Petersen for sharing clearing protocols, and the Scientific Service
  Units of ISTA for efficient support. This project was funded by the European Research
  Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (ERC advanced grant No 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen
  Forschung (Z 312-B27, Wittgenstein award for P.J. and I3600-B27 for J.G.D. and P.V.).
article_number: '4826'
article_processing_charge: No
article_type: original
author:
- first_name: Yoav
  full_name: Ben Simon, Yoav
  id: 43DF3136-F248-11E8-B48F-1D18A9856A87
  last_name: Ben Simon
- first_name: Karola
  full_name: Käfer, Karola
  id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
  last_name: Käfer
- first_name: Philipp
  full_name: Velicky, Philipp
  id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
  last_name: Velicky
  orcid: 0000-0002-2340-7431
- first_name: Jozsef L
  full_name: Csicsvari, Jozsef L
  id: 3FA14672-F248-11E8-B48F-1D18A9856A87
  last_name: Csicsvari
  orcid: 0000-0002-5193-4036
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Ben Simon Y, Käfer K, Velicky P, Csicsvari JL, Danzl JG, Jonas PM. A direct
    excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes
    to spatial coding and memory. <i>Nature Communications</i>. 2022;13. doi:<a href="https://doi.org/10.1038/s41467-022-32559-8">10.1038/s41467-022-32559-8</a>
  apa: Ben Simon, Y., Käfer, K., Velicky, P., Csicsvari, J. L., Danzl, J. G., &#38;
    Jonas, P. M. (2022). A direct excitatory projection from entorhinal layer 6b neurons
    to the hippocampus contributes to spatial coding and memory. <i>Nature Communications</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41467-022-32559-8">https://doi.org/10.1038/s41467-022-32559-8</a>
  chicago: Ben Simon, Yoav, Karola Käfer, Philipp Velicky, Jozsef L Csicsvari, Johann
    G Danzl, and Peter M Jonas. “A Direct Excitatory Projection from Entorhinal Layer
    6b Neurons to the Hippocampus Contributes to Spatial Coding and Memory.” <i>Nature
    Communications</i>. Springer Nature, 2022. <a href="https://doi.org/10.1038/s41467-022-32559-8">https://doi.org/10.1038/s41467-022-32559-8</a>.
  ieee: Y. Ben Simon, K. Käfer, P. Velicky, J. L. Csicsvari, J. G. Danzl, and P. M.
    Jonas, “A direct excitatory projection from entorhinal layer 6b neurons to the
    hippocampus contributes to spatial coding and memory,” <i>Nature Communications</i>,
    vol. 13. Springer Nature, 2022.
  ista: Ben Simon Y, Käfer K, Velicky P, Csicsvari JL, Danzl JG, Jonas PM. 2022. A
    direct excitatory projection from entorhinal layer 6b neurons to the hippocampus
    contributes to spatial coding and memory. Nature Communications. 13, 4826.
  mla: Ben Simon, Yoav, et al. “A Direct Excitatory Projection from Entorhinal Layer
    6b Neurons to the Hippocampus Contributes to Spatial Coding and Memory.” <i>Nature
    Communications</i>, vol. 13, 4826, Springer Nature, 2022, doi:<a href="https://doi.org/10.1038/s41467-022-32559-8">10.1038/s41467-022-32559-8</a>.
  short: Y. Ben Simon, K. Käfer, P. Velicky, J.L. Csicsvari, J.G. Danzl, P.M. Jonas,
    Nature Communications 13 (2022).
date_created: 2022-08-24T08:25:50Z
date_published: 2022-08-16T00:00:00Z
date_updated: 2023-08-03T13:01:19Z
day: '16'
ddc:
- '570'
department:
- _id: JoCs
- _id: PeJo
- _id: JoDa
doi: 10.1038/s41467-022-32559-8
ec_funded: 1
external_id:
  isi:
  - '000841396400008'
file:
- access_level: open_access
  checksum: 405936d9e4d33625d80c093c9713a91f
  content_type: application/pdf
  creator: dernst
  date_created: 2022-08-26T11:51:40Z
  date_updated: 2022-08-26T11:51:40Z
  file_id: '11990'
  file_name: 2022_NatureCommunications_BenSimon.pdf
  file_size: 5910357
  relation: main_file
  success: 1
file_date_updated: 2022-08-26T11:51:40Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
keyword:
- General Physics and Astronomy
- General Biochemistry
- Genetics and Molecular Biology
- General Chemistry
- Multidisciplinary
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 265CB4D0-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: I03600
  name: Optical control of synaptic function via adhesion molecules
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: Z00312
  name: The Wittgenstein Prize
publication: Nature Communications
publication_identifier:
  issn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus
  contributes to spatial coding and memory
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2022'
...
---
_id: '11955'
abstract:
- lang: eng
  text: Covalent organic frameworks (COFs) are structurally tuneable, porous and crystalline
    polymers constructed through the covalent attachment of small organic building
    blocks as elementary units. Using the myriad of such building blocks, a broad
    spectrum of functionalities has been applied for COF syntheses for broad applications,
    including heterogeneous catalysis. Herein, we report the synthesis of a new family
    of porous and crystalline COFs using a novel acridine linker and benzene-1,3,5-tricarbaldehyde
    derivatives bearing a variable number of hydroxy groups. With the broad absorption
    in the visible light region, the COFs were applied as photocatalysts in metallaphotocatalytic
    C−N cross-coupling. The fully β-ketoenamine linked COF showed the highest activity,
    due to the increased charge separation upon irradiation. The COF showed good to
    excellent yields for several aryl bromides, good recyclability and even catalyzed
    the organic transformation in presence of green light as energy source.
article_number: e202117738
article_processing_charge: No
article_type: original
author:
- first_name: Michael
  full_name: Traxler, Michael
  last_name: Traxler
- first_name: Sebastian
  full_name: Gisbertz, Sebastian
  last_name: Gisbertz
- first_name: Pradip
  full_name: Pachfule, Pradip
  last_name: Pachfule
- first_name: Johannes
  full_name: Schmidt, Johannes
  last_name: Schmidt
- first_name: Jérôme
  full_name: Roeser, Jérôme
  last_name: Roeser
- first_name: Susanne
  full_name: Reischauer, Susanne
  last_name: Reischauer
- first_name: Jabor
  full_name: Rabeah, Jabor
  last_name: Rabeah
- first_name: Bartholomäus
  full_name: Pieber, Bartholomäus
  id: 93e5e5b2-0da6-11ed-8a41-af589a024726
  last_name: Pieber
  orcid: 0000-0001-8689-388X
- first_name: Arne
  full_name: Thomas, Arne
  last_name: Thomas
citation:
  ama: Traxler M, Gisbertz S, Pachfule P, et al. Acridine‐functionalized covalent
    organic frameworks (COFs) as photocatalysts for metallaphotocatalytic C−N cross‐coupling.
    <i>Angewandte Chemie International Edition</i>. 2022;61(21). doi:<a href="https://doi.org/10.1002/anie.202117738">10.1002/anie.202117738</a>
  apa: Traxler, M., Gisbertz, S., Pachfule, P., Schmidt, J., Roeser, J., Reischauer,
    S., … Thomas, A. (2022). Acridine‐functionalized covalent organic frameworks (COFs)
    as photocatalysts for metallaphotocatalytic C−N cross‐coupling. <i>Angewandte
    Chemie International Edition</i>. Wiley. <a href="https://doi.org/10.1002/anie.202117738">https://doi.org/10.1002/anie.202117738</a>
  chicago: Traxler, Michael, Sebastian Gisbertz, Pradip Pachfule, Johannes Schmidt,
    Jérôme Roeser, Susanne Reischauer, Jabor Rabeah, Bartholomäus Pieber, and Arne
    Thomas. “Acridine‐functionalized Covalent Organic Frameworks (COFs) as Photocatalysts
    for Metallaphotocatalytic C−N Cross‐coupling.” <i>Angewandte Chemie International
    Edition</i>. Wiley, 2022. <a href="https://doi.org/10.1002/anie.202117738">https://doi.org/10.1002/anie.202117738</a>.
  ieee: M. Traxler <i>et al.</i>, “Acridine‐functionalized covalent organic frameworks
    (COFs) as photocatalysts for metallaphotocatalytic C−N cross‐coupling,” <i>Angewandte
    Chemie International Edition</i>, vol. 61, no. 21. Wiley, 2022.
  ista: Traxler M, Gisbertz S, Pachfule P, Schmidt J, Roeser J, Reischauer S, Rabeah
    J, Pieber B, Thomas A. 2022. Acridine‐functionalized covalent organic frameworks
    (COFs) as photocatalysts for metallaphotocatalytic C−N cross‐coupling. Angewandte
    Chemie International Edition. 61(21), e202117738.
  mla: Traxler, Michael, et al. “Acridine‐functionalized Covalent Organic Frameworks
    (COFs) as Photocatalysts for Metallaphotocatalytic C−N Cross‐coupling.” <i>Angewandte
    Chemie International Edition</i>, vol. 61, no. 21, e202117738, Wiley, 2022, doi:<a
    href="https://doi.org/10.1002/anie.202117738">10.1002/anie.202117738</a>.
  short: M. Traxler, S. Gisbertz, P. Pachfule, J. Schmidt, J. Roeser, S. Reischauer,
    J. Rabeah, B. Pieber, A. Thomas, Angewandte Chemie International Edition 61 (2022).
date_created: 2022-08-24T10:41:25Z
date_published: 2022-05-16T00:00:00Z
date_updated: 2023-02-21T10:09:11Z
day: '16'
doi: 10.1002/anie.202117738
extern: '1'
external_id:
  pmid:
  - '35188714'
intvolume: '        61'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1002/anie.202117738
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Angewandte Chemie International Edition
publication_identifier:
  eissn:
  - 1521-3773
  issn:
  - 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Acridine‐functionalized covalent organic frameworks (COFs) as photocatalysts
  for metallaphotocatalytic C−N cross‐coupling
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 61
year: '2022'
...
---
_id: '11991'
abstract:
- lang: eng
  text: The study of the complexity of the constraint satisfaction problem (CSP),
    centred around the Feder-Vardi Dichotomy Conjecture, has been very prominent in
    the last two decades. After a long concerted effort and many partial results,
    the Dichotomy Conjecture has been proved in 2017 independently by Bulatov and
    Zhuk. At about the same time, a vast generalisation of CSP, called promise CSP,
    has started to gain prominence. In this survey, we explain the importance of promise
    CSP and highlight many new very interesting features that the study of promise
    CSP has brought to light. The complexity classification quest for the promise
    CSP is wide open, and we argue that, despite the promise CSP being more general,
    this quest is rather more accessible to a wide range of researchers than the dichotomy-led
    study of the CSP has been.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Andrei
  full_name: Krokhin, Andrei
  last_name: Krokhin
- first_name: Jakub
  full_name: Opršal, Jakub
  id: ec596741-c539-11ec-b829-c79322a91242
  last_name: Opršal
  orcid: 0000-0003-1245-3456
citation:
  ama: Krokhin A, Opršal J. An invitation to the promise constraint satisfaction problem.
    <i>ACM SIGLOG News</i>. 2022;9(3):30-59. doi:<a href="https://doi.org/10.1145/3559736.3559740">10.1145/3559736.3559740</a>
  apa: Krokhin, A., &#38; Opršal, J. (2022). An invitation to the promise constraint
    satisfaction problem. <i>ACM SIGLOG News</i>. Association for Computing Machinery.
    <a href="https://doi.org/10.1145/3559736.3559740">https://doi.org/10.1145/3559736.3559740</a>
  chicago: Krokhin, Andrei, and Jakub Opršal. “An Invitation to the Promise Constraint
    Satisfaction Problem.” <i>ACM SIGLOG News</i>. Association for Computing Machinery,
    2022. <a href="https://doi.org/10.1145/3559736.3559740">https://doi.org/10.1145/3559736.3559740</a>.
  ieee: A. Krokhin and J. Opršal, “An invitation to the promise constraint satisfaction
    problem,” <i>ACM SIGLOG News</i>, vol. 9, no. 3. Association for Computing Machinery,
    pp. 30–59, 2022.
  ista: Krokhin A, Opršal J. 2022. An invitation to the promise constraint satisfaction
    problem. ACM SIGLOG News. 9(3), 30–59.
  mla: Krokhin, Andrei, and Jakub Opršal. “An Invitation to the Promise Constraint
    Satisfaction Problem.” <i>ACM SIGLOG News</i>, vol. 9, no. 3, Association for
    Computing Machinery, 2022, pp. 30–59, doi:<a href="https://doi.org/10.1145/3559736.3559740">10.1145/3559736.3559740</a>.
  short: A. Krokhin, J. Opršal, ACM SIGLOG News 9 (2022) 30–59.
date_created: 2022-08-27T11:23:37Z
date_published: 2022-07-01T00:00:00Z
date_updated: 2022-09-05T08:19:38Z
day: '01'
department:
- _id: UlWa
doi: 10.1145/3559736.3559740
external_id:
  arxiv:
  - '2208.13538'
intvolume: '         9'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/2208.13538
month: '07'
oa: 1
oa_version: Preprint
page: 30-59
publication: ACM SIGLOG News
publication_identifier:
  issn:
  - 2372-3491
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
status: public
title: An invitation to the promise constraint satisfaction problem
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2022'
...
