---
_id: '2538'
abstract:
- lang: eng
text: Rat mRNAs encoding two subtypes of the endothelin (ET) receptor (ET(A) and
ET(B)) were studied in the rat ovary and fallopian tube by means of Northern blotting
and in situ hybridization. The mRNA transcripts for the endothelin- 1-specific
type receptor (ET(A)) in pooled RNA from the ovary and fallopian tube were 4.2
and 5.2 kilonucleotides, and that for the nonselective type receptor (ET(B)) was
4.7 kilonucleotides; these were similar to transcripts for endothelin receptors
from other tissues. ET(A) mRNA expression was abundant in the muscle cell layer
of the fallopian tube, but low in the ovary. On the other hand, ET(B) mRNA was
abundant in the granulosa cells in the developing follicles, but low in atretic
follicles and absent in the fallopian tube. These results demonstrated that the
mRNAs for the two subtypes of the rat endothelin receptor have different expression
profiles in the ovary and fallopian tube. ETs may mainly affect the granulosa
cells in the dominant follicles as well as the muscle cells of the fallopian tube
through ET(B) and ET(A), respectively.
acknowledgement: We thank Ms. Fumiko Kosaka for her excellent technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Masazumi
full_name: Iwai, Masazumi
last_name: Iwai
- first_name: Seiji
full_name: Hori, Seiji
last_name: Hori
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Hideharu
full_name: Kanzaki, Hideharu
last_name: Kanzaki
- first_name: Takahide
full_name: Mori, Takahide
last_name: Mori
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Iwai M, Hori S, Shigemoto R, Kanzaki H, Mori T, Nakanishi S. Localization of
endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian
tube by in situ hybridization. Biology of Reproduction. 1993;49(4):675-680.
doi:10.1095/biolreprod49.4.675
apa: Iwai, M., Hori, S., Shigemoto, R., Kanzaki, H., Mori, T., & Nakanishi,
S. (1993). Localization of endothelin receptor messenger ribonucleic acid in the
rat ovary and fallopian tube by in situ hybridization. Biology of Reproduction.
Society for the Study of Reproduction. https://doi.org/10.1095/biolreprod49.4.675
chicago: Iwai, Masazumi, Seiji Hori, Ryuichi Shigemoto, Hideharu Kanzaki, Takahide
Mori, and Shigetada Nakanishi. “Localization of Endothelin Receptor Messenger
Ribonucleic Acid in the Rat Ovary and Fallopian Tube by in Situ Hybridization.”
Biology of Reproduction. Society for the Study of Reproduction, 1993. https://doi.org/10.1095/biolreprod49.4.675.
ieee: M. Iwai, S. Hori, R. Shigemoto, H. Kanzaki, T. Mori, and S. Nakanishi, “Localization
of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian
tube by in situ hybridization,” Biology of Reproduction, vol. 49, no. 4.
Society for the Study of Reproduction, pp. 675–680, 1993.
ista: Iwai M, Hori S, Shigemoto R, Kanzaki H, Mori T, Nakanishi S. 1993. Localization
of endothelin receptor messenger ribonucleic acid in the rat ovary and fallopian
tube by in situ hybridization. Biology of Reproduction. 49(4), 675–680.
mla: Iwai, Masazumi, et al. “Localization of Endothelin Receptor Messenger Ribonucleic
Acid in the Rat Ovary and Fallopian Tube by in Situ Hybridization.” Biology
of Reproduction, vol. 49, no. 4, Society for the Study of Reproduction, 1993,
pp. 675–80, doi:10.1095/biolreprod49.4.675.
short: M. Iwai, S. Hori, R. Shigemoto, H. Kanzaki, T. Mori, S. Nakanishi, Biology
of Reproduction 49 (1993) 675–680.
date_created: 2018-12-11T11:58:16Z
date_published: 1993-10-01T00:00:00Z
date_updated: 2022-03-31T12:32:51Z
day: '01'
doi: 10.1095/biolreprod49.4.675
extern: '1'
external_id:
pmid:
- '8218631'
intvolume: ' 49'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/biolreprod/article/49/4/675/2762375?login=true
month: '10'
oa: 1
oa_version: Published Version
page: 675 - 680
pmid: 1
publication: Biology of Reproduction
publication_identifier:
issn:
- 0006-3363
publication_status: published
publisher: Society for the Study of Reproduction
publist_id: '4359'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localization of endothelin receptor messenger ribonucleic acid in the rat ovary
and fallopian tube by in situ hybridization
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 49
year: '1993'
...
---
_id: '2539'
abstract:
- lang: eng
text: cDNA clones for four different N-methyl-D-aspartate (NMDA) receptor subunits
(NMDAR2A-NMDAR2D) were isolated through polymerase chain reactions followed by
molecular screening of a rat brain cDNA library. These subunits are only about
15% identical with the key subunit of the NMDA receptor (NMDAR1) but are highly
homologous (~50% homology) with one another. They also commonly possess large
hydrophilic domains at both amino- and carboxyl- terminal sides of the four putative
transmembrane segments. NMDAR2A and NMDAR2C expressed individually in Xenopus
oocytes showed no electrophysiological response to agonists. However, these subunits
in combined expression with NMDAR1 markedly potentiated the NMDAR1 activity and
produced functional variability in the affinity of agonists, the effectiveness
of antagonists, and the sensitivity to Mg2+ blockade. Thus, NMDAR1 is essential
for the function of the NMDA receptor, and multiple NMDAR2 subunits potentiate
and differentiate the function of the NMDA receptor by forming different heteromeric
configurations with NMDAR1. Northern blotting and in situ hybridization analyses
revealed that the expressions of individual mRNAs for the NMDAR2 subunits overlap
in some brain regions but are also specialized in many other regions. This investigation
demonstrates the anatomical and functional differences of the NMDAR2 subunits,
which provide the molecular basis for the functional diversity of the NMDA receptor.
acknowledgement: This work was supported in part by research grants from the Ministry
of Education, Science, and Culture of Japan, the Ministry of Health and Welfare
of Japan, the Senri Life Science Foundation, and Yamanouchi Foundation for Research
on Metabolic Disorders. The costs of publication of this article were defrayed in
part by the payment of page charges. This article must therefore be hereby marked
“aduertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this
fact.
article_processing_charge: No
article_type: original
author:
- first_name: Takahiro
full_name: Ishii, Takahiro
last_name: Ishii
- first_name: Koki
full_name: Moriyoshi, Koki
last_name: Moriyoshi
- first_name: Hidemitsu
full_name: Sugihara, Hidemitsu
last_name: Sugihara
- first_name: Kazuhir
full_name: Sakurada, Kazuhir
last_name: Sakurada
- first_name: Hiroshi
full_name: Kadotani, Hiroshi
last_name: Kadotani
- first_name: Mineto
full_name: Yokoi, Mineto
last_name: Yokoi
- first_name: Chihiro
full_name: Akazawa, Chihiro
last_name: Akazawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Masayuki
full_name: Masu, Masayuki
last_name: Masu
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Ishii T, Moriyoshi K, Sugihara H, et al. Molecular characterization of the
family of the N-methyl-D-aspartate receptor subunits. Journal of Biological
Chemistry. 1993;268(4):2836-2843. doi:10.1016/s0021-9258(18)53849-7
apa: Ishii, T., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi,
M., … Nakanishi, S. (1993). Molecular characterization of the family of the N-methyl-D-aspartate
receptor subunits. Journal of Biological Chemistry. American Society for
Biochemistry and Molecular Biology. https://doi.org/10.1016/s0021-9258(18)53849-7
chicago: Ishii, Takahiro, Koki Moriyoshi, Hidemitsu Sugihara, Kazuhir Sakurada,
Hiroshi Kadotani, Mineto Yokoi, Chihiro Akazawa, et al. “Molecular Characterization
of the Family of the N-Methyl-D-Aspartate Receptor Subunits.” Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology, 1993.
https://doi.org/10.1016/s0021-9258(18)53849-7
.
ieee: T. Ishii et al., “Molecular characterization of the family of the N-methyl-D-aspartate
receptor subunits,” Journal of Biological Chemistry, vol. 268, no. 4. American
Society for Biochemistry and Molecular Biology, pp. 2836–2843, 1993.
ista: Ishii T, Moriyoshi K, Sugihara H, Sakurada K, Kadotani H, Yokoi M, Akazawa
C, Shigemoto R, Mizuno N, Masu M, Nakanishi S. 1993. Molecular characterization
of the family of the N-methyl-D-aspartate receptor subunits. Journal of Biological
Chemistry. 268(4), 2836–2843.
mla: Ishii, Takahiro, et al. “Molecular Characterization of the Family of the N-Methyl-D-Aspartate
Receptor Subunits.” Journal of Biological Chemistry, vol. 268, no. 4, American
Society for Biochemistry and Molecular Biology, 1993, pp. 2836–43, doi:10.1016/s0021-9258(18)53849-7 .
short: T. Ishii, K. Moriyoshi, H. Sugihara, K. Sakurada, H. Kadotani, M. Yokoi,
C. Akazawa, R. Shigemoto, N. Mizuno, M. Masu, S. Nakanishi, Journal of Biological
Chemistry 268 (1993) 2836–2843.
date_created: 2018-12-11T11:58:16Z
date_published: 1993-02-05T00:00:00Z
date_updated: 2022-03-31T14:29:17Z
day: '05'
doi: '10.1016/s0021-9258(18)53849-7 '
extern: '1'
external_id:
pmid:
- '8428958'
intvolume: ' 268'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.jbc.org/article/S0021-9258(18)53849-7/fulltext
month: '02'
oa: 1
oa_version: Published Version
page: 2836 - 2843
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4360'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of the family of the N-methyl-D-aspartate receptor
subunits
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 268
year: '1993'
...
---
_id: '3470'
abstract:
- lang: eng
text: Currents activated by glutamate receptor (GluR) agonists were recorded from
outside-out patches isolated from the soma of visually identified pyramidal neurones
of the (CA3 and CA1 region of rat hippocampal slices. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA). L-glutamate (L-Glu), and kainate (KA) were delivered either by bath
application through perfusion of the recording chamber or by rapid application
via a piezo-driven two-barrelled fast application system. 2. Bath application
of each of the three agonists activated inward currents in all patches (n = 134)
at holding potentials of -50 or -60 mV. The current amplitude increased in size
between 3 to 30 μM-AMPA and 100 μM to 1 mM-KA. With this slow mode of bath application,
the responses showed no apparent desensitization even at saturating concentrations
of AMPA (30 μM) and KA (1 mM). 3. The ratio of currents activated by 30 μM-AMPA
and 300 μM-KA showed a characteristic difference between CA3 and CA1 neurones.
The ratio was 0.242 ± 0.028 (mean ± S.E.M., n = 16) for CA3 cell patches and 0.097
± 0.012 (n = 8) for CA1 cell patches indicating that GluRs in the two cell populations
are different. 4. The steady-state current-voltage relations (I-Vs) for AMPA-
and KA-activated currents showed pronounced outward rectification for both cell
types (when the main cations are Na+ in the bath and Cs+ in the pipette solution).
The current reversed close to 0 mV and the ratio of chord conductances 80 mV on
either side of the reversal potential was 2.66 for KA-activated currents in CA3
cell patches and 2.60 in CA1 cell patches. AMPA-activated currents showed a time-dependent
increase after steps to positive membrane potentials and a decrease after steps
to negative voltages, indicating that a gating process is responsible for outward
rectification of the steady-state I-IV. 5. The permeability (P) of GluR channels
was high for Na+ as compared to Cs+ for both cell types (P(Na)/P(Cs) = 0.88 and
0.84). The permeability was low for N-methyl-D-glucamine+ (P(NMG)/P(Cs) ≤ 0.03)
and Ca2+ (P(Ca)/P(Cs) ≤0.05). 6. The current noise level increased during application
of AMPA or KA. Apparent single-channel conductances obtained from fluctuation
analysis were higher for AMPA than for KA, but similar for both cell types. In
CA3 cell patches, AMPA activated channels with an apparent chord conductance of
7.2 pS, KA of 3.0 pS conductance. 7. Fast agonist application revealed desensitization
of GluR channels which was dependent on the type of agonist, currents activated
by AMPA and L-Glu rose rapidly to a peak and then desensitized to a steady-state
current. In contrast, currents activated by fast application of KA rose to a plateau
and did not desensitize. The steady state current expressed as a percentage of
the peak current was higher for L-Glu than for AMPA and slightly higher for CA3
than for CA1 cell patches. For CA3 cell patches, this fraction amounted to 6.2
%, with 300 μM-L-Glu and 2.8%, with 300 μM-AMPA. For CA1 cell patches, corresponding
values were 3.6 and 1.9 % 8. The dose response relations for the peak current
activated by AMPA and L-Glu and the steady-state current activated by KA were
similar for CA3 and CA1 cell patches. The order of potency was AMPA > L-Glu
≃ KA for both cell types EC50 values 189, 342 and 344 μM for CA3 cell patches
and 183, 424 and 474 μM for CA1 cell patches). In all cases, the Hill coefficients
ranged between 12 and 1.7. 8. The rise of AMPA and L-Glu-activated currents became
faster with increasing agonist concentration for both cell types. With L-Glu,
rise times decreased from about 3 ms at 100 μM to 500 μs at 3 mM. The delay for
agonist concentrations ≥ 300 μM was described by the sum of two exponential functions.
The time constant of the predominant fast component was slightly concentration
dependent and decreased from about 12 ms at 300 μM to 8 ms at 3 mM-L-Glu. 10.
The current voltage relations of the peak currents activated by 300 μM-AMPA were
linear for both cell types with a reversal potential close to OmV. 11. It is concluded
that the GluR channels in pyramidal cells of hippocampal CA3 and CA1 regions are
distinet but share many pharmacological and functional properties. Comparison
of the properties of native and recombinant GluRs suggests that in both CA3 and
CA1 regions GluR channels are hetero-oligomers containing the GluR-B subunit.
acknowledgement: "We thank Dr D. Colquhoun, Dr J. P. Ruppersberg and Dr T. A. Verdoorn
for critically reading the manuscript, K. Bauer, C. Busch and F. Helmchen for computer
programming, and M. Kaiser for technical assistance. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Jonas PM, Sakmann B. Glutamate receptor channels in isolated patches from CA1
and CA3 pyramidal cells of rat hippocampal slices. Journal of Physiology.
1992;455:143-171. doi:10.1113/jphysiol.1992.sp019294
apa: Jonas, P. M., & Sakmann, B. (1992). Glutamate receptor channels in isolated
patches from CA1 and CA3 pyramidal cells of rat hippocampal slices. Journal
of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1992.sp019294
chicago: Jonas, Peter M, and Bert Sakmann. “Glutamate Receptor Channels in Isolated
Patches from CA1 and CA3 Pyramidal Cells of Rat Hippocampal Slices.” Journal
of Physiology. Wiley-Blackwell, 1992. https://doi.org/10.1113/jphysiol.1992.sp019294 .
ieee: P. M. Jonas and B. Sakmann, “Glutamate receptor channels in isolated patches
from CA1 and CA3 pyramidal cells of rat hippocampal slices,” Journal of Physiology,
vol. 455. Wiley-Blackwell, pp. 143–171, 1992.
ista: Jonas PM, Sakmann B. 1992. Glutamate receptor channels in isolated patches
from CA1 and CA3 pyramidal cells of rat hippocampal slices. Journal of Physiology.
455, 143–171.
mla: Jonas, Peter M., and Bert Sakmann. “Glutamate Receptor Channels in Isolated
Patches from CA1 and CA3 Pyramidal Cells of Rat Hippocampal Slices.” Journal
of Physiology, vol. 455, Wiley-Blackwell, 1992, pp. 143–71, doi:10.1113/jphysiol.1992.sp019294 .
short: P.M. Jonas, B. Sakmann, Journal of Physiology 455 (1992) 143–171.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-09-01T00:00:00Z
date_updated: 2022-03-16T13:01:55Z
day: '01'
doi: '10.1113/jphysiol.1992.sp019294 '
extern: '1'
external_id:
pmid:
- '1282929 '
intvolume: ' 455'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.1992.sp019294
month: '09'
oa: 1
oa_version: Published Version
page: 143 - 171
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2917'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal
cells of rat hippocampal slices
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 455
year: '1992'
...
---
_id: '3471'
abstract:
- lang: eng
text: 1. Outside-out patches were isolated from granule cells of dentate gyrus and
pyramidal cells of CA3 and CA1 regions of rat hippocampal slices. Patches were
exposed briefly to L-glutamate using a piezo-driven double-barrelled application
pipette. 2. Applications of glutamate (1 mM) of 1 ms duration activated patch
currents which rose and decayed rapidly. The 20-80% rise time of these glutamate
receptor (GluR)-mediated currents was usually 0.2-0.6 ms. At -50 mV the peak current
varied from 10 to 500 pA in different patches. 3. The peak current-voltage relation
for brief pulses of 1 mM glutamate was virtually linear in normal extracellular
solution for patches from the three cell types (-100 to 60 mV). 4. The permeability
of GluR channels activated at the peak to Ca2+, relative to K+, was less than
0.1 for all three cell types (under bi-ionic conditions with Ca2+ on the extracellular
side and K+ on the intracellular side of the membrane). 5. The offset decay time
constant of the current following 1 ms pulses of 1 mM glutamate was brief, with
mean values of 3.0 +/- 0.8, 2.5 +/- 0.7, and 2.3 +/- 0.7 ms for dentate, CA3 and
CA1 cell patches, respectively. Offset time constants were independent of membrane
potential and independent of glutamate concentration (200 microM and 1 mM) for
the three cell types. 6. Applications of 1 mM glutamate of 100 ms duration showed
that glutamate responses desensitized rapidly. The time constants for desensitization
were 9.4 +/- 2.7, 11.3 +/- 2.8, and 9.3 +/- 2.8 ms for patches from dentate, CA3
and CA1 cells respectively. Desensitization time constants were only weakly dependent
on glutamate concentration (200 microM and 1 mM) for the three cell types. Thus
offset time constants are about four times faster than desensitization time constants
for both glutamate concentrations. 7. Double pulse application of glutamate indicated
that even a 1 ms pulse of 1 mM glutamate causes partial (about 60%) desensitization
of GluR channels. The time course of recovery from desensitization was slower
in dentate gyrus granule cell patches than in CA3 or CA1 pyramidal cell patches.
8. Desensitization was studied at equilibrium by exposing patches to low glutamate
concentrations for at least 15 s before a 1 ms test pulse of 1 mM glutamate.
acknowledgement: 'We thank Drs N.Burnashev, P. Ruppersberg , and G.Stuart for critically
reading the manuscript, and Marlies Kaiser for technical assistance. D.C.is a recipient
of a Humboldt prize. '
article_processing_charge: No
article_type: original
author:
- first_name: D.
full_name: Colquhoun, D.
last_name: Colquhoun
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Colquhoun D, Jonas PM, Sakmann B. Action of brief pulses of glutamate on AMPA/kainate
receptors in patches from different neurones of rat hippocampal slices. Journal
of Physiology. 1992;458:261-287. doi:10.1113/jphysiol.1992.sp019417
apa: Colquhoun, D., Jonas, P. M., & Sakmann, B. (1992). Action of brief pulses
of glutamate on AMPA/kainate receptors in patches from different neurones of rat
hippocampal slices. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1992.sp019417
chicago: Colquhoun, D., Peter M Jonas, and Bert Sakmann. “Action of Brief Pulses
of Glutamate on AMPA/Kainate Receptors in Patches from Different Neurones of Rat
Hippocampal Slices.” Journal of Physiology. Wiley-Blackwell, 1992. https://doi.org/10.1113/jphysiol.1992.sp019417.
ieee: D. Colquhoun, P. M. Jonas, and B. Sakmann, “Action of brief pulses of glutamate
on AMPA/kainate receptors in patches from different neurones of rat hippocampal
slices,” Journal of Physiology, vol. 458. Wiley-Blackwell, pp. 261–287,
1992.
ista: Colquhoun D, Jonas PM, Sakmann B. 1992. Action of brief pulses of glutamate
on AMPA/kainate receptors in patches from different neurones of rat hippocampal
slices. Journal of Physiology. 458, 261–287.
mla: Colquhoun, D., et al. “Action of Brief Pulses of Glutamate on AMPA/Kainate
Receptors in Patches from Different Neurones of Rat Hippocampal Slices.” Journal
of Physiology, vol. 458, Wiley-Blackwell, 1992, pp. 261–87, doi:10.1113/jphysiol.1992.sp019417.
short: D. Colquhoun, P.M. Jonas, B. Sakmann, Journal of Physiology 458 (1992) 261–287.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-12-01T00:00:00Z
date_updated: 2022-03-16T12:41:01Z
day: '01'
doi: 10.1113/jphysiol.1992.sp019417
extern: '1'
external_id:
pmid:
- '1338788'
intvolume: ' 458'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175155/
month: '12'
oa: 1
oa_version: Published Version
page: 261 - 287
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2916'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Action of brief pulses of glutamate on AMPA/kainate receptors in patches from
different neurones of rat hippocampal slices
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 458
year: '1992'
...
---
_id: '3581'
abstract:
- lang: eng
text: 'A number of rendering algorithms in computer graphics sort three-dimensional
objects by depth and assume that there is no cycle that makes the sorting impossible.
One way to resolve the problem caused by cycles is to cut the objects into smaller
pieces. In this paper we address the problem of estimating how many such cuts
arc always sufficient. We also consider a few related algorithmic and combinatorial
geometry problems. For example, we demonstrate that n lines in space can be sorted
in randomized expected time O(n4’st’), provided that they define no cycle. We
also prove an 0(n7’4) upper bound on the number of points in space so that there
are n lines with the property that for each point there are at least three noncoplanar
lines that contain it. '
acknowledgement: "* Bernard Chazelle wishes to acknowledge the National Science Foundation
for supporting this research in part under Grant CCR-9002352. Herbert Edelsbrunner
acknowledges the support of the National Science Foundation under grants CCR-8714565
and CCR-8921421. Richard Pollack was supported in part by NSF grant CCR-8901484,
NSA grant MDA904-89-H-2030, and DIMACS, a Science and Technology Center under NSF
grant STC88-09648. Raimund Seidel acknowledges support by NSF grant CCR-8809040.
Mich Sharir was partially supported by the Office of Naval\r\nResearch under Grant
N00014-87-K-0129, by the National Science Foundation under Grant CCR-89-01484, and
by grants from the U.S.-Israeli Binational Science Foundation and the Fund for Basic
Research administered by the Israeli Academy of Sciences."
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Richard
full_name: Pollack, Richard
last_name: Pollack
- first_name: Raimund
full_name: Seidel, Raimund
last_name: Seidel
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
- first_name: Jack
full_name: Snoeyink, Jack
last_name: Snoeyink
citation:
ama: 'Chazelle B, Edelsbrunner H, Guibas L, et al. Counting and cutting cycles of
lines and rods in space. Computational Geometry: Theory and Applications.
1992;1(6):305-323. doi:10.1016/0925-7721(92)90009-H'
apa: 'Chazelle, B., Edelsbrunner, H., Guibas, L., Pollack, R., Seidel, R., Sharir,
M., & Snoeyink, J. (1992). Counting and cutting cycles of lines and rods in
space. Computational Geometry: Theory and Applications. Elsevier. https://doi.org/10.1016/0925-7721(92)90009-H'
chicago: 'Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, Richard Pollack,
Raimund Seidel, Micha Sharir, and Jack Snoeyink. “Counting and Cutting Cycles
of Lines and Rods in Space.” Computational Geometry: Theory and Applications.
Elsevier, 1992. https://doi.org/10.1016/0925-7721(92)90009-H.'
ieee: 'B. Chazelle et al., “Counting and cutting cycles of lines and rods
in space,” Computational Geometry: Theory and Applications, vol. 1, no.
6. Elsevier, pp. 305–323, 1992.'
ista: 'Chazelle B, Edelsbrunner H, Guibas L, Pollack R, Seidel R, Sharir M, Snoeyink
J. 1992. Counting and cutting cycles of lines and rods in space. Computational
Geometry: Theory and Applications. 1(6), 305–323.'
mla: 'Chazelle, Bernard, et al. “Counting and Cutting Cycles of Lines and Rods in
Space.” Computational Geometry: Theory and Applications, vol. 1, no. 6,
Elsevier, 1992, pp. 305–23, doi:10.1016/0925-7721(92)90009-H.'
short: 'B. Chazelle, H. Edelsbrunner, L. Guibas, R. Pollack, R. Seidel, M. Sharir,
J. Snoeyink, Computational Geometry: Theory and Applications 1 (1992) 305–323.'
date_created: 2018-12-11T12:04:04Z
date_published: 1992-06-01T00:00:00Z
date_updated: 2022-03-16T10:41:58Z
day: '01'
doi: 10.1016/0925-7721(92)90009-H
extern: '1'
intvolume: ' 1'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/092577219290009H?via%3Dihub
month: '06'
oa: 1
oa_version: Published Version
page: 305 - 323
publication: 'Computational Geometry: Theory and Applications'
publication_identifier:
issn:
- 0925-7721
publication_status: published
publisher: Elsevier
publist_id: '2804'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Counting and cutting cycles of lines and rods in space
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1
year: '1992'
...
---
_id: '4047'
abstract:
- lang: eng
text: Arrangements of curves in the plane are fundamental to many problems in computational
and combinatorial geometry (e.g. motion planning, algebraic cell decomposition,
etc.). In this paper we study various topological and combinatorial properties
of such arrangements under some mild assumptions on the shape of the curves, and
develop basic tools for the construction, manipulation, and analysis of these
arrangements. Our main results include a generalization of the zone theorem of
Edelsbrunner (1986) and Chazelle (1985) to arrangements of curves (in which we
show that the combinatorial complexity of the zone of a curve is nearly linear
in the number of curves) and an application of that theorem to obtain a nearly
quadratic incremental algorithm for the construction of such arrangements.
acknowledgement: 'Work on this paper by the first author has been supported by the
National Science Foundation under grant CCR-8714565. Work by the third and sixth
authors has been supported by Office of Naval Research Grant NOOOl4-82-K-0381, by
National Science Foundation Grant No. NSF-DCR-83-20085, by grants from the Digital
Equipment Corporation, and the IBM Corporation. Work by the sixth author has also
been supported by a research grant from the NCRD- the Israeli National Council for
Research and Development. Work by the fourth author has been supported by National
Science Foundation Grant DMS-8501947. '
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: János
full_name: Pach, János
last_name: Pach
- first_name: Richard
full_name: Pollack, Richard
last_name: Pollack
- first_name: Raimund
full_name: Seidel, Raimund
last_name: Seidel
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Edelsbrunner H, Guibas L, Pach J, Pollack R, Seidel R, Sharir M. Arrangements
of curves in the plane - topology, combinatorics, and algorithms. Theoretical
Computer Science. 1992;92(2):319-336. doi:10.1016/0304-3975(92)90319-B
apa: Edelsbrunner, H., Guibas, L., Pach, J., Pollack, R., Seidel, R., & Sharir,
M. (1992). Arrangements of curves in the plane - topology, combinatorics, and
algorithms. Theoretical Computer Science. Elsevier. https://doi.org/10.1016/0304-3975(92)90319-B
chicago: Edelsbrunner, Herbert, Leonidas Guibas, János Pach, Richard Pollack, Raimund
Seidel, and Micha Sharir. “Arrangements of Curves in the Plane - Topology, Combinatorics,
and Algorithms.” Theoretical Computer Science. Elsevier, 1992. https://doi.org/10.1016/0304-3975(92)90319-B.
ieee: H. Edelsbrunner, L. Guibas, J. Pach, R. Pollack, R. Seidel, and M. Sharir,
“Arrangements of curves in the plane - topology, combinatorics, and algorithms,”
Theoretical Computer Science, vol. 92, no. 2. Elsevier, pp. 319–336, 1992.
ista: Edelsbrunner H, Guibas L, Pach J, Pollack R, Seidel R, Sharir M. 1992. Arrangements
of curves in the plane - topology, combinatorics, and algorithms. Theoretical
Computer Science. 92(2), 319–336.
mla: Edelsbrunner, Herbert, et al. “Arrangements of Curves in the Plane - Topology,
Combinatorics, and Algorithms.” Theoretical Computer Science, vol. 92,
no. 2, Elsevier, 1992, pp. 319–36, doi:10.1016/0304-3975(92)90319-B.
short: H. Edelsbrunner, L. Guibas, J. Pach, R. Pollack, R. Seidel, M. Sharir, Theoretical
Computer Science 92 (1992) 319–336.
date_created: 2018-12-11T12:06:37Z
date_published: 1992-01-20T00:00:00Z
date_updated: 2022-03-16T09:04:37Z
day: '20'
doi: 10.1016/0304-3975(92)90319-B
extern: '1'
intvolume: ' 92'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/030439759290319B?via%3Dihub
month: '01'
oa: 1
oa_version: Published Version
page: 319 - 336
publication: Theoretical Computer Science
publication_identifier:
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
publist_id: '2079'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arrangements of curves in the plane - topology, combinatorics, and algorithms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 92
year: '1992'
...
---
_id: '2533'
abstract:
- lang: eng
text: A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated
through polymerase chain reaction-mediated DNA amplification by using primer sequences
conserved among the metabotropic glutamate receptor (mGluR) family and by the
subsequent screening of a rat brain cDNA library. The cloned receptor consists
of 1171 amino acid residues and exhibits a structural architecture common to the
mGluR family, possessing a large extracellular domain preceding the seven putative
membrane-spanning segments. mGluR5 shows the highest sequence similarity to mGluR1
among the mGluR members and is coupled to the stimulation of phosphatidylinositol
hydrolysis/ Ca2+ signal transduction in Chinese hamster ovary cells transfected
with the cloned cDNA. This receptor also resembles mGluR1 in its agonist selectivity
and antagonist responses; the potency rank order of agonists for mGluR5 was determined
to be quisqualate > L-glutamate ≥ ibotenate > trans-1-aminocyclopentane-1,3-dicarboxylate.
Blot and in situ hybridization analyses indicated that mGluR5 mRNA is widely distributed
in neuronal cells of the central nervous system and is expressed differently from
mGluR1 mRNA in many brain regions. This investigation thus demonstrates that there
is an additional mGluR subtype which closely resembles mGluR1 in its signal transduction
and pharmacological properties and is expressed in specialized neuronal cells
in the central nervous system.
acknowledgement: We are grateful to Seiji Ito for help of Ca2+ measurements and Akira
Uesugi for photographic assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Hidemitsu
full_name: Sugihara, Hidemitsu
last_name: Sugihara
- first_name: Hiroyuki
full_name: Nawa, Hiroyuki
last_name: Nawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization
of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+
signal transduction. Journal of Biological Chemistry. 1992;267(19):13361-13368.
doi:10.1016/S0021-9258(18)42219-3
apa: Abe, T., Sugihara, H., Nawa, H., Shigemoto, R., Mizuno, N., & Nakanishi,
S. (1992). Molecular characterization of a novel metabotropic glutamate receptor
mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/S0021-9258(18)42219-3
chicago: Abe, Takaaki, Hidemitsu Sugihara, Hiroyuki Nawa, Ryuichi Shigemoto, Noboru
Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a Novel Metabotropic
Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.”
Journal of Biological Chemistry. American Society for Biochemistry and
Molecular Biology, 1992. https://doi.org/10.1016/S0021-9258(18)42219-3.
ieee: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Molecular
characterization of a novel metabotropic glutamate receptor mGluR5 coupled to
inositol phosphate/Ca2+ signal transduction,” Journal of Biological Chemistry,
vol. 267, no. 19. American Society for Biochemistry and Molecular Biology, pp.
13361–13368, 1992.
ista: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1992. Molecular
characterization of a novel metabotropic glutamate receptor mGluR5 coupled to
inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry.
267(19), 13361–13368.
mla: Abe, Takaaki, et al. “Molecular Characterization of a Novel Metabotropic Glutamate
Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” Journal
of Biological Chemistry, vol. 267, no. 19, American Society for Biochemistry
and Molecular Biology, 1992, pp. 13361–68, doi:10.1016/S0021-9258(18)42219-3.
short: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal
of Biological Chemistry 267 (1992) 13361–13368.
date_created: 2018-12-11T11:58:14Z
date_published: 1992-07-05T00:00:00Z
date_updated: 2022-03-17T15:08:29Z
day: '05'
doi: 10.1016/S0021-9258(18)42219-3
extern: '1'
external_id:
pmid:
- '1320017'
intvolume: ' 267'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925818422193
month: '07'
oa: 1
oa_version: Published Version
page: 13361 - 13368
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4366'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5
coupled to inositol phosphate/Ca2+ signal transduction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 267
year: '1992'
...
---
_id: '2535'
abstract:
- lang: eng
text: We report the molecular characterization of two novel rat helix-loop-helix
(HLH) proteins, designated HES-1 and HES-3, that show structural homology to the
Drosophila hairy and Enhancer of split [E(spl)] proteins, both of which are required
for normal neurogenesis. HES-1 mRNA, expressed in various tissues of both embryos
and adults, is present at a high level in the epithelial cells, including the
embryonal neuroepithelial cells, as well as in the mesoderm-derived tissues such
as the embryonal muscle. In contrast, HES-3 mRNA is produced exclusively in cerebellar
Purkinje cells. HES-1 represses transcription by binding to the N box, which is
a recognition sequence of E(spl) proteins. Interestingly, neither HES-1 nor HES-3
alone interacts efficiently with the E box, but each protein decreases the transcription
induced by E-box-binding HLH activators such as E47. Furthermore, HES-1 also inhibits
the functions of MyoD and MASH1 and effectively diminishes the myogenic conversion
of C3H10T1/2 cells induced by MyoD. These results suggest that HES-1 may play
an important role in mammalian development by negatively acting on the two different
sequences while HES-3 acts as a repressor in a specific type of neurons.
acknowledgement: "We thank Professor Noboru Mizuno for his kind help with in situ
hybridization experiments, Akira Uesugi and Dr. Chihiro\r\nAkazawa for photographic
assistance, Drs. Elizabeth Knust and Jose A. Campos-Ortega for communicating their
unpublished results, Dr. Shinji Fushiki for useful discussion, Dr. Mikio Nishizawa
and Professor Shigekazu Nagata for pMNT, Dr. David Baltimore for the E47 expression
vector, Drs. Yoichiro Nabeshima and Atsuko Fujisawa for the MyoD expression vector
and the reporter plasmid with the MCK enhancer, and Dr. Makoto Ishibashi for his
help in isolating the human E47 eDNA clone. This work was supported in part by research
grants from the Ministry of Education, Science, and Culture of Japan. The publication
costs of this article were defrayed in part by payment of page charges. This article
must therefore be hereby marked \"advertisement\" in accordance with 18 USC section
1734 solely to indicate this fact. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Yoshiki
full_name: Sasai, Yoshiki
last_name: Sasai
- first_name: Ryoichiro
full_name: Kageyama, Ryoichiro
last_name: Kageyama
- first_name: Yoshiaki
full_name: Tagawa, Yoshiaki
last_name: Tagawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix
factors structurally related to Drosophila hairy and Enhancer of split. Genes
and Development. 1992;6(12 B):2620-2634. doi:10.1101/gad.6.12b.2620
apa: Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R., & Nakanishi, S. (1992).
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy
and Enhancer of split. Genes and Development. Cold Spring Harbor Laboratory
Press. https://doi.org/10.1101/gad.6.12b.2620
chicago: Sasai, Yoshiki, Ryoichiro Kageyama, Yoshiaki Tagawa, Ryuichi Shigemoto,
and Shigetada Nakanishi. “Two Mammalian Helix-Loop-Helix Factors Structurally
Related to Drosophila Hairy and Enhancer of Split.” Genes and Development.
Cold Spring Harbor Laboratory Press, 1992. https://doi.org/10.1101/gad.6.12b.2620.
ieee: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, and S. Nakanishi, “Two mammalian
helix-loop-helix factors structurally related to Drosophila hairy and Enhancer
of split,” Genes and Development, vol. 6, no. 12 B. Cold Spring Harbor
Laboratory Press, pp. 2620–2634, 1992.
ista: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. 1992. Two mammalian
helix-loop-helix factors structurally related to Drosophila hairy and Enhancer
of split. Genes and Development. 6(12 B), 2620–2634.
mla: Sasai, Yoshiki, et al. “Two Mammalian Helix-Loop-Helix Factors Structurally
Related to Drosophila Hairy and Enhancer of Split.” Genes and Development,
vol. 6, no. 12 B, Cold Spring Harbor Laboratory Press, 1992, pp. 2620–34, doi:10.1101/gad.6.12b.2620.
short: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, S. Nakanishi, Genes and Development
6 (1992) 2620–2634.
date_created: 2018-12-11T11:58:15Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-17T14:52:29Z
day: '01'
doi: 10.1101/gad.6.12b.2620
extern: '1'
external_id:
pmid:
- '1340473'
intvolume: ' 6'
issue: 12 B
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://genesdev.cshlp.org/content/6/12b/2620
month: '01'
oa: 1
oa_version: Published Version
page: 2620 - 2634
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '4364'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Two mammalian helix-loop-helix factors structurally related to Drosophila hairy
and Enhancer of split
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1992'
...
---
_id: '2722'
abstract:
- lang: eng
text: 'A version of the one-dimensional Rayleigh gas is considered: a point particle
of mass M (molecule), confined to the unit interval [0,1], is surrounded by an
infinite ideal gas of point particles of mass 1 (atoms). The molecule interacts
with the atoms and with the walls via elastic collision. Central limit theorems
are proved for a wide class of additive functionals of this system (e.g. the number
of collisions with the walls and the total length of the molecular path).'
acknowledgement: "The authors are very grateful to D. Szasz and A. Kramli for valuable
discussions and their encouragement. We are also indebted to D. Dϋrr for his comments
and suggestions.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Dao
full_name: Tuyen, Dao
last_name: Tuyen
citation:
ama: Erdös L, Tuyen D. Central limit theorems for the one-dimensional Rayleigh gas
with semipermeable barriers. Communications in Mathematical Physics. 1992;143(3):451-466.
doi:10.1007/BF02099260
apa: Erdös, L., & Tuyen, D. (1992). Central limit theorems for the one-dimensional
Rayleigh gas with semipermeable barriers. Communications in Mathematical Physics.
Springer. https://doi.org/10.1007/BF02099260
chicago: Erdös, László, and Dao Tuyen. “Central Limit Theorems for the One-Dimensional
Rayleigh Gas with Semipermeable Barriers.” Communications in Mathematical Physics.
Springer, 1992. https://doi.org/10.1007/BF02099260.
ieee: L. Erdös and D. Tuyen, “Central limit theorems for the one-dimensional Rayleigh
gas with semipermeable barriers,” Communications in Mathematical Physics,
vol. 143, no. 3. Springer, pp. 451–466, 1992.
ista: Erdös L, Tuyen D. 1992. Central limit theorems for the one-dimensional Rayleigh
gas with semipermeable barriers. Communications in Mathematical Physics. 143(3),
451–466.
mla: Erdös, László, and Dao Tuyen. “Central Limit Theorems for the One-Dimensional
Rayleigh Gas with Semipermeable Barriers.” Communications in Mathematical Physics,
vol. 143, no. 3, Springer, 1992, pp. 451–66, doi:10.1007/BF02099260.
short: L. Erdös, D. Tuyen, Communications in Mathematical Physics 143 (1992) 451–466.
date_created: 2018-12-11T11:59:15Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-16T14:24:12Z
day: '01'
doi: 10.1007/BF02099260
extern: '1'
intvolume: ' 143'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://projecteuclid.org/journals/communications-in-mathematical-physics/volume-143/issue-3/Central-limit-theorems-for-the-one-dimensional-Rayleigh-gas-with/cmp/1104249076.full
month: '01'
oa: 1
oa_version: Published Version
page: 451 - 466
publication: Communications in Mathematical Physics
publication_identifier:
issn:
- 0010-3616
publication_status: published
publisher: Springer
publist_id: '4170'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Central limit theorems for the one-dimensional Rayleigh gas with semipermeable
barriers
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 143
year: '1992'
...
---
_id: '4052'
abstract:
- lang: eng
text: This paper describes an effective procedure for stratifying a real semi-algebraic
set into cells of constant description size. The attractive feature of our method
is that the number of cells produced is singly exponential in the number of input
variables. This compares favorably with the doubly exponential size of Collins'
decomposition. Unlike Collins' construction, however, our scheme does not produce
a cell complex but only a smooth stratification. Nevertheless, we are able to
apply our results in interesting ways to problems of point location and geometric
optimization.
acknowledgement: The authors wish to thank DEC/Systems Research Center and DEC/Paris
Research Laboratory, where part of this research was conducted. For individual support,
Bernard Chazelle acknowledges the National Science Foundation for supporting this
research in part under Grant CCR-8700917. Herbert Edelsbrunner acknowledges the
support of the National Science Foundation under Grant CCR-8714565. Micha Sharir
acknowledges the Office of Naval Research under Grant N00014-87-K-0129, the National
Science Foundation under Grant No. NSF-DCR-83-20085, grants from the Digital Equipment
Corporation and the IBM Corporation, and a research grant from the US-Israeli Binational
Science Foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Chazelle B, Edelsbrunner H, Guibas L, Sharir M. A singly exponential stratification
scheme for real semi-algebraic varieties and its applications. Theoretical
Computer Science. 1991;84(1):77-105. doi:10.1016/0304-3975(91)90261-Y
apa: Chazelle, B., Edelsbrunner, H., Guibas, L., & Sharir, M. (1991). A singly
exponential stratification scheme for real semi-algebraic varieties and its applications.
Theoretical Computer Science. Elsevier. https://doi.org/10.1016/0304-3975(91)90261-Y
chicago: Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, and Micha Sharir.
“A Singly Exponential Stratification Scheme for Real Semi-Algebraic Varieties
and Its Applications.” Theoretical Computer Science. Elsevier, 1991. https://doi.org/10.1016/0304-3975(91)90261-Y.
ieee: B. Chazelle, H. Edelsbrunner, L. Guibas, and M. Sharir, “A singly exponential
stratification scheme for real semi-algebraic varieties and its applications,”
Theoretical Computer Science, vol. 84, no. 1. Elsevier, pp. 77–105, 1991.
ista: Chazelle B, Edelsbrunner H, Guibas L, Sharir M. 1991. A singly exponential
stratification scheme for real semi-algebraic varieties and its applications.
Theoretical Computer Science. 84(1), 77–105.
mla: Chazelle, Bernard, et al. “A Singly Exponential Stratification Scheme for Real
Semi-Algebraic Varieties and Its Applications.” Theoretical Computer Science,
vol. 84, no. 1, Elsevier, 1991, pp. 77–105, doi:10.1016/0304-3975(91)90261-Y.
short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, Theoretical Computer
Science 84 (1991) 77–105.
date_created: 2018-12-11T12:06:39Z
date_published: 1991-07-22T00:00:00Z
date_updated: 2022-03-02T10:23:58Z
day: '22'
doi: 10.1016/0304-3975(91)90261-Y
extern: '1'
intvolume: ' 84'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/030439759190261Y?via%3Dihub
month: '07'
oa: 1
oa_version: Published Version
page: 77 - 105
publication: Theoretical Computer Science
publication_identifier:
eissn:
- 1879-2294
issn:
- 0304-3975
publication_status: published
publisher: Elsevier
publist_id: '2073'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A singly exponential stratification scheme for real semi-algebraic varieties
and its applications
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '1991'
...
---
_id: '4056'
abstract:
- lang: eng
text: This paper proves that for every n ≥ 4 there is a convex n-gon such that the
vertices of 2n - 7 vertex pairs are one unit of distance apart. This improves
the previously best lower bound of ⌊ (5n - 5) 3⌋ given by Erdo{combining double
acute accent}s and Moser if n ≥ 17.
acknowledgement: The first author is pleased to acknowledge partial support by the
Amoco Fnd. Fat. Dev. Comput. Sci. i-6-44862 and the National Science Foundation
under Grant CCR-8714565.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Péter
full_name: Hajnal, Péter
last_name: Hajnal
citation:
ama: Edelsbrunner H, Hajnal P. A lower bound on the number of unit distances between
the vertices of a convex polygon. Journal of Combinatorial Theory Series A.
1991;56(2):312-316. doi:10.1016/0097-3165(91)90042-F
apa: Edelsbrunner, H., & Hajnal, P. (1991). A lower bound on the number of unit
distances between the vertices of a convex polygon. Journal of Combinatorial
Theory Series A. Elsevier. https://doi.org/10.1016/0097-3165(91)90042-F
chicago: Edelsbrunner, Herbert, and Péter Hajnal. “A Lower Bound on the Number of
Unit Distances between the Vertices of a Convex Polygon.” Journal of Combinatorial
Theory Series A. Elsevier, 1991. https://doi.org/10.1016/0097-3165(91)90042-F.
ieee: H. Edelsbrunner and P. Hajnal, “A lower bound on the number of unit distances
between the vertices of a convex polygon,” Journal of Combinatorial Theory
Series A, vol. 56, no. 2. Elsevier, pp. 312–316, 1991.
ista: Edelsbrunner H, Hajnal P. 1991. A lower bound on the number of unit distances
between the vertices of a convex polygon. Journal of Combinatorial Theory Series
A. 56(2), 312–316.
mla: Edelsbrunner, Herbert, and Péter Hajnal. “A Lower Bound on the Number of Unit
Distances between the Vertices of a Convex Polygon.” Journal of Combinatorial
Theory Series A, vol. 56, no. 2, Elsevier, 1991, pp. 312–16, doi:10.1016/0097-3165(91)90042-F.
short: H. Edelsbrunner, P. Hajnal, Journal of Combinatorial Theory Series A 56 (1991)
312–316.
date_created: 2018-12-11T12:06:41Z
date_published: 1991-03-01T00:00:00Z
date_updated: 2022-03-02T09:56:10Z
day: '01'
doi: 10.1016/0097-3165(91)90042-F
extern: '1'
intvolume: ' 56'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/009731659190042F?via%3Dihub
month: '03'
oa: 1
oa_version: Published Version
page: 312 - 316
publication: Journal of Combinatorial Theory Series A
publication_identifier:
eissn:
- 1096-0899
issn:
- 0097-3165
publication_status: published
publisher: Elsevier
publist_id: '2070'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A lower bound on the number of unit distances between the vertices of a convex
polygon
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 56
year: '1991'
...
---
_id: '4057'
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Edelsbrunner H. Corrigendum. Journal of Computer and System Sciences.
1991;42(2):249-251. doi:10.1016/0022-0000(91)90013-U
apa: Edelsbrunner, H. (1991). Corrigendum. Journal of Computer and System Sciences.
Elsevier. https://doi.org/10.1016/0022-0000(91)90013-U
chicago: Edelsbrunner, Herbert. “Corrigendum.” Journal of Computer and System
Sciences. Elsevier, 1991. https://doi.org/10.1016/0022-0000(91)90013-U.
ieee: H. Edelsbrunner, “Corrigendum,” Journal of Computer and System Sciences,
vol. 42, no. 2. Elsevier, pp. 249–251, 1991.
ista: Edelsbrunner H. 1991. Corrigendum. Journal of Computer and System Sciences.
42(2), 249–251.
mla: Edelsbrunner, Herbert. “Corrigendum.” Journal of Computer and System Sciences,
vol. 42, no. 2, Elsevier, 1991, pp. 249–51, doi:10.1016/0022-0000(91)90013-U.
short: H. Edelsbrunner, Journal of Computer and System Sciences 42 (1991) 249–251.
date_created: 2018-12-11T12:06:41Z
date_published: 1991-04-01T00:00:00Z
date_updated: 2022-03-02T10:06:55Z
day: '01'
doi: 10.1016/0022-0000(91)90013-U
extern: '1'
intvolume: ' 42'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/002200009190013U?via%3Dihub
month: '04'
oa: 1
oa_version: Published Version
page: 249 - 251
publication: Journal of Computer and System Sciences
publication_identifier:
eissn:
- 1090-2724
issn:
- 0022-0000
publication_status: published
publisher: Elsevier
publist_id: '2071'
quality_controlled: '1'
status: public
title: Corrigendum
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 42
year: '1991'
...
---
_id: '4061'
abstract:
- lang: eng
text: We present an algorithm to compute a Euclidean minimum spanning tree of a
given set S of N points in Ed in time O(Fd (N,N) logd N), where Fd (n,m) is the
time required to compute a bichromatic closest pair among n red and m green points
in Ed . If Fd (N,N)=Ω(N1+ε), for some fixed e{open}>0, then the running time
improves to O(Fd (N,N)). Furthermore, we describe a randomized algorithm to compute
a bichromatic closest pair in expected time O((nm log n log m)2/3+m log2 n+n log2
m) in E3, which yields an O(N4/3 log4/3 N) expected time, algorithm for computing
a Euclidean minimum spanning tree of N points in E3. In d≥4 dimensions we obtain
expected time O((nm)1-1/([d/2]+1)+ε+m log n+n log m) for the bichromatic closest
pair problem and O(N2-2/([d/2]+1)ε) for the Euclidean minimum spanning tree problem,
for any positive e{open}.
acknowledgement: The first, second, and fourth authors acknowledge support from the
Center for Discrete Mathematics and Theoretical Computer Science (DIMACS), a National
Science Foundation Science and Technology Center under NSF Grant STC 88-09648. The
second author's work was supported by the National Science Foundation under Grant
CCR-8714565. The third author's work was supported by the Deutsche Forschungsgemeinschaft
under Grant A1 253/1-3, Schwerpunktprogramm "Datenstrukturen und effiziente Algorithmen."
The last two authors' work was also partially supported by the ESPRIT II Basic Research
Action of the EC under Contract No. 3075 (project ALCOM).
article_processing_charge: No
article_type: original
author:
- first_name: Pankaj
full_name: Agarwal, Pankaj
last_name: Agarwal
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Otfried
full_name: Schwarzkopf, Otfried
last_name: Schwarzkopf
- first_name: Emo
full_name: Welzl, Emo
last_name: Welzl
citation:
ama: Agarwal P, Edelsbrunner H, Schwarzkopf O, Welzl E. Euclidean minimum spanning
trees and bichromatic closest pairs. Discrete & Computational Geometry.
1991;6(1):407-422. doi:10.1007/BF02574698
apa: Agarwal, P., Edelsbrunner, H., Schwarzkopf, O., & Welzl, E. (1991). Euclidean
minimum spanning trees and bichromatic closest pairs. Discrete & Computational
Geometry. Springer. https://doi.org/10.1007/BF02574698
chicago: Agarwal, Pankaj, Herbert Edelsbrunner, Otfried Schwarzkopf, and Emo Welzl.
“Euclidean Minimum Spanning Trees and Bichromatic Closest Pairs.” Discrete
& Computational Geometry. Springer, 1991. https://doi.org/10.1007/BF02574698.
ieee: P. Agarwal, H. Edelsbrunner, O. Schwarzkopf, and E. Welzl, “Euclidean minimum
spanning trees and bichromatic closest pairs,” Discrete & Computational
Geometry, vol. 6, no. 1. Springer, pp. 407–422, 1991.
ista: Agarwal P, Edelsbrunner H, Schwarzkopf O, Welzl E. 1991. Euclidean minimum
spanning trees and bichromatic closest pairs. Discrete & Computational Geometry.
6(1), 407–422.
mla: Agarwal, Pankaj, et al. “Euclidean Minimum Spanning Trees and Bichromatic Closest
Pairs.” Discrete & Computational Geometry, vol. 6, no. 1, Springer,
1991, pp. 407–22, doi:10.1007/BF02574698.
short: P. Agarwal, H. Edelsbrunner, O. Schwarzkopf, E. Welzl, Discrete & Computational
Geometry 6 (1991) 407–422.
date_created: 2018-12-11T12:06:42Z
date_published: 1991-12-01T00:00:00Z
date_updated: 2022-02-24T15:06:41Z
day: '01'
doi: 10.1007/BF02574698
extern: '1'
intvolume: ' 6'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://link.springer.com/article/10.1007/BF02574698
month: '12'
oa: 1
oa_version: Published Version
page: 407 - 422
publication: Discrete & Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2062'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Euclidean minimum spanning trees and bichromatic closest pairs
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1991'
...
---
_id: '4062'
abstract:
- lang: eng
text: We prove that for any set S of n points in the plane and n3-α triangles spanned
by the points in S there exists a point (not necessarily in S) contained in at
least n3-3α/(c log5 n) of the triangles. This implies that any set of n points
in three-dimensional space defines at most {Mathematical expression} halving planes.
acknowledgement: "Work on this paper by Boris Aronov and Rephael Wenger has been supported
by DIMACS under NSF Grant STC-88-09648. Work on this paper by Bernard Chazelle has
been supported by NSF Grant CCR-87-00917. Work by Herbert Edelsbrunner has been
supported by NSF Grant CCR-87-14565. Micha Sharir has been supported by ONR Grant
N00014-87-K-0129, by NSF Grant CCR-89-01484, and by grants from the U.S.-Israeli
Binational Science Foundation, the Israeli National Council for Research and Development,
and the Fund for Basic Research administered by the Israeli\r\nAcademy of Sciences"
article_processing_charge: No
article_type: original
author:
- first_name: Boris
full_name: Aronov, Boris
last_name: Aronov
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
- first_name: Rephael
full_name: Wenger, Rephael
last_name: Wenger
citation:
ama: Aronov B, Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Wenger R. Points
and triangles in the plane and halving planes in space. Discrete & Computational
Geometry. 1991;6(1):435-442. doi:10.1007/BF02574700
apa: Aronov, B., Chazelle, B., Edelsbrunner, H., Guibas, L., Sharir, M., & Wenger,
R. (1991). Points and triangles in the plane and halving planes in space. Discrete
& Computational Geometry. Springer. https://doi.org/10.1007/BF02574700
chicago: Aronov, Boris, Bernard Chazelle, Herbert Edelsbrunner, Leonidas Guibas,
Micha Sharir, and Rephael Wenger. “Points and Triangles in the Plane and Halving
Planes in Space.” Discrete & Computational Geometry. Springer, 1991.
https://doi.org/10.1007/BF02574700.
ieee: B. Aronov, B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, and R. Wenger,
“Points and triangles in the plane and halving planes in space,” Discrete &
Computational Geometry, vol. 6, no. 1. Springer, pp. 435–442, 1991.
ista: Aronov B, Chazelle B, Edelsbrunner H, Guibas L, Sharir M, Wenger R. 1991.
Points and triangles in the plane and halving planes in space. Discrete &
Computational Geometry. 6(1), 435–442.
mla: Aronov, Boris, et al. “Points and Triangles in the Plane and Halving Planes
in Space.” Discrete & Computational Geometry, vol. 6, no. 1, Springer,
1991, pp. 435–42, doi:10.1007/BF02574700.
short: B. Aronov, B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, R. Wenger,
Discrete & Computational Geometry 6 (1991) 435–442.
date_created: 2018-12-11T12:06:43Z
date_published: 1991-12-01T00:00:00Z
date_updated: 2022-02-24T15:39:25Z
day: '01'
doi: 10.1007/BF02574700
extern: '1'
intvolume: ' 6'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://link.springer.com/article/10.1007/BF02574700
month: '12'
oa: 1
oa_version: Published Version
page: 435 - 442
publication: Discrete & Computational Geometry
publication_identifier:
eissn:
- 1432-0444
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2063'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Points and triangles in the plane and halving planes in space
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1991'
...
---
_id: '3467'
abstract:
- lang: eng
text: The effects of mast cell degranulating peptide (MCDP), a toxin from the honey
bee, and of dendrotoxin (DTX), a toxin from the green mamba snake, were studied
in voltage-clamped experiments with myelinated nerve fibres of Xenopus. MCDP and
DTX blocked part of the K+ current. About 20% of the K+ current, however, was
resistant to the toxins even in high concentrations. In Ringer solution half-maximal
block was reached with concentrations of 33 nM MCDP and 11 nM DTX. In high-K+
solution the potency of both toxins was lower. β-Bungarotoxin (β-BuTX), another
snake toxin, also blocked part of the K+ current, but was less potent than MCDP
and DTX. Tail currents in high-K+ solution were analysed and three K+ current
components were separated according to Dubois (1981b). Both MCDP and DTX selectively
blocked a fast deactivating, slowly inactivating K+ current component which steeply
activates between E = -60 mV and E = -40 mV (component f1). In concentrations
around 100 nM, MCDP and DTX blocked neither the slow K+ current (component s)
nor the fast deactivating, rapidly inactivating K+ current which activates between
E = -40 mV and E = 20 mV (component f2). Similar results could be derived from
K+ outward currents in Ringer solution. In high-K+, IC50 of MCDP for component
f1 was 99 nM, whereas it was 7.6 μM for f2. Corresponding values for DTX are 68
nM and 1.8 μM. Binding studies with nerve fibre membranes of Xenopus reveal high-affinity
binding sites for 125I-labelled DTX )K(D) = 22 pM in Ringer solution and 81 pM
in high-K+ solution). 125I-labelled DTX can be displaced from its sites completely
by unlabelled DTX, toxin I (black mamba toxin), MCDP, and partially by β-BuTX.
Immunocytochemical staining demonstrates that binding sites for DTX are present
in nodal and paranodal regions of the axonal membrane. The axonal membrane of
motor and sensory nerve fibres is equipped with three types of well-characterized
K+ channels and constitutes so far the best preparation to study MCDP- and DTX-sensitive
K+ channels with electrophysiological and biochemical methods.
acknowledgement: "We thank Professor E. Habermann for critical reading of the manuscript
and E. Schmidt and J. Schafer for technical assistance. Financial support by the
Deutsche Forschungsgemeinschaft (Vo 188/13-1 and SFB 249) is gratefully acknowledged.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Bräu, Michael
last_name: Bräu
- first_name: Florian
full_name: Dreyer, Florian
last_name: Dreyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Holger
full_name: Repp, Holger
last_name: Repp
- first_name: Werner
full_name: Vogel, Werner
last_name: Vogel
citation:
ama: 'Bräu M, Dreyer F, Jonas PM, Repp H, Vogel W. A K+ channel in Xenopus nerve
fibres selectively blocked by bee and snake toxins: binding and voltage-clamp
experiments. Journal of Physiology. 1990;420:365-385. doi:10.1113/jphysiol.1990.sp017918'
apa: 'Bräu, M., Dreyer, F., Jonas, P. M., Repp, H., & Vogel, W. (1990). A K+
channel in Xenopus nerve fibres selectively blocked by bee and snake toxins: binding
and voltage-clamp experiments. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.1990.sp017918'
chicago: 'Bräu, Michael, Florian Dreyer, Peter M Jonas, Holger Repp, and Werner
Vogel. “A K+ Channel in Xenopus Nerve Fibres Selectively Blocked by Bee and Snake
Toxins: Binding and Voltage-Clamp Experiments.” Journal of Physiology.
Wiley-Blackwell, 1990. https://doi.org/10.1113/jphysiol.1990.sp017918.'
ieee: 'M. Bräu, F. Dreyer, P. M. Jonas, H. Repp, and W. Vogel, “A K+ channel in
Xenopus nerve fibres selectively blocked by bee and snake toxins: binding and
voltage-clamp experiments,” Journal of Physiology, vol. 420. Wiley-Blackwell,
pp. 365–385, 1990.'
ista: 'Bräu M, Dreyer F, Jonas PM, Repp H, Vogel W. 1990. A K+ channel in Xenopus
nerve fibres selectively blocked by bee and snake toxins: binding and voltage-clamp
experiments. Journal of Physiology. 420, 365–385.'
mla: 'Bräu, Michael, et al. “A K+ Channel in Xenopus Nerve Fibres Selectively Blocked
by Bee and Snake Toxins: Binding and Voltage-Clamp Experiments.” Journal of
Physiology, vol. 420, Wiley-Blackwell, 1990, pp. 365–85, doi:10.1113/jphysiol.1990.sp017918.'
short: M. Bräu, F. Dreyer, P.M. Jonas, H. Repp, W. Vogel, Journal of Physiology
420 (1990) 365–385.
date_created: 2018-12-11T12:03:29Z
date_published: 1990-01-01T00:00:00Z
date_updated: 2022-02-23T16:10:03Z
day: '01'
doi: 10.1113/jphysiol.1990.sp017918
extern: '1'
external_id:
pmid:
- '2324990'
intvolume: ' 420'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1190055/
month: '01'
oa: 1
oa_version: None
page: 365 - 385
pmid: 1
publication: Journal of Physiology
publication_identifier:
eissn:
- 1469-7793
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2920'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'A K+ channel in Xenopus nerve fibres selectively blocked by bee and snake
toxins: binding and voltage-clamp experiments'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 420
year: '1990'
...
---
_id: '3650'
abstract:
- lang: eng
text: Hybrid zones can yield estimates of natural selection and gene flow. The width
of a cline in gene frequency is approximately proportional to gene flow (σ) divided
by the square root of per-locus selection ( &s). Gene flow also causes gametic
correlations (linkage disequilibria) between genes that differ across hybrid zones.
Correlations are stronger when the hybrid zone is narrow, and rise to a maximum
roughly equal to s. Thus cline width and gametic correlations combine to give
estimates of gene flow and selection. These indirect measures of σ and s are especially
useful because they can be made from collections, and require no field experiments.
The method was applied to hybrid zones between color pattern races in a pair of
Peruvian Heliconius butterfly species. The species are Mullerian mimics of one
another, and both show the same changes in warning color pattern across their
respective hybrid zones. The expectations of cline width and gametic correlation
were generated using simulations of clines stabilized by strong frequency-dependent
selection. In the hybrid zone in Heliconius erato, clines at three major color
pattern loci were between 8.5 and 10.2 km wide, and the pairwise gametic correlations
peaked at R & 0.35. These measures suggest that s & 0.23 per locus, and
that σ & 2.6 km. In erato, the shapes of the clines agreed with that expected
on the basis of dominance. Heliconius melpomene has a nearly coincident hybrid
zone. In this species, cline widths at four major color pattern loci varied between
11.7 and 13.4 km. Pairwise gametic correlations peaked near R & 1.00 for tightly
linked genes, and at R & 0.40 for unlinked genes, giving s & 0.25 per
locus and σ & 3.7 km. In melpomene, cline shapes did not perfectly fit theoretical
shapes based on dominance; this deviation might be explained by long-distance
migration and/or strong epistasis. Compared with erato, sample sizes in melpomene
are lower and the genetics of its color patterns are less well understood. In
spite of these problems, selection and gene flow are clearly of the same order
of magnitude in the two species. The relatively high per locus selection coefficients
agree with ``major gene'' theories for the evolution of Mullerian mimicry, but
the genetic architecture of the color patterns does not. These results show that
the genetics and evolution of mimicry are still only sketchily understood.
acknowledgement: 'We thank the Natural Environmental Research Council, the Royal Society,
the Nuffield Foundation, CONCYTEC, and Mrs. G. W. BORLASE for financial support,
and the people of San Martin for their generous hospitality. We are very grateful
to S. D. KNAPP, who helped by maintaining our sanity and rearing larvae. We are
also grateful to an anonymous reviewer, A. W. PORTER, J. C. SCHNEIDER, M. TURELLI
and C. E. WATSON for helpful comments on the manuscript. This paper was approved
for publication as journal article no. 5-7255 of the Mississippi Agricultural and
Forestry Experiment Station, Mississippi State University, project no. MIS-2 122. '
article_processing_charge: No
article_type: original
author:
- first_name: James
full_name: Mallet, James
last_name: Mallet
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Gerado
full_name: Lamas, Gerado
last_name: Lamas
- first_name: José
full_name: Santisteban, José
last_name: Santisteban
- first_name: Manuel
full_name: Muedas, Manuel
last_name: Muedas
- first_name: Harriet
full_name: Eeley, Harriet
last_name: Eeley
citation:
ama: Mallet J, Barton NH, Lamas G, Santisteban J, Muedas M, Eeley H. Estimates of
selection and gene flow from measures of cline width and linkage disequilibrium
in Heliconius hybrid zones. Genetics. 1990;124(4):921-936. doi:10.1093/genetics/124.4.921
apa: Mallet, J., Barton, N. H., Lamas, G., Santisteban, J., Muedas, M., & Eeley,
H. (1990). Estimates of selection and gene flow from measures of cline width and
linkage disequilibrium in Heliconius hybrid zones. Genetics. Genetics Society
of America. https://doi.org/10.1093/genetics/124.4.921
chicago: Mallet, James, Nicholas H Barton, Gerado Lamas, José Santisteban, Manuel
Muedas, and Harriet Eeley. “Estimates of Selection and Gene Flow from Measures
of Cline Width and Linkage Disequilibrium in Heliconius Hybrid Zones.” Genetics.
Genetics Society of America, 1990. https://doi.org/10.1093/genetics/124.4.921.
ieee: J. Mallet, N. H. Barton, G. Lamas, J. Santisteban, M. Muedas, and H. Eeley,
“Estimates of selection and gene flow from measures of cline width and linkage
disequilibrium in Heliconius hybrid zones,” Genetics, vol. 124, no. 4.
Genetics Society of America, pp. 921–936, 1990.
ista: Mallet J, Barton NH, Lamas G, Santisteban J, Muedas M, Eeley H. 1990. Estimates
of selection and gene flow from measures of cline width and linkage disequilibrium
in Heliconius hybrid zones. Genetics. 124(4), 921–936.
mla: Mallet, James, et al. “Estimates of Selection and Gene Flow from Measures of
Cline Width and Linkage Disequilibrium in Heliconius Hybrid Zones.” Genetics,
vol. 124, no. 4, Genetics Society of America, 1990, pp. 921–36, doi:10.1093/genetics/124.4.921.
short: J. Mallet, N.H. Barton, G. Lamas, J. Santisteban, M. Muedas, H. Eeley, Genetics
124 (1990) 921–936.
date_created: 2018-12-11T12:04:26Z
date_published: 1990-04-01T00:00:00Z
date_updated: 2022-02-23T11:04:17Z
day: '01'
doi: 10.1093/genetics/124.4.921
extern: '1'
external_id:
pmid:
- '2323556'
intvolume: ' 124'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203983/
month: '04'
oa: 1
oa_version: Published Version
page: 921 - 936
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2733'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Estimates of selection and gene flow from measures of cline width and linkage
disequilibrium in Heliconius hybrid zones
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 124
year: '1990'
...
---
_id: '3651'
abstract:
- lang: eng
text: 'It is widely held that each gene typically affects many characters, and that
each character is affected by many genes. Moreover, strong stabilizing selection
cannot act on an indefinitely large number of independent traits. This makes it
likely that heritable variation in any one trait is maintained as a side effect
of polymorphisms which have nothing to do with selection on that trait. This paper
examines the idea that variation is maintained as the pleiotropic side effect
of either deleterious mutation, or balancing selection. If mutation is responsible,
it must produce alleles which are only mildly deleterious (s & 10(-3)), but
nevertheless have significant effects on the trait. Balancing selection can readily
maintain high heritabilities; however, selection must be spread over many weakly
selected polymorphisms if large responses to artificial selection are to be possible.
In both classes of pleiotropic model, extreme phenotypes are less fit, giving
the appearance of stabilizing selection on the trait. However, it is shown that
this effect is weak (of the same order as the selection on each gene): the strong
stabilizing selection which is often observed is likely to be caused by correlations
with a limited number of directly selected traits. Possible experiments for distinguishing
the alternatives are discussed.'
acknowledgement: Thanks to JERRY COYNE, BILL HILL, LINDA PARTRIDGE, MICHAEL TURELLI,
and two anonymous reviewers for their critical comments. This work was supported
by grants from the National Science Foundation (BSR-8866548) the Science and Engineering
Research Council (GR/E/08507), and by the Institute of Theoretical Dynamics, University
of California, Davis.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Pleiotropic models of quantitative variation. Genetics. 1990;124(3):773-782.
doi:10.1093/genetics/124.3.773
apa: Barton, N. H. (1990). Pleiotropic models of quantitative variation. Genetics.
Genetics Society of America. https://doi.org/10.1093/genetics/124.3.773
chicago: Barton, Nicholas H. “Pleiotropic Models of Quantitative Variation.” Genetics.
Genetics Society of America, 1990. https://doi.org/10.1093/genetics/124.3.773 .
ieee: N. H. Barton, “Pleiotropic models of quantitative variation,” Genetics,
vol. 124, no. 3. Genetics Society of America, pp. 773–782, 1990.
ista: Barton NH. 1990. Pleiotropic models of quantitative variation. Genetics. 124(3),
773–782.
mla: Barton, Nicholas H. “Pleiotropic Models of Quantitative Variation.” Genetics,
vol. 124, no. 3, Genetics Society of America, 1990, pp. 773–82, doi:10.1093/genetics/124.3.773 .
short: N.H. Barton, Genetics 124 (1990) 773–782.
date_created: 2018-12-11T12:04:26Z
date_published: 1990-03-01T00:00:00Z
date_updated: 2022-02-23T10:41:43Z
day: '01'
doi: '10.1093/genetics/124.3.773 '
extern: '1'
external_id:
pmid:
- '2311921'
intvolume: ' 124'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/124/3/773/5999956?login=true
month: '03'
oa: 1
oa_version: Published Version
page: 773 - 782
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2732'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Pleiotropic models of quantitative variation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 124
year: '1990'
...
---
_id: '4060'
abstract:
- lang: eng
text: This paper offers combinatorial results on extremum problems concerning the
number of tetrahedra in a tetrahedrization of n points in general position in
three dimensions, i.e. such that no four points are co-planar, It also presents
an algorithm that in O(n log n) time constructs a tetrahedrization of a set of
n points consisting of at most 3n-11 tetrahedra.
acknowledgement: Research of the first author is supported by Amoco Fnd. Fac. Dec.
Comput. Sci. 1-6-44862, the second author is supported by NSF Grant ECS 84-10902,
and research of the third author is supported in part by ONR Grant N00014-85K0570
and by NSF Grant DMS 8504322.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Franco
full_name: Preparata, Franco
last_name: Preparata
- first_name: Douglas
full_name: West, Douglas
last_name: West
citation:
ama: Edelsbrunner H, Preparata F, West D. Tetrahedrizing point sets in three dimensions.
Journal of Symbolic Computation. 1990;10(3-4):335-347. doi:10.1016/S0747-7171(08)80068-5
apa: Edelsbrunner, H., Preparata, F., & West, D. (1990). Tetrahedrizing point
sets in three dimensions. Journal of Symbolic Computation. Elsevier. https://doi.org/10.1016/S0747-7171(08)80068-5
chicago: Edelsbrunner, Herbert, Franco Preparata, and Douglas West. “Tetrahedrizing
Point Sets in Three Dimensions.” Journal of Symbolic Computation. Elsevier,
1990. https://doi.org/10.1016/S0747-7171(08)80068-5.
ieee: H. Edelsbrunner, F. Preparata, and D. West, “Tetrahedrizing point sets in
three dimensions,” Journal of Symbolic Computation, vol. 10, no. 3–4. Elsevier,
pp. 335–347, 1990.
ista: Edelsbrunner H, Preparata F, West D. 1990. Tetrahedrizing point sets in three
dimensions. Journal of Symbolic Computation. 10(3–4), 335–347.
mla: Edelsbrunner, Herbert, et al. “Tetrahedrizing Point Sets in Three Dimensions.”
Journal of Symbolic Computation, vol. 10, no. 3–4, Elsevier, 1990, pp.
335–47, doi:10.1016/S0747-7171(08)80068-5.
short: H. Edelsbrunner, F. Preparata, D. West, Journal of Symbolic Computation 10
(1990) 335–347.
date_created: 2018-12-11T12:06:42Z
date_published: 1990-01-01T00:00:00Z
date_updated: 2022-02-23T10:10:35Z
day: '01'
doi: 10.1016/S0747-7171(08)80068-5
extern: '1'
intvolume: ' 10'
issue: 3-4
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0747717108800685?via%3Dihub
month: '01'
oa: 1
oa_version: Published Version
page: 335 - 347
publication: Journal of Symbolic Computation
publication_identifier:
eissn:
- 1095-855X
issn:
- 0747-7171
publication_status: published
publisher: Elsevier
publist_id: '2061'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tetrahedrizing point sets in three dimensions
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1990'
...
---
_id: '2480'
abstract:
- lang: eng
text: Functional cDNA clones for rat neuromedin K receptor were isolated from a
rat brain cDNA library by cross-hybridization with the bovine substance K recepor
cDNA. Injection of the mRNA synthesized in vitro from the cloned cDNA into Xenopus
oocytes elicited electrophysiological responses to tachykinins, with the most
potent sensitivity being to neuromedin K. Ligand-binding displacement in membranes
of mammalian COS cells transfected with the cDNA indicated the rank order of affinity
of the receptor to tachykinins; neuromedin K > substance K > substance P.
The hybridization analysis showed that the neuromedin K receptor mRNA is expressed
in both the brain and the peripheral tissues at different levels. The rat neuromedin
K receptor consists of 452 amino acid residues and belongs to the family of G
protein-coupled receptors, which are thought to have seven transmembrane domains.
The sequence comparison of the rat neuromedin K, substance P, and substance K
receptors revealed that these receptors are highly conserved in the seven transmembrane
domains and the cytoplasmic sides of the receptors. They also show some structural
characteristics, including the common presence of histidine residues in transmembrane
segments V and VI and the difference in the numbers and distributions of serine
and threonine residues as possible phosphorylation sites in the cytoplasmic regions.
This paper thus presents the first comprehensive analysis of the molecular nature
of the multiple peptide receptors that exhibit similar but pharmacologically distinguishable
activities.
acknowledgement: This work was supported in part by research grants from the Ministry
Education, Science and Culture of Japan; the Institute of Physical and Chemical
Research; and the Science and Technology Agency of Japan. The costs of publication
of this article were defrayed in part by the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 USC. Section
1734 solely to indicate this fact.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yoshifumi
full_name: Yokota, Yoshifumi
last_name: Yokota
- first_name: Kunihiro
full_name: Tsuchida, Kunihiro
last_name: Tsuchida
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Shigemoto R, Yokota Y, Tsuchida K, Nakanishi S. Cloning and expression of a
rat neuromedin K receptor cDNA. Journal of Biological Chemistry. 1990;265(2):623-628.
doi:10.1016/s0021-9258(19)40095-1
apa: Shigemoto, R., Yokota, Y., Tsuchida, K., & Nakanishi, S. (1990). Cloning
and expression of a rat neuromedin K receptor cDNA. Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/s0021-9258(19)40095-1
chicago: Shigemoto, Ryuichi, Yoshifumi Yokota, Kunihiro Tsuchida, and Shigetada
Nakanishi. “Cloning and Expression of a Rat Neuromedin K Receptor CDNA.” Journal
of Biological Chemistry. American Society for Biochemistry and Molecular Biology,
1990. https://doi.org/10.1016/s0021-9258(19)40095-1
.
ieee: R. Shigemoto, Y. Yokota, K. Tsuchida, and S. Nakanishi, “Cloning and expression
of a rat neuromedin K receptor cDNA,” Journal of Biological Chemistry,
vol. 265, no. 2. American Society for Biochemistry and Molecular Biology, pp.
623–628, 1990.
ista: Shigemoto R, Yokota Y, Tsuchida K, Nakanishi S. 1990. Cloning and expression
of a rat neuromedin K receptor cDNA. Journal of Biological Chemistry. 265(2),
623–628.
mla: Shigemoto, Ryuichi, et al. “Cloning and Expression of a Rat Neuromedin K Receptor
CDNA.” Journal of Biological Chemistry, vol. 265, no. 2, American Society
for Biochemistry and Molecular Biology, 1990, pp. 623–28, doi:10.1016/s0021-9258(19)40095-1 .
short: R. Shigemoto, Y. Yokota, K. Tsuchida, S. Nakanishi, Journal of Biological
Chemistry 265 (1990) 623–628.
date_created: 2018-12-11T11:57:55Z
date_published: 1990-01-15T00:00:00Z
date_updated: 2022-02-24T11:07:05Z
day: '15'
doi: '10.1016/s0021-9258(19)40095-1 '
extern: '1'
external_id:
pmid:
- '2153106 '
intvolume: ' 265'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925819400951
month: '01'
oa: 1
oa_version: Published Version
page: 623 - 628
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
eissn:
- 1083-351X
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4421'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cloning and expression of a rat neuromedin K receptor cDNA
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 265
year: '1990'
...
---
_id: '2481'
abstract:
- lang: eng
text: The family of mammalian tachykinin receptors consists of substance P receptor
(SPR), neuromedin K receptor (NKR) and substance K receptor (SKR). In this investigation,
tissue and regional distributions of the mRNAs for the three rat tachykinin receptors
were investigated by blot-hybridization and RNase-protection analyses using the
previously cloned receptor cDNAs. SPR mRNA is widely distributed in both the nervous
system and peripheral tissues and is expressed abundantly in the hypothalamus
and olfactory buld, as well as in the urinary bladder, salivary glands and small
and large intestines. In contrast, NKR mRNA is predominantly expressed in the
nervous system, particularly in the cortex, hypothalamus and cerebellum, whereas
SKR mRNA expression is restricted to the peripheral tissues, being abundant in
the urinary bladder, large intestine, stomach and adenal glands. Thus, the mRNAs
for the three tachykinin receptors show distinct patterns of expression between
the nervous system and peripheral tissues. Blot-hybridization analysis in combination
with S1 nuclease protection and primer-extension analyses revealed that there
are two large forms of SKR mRNA expressed commonly in the peripheral tissues,
and two additional small forms of the mRNA expressed specifically in the adrenal
gland and eye. These analyses also showed that the multiple forms of SKR mRNA
differ in the lengths of the 5' mRNA portions, and that the two small forms of
the mRNA, if translated, encode a truncated SKR polypeptide lacking the first
two transmembrane domains. This investigation thus provides the comprehensive
analysis of the distribution and mode of expression of the mRNAs for the multiple
peptide receptors and offers a new basis on which to interpret the diverse functions
of multiple tachykinin peptides in the CNS and peripheral tissues.
acknowledgement: This work was supported in part by research grants from the Ministry
of Education, Science and Culture of Japan, the Ministry of Health and Welfare
of Japan, and the Yamanouchi Foundation for Research on Metabolic Disorders
article_processing_charge: No
article_type: original
author:
- first_name: Kunihiro
full_name: Tsuchida, Kunihiro
last_name: Tsuchida
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yoshifumi
full_name: Yokota, Yoshifumi
last_name: Yokota
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Tsuchida K, Shigemoto R, Yokota Y, Nakanishi S. Tissue distribution and quantitation
of the mRNAs for three rat tachykinin receptors. European Journal of Biochemistry.
1990;193(3):751-757. doi:10.1111/j.1432-1033.1990.tb19396.x
apa: Tsuchida, K., Shigemoto, R., Yokota, Y., & Nakanishi, S. (1990). Tissue
distribution and quantitation of the mRNAs for three rat tachykinin receptors.
European Journal of Biochemistry. Wiley-Blackwell. https://doi.org/10.1111/j.1432-1033.1990.tb19396.x
chicago: Tsuchida, Kunihiro, Ryuichi Shigemoto, Yoshifumi Yokota, and Shigetada
Nakanishi. “Tissue Distribution and Quantitation of the MRNAs for Three Rat Tachykinin
Receptors.” European Journal of Biochemistry. Wiley-Blackwell, 1990. https://doi.org/10.1111/j.1432-1033.1990.tb19396.x.
ieee: K. Tsuchida, R. Shigemoto, Y. Yokota, and S. Nakanishi, “Tissue distribution
and quantitation of the mRNAs for three rat tachykinin receptors,” European
Journal of Biochemistry, vol. 193, no. 3. Wiley-Blackwell, pp. 751–757, 1990.
ista: Tsuchida K, Shigemoto R, Yokota Y, Nakanishi S. 1990. Tissue distribution
and quantitation of the mRNAs for three rat tachykinin receptors. European Journal
of Biochemistry. 193(3), 751–757.
mla: Tsuchida, Kunihiro, et al. “Tissue Distribution and Quantitation of the MRNAs
for Three Rat Tachykinin Receptors.” European Journal of Biochemistry,
vol. 193, no. 3, Wiley-Blackwell, 1990, pp. 751–57, doi:10.1111/j.1432-1033.1990.tb19396.x.
short: K. Tsuchida, R. Shigemoto, Y. Yokota, S. Nakanishi, European Journal of Biochemistry
193 (1990) 751–757.
date_created: 2018-12-11T11:57:55Z
date_published: 1990-03-03T00:00:00Z
date_updated: 2022-02-24T10:20:14Z
day: '03'
doi: 10.1111/j.1432-1033.1990.tb19396.x
extern: '1'
external_id:
pmid:
- '1701145'
intvolume: ' 193'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://febs.onlinelibrary.wiley.com/doi/10.1111/j.1432-1033.1990.tb19396.x
month: '03'
oa: 1
oa_version: Published Version
page: 751 - 757
pmid: 1
publication: European Journal of Biochemistry
publication_identifier:
eissn:
- 1432-1033
issn:
- 0014-2956
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4420'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tissue distribution and quantitation of the mRNAs for three rat tachykinin
receptors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 193
year: '1990'
...