---
_id: '3486'
abstract:
- lang: eng
text: 1. Dendritic patch-clamp recordings were obtained from mitral cells in rat
olfactory bulb slices, up to 350 μm from the soma. Simultaneous dendritic and
somatic whole-cell recordings indicated that action potentials (APs) evoked by
somatic or dendritic current injection were initiated near the soma. Both the
large amplitude (100.7 ± 1.1 mV) and the short duration (1.38 ± 0.07 ms) of the
AP were maintained as the AP propagated back into the primary mitral cell dendrites.
2. Outside-out patches isolated from mitral cell dendrites contained voltage-gated
Na+ channels (peak conductance density, 90 pS μm-2 at -10 mV). When an AP was
used as a somatic voltage-clamp command in the presence of 1 μM tetrodotoxin (TTX),
the amplitude of the dendritic potential was attenuated to 48 ± 14 mV. This shows
that dendritic Na+ channels support the active back-propagation of APs. 3. Dendritic
patches contained voltage-gated K+ channels with high density (conductance density,
513 pS μm-2 at 30 mV. Dendritic K+ currents were reduced to 35% by 1 mM external
tetraethylammonium chloride (TEACl). When an AP was used as a somatic voltage
clamp command in the presence of TEACl, the dendritic potential was markedly prolonged.
This indicates that dendritic K+ channels mediate the fast repolarization of dendritic
APs. 4. We conclude that voltage gated Na+ and K+ channels support dendritic APs
with large amplitudes and short durations that may trigger fast transmitter release
at dendrodendritic synapses in the olfactory bulb.
acknowledgement: We thank Drs J. R. P. Geiger, M. Martina, and D. Schild for critically
reading the manuscript, and Mrs B. Plessow-Freudenberg for technical assistance.
This work was supported by DFG grant BI 642/1-1 and German Israeli Foundation grant
I 0352-073.01/94.
article_processing_charge: No
article_type: original
author:
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bischofberger J, Jonas PM. Action potential propagation into the presynaptic
dendrites of rat mitral cells. Journal of Physiology. 1997;504(Pt 2):359-365.
doi:10.1111/j.1469-7793.1997.359be.x
apa: Bischofberger, J., & Jonas, P. M. (1997). Action potential propagation
into the presynaptic dendrites of rat mitral cells. Journal of Physiology.
Wiley-Blackwell. https://doi.org/10.1111/j.1469-7793.1997.359be.x
chicago: Bischofberger, Joseph, and Peter M Jonas. “Action Potential Propagation
into the Presynaptic Dendrites of Rat Mitral Cells.” Journal of Physiology.
Wiley-Blackwell, 1997. https://doi.org/10.1111/j.1469-7793.1997.359be.x.
ieee: J. Bischofberger and P. M. Jonas, “Action potential propagation into the presynaptic
dendrites of rat mitral cells,” Journal of Physiology, vol. 504, no. Pt
2. Wiley-Blackwell, pp. 359–365, 1997.
ista: Bischofberger J, Jonas PM. 1997. Action potential propagation into the presynaptic
dendrites of rat mitral cells. Journal of Physiology. 504(Pt 2), 359–365.
mla: Bischofberger, Joseph, and Peter M. Jonas. “Action Potential Propagation into
the Presynaptic Dendrites of Rat Mitral Cells.” Journal of Physiology,
vol. 504, no. Pt 2, Wiley-Blackwell, 1997, pp. 359–65, doi:10.1111/j.1469-7793.1997.359be.x.
short: J. Bischofberger, P.M. Jonas, Journal of Physiology 504 (1997) 359–365.
date_created: 2018-12-11T12:03:35Z
date_published: 1997-10-15T00:00:00Z
date_updated: 2022-08-19T12:02:21Z
day: '15'
doi: 10.1111/j.1469-7793.1997.359be.x
extern: '1'
external_id:
pmid:
- '9365910'
intvolume: ' 504'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1159916/
month: '10'
oa: 1
oa_version: Published Version
page: 359 - 365
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2901'
quality_controlled: '1'
status: public
title: Action potential propagation into the presynaptic dendrites of rat mitral cells
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 504
year: '1997'
...
---
_id: '3630'
abstract:
- lang: eng
text: This paper derives the long-term effective size, Ne, for a general model of
population subdivision, allowing for differential deme fitness, variable emigration
and immigration rates, extinction, colonization, and correlations across generations
in these processes. We show that various long-term measures of Ne are equivalent.
The effective size of a metapopulation can be expressed in a variety of ways.
At a demographic equilibrium, Ne can be derived from the demography by combining
information about the ultimate contribution of each deme to the future genetic
make-up of the population and Wright's FST's. The effective size is given by Ne
= 1/(1 + var (upsilon) ((1 - FST)/Nin), where n is the number of demes, theta
i is the eventual contribution of individuals in deme i to the whole population
(scaled such that sigma theta i = n), and < > denotes an average weighted
by theta i. This formula is applied to a catastrophic extinction model (where
sites are either empty or at carrying capacity) and to a metapopulation model
with explicit dynamics, where extinction is caused by demographic stochasticity
and by chaos. Contrary to the expectation from the standard island model, the
usual effect of population subdivision is to decrease the effective size relative
to a panmictic population living on the same resource.
acknowledgement: This paper has benefited greatly from the kind efforts oF ARMANDO
CABALLERO, PETER KEIGHTLEY, BEATE NÜRNBERCER and SALLY OTTO in reading and discussing
the manuscript. We also thank MONTY SLATKIN and three anonymous reviewers for their
helpful comments. One of these reviewers in particular greatly improved this paper.
The work reported here was supported by a grant from the Science and Engineering
Research Council (U.R) and the Darwin Trust of Edinburgh, as well as by the Natural
Sciences and Engineering Research Council (Canada).
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Whitlock, Michael
last_name: Whitlock
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Whitlock M, Barton NH. The effective size of a subdivided population. Genetics.
1997;146(1):427-441. doi:10.1093/genetics/146.1.427
apa: Whitlock, M., & Barton, N. H. (1997). The effective size of a subdivided
population. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/146.1.427
chicago: Whitlock, Michael, and Nicholas H Barton. “The Effective Size of a Subdivided
Population.” Genetics. Genetics Society of America, 1997. https://doi.org/10.1093/genetics/146.1.427.
ieee: M. Whitlock and N. H. Barton, “The effective size of a subdivided population,”
Genetics, vol. 146, no. 1. Genetics Society of America, pp. 427–441, 1997.
ista: Whitlock M, Barton NH. 1997. The effective size of a subdivided population.
Genetics. 146(1), 427–441.
mla: Whitlock, Michael, and Nicholas H. Barton. “The Effective Size of a Subdivided
Population.” Genetics, vol. 146, no. 1, Genetics Society of America, 1997,
pp. 427–41, doi:10.1093/genetics/146.1.427.
short: M. Whitlock, N.H. Barton, Genetics 146 (1997) 427–441.
date_created: 2018-12-11T12:04:20Z
date_published: 1997-05-01T00:00:00Z
date_updated: 2022-08-19T10:01:10Z
day: '01'
doi: 10.1093/genetics/146.1.427
extern: '1'
external_id:
pmid:
- '9136031 '
intvolume: ' 146'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/146/1/427/6053913
month: '05'
oa: 1
oa_version: Published Version
page: 427 - 441
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2753'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effective size of a subdivided population
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 146
year: '1997'
...
---
_id: '3631'
abstract:
- lang: eng
text: In spatially heterogeneous environments, natural selection for maintenance
of adaptation to habitats that contribute little to the population's reproduction
is weak. In this paper we model a mechanism that can result in loss of fitness
in such marginal habitats, and thus lead to specialisation on the main habitat.
It involves accumulation of mutations that are deleterious in the marginal habitat
but neutral or nearly so in the main habitat (mutations deleterious in the main
habitat and neutral in the marginal habitat have a negligible influence). If the
contribution of the marginal habitat to total reproduction in the absence of the
mutations is less than a threshold value, selection is too weak to counter accumulation
of such mutations. A positive feedback then results in loss of fitness in the
marginal habitat. This mechanism does not require antagonistic pleiotropy in adaptation
to different habitats, although antagonistic pleiotropy facilitates the mutational
collapse of fitness in the marginal habitat. We suggest that deleterious mutations
with habitat-specific expression may play a role in the evolution of ecological
specialisation and promote evolutionary conservatism of ecological niches.
article_processing_charge: No
article_type: original
author:
- first_name: Tadeusz
full_name: Kawecki, Tadeusz
last_name: Kawecki
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: James
full_name: Fry, James
last_name: Fry
citation:
ama: Kawecki T, Barton NH, Fry J. Mutational collapse of fitness in marginal habitats
and the evolution of ecological specialisation. Journal of Evolutionary Biology.
1997;10(3):407-430. doi:10.1046/j.1420-9101.1997.10030407.x
apa: Kawecki, T., Barton, N. H., & Fry, J. (1997). Mutational collapse of fitness
in marginal habitats and the evolution of ecological specialisation. Journal
of Evolutionary Biology. Wiley-Blackwell. https://doi.org/10.1046/j.1420-9101.1997.10030407.x
chicago: Kawecki, Tadeusz, Nicholas H Barton, and James Fry. “Mutational Collapse
of Fitness in Marginal Habitats and the Evolution of Ecological Specialisation.”
Journal of Evolutionary Biology. Wiley-Blackwell, 1997. https://doi.org/10.1046/j.1420-9101.1997.10030407.x.
ieee: T. Kawecki, N. H. Barton, and J. Fry, “Mutational collapse of fitness in marginal
habitats and the evolution of ecological specialisation,” Journal of Evolutionary
Biology, vol. 10, no. 3. Wiley-Blackwell, pp. 407–430, 1997.
ista: Kawecki T, Barton NH, Fry J. 1997. Mutational collapse of fitness in marginal
habitats and the evolution of ecological specialisation. Journal of Evolutionary
Biology. 10(3), 407–430.
mla: Kawecki, Tadeusz, et al. “Mutational Collapse of Fitness in Marginal Habitats
and the Evolution of Ecological Specialisation.” Journal of Evolutionary Biology,
vol. 10, no. 3, Wiley-Blackwell, 1997, pp. 407–30, doi:10.1046/j.1420-9101.1997.10030407.x.
short: T. Kawecki, N.H. Barton, J. Fry, Journal of Evolutionary Biology 10 (1997)
407–430.
date_created: 2018-12-11T12:04:20Z
date_published: 1997-05-01T00:00:00Z
date_updated: 2022-08-19T09:46:51Z
day: '01'
doi: 10.1046/j.1420-9101.1997.10030407.x
extern: '1'
intvolume: ' 10'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1420-9101.1997.10030407.x
month: '05'
oa: 1
oa_version: Published Version
page: 407 - 430
publication: Journal of Evolutionary Biology
publication_identifier:
issn:
- 1010-061X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2752'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mutational collapse of fitness in marginal habitats and the evolution of ecological
specialisation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1997'
...
---
_id: '3632'
abstract:
- lang: eng
text: An important but controversial class of hypotheses concerning the evolution
of female preferences for extreme male mating displays involves 'indirect selection.'
Even in the absence of direct fitness effects, preference for males with high
overall fitness can spread via a genetic correlation that develops between preference
alleles and high fitness genotypes. Here we develop a quantitative expression
for the force of indirect selection that (i) applies to any female mating behavior,
(ii) is relatively insensitive to the underlying genetics, and (iii) is based
on measurable quantities. In conjunction with the limited data now available,
it suggests that the evolutionary force generated by indirect selection on preferences
is weak in absolute terms. This finding raises the possibility that direct selection
on preference genes may often be more important than indirect selection, but more
data on the quantities identified by our model and on direct selection are needed
to decide the question.
acknowledgement: We thank J. J. Bull, M. J. Ryan, M. Wade, B. Walsh, G. C. Williams,
and an anonymous reviewer for discussions and suggestions. This research was supported
by National Science Foundation Grant DEB94 – 07969, Biotechnology and Biological
Sciences Research Council Grants GRyHy09928 and GRyJy76057, and a travel grant from
the Burroughs-Wellcome Fund.
article_processing_charge: No
article_type: original
author:
- first_name: Mark
full_name: Kirkpatrick, Mark
last_name: Kirkpatrick
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kirkpatrick M, Barton NH. The strength of indirect selection on female mating
preferences. PNAS. 1997;94(4):1282-1286. doi:10.1073/pnas.94.4.1282
apa: Kirkpatrick, M., & Barton, N. H. (1997). The strength of indirect selection
on female mating preferences. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.94.4.1282
chicago: Kirkpatrick, Mark, and Nicholas H Barton. “The Strength of Indirect Selection
on Female Mating Preferences.” PNAS. National Academy of Sciences, 1997.
https://doi.org/10.1073/pnas.94.4.1282.
ieee: M. Kirkpatrick and N. H. Barton, “The strength of indirect selection on female
mating preferences,” PNAS, vol. 94, no. 4. National Academy of Sciences,
pp. 1282–1286, 1997.
ista: Kirkpatrick M, Barton NH. 1997. The strength of indirect selection on female
mating preferences. PNAS. 94(4), 1282–1286.
mla: Kirkpatrick, Mark, and Nicholas H. Barton. “The Strength of Indirect Selection
on Female Mating Preferences.” PNAS, vol. 94, no. 4, National Academy of
Sciences, 1997, pp. 1282–86, doi:10.1073/pnas.94.4.1282.
short: M. Kirkpatrick, N.H. Barton, PNAS 94 (1997) 1282–1286.
date_created: 2018-12-11T12:04:21Z
date_published: 1997-02-18T00:00:00Z
date_updated: 2022-08-19T09:25:21Z
day: '18'
doi: 10.1073/pnas.94.4.1282
extern: '1'
external_id:
pmid:
- '9037044 '
intvolume: ' 94'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://europepmc.org/article/med/9037044
month: '02'
oa: 1
oa_version: Published Version
page: 1282 - 1286
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2751'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The strength of indirect selection on female mating preferences
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 94
year: '1997'
...
---
_id: '4021'
abstract:
- lang: eng
text: A homeomorphism from R-2 to itself distorts metric quantities, such as distance
and area. We describe an algorithm that constructs homeomorphisms with prescribed
area distortion. Such homeomorphisms can be used to generate cartograms, which
are geographic maps purposely distorted so their area distributions reflects a
variable different from area, as for example population density. The algorithm
generates the homeomorphism through a sequence of local piecewise linear homeomorphic
changes. Sample results produced by the preliminary implementation of the method
are included.
acknowledgement: 'The authors thank Jack Snoeyink for bringing the cartogram problem
to their attention, and Michael McAllister for providing pointers to the literature
on cartograms. '
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Roman
full_name: Waupotitsch, Roman
last_name: Waupotitsch
citation:
ama: 'Edelsbrunner H, Waupotitsch R. A combinatorial approach to cartograms. Computational
Geometry: Theory and Applications. 1997;7(5-6):343-360. doi:10.1016/S0925-7721(96)00006-5'
apa: 'Edelsbrunner, H., & Waupotitsch, R. (1997). A combinatorial approach to
cartograms. Computational Geometry: Theory and Applications. Elsevier.
https://doi.org/10.1016/S0925-7721(96)00006-5'
chicago: 'Edelsbrunner, Herbert, and Roman Waupotitsch. “A Combinatorial Approach
to Cartograms.” Computational Geometry: Theory and Applications. Elsevier,
1997. https://doi.org/10.1016/S0925-7721(96)00006-5.'
ieee: 'H. Edelsbrunner and R. Waupotitsch, “A combinatorial approach to cartograms,”
Computational Geometry: Theory and Applications, vol. 7, no. 5–6. Elsevier,
pp. 343–360, 1997.'
ista: 'Edelsbrunner H, Waupotitsch R. 1997. A combinatorial approach to cartograms.
Computational Geometry: Theory and Applications. 7(5–6), 343–360.'
mla: 'Edelsbrunner, Herbert, and Roman Waupotitsch. “A Combinatorial Approach to
Cartograms.” Computational Geometry: Theory and Applications, vol. 7, no.
5–6, Elsevier, 1997, pp. 343–60, doi:10.1016/S0925-7721(96)00006-5.'
short: 'H. Edelsbrunner, R. Waupotitsch, Computational Geometry: Theory and Applications
7 (1997) 343–360.'
date_created: 2018-12-11T12:06:29Z
date_published: 1997-04-01T00:00:00Z
date_updated: 2022-08-19T08:12:03Z
day: '01'
doi: 10.1016/S0925-7721(96)00006-5
extern: '1'
intvolume: ' 7'
issue: 5-6
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0925772196000065
month: '04'
oa: 1
oa_version: Published Version
page: 343 - 360
popular_science: '1'
publication: 'Computational Geometry: Theory and Applications'
publication_identifier:
issn:
- 0925-7721
publication_status: published
publisher: Elsevier
publist_id: '2105'
status: public
title: A combinatorial approach to cartograms
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '1997'
...
---
_id: '4174'
abstract:
- lang: eng
text: The epiphysial region of the dorsal diencephalon is the first site at which
neurogenesis occurs in the roof of the zebrafish forebrain. We show that the homeobox
containing gene floating head (flh) is required for neurogenesis to proceed in
the epiphysis. In flh(-) embryos, the first few epiphysial neurons are generated,
but beyond the 18 somite stage, neuronal production ceases. In contrast, in masterblind(-)
(mbl(-)) embryos, epiphysial neurons are generated throughout the dorsal forebrain.
We show that mbl is required to prevent the expression of flh in dorsal forebrain
cells rostral to the epiphysis. Furthermore, epiphysial neurons are not ectopically
induced in mbl(-)/flh(-) embryos, demonstrating that the epiphysial phenotype
of mbl(-) embryos is mediated by ectopic Flh activity. We propose a role for Flh
in linking the signaling pathways that regulate regional patterning to the signaling
pathways that regulate neurogenesis.
acknowledgement: 'We thank Igor DaMd. Tom Jessell, David Kimelman. Vladimir Koah,
Karen Larison. Ingvild Mikkola, Laurie Molday. and Eric Weinberg for probes and
antibod-ies: Alex Schist and Juliet Williams for help with the TUNEL tech-nique;
Dominic Delaney for analysis of the fih neural plate: Brian Gashing and Geraldine
Millard for fish care; Christian Nusslein Volhard for her support: and Corinne Houart.
Nigel Holder, and other members of the DBRC for comments on the manuscript. Electron
microscopy of the developing epiphysis cited in this study was carried out with
the help of Celeste Malinoski. funded by a grant (EY-00168)awarded to Stephen S.
Easter. This study was supported by grants from Welcome Trust to S. W. and Human
Frontier Science Program to I. M. S.W. is a Wellcome Trust Senior Research Fellow. '
article_processing_charge: No
article_type: original
author:
- first_name: Ichiro
full_name: Masai, Ichiro
last_name: Masai
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: K Anukampa
full_name: Barth, K Anukampa
last_name: Barth
- first_name: Rachel
full_name: Macdonald, Rachel
last_name: Macdonald
- first_name: Sylwia
full_name: Adamek, Sylwia
last_name: Adamek
- first_name: Stephen
full_name: Wilson, Stephen
last_name: Wilson
citation:
ama: Masai I, Heisenberg C-PJ, Barth KA, Macdonald R, Adamek S, Wilson S. Floating
head and masterblind regulate neuronal patterning in the roof of the forebrain.
Neuron. 1997;18(1):43-57. doi:10.1016/S0896-6273(01)80045-3
apa: Masai, I., Heisenberg, C.-P. J., Barth, K. A., Macdonald, R., Adamek, S., &
Wilson, S. (1997). Floating head and masterblind regulate neuronal patterning
in the roof of the forebrain. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(01)80045-3
chicago: Masai, Ichiro, Carl-Philipp J Heisenberg, K Anukampa Barth, Rachel Macdonald,
Sylwia Adamek, and Stephen Wilson. “Floating Head and Masterblind Regulate Neuronal
Patterning in the Roof of the Forebrain.” Neuron. Elsevier, 1997. https://doi.org/10.1016/S0896-6273(01)80045-3.
ieee: I. Masai, C.-P. J. Heisenberg, K. A. Barth, R. Macdonald, S. Adamek, and S.
Wilson, “Floating head and masterblind regulate neuronal patterning in the roof
of the forebrain,” Neuron, vol. 18, no. 1. Elsevier, pp. 43–57, 1997.
ista: Masai I, Heisenberg C-PJ, Barth KA, Macdonald R, Adamek S, Wilson S. 1997.
Floating head and masterblind regulate neuronal patterning in the roof of the
forebrain. Neuron. 18(1), 43–57.
mla: Masai, Ichiro, et al. “Floating Head and Masterblind Regulate Neuronal Patterning
in the Roof of the Forebrain.” Neuron, vol. 18, no. 1, Elsevier, 1997,
pp. 43–57, doi:10.1016/S0896-6273(01)80045-3.
short: I. Masai, C.-P.J. Heisenberg, K.A. Barth, R. Macdonald, S. Adamek, S. Wilson,
Neuron 18 (1997) 43–57.
date_created: 2018-12-11T12:07:24Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-18T14:02:49Z
day: '01'
doi: 10.1016/S0896-6273(01)80045-3
extern: '1'
external_id:
pmid:
- '9010204'
intvolume: ' 18'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0896627301800453?via%3Dihub
month: '01'
oa: 1
oa_version: Published Version
page: 43 - 57
pmid: 1
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
publist_id: '1946'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Floating head and masterblind regulate neuronal patterning in the roof of the
forebrain
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '1997'
...
---
_id: '4201'
abstract:
- lang: eng
text: In zebrafish, as in other vertebrates, an initially singular eye held within
the neural plate has to split during morphogenesis to allow the development of
two separated eyes. It has been suggested that anterior progression of midline
tissue within the neural plate is involved in the bilateralization of the eye
held. Mutations in the recently identified silberblick (slb) gene cause an incomplete
separation of the eyes. During gastrulation and early somitogenesis, the ventral
midline of the central nervous system (CNS) together with the underlying axial
mesendoderm is shortened and broadened in slb embryos. While in wild-type embryos
the ventral CNS midline extends to the anterior limit of the neural plate at the
end of gastrulation, there is a gap between the anterior tip of the ventral CNS
midline and the anterior edge of the neural plate in slb. To investigate the cause
for the shortening of the ventral CNS midline in slb we determined the fate of
labeled ventral CNS midline cells in wild-type and slb embryos at different stages
of development. In slb, anterior migration of ventral CNS midline cells is impaired,
which indicates that migration of these cells is needed for elongation of the
ventral CNS midline. The anterior shortening of the ventral CNS midline in slb
leads to medial instead of bilateral induction of optic stalks followed by a partial
fusion of the eyes at later developmental stages. The analysis of the sIb phenotype
indicates that anterior migration of midline cells within the neural plate is
required for proper induction and subsequent bilateralization of an initially
singular eye field. These findings may therefore provide a starting point in elucidating
the role of neural plate morphogenesis in positioning of the eyes. (C) 1997 Academic
Press.
acknowledgement: 'We thank C. Thisse and Q. Xu for the kind gift of hggl and rtk2
cDNA, respectively. We are grateful to S. Wilson and R. Warga for many valuable
comments on earlier versions of this manuscript. We also thank R. Geisler, D. Gilmour,
M. Granato, I Odenthal, F. Pellegri, S. Schulte-Merker, and F. v. Eeden for critical
reading of the manuscript. '
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Christiane
full_name: Nüsslein Volhard, Christiane
last_name: Nüsslein Volhard
citation:
ama: Heisenberg C-PJ, Nüsslein Volhard C. The function of silberblick in the positioning
of the eye anlage in the zebrafish embryo. Developmental Biology. 1997;184(1):85-94.
doi:10.1006/dbio.1997.8511
apa: Heisenberg, C.-P. J., & Nüsslein Volhard, C. (1997). The function of silberblick
in the positioning of the eye anlage in the zebrafish embryo. Developmental
Biology. Elsevier. https://doi.org/10.1006/dbio.1997.8511
chicago: Heisenberg, Carl-Philipp J, and Christiane Nüsslein Volhard. “The Function
of Silberblick in the Positioning of the Eye Anlage in the Zebrafish Embryo.”
Developmental Biology. Elsevier, 1997. https://doi.org/10.1006/dbio.1997.8511.
ieee: C.-P. J. Heisenberg and C. Nüsslein Volhard, “The function of silberblick
in the positioning of the eye anlage in the zebrafish embryo,” Developmental
Biology, vol. 184, no. 1. Elsevier, pp. 85–94, 1997.
ista: Heisenberg C-PJ, Nüsslein Volhard C. 1997. The function of silberblick in
the positioning of the eye anlage in the zebrafish embryo. Developmental Biology.
184(1), 85–94.
mla: Heisenberg, Carl-Philipp J., and Christiane Nüsslein Volhard. “The Function
of Silberblick in the Positioning of the Eye Anlage in the Zebrafish Embryo.”
Developmental Biology, vol. 184, no. 1, Elsevier, 1997, pp. 85–94, doi:10.1006/dbio.1997.8511.
short: C.-P.J. Heisenberg, C. Nüsslein Volhard, Developmental Biology 184 (1997)
85–94.
date_created: 2018-12-11T12:07:33Z
date_published: 1997-04-01T00:00:00Z
date_updated: 2022-08-18T13:54:19Z
day: '01'
doi: 10.1006/dbio.1997.8511
extern: '1'
external_id:
pmid:
- '9142986 '
intvolume: ' 184'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0012160697985110?via%3Dihub
month: '04'
oa: 1
oa_version: Published Version
page: 85 - 94
pmid: 1
publication: Developmental Biology
publication_identifier:
eissn:
- 0012-1606
publication_status: published
publisher: Elsevier
publist_id: '1917'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The function of silberblick in the positioning of the eye anlage in the zebrafish
embryo
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 184
year: '1997'
...
---
_id: '4285'
abstract:
- lang: eng
text: One of the oldest hypotheses for the advantage of recombination is that recombination
allo rvs beneficial mutations that arise in different individuals to be placed
together on the same chromosome. Unless recombination occurs, one of the beneficial
alleles is doomed to extinction, slowing the rate at which adaptive mutations
are incorporated within a population. We model the effects of a modifier of recombination
on the fixation probability of beneficial mutations when beneficial alleles are
segregating at other loci. We find that modifier alleles that increase recombination
do increase the fixation probability of beneficial mutants and subsequently hitchhike
along as the mutants rise in frequency. The strength of selection favoring a modifier
that increases recombination is proportional to lambda(2)S delta r/r when linkage
is tight and lambda(2)S(3) delta r/N when linkage is loose, where lambda is the
beneficial mutation rate per genome per generation throughout a population of
size N, S is the average mutant effect, r is the average recombination rate, and
delta ris the amount that recombination is modified. We conclude that selection
for recombination will be substantial only if there is tight linkage within the
genome or if many loci are subject to directional selection as during periods
of rapid evolutionary change.
article_processing_charge: No
article_type: original
author:
- first_name: Sarah
full_name: Otto, Sarah
last_name: Otto
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Otto S, Barton NH. The evolution of recombination: Removing the limits to
natural selection. Genetics. 1997;147(2):879-906. doi:10.1093/genetics/147.2.879'
apa: 'Otto, S., & Barton, N. H. (1997). The evolution of recombination: Removing
the limits to natural selection. Genetics. Genetics Society of America.
https://doi.org/10.1093/genetics/147.2.879'
chicago: 'Otto, Sarah, and Nicholas H Barton. “The Evolution of Recombination: Removing
the Limits to Natural Selection.” Genetics. Genetics Society of America,
1997. https://doi.org/10.1093/genetics/147.2.879.'
ieee: 'S. Otto and N. H. Barton, “The evolution of recombination: Removing the limits
to natural selection,” Genetics, vol. 147, no. 2. Genetics Society of America,
pp. 879–906, 1997.'
ista: 'Otto S, Barton NH. 1997. The evolution of recombination: Removing the limits
to natural selection. Genetics. 147(2), 879–906.'
mla: 'Otto, Sarah, and Nicholas H. Barton. “The Evolution of Recombination: Removing
the Limits to Natural Selection.” Genetics, vol. 147, no. 2, Genetics Society
of America, 1997, pp. 879–906, doi:10.1093/genetics/147.2.879.'
short: S. Otto, N.H. Barton, Genetics 147 (1997) 879–906.
date_created: 2018-12-11T12:08:02Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-18T11:36:10Z
day: '01'
doi: 10.1093/genetics/147.2.879
extern: '1'
external_id:
pmid:
- '9335621'
intvolume: ' 147'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/147/2/879/6054161
month: '10'
oa: 1
oa_version: Published Version
page: 879 - 906
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1796'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The evolution of recombination: Removing the limits to natural selection'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 147
year: '1997'
...
---
_id: '4286'
abstract:
- lang: eng
text: A local barrier to gene flow will delay the spread of an advantageous allele.
Exact calculations for the deterministic case show that an allele that is favorable
when rare is delayed very little even by a strong barrier; its spread is allowed
by a time proportional to log((B/σ)√2S)/S, where B is the barrier strength, σ
the dispersal range, and fitnesses are 1:1 + S:1 + 2S. However, when there is
selection against heterozytes, such that the allele cannot increase from low frequency,
a barrier can cause a much greater delay. If gene flow is reduced below a critical
value, spread is entirely prevented. Stochastic simulations show that with additive
selection, random drift slows down the spread of the allele, below the deterministic
speed of σ√2S. The delay to the advance of an advantageous allele caused by a
strong barrier can be substantially increased by random drift and increases with
B/(2Sρσ2) in a one-dimensional habitat of density ρ. However, with selection against
heterozygotes, drift can facilitate the spread and can free an allele that would
otherwise be trapped indefinitely by a strong barrier. We discuss the implications
of these results for the evolution of chromosome rearrangements.
acknowledgement: We are specially grateful to H. C. HAUFFE for allowing us to present
her unpublished data. B. NURNBERGER, J. B. SEARLE, H. C. HAUFFE, S. BAIRD, L. KRUUK
and two anonymous referees gave constructive comments on the manuscript. The work
was supported by the European Union (Human Capital and Mobility Contract No. RB4050PL922765.
article_processing_charge: No
article_type: original
author:
- first_name: Jaroslav
full_name: Piálek, Jaroslav
last_name: Piálek
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Piálek J, Barton NH. The spread of an advantageous allele across a barrier:
the effects of random drift and selection against heterozygotes. Genetics.
1997;145(2):493-504. doi:10.1093/genetics/145.2.493'
apa: 'Piálek, J., & Barton, N. H. (1997). The spread of an advantageous allele
across a barrier: the effects of random drift and selection against heterozygotes.
Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/145.2.493'
chicago: 'Piálek, Jaroslav, and Nicholas H Barton. “The Spread of an Advantageous
Allele across a Barrier: The Effects of Random Drift and Selection against Heterozygotes.”
Genetics. Genetics Society of America, 1997. https://doi.org/10.1093/genetics/145.2.493.'
ieee: 'J. Piálek and N. H. Barton, “The spread of an advantageous allele across
a barrier: the effects of random drift and selection against heterozygotes,” Genetics,
vol. 145, no. 2. Genetics Society of America, pp. 493–504, 1997.'
ista: 'Piálek J, Barton NH. 1997. The spread of an advantageous allele across a
barrier: the effects of random drift and selection against heterozygotes. Genetics.
145(2), 493–504.'
mla: 'Piálek, Jaroslav, and Nicholas H. Barton. “The Spread of an Advantageous Allele
across a Barrier: The Effects of Random Drift and Selection against Heterozygotes.”
Genetics, vol. 145, no. 2, Genetics Society of America, 1997, pp. 493–504,
doi:10.1093/genetics/145.2.493.'
short: J. Piálek, N.H. Barton, Genetics 145 (1997) 493–504.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-02-01T00:00:00Z
date_updated: 2022-08-18T12:34:37Z
day: '01'
doi: 10.1093/genetics/145.2.493
extern: '1'
external_id:
pmid:
- '9071602'
intvolume: ' 145'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/145/2/493/6018085
month: '02'
oa: 1
oa_version: Published Version
page: 493 - 504
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1797'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The spread of an advantageous allele across a barrier: the effects of random
drift and selection against heterozygotes'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 145
year: '1997'
...
---
_id: '4287'
abstract:
- lang: eng
text: 'We evaluate Sewall Wright''s three-phase "shifting balance" theory of evolution,
examining both the theoretical issues and the relevant data from nature and the
laboratory. We conclude that while phases I and II of Wright''s theory (the movement
of populations from one "adaptive peak" to another via drift and selection) can
occur under some conditions, genetic drift is often unnecessary for movement between
peaks. Phase III of the shifting balance, in which adaptations spread from particular
populations to the entire species, faces two major theoretical obstacles: (1)
unlike adaptations favored by simple directional selection, adaptations whose
fixation requires some genetic drift are often prevented from spreading by barriers
to gene flow; and (2) it is difficult to assemble complex adaptations whose constituent
parts arise via peak shifts in different demes. Our review of the data from nature
shows that although there is some evidence for individual phases of the shifting
balance process, there are few empirical observations explained better by Wright''s
three-phase mechanism than by simple mass selection. Similarly, artificial selection
experiments fail to show that selection in subdivided populations produces greater
response than does mass selection in large populations. The complexity of the
shifting balance process and the difficulty of establishing that adaptive valleys
have been crossed by genetic drift make it impossible to test Wright''s claim
that adaptations commonly originate by this process. In view of these problems,
it seems unreasonable to consider the shifting balance process as an important
explanation for the evolution of adaptations. '
acknowledgement: 'We thank the following people for discussion and comments on themanuscript:
S.Barrett,J. Bull, B.Charlesworth, D.Charlesworth, P. DeVries, S.Gavrilets, J. H.Gillespie,
R.K.Grosberg, W.G. Hill, A. A.Hoffmann, M.Kirkpatrick, C.H.Langley, R. C.Lewontin,
J.B. Mallet, M. Noor, L.Nunney, H. A. Orr, T. Prout, M.Slatkin, J.Spofford, W.Stephan,
J. B. Walsh, P. Ward, K. Weber, J. Willis, and M.Zwick. We are especially grateful
to D.J. Futuyma and D.Schemskefor their exhaustive criticism of the manuscript.
Needless to say, not all of these reviewers agree with our ideas. This work was
supported by National Institutes of Health grant GM50355 to JAC, National Science
Foundation grant DEB9527808 to MT, and grants from the Darwin Trust of Edinburgh
and the Biotechnology and Biological Sciences Research Council (GRJI76057,GRIHI09928)
to NHB.'
article_processing_charge: No
article_type: original
author:
- first_name: Jerry
full_name: Coyne, Jerry
last_name: Coyne
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Michael
full_name: Turelli, Michael
last_name: Turelli
citation:
ama: 'Coyne J, Barton NH, Turelli M. Perspective: A critique of Sewall Wright’s
shifting balance theory of evolutionight’s shifting balance theory of evolution.
Evolution; International Journal of Organic Evolution. 1997;51(3):643-671.
doi:10.1111/j.1558-5646.1997.tb03650.x'
apa: 'Coyne, J., Barton, N. H., & Turelli, M. (1997). Perspective: A critique
of Sewall Wright’s shifting balance theory of evolutionight’s shifting balance
theory of evolution. Evolution; International Journal of Organic Evolution.
Wiley-Blackwell. https://doi.org/10.1111/j.1558-5646.1997.tb03650.x'
chicago: 'Coyne, Jerry, Nicholas H Barton, and Michael Turelli. “Perspective: A
Critique of Sewall Wright’s Shifting Balance Theory of Evolutionight’s Shifting
Balance Theory of Evolution.” Evolution; International Journal of Organic Evolution.
Wiley-Blackwell, 1997. https://doi.org/10.1111/j.1558-5646.1997.tb03650.x.'
ieee: 'J. Coyne, N. H. Barton, and M. Turelli, “Perspective: A critique of Sewall
Wright’s shifting balance theory of evolutionight’s shifting balance theory of
evolution,” Evolution; International Journal of Organic Evolution, vol.
51, no. 3. Wiley-Blackwell, pp. 643–671, 1997.'
ista: 'Coyne J, Barton NH, Turelli M. 1997. Perspective: A critique of Sewall Wright’s
shifting balance theory of evolutionight’s shifting balance theory of evolution.
Evolution; International Journal of Organic Evolution. 51(3), 643–671.'
mla: 'Coyne, Jerry, et al. “Perspective: A Critique of Sewall Wright’s Shifting
Balance Theory of Evolutionight’s Shifting Balance Theory of Evolution.” Evolution;
International Journal of Organic Evolution, vol. 51, no. 3, Wiley-Blackwell,
1997, pp. 643–71, doi:10.1111/j.1558-5646.1997.tb03650.x.'
short: J. Coyne, N.H. Barton, M. Turelli, Evolution; International Journal of Organic
Evolution 51 (1997) 643–671.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-06-01T00:00:00Z
date_updated: 2022-08-18T09:48:43Z
day: '01'
doi: 10.1111/j.1558-5646.1997.tb03650.x
extern: '1'
external_id:
pmid:
- '28568586'
intvolume: ' 51'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1558-5646.1997.tb03650.x
month: '06'
oa: 1
oa_version: Published Version
page: 643 - 671
pmid: 1
publication: Evolution; International Journal of Organic Evolution
publication_identifier:
issn:
- 0014-3820
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1791'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Perspective: A critique of Sewall Wright''s shifting balance theory of evolutionight''s
shifting balance theory of evolution'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 51
year: '1997'
...
---
_id: '4288'
abstract:
- lang: eng
text: We measured the heterozygous effects on net fitness of a sample of 12 wild-type
third chromosomes in D. melanogaster. Effects on fitness were assessed by competing
the wild-type chromosomes against balancer chromosomes, to prevent the production
of recombinants. The measurements were carried out in the population cage environment
in which the life history had been evolving, in an undisturbed population with
overlapping generations, and replicated measurements were made on each chromosome
to control for confounding effects such as mutation accumulation. We found significant
variation among the wild type chromosomes in their additive genetic effect on
net fitness. The system provides an opportunity to obtain an accurate estimate
of the distribution of heterozygous effects on net fitness, the contribution of
different fitness components including male mating success, and the role of intra-chromosomal
epistasis in fitness variation.
acknowledgement: We thank John Sved for helpful discussions in the planningstages
of the project, Brian Charlesworth, Alexei Kondrashov, Trudy Mackay and Steve Stearns
for commentson the manuscript, SERC, BBSRC, the Darwin Trust andthe Royal Society
for Financial support, and Ms N. Goorneyfor technical assistance
article_processing_charge: No
article_type: original
author:
- first_name: Kevin
full_name: Fowler, Kevin
last_name: Fowler
- first_name: Colin
full_name: Semple, Colin
last_name: Semple
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Linda
full_name: Partridge, Linda
last_name: Partridge
citation:
ama: Fowler K, Semple C, Barton NH, Partridge L. Genetic variation for total fitness
in Drosophila melanogaster. Proceedings of the Royal Society of London Series
B Biological Sciences. 1997;264(1379):191-199. doi:10.1098/rspb.1997.0027
apa: Fowler, K., Semple, C., Barton, N. H., & Partridge, L. (1997). Genetic
variation for total fitness in Drosophila melanogaster. Proceedings of the
Royal Society of London Series B Biological Sciences. The Royal Society. https://doi.org/10.1098/rspb.1997.0027
chicago: Fowler, Kevin, Colin Semple, Nicholas H Barton, and Linda Partridge. “Genetic
Variation for Total Fitness in Drosophila Melanogaster.” Proceedings of the
Royal Society of London Series B Biological Sciences. The Royal Society, 1997.
https://doi.org/10.1098/rspb.1997.0027.
ieee: K. Fowler, C. Semple, N. H. Barton, and L. Partridge, “Genetic variation for
total fitness in Drosophila melanogaster,” Proceedings of the Royal Society
of London Series B Biological Sciences, vol. 264, no. 1379. The Royal Society,
pp. 191–199, 1997.
ista: Fowler K, Semple C, Barton NH, Partridge L. 1997. Genetic variation for total
fitness in Drosophila melanogaster. Proceedings of the Royal Society of London
Series B Biological Sciences. 264(1379), 191–199.
mla: Fowler, Kevin, et al. “Genetic Variation for Total Fitness in Drosophila Melanogaster.”
Proceedings of the Royal Society of London Series B Biological Sciences,
vol. 264, no. 1379, The Royal Society, 1997, pp. 191–99, doi:10.1098/rspb.1997.0027.
short: K. Fowler, C. Semple, N.H. Barton, L. Partridge, Proceedings of the Royal
Society of London Series B Biological Sciences 264 (1997) 191–199.
date_created: 2018-12-11T12:08:03Z
date_published: 1997-02-22T00:00:00Z
date_updated: 2022-08-18T11:31:58Z
day: '22'
doi: 10.1098/rspb.1997.0027
extern: '1'
external_id:
pmid:
- '9061969'
intvolume: ' 264'
issue: '1379'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1688253/
month: '02'
oa: 1
oa_version: Published Version
page: 191 - 199
pmid: 1
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0962-8452
publication_status: published
publisher: The Royal Society
publist_id: '1792'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic variation for total fitness in Drosophila melanogaster
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 264
year: '1997'
...
---
_id: '4289'
abstract:
- lang: eng
text: A worldwide survey of polymorphic molecular markers shows that the human population
is genetically homogeneous, in close agreement with evidence from quite different
genes and traits.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Population genetics: A new apportionment of human diversity. Current
Biology. 1997;7(12):757-758. doi:10.1016/S0960-9822(06)00397-6'
apa: 'Barton, N. H. (1997). Population genetics: A new apportionment of human diversity.
Current Biology. Cell Press. https://doi.org/10.1016/S0960-9822(06)00397-6'
chicago: 'Barton, Nicholas H. “Population Genetics: A New Apportionment of Human
Diversity.” Current Biology. Cell Press, 1997. https://doi.org/10.1016/S0960-9822(06)00397-6.'
ieee: 'N. H. Barton, “Population genetics: A new apportionment of human diversity,”
Current Biology, vol. 7, no. 12. Cell Press, pp. 757–758, 1997.'
ista: 'Barton NH. 1997. Population genetics: A new apportionment of human diversity.
Current Biology. 7(12), 757–758.'
mla: 'Barton, Nicholas H. “Population Genetics: A New Apportionment of Human Diversity.”
Current Biology, vol. 7, no. 12, Cell Press, 1997, pp. 757–58, doi:10.1016/S0960-9822(06)00397-6.'
short: N.H. Barton, Current Biology 7 (1997) 757–758.
date_created: 2018-12-11T12:08:04Z
date_published: 1997-12-01T00:00:00Z
date_updated: 2022-08-17T13:07:08Z
day: '01'
doi: 10.1016/S0960-9822(06)00397-6
extern: '1'
intvolume: ' 7'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0960982206003976?via%3Dihub
month: '12'
oa: 1
oa_version: Published Version
page: 757 - 758
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Cell Press
publist_id: '1788'
quality_controlled: '1'
status: public
title: 'Population genetics: A new apportionment of human diversity'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '1997'
...
---
_id: '2582'
abstract:
- lang: eng
text: 'Neurotransmission in the hippocampus is modulated variously through presynaptic
metabotropic glutamate receptors (mGluRs). To establish the precise localization
of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies
for eight mGluRs (mGluR1-mGluR8) for immunohistochemistry combined with lesioning
of the three major hippocampal pathways: the perforant path, mossy fiber, and
Schaffer collateral. Immunoreactivity for group II (mGluR2) and group III (mGluR4a,
mGluR7a, mGluR7b, and mGluR8) mGluRs was predominantly localized to presynaptic
elements, whereas that for group I mGluRs (mGluR1 and mGluR5) was localized to
postsynaptic elements. The medial perforant path was strongly immunoreactive for
mGluR2 and mGluR7a throughout the hippocampus, and the lateral perforant path
was prominently immunoreactive for mGluR8 in the dentate gyrus and CA3 area. The
messy fiber was labeled for mGluR2, mGluR7a, and mGluR7b, whereas the Schaffer
collateral was labeled only for mGluR7a. Electron microscopy further revealed
the spatial segregation of group II and group III mGluRs within presynaptic elements.
Immunolabeling for the group III receptors was predominantly observed in presynaptic
active zones of asymmetrical and symmetrical synapses, whereas that for the group
II receptor (mGluR2) was found in preterminal rather than terminal portions of
axons. Target cell-specific segregation of receptors, first reported for mGluR7a
(Shigemoto et al., 1996), was also apparent for the other group III mGluRs, suggesting
that transmitter release is differentially regulated by 2-amino- 4-phosphonobutyrate-sensitive
mGluRs in individual synapses on single axons according to the identity of postsynaptic
neurons.'
acknowledgement: This work was supported by research grants from the Inamori Foundation
and the Ministry of Education, Science, Sports and Culture of Japan. We thank Peter
Somogyi for helpful discussion, David Roberts for technical assistance, and Akira
Uesugi for photographic assistance. We are grateful to Atsu Aiba, David Hampson,
John Roder, and Herman van der Putten for providing us with mGluR1-, mGluR4-, mGluR5-,
and mGluR7-deficient mice, respectively, and to Corrado Corti and Francesco Ferraguti
for sharing rat mGluR8 cDNA and unpublished results.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Eiki
full_name: Wada, Eiki
last_name: Wada
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Kinoshita A, Wada E, et al. Differential presynaptic localization
of metabotropic glutamate receptor subtypes in the rat hippocampus. Journal
of Neuroscience. 1997;17(19):7503-7522. doi:10.1523/JNEUROSCI.17-19-07503.1997
apa: Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M.,
… Mizuno, N. (1997). Differential presynaptic localization of metabotropic glutamate
receptor subtypes in the rat hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997
chicago: Shigemoto, Ryuichi, Ayae Kinoshita, Eiki Wada, Sakashi Nomura, Hitoshi
Ohishi, Masahiko Takada, Peter Flor, et al. “Differential Presynaptic Localization
of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997.
ieee: R. Shigemoto et al., “Differential presynaptic localization of metabotropic
glutamate receptor subtypes in the rat hippocampus,” Journal of Neuroscience,
vol. 17, no. 19. Society for Neuroscience, pp. 7503–7522, 1997.
ista: Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor P, Neki
A, Abe T, Nakanishi S, Mizuno N. 1997. Differential presynaptic localization of
metabotropic glutamate receptor subtypes in the rat hippocampus. Journal of Neuroscience.
17(19), 7503–7522.
mla: Shigemoto, Ryuichi, et al. “Differential Presynaptic Localization of Metabotropic
Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal of Neuroscience,
vol. 17, no. 19, Society for Neuroscience, 1997, pp. 7503–22, doi:10.1523/JNEUROSCI.17-19-07503.1997.
short: R. Shigemoto, A. Kinoshita, E. Wada, S. Nomura, H. Ohishi, M. Takada, P.
Flor, A. Neki, T. Abe, S. Nakanishi, N. Mizuno, Journal of Neuroscience 17 (1997)
7503–7522.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-22T11:32:01Z
day: '01'
doi: 10.1523/JNEUROSCI.17-19-07503.1997
extern: '1'
external_id:
pmid:
- '9295396'
intvolume: ' 17'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573434/
month: '10'
oa: 1
oa_version: Published Version
page: 7503 - 7522
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4317'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential presynaptic localization of metabotropic glutamate receptor subtypes
in the rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '11767'
abstract:
- lang: eng
text: We give a linear-time algorithm for single-source shortest paths in planar
graphs with nonnegative edge-lengths. Our algorithm also yields a linear-time
algorithm for maximum flow in a planar graph with the source and sink on the same
face. For the case where negative edge-lengths are allowed, we give an algorithm
requiringO(n4/3 log(nL)) time, whereLis the absolute value of the most negative
length. This algorithm can be used to obtain similar bounds for computing a feasible
flow in a planar network, for finding a perfect matching in a planar bipartite
graph, and for finding a maximum flow in a planar graph when the source and sink
are not on the same face. We also give parallel and dynamic versions of these
algorithms.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Philip
full_name: Klein, Philip
last_name: Klein
- first_name: Satish
full_name: Rao, Satish
last_name: Rao
- first_name: Sairam
full_name: Subramanian, Sairam
last_name: Subramanian
citation:
ama: Henzinger MH, Klein P, Rao S, Subramanian S. Faster shortest-path algorithms
for planar graphs. Journal of Computer and System Sciences. 1997;55(1):3-23.
doi:10.1006/jcss.1997.1493
apa: Henzinger, M. H., Klein, P., Rao, S., & Subramanian, S. (1997). Faster
shortest-path algorithms for planar graphs. Journal of Computer and System
Sciences. Elsevier. https://doi.org/10.1006/jcss.1997.1493
chicago: Henzinger, Monika H, Philip Klein, Satish Rao, and Sairam Subramanian.
“Faster Shortest-Path Algorithms for Planar Graphs.” Journal of Computer and
System Sciences. Elsevier, 1997. https://doi.org/10.1006/jcss.1997.1493.
ieee: M. H. Henzinger, P. Klein, S. Rao, and S. Subramanian, “Faster shortest-path
algorithms for planar graphs,” Journal of Computer and System Sciences,
vol. 55, no. 1. Elsevier, pp. 3–23, 1997.
ista: Henzinger MH, Klein P, Rao S, Subramanian S. 1997. Faster shortest-path algorithms
for planar graphs. Journal of Computer and System Sciences. 55(1), 3–23.
mla: Henzinger, Monika H., et al. “Faster Shortest-Path Algorithms for Planar Graphs.”
Journal of Computer and System Sciences, vol. 55, no. 1, Elsevier, 1997,
pp. 3–23, doi:10.1006/jcss.1997.1493.
short: M.H. Henzinger, P. Klein, S. Rao, S. Subramanian, Journal of Computer and
System Sciences 55 (1997) 3–23.
date_created: 2022-08-08T12:28:45Z
date_published: 1997-08-01T00:00:00Z
date_updated: 2022-09-12T10:46:21Z
day: '01'
doi: 10.1006/jcss.1997.1493
extern: '1'
intvolume: ' 55'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1006/jcss.1997.1493
month: '08'
oa: 1
oa_version: Published Version
page: 3-23
publication: Journal of Computer and System Sciences
publication_identifier:
issn:
- 0022-0000
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Faster shortest-path algorithms for planar graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '1997'
...
---
_id: '11849'
abstract:
- lang: eng
text: "This paper describes the DIGlTAL Continuous Profiling Infrastmcture, a sampling-based
profiling system designed to run continuously on production systems. The system
supports multiprocessors, works on unmodified executable& and collects profiles
for entire systems, including user programs, shared libraries, and the operating
system kernel. Samples are collected at a high rate (over 5200 samples/secper333-MHz
processor), yet with low overhead (l-3% slowdown for most workloads). Analysis
tools supplied with the profiling system use the sample data to produce an accurate
accounting, down to the level of pipeline stalls incurred by individual instructions,
of where time is being spent. When instructions incur stalls, the tools identify
possible reasons, such as cache misses, branch mispredictions, and functional
unit contention. The fine-grained instruction-level analysis guides users and
automated optimizers to the causes of performance\r\nproblems and provides important
insights for fixing them. "
article_processing_charge: No
article_type: original
author:
- first_name: Jennifer M.
full_name: Anderson, Jennifer M.
last_name: Anderson
- first_name: Lance M.
full_name: Berc, Lance M.
last_name: Berc
- first_name: Jeffrey
full_name: Dean, Jeffrey
last_name: Dean
- first_name: Sanjay
full_name: Ghemawat, Sanjay
last_name: Ghemawat
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Shun-Tak A.
full_name: Leung, Shun-Tak A.
last_name: Leung
- first_name: Richard L.
full_name: Sites, Richard L.
last_name: Sites
- first_name: Mark T.
full_name: Vandevoorde, Mark T.
last_name: Vandevoorde
- first_name: Carl A.
full_name: Waldspurger, Carl A.
last_name: Waldspurger
- first_name: William E.
full_name: Weihl, William E.
last_name: Weihl
citation:
ama: 'Anderson JM, Berc LM, Dean J, et al. Continuous profiling: Where have all
the cycles gone? ACM SIGOPS Operating Systems Review. 1997;31(5):1-14.
doi:10.1145/269005.266637'
apa: 'Anderson, J. M., Berc, L. M., Dean, J., Ghemawat, S., Henzinger, M. H., Leung,
S.-T. A., … Weihl, W. E. (1997). Continuous profiling: Where have all the cycles
gone? ACM SIGOPS Operating Systems Review. Association for Computing Machinery.
https://doi.org/10.1145/269005.266637'
chicago: 'Anderson, Jennifer M., Lance M. Berc, Jeffrey Dean, Sanjay Ghemawat, Monika
H Henzinger, Shun-Tak A. Leung, Richard L. Sites, Mark T. Vandevoorde, Carl A.
Waldspurger, and William E. Weihl. “Continuous Profiling: Where Have All the Cycles
Gone?” ACM SIGOPS Operating Systems Review. Association for Computing Machinery,
1997. https://doi.org/10.1145/269005.266637.'
ieee: 'J. M. Anderson et al., “Continuous profiling: Where have all the cycles
gone?,” ACM SIGOPS Operating Systems Review, vol. 31, no. 5. Association
for Computing Machinery, pp. 1–14, 1997.'
ista: 'Anderson JM, Berc LM, Dean J, Ghemawat S, Henzinger MH, Leung S-TA, Sites
RL, Vandevoorde MT, Waldspurger CA, Weihl WE. 1997. Continuous profiling: Where
have all the cycles gone? ACM SIGOPS Operating Systems Review. 31(5), 1–14.'
mla: 'Anderson, Jennifer M., et al. “Continuous Profiling: Where Have All the Cycles
Gone?” ACM SIGOPS Operating Systems Review, vol. 31, no. 5, Association
for Computing Machinery, 1997, pp. 1–14, doi:10.1145/269005.266637.'
short: J.M. Anderson, L.M. Berc, J. Dean, S. Ghemawat, M.H. Henzinger, S.-T.A. Leung,
R.L. Sites, M.T. Vandevoorde, C.A. Waldspurger, W.E. Weihl, ACM SIGOPS Operating
Systems Review 31 (1997) 1–14.
date_created: 2022-08-16T07:07:03Z
date_published: 1997-12-01T00:00:00Z
date_updated: 2023-02-21T16:30:27Z
day: '01'
doi: 10.1145/269005.266637
extern: '1'
intvolume: ' 31'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1145/269005.266637
month: '12'
oa: 1
oa_version: Published Version
page: 1-14
publication: ACM SIGOPS Operating Systems Review
publication_identifier:
issn:
- 0163-5980
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
related_material:
record:
- id: '11849'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: 'Continuous profiling: Where have all the cycles gone?'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 31
year: '1997'
...
---
_id: '6161'
abstract:
- lang: eng
text: 'The tra-1 gene is a terminal regulator of somatic sex in Caenorhabditis elegans:
high tra-1 activity elicits female development, low tra-1 activity elicits male
development. To investigate the function and evolution of tra- 1, we examined
the tra-1 gene from the closely related nematode C. briggsae. Ce-tra-1 and Cb-tra-1
are unusually divergent. Each gene generates two transcripts, but only one of
these is present in both species. This common transcript encodes TRA-1A, which
shows only 44% amino acid identity between the species, a figure much lower than
that for previously compared genes. A Cb-tra-1 transgene rescues many tissues
of tra-1(null) mutants of C. elegans but not the somatic gonad or germ line. This
transgene also causes nongonadal feminization of XO animals, indicating incorrect
sexual regulation. Alignment of Ce-TRA-1A and Cb-TRA-1A defined several conserved
regions likely to be important for tra-1 function. The phenotype differences between
Ce-tra- 1(null) mutants rescued by Cb-tra-1 transgenes and wild-type C. elegans
indicate significant divergence of regulatory regions. These molecular and functional
studies suggest that evolution of sex determination in nematodes is rapid and
genetically complex.'
author:
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
- first_name: J.
full_name: Hodgkin, J.
last_name: Hodgkin
citation:
ama: 'de Bono M, Hodgkin J. Evolution of sex determination in Caenorhabditis: Unusually
high divergence of tra-1 and its functional consequences. Genetics. 1996;144(2):587-595.'
apa: 'de Bono, M., & Hodgkin, J. (1996). Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences. Genetics.
Genetics Society of America.'
chicago: 'Bono, Mario de, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis:
Unusually High Divergence of Tra-1 and Its Functional Consequences.” Genetics.
Genetics Society of America, 1996.'
ieee: 'M. de Bono and J. Hodgkin, “Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences,” Genetics,
vol. 144, no. 2. Genetics Society of America, pp. 587–595, 1996.'
ista: 'de Bono M, Hodgkin J. 1996. Evolution of sex determination in Caenorhabditis:
Unusually high divergence of tra-1 and its functional consequences. Genetics.
144(2), 587–595.'
mla: 'de Bono, Mario, and J. Hodgkin. “Evolution of Sex Determination in Caenorhabditis:
Unusually High Divergence of Tra-1 and Its Functional Consequences.” Genetics,
vol. 144, no. 2, Genetics Society of America, 1996, pp. 587–95.'
short: M. de Bono, J. Hodgkin, Genetics 144 (1996) 587–595.
date_created: 2019-03-21T11:50:37Z
date_published: 1996-10-01T00:00:00Z
date_updated: 2021-01-12T08:06:28Z
day: '01'
extern: '1'
external_id:
pmid:
- '8889522'
intvolume: ' 144'
issue: '2'
keyword:
- amino acid sequence
- article
- caenorhabditis elegans
- evolution
- genetic variability
- nonhuman
- priority journal
- sex determination
- Amino Acid Sequence
- Animals
- Animals
- Genetically Modified
- Base Sequence
- Caenorhabditis
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- DNA
- Helminth
- DNA-Binding Proteins
- Evolution
- Molecular
- Female
- Helminth Proteins
- Membrane Proteins
- Molecular Sequence Data
- Mutagenesis
- RNA
- Messenger
- Sequence Homology
- Amino Acid
- Sex Determination (Analysis)
- Transcription Factors
- Transgenes
- Turner Syndrome
- Animalia
- Caenorhabditis
- Caenorhabditis briggsae
- Caenorhabditis elegans
- Nematoda
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1207552/
month: '10'
oa: 1
oa_version: Published Version
page: 587-595
pmid: 1
publication: Genetics
publication_identifier:
issn:
- '00166731'
publication_status: published
publisher: Genetics Society of America
quality_controlled: '1'
status: public
title: 'Evolution of sex determination in Caenorhabditis: Unusually high divergence
of tra-1 and its functional consequences'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 144
year: '1996'
...
---
_id: '3756'
abstract:
- lang: eng
text: 'In many eukaryotic cells going through M-phase, a bipolar spindle is formed
by microtubules nucleated from centrosomes. These microtubules, in addition to
being `''captured” by kinetochores, may be stabilized by chromatin in two different
ways: short-range stabilization effects may affect microtubules in close contact
with the chromatin, while long-range stabilization effects may `''guide” microtubule
growth towards the chromatin (e.g., by introducing a diffusive gradient of an
enzymatic activity that affects microtubule assembly). Here, we use both meiotic
and mitotic extracts from Xenopus laevis eggs to study microtubule aster formation
and microtubule dynamics in the presence of chromatin. In `''low-speed” meiotic
extracts, in the presence of salmon sperm chromatin, we find that short-range
stabilization effects lead to a strong anisotropy of the microtubule asters. Analysis
of the dynamic parameters of microtubule growth shows that this anisotropy arises
from a decrease in the catastrophe frequency, an increase in the rescue frequency
and a decrease in the growth velocity. In this system we also find evidence for
long-range `''guidance” effects, which lead to a weak anisotropy of the asters.
Statistically relevant results on these long-range effects are obtained in `''high-speed”
mitotic extracts in the presence of artificially constructed chromatin stripes.
We find that aster anisotropy is biased in the direction of the chromatin and
that the catastrophe frequency is reduced in its vicinity. In this system we also
find a surprising dependence of the catastrophe and the rescue frequencies on
the length of microtubules nucleated from centrosomes: the catastrophe frequency
increases and the rescue frequency decreases with microtubule length.'
acknowledgement: "We would like to thank T. Holy and T. Mitchison for providing us
with centrosomes; M. Glotzer and T. Mitchison for giving us the plasmid for A90
cyclin B; J. Stock and members of his laboratory for help with biochemical preparations;
R. Zimmerman for help with the biotinylation of DNA; J. Shepard for help with the
patterning of surfaces; D. Tsui for use\r\nof his clean room facility, and D. Fygenson,
T. Holy, E. Karsenti, E. Kennedy, A. Levine, T. Mitchison, and G. Waters for valuable
discussions, constant encouragement and technical help. This work was partially
supported by the National Institutes of Health (Grant No. GM-50712) and the Human
Frontier Science Program."
article_processing_charge: No
article_type: original
author:
- first_name: Marileen
full_name: Dogterom, Marileen
last_name: Dogterom
- first_name: M.
full_name: Felix, M.
last_name: Felix
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Stanislas
full_name: Leibler, Stanislas
last_name: Leibler
citation:
ama: 'Dogterom M, Felix M, Guet CC, Leibler S. Influence of M-phase chromatin on
the anisotropy of microtubule asters. Journal of Cell Biology. 1996;133(1):125-140.
doi:doi: 10.1083/jcb.133.1.125
'
apa: 'Dogterom, M., Felix, M., Guet, C. C., & Leibler, S. (1996). Influence
of M-phase chromatin on the anisotropy of microtubule asters. Journal of Cell
Biology. Rockefeller University Press. https://doi.org/doi: 10.1083/jcb.133.1.125 '
chicago: 'Dogterom, Marileen, M. Felix, Calin C Guet, and Stanislas Leibler. “Influence
of M-Phase Chromatin on the Anisotropy of Microtubule Asters.” Journal of Cell
Biology. Rockefeller University Press, 1996. https://doi.org/doi: 10.1083/jcb.133.1.125 .'
ieee: M. Dogterom, M. Felix, C. C. Guet, and S. Leibler, “Influence of M-phase chromatin
on the anisotropy of microtubule asters,” Journal of Cell Biology, vol.
133, no. 1. Rockefeller University Press, pp. 125–140, 1996.
ista: Dogterom M, Felix M, Guet CC, Leibler S. 1996. Influence of M-phase chromatin
on the anisotropy of microtubule asters. Journal of Cell Biology. 133(1), 125–140.
mla: 'Dogterom, Marileen, et al. “Influence of M-Phase Chromatin on the Anisotropy
of Microtubule Asters.” Journal of Cell Biology, vol. 133, no. 1, Rockefeller
University Press, 1996, pp. 125–40, doi:doi: 10.1083/jcb.133.1.125 .'
short: M. Dogterom, M. Felix, C.C. Guet, S. Leibler, Journal of Cell Biology 133
(1996) 125–140.
date_created: 2018-12-11T12:05:00Z
date_published: 1996-01-01T00:00:00Z
date_updated: 2022-08-09T14:20:13Z
day: '01'
doi: 'doi: 10.1083/jcb.133.1.125 '
extern: '1'
external_id:
pmid:
- '8601601'
intvolume: ' 133'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2120784/
month: '01'
oa: 1
oa_version: Published Version
page: 125 - 140
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
publist_id: '2473'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Influence of M-phase chromatin on the anisotropy of microtubule asters
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 133
year: '1996'
...
---
_id: '4025'
abstract:
- lang: eng
text: Questions of chemical reactivity can often be cast as questions of molecular
geometry. Common geometric models for proteins and other molecules are the space-filling
diagram, the solvent accessible surface and the molecular surface. In this paper
we present a new approach to triangulating the surface of a molecule under the
three models, which is fast, robust, and results in topologically correct triangulations.
Our computations are based on a simplicial complex dual to the molecule models.
All proposed algorithms are parallelizable.
acknowledgement: 'The research of both authors is partially supported by the Office
of Naval Research. Herbert Edelsbrunner is also supported through the Alan T. Waterman
award, grant CCR-9118874. '
article_processing_charge: No
article_type: original
author:
- first_name: Nataraj
full_name: Akkiraju, Nataraj
last_name: Akkiraju
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
citation:
ama: Akkiraju N, Edelsbrunner H. Triangulating the surface of a molecule. Discrete
Applied Mathematics. 1996;71(1-3):5-22. doi:10.1016/S0166-218X(96)00054-6
apa: Akkiraju, N., & Edelsbrunner, H. (1996). Triangulating the surface of a
molecule. Discrete Applied Mathematics. Elsevier. https://doi.org/10.1016/S0166-218X(96)00054-6
chicago: Akkiraju, Nataraj, and Herbert Edelsbrunner. “Triangulating the Surface
of a Molecule.” Discrete Applied Mathematics. Elsevier, 1996. https://doi.org/10.1016/S0166-218X(96)00054-6.
ieee: N. Akkiraju and H. Edelsbrunner, “Triangulating the surface of a molecule,”
Discrete Applied Mathematics, vol. 71, no. 1–3. Elsevier, pp. 5–22, 1996.
ista: Akkiraju N, Edelsbrunner H. 1996. Triangulating the surface of a molecule.
Discrete Applied Mathematics. 71(1–3), 5–22.
mla: Akkiraju, Nataraj, and Herbert Edelsbrunner. “Triangulating the Surface of
a Molecule.” Discrete Applied Mathematics, vol. 71, no. 1–3, Elsevier,
1996, pp. 5–22, doi:10.1016/S0166-218X(96)00054-6.
short: N. Akkiraju, H. Edelsbrunner, Discrete Applied Mathematics 71 (1996) 5–22.
date_created: 2018-12-11T12:06:30Z
date_published: 1996-12-05T00:00:00Z
date_updated: 2022-08-09T14:06:12Z
day: '05'
doi: 10.1016/S0166-218X(96)00054-6
extern: '1'
intvolume: ' 71'
issue: 1-3
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0166218X96000546?via%3Dihub
month: '12'
oa: 1
oa_version: Published Version
page: 5 - 22
publication: Discrete Applied Mathematics
publication_identifier:
issn:
- 0166-218X
publication_status: published
publisher: Elsevier
publist_id: '2102'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triangulating the surface of a molecule
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 71
year: '1996'
...
---
_id: '4030'
acknowledgement: article M-Pos412
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Shankar
full_name: Subramaniam, Shankar
last_name: Subramaniam
citation:
ama: Liang J, Edelsbrunner H, Subramaniam S. Effects of Molecular Shape Representations
on Boundary Element Method for Protein Electrostatics Computations. Vol 70.
Cell Press; 1996:A224-A224. doi:10.1016/S0006-3495(96)79664-9
apa: Liang, J., Edelsbrunner, H., & Subramaniam, S. (1996). Effects of molecular
shape representations on boundary element method for protein electrostatics computations.
Fortieth Annual Meeting (Vol. 70, pp. A224–A224). Cell Press. https://doi.org/10.1016/S0006-3495(96)79664-9
chicago: Liang, Jie, Herbert Edelsbrunner, and Shankar Subramaniam. Effects of
Molecular Shape Representations on Boundary Element Method for Protein Electrostatics
Computations. Fortieth Annual Meeting. Vol. 70. Cell Press, 1996. https://doi.org/10.1016/S0006-3495(96)79664-9.
ieee: J. Liang, H. Edelsbrunner, and S. Subramaniam, Effects of molecular shape
representations on boundary element method for protein electrostatics computations,
vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A224–A224.
ista: Liang J, Edelsbrunner H, Subramaniam S. 1996. Effects of molecular shape representations
on boundary element method for protein electrostatics computations, Cell Press,p.
mla: Liang, Jie, et al. “Effects of Molecular Shape Representations on Boundary
Element Method for Protein Electrostatics Computations.” Fortieth Annual Meeting,
vol. 70, no. 2, Part 2, Cell Press, 1996, pp. A224–A224, doi:10.1016/S0006-3495(96)79664-9.
short: J. Liang, H. Edelsbrunner, S. Subramaniam, Effects of Molecular Shape Representations
on Boundary Element Method for Protein Electrostatics Computations, Cell Press,
1996.
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-19T00:00:00Z
date_updated: 2022-08-08T10:22:38Z
day: '19'
doi: 10.1016/S0006-3495(96)79664-9
extern: '1'
intvolume: ' 70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0006349596796649?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A224 - A224
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2097'
status: public
title: Effects of molecular shape representations on boundary element method for protein
electrostatics computations
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...
---
_id: '4031'
acknowledgement: article W-AM-L6
article_processing_charge: No
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sudhakar
full_name: Pamidghantam, Sudhakar
last_name: Pamidghantam
- first_name: Shankar
full_name: Subramaniam, Shankar
last_name: Subramaniam
citation:
ama: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. Analytical Method
for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets. Vol 70.
Cell Press; 1996:A377-A377. doi:10.1016/S0006-3495(96)79670-4'
apa: 'Liang, J., Edelsbrunner, H., Pamidghantam, S., & Subramaniam, S. (1996).
Analytical method for molecular shapes: Area, volume, cavities, interface and
pockets. Fortieth Annual Meeting (Vol. 70, pp. A377–A377). Cell Press.
https://doi.org/10.1016/S0006-3495(96)79670-4'
chicago: 'Liang, Jie, Herbert Edelsbrunner, Sudhakar Pamidghantam, and Shankar Subramaniam.
Analytical Method for Molecular Shapes: Area, Volume, Cavities, Interface and
Pockets. Fortieth Annual Meeting. Vol. 70. Cell Press, 1996. https://doi.org/10.1016/S0006-3495(96)79670-4.'
ieee: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, and S. Subramaniam, Analytical
method for molecular shapes: Area, volume, cavities, interface and pockets,
vol. 70, no. 2, Part 2. Cell Press, 1996, pp. A377–A377.'
ista: 'Liang J, Edelsbrunner H, Pamidghantam S, Subramaniam S. 1996. Analytical
method for molecular shapes: Area, volume, cavities, interface and pockets, Cell
Press,p.'
mla: 'Liang, Jie, et al. “Analytical Method for Molecular Shapes: Area, Volume,
Cavities, Interface and Pockets.” Fortieth Annual Meeting, vol. 70, no.
2, Part 2, Cell Press, 1996, pp. A377–A377, doi:10.1016/S0006-3495(96)79670-4.'
short: 'J. Liang, H. Edelsbrunner, S. Pamidghantam, S. Subramaniam, Analytical Method
for Molecular Shapes: Area, Volume, Cavities, Interface and Pockets, Cell Press,
1996.'
date_created: 2018-12-11T12:06:32Z
date_published: 1996-02-21T00:00:00Z
date_updated: 2022-08-08T10:21:56Z
day: '21'
doi: 10.1016/S0006-3495(96)79670-4
extern: '1'
intvolume: ' 70'
issue: 2, Part 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0006349596796704?via%3Dihub
month: '02'
oa: 1
oa_version: None
page: A377 - A377
publication: Fortieth Annual Meeting
publication_status: published
publisher: Cell Press
publist_id: '2098'
status: public
title: 'Analytical method for molecular shapes: Area, volume, cavities, interface
and pockets'
type: conference_poster
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 70
year: '1996'
...