---
_id: '2865'
abstract:
- lang: eng
text: 'Although cytokinins (CKs) affect a number of processes connected with chloroplasts,
it has never been rigorously proven that chloroplasts contain CKs. We isolated
intact chloroplasts from tobacco (Nicotiana tabacum L. cv SR1) and wheat (Triticum
aestivum L. cv Ritmo) leaves and determined their CKs by liquid chromatography/tandem
mass spectroscopy. Chloroplasts from both species contained a whole spectrum of
CKs, including free bases (zeatin and isopentenyladenine), ribosides (zeatin riboside,
and isopentenyladenosine), ribotides (isopentenyladenosine-5′-monophosphate, zeatin
riboside-5′-monophosphate, and dihydrozeatin riboside-5′-monophosphate), and N-glucosides
(zeatin-N 9-glucoside, dihydrozeatin-N 9-glucoside, zeatin-N 7-glucoside, and
isopentenyladenine-N-glucosides). In chloroplasts there was a moderately higher
relative amount of bases, ribosides, and ribotides than in leaves, and a significantly
increased level ofN 9-glucosides of zeatin and dihydrozeatin. Tobacco and wheat
chloroplasts were prepared from leaves at the end of either a dark or light period.
After a dark period, chloroplasts accumulated more CKs than after a light period.
The differences were moderate for free bases and ribosides, but highly significant
for glucosides. Tobacco chloroplasts from dark-treated leaves contained zeatin
riboside-O-glucoside and dihydrozeatin riboside-O-glucoside, as well as a relatively
high CK oxidase activity. These data show that chloroplasts contain a whole spectrum
of CKs and the enzymatic activity necessary for their metabolism. '
acknowledgement: The authors thank Prof. Dennis Baker (Wye College, London) and Dr.
Laura Zonia (Institute of Experimental Botany, Prague) for language correction of
the manuscript and Prof. Miroslav Kamínek (Institute of Experimental Botany, Prague)
for critical reading of the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Erwin
full_name: Witters, Erwin
last_name: Witters
- first_name: Walter
full_name: Van Dongen, Walter
last_name: Van Dongen
- first_name: Jan
full_name: Kolář, Jan
last_name: Kolář
- first_name: Václav
full_name: Motyka, Václav
last_name: Motyka
- first_name: Břetislav
full_name: Brzobohatý, Břetislav
last_name: Brzobohatý
- first_name: Henri
full_name: Van Onckelen, Henri
last_name: Van Onckelen
- first_name: Ivana
full_name: Macháčková, Ivana
last_name: Macháčková
citation:
ama: Benková E, Witters E, Van Dongen W, et al. Cytokinins in tobacco and wheat
chloroplasts. Occurrence and changes due to light/dark treatment. Plant Physiology.
1999;121(1):245-251. doi:10.1104/pp.121.1.245
apa: Benková, E., Witters, E., Van Dongen, W., Kolář, J., Motyka, V., Brzobohatý,
B., … Macháčková, I. (1999). Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment. Plant Physiology. American Society
of Plant Biologists. https://doi.org/10.1104/pp.121.1.245
chicago: Benková, Eva, Erwin Witters, Walter Van Dongen, Jan Kolář, Václav Motyka,
Břetislav Brzobohatý, Henri Van Onckelen, and Ivana Macháčková. “Cytokinins in
Tobacco and Wheat Chloroplasts. Occurrence and Changes Due to Light/Dark Treatment.”
Plant Physiology. American Society of Plant Biologists, 1999. https://doi.org/10.1104/pp.121.1.245.
ieee: E. Benková et al., “Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment,” Plant Physiology, vol. 121, no.
1. American Society of Plant Biologists, pp. 245–251, 1999.
ista: Benková E, Witters E, Van Dongen W, Kolář J, Motyka V, Brzobohatý B, Van Onckelen
H, Macháčková I. 1999. Cytokinins in tobacco and wheat chloroplasts. Occurrence
and changes due to light/dark treatment. Plant Physiology. 121(1), 245–251.
mla: Benková, Eva, et al. “Cytokinins in Tobacco and Wheat Chloroplasts. Occurrence
and Changes Due to Light/Dark Treatment.” Plant Physiology, vol. 121, no.
1, American Society of Plant Biologists, 1999, pp. 245–51, doi:10.1104/pp.121.1.245.
short: E. Benková, E. Witters, W. Van Dongen, J. Kolář, V. Motyka, B. Brzobohatý,
H. Van Onckelen, I. Macháčková, Plant Physiology 121 (1999) 245–251.
date_created: 2018-12-11T12:00:00Z
date_published: 1999-09-01T00:00:00Z
date_updated: 2022-09-07T13:56:12Z
day: '01'
doi: 10.1104/pp.121.1.245
extern: '1'
external_id:
pmid:
- '10482680'
intvolume: ' 121'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59373/
month: '09'
oa: 1
oa_version: Published Version
page: 245 - 251
pmid: 1
publication: Plant Physiology
publication_identifier:
issn:
- 0032-0889
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '3924'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cytokinins in tobacco and wheat chloroplasts. Occurrence and changes due to
light/dark treatment
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 121
year: '1999'
...
---
_id: '3148'
abstract:
- lang: eng
text: Accurate proteolytic processing of neuropeptide and peptide hormone precursors
by members of the kexin/furin family of proteases is key to determining both the
identities and activities of signaling peptides. Here we identify amontillado
(amon), the Drosophila melanogaster homolog of the mammalian neuropeptide processing
protease PC2, and show that in contrast to vertebrate PC2, amontillado expression
undergoes extensive regulation in the nervous system during development. In situ
hybridization reveals that expression of amontillado is restricted to the final
stages of embryogenesis when it is found in anterior sensory structures and in
only 168 cells in the brain and ventral nerve cord. After larvae hatch from their
egg shells, the sensory structures and most cells in the CNS turn off or substantially
reduce amontillado expression, suggesting that amontillado plays a specific role
late in embryogenesis. Larvae lacking the chromosomal region containing amontillado
show no gross anatomical defects and respond to touch. However, such larvae show
a greatly reduced frequency of a hatching behavior of wild- type Drosophila in
which larvae swing their heads, scraping through the eggshell with their mouth
hooks. Ubiquitous expression of amontillado can restore near wild-type levels
of this behavior, whereas expression of amontillado with an alanine substitution
for the catalytic histidine cannot. These results suggest that amontillado expression
is regulated as part of a programmed modulation of neural signaling that controls
hatching behavior by producing specific neuropeptides in particular neurons at
an appropriate developmental time.
acknowledgement: This research was supported by National Institutes of Health Grant
GM39697 to R.S.F. D.S. was supported in part by National Institutes of Health training
Grant 2T32GM07599. We thank M. A. Krasnow and members of his laboratory, particularly
J. Jarecki, for technical guidance, encouragement, and stimulating scientific discussions.
We thank A. Maghbouleh and the Stanford Statistics Department Consulting Service
for help with statistical analysis. We thank G. Beitel, S. Dietrich, K. Guillemin,
D. Micklem, Y. Nakajima, and members of the Fuller and Krasnow laboratories for
comments on this manuscript. We thank M. Palazzolo for the use of theDrosophila
head cDNA library, D. Kiehart for the use of a Drosophila myosin antibody, and D.
Casso, F.-A. Ramirez-Weber, and T. B. Kornberg for use of the D/TM3SbKrGFP flies.
We thank A. R. Kidd, D. Tolla, and M. Bender and D. Casso, F.-A. Ramirez-Weber and
T. B. Kornberg for communication of results before publication
article_processing_charge: No
article_type: original
author:
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Robert
full_name: Fuller, Robert
last_name: Fuller
citation:
ama: Siekhaus DE, Fuller R. A role for amontillado the Drosophila homolog of the
neuropeptide precursor processing protease PC2 in triggering hatching behavior.
Journal of Neuroscience. 1999;19(16):6942-6954. doi:10.1523/jneurosci.19-16-06942.1999
apa: Siekhaus, D. E., & Fuller, R. (1999). A role for amontillado the Drosophila
homolog of the neuropeptide precursor processing protease PC2 in triggering hatching
behavior. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/jneurosci.19-16-06942.1999
chicago: Siekhaus, Daria E, and Robert Fuller. “A Role for Amontillado the Drosophila
Homolog of the Neuropeptide Precursor Processing Protease PC2 in Triggering Hatching
Behavior.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/jneurosci.19-16-06942.1999.
ieee: D. E. Siekhaus and R. Fuller, “A role for amontillado the Drosophila homolog
of the neuropeptide precursor processing protease PC2 in triggering hatching behavior,”
Journal of Neuroscience, vol. 19, no. 16. Society for Neuroscience, pp.
6942–6954, 1999.
ista: Siekhaus DE, Fuller R. 1999. A role for amontillado the Drosophila homolog
of the neuropeptide precursor processing protease PC2 in triggering hatching behavior.
Journal of Neuroscience. 19(16), 6942–6954.
mla: Siekhaus, Daria E., and Robert Fuller. “A Role for Amontillado the Drosophila
Homolog of the Neuropeptide Precursor Processing Protease PC2 in Triggering Hatching
Behavior.” Journal of Neuroscience, vol. 19, no. 16, Society for Neuroscience,
1999, pp. 6942–54, doi:10.1523/jneurosci.19-16-06942.1999.
short: D.E. Siekhaus, R. Fuller, Journal of Neuroscience 19 (1999) 6942–6954.
date_created: 2018-12-11T12:01:40Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:48:41Z
day: '15'
doi: 10.1523/jneurosci.19-16-06942.1999
extern: '1'
external_id:
pmid:
- '10436051 '
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782853/
month: '08'
oa: 1
oa_version: Published Version
page: 6942 - 6954
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '3547'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A role for amontillado the Drosophila homolog of the neuropeptide precursor
processing protease PC2 in triggering hatching behavior
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '11895'
abstract:
- lang: eng
text: In this paper we present an analysis of an AltaVista Search Engine query log
consisting of approximately 1 billion entries for search requests over a period
of six weeks. This represents almost 285 million user sessions, each an attempt
to fill a single information need. We present an analysis of individual queries,
query duplication, and query sessions. We also present results of a correlation
analysis of the log entries, studying the interaction of terms within queries.
Our data supports the conjecture that web users differ significantly from the
user assumed in the standard information retrieval literature. Specifically, we
show that web users type in short queries, mostly look at the first 10 results
only, and seldom modify the query. This suggests that traditional information
retrieval techniques may not work well for answering web search requests. The
correlation analysis showed that the most highly correlated items are constituents
of phrases. This result indicates it may be useful for search engines to consider
search terms as parts of phrases even if the user did not explicitly specify them
as such.
article_processing_charge: No
article_type: original
author:
- first_name: Craig
full_name: Silverstein, Craig
last_name: Silverstein
- first_name: Hannes
full_name: Marais, Hannes
last_name: Marais
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Michael
full_name: Moricz, Michael
last_name: Moricz
citation:
ama: Silverstein C, Marais H, Henzinger MH, Moricz M. Analysis of a very large web
search engine query log. ACM SIGIR Forum. 1999;33(1):6-12. doi:10.1145/331403.331405
apa: Silverstein, C., Marais, H., Henzinger, M. H., & Moricz, M. (1999). Analysis
of a very large web search engine query log. ACM SIGIR Forum. Association
for Computing Machinery. https://doi.org/10.1145/331403.331405
chicago: Silverstein, Craig, Hannes Marais, Monika H Henzinger, and Michael Moricz.
“Analysis of a Very Large Web Search Engine Query Log.” ACM SIGIR Forum.
Association for Computing Machinery, 1999. https://doi.org/10.1145/331403.331405.
ieee: C. Silverstein, H. Marais, M. H. Henzinger, and M. Moricz, “Analysis of a
very large web search engine query log,” ACM SIGIR Forum, vol. 33, no.
1. Association for Computing Machinery, pp. 6–12, 1999.
ista: Silverstein C, Marais H, Henzinger MH, Moricz M. 1999. Analysis of a very
large web search engine query log. ACM SIGIR Forum. 33(1), 6–12.
mla: Silverstein, Craig, et al. “Analysis of a Very Large Web Search Engine Query
Log.” ACM SIGIR Forum, vol. 33, no. 1, Association for Computing Machinery,
1999, pp. 6–12, doi:10.1145/331403.331405.
short: C. Silverstein, H. Marais, M.H. Henzinger, M. Moricz, ACM SIGIR Forum 33
(1999) 6–12.
date_created: 2022-08-17T08:53:02Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2023-02-17T14:46:04Z
day: '01'
doi: 10.1145/331403.331405
extern: '1'
intvolume: ' 33'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1145/331403.331405
month: '01'
oa: 1
oa_version: Published Version
page: 6-12
publication: ACM SIGIR Forum
publication_identifier:
issn:
- 0163-5840
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Analysis of a very large web search engine query log
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '1999'
...
---
_id: '3444'
abstract:
- lang: eng
text: This study examined intermittent, high-frequency (100-200 Hz) oscillatory
patterns in the CA1 region of the hippocampus in the absence of theta activity,
i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal
activity was phase-locked not only to large amplitude (>7 SD from baseline)
oscillatory events, which are present mainly during SPWs, but to smaller amplitude
(<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple"
frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz
("slow") oscillatory patterns. Fast ripple waves reversed just below
the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum
radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated
CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves.
These findings suggest that fast ripples emerge in the CA1 region, whereas slow
(100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred
to the CA1 field.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations
in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience.
1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Fast network oscillations in the hippocampal CA1 region of the behaving rat.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the
Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network
oscillations in the hippocampal CA1 region of the behaving rat,” Journal
of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network
oscillations in the hippocampal CA1 region of the behaving rat. Journal of
Neuroscience. 19(16).
mla: Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal
CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no.
16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999).
date_created: 2018-12-11T12:03:22Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:41:18Z
day: '15'
doi: 10.1523/JNEUROSCI.19-16-j0001.1999
extern: '1'
external_id:
pmid:
- '10436076'
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast network oscillations in the hippocampal CA1 region of the behaving
rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3445'
abstract:
- lang: eng
text: The medial septal region and the hippocampus are connected reciprocally via
GABAergic neurons, but the physiological role of this loop is still not well understood.
In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic
projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta
activity and extracellular units recorded in the medial septum and diagonal band
of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%)
were significantly suppressed during SPWs. Most cells inhibited during SPW (80%)
fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal
layer theta waves. Because both SPW and the negative peak of local theta waves
correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron
classes, the findings indicate that the activity of medial septal neurons can
be negatively (during SPW) or positively (during theta waves) correlated with
the activity of hippocampal interneurons. We hypothesize that the functional coupling
between medial septal neurons and hippocampal interneurons varies in a state-dependent
manner.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and
support and T. F. Freund for his comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Daniel
full_name: Carpi, Daniel
last_name: Carpi
- first_name: Michael
full_name: Recce, Michael
last_name: Recce
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus
and medial septum during sharp waves and theta oscillation in the behaving rat.
Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999
apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999).
Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György
Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves
and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society
for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.
ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions
between hippocampus and medial septum during sharp waves and theta oscillation
in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society
for Neuroscience, pp. 6191–6199, 1999.
ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between
hippocampus and medial septum during sharp waves and theta oscillation in the
behaving rat. Journal of Neuroscience. 19(14), 6191–6199.
mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum
during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience,
vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.
short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience
19 (1999) 6191–6199.
date_created: 2018-12-11T12:03:22Z
date_published: 1999-07-15T00:00:00Z
date_updated: 2022-09-07T13:37:41Z
day: '15'
doi: 10.1523/JNEUROSCI.19-14-06191.1999
extern: '1'
external_id:
pmid:
- '10407055'
intvolume: ' 19'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/
month: '07'
oa: 1
oa_version: Published Version
page: 6191 - 6199
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3518'
abstract:
- lang: eng
text: Information in neuronal networks may be represented by the spatiotemporal
patterns of spikes. Here we examined the temporal coordination of pyramidal cell
spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained
to run in a defined position in space (running wheel) to activate a selected group
of pyramidal cells. A template-matching method and a joint probability map method
were used for sequence search. Repeating spike sequences in excess of chance occurrence
were examined by comparing the number of repeating sequences in the original spike
trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four
different shuffling procedures were used to control for the population dynamics
of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies
were present in both the awake and sleeping animal in excess of what might be
predicted by random variations. Spike sequences observed during wheel running
were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave
sleep. We hypothesize that the endogenously expressed spike sequences during sleep
reflect reactivation of the circuitry modified by previous experience. Reactivation
of acquired sequences may serve to consolidate information.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale
Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and
Matthew Wilson for their suggestions with data analysis and comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression
of recurring spike sequences in the hippocampus. Journal of Neuroscience.
1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999
apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999).
Replay and time compression of recurring spike sequences in the hippocampus. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the
Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.
ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay
and time compression of recurring spike sequences in the hippocampus,” Journal
of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507,
1999.
ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time
compression of recurring spike sequences in the hippocampus. Journal of Neuroscience.
19(21), 9497–9507.
mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences
in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society
for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.
short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of
Neuroscience 19 (1999) 9497–9507.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-11-01T00:00:00Z
date_updated: 2022-09-07T12:48:08Z
day: '01'
doi: 10.1523/JNEUROSCI.19-21-09497.1999
extern: '1'
external_id:
pmid:
- '10531452'
intvolume: ' 19'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/
month: '11'
oa: 1
oa_version: Published Version
page: 9497 - 9507
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2866'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replay and time compression of recurring spike sequences in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3524'
abstract:
- lang: eng
text: We examined whether excitation and inhibition are balanced in hippocampal
cortical networks. Extracellular field and single-unit activity were recorded
by multiple tetrodes and multisite silicon probes to reveal the timing of the
activity of hippocampal CAI pyramidal cells and classes of interneurons during
theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and
dendritic inhibition of pyramidal cells was deduced from the activity of interneurons
in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively.
int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population
discharge of pyramidal cells during the theta cycle, respectively. SPW ripples
were associated with a 2.5-fold net increase of excitation. The discharge frequency
of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent”
cells) during SPW suggesting that not all interneurons are innervated by pyramidal
cells. Int(p) either fired together with (unimodal cells) or both before and after
(bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the
activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum
discharge probability of pyramidal neurons by 1-2 msec. Network state changes,
as reflected by field activity, covaried with changes in the spike train dynamics
of single cells and their interactions. Summed activity of parallel-recorded interneurons,
but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse
was true for the ripple cycles of SPWs. We suggest that network-driven excitability
changes provide temporal windows of opportunity for single pyramidal cells to
suppress, enable, or facilitate selective synaptic inputs.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994,
MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell
A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and
Ken Wise for supplying us with silicon probes.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal
of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving
rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons
in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience,
1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory
coupling of hippocampal pyramidal cells and interneurons in the behaving rat,”
Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp.
274–287, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of
Neuroscience. 19(1), 274–287.
mla: Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal
Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol.
19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999) 274–287.
date_created: 2018-12-11T12:03:47Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T10:00:45Z
day: '01'
doi: 10.1523/JNEUROSCI.19-01-00274.1999
extern: '1'
external_id:
pmid:
- '9870957'
intvolume: ' 19'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/
month: '01'
oa: 1
oa_version: Published Version
page: 274 - 287
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2860'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oscillatory coupling of hippocampal pyramidal cells and interneurons in the
behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3582'
abstract:
- lang: eng
text: We study edge contractions in simplicial complexes and local conditions under
which they preserve the topological type. The conditions are based on a generalized
notion of boundary, which lends itself to defining a nested hierarchy of triangulable
spaces measuring the distance to being a manifold.
acknowledgement: The second author thanks Wolfgang Haken and Min Yan for interesting
discussions and Günter Ziegler for suggesting the knot construction in the triangulation
of the 3-sphere mentioned in Section 7.
article_processing_charge: No
article_type: original
author:
- first_name: Tamal
full_name: Dey, Tamal
last_name: Dey
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Sumanta
full_name: Guha, Sumanta
last_name: Guha
- first_name: Dmitry
full_name: Nekhayev, Dmitry
last_name: Nekhayev
citation:
ama: Dey T, Edelsbrunner H, Guha S, Nekhayev D. Topology preserving edge contraction.
Publications de l’Institut Mathématique. 1999;66:23-45.
apa: Dey, T., Edelsbrunner, H., Guha, S., & Nekhayev, D. (1999). Topology preserving
edge contraction. Publications de l’Institut Mathématique. Mathematical
Institute, Serbian Academy of Sciences and Arts.
chicago: Dey, Tamal, Herbert Edelsbrunner, Sumanta Guha, and Dmitry Nekhayev. “Topology
Preserving Edge Contraction.” Publications de l’Institut Mathématique.
Mathematical Institute, Serbian Academy of Sciences and Arts, 1999.
ieee: T. Dey, H. Edelsbrunner, S. Guha, and D. Nekhayev, “Topology preserving edge
contraction,” Publications de l’Institut Mathématique, vol. 66. Mathematical
Institute, Serbian Academy of Sciences and Arts, pp. 23–45, 1999.
ista: Dey T, Edelsbrunner H, Guha S, Nekhayev D. 1999. Topology preserving edge
contraction. Publications de l’Institut Mathématique. 66, 23–45.
mla: Dey, Tamal, et al. “Topology Preserving Edge Contraction.” Publications
de l’Institut Mathématique, vol. 66, Mathematical Institute, Serbian Academy
of Sciences and Arts, 1999, pp. 23–45.
short: T. Dey, H. Edelsbrunner, S. Guha, D. Nekhayev, Publications de l’Institut
Mathématique 66 (1999) 23–45.
date_created: 2018-12-11T12:04:05Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2023-03-22T13:20:32Z
day: '01'
extern: '1'
intvolume: ' 66'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.emis.de/journals/PIMB/080/3.html
month: '01'
oa: 1
oa_version: None
page: 23 - 45
publication: Publications de l'Institut Mathématique
publication_identifier:
issn:
- 0350-1302
publication_status: published
publisher: Mathematical Institute, Serbian Academy of Sciences and Arts
publist_id: '2803'
quality_controlled: '1'
status: public
title: Topology preserving edge contraction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 66
year: '1999'
...
---
_id: '1955'
abstract:
- lang: eng
text: 'The plastid genomes of several plants contain homologues, termed ndh genes,
of genes encoding subunits of the NADH:ubiquinone oxidoreductase or complex I
of mitochondria and eubacteria. The functional significance of the Ndh proteins
in higher plants is uncertain. We show here that tobacco chloroplasts contain
a protein complex of 550 kDa consisting of at least three of the ndh gene products:
NdhI, NdhJ and NdhK. We have constructed mutant tobacco plants with disrupted
ndhC, ndhK and ndhJ plastid genes, indicating that the Ndh complex is dispensible
for plant growth under optimal growth conditions. Chlorophyll fluorescence analysis
shows that in vivo the Ndh complex catalyses the post-illumination reduction of
the plastoquinone pool and in the light optimizes the induction of photosynthesis
under conditions of water stress. We conclude that the Ndh complex catalyses the
reduction of the plastoquinone pool using stromal reductant and so acts as a respiratory
complex. Overall, our data are compatible with the participation of the Ndh complex
in cyclic electron flow around the photosystem I complex in the light and possibly
in a chloroplast respiratory chain in the dark.'
acknowledgement: We thank Professor Süss (Institute of Plant Genetics and Crop Plant
Research, Gatersleben, Germany) for the gift of the anti-FNR antiserum, Professor
Masahiro Sugiura (Nagoya University, Japan) for the gift of plasmid pTB19 and Professor
Peter Horton (University of Sheffield) for the loan of his ED-800T unit. P.B. is
a recipient of a BBSRC studentship and the work was supported by grants from the
BBSRC, The Royal Society (to P.J.N.) and The National Science Foundation (to P.M.).
article_processing_charge: No
article_type: original
author:
- first_name: Paul
full_name: Burrows, Paul
last_name: Burrows
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Zóra
full_name: Sváb, Zóra
last_name: Sváb
- first_name: Pàl
full_name: Maliga, Pàl
last_name: Maliga
- first_name: Peter
full_name: Nixon, Peter
last_name: Nixon
citation:
ama: Burrows P, Sazanov LA, Sváb Z, Maliga P, Nixon P. Identification of a functional
respiratory complex in chloroplasts through analysis of tobacco mutants containing
disrupted plastid ndh genes. EMBO Journal. 1998;17(4):868-876. doi:10.1093/emboj/17.4.868
apa: Burrows, P., Sazanov, L. A., Sváb, Z., Maliga, P., & Nixon, P. (1998).
Identification of a functional respiratory complex in chloroplasts through analysis
of tobacco mutants containing disrupted plastid ndh genes. EMBO Journal.
Wiley-Blackwell. https://doi.org/10.1093/emboj/17.4.868
chicago: Burrows, Paul, Leonid A Sazanov, Zóra Sváb, Pàl Maliga, and Peter Nixon.
“Identification of a Functional Respiratory Complex in Chloroplasts through Analysis
of Tobacco Mutants Containing Disrupted Plastid Ndh Genes.” EMBO Journal.
Wiley-Blackwell, 1998. https://doi.org/10.1093/emboj/17.4.868.
ieee: P. Burrows, L. A. Sazanov, Z. Sváb, P. Maliga, and P. Nixon, “Identification
of a functional respiratory complex in chloroplasts through analysis of tobacco
mutants containing disrupted plastid ndh genes,” EMBO Journal, vol. 17,
no. 4. Wiley-Blackwell, pp. 868–876, 1998.
ista: Burrows P, Sazanov LA, Sváb Z, Maliga P, Nixon P. 1998. Identification of
a functional respiratory complex in chloroplasts through analysis of tobacco mutants
containing disrupted plastid ndh genes. EMBO Journal. 17(4), 868–876.
mla: Burrows, Paul, et al. “Identification of a Functional Respiratory Complex in
Chloroplasts through Analysis of Tobacco Mutants Containing Disrupted Plastid
Ndh Genes.” EMBO Journal, vol. 17, no. 4, Wiley-Blackwell, 1998, pp. 868–76,
doi:10.1093/emboj/17.4.868.
short: P. Burrows, L.A. Sazanov, Z. Sváb, P. Maliga, P. Nixon, EMBO Journal 17 (1998)
868–876.
date_created: 2018-12-11T11:54:54Z
date_published: 1998-02-04T00:00:00Z
date_updated: 2022-09-01T13:17:49Z
day: '04'
doi: 10.1093/emboj/17.4.868
extern: '1'
external_id:
pmid:
- '9463365'
intvolume: ' 17'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170436/
month: '02'
oa: 1
oa_version: None
page: 868 - 876
pmid: 1
publication: EMBO Journal
publication_identifier:
issn:
- 0261-4189
publication_status: published
publisher: Wiley-Blackwell
publist_id: '5129'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Identification of a functional respiratory complex in chloroplasts through
analysis of tobacco mutants containing disrupted plastid ndh genes
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1998'
...
---
_id: '1956'
abstract:
- lang: eng
text: "\r\nThe plastid genomes of several plants contain ndh genes-homologues of
genes encoding subunits of the proton-pumping NADH:ubiquinone oxidoreductase,
or complex I, involved in respiration in mitochondria and eubacteria. From sequence
similarities with these genes, the ndh gene products have been suggested to form
a large protein complex (Ndh complex); however, the structure and function of
this complex remains to be established. Herein we report the isolation of the
Ndh complex from the chloroplasts of the higher plant Pisum sativum. The purification
procedure involved selective solubilization of the thylakoid membrane with dodecyl
maltoside, followed by two anion-exchange chromatography steps and one size-exclusion
chromatography step. The isolated Ndh complex has an apparent total molecular
mass of approximately 550 kDa and according to SDS/PAGE consists of at least 16
subunits including NdhA, NdhI, NdhJ, NdhK, and NdhH, which were identified by
N-terminal sequencing and immunoblotting. The Ndh complex showed an NADH- and
deamino-NADH-specific dehydrogenase activity, characteristic of complex I, when
either ferricyanide or the quinones menadione and duroquinone were used as electron
acceptors. This study describes the isolation of the chloroplast analogue of the
respiratory complex I and provides direct evidence for the function of the plastid
Ndh complex as an NADH:plastoquinone oxidoreductase. Our results are compatible
with a dual role for the Ndh complex in the chloro-respiratory and cyclic photophosphorylation
pathways."
acknowledgement: We gratefully acknowledge Dr. A.Carne (Institute of Cancer Research,
London, U.K.) for help with N-terminal sequencing. We thank Prof. C. J. Leaver (University
of Oxford, U.K.), Prof. K.-H. Süss (Institute of Plant Genetics and Crop Plant Research,
Gatersleben, Germany), and Prof. L. J. Rogers (University of Aberystwyth, U.K.)
for gifts of antiserum against maize mitochondrial cytochrome oxidase subunit 1
and cytochrome bc1 complex, spinach FNR, and spinach ferredoxin, respectively. This
work was supported by grants from The Royal Society and the Biotechnology and Biological
Sciences Research Council.
article_processing_charge: No
article_type: original
author:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
- first_name: Paul
full_name: Burrows, Paul
last_name: Burrows
- first_name: Peter
full_name: Nixon, Peter
last_name: Nixon
citation:
ama: 'Sazanov LA, Burrows P, Nixon P. The plastid ndh genes code for an NADH-specific
dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes.
PNAS. 1998;95(3):1319-1324. doi:10.1073/pnas.95.3.1319'
apa: 'Sazanov, L. A., Burrows, P., & Nixon, P. (1998). The plastid ndh genes
code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from
pea thylakoid membranes. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.95.3.1319'
chicago: 'Sazanov, Leonid A, Paul Burrows, and Peter Nixon. “The Plastid Ndh Genes
Code for an NADH-Specific Dehydrogenase: Isolation of a Complex I Analogue from
Pea Thylakoid Membranes.” PNAS. National Academy of Sciences, 1998. https://doi.org/10.1073/pnas.95.3.1319.'
ieee: 'L. A. Sazanov, P. Burrows, and P. Nixon, “The plastid ndh genes code for
an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid
membranes,” PNAS, vol. 95, no. 3. National Academy of Sciences, pp. 1319–1324,
1998.'
ista: 'Sazanov LA, Burrows P, Nixon P. 1998. The plastid ndh genes code for an NADH-specific
dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes.
PNAS. 95(3), 1319–1324.'
mla: 'Sazanov, Leonid A., et al. “The Plastid Ndh Genes Code for an NADH-Specific
Dehydrogenase: Isolation of a Complex I Analogue from Pea Thylakoid Membranes.”
PNAS, vol. 95, no. 3, National Academy of Sciences, 1998, pp. 1319–24,
doi:10.1073/pnas.95.3.1319.'
short: L.A. Sazanov, P. Burrows, P. Nixon, PNAS 95 (1998) 1319–1324.
date_created: 2018-12-11T11:54:54Z
date_published: 1998-02-03T00:00:00Z
date_updated: 2022-09-01T13:47:05Z
day: '03'
doi: 10.1073/pnas.95.3.1319
extern: '1'
external_id:
pmid:
- '9448329 '
intvolume: ' 95'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://europepmc.org/article/pmc/18756
month: '02'
oa: 1
oa_version: None
page: 1319 - 1324
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '5130'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of
a complex I analogue from pea thylakoid membranes'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 95
year: '1998'
...
---
_id: '1449'
abstract:
- lang: eng
text: In this paper we consider a canonical compactification of M, the moduli space
of stable Higgs bundles with fixed determinant of odd degree over a Riemann surface
Σ, producing a projective variety M̄ = M ∪ Z. We give a detailed study of the
spaces M̄, Z and M. In doing so we reprove some assertions of Laumon and Thaddeus
on the nilpotent cone.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tamas
full_name: Hausel, Tamas
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
citation:
ama: Hausel T. Compactification of moduli of Higgs bundles. Journal fur die Reine
und Angewandte Mathematik. 1998;1998(503):169-192. doi:10.1515/crll.1998.096
apa: Hausel, T. (1998). Compactification of moduli of Higgs bundles. Journal
Fur Die Reine Und Angewandte Mathematik. Walter de Gruyter. https://doi.org/10.1515/crll.1998.096
chicago: Hausel, Tamás. “Compactification of Moduli of Higgs Bundles.” Journal
Fur Die Reine Und Angewandte Mathematik. Walter de Gruyter, 1998. https://doi.org/10.1515/crll.1998.096.
ieee: T. Hausel, “Compactification of moduli of Higgs bundles,” Journal fur die
Reine und Angewandte Mathematik, vol. 1998, no. 503. Walter de Gruyter, pp.
169–192, 1998.
ista: Hausel T. 1998. Compactification of moduli of Higgs bundles. Journal fur die
Reine und Angewandte Mathematik. 1998(503), 169–192.
mla: Hausel, Tamás. “Compactification of Moduli of Higgs Bundles.” Journal Fur
Die Reine Und Angewandte Mathematik, vol. 1998, no. 503, Walter de Gruyter,
1998, pp. 169–92, doi:10.1515/crll.1998.096.
short: T. Hausel, Journal Fur Die Reine Und Angewandte Mathematik 1998 (1998) 169–192.
date_created: 2018-12-11T11:52:05Z
date_published: 1998-10-01T00:00:00Z
date_updated: 2022-09-01T13:51:07Z
day: '01'
doi: 10.1515/crll.1998.096
extern: '1'
external_id:
arxiv:
- math/9804083
intvolume: ' 1998'
issue: '503'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/9804083
month: '10'
oa: 1
oa_version: Preprint
page: 169 - 192
publication: Journal fur die Reine und Angewandte Mathematik
publication_identifier:
issn:
- 1435-5345
publication_status: published
publisher: Walter de Gruyter
publist_id: '5746'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Compactification of moduli of Higgs bundles
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 1998
year: '1998'
...
---
_id: '1450'
abstract:
- lang: eng
text: In this paper we consider the topological side of a problem which is the analogue
of Sen's S-duality testing conjecture for Hitchin's moduli space M of rank 2 stable
Higgs bundles of fixed determinant of odd degree over a Riemann surface ∑. We
prove that all intersection numbers in the compactly supported cohomology of M
vanish, i.e. "there are no topological L2 harmonic forms on M". This
result generalizes the well known vanishing of the Euler characteristic of the
moduli space of rank 2 stable bundles N of fixed determinant of odd degree over
∑. Our proof shows that the vanishing of all intersection numbers of H* cpt(M)
is given by relations analogous to the Mumford relations in the cohomology ring
of N.
acknowledgement: "First of all I would like to thank my supervisor Nigel Hitchin for
suggesting Problem 1, and for his help and \r\n encouragement. I am grateful to
Michael Thaddeus for his inspiring paper [Thai], enlightening communications and
his constant interest in my work. I am also indebted to Manfred Lehn for the idea
of the proof of Theorem 6.2. I have found\r\nconversations with Michael Atiyah,
Frances Kirwan and Graeme Segal very stimulating. I thank the Mathematical Institute
and St. Catherine's College, Oxford for their hospitality during the preparation
of this work. Finally I thank Trinity College, Cambridge for financial support."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tamas
full_name: Hausel, Tamas
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
citation:
ama: Hausel T. Vanishing of intersection numbers on the moduli space of Higgs bundles.
Advances in Theoretical and Mathematical Physics. 1998;2(5):1011-1040.
doi:10.4310/ATMP.1998.v2.n5.a3
apa: Hausel, T. (1998). Vanishing of intersection numbers on the moduli space of
Higgs bundles. Advances in Theoretical and Mathematical Physics. International
Press. https://doi.org/10.4310/ATMP.1998.v2.n5.a3
chicago: Hausel, Tamás. “Vanishing of Intersection Numbers on the Moduli Space of
Higgs Bundles.” Advances in Theoretical and Mathematical Physics. International
Press, 1998. https://doi.org/10.4310/ATMP.1998.v2.n5.a3.
ieee: T. Hausel, “Vanishing of intersection numbers on the moduli space of Higgs
bundles,” Advances in Theoretical and Mathematical Physics, vol. 2, no.
5. International Press, pp. 1011–1040, 1998.
ista: Hausel T. 1998. Vanishing of intersection numbers on the moduli space of Higgs
bundles. Advances in Theoretical and Mathematical Physics. 2(5), 1011–1040.
mla: Hausel, Tamás. “Vanishing of Intersection Numbers on the Moduli Space of Higgs
Bundles.” Advances in Theoretical and Mathematical Physics, vol. 2, no.
5, International Press, 1998, pp. 1011–40, doi:10.4310/ATMP.1998.v2.n5.a3.
short: T. Hausel, Advances in Theoretical and Mathematical Physics 2 (1998) 1011–1040.
date_created: 2018-12-11T11:52:06Z
date_published: 1998-09-01T00:00:00Z
date_updated: 2022-09-01T14:09:49Z
day: '01'
doi: 10.4310/ATMP.1998.v2.n5.a3
extern: '1'
external_id:
arxiv:
- math/9805071
intvolume: ' 2'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/9805071
month: '09'
oa: 1
oa_version: Preprint
page: 1011 - 1040
publication: Advances in Theoretical and Mathematical Physics
publication_identifier:
issn:
- 1095-0761
publication_status: published
publisher: International Press
publist_id: '5747'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Vanishing of intersection numbers on the moduli space of Higgs bundles
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2
year: '1998'
...
---
_id: '3488'
abstract:
- lang: eng
text: We have examined gating and pharmacological characteristics of somatic K+
channels in fast-spiking interneurons and regularly spiking principal neurons
of hippocampal slices. In nucleated patches isolated from basket cells of the
dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive
to tetraethylammonium (TEA) and 4-aminopyridine (4- AP) (half-maximal inhibitory
concentrations <0.1 mM) predominated, contributing an average of 58% to the
total K+ current in these cells. By contrast, in pyramidal neurons of the CA1
region a rapidly inactivating A- type K+ current component that was TEA-resistant
prevailed, contributing 61% to the total K+ current. Both types of neurons also
showed small amounts of the K+ current component mainly found in the other type
of neuron and, in addition, a slow delayed rectifier K+ current component with
intermediate properties (sow inactivation, intermediate sensitivity to TEA). Single-cell
RT-PCR analysis of mRNA revealed that Kv3 (Kv3.1, Kv3.2) subunit transcripts were
expressed in almost all (89%) of the interneurons but only in 17% of the pyramidal
neurons. In contrast, Kv4 (Kv4.2, Kv4.3) subunit mRNAs were present in 87% of
pyramidal neurons but only in 55% of interneurons. Selective block of fast delayed
rectifier K+ channels, presumably assembled from Kv3 subunits, by 4-AP reduced
substantially the action potential frequency in interneurons. These results indicate
that the differential expression of Kv3 and Kv4 subunits shapes the action potential
phenotypes of principal neurons and interneurons in the cortex.
acknowledgement: Supported by German Israeli Foundation Grant I 0352–073.01/94 to
P.J. and Deutsche Forschungsgemeinschaft Grant Mo 432/3–1 to H.M. We thank Drs.
L. Y. Jan, D. McKinnon, O. Pongs, L. Salkoff, S. H. Snyder, and J. S. Trimmer for
providing plasmids, Dr. D. J. Surmeier for sharing unpublished data, and Drs. J.
Bischofberger and J. R. P. Geiger for critically reading this manuscript. M.M. and
J.H.S. contributed equally to this work.
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Jobst
full_name: Schultz, Jobst
last_name: Schultz
- first_name: Heimo
full_name: Ehmke, Heimo
last_name: Ehmke
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Martina M, Schultz J, Ehmke H, Monyer H, Jonas PM. Functional and molecular
differences between voltage-gated K+ channels of fast-spiking interneurons and
pyramidal neurons of rat hippocampus. Journal of Neuroscience. 1998;18(20):8111-8125.
doi:10.1523/JNEUROSCI.18-20-08111.1998
apa: Martina, M., Schultz, J., Ehmke, H., Monyer, H., & Jonas, P. M. (1998).
Functional and molecular differences between voltage-gated K+ channels of fast-spiking
interneurons and pyramidal neurons of rat hippocampus. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998
chicago: Martina, Marco, Jobst Schultz, Heimo Ehmke, Hannah Monyer, and Peter M
Jonas. “Functional and Molecular Differences between Voltage-Gated K+ Channels
of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1998. https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998.
ieee: M. Martina, J. Schultz, H. Ehmke, H. Monyer, and P. M. Jonas, “Functional
and molecular differences between voltage-gated K+ channels of fast-spiking interneurons
and pyramidal neurons of rat hippocampus,” Journal of Neuroscience, vol.
18, no. 20. Society for Neuroscience, pp. 8111–8125, 1998.
ista: Martina M, Schultz J, Ehmke H, Monyer H, Jonas PM. 1998. Functional and molecular
differences between voltage-gated K+ channels of fast-spiking interneurons and
pyramidal neurons of rat hippocampus. Journal of Neuroscience. 18(20), 8111–8125.
mla: Martina, Marco, et al. “Functional and Molecular Differences between Voltage-Gated
K+ Channels of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus.”
Journal of Neuroscience, vol. 18, no. 20, Society for Neuroscience, 1998,
pp. 8111–25, doi:10.1523/JNEUROSCI.18-20-08111.1998.
short: M. Martina, J. Schultz, H. Ehmke, H. Monyer, P.M. Jonas, Journal of Neuroscience
18 (1998) 8111–8125.
date_created: 2018-12-11T12:03:35Z
date_published: 1998-10-15T00:00:00Z
date_updated: 2022-08-29T14:20:39Z
day: '15'
doi: 10.1523/JNEUROSCI.18-20-08111.1998
extern: '1'
external_id:
pmid:
- '9763458'
intvolume: ' 18'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792860/
month: '10'
oa: 1
oa_version: None
page: 8111 - 8125
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2899'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional and molecular differences between voltage-gated K+ channels of fast-spiking
interneurons and pyramidal neurons of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '1998'
...
---
_id: '3506'
abstract:
- lang: eng
text: A method of geometric morphing between a first object having a first shape
and a second object having a second shape. The method includes the steps of generating
a first Delaunay complex corresponding to the first shape and a second Delaunay
complex corresponding to the second shape and generating a plurality of intermediary
Delaunay complexes defined by a continuous family of mixed shapes corresponding
to a mixing of the first shape and the second shape. The method further includes
the steps of constructing a first skin corresponding to the first Delaunay complex
and a second skin corresponding to the second Delaunay complex and constructing
a plurality of intermediary skins corresponding to the plurality of intermediary
Delaunay complexes. The first skin, second skin and plurality of intermediary
skins may be visually displayed on an output device.
applicant:
- Raindrop Geomagic, Inc.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
citation:
ama: Edelsbrunner H, Fu P. Apparatus and method for geometric morphing. 1998.
apa: Edelsbrunner, H., & Fu, P. (1998). Apparatus and method for geometric morphing.
chicago: Edelsbrunner, Herbert, and Ping Fu. “Apparatus and Method for Geometric
Morphing,” 1998.
ieee: H. Edelsbrunner and P. Fu, “Apparatus and method for geometric morphing.”
1998.
ista: Edelsbrunner H, Fu P. 1998. Apparatus and method for geometric morphing.
mla: Edelsbrunner, Herbert, and Ping Fu. Apparatus and Method for Geometric Morphing.
1998.
short: H. Edelsbrunner, P. Fu, (1998).
date_created: 2018-12-11T12:03:41Z
date_published: 1998-12-15T00:00:00Z
date_updated: 2022-01-05T15:16:35Z
day: '15'
extern: '1'
ipc: G06T13/20 ; G06T2210/44
ipn: US5850229A
main_file_link:
- open_access: '1'
url: https://patents.google.com/patent/US5850229A
month: '12'
oa: 1
oa_version: Published Version
publication_date: 1998-12-15
publist_id: '2881'
status: public
title: Apparatus and method for geometric morphing
type: patent
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '1998'
...
---
_id: '3628'
abstract:
- lang: eng
text: 'Determining the way in which deleterious mutations interact in their effects
on fitness is crucial to numerous areas in population genetics and evolutionary
biology. For example, if each additional mutation leads to a greater decrease
in log fitness than the last (synergistic epistasis), then the evolution of sex
and recombination may be favored to facilitate the elimination of deleterious
mutations. However, there is a severe shortage of relevant data. Three relatively
simple experimental methods to test for epistasis between deleterious mutations
in haploid species have recently been proposed. These methods involve crossing
individuals and examining the mean and/or skew in log fitness of the offspring
and parents. The main aim of this paper is to formalize these methods, and determine
the most effective way in which tests for epistasis could be carried out. We show
that only one of these methods is likely to give useful results: crossing individuals
that have very different numbers of deleterious mutations, and comparing the mean
log fitness of the parents with that of their offspring. We also reconsider experimental
data collected on Chlamydomonas moewussi using two of the three methods. Finally,
we suggest how the test could be applied to diploid species.'
acknowledgement: We thank BRIAN CHARLESWORTH, ANDREW CLARK, LAURENCE HURST, PETER KEIGHTLEY,
ALEXEY KONDRASHOV, CURT LIVELY, MARGARET MACKINNON, KATRINA LYTHGOE, SALLY OTTO,
ANDREW READ and ARJAN DE VISSER for useful discussion and comments on the manuscript.
This work was supported by the Biotechnology and Biological Sciences Research Council.
article_processing_charge: No
article_type: original
author:
- first_name: Stuart
full_name: West, Stuart
last_name: West
- first_name: Andrew
full_name: Peters, Andrew
last_name: Peters
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: West S, Peters A, Barton NH. Testing for epistasis between deleterious mutations.
Genetics. 1998;149(1):435-444. doi:10.1093/genetics/149.1.435
apa: West, S., Peters, A., & Barton, N. H. (1998). Testing for epistasis between
deleterious mutations. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/149.1.435
chicago: West, Stuart, Andrew Peters, and Nicholas H Barton. “Testing for Epistasis
between Deleterious Mutations.” Genetics. Genetics Society of America,
1998. https://doi.org/10.1093/genetics/149.1.435.
ieee: S. West, A. Peters, and N. H. Barton, “Testing for epistasis between deleterious
mutations,” Genetics, vol. 149, no. 1. Genetics Society of America, pp.
435–444, 1998.
ista: West S, Peters A, Barton NH. 1998. Testing for epistasis between deleterious
mutations. Genetics. 149(1), 435–444.
mla: West, Stuart, et al. “Testing for Epistasis between Deleterious Mutations.”
Genetics, vol. 149, no. 1, Genetics Society of America, 1998, pp. 435–44,
doi:10.1093/genetics/149.1.435.
short: S. West, A. Peters, N.H. Barton, Genetics 149 (1998) 435–444.
date_created: 2018-12-11T12:04:19Z
date_published: 1998-05-01T00:00:00Z
date_updated: 2022-08-29T08:53:09Z
day: '01'
doi: 10.1093/genetics/149.1.435
extern: '1'
external_id:
pmid:
- '9584115'
intvolume: ' 149'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://academic.oup.com/genetics/article/149/1/435/6034229
month: '05'
oa: 1
oa_version: None
page: 435 - 444
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2755'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Testing for epistasis between deleterious mutations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 149
year: '1998'
...
---
_id: '4013'
abstract:
- lang: eng
text: The shape of a protein is important for its functions, This includes the location
and size of identifiable regions in its complement space. We formally define pockets
as regions in the complement with limited accessibility from the outside. Pockets
can be efficiently constructed by an algorithm based on alpha complexes. The algorithm
is implemented and applied to proteins with known three-dimensional conformations.
1998 Published by Elsevier Science B.V. All rights reserved.
acknowledgement: 'The authors thank Ping Fu and Ernst Miicke for their contributions
to the alpha shapes software in which the pockets software is embedded. '
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michael
full_name: Facello, Michael
last_name: Facello
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
citation:
ama: Edelsbrunner H, Facello M, Liang J. On the definition and the construction
of pockets in macromolecules. Discrete Applied Mathematics. 1998;88(1-3):83-102.
doi:10.1016/S0166-218X(98)00067-5
apa: Edelsbrunner, H., Facello, M., & Liang, J. (1998). On the definition and
the construction of pockets in macromolecules. Discrete Applied Mathematics.
Elsevier. https://doi.org/10.1016/S0166-218X(98)00067-5
chicago: Edelsbrunner, Herbert, Michael Facello, and Jie Liang. “On the Definition
and the Construction of Pockets in Macromolecules.” Discrete Applied Mathematics.
Elsevier, 1998. https://doi.org/10.1016/S0166-218X(98)00067-5.
ieee: H. Edelsbrunner, M. Facello, and J. Liang, “On the definition and the construction
of pockets in macromolecules,” Discrete Applied Mathematics, vol. 88, no.
1–3. Elsevier, pp. 83–102, 1998.
ista: Edelsbrunner H, Facello M, Liang J. 1998. On the definition and the construction
of pockets in macromolecules. Discrete Applied Mathematics. 88(1–3), 83–102.
mla: Edelsbrunner, Herbert, et al. “On the Definition and the Construction of Pockets
in Macromolecules.” Discrete Applied Mathematics, vol. 88, no. 1–3, Elsevier,
1998, pp. 83–102, doi:10.1016/S0166-218X(98)00067-5.
short: H. Edelsbrunner, M. Facello, J. Liang, Discrete Applied Mathematics 88 (1998)
83–102.
date_created: 2018-12-11T12:06:26Z
date_published: 1998-11-09T00:00:00Z
date_updated: 2022-08-25T15:06:30Z
day: '09'
doi: 10.1016/S0166-218X(98)00067-5
extern: '1'
external_id:
pmid:
- '9390238'
intvolume: ' 88'
issue: 1-3
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0166218X98000675?via%3Dihub
month: '11'
oa: 1
oa_version: Published Version
page: 83 - 102
pmid: 1
publication: Discrete Applied Mathematics
publication_identifier:
issn:
- 0166-218X
publication_status: published
publisher: Elsevier
publist_id: '2114'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the definition and the construction of pockets in macromolecules
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 88
year: '1998'
...
---
_id: '4017'
abstract:
- lang: eng
text: Identification and size characterization of surface pockets and occluded cavities
are initial steps in protein structure-based ligand design. A new program, CAST,
for automatically locating and measuring protein pockets and cavities, is based
on precise computational geometry methods, including alpha shape and discrete
flow theory. CAST identifies and measures pockets and pocket mouth openings, as
well as cavities. The program specifies the atoms lining pockets, pocket openings.
and buried cavities; the volume and area of pockets and cavities; and the area
and circumference of mouth openings. CAST analysis of over 100 proteins has been
carried out; proteins examined include a set of 51 monomeric enzyme-ligand structures,
several elastase-inhibitor complexes, the FK506 binding protein, 30 HIV-1 protease-inhibitor
complexes, and a number of small and large protein inhibitors, Medium-sized globular
proteins typically have 10-20 pockets/cavities. Most often, binding sites are
pockets with 1-2 mouth openings; much less frequently they are cavities. Ligand
binding pockets vary widely in size, most within the range 10(2)-10(3) Angstrom(3).
Statistical analysis reveals that the number of pockets and cavities is correlated
with protein size, but there is no correlation between the size of the protein
and the size of binding sites. Most frequently, the largest pocket/cavity is thp
active site, but there are a number of instructive exceptions. Ligand volume and
binding site volume are somewhat correlated when binding site volume is less than
or equal to 700 Angstrom(3), but the ligand seldom occupies the entire site. Auxiliary
pockets near the active site have been suggested as additional binding surface
for designed ligands (Mattos C ct al., 1993, Nat Struct Biol 1:55-58). Analysis
of elastase-inhibitor complexes suggests that CAST can identify ancillary pockets,
suitable for recruitment in ligand design strategies. Analysis of the FK506 binding
protein, and of compounds developed in SAR by NMR (Shuker SE et al.. 1996, Science
274:1531-1534), indicates that CAST pocket computation may provide a priori identification
of target proteins for Linked-fragment design. CAST analysis of 30 HIV-1 protease-inhibitor
complexes shows that the flexible active site pocket can vary over a range of
853-1,566 Angstrom(3), and that there are two pockets near or adjoining the active
site that may be recruited for ligand design.
article_processing_charge: No
article_type: original
author:
- first_name: Jie
full_name: Liang, Jie
last_name: Liang
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Clare
full_name: Woodward, Clare
last_name: Woodward
citation:
ama: 'Liang J, Edelsbrunner H, Woodward C. Anatomy of protein pockets and cavities:
Measurement of binding site geometry and implications for ligand design. Protein
Science. 1998;7(9):1884-1897. doi:10.1002/pro.5560070905'
apa: 'Liang, J., Edelsbrunner, H., & Woodward, C. (1998). Anatomy of protein
pockets and cavities: Measurement of binding site geometry and implications for
ligand design. Protein Science. Wiley-Blackwell. https://doi.org/10.1002/pro.5560070905'
chicago: 'Liang, Jie, Herbert Edelsbrunner, and Clare Woodward. “Anatomy of Protein
Pockets and Cavities: Measurement of Binding Site Geometry and Implications for
Ligand Design.” Protein Science. Wiley-Blackwell, 1998. https://doi.org/10.1002/pro.5560070905.'
ieee: 'J. Liang, H. Edelsbrunner, and C. Woodward, “Anatomy of protein pockets and
cavities: Measurement of binding site geometry and implications for ligand design,”
Protein Science, vol. 7, no. 9. Wiley-Blackwell, pp. 1884–1897, 1998.'
ista: 'Liang J, Edelsbrunner H, Woodward C. 1998. Anatomy of protein pockets and
cavities: Measurement of binding site geometry and implications for ligand design.
Protein Science. 7(9), 1884–1897.'
mla: 'Liang, Jie, et al. “Anatomy of Protein Pockets and Cavities: Measurement of
Binding Site Geometry and Implications for Ligand Design.” Protein Science,
vol. 7, no. 9, Wiley-Blackwell, 1998, pp. 1884–97, doi:10.1002/pro.5560070905.'
short: J. Liang, H. Edelsbrunner, C. Woodward, Protein Science 7 (1998) 1884–1897.
date_created: 2018-12-11T12:06:27Z
date_published: 1998-09-01T00:00:00Z
date_updated: 2022-08-25T12:49:41Z
day: '01'
doi: 10.1002/pro.5560070905
extern: '1'
external_id:
pmid:
- '9761470 '
intvolume: ' 7'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2144175/
month: '09'
oa: 1
oa_version: Published Version
page: 1884 - 1897
pmid: 1
publication: Protein Science
publication_identifier:
issn:
- 0961-8368
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2111'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Anatomy of protein pockets and cavities: Measurement of binding site geometry
and implications for ligand design'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '1998'
...
---
_id: '4492'
abstract:
- lang: eng
text: Hybrid automata model systems with both digital and analog components, such
as embedded control programs. Many verification tasks for such programs can be
expressed as reachability problems for hybrid automata. By improving on previous
decidability and undecidability results, we identify a boundary between decidability
and undecidability for the reachability problem of hybrid automata. On the positive
side, we give an (optimal) PSPACE reachability algorithm for the case of initialized
rectangular automata, where all analog variables follow independent trajectories
within piecewise-linear envelopes and are reinitialized whenever the envelope
changes. Our algorithm is based on the construction of a timed automaton that
contains all reachability information about a given initialized rectangular automaton.
The translation has practical significance for verification, because it guarantees
the termination of symbolic procedures for the reachability analysis of initialized
rectangular automata. The translation also preserves theω-languages of initialized
rectangular automata with bounded nondeterminism. On the negative side, we show
that several slight generalizations of initialized rectangular automata lead to
an undecidable reachability problem. In particular, we prove that the reachability
problem is undecidable for timed automata augmented with a single stopwatch.
acknowledgement: This research was supported in part by the Office of Naval Research
Young Investigator Award N00014-95-1-0520, by the National Science Foundation CAREER
award CCR-9501708, by the National Science Foundation Grant CCR-9504469, by the
Air Force Office of Scientific Research Contract F49620-93-1-0056, by the Army Research
Office MURI Grant DAAH-04-96-1-0341, by the Army Research Office Contract DAAH-04-94-G-0026,
by the Defense Advanced Research Projects Agency Grant NAG2-892, and by the California
PATH program.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Peter
full_name: Kopke, Peter
last_name: Kopke
- first_name: Anuj
full_name: Puri, Anuj
last_name: Puri
- first_name: P.
full_name: Varaiya, P.
last_name: Varaiya
citation:
ama: Henzinger TA, Kopke P, Puri A, Varaiya P. What’s decidable about hybrid automata?
Journal of Computer and System Sciences. 1998;57(1):94-124. doi:10.1006/jcss.1998.1581
apa: Henzinger, T. A., Kopke, P., Puri, A., & Varaiya, P. (1998). What’s decidable
about hybrid automata? Journal of Computer and System Sciences. Elsevier.
https://doi.org/10.1006/jcss.1998.1581
chicago: Henzinger, Thomas A, Peter Kopke, Anuj Puri, and P. Varaiya. “What’s Decidable
about Hybrid Automata?” Journal of Computer and System Sciences. Elsevier,
1998. https://doi.org/10.1006/jcss.1998.1581.
ieee: T. A. Henzinger, P. Kopke, A. Puri, and P. Varaiya, “What’s decidable about
hybrid automata?,” Journal of Computer and System Sciences, vol. 57, no.
1. Elsevier, pp. 94–124, 1998.
ista: Henzinger TA, Kopke P, Puri A, Varaiya P. 1998. What’s decidable about hybrid
automata? Journal of Computer and System Sciences. 57(1), 94–124.
mla: Henzinger, Thomas A., et al. “What’s Decidable about Hybrid Automata?” Journal
of Computer and System Sciences, vol. 57, no. 1, Elsevier, 1998, pp. 94–124,
doi:10.1006/jcss.1998.1581.
short: T.A. Henzinger, P. Kopke, A. Puri, P. Varaiya, Journal of Computer and System
Sciences 57 (1998) 94–124.
date_created: 2018-12-11T12:09:08Z
date_published: 1998-01-01T00:00:00Z
date_updated: 2022-08-23T14:29:15Z
day: '01'
doi: 10.1006/jcss.1998.1581
extern: '1'
intvolume: ' 57'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0022000098915811
month: '01'
oa: 1
oa_version: Published Version
page: 94 - 124
publication: Journal of Computer and System Sciences
publication_identifier:
isbn:
- 0022-0000
publication_status: published
publisher: Elsevier
publist_id: '237'
quality_controlled: '1'
status: public
title: What's decidable about hybrid automata?
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 57
year: '1998'
...
---
_id: '2582'
abstract:
- lang: eng
text: 'Neurotransmission in the hippocampus is modulated variously through presynaptic
metabotropic glutamate receptors (mGluRs). To establish the precise localization
of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies
for eight mGluRs (mGluR1-mGluR8) for immunohistochemistry combined with lesioning
of the three major hippocampal pathways: the perforant path, mossy fiber, and
Schaffer collateral. Immunoreactivity for group II (mGluR2) and group III (mGluR4a,
mGluR7a, mGluR7b, and mGluR8) mGluRs was predominantly localized to presynaptic
elements, whereas that for group I mGluRs (mGluR1 and mGluR5) was localized to
postsynaptic elements. The medial perforant path was strongly immunoreactive for
mGluR2 and mGluR7a throughout the hippocampus, and the lateral perforant path
was prominently immunoreactive for mGluR8 in the dentate gyrus and CA3 area. The
messy fiber was labeled for mGluR2, mGluR7a, and mGluR7b, whereas the Schaffer
collateral was labeled only for mGluR7a. Electron microscopy further revealed
the spatial segregation of group II and group III mGluRs within presynaptic elements.
Immunolabeling for the group III receptors was predominantly observed in presynaptic
active zones of asymmetrical and symmetrical synapses, whereas that for the group
II receptor (mGluR2) was found in preterminal rather than terminal portions of
axons. Target cell-specific segregation of receptors, first reported for mGluR7a
(Shigemoto et al., 1996), was also apparent for the other group III mGluRs, suggesting
that transmitter release is differentially regulated by 2-amino- 4-phosphonobutyrate-sensitive
mGluRs in individual synapses on single axons according to the identity of postsynaptic
neurons.'
acknowledgement: This work was supported by research grants from the Inamori Foundation
and the Ministry of Education, Science, Sports and Culture of Japan. We thank Peter
Somogyi for helpful discussion, David Roberts for technical assistance, and Akira
Uesugi for photographic assistance. We are grateful to Atsu Aiba, David Hampson,
John Roder, and Herman van der Putten for providing us with mGluR1-, mGluR4-, mGluR5-,
and mGluR7-deficient mice, respectively, and to Corrado Corti and Francesco Ferraguti
for sharing rat mGluR8 cDNA and unpublished results.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Eiki
full_name: Wada, Eiki
last_name: Wada
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Kinoshita A, Wada E, et al. Differential presynaptic localization
of metabotropic glutamate receptor subtypes in the rat hippocampus. Journal
of Neuroscience. 1997;17(19):7503-7522. doi:10.1523/JNEUROSCI.17-19-07503.1997
apa: Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M.,
… Mizuno, N. (1997). Differential presynaptic localization of metabotropic glutamate
receptor subtypes in the rat hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997
chicago: Shigemoto, Ryuichi, Ayae Kinoshita, Eiki Wada, Sakashi Nomura, Hitoshi
Ohishi, Masahiko Takada, Peter Flor, et al. “Differential Presynaptic Localization
of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997.
ieee: R. Shigemoto et al., “Differential presynaptic localization of metabotropic
glutamate receptor subtypes in the rat hippocampus,” Journal of Neuroscience,
vol. 17, no. 19. Society for Neuroscience, pp. 7503–7522, 1997.
ista: Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor P, Neki
A, Abe T, Nakanishi S, Mizuno N. 1997. Differential presynaptic localization of
metabotropic glutamate receptor subtypes in the rat hippocampus. Journal of Neuroscience.
17(19), 7503–7522.
mla: Shigemoto, Ryuichi, et al. “Differential Presynaptic Localization of Metabotropic
Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal of Neuroscience,
vol. 17, no. 19, Society for Neuroscience, 1997, pp. 7503–22, doi:10.1523/JNEUROSCI.17-19-07503.1997.
short: R. Shigemoto, A. Kinoshita, E. Wada, S. Nomura, H. Ohishi, M. Takada, P.
Flor, A. Neki, T. Abe, S. Nakanishi, N. Mizuno, Journal of Neuroscience 17 (1997)
7503–7522.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-22T11:32:01Z
day: '01'
doi: 10.1523/JNEUROSCI.17-19-07503.1997
extern: '1'
external_id:
pmid:
- '9295396'
intvolume: ' 17'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573434/
month: '10'
oa: 1
oa_version: Published Version
page: 7503 - 7522
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4317'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential presynaptic localization of metabotropic glutamate receptor subtypes
in the rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '11767'
abstract:
- lang: eng
text: We give a linear-time algorithm for single-source shortest paths in planar
graphs with nonnegative edge-lengths. Our algorithm also yields a linear-time
algorithm for maximum flow in a planar graph with the source and sink on the same
face. For the case where negative edge-lengths are allowed, we give an algorithm
requiringO(n4/3 log(nL)) time, whereLis the absolute value of the most negative
length. This algorithm can be used to obtain similar bounds for computing a feasible
flow in a planar network, for finding a perfect matching in a planar bipartite
graph, and for finding a maximum flow in a planar graph when the source and sink
are not on the same face. We also give parallel and dynamic versions of these
algorithms.
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Philip
full_name: Klein, Philip
last_name: Klein
- first_name: Satish
full_name: Rao, Satish
last_name: Rao
- first_name: Sairam
full_name: Subramanian, Sairam
last_name: Subramanian
citation:
ama: Henzinger MH, Klein P, Rao S, Subramanian S. Faster shortest-path algorithms
for planar graphs. Journal of Computer and System Sciences. 1997;55(1):3-23.
doi:10.1006/jcss.1997.1493
apa: Henzinger, M. H., Klein, P., Rao, S., & Subramanian, S. (1997). Faster
shortest-path algorithms for planar graphs. Journal of Computer and System
Sciences. Elsevier. https://doi.org/10.1006/jcss.1997.1493
chicago: Henzinger, Monika H, Philip Klein, Satish Rao, and Sairam Subramanian.
“Faster Shortest-Path Algorithms for Planar Graphs.” Journal of Computer and
System Sciences. Elsevier, 1997. https://doi.org/10.1006/jcss.1997.1493.
ieee: M. H. Henzinger, P. Klein, S. Rao, and S. Subramanian, “Faster shortest-path
algorithms for planar graphs,” Journal of Computer and System Sciences,
vol. 55, no. 1. Elsevier, pp. 3–23, 1997.
ista: Henzinger MH, Klein P, Rao S, Subramanian S. 1997. Faster shortest-path algorithms
for planar graphs. Journal of Computer and System Sciences. 55(1), 3–23.
mla: Henzinger, Monika H., et al. “Faster Shortest-Path Algorithms for Planar Graphs.”
Journal of Computer and System Sciences, vol. 55, no. 1, Elsevier, 1997,
pp. 3–23, doi:10.1006/jcss.1997.1493.
short: M.H. Henzinger, P. Klein, S. Rao, S. Subramanian, Journal of Computer and
System Sciences 55 (1997) 3–23.
date_created: 2022-08-08T12:28:45Z
date_published: 1997-08-01T00:00:00Z
date_updated: 2022-09-12T10:46:21Z
day: '01'
doi: 10.1006/jcss.1997.1493
extern: '1'
intvolume: ' 55'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1006/jcss.1997.1493
month: '08'
oa: 1
oa_version: Published Version
page: 3-23
publication: Journal of Computer and System Sciences
publication_identifier:
issn:
- 0022-0000
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Faster shortest-path algorithms for planar graphs
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 55
year: '1997'
...