---
_id: '2981'
abstract:
- lang: eng
text: Plants contain a novel unique subfamily of Rho GTPases, vital components of
cellular signalling networks. Here we report a general role for some members of
this family in polarized plant growth processes. We show that Arabidopsis AtRop4
and AtRop6 encode functional GTPases with similar intrinsic GTP hydrolysis rates.
We localized AtRop proteins in root meristem cells to the cross-wall and cell
plate membranes. Polar localization of AtRops in trichoblasts specifies the growth
sites for emerging root hairs. These sites were visible before budding and elongation
of the Arabidopsis root hair when AtRops accumulated at their tips. Expression
of constitutively active AtRop4 and AtRop6 mutant proteins in root hairs of transgenic
Arabidopsis plants abolished polarized growth and delocalized the tip-focused
Ca2+ gradient. Polar localization of AtRops was inhibited by brefeldin A, but
not by other drugs such as latrunculin B, cytochalasin D or caffeine. Our results
demonstrate a general function of AtRop GTPases in tip growth and in polar diffuse
growth.
acknowledgement: We thank Drs Frantisek Baluška, Matthias Godde, Peter Huijser, Lars
Vahlkamp and Dieter Volkmann for help, criticism and constructive reading of the
manuscript. We are grateful to Dr N.-H.Chua for providing us with pTA7002. The work
was funded by the DFG, the European Communities Biotechnology Programme (Bio4-CT98
0239) and the INCO Copernicus Programme (IC15-CT96-0920). C.S.V.R. is the recipient
of an Alexander von Humboldt fellowship and J.F. of a DAAD fellowship.
article_processing_charge: No
article_type: original
author:
- first_name: Arthur
full_name: Molendijk, Arthur
last_name: Molendijk
- first_name: Friedrich
full_name: Bischoff, Friedrich
last_name: Bischoff
- first_name: Chadalavada
full_name: Rajendrakumar, Chadalavada
last_name: Rajendrakumar
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Markus
full_name: Braun, Markus
last_name: Braun
- first_name: Simon
full_name: Gilroy, Simon
last_name: Gilroy
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
citation:
ama: Molendijk A, Bischoff F, Rajendrakumar C, et al. Arabidopsis thaliana Rop GTPases
are localized to tips of root hairs and control polar growth. EMBO Journal.
2001;20(11):2779-2788. doi:10.1093/emboj/20.11.2779
apa: Molendijk, A., Bischoff, F., Rajendrakumar, C., Friml, J., Braun, M., Gilroy,
S., & Palme, K. (2001). Arabidopsis thaliana Rop GTPases are localized to
tips of root hairs and control polar growth. EMBO Journal. Wiley-Blackwell.
https://doi.org/10.1093/emboj/20.11.2779
chicago: Molendijk, Arthur, Friedrich Bischoff, Chadalavada Rajendrakumar, Jiří
Friml, Markus Braun, Simon Gilroy, and Klaus Palme. “Arabidopsis Thaliana Rop
GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” EMBO
Journal. Wiley-Blackwell, 2001. https://doi.org/10.1093/emboj/20.11.2779.
ieee: A. Molendijk et al., “Arabidopsis thaliana Rop GTPases are localized
to tips of root hairs and control polar growth,” EMBO Journal, vol. 20,
no. 11. Wiley-Blackwell, pp. 2779–2788, 2001.
ista: Molendijk A, Bischoff F, Rajendrakumar C, Friml J, Braun M, Gilroy S, Palme
K. 2001. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs
and control polar growth. EMBO Journal. 20(11), 2779–2788.
mla: Molendijk, Arthur, et al. “Arabidopsis Thaliana Rop GTPases Are Localized to
Tips of Root Hairs and Control Polar Growth.” EMBO Journal, vol. 20, no.
11, Wiley-Blackwell, 2001, pp. 2779–88, doi:10.1093/emboj/20.11.2779.
short: A. Molendijk, F. Bischoff, C. Rajendrakumar, J. Friml, M. Braun, S. Gilroy,
K. Palme, EMBO Journal 20 (2001) 2779–2788.
date_created: 2018-12-11T12:00:40Z
date_published: 2001-06-01T00:00:00Z
date_updated: 2023-05-16T12:07:45Z
day: '01'
doi: 10.1093/emboj/20.11.2779
extern: '1'
external_id:
pmid:
- '11387211'
intvolume: ' 20'
issue: '11'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125484/
month: '06'
oa: 1
oa_version: Published Version
page: 2779 - 2788
pmid: 1
publication: EMBO Journal
publication_identifier:
issn:
- 0261-4189
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3721'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control
polar growth
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2001'
...
---
_id: '2982'
abstract:
- lang: eng
text: Polar auxin transport is crucial for the regulation of auxin action and required
for some light-regulated responses during plant development. We have found that
two mutants of Arabidopsis - doc1, which displays altered expression of light-regulated
genes, and tir3, known for its reduced auxin transport - have similar defects
and define mutations in a single gene that we have renamed BIG. BIG is very similar
to the Drosophila gene Calossin/Pushover, a member of a gene family also present
in Caenorhabditis elegans and human genomes. The protein encoded by BIG is extraordinary
in size, 560 kD, and contains several putative Zn-finger domains. Expression-profiling
experiments indicate that altered expression of multiple light-regulated genes
in doc1 mutants can be suppressed by elevated levels of auxin caused by overexpression
of an auxin biosynthetic gene, suggesting that normal auxin distribution is required
to maintain low-level expression of these genes in the dark. Double mutants of
tir3 with the auxin mutants pin1, pid, and axr1 display severe defects in auxin-dependent
growth of the inflorescence. Chemical inhibitors of auxin transport change the
intracellular localization of the auxin efflux carrier PIN1 in doc1/tir3 mutants,
supporting the idea that BIG is required for normal auxin efflux.
acknowledgement: "We thank Kim Hanson and Melissa McCarthy for technical support,
and Adan Colon-Carmona, Jianming Li, and Karin Schumacher for their help in generating
and identifying the doc1-3 T-DNA line. Seeds of ap3-1 and a cosmid library were
supplied by the ABRC stock center. Jennifer Nemhauser made useful comments concerning
this manuscript. This work was supported by grants from the Department of Energy
(DE-FG03-89ER13993) and the National Science Foundation (MCB96-31390) to J.C., by
grants from the Department of Energy (DE-FG02-98ER20313) and the National Institutes
of Health (GM43644) to M.E., by a grant from DAAD to J.F., by a grant from DFG to
K.P., and by a Marsden grant of New Zealand to J.P. and K.S. J.C. is an Associate
Investigator of the Howard Hughes Medical Institute (HHMI), and Y.Z. is a HHMI fellow
of the Life Sciences Research Foundation.\r\n\r\nThe publication costs of this article
were defrayed in part by payment of page charges. This article must therefore be
hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate
this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Pedro
full_name: Gil, Pedro
last_name: Gil
- first_name: Elizabeth
full_name: Dewey, Elizabeth
last_name: Dewey
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Yunde
full_name: Zhao, Yunde
last_name: Zhao
- first_name: Kimberley
full_name: Snowden, Kimberley
last_name: Snowden
- first_name: Jo
full_name: Putterill, Jo
last_name: Putterill
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Mark
full_name: Estelle, Mark
last_name: Estelle
- first_name: Joanne
full_name: Chory, Joanne
last_name: Chory
citation:
ama: 'Gil P, Dewey E, Friml J, et al. BIG: A calossin-like protein required for
polar auxin transport in Arabidopsis. Genes and Development. 2001;15(15):1985-1997.
doi:10.1101/gad.905201'
apa: 'Gil, P., Dewey, E., Friml, J., Zhao, Y., Snowden, K., Putterill, J., … Chory,
J. (2001). BIG: A calossin-like protein required for polar auxin transport in
Arabidopsis. Genes and Development. Cold Spring Harbor Laboratory Press.
https://doi.org/10.1101/gad.905201'
chicago: 'Gil, Pedro, Elizabeth Dewey, Jiří Friml, Yunde Zhao, Kimberley Snowden,
Jo Putterill, Klaus Palme, Mark Estelle, and Joanne Chory. “BIG: A Calossin-like
Protein Required for Polar Auxin Transport in Arabidopsis.” Genes and Development.
Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.905201.'
ieee: 'P. Gil et al., “BIG: A calossin-like protein required for polar auxin
transport in Arabidopsis,” Genes and Development, vol. 15, no. 15. Cold
Spring Harbor Laboratory Press, pp. 1985–1997, 2001.'
ista: 'Gil P, Dewey E, Friml J, Zhao Y, Snowden K, Putterill J, Palme K, Estelle
M, Chory J. 2001. BIG: A calossin-like protein required for polar auxin transport
in Arabidopsis. Genes and Development. 15(15), 1985–1997.'
mla: 'Gil, Pedro, et al. “BIG: A Calossin-like Protein Required for Polar Auxin
Transport in Arabidopsis.” Genes and Development, vol. 15, no. 15, Cold
Spring Harbor Laboratory Press, 2001, pp. 1985–97, doi:10.1101/gad.905201.'
short: P. Gil, E. Dewey, J. Friml, Y. Zhao, K. Snowden, J. Putterill, K. Palme,
M. Estelle, J. Chory, Genes and Development 15 (2001) 1985–1997.
date_created: 2018-12-11T12:00:41Z
date_published: 2001-08-01T00:00:00Z
date_updated: 2023-05-16T11:59:47Z
day: '01'
doi: 10.1101/gad.905201
extern: '1'
external_id:
pmid:
- '11485992'
intvolume: ' 15'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312751/
month: '08'
oa: 1
oa_version: Published Version
page: 1985 - 1997
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3720'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'BIG: A calossin-like protein required for polar auxin transport in Arabidopsis'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2001'
...
---
_id: '2984'
abstract:
- lang: eng
text: Auxins represent an important class of plant hormone that regulate plant development.
Plants use specialized carrier proteins to transport the auxin indole-3-acetic
acid (IAA) to target tissues. To date, efflux carrier-mediated polar auxin transport
has been assumed to represent the sole mode of long distance IAA movement. Localization
of the auxin permease AUX1 in the Arabidopsis root apex has revealed a novel phloem-based
IAA transport pathway. AUX1, asymmetrically localized to the plasma membrane of
root protophloem cells, is proposed to promote the acropetal, post-phloem movement
of auxin to the root apex. MS analysis shows that IAA accumulation in aux1 mutant
root apices is impaired, consistent with an AUX1 phloem unloading function. AUX1
localization to columella and lateral root cap tissues of the Arabidopsis root
apex reveals that the auxin permease regulates a second IAA transport pathway.
Expression studies using an auxin-regulated reporter suggest that AUX1 is necessary
for root gravitropism by facilitating basipetal auxin transport to distal elongation
zone tissues.
acknowledgement: "We thank Ben Scheres and Marcus Grebe for critically reading the
manuscript, Burkhard Schulz for providing advice about the HA epitope tag, and Denis
Baker for valuable discussion. This work was funded by the BBSRC and European Commission
grants to the LATIN and POPWOOD research consortia.\r\n\r\nThe publication costs
of this article were defrayed in part by payment of page charges. This article must
therefore be hereby marked “advertisement” in accordance with 18 USC section 1734
solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Ranjan
full_name: Swarup, Ranjan
last_name: Swarup
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Alan
full_name: Marchant, Alan
last_name: Marchant
- first_name: Karin
full_name: Ljung, Karin
last_name: Ljung
- first_name: Göran
full_name: Sandberg, Göran
last_name: Sandberg
- first_name: Klaus
full_name: Palme, Klaus
last_name: Palme
- first_name: Malcolm
full_name: Bennett, Malcolm
last_name: Bennett
citation:
ama: Swarup R, Friml J, Marchant A, et al. Localization of the auxin permease AUX1
suggests two functionally distinct hormone transport pathways operate in the Arabidopsis
root apex. Genes and Development. 2001;15(20):2648-2653. doi:10.1101/gad.210501
apa: Swarup, R., Friml, J., Marchant, A., Ljung, K., Sandberg, G., Palme, K., &
Bennett, M. (2001). Localization of the auxin permease AUX1 suggests two functionally
distinct hormone transport pathways operate in the Arabidopsis root apex. Genes
and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.210501
chicago: Swarup, Ranjan, Jiří Friml, Alan Marchant, Karin Ljung, Göran Sandberg,
Klaus Palme, and Malcolm Bennett. “Localization of the Auxin Permease AUX1 Suggests
Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis
Root Apex.” Genes and Development. Cold Spring Harbor Laboratory Press,
2001. https://doi.org/10.1101/gad.210501.
ieee: R. Swarup et al., “Localization of the auxin permease AUX1 suggests
two functionally distinct hormone transport pathways operate in the Arabidopsis
root apex,” Genes and Development, vol. 15, no. 20. Cold Spring Harbor
Laboratory Press, pp. 2648–2653, 2001.
ista: Swarup R, Friml J, Marchant A, Ljung K, Sandberg G, Palme K, Bennett M. 2001.
Localization of the auxin permease AUX1 suggests two functionally distinct hormone
transport pathways operate in the Arabidopsis root apex. Genes and Development.
15(20), 2648–2653.
mla: Swarup, Ranjan, et al. “Localization of the Auxin Permease AUX1 Suggests Two
Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root
Apex.” Genes and Development, vol. 15, no. 20, Cold Spring Harbor Laboratory
Press, 2001, pp. 2648–53, doi:10.1101/gad.210501.
short: R. Swarup, J. Friml, A. Marchant, K. Ljung, G. Sandberg, K. Palme, M. Bennett,
Genes and Development 15 (2001) 2648–2653.
date_created: 2018-12-11T12:00:41Z
date_published: 2001-10-15T00:00:00Z
date_updated: 2023-05-16T11:37:53Z
day: '15'
doi: 10.1101/gad.210501
extern: '1'
external_id:
pmid:
- '11641271'
intvolume: ' 15'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ncbi.nlm.nih.gov/pmc/articles/PMC312818/
month: '10'
oa: 1
oa_version: Published Version
page: 2648 - 2653
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- Genes and Development
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3718'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Localization of the auxin permease AUX1 suggests two functionally distinct
hormone transport pathways operate in the Arabidopsis root apex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 15
year: '2001'
...
---
_id: '1455'
abstract:
- lang: eng
text: First, a special case of Knaster's problem is proved implying that each symmetric
convex body in ℝ3 admits an inscribed cube. It is deduced from a theorem in equivariant
topology, which says that there is no S4 - equivariant map from SO(3) to S2, where
S4 acts on SO(3) on the right as the rotation group of the cube, and on S2 on
the right as the symmetry group of the regular tetrahedron. Some generalizations
are also given. Second, it is shown how the above non-existence theorem yields
Makeev's conjecture in ℝ3 that each set in ℝ3 of diameter 1 can be covered by
a rhombic dodecahedron, which has distance 1 between its opposite faces. This
reveals an unexpected connection between inscribing cubes into symmetric bodies
and covering sets by rhombic dodecahedra. Finally, a possible application of our
second theorem to the Borsuk problem in ℝ3 is pointed out.
acknowledgement: The research of the first author was partially supported by Trinity
College, Cambridge, and that of all the authors by grants 23444, T-030012 and A
046/96, respectively, from the Hungarian National Foundation for Scientific Research.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tamas
full_name: Hausel, Tamas
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Endre
full_name: Makai, Endre
last_name: Makai
- first_name: András
full_name: Szücs, András
last_name: Szücs
citation:
ama: Hausel T, Makai E, Szücs A. Inscribing cubes and covering by rhombic dodecahedra
via equivariant topology. Mathematika. 2000;47(1-2):371-397. doi:10.1112/S0025579300015965
apa: Hausel, T., Makai, E., & Szücs, A. (2000). Inscribing cubes and covering
by rhombic dodecahedra via equivariant topology. Mathematika. University
College London. https://doi.org/10.1112/S0025579300015965
chicago: Hausel, Tamás, Endre Makai, and András Szücs. “Inscribing Cubes and Covering
by Rhombic Dodecahedra via Equivariant Topology.” Mathematika. University
College London, 2000. https://doi.org/10.1112/S0025579300015965.
ieee: T. Hausel, E. Makai, and A. Szücs, “Inscribing cubes and covering by rhombic
dodecahedra via equivariant topology,” Mathematika, vol. 47, no. 1–2. University
College London, pp. 371–397, 2000.
ista: Hausel T, Makai E, Szücs A. 2000. Inscribing cubes and covering by rhombic
dodecahedra via equivariant topology. Mathematika. 47(1–2), 371–397.
mla: Hausel, Tamás, et al. “Inscribing Cubes and Covering by Rhombic Dodecahedra
via Equivariant Topology.” Mathematika, vol. 47, no. 1–2, University College
London, 2000, pp. 371–97, doi:10.1112/S0025579300015965.
short: T. Hausel, E. Makai, A. Szücs, Mathematika 47 (2000) 371–397.
date_created: 2018-12-11T11:52:07Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-08T08:56:46Z
day: '01'
doi: 10.1112/S0025579300015965
extern: '1'
external_id:
arxiv:
- math/9906066
intvolume: ' 47'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/9906066
month: '06'
oa: 1
oa_version: Preprint
page: 371 - 397
publication: Mathematika
publication_identifier:
issn:
- 0025-5793
publication_status: published
publisher: University College London
publist_id: '5745'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Inscribing cubes and covering by rhombic dodecahedra via equivariant topology
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 47
year: '2000'
...
---
_id: '3489'
abstract:
- lang: eng
text: We have examined factors that determine the strength and dynamics of GABAergic
synapses between interneurons [dentate gyrus basket cells (BCs)] and principal
neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal
slices at 34°C. Unitary IPSCs recorded from BC–GC pairs in high intracellular
Cl− concentration showed a fast rise and a biexponential decay, with mean time
constants of 2 and 9 msec. The mean quantal conductance change, determined directly
at reduced extracellular Ca2+/Mg2+concentration ratios, was 1.7 nS. Quantal release
at the BC–GC synapse occurred with short delay and was highly synchronized. Analysis
of IPSC peak amplitudes and numbers of failures by multiple probability compound
binomial analysis indicated that synaptic transmission at the BC–GC synapse involves
three to seven release sites, each of which releases transmitter with high probability
(∼0.5 in 2 mMCa2+/1 mM Mg2+). Unitary BC–GC IPSCs showed paired-pulse depression
(PPD); maximal depression, measured for 10 msec intervals, was 37%, and recovery
from depression occurred with a time constant of 2 sec. Paired-pulse depression
was mainly presynaptic in origin but appeared to be independent of previous release.
Synaptic transmission at the BC–GC synapse showed frequency-dependent depression,
with half-maximal decrease at 5 Hz after a series of 1000 presynaptic action potentials.
The relative stability of transmission at the BC–GC synapse is consistent with
a model in which an activity-dependent gating mechanism reduces release probability
and thereby prevents depletion of the releasable pool of synaptic vesicles. Thus
several mechanisms converge on the generation of powerful and sustained transmission
at interneuron–principal neuron synapses in hippocampal circuits.
acknowledgement: This work was supported by grants from the Deutsche Forschungsgemeinschaft
(SFB 505/C5) and the Human Frontiers Science Program Organization (RG0017/1998-B)
to P.J. Novartis generously provided CGP55845A. We thank Drs. J. Bischofberger,
F. A. Edwards, J. R. P. Geiger, M. V. Jones, M. Martina, and A. Roth for critically
reading this manuscript. We also thank A. Blomenkamp for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Kraushaar U, Jonas PM. Efficacy and stability of quantal GABA release at a
hippocampal interneuron-principal neuron synapse. Journal of Neuroscience.
2000;20(15):5594-5607. doi:10.1523/JNEUROSCI.20-15-05594.2000
apa: Kraushaar, U., & Jonas, P. M. (2000). Efficacy and stability of quantal
GABA release at a hippocampal interneuron-principal neuron synapse. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000
chicago: Kraushaar, Udo, and Peter M Jonas. “Efficacy and Stability of Quantal GABA
Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of
Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000.
ieee: U. Kraushaar and P. M. Jonas, “Efficacy and stability of quantal GABA release
at a hippocampal interneuron-principal neuron synapse,” Journal of Neuroscience,
vol. 20, no. 15. Society for Neuroscience, pp. 5594–5607, 2000.
ista: Kraushaar U, Jonas PM. 2000. Efficacy and stability of quantal GABA release
at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience.
20(15), 5594–5607.
mla: Kraushaar, Udo, and Peter M. Jonas. “Efficacy and Stability of Quantal GABA
Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of
Neuroscience, vol. 20, no. 15, Society for Neuroscience, 2000, pp. 5594–607,
doi:10.1523/JNEUROSCI.20-15-05594.2000.
short: U. Kraushaar, P.M. Jonas, Journal of Neuroscience 20 (2000) 5594–5607.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-08-01T00:00:00Z
date_updated: 2023-05-03T08:18:39Z
day: '01'
doi: 10.1523/JNEUROSCI.20-15-05594.2000
extern: '1'
external_id:
pmid:
- '10908596'
intvolume: ' 20'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772523/
month: '08'
oa: 1
oa_version: Published Version
page: 5594 - 5607
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2898'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal
neuron synapse
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '3490'
abstract:
- lang: eng
text: Long-term depression (LTD) is a form of synaptic plasticity that can be induced
either by low-frequency stimulation of presynaptic fibers or in an associative
manner by asynchronous pairing of presynaptic and postsynaptic activity. We investigated
the induction mechanisms of associative LTD in CA1 pyramidal neurons of the hippocampus
using whole-cell patch-clamp recordings and Ca2+ imaging in acute brain slices.
Asynchronous pairing of postsynaptic action potentials with EPSPs evoked with
a delay of 20 msec induced a robust, long-lasting depression of the EPSP amplitude
to 43%. Unlike LTD induced by low-frequency stimulation, associative LTD was resistant
to the application of D-AP-5, indicating that it is independent of NMDA receptors.
In contrast, associative LTD was inhibited by (S)-α-methyl-4-carboxyphenyl-glycine,
indicating the involvement of metabotropic glutamate receptors. Furthermore, associative
LTD is dependent on the activation of voltage-gated Ca2+ channels by postsynaptic
action potentials. Both nifedipine, an L-type Ca2+ channel antagonist, and ω-conotoxin
GVIA, a selective N-type channel blocker, abolished the induction of associative
LTD. 8-hydroxy-2-dipropylaminotetralin (OH-DPAT), a 5-HT(1A) receptor agonist,
inhibited postsynaptic Ca2+ influx through N-type Ca2+ channels, without affecting
presynaptic transmitter release. OH-DPAT also inhibited the induction of associative
LTD, suggesting that the involvement of N-type channels makes synaptic plasticity
accessible to modulation by neurotransmitters. Thus, the modulation of N-type
Ca2+ channels provides a gain control for synaptic depression in hippocampal pyramidal
neurons.
acknowledgement: This work was supported by a grant from the Deutsche Forschungsgemeinschaft
Bi 642/1–2 and University funds (J.B.) and by the Vada and Theodore Stanley Foundation
(J.W.). We thank Drs. M. Bartos, J. R. P. Geiger, and M. Martina for critically
reading this manuscript and A. Blomenkamp for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Claus
full_name: Normann, Claus
last_name: Normann
- first_name: Diana
full_name: Peckys, Diana
last_name: Peckys
- first_name: Christian
full_name: Schulze, Christian
last_name: Schulze
- first_name: Jörg
full_name: Walden, Jörg
last_name: Walden
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
citation:
ama: Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. Associative
long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+)
channels. Journal of Neuroscience. 2000;20(22):8290-8297. doi:10.1523/JNEUROSCI.20-22-08290.2000
apa: Normann, C., Peckys, D., Schulze, C., Walden, J., Jonas, P. M., & Bischofberger,
J. (2000). Associative long-term depression in the hippocampus is dependent on
postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. Society for
Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000
chicago: Normann, Claus, Diana Peckys, Christian Schulze, Jörg Walden, Peter M Jonas,
and Joseph Bischofberger. “Associative Long-Term Depression in the Hippocampus
Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience.
Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000.
ieee: C. Normann, D. Peckys, C. Schulze, J. Walden, P. M. Jonas, and J. Bischofberger,
“Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels,” Journal of Neuroscience, vol. 20, no. 22. Society
for Neuroscience, pp. 8290–8297, 2000.
ista: Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. 2000.
Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels. Journal of Neuroscience. 20(22), 8290–8297.
mla: Normann, Claus, et al. “Associative Long-Term Depression in the Hippocampus
Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience,
vol. 20, no. 22, Society for Neuroscience, 2000, pp. 8290–97, doi:10.1523/JNEUROSCI.20-22-08290.2000.
short: C. Normann, D. Peckys, C. Schulze, J. Walden, P.M. Jonas, J. Bischofberger,
Journal of Neuroscience 20 (2000) 8290–8297.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-11-15T00:00:00Z
date_updated: 2023-05-03T08:02:52Z
day: '15'
doi: 10.1523/JNEUROSCI.20-22-08290.2000
extern: '1'
external_id:
pmid:
- '11069935'
intvolume: ' 20'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773198/
month: '11'
oa: 1
oa_version: Published Version
page: 8290 - 8297
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2897'
quality_controlled: '1'
status: public
title: Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '4270'
abstract:
- lang: eng
text: 'A coalescence-based maximum-likelihood method is presented that aims to (i)
detect diversity-reducing events in the recent history of a population and (ii)
distinguish between demographic (e.g., bottlenecks) and selective causes (selective
sweep) of a recent reduction of genetic variability. The former goal is achieved
by taking account of the distortion in the shape of gene genealogies generated
by diversity-reducing events: gene trees tend to be more star-like than under
the standard coalescent. The latter issue is addressed by comparing patterns between
loci: demographic events apply to the whole genome whereas selective events affect
distinct regions of the genome to a varying extent. The maximum-likelihood approach
allows one to estimate the time and strength of diversity-reducing events and
to choose among competing hypotheses. An application to sequence data from an
African population of Drosophila melanogaster shows that the bottleneck hypothesis
is unlikely and that one or several selective sweeps probably occurred in the
recent history of this population.'
article_processing_charge: No
article_type: original
author:
- first_name: Nicolas
full_name: Galtier, Nicolas
last_name: Galtier
- first_name: Frantz
full_name: Depaulis, Frantz
last_name: Depaulis
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Galtier N, Depaulis F, Barton NH. Detecting bottlenecks and selective sweeps
from DNA sequence polymorphism. Genetics. 2000;155(2):981-987. doi:10.1093/genetics/155.2.981
apa: Galtier, N., Depaulis, F., & Barton, N. H. (2000). Detecting bottlenecks
and selective sweeps from DNA sequence polymorphism. Genetics. Genetics
Society of America. https://doi.org/10.1093/genetics/155.2.981
chicago: Galtier, Nicolas, Frantz Depaulis, and Nicholas H Barton. “Detecting Bottlenecks
and Selective Sweeps from DNA Sequence Polymorphism.” Genetics. Genetics
Society of America, 2000. https://doi.org/10.1093/genetics/155.2.981.
ieee: N. Galtier, F. Depaulis, and N. H. Barton, “Detecting bottlenecks and selective
sweeps from DNA sequence polymorphism,” Genetics, vol. 155, no. 2. Genetics
Society of America, pp. 981–987, 2000.
ista: Galtier N, Depaulis F, Barton NH. 2000. Detecting bottlenecks and selective
sweeps from DNA sequence polymorphism. Genetics. 155(2), 981–987.
mla: Galtier, Nicolas, et al. “Detecting Bottlenecks and Selective Sweeps from DNA
Sequence Polymorphism.” Genetics, vol. 155, no. 2, Genetics Society of
America, 2000, pp. 981–87, doi:10.1093/genetics/155.2.981.
short: N. Galtier, F. Depaulis, N.H. Barton, Genetics 155 (2000) 981–987.
date_created: 2018-12-11T12:07:57Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-04-19T14:03:56Z
day: '01'
doi: 10.1093/genetics/155.2.981
extern: '1'
external_id:
pmid:
- '10835415'
intvolume: ' 155'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461106/
month: '06'
oa: 1
oa_version: None
page: 981 - 987
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1822'
status: public
title: Detecting bottlenecks and selective sweeps from DNA sequence polymorphism
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 155
year: '2000'
...
---
_id: '4274'
abstract:
- lang: eng
text: Selection on one or more genes inevitably perturbs other genes, even when
those genes have no direct effect on fitness. This article reviews the theory
of such genetic hitchhiking, concentrating on effects on neutral loci. Maynard
Smith and Haigh introduced the classical case where the perturbation is due to
a single favourable mutation. This is contrasted with the apparently distinct
effects of inherited variation in fitness due to loosely linked loci. A model
of fluctuating selection is analysed which bridges these alternative treatments.
When alleles sweep between extreme frequencies at a rate λ, the rate of drift
is increased by a factor (1 + E[1/pq]λ/(2(2λ + r))), where the recombination rate
r is much smaller than the strength of selection. In spatially structured populations,
the effects of any one substitution are weaker, and only cause a local increase
in the frequency of a neutral allele. This increase depends primarily on the rate
of recombination relative to selection (r/s), and more weakly, on the neighbourhood
size, Nb = 4πρσ2. Spatial subdivision may allow local selective sweeps to occur
more frequently than is indicated by the overall rate of molecular evolution.
However, it seems unlikely that such sweeps can be sufficiently frequent to increase
significantly the drift of neutral alleles.
acknowledgement: "I am grateful to B. Charlesworth and M.Slatkin for their helpful
comments. This work was supported by the Biotechnology\r\nand Biological Sciences
Research Council, the Natural Environment Research Council, and the Darwin Trust
of Edinburgh."
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Genetic hitchhiking. Philosophical Transactions of the Royal
Society of London Series B, Biological Sciences. 2000;355(1403):1553-1562.
doi:10.1098/rstb.2000.0716
apa: Barton, N. H. (2000). Genetic hitchhiking. Philosophical Transactions of
the Royal Society of London. Series B, Biological Sciences. Royal Society
of London. https://doi.org/10.1098/rstb.2000.0716
chicago: Barton, Nicholas H. “Genetic Hitchhiking.” Philosophical Transactions
of the Royal Society of London. Series B, Biological Sciences. Royal Society
of London, 2000. https://doi.org/10.1098/rstb.2000.0716.
ieee: N. H. Barton, “Genetic hitchhiking,” Philosophical Transactions of the
Royal Society of London. Series B, Biological Sciences, vol. 355, no. 1403.
Royal Society of London, pp. 1553–1562, 2000.
ista: Barton NH. 2000. Genetic hitchhiking. Philosophical Transactions of the Royal
Society of London. Series B, Biological Sciences. 355(1403), 1553–1562.
mla: Barton, Nicholas H. “Genetic Hitchhiking.” Philosophical Transactions of
the Royal Society of London. Series B, Biological Sciences, vol. 355, no.
1403, Royal Society of London, 2000, pp. 1553–62, doi:10.1098/rstb.2000.0716.
short: N.H. Barton, Philosophical Transactions of the Royal Society of London. Series
B, Biological Sciences 355 (2000) 1553–1562.
date_created: 2018-12-11T12:07:59Z
date_published: 2000-11-29T00:00:00Z
date_updated: 2023-04-19T09:35:31Z
day: '29'
doi: 10.1098/rstb.2000.0716
extern: '1'
external_id:
pmid:
- '11127900'
intvolume: ' 355'
issue: '1403'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1692896/
month: '11'
oa: 1
oa_version: None
page: 1553 - 1562
pmid: 1
publication: Philosophical Transactions of the Royal Society of London. Series B,
Biological Sciences
publication_identifier:
issn:
- 0962-8436
publication_status: published
publisher: Royal Society of London
publist_id: '1815'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genetic hitchhiking
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 355
year: '2000'
...
---
_id: '2342'
abstract:
- lang: eng
text: In the theoretical description of recent experiments with dilute Bose gases
confined in external potentials the Gross-Pitaevskii equation plays an important
role. Its status as an approximation for the quantum mechanical many-body ground
state problem has recently been rigorously clarified. A summary of this work is
presented here.
article_processing_charge: No
arxiv: 1
author:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: 'Seiringer R, Lieb É, Yngvason J. The ground state energy and density of interacting
bosons in a trap. In: Proceedings of the International Symposium on Quantum
Theory and Symmetries. World Scientific Publishing; 2000:101-110.'
apa: Seiringer, R., Lieb, É., & Yngvason, J. (2000). The ground state energy
and density of interacting bosons in a trap. In Proceedings of the International
Symposium on Quantum Theory and Symmetries (pp. 101–110). World Scientific
Publishing.
chicago: Seiringer, Robert, Élliott Lieb, and Jakob Yngvason. “The Ground State
Energy and Density of Interacting Bosons in a Trap.” In Proceedings of the
International Symposium on Quantum Theory and Symmetries, 101–10. World Scientific
Publishing, 2000.
ieee: R. Seiringer, É. Lieb, and J. Yngvason, “The ground state energy and density
of interacting bosons in a trap,” in Proceedings of the International Symposium
on Quantum Theory and Symmetries, 2000, pp. 101–110.
ista: 'Seiringer R, Lieb É, Yngvason J. 2000. The ground state energy and density
of interacting bosons in a trap. Proceedings of the International Symposium on
Quantum Theory and Symmetries. ISQTS: Quantum Theory and Symmetries, 101–110.'
mla: Seiringer, Robert, et al. “The Ground State Energy and Density of Interacting
Bosons in a Trap.” Proceedings of the International Symposium on Quantum Theory
and Symmetries, World Scientific Publishing, 2000, pp. 101–10.
short: R. Seiringer, É. Lieb, J. Yngvason, in:, Proceedings of the International
Symposium on Quantum Theory and Symmetries, World Scientific Publishing, 2000,
pp. 101–110.
conference:
name: 'ISQTS: Quantum Theory and Symmetries'
date_created: 2018-12-11T11:57:06Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2023-05-03T13:00:35Z
day: '01'
extern: '1'
external_id:
arxiv:
- math-ph/9911026
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/9911026
month: '06'
oa: 1
oa_version: None
page: 101 - 110
publication: Proceedings of the International Symposium on Quantum Theory and Symmetries
publication_identifier:
isbn:
- '9789810242374 '
publication_status: published
publisher: World Scientific Publishing
publist_id: '4584'
quality_controlled: '1'
status: public
title: The ground state energy and density of interacting bosons in a trap
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2000'
...
---
_id: '2343'
abstract:
- lang: eng
text: We study the energy levels of a single particle in a homogeneous magnetic
field and in an axially symmetric external potential. For potentials that are
superharmonic off the central axis, we find a general 'pseudoconcave' ordering
of the ground state energies of the Hamiltonian restricted to the sectors with
fixed angular momentum. The physical applications include atoms and ions in strong
magnetic fields. There the energies are monotone increasing and concave in angular
momentum. In the case of a periodic chain of atoms, the pseudoconcavity extends
to the entire lowest band of Bloch functions.
author:
- first_name: Bernhard
full_name: Baumgartner, Bernhard
last_name: Baumgartner
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Baumgartner B, Seiringer R. On the ordering of energy levels in homogeneous
magnetic fields. Letters in Mathematical Physics. 2000;54(3):213-226. doi: 10.1023/A:1010978807635
apa: Baumgartner, B., & Seiringer, R. (2000). On the ordering of energy levels
in homogeneous magnetic fields. Letters in Mathematical Physics. Springer.
https://doi.org/ 10.1023/A:1010978807635
chicago: Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy
Levels in Homogeneous Magnetic Fields.” Letters in Mathematical Physics.
Springer, 2000. https://doi.org/
10.1023/A:1010978807635.
ieee: B. Baumgartner and R. Seiringer, “On the ordering of energy levels in homogeneous
magnetic fields,” Letters in Mathematical Physics, vol. 54, no. 3. Springer,
pp. 213–226, 2000.
ista: Baumgartner B, Seiringer R. 2000. On the ordering of energy levels in homogeneous
magnetic fields. Letters in Mathematical Physics. 54(3), 213–226.
mla: Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels
in Homogeneous Magnetic Fields.” Letters in Mathematical Physics, vol.
54, no. 3, Springer, 2000, pp. 213–26, doi:
10.1023/A:1010978807635.
short: B. Baumgartner, R. Seiringer, Letters in Mathematical Physics 54 (2000) 213–226.
date_created: 2018-12-11T11:57:06Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2021-01-12T06:56:54Z
day: '01'
doi: ' 10.1023/A:1010978807635'
extern: 1
intvolume: ' 54'
issue: '3'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0011031
month: '11'
oa: 1
page: 213 - 226
publication: Letters in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4582'
quality_controlled: 0
status: public
title: On the ordering of energy levels in homogeneous magnetic fields
type: journal_article
volume: 54
year: '2000'
...
---
_id: '2344'
abstract:
- lang: eng
text: The ground-state properties of interacting Bose gases in external potentials,
as considered in recent experiments, are usually described by means of the Gross-Pitaevskii
energy functional. We present here a rigorous proof of the asymptotic exactness
of this approximation for the ground-state energy and particle density of a dilute
Bose gas with a positive interaction.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Élliott
full_name: Lieb, Élliott
last_name: Lieb
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: 'Lieb É, Seiringer R, Yngvason J. Bosons in a trap: A rigorous derivation of
the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular,
and Optical Physics. 2000;61(4):436021-4360213. doi:10.1103/PhysRevA.61.043602'
apa: 'Lieb, É., Seiringer, R., & Yngvason, J. (2000). Bosons in a trap: A rigorous
derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic,
Molecular, and Optical Physics. American Physical Society. https://doi.org/10.1103/PhysRevA.61.043602'
chicago: 'Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Bosons in a Trap:
A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” Physical
Review A - Atomic, Molecular, and Optical Physics. American Physical Society,
2000. https://doi.org/10.1103/PhysRevA.61.043602.'
ieee: 'É. Lieb, R. Seiringer, and J. Yngvason, “Bosons in a trap: A rigorous derivation
of the Gross-Pitaevskii energy functional,” Physical Review A - Atomic, Molecular,
and Optical Physics, vol. 61, no. 4. American Physical Society, pp. 436021–4360213,
2000.'
ista: 'Lieb É, Seiringer R, Yngvason J. 2000. Bosons in a trap: A rigorous derivation
of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular,
and Optical Physics. 61(4), 436021–4360213.'
mla: 'Lieb, Élliott, et al. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii
Energy Functional.” Physical Review A - Atomic, Molecular, and Optical Physics,
vol. 61, no. 4, American Physical Society, 2000, pp. 436021–4360213, doi:10.1103/PhysRevA.61.043602.'
short: É. Lieb, R. Seiringer, J. Yngvason, Physical Review A - Atomic, Molecular,
and Optical Physics 61 (2000) 436021–4360213.
date_created: 2018-12-11T11:57:07Z
date_published: 2000-04-01T00:00:00Z
date_updated: 2023-05-03T12:47:08Z
day: '01'
doi: 10.1103/PhysRevA.61.043602
extern: '1'
external_id:
arxiv:
- math-ph/9908027
intvolume: ' 61'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/9908027
month: '04'
oa: 1
oa_version: Published Version
page: 436021 - 4360213
publication: Physical Review A - Atomic, Molecular, and Optical Physics
publication_identifier:
issn:
- 0556-2791
publication_status: published
publisher: American Physical Society
publist_id: '4583'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 61
year: '2000'
...
---
_id: '2598'
abstract:
- lang: eng
text: "There are many types of cerebellar ataxia, including ataxia due to congenital
or metabolic disorders and a paraneoplastic form in patients with gynecologic
cancer, breast cancer, lung cancer, or Hodgkin's disease.1 This paraneoplastic
syndrome is the only type of cerebellar ataxia associated with autoantibodies
against neuronal antigens. Often, the neuronal antigens are aberrantly expressed
by the tumor cells.2-4 The antineuronal autoantibodies are believed to cause cerebellar
ataxia, but this is unproved.5,6 In Hodgkin's disease, the lymphoma precedes the
ataxia by months to years in 80 percent of patients, and ataxia often occurs during
a prolonged complete remission.4 Among patients with this type of ataxia, 30 percent
have anti–Purkinje-cell antibodies, some of which have the features of the neuronal
antibody anti-Tr.4,7\r\n\r\nWe identified a new autoantibody in two patients with
severe cerebellar ataxia that developed while they were in remission from Hodgkin's
disease. The antibody reacts specifically with the metabotropic glutamate receptor
mGluR1 in mouse brain. Metabotropic glutamate receptors belong to a large family
of cell-surface receptors that transmit signals into the cell by coupling to guanine
nucleotide-binding proteins (G proteins) in the cytoplasm. Purified IgG from the
serum of both patients blocked the glutamate-stimulated formation of inositol
phosphates in Chinese-hamster-ovary (CHO) cells that expressed mGluR1α, and the
injection of IgG from serum or cerebrospinal fluid into the cerebellar subarachnoid
space of mice caused severe, reversible ataxia. These results indicate that antineuronal
autoantibodies can cause disease of the central nervous system by blocking neuronal
receptors."
acknowledgement: "Supported in part by the Ministry of Education, Science, and Culture
of Japan (Dr. Nakanishi and Dr. Shigemoto); CREST of Japan Science and Technology
Corporation (Dr. Shigemoto); the Life Sciences Foundation (Dr. De Zeeuw); NWO (Dr.
De Zeeuw and Dr. De Leeuw); and the Human Frontier Science Program (Dr. De Zeeuw
and Dr. Shigemoto).\r\nDrs. Sillevis Smitt and Kinoshita contributed equally to
the article. We are indebted to A. Aiba for providing mGluR1-deficient mice; to
T. Maruyama for providing human mGluR1-expressing CHO cells; to H. Jingami for helpful
discussion; to A. Uesugi for photographic assistance; to M. van den Bent and C.
Gaillard for clinical information on the patients; and to J. van der Burg, S.K.E.
Koekkoek, K.J. Reus, and C. Vermeer for technical assistance."
article_processing_charge: No
article_type: original
author:
- first_name: Peter
full_name: Sillevis Smitt, Peter
last_name: Sillevis Smitt
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Bertie
full_name: De Leeuw, Bertie
last_name: De Leeuw
- first_name: Wiebe
full_name: Moll, Wiebe
last_name: Moll
- first_name: Michiel
full_name: Coesmans, Michiel
last_name: Coesmans
- first_name: Dick
full_name: Jaarsma, Dick
last_name: Jaarsma
- first_name: Sonja
full_name: Henzen Logmans, Sonja
last_name: Henzen Logmans
- first_name: Charles
full_name: Vecht, Charles
last_name: Vecht
- first_name: Chris
full_name: De Zeeuw, Chris
last_name: De Zeeuw
- first_name: Naotaka
full_name: Sekiyama, Naotaka
last_name: Sekiyama
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar
ataxia due to autoantibodies against a glutamate receptor. New England Journal
of Medicine. 2000;342(1):21-27. doi:10.1056/NEJM200001063420104
apa: Sillevis Smitt, P., Kinoshita, A., De Leeuw, B., Moll, W., Coesmans, M., Jaarsma,
D., … Shigemoto, R. (2000). Paraneoplastic cerebellar ataxia due to autoantibodies
against a glutamate receptor. New England Journal of Medicine. Massachussetts
Medical Society. https://doi.org/10.1056/NEJM200001063420104
chicago: Sillevis Smitt, Peter, Ayae Kinoshita, Bertie De Leeuw, Wiebe Moll, Michiel
Coesmans, Dick Jaarsma, Sonja Henzen Logmans, et al. “Paraneoplastic Cerebellar
Ataxia Due to Autoantibodies against a Glutamate Receptor.” New England Journal
of Medicine. Massachussetts Medical Society, 2000. https://doi.org/10.1056/NEJM200001063420104.
ieee: P. Sillevis Smitt et al., “Paraneoplastic cerebellar ataxia due to
autoantibodies against a glutamate receptor,” New England Journal of Medicine,
vol. 342, no. 1. Massachussetts Medical Society, pp. 21–27, 2000.
ista: Sillevis Smitt P, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D,
Henzen Logmans S, Vecht C, De Zeeuw C, Sekiyama N, Nakanishi S, Shigemoto R. 2000.
Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor.
New England Journal of Medicine. 342(1), 21–27.
mla: Sillevis Smitt, Peter, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies
against a Glutamate Receptor.” New England Journal of Medicine, vol. 342,
no. 1, Massachussetts Medical Society, 2000, pp. 21–27, doi:10.1056/NEJM200001063420104.
short: P. Sillevis Smitt, A. Kinoshita, B. De Leeuw, W. Moll, M. Coesmans, D. Jaarsma,
S. Henzen Logmans, C. Vecht, C. De Zeeuw, N. Sekiyama, S. Nakanishi, R. Shigemoto,
New England Journal of Medicine 342 (2000) 21–27.
date_created: 2018-12-11T11:58:35Z
date_published: 2000-01-06T00:00:00Z
date_updated: 2023-05-03T11:14:19Z
day: '06'
doi: 10.1056/NEJM200001063420104
extern: '1'
external_id:
pmid:
- '10620645'
intvolume: ' 342'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nejm.org/doi/full/10.1056/nejm200001063420104
month: '01'
oa: 1
oa_version: None
page: 21 - 27
pmid: 1
publication: New England Journal of Medicine
publication_identifier:
issn:
- 0028-4793
publication_status: published
publisher: Massachussetts Medical Society
publist_id: '4300'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate
receptor
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 342
year: '2000'
...
---
_id: '2602'
abstract:
- lang: eng
text: Although presynaptic localization of mGluR7 is well established, the mechanism
by which the receptor may control Ca2+ channels in neurons is still unknown. We
show here that cultured cerebellar granule cells express native metabotropic glutamate
receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was
also expressed in cell bodies. This allowed us to study the effect of the transfected
receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited
P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis
toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating
the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics
of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel
subunit, but was abolished by quenching βγ subunits with specific intracellular
peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action
of mGluR7, suggesting that both G-protein βγ and αo subunits were required to
mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory
action of mGluR7, suggesting that a coincident activation of PLC by the G-protein
βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition
of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC)
abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent
IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release
was required for PKC-dependent inhibition of the Ca2+ channels. Possible control
of synaptic transmission by the present mechanisms is discussed.
acknowledgement: This work was supported by Centre National de la Recherche Scientifique
and grants from Association Française contre les Myopathies, Fondation pour la Recherche
Médicale, Bayer (France), and Hoechst-Marrion-Roussel (FRHMR1/9702). We thank J.
P. Pin and F. Ango for constructive discussion of this work. We also thank Dr. J.
Saugstad (Atlanta, GA) for the rat mGluR7a cDNA, J. M. Sabatier (Marseille, France)
for the synthesis of the 68 AA peptide, V. Homburger (Montpellier, France) for the
anti-Gαo antibody, and B. Mouillac (Montpellier, France) for the anti-cMyc monoclonal
antibody.
article_processing_charge: No
article_type: original
author:
- first_name: Julie
full_name: Perroy, Julie
last_name: Perroy
- first_name: Laurent
full_name: Prezèau, Laurent
last_name: Prezèau
- first_name: Michel
full_name: De Waard, Michel
last_name: De Waard
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Joël
full_name: Bockaërt, Joël
last_name: Bockaërt
- first_name: Laurent
full_name: Fagni, Laurent
last_name: Fagni
citation:
ama: Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. Selective
blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type
7 involves a phospholipase C pathway in neurons. Journal of Neuroscience.
2000;20(21):7896-7904. doi:10.1523/JNEUROSCI.20-21-07896.2000
apa: Perroy, J., Prezèau, L., De Waard, M., Shigemoto, R., Bockaërt, J., & Fagni,
L. (2000). Selective blockade of P/Q-type calcium channels by the metabotropic
glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000
chicago: Perroy, Julie, Laurent Prezèau, Michel De Waard, Ryuichi Shigemoto, Joël
Bockaërt, and Laurent Fagni. “Selective Blockade of P/Q-Type Calcium Channels
by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway
in Neurons.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000.
ieee: J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, and L. Fagni,
“Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
receptor type 7 involves a phospholipase C pathway in neurons,” Journal of
Neuroscience, vol. 20, no. 21. Society for Neuroscience, pp. 7896–7904, 2000.
ista: Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. 2000. Selective
blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type
7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 20(21),
7896–7904.
mla: Perroy, Julie, et al. “Selective Blockade of P/Q-Type Calcium Channels by the
Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.”
Journal of Neuroscience, vol. 20, no. 21, Society for Neuroscience, 2000,
pp. 7896–904, doi:10.1523/JNEUROSCI.20-21-07896.2000.
short: J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, L. Fagni,
Journal of Neuroscience 20 (2000) 7896–7904.
date_created: 2018-12-11T11:58:37Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-03T09:48:17Z
day: '01'
doi: 10.1523/JNEUROSCI.20-21-07896.2000
extern: '1'
external_id:
pmid:
- '11050109'
intvolume: ' 20'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772734/
month: '11'
oa: 1
oa_version: Published Version
page: 7896 - 7904
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4296'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
receptor type 7 involves a phospholipase C pathway in neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '3149'
abstract:
- lang: eng
text: The prohormone convertases (PCs) are an evolutionarily ancient group of proteases
required for the maturation of neuropeptide and peptide hormone precursors. In
Drosophila melanogaster, the homolog of prohormone convertase 2, dPC2 (amontillado),
is required for normal hatching behavior, and immunoblotting data indicate that
flies express 80- and 75-kDa forms of this protein. Because mouse PC2 (mPC2) requires
7B2, a helper protein for productive maturation, we searched the fly data base
for the 7B2 signature motif PPNPCP and identified an expressed sequence tag clone
encoding the entire open reading frame for this protein. dPC2 and d7B2 cDNAs were
subcloned into expression vectors for transfection into HEK-293 cells; mPC2 and
rat 7B2 were used as controls. Although active mPC2 was detected in medium in
the presence of either d7B2 or r7B2, dPC2 showed no proteolytic activity upon
coexpression of either d7B2 or r7B2. Labeling experiments showed that dPC2 was
synthesized but not secreted from HEK-293 cells. However, when dPC2 and either
d7B2 or r7B2 were coexpressed in Drosophila S2 cells, abundant immunoreactive
dPC2 was secreted into the medium, coincident with the appearance of PC2 activity.
Expression and secretion of dPC2 enzyme activity thus appears to require insect
cell-specific posttranslational processing events. The significant differences
in the cell biology of the insect and mammalian enzymes, with 7B2 absolutely required
for secretion of dPC2 and zymogen conversion occurring intracellularly in the
case of dPC2 but not mPC2, support the idea that the Drosophila enzyme has specific
requirements for maturation and secretion that can be met only in insect cells.
acknowledgement: This work was supported by National Institutes of Health Grants DK49703
(to I. L.), NS21749 (to P. H. T.), and GM39697 (to R. S. F.). The costs of publication
of this article were defrayed in part by the payment of page charges. This article
must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section
1734 solely to indicate this fact. 10749852. We thank members of the Lindberg laboratory
and Laurent Muller for helpful comments, Bin Tu for construction of the C. elegans
PC2 expression vector, and Joelle Finley for assistance with cell culture.
article_processing_charge: No
article_type: original
author:
- first_name: Jae
full_name: Hwang, Jae
last_name: Hwang
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Robert
full_name: Fuller, Robert
last_name: Fuller
- first_name: Paul
full_name: Taghert, Paul
last_name: Taghert
- first_name: Iris
full_name: Lindberg, Iris
last_name: Lindberg
citation:
ama: 'Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. Interaction of Drosophila
melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing
and secretion. Journal of Biological Chemistry. 2000;275(23):17886-17893.
doi:10.1074/jbc.M000032200 '
apa: 'Hwang, J., Siekhaus, D. E., Fuller, R., Taghert, P., & Lindberg, I. (2000).
Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect
cell specific processing and secretion. Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M000032200 '
chicago: 'Hwang, Jae, Daria E Siekhaus, Robert Fuller, Paul Taghert, and Iris Lindberg.
“Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect
Cell Specific Processing and Secretion.” Journal of Biological Chemistry.
American Society for Biochemistry and Molecular Biology, 2000. https://doi.org/10.1074/jbc.M000032200 .'
ieee: 'J. Hwang, D. E. Siekhaus, R. Fuller, P. Taghert, and I. Lindberg, “Interaction
of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific
processing and secretion,” Journal of Biological Chemistry, vol. 275, no.
23. American Society for Biochemistry and Molecular Biology, pp. 17886–17893,
2000.'
ista: 'Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. 2000. Interaction
of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific
processing and secretion. Journal of Biological Chemistry. 275(23), 17886–17893.'
mla: 'Hwang, Jae, et al. “Interaction of Drosophila Melanogaster Prohormone Convertase
2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological
Chemistry, vol. 275, no. 23, American Society for Biochemistry and Molecular
Biology, 2000, pp. 17886–93, doi:10.1074/jbc.M000032200 .'
short: J. Hwang, D.E. Siekhaus, R. Fuller, P. Taghert, I. Lindberg, Journal of Biological
Chemistry 275 (2000) 17886–17893.
date_created: 2018-12-11T12:01:40Z
date_published: 2000-06-09T00:00:00Z
date_updated: 2023-05-03T08:47:13Z
day: '09'
doi: '10.1074/jbc.M000032200 '
extern: '1'
external_id:
pmid:
- '10749852'
intvolume: ' 275'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925819833215?via%3Dihub
month: '06'
oa: 1
oa_version: Published Version
page: 17886 - 17893
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '3546'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect
cell specific processing and secretion'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 275
year: '2000'
...
---
_id: '11127'
abstract:
- lang: eng
text: Nuclear formation in Xenopus egg extracts requires cytosol and is inhibited
by GTPγS, indicating a requirement for GTPase activity. Nuclear envelope (NE)
vesicle fusion is extensively inhibited by GTPγS and two mutant forms of the Ran
GTPase, Q69L and T24N. Depletion of either Ran or RCC1, the exchange factor for
Ran, from the assembly reaction also inhibits this step of NE formation. Ran depletion
can be complemented by the addition of Ran loaded with either GTP or GDP but not
with GTPγS. RCC1 depletion is only complemented by RCC1 itself or by RanGTP. Thus,
generation of RanGTP by RCC1 and GTP hydrolysis by Ran are both required for the
extensive membrane fusion events that lead to NE formation.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Daniel
full_name: Bilbao-Cortés, Daniel
last_name: Bilbao-Cortés
- first_name: Tobias C
full_name: Walther, Tobias C
last_name: Walther
- first_name: Oliver J
full_name: Gruss, Oliver J
last_name: Gruss
- first_name: Iain W
full_name: Mattaj, Iain W
last_name: Mattaj
citation:
ama: Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis
by Ran is required for nuclear envelope assembly. Molecular Cell. 2000;5(6):1013-1024.
doi:10.1016/s1097-2765(00)80266-x
apa: Hetzer, M., Bilbao-Cortés, D., Walther, T. C., Gruss, O. J., & Mattaj,
I. W. (2000). GTP hydrolysis by Ran is required for nuclear envelope assembly.
Molecular Cell. Elsevier. https://doi.org/10.1016/s1097-2765(00)80266-x
chicago: Hetzer, Martin, Daniel Bilbao-Cortés, Tobias C Walther, Oliver J Gruss,
and Iain W Mattaj. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly.”
Molecular Cell. Elsevier, 2000. https://doi.org/10.1016/s1097-2765(00)80266-x.
ieee: M. Hetzer, D. Bilbao-Cortés, T. C. Walther, O. J. Gruss, and I. W. Mattaj,
“GTP hydrolysis by Ran is required for nuclear envelope assembly,” Molecular
Cell, vol. 5, no. 6. Elsevier, pp. 1013–1024, 2000.
ista: Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. 2000. GTP hydrolysis
by Ran is required for nuclear envelope assembly. Molecular Cell. 5(6), 1013–1024.
mla: Hetzer, Martin, et al. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope
Assembly.” Molecular Cell, vol. 5, no. 6, Elsevier, 2000, pp. 1013–24,
doi:10.1016/s1097-2765(00)80266-x.
short: M. Hetzer, D. Bilbao-Cortés, T.C. Walther, O.J. Gruss, I.W. Mattaj, Molecular
Cell 5 (2000) 1013–1024.
date_created: 2022-04-07T07:57:59Z
date_published: 2000-06-01T00:00:00Z
date_updated: 2022-07-18T08:58:31Z
day: '01'
doi: 10.1016/s1097-2765(00)80266-x
extern: '1'
external_id:
pmid:
- '10911995'
intvolume: ' 5'
issue: '6'
keyword:
- Cell Biology
- Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S1097-2765(00)80266-X
month: '06'
oa: 1
oa_version: Published Version
page: 1013-1024
pmid: 1
publication: Molecular Cell
publication_identifier:
issn:
- 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GTP hydrolysis by Ran is required for nuclear envelope assembly
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 5
year: '2000'
...
---
_id: '11770'
abstract:
- lang: eng
text: 'We compare several algorithms for identifying mirrored hosts on the World
Wide Web. The algorithms operate on the basis of URL strings and linkage data:
the type of information about Web pages easily available from Web proxies and
crawlers. Identification of mirrored hosts can improve Web-based information retrieval
in several ways: first, by identifying mirrored hosts, search engines can avoid
storing and returning duplicate documents. Second, several new information retrieval
techniques for the Web make inferences based on the explicit links among hypertext
documents—mirroring perturbs their graph model and degrades performance. Third,
mirroring information can be used to redirect users to alternate mirror sites
to compensate for various failures, and can thus improve the performance of Web
browsers and proxies. We evaluated four classes of “top-down” algorithms for detecting
mirrored host pairs (that is, algorithms that are based on page attributes such
as URL, IP address, and hyperlinks between pages, and not on the page content)
on a collection of 140 million URLs (on 230,000 hosts) and their associated connectivity
information. Our best approach is one which combines five algorithms and achieved
a precision of 0.57 for a recall of 0.86 considering 100,000 ranked host pairs.'
article_processing_charge: No
article_type: original
author:
- first_name: Krishna
full_name: Bharat, Krishna
last_name: Bharat
- first_name: Andrei
full_name: Broder, Andrei
last_name: Broder
- first_name: Jeffrey
full_name: Dean, Jeffrey
last_name: Dean
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
citation:
ama: Bharat K, Broder A, Dean J, Henzinger MH. A comparison of techniques to find
mirrored hosts on the WWW. Journal of the American Society for Information
Science. 2000;51(12):1114-1122. doi:10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
apa: Bharat, K., Broder, A., Dean, J., & Henzinger, M. H. (2000). A comparison
of techniques to find mirrored hosts on the WWW. Journal of the American Society
for Information Science. Wiley. https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
chicago: Bharat, Krishna, Andrei Broder, Jeffrey Dean, and Monika H Henzinger. “A
Comparison of Techniques to Find Mirrored Hosts on the WWW.” Journal of the
American Society for Information Science. Wiley, 2000. https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0.
ieee: K. Bharat, A. Broder, J. Dean, and M. H. Henzinger, “A comparison of techniques
to find mirrored hosts on the WWW,” Journal of the American Society for Information
Science, vol. 51, no. 12. Wiley, pp. 1114–1122, 2000.
ista: Bharat K, Broder A, Dean J, Henzinger MH. 2000. A comparison of techniques
to find mirrored hosts on the WWW. Journal of the American Society for Information
Science. 51(12), 1114–1122.
mla: Bharat, Krishna, et al. “A Comparison of Techniques to Find Mirrored Hosts
on the WWW.” Journal of the American Society for Information Science, vol.
51, no. 12, Wiley, 2000, pp. 1114–22, doi:10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0.
short: K. Bharat, A. Broder, J. Dean, M.H. Henzinger, Journal of the American Society
for Information Science 51 (2000) 1114–1122.
date_created: 2022-08-08T12:57:37Z
date_published: 2000-10-01T00:00:00Z
date_updated: 2023-02-10T08:27:19Z
day: '01'
doi: 10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
extern: '1'
intvolume: ' 51'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0
month: '10'
oa: 1
oa_version: Published Version
page: 1114-1122
publication: Journal of the American Society for Information Science
publication_identifier:
issn:
- 0002-8231
- 1097-4571
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: A comparison of techniques to find mirrored hosts on the WWW
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 51
year: '2000'
...
---
_id: '3444'
abstract:
- lang: eng
text: This study examined intermittent, high-frequency (100-200 Hz) oscillatory
patterns in the CA1 region of the hippocampus in the absence of theta activity,
i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal
activity was phase-locked not only to large amplitude (>7 SD from baseline)
oscillatory events, which are present mainly during SPWs, but to smaller amplitude
(<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple"
frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz
("slow") oscillatory patterns. Fast ripple waves reversed just below
the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum
radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated
CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves.
These findings suggest that fast ripples emerge in the CA1 region, whereas slow
(100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred
to the CA1 field.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations
in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience.
1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Fast network oscillations in the hippocampal CA1 region of the behaving rat.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the
Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network
oscillations in the hippocampal CA1 region of the behaving rat,” Journal
of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network
oscillations in the hippocampal CA1 region of the behaving rat. Journal of
Neuroscience. 19(16).
mla: Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal
CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no.
16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999).
date_created: 2018-12-11T12:03:22Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:41:18Z
day: '15'
doi: 10.1523/JNEUROSCI.19-16-j0001.1999
extern: '1'
external_id:
pmid:
- '10436076'
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast network oscillations in the hippocampal CA1 region of the behaving
rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3445'
abstract:
- lang: eng
text: The medial septal region and the hippocampus are connected reciprocally via
GABAergic neurons, but the physiological role of this loop is still not well understood.
In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic
projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta
activity and extracellular units recorded in the medial septum and diagonal band
of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%)
were significantly suppressed during SPWs. Most cells inhibited during SPW (80%)
fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal
layer theta waves. Because both SPW and the negative peak of local theta waves
correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron
classes, the findings indicate that the activity of medial septal neurons can
be negatively (during SPW) or positively (during theta waves) correlated with
the activity of hippocampal interneurons. We hypothesize that the functional coupling
between medial septal neurons and hippocampal interneurons varies in a state-dependent
manner.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and
support and T. F. Freund for his comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Daniel
full_name: Carpi, Daniel
last_name: Carpi
- first_name: Michael
full_name: Recce, Michael
last_name: Recce
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus
and medial septum during sharp waves and theta oscillation in the behaving rat.
Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999
apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999).
Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György
Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves
and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society
for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.
ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions
between hippocampus and medial septum during sharp waves and theta oscillation
in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society
for Neuroscience, pp. 6191–6199, 1999.
ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between
hippocampus and medial septum during sharp waves and theta oscillation in the
behaving rat. Journal of Neuroscience. 19(14), 6191–6199.
mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum
during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience,
vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.
short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience
19 (1999) 6191–6199.
date_created: 2018-12-11T12:03:22Z
date_published: 1999-07-15T00:00:00Z
date_updated: 2022-09-07T13:37:41Z
day: '15'
doi: 10.1523/JNEUROSCI.19-14-06191.1999
extern: '1'
external_id:
pmid:
- '10407055'
intvolume: ' 19'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/
month: '07'
oa: 1
oa_version: Published Version
page: 6191 - 6199
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3518'
abstract:
- lang: eng
text: Information in neuronal networks may be represented by the spatiotemporal
patterns of spikes. Here we examined the temporal coordination of pyramidal cell
spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained
to run in a defined position in space (running wheel) to activate a selected group
of pyramidal cells. A template-matching method and a joint probability map method
were used for sequence search. Repeating spike sequences in excess of chance occurrence
were examined by comparing the number of repeating sequences in the original spike
trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four
different shuffling procedures were used to control for the population dynamics
of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies
were present in both the awake and sleeping animal in excess of what might be
predicted by random variations. Spike sequences observed during wheel running
were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave
sleep. We hypothesize that the endogenously expressed spike sequences during sleep
reflect reactivation of the circuitry modified by previous experience. Reactivation
of acquired sequences may serve to consolidate information.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale
Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and
Matthew Wilson for their suggestions with data analysis and comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression
of recurring spike sequences in the hippocampus. Journal of Neuroscience.
1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999
apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999).
Replay and time compression of recurring spike sequences in the hippocampus. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the
Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.
ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay
and time compression of recurring spike sequences in the hippocampus,” Journal
of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507,
1999.
ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time
compression of recurring spike sequences in the hippocampus. Journal of Neuroscience.
19(21), 9497–9507.
mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences
in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society
for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.
short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of
Neuroscience 19 (1999) 9497–9507.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-11-01T00:00:00Z
date_updated: 2022-09-07T12:48:08Z
day: '01'
doi: 10.1523/JNEUROSCI.19-21-09497.1999
extern: '1'
external_id:
pmid:
- '10531452'
intvolume: ' 19'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/
month: '11'
oa: 1
oa_version: Published Version
page: 9497 - 9507
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2866'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replay and time compression of recurring spike sequences in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3524'
abstract:
- lang: eng
text: We examined whether excitation and inhibition are balanced in hippocampal
cortical networks. Extracellular field and single-unit activity were recorded
by multiple tetrodes and multisite silicon probes to reveal the timing of the
activity of hippocampal CAI pyramidal cells and classes of interneurons during
theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and
dendritic inhibition of pyramidal cells was deduced from the activity of interneurons
in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively.
int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population
discharge of pyramidal cells during the theta cycle, respectively. SPW ripples
were associated with a 2.5-fold net increase of excitation. The discharge frequency
of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent”
cells) during SPW suggesting that not all interneurons are innervated by pyramidal
cells. Int(p) either fired together with (unimodal cells) or both before and after
(bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the
activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum
discharge probability of pyramidal neurons by 1-2 msec. Network state changes,
as reflected by field activity, covaried with changes in the spike train dynamics
of single cells and their interactions. Summed activity of parallel-recorded interneurons,
but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse
was true for the ripple cycles of SPWs. We suggest that network-driven excitability
changes provide temporal windows of opportunity for single pyramidal cells to
suppress, enable, or facilitate selective synaptic inputs.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994,
MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell
A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and
Ken Wise for supplying us with silicon probes.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal
of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving
rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons
in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience,
1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory
coupling of hippocampal pyramidal cells and interneurons in the behaving rat,”
Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp.
274–287, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of
Neuroscience. 19(1), 274–287.
mla: Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal
Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol.
19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999) 274–287.
date_created: 2018-12-11T12:03:47Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T10:00:45Z
day: '01'
doi: 10.1523/JNEUROSCI.19-01-00274.1999
extern: '1'
external_id:
pmid:
- '9870957'
intvolume: ' 19'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/
month: '01'
oa: 1
oa_version: Published Version
page: 274 - 287
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2860'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oscillatory coupling of hippocampal pyramidal cells and interneurons in the
behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...