--- _id: '3493' abstract: - lang: eng text: Although agonists and competitive antagonists presumably occupy overlapping binding sites on ligand-gated channels, these interactions cannot be identical because agonists cause channel opening whereas antagonists do not. One explanation is that only agonist binding performs enough work on the receptor to cause the conformational changes that lead to gating. This idea is supported by agonist binding rates at GABAA and nicotinic acetylcholine receptors that are slower than expected for a diffusion-limited process, suggesting that agonist binding involves an energy-requiring event. This hypothesis predicts that competitive antagonist binding should require less activation energy than agonist binding. To test this idea, we developed a novel deconvolution-based method to compare binding and unbinding kinetics of GABAA receptor agonists and antagonists in outside-out patches from rat hippocampal neurons. Agonist and antagonist unbinding rates were steeply correlated with affinity. Unlike the agonists, three of the four antagonists tested had binding rates that were fast, independent of affinity, and could be accounted for by diffusion- and dehydration-limited processes. In contrast, agonist binding involved additional energy-requiring steps, consistent with the idea that channel gating is initiated by agonist-triggered movements within the ligand binding site. Antagonist binding does not appear to produce such movements, and may in fact prevent them. article_processing_charge: No article_type: original author: - first_name: M.V full_name: Jones, M.V last_name: Jones - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Y. full_name: Sahara, Y. last_name: Sahara - first_name: G. full_name: Westbrook, G. last_name: Westbrook citation: ama: Jones M., Jonas PM, Sahara Y, Westbrook G. Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists. Biophysical Journal. 2001;81(5):2660-2670. doi:10.1016/S0006-3495(01)75909-7 apa: Jones, M. ., Jonas, P. M., Sahara, Y., & Westbrook, G. (2001). Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists. Biophysical Journal. Biophysical Society. https://doi.org/10.1016/S0006-3495(01)75909-7 chicago: Jones, M.V, Peter M Jonas, Y. Sahara, and G. Westbrook. “Microscopic Kinetics and Energetics Distinguish GABAA Receptor Agonists from Antagonists.” Biophysical Journal. Biophysical Society, 2001. https://doi.org/10.1016/S0006-3495(01)75909-7 . ieee: M. . Jones, P. M. Jonas, Y. Sahara, and G. Westbrook, “Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists,” Biophysical Journal, vol. 81, no. 5. Biophysical Society, pp. 2660–2670, 2001. ista: Jones M., Jonas PM, Sahara Y, Westbrook G. 2001. Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists. Biophysical Journal. 81(5), 2660–2670. mla: Jones, M. .., et al. “Microscopic Kinetics and Energetics Distinguish GABAA Receptor Agonists from Antagonists.” Biophysical Journal, vol. 81, no. 5, Biophysical Society, 2001, pp. 2660–70, doi:10.1016/S0006-3495(01)75909-7 . short: M.. Jones, P.M. Jonas, Y. Sahara, G. Westbrook, Biophysical Journal 81 (2001) 2660–2670. date_created: 2018-12-11T12:03:37Z date_published: 2001-11-01T00:00:00Z date_updated: 2023-05-15T13:50:21Z day: '01' doi: '10.1016/S0006-3495(01)75909-7 ' extern: '1' external_id: pmid: - '11606279' intvolume: ' 81' issue: '5' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1301733/ month: '11' oa: 1 oa_version: Published Version page: 2660 - 2670 pmid: 1 publication: Biophysical Journal publication_identifier: issn: - 0006-3495 publication_status: published publisher: Biophysical Society publist_id: '2894' quality_controlled: '1' status: public title: Microscopic kinetics and energetics distinguish GABAA receptor agonists from antagonists type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 81 year: '2001' ... --- _id: '3494' abstract: - lang: eng text: 'Mutual synaptic interactions between GABAergic interneurons are thought to be of critical importance for the generation of network oscillations and for temporal encoding of information in the hippocampus. However, the functional properties of synaptic transmission between hippocampal interneurons are largely unknown. We have made paired recordings from basket cells (BCs) in the dentate gyrus of rat hippocampal slices, followed by correlated light and electron microscopical analysis. Unitary GABAAreceptor-mediated IPSCs at BC–BC synapses recorded at the soma showed a fast rise and decay, with a mean decay time constant of 2.5 ± 0.2 msec (32°C). Synaptic transmission at BC–BC synapses showed paired-pulse depression (PPD) (32 ± 5% for 10 msec interpulse intervals) and multiple-pulse depression during repetitive stimulation. Detailed passive cable model simulations based on somatodendritic morphology and localization of synaptic contacts further indicated that the conductance change at the postsynaptic site was even faster, decaying with a mean time constant of 1.8 ± 0.6 msec. Sequential triple recordings revealed that the decay time course of IPSCs at BC–BC synapses was approximately twofold faster than that at BC–granule cell synapses, whereas the extent of PPD was comparable. To examine the consequences of the fast postsynaptic conductance change for the generation of oscillatory activity, we developed a computational model of an interneuron network. The model showed robust oscillations at frequencies >60 Hz if the excitatory drive was sufficiently large. Thus the fast conductance change at interneuron–interneuron synapses may promote the generation of high-frequency oscillations observed in the dentate gyrusin vivo. ' acknowledgement: This work was supported by grants of the Deutsche Forschungsgemeinschaft (SFB 505/C6) and the Human Frontiers Science Program Organization (RG0017/1998-B). We thank Drs. M. V. Jones, J. Bischofberger, and U. Kraushaar for critically reading this manuscript. We also thank B. Taskin and A. Roth for advice in the use of reconstruction and modeling software, and S. Nestel, M. Winter, and A. Blomenkamp for technical assistance. article_processing_charge: No article_type: original author: - first_name: Marlene full_name: Bartos, Marlene last_name: Bartos - first_name: Imre full_name: Vida, Imre last_name: Vida - first_name: Michael full_name: Frotscher, Michael last_name: Frotscher - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 citation: ama: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. 2001;21(8):2687-2698. doi:10.1523/JNEUROSCI.21-08-02687.2001 apa: Bartos, M., Vida, I., Frotscher, M., Geiger, J., & Jonas, P. M. (2001). Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001 chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Jörg Geiger, and Peter M Jonas. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001. ieee: M. Bartos, I. Vida, M. Frotscher, J. Geiger, and P. M. Jonas, “Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.,” Journal of Neuroscience, vol. 21, no. 8. Society for Neuroscience, pp. 2687–2698, 2001. ista: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. 2001. Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience. 21(8), 2687–2698. mla: Bartos, Marlene, et al. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron Network.” Journal of Neuroscience, vol. 21, no. 8, Society for Neuroscience, 2001, pp. 2687–98, doi:10.1523/JNEUROSCI.21-08-02687.2001. short: M. Bartos, I. Vida, M. Frotscher, J. Geiger, P.M. Jonas, Journal of Neuroscience 21 (2001) 2687–2698. date_created: 2018-12-11T12:03:37Z date_published: 2001-04-15T00:00:00Z date_updated: 2023-05-15T13:47:04Z day: '15' doi: 10.1523/JNEUROSCI.21-08-02687.2001 extern: '1' external_id: pmid: - '11306622' intvolume: ' 21' issue: '8' language: - iso: eng main_file_link: - open_access: '1' url: ncbi.nlm.nih.gov/pmc/articles/PMC6762544/ month: '04' oa: 1 oa_version: Published Version page: 2687 - 2698 pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2893' quality_controlled: '1' status: public title: Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network. type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 21 year: '2001' ... --- _id: '3496' abstract: - lang: eng text: 'The mossy fiber-CA3 pyramidal neuron synapse is a main component of the hippocampal trisynaptic circuitry. Recent studies, however, suggested that inhibitory interneurons are the major targets of the mossy fiber system. To study the regulation of mossy fiber-interneuron excitation, we examined unitary and compound excitatory postsynaptic currents in dentate gyrus basket cells, evoked by paired recording between granule and basket cells or extracellular stimulation of mossy fiber collaterals. The application of an associative high-frequency stimulation paradigm induced posttetanic potentiation (PTP) followed by homosynaptic long-term potentiation (LTP). Analysis of numbers of failures, coefficient of variation, and paired-pulse modulation indicated that both PTP and LTP were expressed presynaptically. The Ca2+ chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid (BAPTA) did not affect PTP or LTP at a concentration of 10 mM but attenuated LTP at a concentration of 30 mM. Both forskolin, an adenylyl cyclase activator, and phorbolester diacetate, a protein kinase C stimulator, lead to a long-lasting increase in excitatory postsynaptic current amplitude. H-89, a protein kinase A inhibitor, and bisindolylmaleimide, a protein kinase C antagonist, reduced PTP, whereas only bisindolylmaleimide reduced LTP. These results may suggest a differential contribution of protein kinase A and C pathways to mossy fiber-interneuron plasticity. Interneuron PTP and LTP may provide mechanisms to maintain the balance between synaptic excitation of interneurons and that of principal neurons in the dentate gyrus-CA3 network. ' acknowledgement: We thank Drs. J. Bischofberger and M. Martina for critically reading an earlier version of the manuscript and A. Blomenkamp for excellent technical assistance. Supported by the Deutsche Forschungsgemeinschaft Sonderforschungsbereich 505/C5 and Human Frontiers Science Program Organization Grant RG0017/98. article_processing_charge: No article_type: original author: - first_name: Henrik full_name: Alle, Henrik last_name: Alle - first_name: Peter M full_name: Jonas, Peter M id: 353C1B58-F248-11E8-B48F-1D18A9856A87 last_name: Jonas orcid: 0000-0001-5001-4804 - first_name: Jörg full_name: Geiger, Jörg last_name: Geiger citation: ama: Alle H, Jonas PM, Geiger J. PTP and LTP at a hippocampal mossy fiber-interneuron synapse. PNAS. 2001;98(25):14708-14713. doi:10.1073/pnas.251610898 apa: Alle, H., Jonas, P. M., & Geiger, J. (2001). PTP and LTP at a hippocampal mossy fiber-interneuron synapse. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.251610898 chicago: Alle, Henrik, Peter M Jonas, and Jörg Geiger. “PTP and LTP at a Hippocampal Mossy Fiber-Interneuron Synapse.” PNAS. National Academy of Sciences, 2001. https://doi.org/10.1073/pnas.251610898 . ieee: H. Alle, P. M. Jonas, and J. Geiger, “PTP and LTP at a hippocampal mossy fiber-interneuron synapse,” PNAS, vol. 98, no. 25. National Academy of Sciences, pp. 14708–14713, 2001. ista: Alle H, Jonas PM, Geiger J. 2001. PTP and LTP at a hippocampal mossy fiber-interneuron synapse. PNAS. 98(25), 14708–14713. mla: Alle, Henrik, et al. “PTP and LTP at a Hippocampal Mossy Fiber-Interneuron Synapse.” PNAS, vol. 98, no. 25, National Academy of Sciences, 2001, pp. 14708–13, doi:10.1073/pnas.251610898 . short: H. Alle, P.M. Jonas, J. Geiger, PNAS 98 (2001) 14708–14713. date_created: 2018-12-11T12:03:38Z date_published: 2001-12-04T00:00:00Z date_updated: 2023-05-15T11:08:08Z day: '04' doi: '10.1073/pnas.251610898 ' extern: '1' external_id: pmid: - '11734656' intvolume: ' 98' issue: '25' language: - iso: eng main_file_link: - open_access: '1' url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC64746/ month: '12' oa: 1 oa_version: None page: 14708 - 14713 pmid: 1 publication: PNAS publication_identifier: issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences publist_id: '2891' quality_controlled: '1' scopus_import: '1' status: public title: PTP and LTP at a hippocampal mossy fiber-interneuron synapse type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 98 year: '2001' ... --- _id: '3507' abstract: - lang: eng text: A molecular classification method is based on a space filling description of a molecule. The three dimensional body corresponding to the space filling molecular structure is divided into Voronoi regions to provide a basis for efficiently processing local structural information. A Delaunay triangulation provides a basis for systematically processing information relating to the Voronoi regions into shape descriptors in the form of topological elements. Preferably, additional shape and/or property descriptors are included in the classification method. The classification methods generally are used to identify similarities between molecules that can be used as property predictors for a variety of applications. Generally, the property predictions are the basis for selection of compounds for incorporation into efficacy evaluations. applicant: - Jie Liang, Herbert Edelsbrunner article_processing_charge: No author: - first_name: Jie full_name: Liang, Jie last_name: Liang - first_name: Herbert full_name: Edelsbrunner, Herbert id: 3FB178DA-F248-11E8-B48F-1D18A9856A87 last_name: Edelsbrunner orcid: 0000-0002-9823-6833 citation: ama: Liang J, Edelsbrunner H. Molecular classification for property prediction. 2001. apa: Liang, J., & Edelsbrunner, H. (2001). Molecular classification for property prediction. chicago: Liang, Jie, and Herbert Edelsbrunner. “Molecular Classification for Property Prediction,” 2001. ieee: J. Liang and H. Edelsbrunner, “Molecular classification for property prediction.” 2001. ista: Liang J, Edelsbrunner H. 2001. Molecular classification for property prediction. mla: Liang, Jie, and Herbert Edelsbrunner. Molecular Classification for Property Prediction. 2001. short: J. Liang, H. Edelsbrunner, (2001). date_created: 2018-12-11T12:03:41Z date_published: 2001-01-30T00:00:00Z date_updated: 2022-01-05T15:12:42Z day: '30' extern: '1' ipc: G16C20/70 ; G16B15/00 ipn: US6182016B1 main_file_link: - open_access: '1' url: https://patents.google.com/patent/US6182016B1 month: '01' oa: 1 oa_version: Published Version publication_date: 2001-01-30 publist_id: '2880' status: public title: Molecular classification for property prediction type: patent user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2001' ... --- _id: '3540' abstract: - lang: eng text: What determines the firing rate of cortical neurons in the absence of external sensory input or motor behavior, such as during sleep? Hero we report that, in a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep-wake-steep sequences. However, both measures were affected when new sets of neurons were activated in a novel environment. Nevertheless, the grand mean firing rate of the whole pyramidal cell population remained constant across behavioral states and testing conditions. The findings suggest that long-term firing patterns of single cells can be modified by experience. We hypothesize that increased firing rates of recently used neurons are associated with a concomitant decrease in the discharge activity of the remaining population, leaving the mean excitability of the hippocampal network unaltered. acknowledgement: This work was supported by National Institutes of Health Grants NS34994 and MH54671, the F. M. Kirby Foundation, the Human Frontier Science Program (X.L.), and the Uehara Memorial Foundation (H.H.). article_processing_charge: No article_type: original author: - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Xavier full_name: Leinekugel, Xavier last_name: Leinekugel - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 2001;98(16):9386-9390. doi:10.1073/pnas.161274398 apa: Hirase, H., Leinekugel, X., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (2001). Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.161274398 chicago: Hirase, Hajima, Xavier Leinekugel, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS. National Academy of Sciences, 2001. https://doi.org/10.1073/pnas.161274398. ieee: H. Hirase, X. Leinekugel, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience,” PNAS, vol. 98, no. 16. National Academy of Sciences, pp. 9386–9390, 2001. ista: Hirase H, Leinekugel X, Czurkó A, Csicsvari JL, Buzsáki G. 2001. Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience. PNAS. 98(16), 9386–9390. mla: Hirase, Hajima, et al. “Firing Rates of Hippocampal Neurons Are Preserved during Subsequent Sleep Episodes and Modified by Novel Awake Experience.” PNAS, vol. 98, no. 16, National Academy of Sciences, 2001, pp. 9386–90, doi:10.1073/pnas.161274398. short: H. Hirase, X. Leinekugel, A. Czurkó, J.L. Csicsvari, G. Buzsáki, PNAS 98 (2001) 9386–9390. date_created: 2018-12-11T12:03:52Z date_published: 2001-07-31T00:00:00Z date_updated: 2023-05-12T10:07:41Z day: '31' doi: 10.1073/pnas.161274398 extern: '1' external_id: pmid: - '11470910' intvolume: ' 98' issue: '16' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55430/ month: '07' oa: 1 oa_version: Published Version page: 9386 - 9390 pmid: 1 publication: PNAS publication_identifier: issn: - 0027-8424 publication_status: published publisher: National Academy of Sciences publist_id: '2846' quality_controlled: '1' scopus_import: '1' status: public title: Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 98 year: '2001' ... --- _id: '3546' abstract: - lang: eng text: Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a significantly stronger relationship among local (<140 <mu>m) pyramidal neurons compared with distant (>300 mum) neurons during non-theta-associated immobility and sleep but not during theta-associated running and walking. In contrast, cross-correlation between local pyramidal cell-interneuron pairs was significantly stronger than between distant pairs during theta oscillations but were similar during non-theta-associated behaviors. We suggest that network state-dependent functional clustering of neuronal activity emerges because of the differential contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta and non-theta behaviors. article_processing_charge: No article_type: original author: - first_name: Hajima full_name: Hirase, Hajima last_name: Hirase - first_name: Xavier full_name: Leinekugel, Xavier last_name: Leinekugel - first_name: Jozsef L full_name: Csicsvari, Jozsef L id: 3FA14672-F248-11E8-B48F-1D18A9856A87 last_name: Csicsvari orcid: 0000-0002-5193-4036 - first_name: András full_name: Czurkó, András last_name: Czurkó - first_name: György full_name: Buzsáki, György last_name: Buzsáki citation: ama: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 2001;21(10). doi:10.1523/JNEUROSCI.21-10-j0003.2001 apa: Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., & Buzsáki, G. (2001). Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001 chicago: Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001. ieee: H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent states of the hippocampal network affect functional clustering of neurons,” Journal of Neuroscience, vol. 21, no. 10. Society for Neuroscience, 2001. ista: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent states of the hippocampal network affect functional clustering of neurons. Journal of Neuroscience. 21(10). mla: Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network Affect Functional Clustering of Neurons.” Journal of Neuroscience, vol. 21, no. 10, Society for Neuroscience, 2001, doi:10.1523/JNEUROSCI.21-10-j0003.2001. short: H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal of Neuroscience 21 (2001). date_created: 2018-12-11T12:03:54Z date_published: 2001-05-15T00:00:00Z date_updated: 2023-05-12T09:47:39Z day: '15' doi: 10.1523/JNEUROSCI.21-10-j0003.2001 extern: '1' external_id: pmid: - '11319243' intvolume: ' 21' issue: '10' language: - iso: eng main_file_link: - open_access: '1' url: https://pubmed.ncbi.nlm.nih.gov/11319243/ month: '05' oa: 1 oa_version: Published Version pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '2839' quality_controlled: '1' scopus_import: '1' status: public title: Behavior-dependent states of the hippocampal network affect functional clustering of neurons type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 21 year: '2001' ... --- _id: '3927' abstract: - lang: eng text: TNF-alpha has been clearly identified as central mediator of T cell activation-induced acute hepatic injury in mice, e.g., Con A hepatitis. In this model, liver injury depends on both TNFRs, i.e., the 55-kDa TNFR1 as well as the 75-kDa TNFR2. We show in this report that the hepatic TNFRs are not transcriptionally regulated, but are regulated by receptor shedding. TNF directly mediates hepatocellular death by activation of TNFR1 but also induces the expression of inflammatory proteins, such as cytokines and adhesion molecules. Here we provide evidence that resistance of TNFR1(-/-) and TNFR2(-/-) mice against Con A hepatitis is not due to an impaired production of the central mediators TNF and IFN-gamma. Con A injection results in a massive induction of ICAM-1, VCAM-1, and E-selectin in the liver. Lack of either one of both TNFRs did not change adhesion molecule expression in the livers of Con A-treated mice, presumably reflecting the fact that other endothelial cell-activating cytokines up-regulated adhesion molecule expression. However, treatment of TNFR1(-/-) and TNFR2(-/-) mice with murine rTNF revealed a predominant role for TNFR1 for the induction of hepatic adhesion molecule expression. Pretreatment with blocking Abs against E- and P-selectin or of ICAM(-/-) mice with anti-VCAM-1 Abs failed to prevent Con A hepatitis, although accumulation of the critical cell population, i.e., CD4(+) T cells was significantly inhibited. Hence, up-regulation of adhesion molecules during acute hepatitis unlikely contributes to organ injury but rather represents a defense mechanism. acknowledgement: We thank Dr. H. Bluethmann (F. Hoffmann-LaRoche AG, Basle, Switzerland) for kindly providing us TNFR knockout mice. We are indebted to Dr. G. R. Adolf (Bender & Co Vienna, Austria) for providing recombinant murine TNF. We are also indebted to Dr. D. Vestweber for providing anti-P-selectin mAb (23). We thank Dr. W. Neuhuber (Institute of Anatomy, University of Erlangen-NÜrnberg, Erlangen, Germany) for experimental support regarding confocal laser scanning microscopy. The perfect technical assistance of Andrea Agli is gratefully acknowledged. article_processing_charge: No article_type: original author: - first_name: Dominik full_name: Wolf, Dominik last_name: Wolf - first_name: Rupert full_name: Hallmann, Rupert last_name: Hallmann - first_name: Gabriele full_name: Sass, Gabriele last_name: Sass - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Sabine full_name: Küsters, Sabine last_name: Küsters - first_name: Bastian full_name: Fregien, Bastian last_name: Fregien - first_name: Christian full_name: Trautwein, Christian last_name: Trautwein - first_name: Gisa full_name: Tiegs, Gisa last_name: Tiegs citation: ama: Wolf D, Hallmann R, Sass G, et al. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. 2001;166(2):1300-1307. doi:10.4049/jimmunol.166.2.1300 apa: Wolf, D., Hallmann, R., Sass, G., Sixt, M. K., Küsters, S., Fregien, B., … Tiegs, G. (2001). TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. American Association of Immunologists. https://doi.org/10.4049/jimmunol.166.2.1300 chicago: Wolf, Dominik, Rupert Hallmann, Gabriele Sass, Michael K Sixt, Sabine Küsters, Bastian Fregien, Christian Trautwein, and Gisa Tiegs. “TNF-α-Induced Expression of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.” Journal of Immunology. American Association of Immunologists, 2001. https://doi.org/10.4049/jimmunol.166.2.1300. ieee: D. Wolf et al., “TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis,” Journal of Immunology, vol. 166, no. 2. American Association of Immunologists, pp. 1300–1307, 2001. ista: Wolf D, Hallmann R, Sass G, Sixt MK, Küsters S, Fregien B, Trautwein C, Tiegs G. 2001. TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis. Journal of Immunology. 166(2), 1300–1307. mla: Wolf, Dominik, et al. “TNF-α-Induced Expression of Adhesion Molecules in the Liver Is under the Control of TNFR1--Relevance for Concanavalin A-Induced Hepatitis.” Journal of Immunology, vol. 166, no. 2, American Association of Immunologists, 2001, pp. 1300–07, doi:10.4049/jimmunol.166.2.1300. short: D. Wolf, R. Hallmann, G. Sass, M.K. Sixt, S. Küsters, B. Fregien, C. Trautwein, G. Tiegs, Journal of Immunology 166 (2001) 1300–1307. date_created: 2018-12-11T12:05:56Z date_published: 2001-01-15T00:00:00Z date_updated: 2023-05-11T13:37:29Z day: '15' doi: 10.4049/jimmunol.166.2.1300 extern: '1' external_id: pmid: - '11145713' intvolume: ' 166' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: http://www.jimmunol.org/content/166/2/1300.long month: '01' oa: 1 oa_version: None page: 1300 - 1307 pmid: 1 publication: Journal of Immunology publication_identifier: issn: - 0022-1767 publication_status: published publisher: American Association of Immunologists publist_id: '2200' quality_controlled: '1' status: public title: TNF-α-induced expression of adhesion molecules in the liver is under the control of TNFR1--relevance for concanavalin A-induced hepatitis type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 166 year: '2001' ... --- _id: '3928' abstract: - lang: eng text: Regulated adhesion of leukocytes to the extracellular matrix is essential for transmigration of blood vessels and subsequent migration into the stroma of inflamed tissues. Although beta(2)-integrins play an indisputable role in adhesion of polymorphonuclear granulocytes (PMN) to endothelium, we show here that beta(1)- and beta(3)-integrins but not beta(2)-integrin are essential for the adhesion to and migration on extracellular matrix molecules of the endothelial cell basement membrane and subjacent interstitial matrix. Mouse wild type and beta(2)-integrin null PMN and the progranulocytic cell line 32DC13 were employed in in vitro adhesion and migration assays using extracellular matrix molecules expressed at sites of extravasation in vivo, in particular the endothelial cell laminins 8 and 10. Wild type and beta(2)-integrin null PMN showed the same pattern of ECM binding, indicating that beta(2)-integrins do not mediate specific adhesion of PMN to the extracellular matrix molecules tested; binding was observed to the interstitial matrix molecules, fibronectin and vitronectin, via integrins alpha(5)beta(1) and alpha(v)beta(3), respectively; to laminin 10 via alpha(6)beta(1); but not to laminins 1, 2, and 8, collagen type I and IV, perlecan, or tenascin-C. PMN binding to laminins 1, 2, and 8 could not be induced despite surface expression of functionally active integrin alpha(6)beta(1), a major laminin receptor, demonstrating that expression of alpha(6)beta(1) alone is insufficient for ligand binding and suggesting the involvement of accessory factors. Nevertheless, laminins 1, 8, and 10 supported PMN migration, indicating that differential cellular signaling via laminins is independent of the extent of adhesion. The data demonstrate that adhesive and nonadhesive interactions with components of the endothelial cell basement membrane and subjacent interstitium play decisive roles in controlling PMN movement into sites of inflammation and illustrate that beta(2)-integrins are not essential for such interactions. acknowledgement: We thank Dr. T. Winkler for carrying out flow cytometry analysis, Dr. Simon Goodman for providing cyclic RGD peptides and helpful discussions, and Stefanie Karosi and Thomas Samson for critical review of the manuscript. This work would not have been possible without the expert technical assistance of Friederike Pausch. article_processing_charge: No article_type: original author: - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Rupert full_name: Hallmann, Rupert last_name: Hallmann - first_name: Olaf full_name: Wendler, Olaf last_name: Wendler - first_name: Karin full_name: Scharffetter Kochanek, Karin last_name: Scharffetter Kochanek - first_name: Lydia full_name: Sorokin, Lydia last_name: Sorokin citation: ama: Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. 2001;276(22):18878-18887. doi:10.1074/jbc.M010898200 apa: Sixt, M. K., Hallmann, R., Wendler, O., Scharffetter Kochanek, K., & Sorokin, L. (2001). Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M010898200 chicago: Sixt, Michael K, Rupert Hallmann, Olaf Wendler, Karin Scharffetter Kochanek, and Lydia Sorokin. “Cell Adhesion and Migration Properties of Β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance for Leukocyte Extravasation.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2001. https://doi.org/10.1074/jbc.M010898200. ieee: M. K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, and L. Sorokin, “Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation,” Journal of Biological Chemistry, vol. 276, no. 22. American Society for Biochemistry and Molecular Biology, pp. 18878–18887, 2001. ista: Sixt MK, Hallmann R, Wendler O, Scharffetter Kochanek K, Sorokin L. 2001. Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation. Journal of Biological Chemistry. 276(22), 18878–18887. mla: Sixt, Michael K., et al. “Cell Adhesion and Migration Properties of Β2-Integrin Negative Polymorphonuclear Granulocytes on Defined Extracellular Matrix Molecules. Relevance for Leukocyte Extravasation.” Journal of Biological Chemistry, vol. 276, no. 22, American Society for Biochemistry and Molecular Biology, 2001, pp. 18878–87, doi:10.1074/jbc.M010898200. short: M.K. Sixt, R. Hallmann, O. Wendler, K. Scharffetter Kochanek, L. Sorokin, Journal of Biological Chemistry 276 (2001) 18878–18887. date_created: 2018-12-11T12:05:56Z date_published: 2001-06-01T00:00:00Z date_updated: 2023-05-11T12:54:06Z day: '01' doi: 10.1074/jbc.M010898200 extern: '1' external_id: pmid: - '11278780' intvolume: ' 276' issue: '22' language: - iso: eng main_file_link: - open_access: '1' url: https://www.sciencedirect.com/science/article/pii/S0021925819670134?via%3Dihub month: '06' oa: 1 oa_version: Published Version page: 18878 - 18887 pmid: 1 publication: Journal of Biological Chemistry publication_identifier: issn: - 0021-9258 publication_status: published publisher: American Society for Biochemistry and Molecular Biology publist_id: '2199' quality_controlled: '1' scopus_import: '1' status: public title: Cell adhesion and migration properties of β2-integrin negative polymorphonuclear granulocytes on defined extracellular matrix molecules. Relevance for leukocyte extravasation type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 276 year: '2001' ... --- _id: '3930' abstract: - lang: eng text: 'An active involvement of blood-brain barrier endothelial cell basement membranes in development of inflammatory lesions in the central nervous system (CNS) has not been considered to date. Here we investigated the molecular composition and possible function of the extracellular matrix encountered by extravasating T lymphocytes during experimental autoimmune encephalomyelitis (EAE). Endothelial basement membranes contained laminin 8 (alpha4beta1gamma1) and/or 10 (alpha5beta1gamma1) and their expression was influenced by proinflammatory cytokines or angiostatic agents. T cells emigrating into the CNS during EAE encountered two biochemically distinct basement membranes, the endothelial (containing laminins 8 and 10) and the parenchymal (containing laminins 1 and 2) basement membranes. However, inflammatory cuffs occurred exclusively around endothelial basement membranes containing laminin 8, whereas in the presence of laminin 10 no infiltration was detectable. In vitro assays using encephalitogenic T cell lines revealed adhesion to laminins 8 and 10, whereas binding to laminins 1 and 2 could not be induced. Downregulation of integrin alpha6 on cerebral endothelium at sites of T cell infiltration, plus a high turnover of laminin 8 at these sites, suggested two possible roles for laminin 8 in the endothelial basement membrane: one at the level of the endothelial cells resulting in reduced adhesion and, thereby, increased penetrability of the monolayer; and secondly at the level of the T cells providing direct signals to the transmigrating cells.' acknowledgement: The authors thank Stefanie Karosi for careful and critical reading of the manuscript and Monika Bruckner for expert technical assistance. We are particularly grateful to Winfried Neuhuber for help with confocal microscopy and interpretation of the data. This work was supported by Deutsche Forschungsgemeinschaft grants So285/1-3 and So285/1-4 to L.M. Sorokin. article_processing_charge: No article_type: original author: - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 - first_name: Britta full_name: Engelhardt, Britta last_name: Engelhardt - first_name: Friederike full_name: Pausch, Friederike last_name: Pausch - first_name: Rupert full_name: Hallmann, Rupert last_name: Hallmann - first_name: Olaf full_name: Wendler, Olaf last_name: Wendler - first_name: Lydia full_name: Sorokin, Lydia last_name: Sorokin citation: ama: Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. 2001;153(5):933-946. doi:10.1083/jcb.153.5.933 apa: Sixt, M. K., Engelhardt, B., Pausch, F., Hallmann, R., Wendler, O., & Sorokin, L. (2001). Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. Rockefeller University Press. https://doi.org/10.1083/jcb.153.5.933 chicago: Sixt, Michael K, Britta Engelhardt, Friederike Pausch, Rupert Hallmann, Olaf Wendler, and Lydia Sorokin. “Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis.” Journal of Cell Biology. Rockefeller University Press, 2001. https://doi.org/10.1083/jcb.153.5.933 . ieee: M. K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, and L. Sorokin, “Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis,” Journal of Cell Biology, vol. 153, no. 5. Rockefeller University Press, pp. 933–946, 2001. ista: Sixt MK, Engelhardt B, Pausch F, Hallmann R, Wendler O, Sorokin L. 2001. Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis. Journal of Cell Biology. 153(5), 933–946. mla: Sixt, Michael K., et al. “Endothelial Cell Laminin Isoforms, Laminins 8 and 10, Play Decisive Roles in T Cell Recruitment across the Blood-Brain Barrier in Experimental Autoimmune Encephalomyelitis.” Journal of Cell Biology, vol. 153, no. 5, Rockefeller University Press, 2001, pp. 933–46, doi:10.1083/jcb.153.5.933 . short: M.K. Sixt, B. Engelhardt, F. Pausch, R. Hallmann, O. Wendler, L. Sorokin, Journal of Cell Biology 153 (2001) 933–946. date_created: 2018-12-11T12:05:57Z date_published: 2001-05-21T00:00:00Z date_updated: 2023-05-11T12:19:36Z day: '21' doi: '10.1083/jcb.153.5.933 ' extern: '1' external_id: pmid: - '11381080' intvolume: ' 153' issue: '5' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2174323/ month: '05' oa: 1 oa_version: Published Version page: 933 - 946 pmid: 1 publication: Journal of Cell Biology publication_identifier: issn: - 0021-9525 publication_status: published publisher: Rockefeller University Press publist_id: '2198' quality_controlled: '1' scopus_import: '1' status: public title: Endothelial cell laminin isoforms, laminins 8 and 10, play decisive roles in T cell recruitment across the blood-brain barrier in experimental autoimmune encephalomyelitis type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 153 year: '2001' ... --- _id: '4200' abstract: - lang: eng text: Zebrafish embryos homozygous for the masterblind (mb1) mutation exhibit a striking phenotype in which the eyes and telencephalon are reduced or absent and diencephalic fates expand to the front of the brain. Here we show that mb1(-/-) embryos carry an amino-acid change at a conserved site in the Wnt pathway scaffolding protein, Axin1. The amino-acid substitution present in the mbl allele abolishes the binding of Axin to Gsk3 and affects Tcf-dependent transcription. Therefore, Gsk3 activity may be decreased in mbl(-/-) embryos and in support of this possibility, overexpression of either wild-type Axin1 or Gsk3 beta can restore eye and telencephalic fates to mb1(-/-) embryos. Our data reveal a crucial role for Axin1-dependent inhibition of the Wnt pathway in the early regional subdivision of the anterior neural plate into telencephalic, diencephalic, and eye-forming territories. acknowledgement: "We thank many colleagues who provided reagents that enabled us to test axin1 and several other genes as candidates for the mbl mutation. In particular, we are indebted to Masahiko Hibi, Ken Irvine, Antonio Jacinto, Yun-Jin Jiang, Julian Lewis, and Tom Vogt for help and advice. We thank Ajay Chitnis and Dana Zivkovic for providing information prior to publication. This study was supported primarily by grants from the EMBO and EC to C.P.H., Wellcome Trust and EC to S.W.W., from the MRC to D.S., from Naito to M.T., from the DHGP to G.J.R. and R.G., and from the CRC/ICR to T.D. P.C. was supported by a PhD studentship from Fundação para a Ciência e Tecnologia, Programa PRAXIS XXI. S.W.W. is a Wellcome Trust Senior Research Fellow.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact." article_processing_charge: No article_type: original author: - first_name: Carl-Philipp J full_name: Heisenberg, Carl-Philipp J id: 39427864-F248-11E8-B48F-1D18A9856A87 last_name: Heisenberg orcid: 0000-0002-0912-4566 - first_name: Corinne full_name: Houart, Corinne last_name: Houart - first_name: Masaya full_name: Take Uchi, Masaya last_name: Take Uchi - first_name: Gerd full_name: Rauch, Gerd last_name: Rauch - first_name: Neville full_name: Young, Neville last_name: Young - first_name: Pedro full_name: Coutinho, Pedro last_name: Coutinho - first_name: Ichiro full_name: Masai, Ichiro last_name: Masai - first_name: Luca full_name: Caneparo, Luca last_name: Caneparo - first_name: Miguel full_name: Concha, Miguel last_name: Concha - first_name: Robert full_name: Geisler, Robert last_name: Geisler - first_name: Trevor full_name: Dale, Trevor last_name: Dale - first_name: Stephen full_name: Wilson, Stephen last_name: Wilson - first_name: Derek full_name: Stemple, Derek last_name: Stemple citation: ama: Heisenberg C-PJ, Houart C, Take Uchi M, et al. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. 2001;15(11):1427-1434. doi:10.1101/gad.194301 apa: Heisenberg, C.-P. J., Houart, C., Take Uchi, M., Rauch, G., Young, N., Coutinho, P., … Stemple, D. (2001). A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.194301 chicago: Heisenberg, Carl-Philipp J, Corinne Houart, Masaya Take Uchi, Gerd Rauch, Neville Young, Pedro Coutinho, Ichiro Masai, et al. “A Mutation in the Gsk3-Binding Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon and Eyes to Diencephalon.” Genes and Development. Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.194301. ieee: C.-P. J. Heisenberg et al., “A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon,” Genes and Development, vol. 15, no. 11. Cold Spring Harbor Laboratory Press, pp. 1427–1434, 2001. ista: Heisenberg C-PJ, Houart C, Take Uchi M, Rauch G, Young N, Coutinho P, Masai I, Caneparo L, Concha M, Geisler R, Dale T, Wilson S, Stemple D. 2001. A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon. Genes and Development. 15(11), 1427–1434. mla: Heisenberg, Carl-Philipp J., et al. “A Mutation in the Gsk3-Binding Domain of Zebrafish Masterblind/Axin1 Leads to a Fate Transformation of Telencephalon and Eyes to Diencephalon.” Genes and Development, vol. 15, no. 11, Cold Spring Harbor Laboratory Press, 2001, pp. 1427–34, doi:10.1101/gad.194301. short: C.-P.J. Heisenberg, C. Houart, M. Take Uchi, G. Rauch, N. Young, P. Coutinho, I. Masai, L. Caneparo, M. Concha, R. Geisler, T. Dale, S. Wilson, D. Stemple, Genes and Development 15 (2001) 1427–1434. date_created: 2018-12-11T12:07:33Z date_published: 2001-06-01T00:00:00Z date_updated: 2023-05-10T12:27:02Z day: '01' doi: 10.1101/gad.194301 extern: '1' external_id: pmid: - '11390362' intvolume: ' 15' issue: '11' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312705/ month: '06' oa: 1 oa_version: Published Version page: 1427 - 1434 pmid: 1 publication: Genes and Development publication_identifier: issn: - 0890-9369 publication_status: published publisher: Cold Spring Harbor Laboratory Press publist_id: '1916' quality_controlled: '1' status: public title: A mutation in the Gsk3-binding domain of zebrafish Masterblind/Axin1 leads to a fate transformation of telencephalon and eyes to diencephalon type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 15 year: '2001' ... --- _id: '2340' abstract: - lang: eng text: "Recent experimental breakthroughs in the treatment of dilute Bose gases have renewed interest in their quantum mechanical description, respectively in approximations to it. The ground state properties of dilute Bose gases confined in external potentials and interacting via repulsive short range forces are usually described by means of the Gross-Pitaevskii energy functional. In joint work with Elliott H. Lieb and Jakob Yngvason its status as an approximation for the quantum mechanical many-body ground state problem has recently been rigorously clarified. We present a summary of this work, for both the two-and three-dimensional case.\r\n" alternative_title: - 'Operator Theory: Advances and Applications' article_processing_charge: No arxiv: 1 author: - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: 'Seiringer R. Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula. In: Demuth M, Schultze B, eds. Vol 126. Birkhäuser; 2001:307-314. doi:10.1007/978-3-0348-8231-6' apa: 'Seiringer, R. (2001). Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula. In M. Demuth & B. Schultze (Eds.) (Vol. 126, pp. 307–314). Presented at the PDE: Partial Differential Equations and Spectral Theory, Clausthal, Germany: Birkhäuser. https://doi.org/10.1007/978-3-0348-8231-6' chicago: 'Seiringer, Robert. “Bosons in a Trap: Asymptotic Exactness of the Gross-Pitaevskii Ground State Energy Formula.” edited by Michael Demuth and Bert Schultze, 126:307–14. Birkhäuser, 2001. https://doi.org/10.1007/978-3-0348-8231-6.' ieee: 'R. Seiringer, “Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula,” presented at the PDE: Partial Differential Equations and Spectral Theory, Clausthal, Germany, 2001, vol. 126, pp. 307–314.' ista: 'Seiringer R. 2001. Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula. PDE: Partial Differential Equations and Spectral Theory, Operator Theory: Advances and Applications, vol. 126, 307–314.' mla: 'Seiringer, Robert. Bosons in a Trap: Asymptotic Exactness of the Gross-Pitaevskii Ground State Energy Formula. Edited by Michael Demuth and Bert Schultze, vol. 126, Birkhäuser, 2001, pp. 307–14, doi:10.1007/978-3-0348-8231-6.' short: R. Seiringer, in:, M. Demuth, B. Schultze (Eds.), Birkhäuser, 2001, pp. 307–314. conference: location: Clausthal, Germany name: 'PDE: Partial Differential Equations and Spectral Theory' date_created: 2018-12-11T11:57:05Z date_published: 2001-01-01T00:00:00Z date_updated: 2023-05-30T13:20:05Z day: '01' doi: 10.1007/978-3-0348-8231-6 editor: - first_name: Michael full_name: Demuth, Michael last_name: Demuth - first_name: Bert full_name: Schultze, Bert last_name: Schultze extern: '1' external_id: arxiv: - math-ph/0010006 intvolume: ' 126' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0010006 month: '01' oa: 1 oa_version: None page: 307 - 314 publication_identifier: isbn: - '9783034894838' publication_status: published publisher: Birkhäuser publist_id: '4586' quality_controlled: '1' status: public title: 'Bosons in a trap: Asymptotic exactness of the Gross-Pitaevskii ground state energy formula' type: conference user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 126 year: '2001' ... --- _id: '2341' abstract: - lang: eng text: We study the ground state properties of an atom with nuclear charge Z and N bosonic "electrons" in the presence of a homogeneous magnetic field B. We investigate the mean field limit N→∞ with N / Z fixed, and identify three different asymptotic regions, according to B≪Z2,B∼Z2,andB≫Z2 . In Region 1 standard Hartree theory is applicable. Region 3 is described by a one-dimensional functional, which is identical to the so-called Hyper-Strong functional introduced by Lieb, Solovej and Yngvason for atoms with fermionic electrons in the region B≫Z3 ; i.e., for very strong magnetic fields the ground state properties of atoms are independent of statistics. For Region 2 we introduce a general magnetic Hartree functional, which is studied in detail. It is shown that in the special case of an atom it can be restricted to the subspace of zero angular momentum parallel to the magnetic field, which simplifies the theory considerably. The functional reproduces the energy and the one-particle reduced density matrix for the full N-particle ground state to leading order in N, and it implies the description of the other regions as limiting cases. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Bernhard full_name: Baumgartner, Bernhard last_name: Baumgartner - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Baumgartner B, Seiringer R. Atoms with bosonic &quot;electrons&quot; in strong magnetic fields. Annales Henri Poincare. 2001;2(1):41-76. doi:10.1007/PL00001032 apa: Baumgartner, B., & Seiringer, R. (2001). Atoms with bosonic &quot;electrons&quot; in strong magnetic fields. Annales Henri Poincare. Birkhäuser. https://doi.org/10.1007/PL00001032 chicago: Baumgartner, Bernhard, and Robert Seiringer. “Atoms with Bosonic &quot;Electrons&quot; in Strong Magnetic Fields.” Annales Henri Poincare. Birkhäuser, 2001. https://doi.org/10.1007/PL00001032. ieee: B. Baumgartner and R. Seiringer, “Atoms with bosonic &quot;electrons&quot; in strong magnetic fields,” Annales Henri Poincare, vol. 2, no. 1. Birkhäuser, pp. 41–76, 2001. ista: Baumgartner B, Seiringer R. 2001. Atoms with bosonic &quot;electrons&quot; in strong magnetic fields. Annales Henri Poincare. 2(1), 41–76. mla: Baumgartner, Bernhard, and Robert Seiringer. “Atoms with Bosonic &quot;Electrons&quot; in Strong Magnetic Fields.” Annales Henri Poincare, vol. 2, no. 1, Birkhäuser, 2001, pp. 41–76, doi:10.1007/PL00001032. short: B. Baumgartner, R. Seiringer, Annales Henri Poincare 2 (2001) 41–76. date_created: 2018-12-11T11:57:06Z date_published: 2001-02-01T00:00:00Z date_updated: 2023-05-30T12:49:08Z day: '01' doi: 10.1007/PL00001032 extern: '1' external_id: arxiv: - math-ph/0007007 intvolume: ' 2' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0007007 month: '02' oa: 1 oa_version: None page: 41 - 76 publication: Annales Henri Poincare publication_identifier: issn: - 1424-0637 publication_status: published publisher: Birkhäuser publist_id: '4585' quality_controlled: '1' scopus_import: '1' status: public title: Atoms with bosonic "electrons" in strong magnetic fields type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 2 year: '2001' ... --- _id: '2345' abstract: - lang: eng text: We give upper bounds for the number of spin-1/2 particles that can be bound to a nucleus of charge Z in the presence of a magnetic field B, including the spin-field coupling. We use Lieb's strategy, which is known to yield Nc < 2Z + 1 for magnetic fields that go to zero at infinity, ignoring the spin-field interaction. For particles with fermionic statistics in a homogeneous magnetic field our upper bound has an additional term of the order of Z × min {(B/Z3)2/5, 1 + | 1n(B/Z3)|2}. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: 'Seiringer R. On the maximal ionization of atoms in strong magnetic fields. Journal of Physics A: Mathematical and General. 2001;34(9):1943-1948. doi:10.1088/0305-4470/34/9/311' apa: 'Seiringer, R. (2001). On the maximal ionization of atoms in strong magnetic fields. Journal of Physics A: Mathematical and General. IOP Publishing Ltd. https://doi.org/10.1088/0305-4470/34/9/311' chicago: 'Seiringer, Robert. “On the Maximal Ionization of Atoms in Strong Magnetic Fields.” Journal of Physics A: Mathematical and General. IOP Publishing Ltd., 2001. https://doi.org/10.1088/0305-4470/34/9/311.' ieee: 'R. Seiringer, “On the maximal ionization of atoms in strong magnetic fields,” Journal of Physics A: Mathematical and General, vol. 34, no. 9. IOP Publishing Ltd., pp. 1943–1948, 2001.' ista: 'Seiringer R. 2001. On the maximal ionization of atoms in strong magnetic fields. Journal of Physics A: Mathematical and General. 34(9), 1943–1948.' mla: 'Seiringer, Robert. “On the Maximal Ionization of Atoms in Strong Magnetic Fields.” Journal of Physics A: Mathematical and General, vol. 34, no. 9, IOP Publishing Ltd., 2001, pp. 1943–48, doi:10.1088/0305-4470/34/9/311.' short: 'R. Seiringer, Journal of Physics A: Mathematical and General 34 (2001) 1943–1948.' date_created: 2018-12-11T11:57:07Z date_published: 2001-03-09T00:00:00Z date_updated: 2023-05-30T12:37:44Z day: '09' doi: 10.1088/0305-4470/34/9/311 extern: '1' external_id: arxiv: - math-ph/0006002 intvolume: ' 34' issue: '9' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0006002 month: '03' oa: 1 oa_version: None page: 1943 - 1948 publication: 'Journal of Physics A: Mathematical and General' publication_identifier: issn: - 0305-4470 publication_status: published publisher: IOP Publishing Ltd. publist_id: '4580' quality_controlled: '1' scopus_import: '1' status: public title: On the maximal ionization of atoms in strong magnetic fields type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 34 year: '2001' ... --- _id: '2346' abstract: - lang: eng text: By means of a generalization of the Fefferman - de la Llave decomposition we derive a general lower bound on the interaction energy of one-dimensional quantum systems. We apply this result to a specific class of lowest Landau band wave functions. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Christian full_name: Hainzl, Christian last_name: Hainzl - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Hainzl C, Seiringer R. Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics. Letters in Mathematical Physics. 2001;55(2):133-142. doi:10.1023/A:1010951905548 apa: Hainzl, C., & Seiringer, R. (2001). Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics. Letters in Mathematical Physics. Springer. https://doi.org/10.1023/A:1010951905548 chicago: Hainzl, Christian, and Robert Seiringer. “Bounds on One-Dimensional Exchange Energies with Application to Lowest Landau Band Quantum Mechanics.” Letters in Mathematical Physics. Springer, 2001. https://doi.org/10.1023/A:1010951905548. ieee: C. Hainzl and R. Seiringer, “Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics,” Letters in Mathematical Physics, vol. 55, no. 2. Springer, pp. 133–142, 2001. ista: Hainzl C, Seiringer R. 2001. Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics. Letters in Mathematical Physics. 55(2), 133–142. mla: Hainzl, Christian, and Robert Seiringer. “Bounds on One-Dimensional Exchange Energies with Application to Lowest Landau Band Quantum Mechanics.” Letters in Mathematical Physics, vol. 55, no. 2, Springer, 2001, pp. 133–42, doi:10.1023/A:1010951905548. short: C. Hainzl, R. Seiringer, Letters in Mathematical Physics 55 (2001) 133–142. date_created: 2018-12-11T11:57:07Z date_published: 2001-02-01T00:00:00Z date_updated: 2023-05-30T12:44:05Z day: '01' doi: 10.1023/A:1010951905548 extern: '1' external_id: arxiv: - cond-mat/0102118 intvolume: ' 55' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/cond-mat/0102118 month: '02' oa: 1 oa_version: Published Version page: 133 - 142 publication: Letters in Mathematical Physics publication_identifier: issn: - 0377-9017 publication_status: published publisher: Springer publist_id: '4581' quality_controlled: '1' scopus_import: '1' status: public title: Bounds on one-dimensional exchange energies with application to lowest Landau band quantum mechanics type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 55 year: '2001' ... --- _id: '2347' abstract: - lang: eng text: We consider the ground state properties of an inhomogeneous two-dimensional Bose gas with a repulsive, short range pair interaction and an external confining potential. In the limit when the particle number N is large but ρ̅a 2 is small, where ρ̅ is the average particle density and a the scattering length, the ground state energy and density are rigorously shown to be given to leading order by a Gross–Pitaevskii (GP) energy functional with a coupling constant g~1/|1n(ρ̅a 2)|. In contrast to the 3D case the coupling constant depends on N through the mean density. The GP energy per particle depends only on Ng. In 2D this parameter is typically so large that the gradient term in the GP energy functional is negligible and the simpler description by a Thomas–Fermi type functional is adequate. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Élliott full_name: Lieb, Élliott last_name: Lieb - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 - first_name: Jakob full_name: Yngvason, Jakob last_name: Yngvason citation: ama: Lieb É, Seiringer R, Yngvason J. A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas. Communications in Mathematical Physics. 2001;224(1):17-31. doi:10.1007/s002200100533 apa: Lieb, É., Seiringer, R., & Yngvason, J. (2001). A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas. Communications in Mathematical Physics. Springer. https://doi.org/10.1007/s002200100533 chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “A Rigorous Derivation of the Gross-Pitaevskii Energy Functional for a Two-Dimensional Bose Gas.” Communications in Mathematical Physics. Springer, 2001. https://doi.org/10.1007/s002200100533. ieee: É. Lieb, R. Seiringer, and J. Yngvason, “A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas,” Communications in Mathematical Physics, vol. 224, no. 1. Springer, pp. 17–31, 2001. ista: Lieb É, Seiringer R, Yngvason J. 2001. A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas. Communications in Mathematical Physics. 224(1), 17–31. mla: Lieb, Élliott, et al. “A Rigorous Derivation of the Gross-Pitaevskii Energy Functional for a Two-Dimensional Bose Gas.” Communications in Mathematical Physics, vol. 224, no. 1, Springer, 2001, pp. 17–31, doi:10.1007/s002200100533. short: É. Lieb, R. Seiringer, J. Yngvason, Communications in Mathematical Physics 224 (2001) 17–31. date_created: 2018-12-11T11:57:08Z date_published: 2001-11-01T00:00:00Z date_updated: 2023-05-30T12:28:46Z day: '01' doi: 10.1007/s002200100533 extern: '1' external_id: arxiv: - cond-mat/0005026 intvolume: ' 224' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/cond-mat/0005026 month: '11' oa: 1 oa_version: Published Version page: 17 - 31 publication: Communications in Mathematical Physics publication_identifier: issn: - 0010-3616 publication_status: published publisher: Springer publist_id: '4579' quality_controlled: '1' scopus_import: '1' status: public title: A rigorous derivation of the Gross-Pitaevskii energy functional for a two-dimensional Bose gas type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 224 year: '2001' ... --- _id: '2348' abstract: - lang: eng text: This paper concerns the asymptotic ground state properties of heavy atoms in strong, homogeneous magnetic fields. In the limit when the nuclear charge Z tends to ∞ with the magnetic field B satisfying B ≫ Z4/3 all the electrons are confined to the lowest Landau band. We consider here an energy functional, whose variable is a sequence of one-dimensional density matrices corresponding to different angular momentum functions in the lowest Landau band. We study this functional in detail and derive various interesting properties, which are compared with the density matrix (DM) theory introduced by Lieb, Solovej and Yngvason. In contrast to the DM theory the variable perpendicular to the field is replaced by the discrete angular momentum quantum numbers. Hence we call the new functional a discrete density matrix (DDM) functional. We relate this DDM theory to the lowest Landau band quantum mechanics and show that it reproduces correctly the ground state energy apart from errors due to the indirect part of the Coulomb interaction energy. acknowledgement: The authors would like to thank Bernhard Baumgartner and Jakob Yngvason for proofreading and valuable comments. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Christian full_name: Hainzl, Christian last_name: Hainzl - first_name: Robert full_name: Seiringer, Robert id: 4AFD0470-F248-11E8-B48F-1D18A9856A87 last_name: Seiringer orcid: 0000-0002-6781-0521 citation: ama: Hainzl C, Seiringer R. A discrete density matrix theory for atoms in strong magnetic fields. Communications in Mathematical Physics. 2001;217(1):229-248. doi:10.1007/s002200100373 apa: Hainzl, C., & Seiringer, R. (2001). A discrete density matrix theory for atoms in strong magnetic fields. Communications in Mathematical Physics. Springer. https://doi.org/10.1007/s002200100373 chicago: Hainzl, Christian, and Robert Seiringer. “A Discrete Density Matrix Theory for Atoms in Strong Magnetic Fields.” Communications in Mathematical Physics. Springer, 2001. https://doi.org/10.1007/s002200100373. ieee: C. Hainzl and R. Seiringer, “A discrete density matrix theory for atoms in strong magnetic fields,” Communications in Mathematical Physics, vol. 217, no. 1. Springer, pp. 229–248, 2001. ista: Hainzl C, Seiringer R. 2001. A discrete density matrix theory for atoms in strong magnetic fields. Communications in Mathematical Physics. 217(1), 229–248. mla: Hainzl, Christian, and Robert Seiringer. “A Discrete Density Matrix Theory for Atoms in Strong Magnetic Fields.” Communications in Mathematical Physics, vol. 217, no. 1, Springer, 2001, pp. 229–48, doi:10.1007/s002200100373. short: C. Hainzl, R. Seiringer, Communications in Mathematical Physics 217 (2001) 229–248. date_created: 2018-12-11T11:57:08Z date_published: 2001-02-01T00:00:00Z date_updated: 2023-05-30T06:54:54Z day: '01' doi: 10.1007/s002200100373 extern: '1' external_id: arxiv: - math-ph/0010005 intvolume: ' 217' issue: '1' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0010005 month: '02' oa: 1 oa_version: Preprint page: 229 - 248 publication: Communications in Mathematical Physics publication_identifier: issn: - 0010-3616 publication_status: published publisher: Springer publist_id: '4578' quality_controlled: '1' scopus_import: '1' status: public title: A discrete density matrix theory for atoms in strong magnetic fields type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 217 year: '2001' ... --- _id: '2610' abstract: - lang: eng text: To study the role of mGlu7 receptors (mGluR7), we used homologous recombination to generate mice lacking this metabotropic receptor subtype (mGluR7 -/-). After the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype, we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals aged 12 weeks and older, subthreshold doses of these drugs induced seizures in mGluR7 -/-, but not in mGluR7 +/-, mice. PTZ-induced seizures were inhibited by three standard anticonvulsant drugs, but not by the group III selective mGluR agonist (R,S)-4-phosphonophenylglycine (PPG). Consistent with the lack of signs of epileptic activity in the absence of specific stimuli, mGluR7 -/- mice showed no major changes in synaptic properties in two slice preparations. However, slightly increased excitability was evident in hippocampal slices. In addition, there was slower recovery from frequency facilitation in cortical slices, suggesting a role for mGluR7 as a frequency-dependent regulator in presynaptic terminals. Our findings suggest that mGluR7 receptors have a unique role in regulating neuronal excitability and that these receptors may be a novel target for the development of anticonvulsant drugs. acknowledgement: This work was supported in part by the Biotechnology and Biological Sciences Research Council and Medical Research Council (UK). We thank Doris Ruegg for sequencing, Gemma Texido and Klaus Rajewsky for pTV-0 DNA, J.-F. Pin for mGluR8 cDNA, K. von Figura for E14 ES cells, Pedro Grandes for histological examination of brain sections, Christoph Wiessner for help with plots and statistics, Valerie Schuler for help with Western blots, and the team of the Novartis special strain breeding facility for their support. article_processing_charge: No article_type: original author: - first_name: Gilles full_name: Sansig, Gilles last_name: Sansig - first_name: Trevor full_name: Bushell, Trevor last_name: Bushell - first_name: Vernon full_name: Clarke, Vernon last_name: Clarke - first_name: Andrei full_name: Rozov, Andrei last_name: Rozov - first_name: Nail full_name: Burnashev, Nail last_name: Burnashev - first_name: Chantal full_name: Portet, Chantal last_name: Portet - first_name: Fabrizio full_name: Gasparini, Fabrizio last_name: Gasparini - first_name: Markus full_name: Schmutz, Markus last_name: Schmutz - first_name: Klaus full_name: Klebs, Klaus last_name: Klebs - first_name: Ryuichi full_name: Shigemoto, Ryuichi id: 499F3ABC-F248-11E8-B48F-1D18A9856A87 last_name: Shigemoto orcid: 0000-0001-8761-9444 - first_name: Peter full_name: Flor, Peter last_name: Flor - first_name: Rainer full_name: Kühn, Rainer last_name: Kühn - first_name: Thomas full_name: Knoepfel, Thomas last_name: Knoepfel - first_name: Markus full_name: Schroeder, Markus last_name: Schroeder - first_name: David full_name: Hampson, David last_name: Hampson - first_name: Valerie full_name: Collett, Valerie last_name: Collett - first_name: Congxiao full_name: Zhang, Congxiao last_name: Zhang - first_name: Robert full_name: Duvoisin, Robert last_name: Duvoisin - first_name: Graham full_name: Collingridge, Graham last_name: Collingridge - first_name: Herman full_name: Van Der Putten, Herman last_name: Van Der Putten citation: ama: Sansig G, Bushell T, Clarke V, et al. Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 2001;21(22):8734-8745. doi:10.1523/JNEUROSCI.21-22-08734.2001 apa: Sansig, G., Bushell, T., Clarke, V., Rozov, A., Burnashev, N., Portet, C., … Van Der Putten, H. (2001). Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001 chicago: Sansig, Gilles, Trevor Bushell, Vernon Clarke, Andrei Rozov, Nail Burnashev, Chantal Portet, Fabrizio Gasparini, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001. ieee: G. Sansig et al., “Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7,” Journal of Neuroscience, vol. 21, no. 22. Society for Neuroscience, pp. 8734–8745, 2001. ista: Sansig G, Bushell T, Clarke V, Rozov A, Burnashev N, Portet C, Gasparini F, Schmutz M, Klebs K, Shigemoto R, Flor P, Kühn R, Knoepfel T, Schroeder M, Hampson D, Collett V, Zhang C, Duvoisin R, Collingridge G, Van Der Putten H. 2001. Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 21(22), 8734–8745. mla: Sansig, Gilles, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7.” Journal of Neuroscience, vol. 21, no. 22, Society for Neuroscience, 2001, pp. 8734–45, doi:10.1523/JNEUROSCI.21-22-08734.2001. short: G. Sansig, T. Bushell, V. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini, M. Schmutz, K. Klebs, R. Shigemoto, P. Flor, R. Kühn, T. Knoepfel, M. Schroeder, D. Hampson, V. Collett, C. Zhang, R. Duvoisin, G. Collingridge, H. Van Der Putten, Journal of Neuroscience 21 (2001) 8734–8745. date_created: 2018-12-11T11:58:39Z date_published: 2001-11-15T00:00:00Z date_updated: 2023-05-24T08:47:53Z day: '15' doi: 10.1523/JNEUROSCI.21-22-08734.2001 extern: '1' external_id: pmid: - '11698585' intvolume: ' 21' issue: '22' language: - iso: eng main_file_link: - open_access: '1' url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762269/ month: '11' oa: 1 oa_version: Published Version page: 8734 - 8745 pmid: 1 publication: Journal of Neuroscience publication_identifier: issn: - 0270-6474 publication_status: published publisher: Society for Neuroscience publist_id: '4288' quality_controlled: '1' scopus_import: '1' status: public title: Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7 type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 21 year: '2001' ... --- _id: '2734' abstract: - lang: eng text: In this paper we describe an intrinsically geometric way of producing magnetic fields on S3 and R3 for which the corresponding Dirac operators have a non-trivial kernel. In many cases we are able to compute the dimension of the kernel. In particular we can give examples where the kernel has any given dimension. This generalizes the examples of Loss and Yau [1]. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Jan full_name: Solovej, Jan last_name: Solovej citation: ama: Erdös L, Solovej J. The kernel of Dirac operators on S3 and R3. Reviews in Mathematical Physics. 2001;13(10):1247-1280. doi:10.1142/S0129055X01000983 apa: Erdös, L., & Solovej, J. (2001). The kernel of Dirac operators on S3 and R3. Reviews in Mathematical Physics. World Scientific Publishing. https://doi.org/10.1142/S0129055X01000983 chicago: Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and R3.” Reviews in Mathematical Physics. World Scientific Publishing, 2001. https://doi.org/10.1142/S0129055X01000983. ieee: L. Erdös and J. Solovej, “The kernel of Dirac operators on S3 and R3,” Reviews in Mathematical Physics, vol. 13, no. 10. World Scientific Publishing, pp. 1247–1280, 2001. ista: Erdös L, Solovej J. 2001. The kernel of Dirac operators on S3 and R3. Reviews in Mathematical Physics. 13(10), 1247–1280. mla: Erdös, László, and Jan Solovej. “The Kernel of Dirac Operators on S3 and R3.” Reviews in Mathematical Physics, vol. 13, no. 10, World Scientific Publishing, 2001, pp. 1247–80, doi:10.1142/S0129055X01000983. short: L. Erdös, J. Solovej, Reviews in Mathematical Physics 13 (2001) 1247–1280. date_created: 2018-12-11T11:59:19Z date_published: 2001-10-01T00:00:00Z date_updated: 2023-05-16T12:24:25Z day: '01' doi: 10.1142/S0129055X01000983 extern: '1' external_id: arxiv: - math-ph/0001036 intvolume: ' 13' issue: '10' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/math-ph/0001036 month: '10' oa: 1 oa_version: Published Version page: 1247 - 1280 publication: Reviews in Mathematical Physics publication_identifier: issn: - 0129-055X publication_status: published publisher: World Scientific Publishing publist_id: '4158' quality_controlled: '1' scopus_import: '1' status: public title: The kernel of Dirac operators on S3 and R3 type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 13 year: '2001' ... --- _id: '2735' abstract: - lang: eng text: We establish the exact low-energy asymptotics of the integrated density of states (Lifschitz tail) in a homogeneous magnetic field and Poissonian impurities with a repulsive single-site potential of Gaussian decay. It has been known that the Gaussian potential tail discriminates between the so-called “classical” and “quantum” regimes, and precise asymptotics are known in these cases. For the borderline case, the coexistence of the classical and quantum regimes was conjectured. Here we settle this last remaining open case to complete the full picture of the magnetic Lifschitz tails. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 citation: ama: 'Erdös L. Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. Probability Theory and Related Fields. 2001;121(2):219-236. doi:10.1007/PL00008803' apa: 'Erdös, L. (2001). Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. Probability Theory and Related Fields. Springer. https://doi.org/10.1007/PL00008803' chicago: 'Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical and Quantum Behavior in the Borderline Case.” Probability Theory and Related Fields. Springer, 2001. https://doi.org/10.1007/PL00008803.' ieee: 'L. Erdös, “Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case,” Probability Theory and Related Fields, vol. 121, no. 2. Springer, pp. 219–236, 2001.' ista: 'Erdös L. 2001. Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case. Probability Theory and Related Fields. 121(2), 219–236.' mla: 'Erdös, László. “Lifschitz Tail in a Magnetic Field: Coexistence of Classical and Quantum Behavior in the Borderline Case.” Probability Theory and Related Fields, vol. 121, no. 2, Springer, 2001, pp. 219–36, doi:10.1007/PL00008803.' short: L. Erdös, Probability Theory and Related Fields 121 (2001) 219–236. date_created: 2018-12-11T11:59:19Z date_published: 2001-10-01T00:00:00Z date_updated: 2023-05-16T12:20:42Z day: '01' doi: 10.1007/PL00008803 extern: '1' external_id: arxiv: - math-ph/0003023 intvolume: ' 121' issue: '2' language: - iso: eng main_file_link: - open_access: '1' url: https://arxiv.org/abs/math-ph/0003023 month: '10' oa: 1 oa_version: Published Version page: 219 - 236 publication: Probability Theory and Related Fields publication_identifier: issn: - 0044-3719 publication_status: published publisher: Springer publist_id: '4157' quality_controlled: '1' scopus_import: '1' status: public title: 'Lifschitz tail in a magnetic field: Coexistence of classical and quantum behavior in the borderline case' type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 121 year: '2001' ... --- _id: '2736' abstract: - lang: eng text: We consider the time evolution of N bosonic particles interacting via a mean field Coulomb potential. Suppose the initial state is a product wavefunction. We show that at any finite time the correlation functions factorize in the limit N → ∞. Furthermore, the limiting one particle density matrix satisfies the nonlinear Hartree equation. The key ingredients are the uniqueness of the BBGKY hierarchy for the correlation functions and a new apriori estimate for the many-body Schrödinger equations. article_processing_charge: No article_type: original arxiv: 1 author: - first_name: László full_name: Erdös, László id: 4DBD5372-F248-11E8-B48F-1D18A9856A87 last_name: Erdös orcid: 0000-0001-5366-9603 - first_name: Horng full_name: Yau, Horng last_name: Yau citation: ama: Erdös L, Yau H. Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. Advances in Theoretical and Mathematical Physics. 2001;5(6):1169-1205. doi:10.48550/arXiv.math-ph/0111042 apa: Erdös, L., & Yau, H. (2001). Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. Advances in Theoretical and Mathematical Physics. International Press. https://doi.org/10.48550/arXiv.math-ph/0111042 chicago: Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger Equation from a Many Body Coulomb System.” Advances in Theoretical and Mathematical Physics. International Press, 2001. https://doi.org/10.48550/arXiv.math-ph/0111042. ieee: L. Erdös and H. Yau, “Derivation of the nonlinear Schrödinger equation from a many body Coulomb system,” Advances in Theoretical and Mathematical Physics, vol. 5, no. 6. International Press, pp. 1169–1205, 2001. ista: Erdös L, Yau H. 2001. Derivation of the nonlinear Schrödinger equation from a many body Coulomb system. Advances in Theoretical and Mathematical Physics. 5(6), 1169–1205. mla: Erdös, László, and Horng Yau. “Derivation of the Nonlinear Schrödinger Equation from a Many Body Coulomb System.” Advances in Theoretical and Mathematical Physics, vol. 5, no. 6, International Press, 2001, pp. 1169–205, doi:10.48550/arXiv.math-ph/0111042. short: L. Erdös, H. Yau, Advances in Theoretical and Mathematical Physics 5 (2001) 1169–1205. date_created: 2018-12-11T11:59:20Z date_published: 2001-11-01T00:00:00Z date_updated: 2023-05-16T12:12:41Z day: '01' doi: 10.48550/arXiv.math-ph/0111042 extern: '1' external_id: arxiv: - math-ph/0111042 intvolume: ' 5' issue: '6' language: - iso: eng main_file_link: - open_access: '1' url: http://arxiv.org/abs/math-ph/0111042 month: '11' oa: 1 oa_version: Published Version page: 1169 - 1205 publication: Advances in Theoretical and Mathematical Physics publication_identifier: issn: - 1095-0761 publication_status: published publisher: International Press publist_id: '4156' quality_controlled: '1' scopus_import: '1' status: public title: Derivation of the nonlinear Schrödinger equation from a many body Coulomb system type: journal_article user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17 volume: 5 year: '2001' ...