---
_id: '4258'
abstract:
- lang: eng
  text: We studied the effect of multilocus balancing selection on neutral nucleotide
    variability at linked sites by simulating a model where diallelic polymorphisms
    are maintained at an arbitrary number of selected loci by means of symmetric overdominance.
    Different combinations of alleles define different genetic backgrounds that subdivide
    the population and strongly affect variability. Several multilocus fitness regimes
    with different degrees of epistasis and gametic disequilibrium are allowed. Analytical
    results based on a multilocus extension of the structured coalescent predict that
    the expected linked neutral diversity increases exponentially with the number
    of selected loci and can become extremely large. Our simulation results show that
    although variability increases with the number of genetic backgrounds that are
    maintained in the population, it is reduced by random fluctuations in the frequencies
    of those backgrounds and does not reach high levels even in very large populations.
    We also show that previous results on balancing selection in single-locus systems
    do not extend to the multilocus scenario in a straightforward way. Different patterns
    of linkage disequilibrium and of the frequency spectrum of neutral mutations are
    expected under different degrees of epistasis. Interestingly, the power to detect
    balancing selection using deviations from a neutral distribution of allele frequencies
    seems to be diminished under the fitness regime that leads to the largest increase
    of variability over the neutral case. This and other results are discussed in
    the light of data from the Mhc.
acknowledgement: We thank P. Andolfatto, P. Awadalla, B. Charlesworth, D. Charles-
  Guillaudeux, T., M. Janer, G. K. S. Wong, T. Spies and D. E. Geraghty, F. Depaulis,
  S. Otto, J. Rozas, and three anonymous reviewers for valuable discussion and criticism.
  A.N. is grateful to F. Depaulis, whose comments were particularly helpful (and extremely
  funny), and to D. Charlesworth, whose ideas made this work readable. This work was
  supported by Biotechnology and Biological Sciences Research Council/Engineering
  and Physical Sciences Research Council.
article_processing_charge: No
article_type: original
author:
- first_name: Arcadio
  full_name: Navarro, Arcadio
  last_name: Navarro
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Navarro A, Barton NH. The effects of multilocus balancing selection on neutral
    variability. <i>Genetics</i>. 2002;161(2):849-863. doi:<a href="https://doi.org/10.1093/genetics/161.2.849">10.1093/genetics/161.2.849</a>
  apa: Navarro, A., &#38; Barton, N. H. (2002). The effects of multilocus balancing
    selection on neutral variability. <i>Genetics</i>. Genetics Society of America.
    <a href="https://doi.org/10.1093/genetics/161.2.849">https://doi.org/10.1093/genetics/161.2.849</a>
  chicago: Navarro, Arcadio, and Nicholas H Barton. “The Effects of Multilocus Balancing
    Selection on Neutral Variability.” <i>Genetics</i>. Genetics Society of America,
    2002. <a href="https://doi.org/10.1093/genetics/161.2.849">https://doi.org/10.1093/genetics/161.2.849</a>.
  ieee: A. Navarro and N. H. Barton, “The effects of multilocus balancing selection
    on neutral variability,” <i>Genetics</i>, vol. 161, no. 2. Genetics Society of
    America, pp. 849–863, 2002.
  ista: Navarro A, Barton NH. 2002. The effects of multilocus balancing selection
    on neutral variability. Genetics. 161(2), 849–863.
  mla: Navarro, Arcadio, and Nicholas H. Barton. “The Effects of Multilocus Balancing
    Selection on Neutral Variability.” <i>Genetics</i>, vol. 161, no. 2, Genetics
    Society of America, 2002, pp. 849–63, doi:<a href="https://doi.org/10.1093/genetics/161.2.849">10.1093/genetics/161.2.849</a>.
  short: A. Navarro, N.H. Barton, Genetics 161 (2002) 849–863.
date_created: 2018-12-11T12:07:53Z
date_published: 2002-06-01T00:00:00Z
date_updated: 2023-06-06T12:02:32Z
day: '01'
doi: 10.1093/genetics/161.2.849
extern: '1'
external_id:
  pmid:
  - '12072479'
intvolume: '       161'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462137/
month: '06'
oa: 1
oa_version: Published Version
page: 849 - 863
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1835'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effects of multilocus balancing selection on neutral variability
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 161
year: '2002'
...
---
_id: '4259'
abstract:
- lang: eng
  text: 'We extend current multilocus models to describe the effects of migration,
    recombination, selection, and nonrandom mating on sets of genes in diploids with
    varied modes of inheritance, allowing us to consider the patterns of nuclear and
    cytonuclear associations (disequilibria) under various models of migration. We
    show the relationship between the multilocus notation recently presented by Kirkpatrick,
    Johnson, and Barton (developed from previous work by Barton and Turelli) and the
    cytonuclear parameterization of Asmussen, Arnold, and Avise and extend this notation
    to describe associations between cytoplasmic elements and multiple nuclear genes.
    Under models with sexual symmetry, both nuclear-nuclear and cytonuclear disequilibria
    are equivalent. They differ, however, in cases involving some type of sexual asymmetry,
    which is then reflected in the asymmetric inheritance of cytoplasmic markers.
    An example given is the case of different migration rates in males and females;
    simulations using 2, 3, 4, or 5 unlinked autosomal markers with a maternally inherited
    cytoplasmic marker illustrate how nuclear-nuclear and cytonuclear associations
    can be used to separately estimate female and male migration rates. The general
    framework developed here allows us to investigate conditions where associations
    between loci with different modes of inheritance are not equivalent and to use
    this nonequivalence to test for deviations from simple models of admixture. '
acknowledgement: The authors thank Toby Johnson for his helpful comments on this manuscript.
  This work was supported by a National Science Foundation NATO postdoctoral fellowship
  and National Science Foundation grants DEB-9813335 and DEB-0108242 to M.E.O.; N.H.B.
  gratefully acknowledges the support of the Darwin Trust of Edinburgh and the National
  Environmental Research Council.
article_processing_charge: No
article_type: original
author:
- first_name: Maria
  full_name: Orive, Maria
  last_name: Orive
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Orive M, Barton NH. Associations between cytoplasmic and nuclear loci in hybridizing
    populations. <i>Genetics</i>. 2002;162(3):1469-1485. doi:<a href="https://doi.org/10.1093/genetics/162.3.1469">10.1093/genetics/162.3.1469</a>
  apa: Orive, M., &#38; Barton, N. H. (2002). Associations between cytoplasmic and
    nuclear loci in hybridizing populations. <i>Genetics</i>. Genetics Society of
    America. <a href="https://doi.org/10.1093/genetics/162.3.1469">https://doi.org/10.1093/genetics/162.3.1469</a>
  chicago: Orive, Maria, and Nicholas H Barton. “Associations between Cytoplasmic
    and Nuclear Loci in Hybridizing Populations.” <i>Genetics</i>. Genetics Society
    of America, 2002. <a href="https://doi.org/10.1093/genetics/162.3.1469">https://doi.org/10.1093/genetics/162.3.1469</a>.
  ieee: M. Orive and N. H. Barton, “Associations between cytoplasmic and nuclear loci
    in hybridizing populations,” <i>Genetics</i>, vol. 162, no. 3. Genetics Society
    of America, pp. 1469–1485, 2002.
  ista: Orive M, Barton NH. 2002. Associations between cytoplasmic and nuclear loci
    in hybridizing populations. Genetics. 162(3), 1469–1485.
  mla: Orive, Maria, and Nicholas H. Barton. “Associations between Cytoplasmic and
    Nuclear Loci in Hybridizing Populations.” <i>Genetics</i>, vol. 162, no. 3, Genetics
    Society of America, 2002, pp. 1469–85, doi:<a href="https://doi.org/10.1093/genetics/162.3.1469">10.1093/genetics/162.3.1469</a>.
  short: M. Orive, N.H. Barton, Genetics 162 (2002) 1469–1485.
date_created: 2018-12-11T12:07:54Z
date_published: 2002-11-01T00:00:00Z
date_updated: 2023-06-06T12:19:54Z
day: '01'
doi: 10.1093/genetics/162.3.1469
extern: '1'
external_id:
  pmid:
  - '12454089'
intvolume: '       162'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462324/
month: '11'
oa: 1
oa_version: Published Version
page: 1469 - 1485
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1836'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Associations between cytoplasmic and nuclear loci in hybridizing populations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 162
year: '2002'
...
---
_id: '4260'
abstract:
- lang: eng
  text: 'We calculate the fixation probability of a beneficial allele that arises
    as the result of a unique mutation in an asexual population that is subject to
    recurrent deleterious mutation at rate U. Our analysis is an extension of previous
    works, which make a biologically restrictive assumption that selection against
    deleterious alleles is stronger than that on the beneficial allele of interest.
    We show that when selection against deleterious alleles is weak, beneficial alleles
    that confer a selective advantage that is small relative to U have greatly reduced
    probabilities of fixation. We discuss the consequences of this effect for the
    distribution of effects of alleles fixed during adaptation. We show that a selective
    sweep will increase the fixation probabilities of other beneficial mutations arising
    during some short interval afterward. We use the calculated fixation probabilities
    to estimate the expected rate of fitness improvement in an asexual population
    when beneficial alleles arise continually at some low rate proportional to U.
    We estimate the rate of mutation that is optimal in the sense that it maximizes
    this rate of fitness improvement. Again, this analysis relaxes the assumption
    made previously that selection against deleterious alleles is stronger than on
    beneficial alleles. '
acknowledgement: "We thank Brian Charlesworth, Arcadi Navarro, Allen Orr, Sally Otto,
  Mario Pineda-Krch, Rosie Redfield, Olivier Tenaillon, and two anonymous reviewers
  for discussions and/or helpful comments on the\r\nmanuscript. T.J. is supported
  by Wellcome Trust International Prize Travelling Research Fellowship no. 061530.
  N.B. is supported by the Biotechnology and Biological Sciences Research Council
  and by the Natural Environment Research Council."
article_processing_charge: No
article_type: original
author:
- first_name: Toby
  full_name: Johnson, Toby
  last_name: Johnson
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Johnson T, Barton NH. The effect of deleterious alleles on adaptation in asexual
    populations. <i>Genetics</i>. 2002;162(1):395-411. doi:<a href="https://doi.org/10.1093/genetics/162.1.395">10.1093/genetics/162.1.395</a>
  apa: Johnson, T., &#38; Barton, N. H. (2002). The effect of deleterious alleles
    on adaptation in asexual populations. <i>Genetics</i>. Genetics Society of America.
    <a href="https://doi.org/10.1093/genetics/162.1.395">https://doi.org/10.1093/genetics/162.1.395</a>
  chicago: Johnson, Toby, and Nicholas H Barton. “The Effect of Deleterious Alleles
    on Adaptation in Asexual Populations.” <i>Genetics</i>. Genetics Society of America,
    2002. <a href="https://doi.org/10.1093/genetics/162.1.395">https://doi.org/10.1093/genetics/162.1.395</a>.
  ieee: T. Johnson and N. H. Barton, “The effect of deleterious alleles on adaptation
    in asexual populations,” <i>Genetics</i>, vol. 162, no. 1. Genetics Society of
    America, pp. 395–411, 2002.
  ista: Johnson T, Barton NH. 2002. The effect of deleterious alleles on adaptation
    in asexual populations. Genetics. 162(1), 395–411.
  mla: Johnson, Toby, and Nicholas H. Barton. “The Effect of Deleterious Alleles on
    Adaptation in Asexual Populations.” <i>Genetics</i>, vol. 162, no. 1, Genetics
    Society of America, 2002, pp. 395–411, doi:<a href="https://doi.org/10.1093/genetics/162.1.395">10.1093/genetics/162.1.395</a>.
  short: T. Johnson, N.H. Barton, Genetics 162 (2002) 395–411.
date_created: 2018-12-11T12:07:54Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-06-06T11:45:48Z
day: '01'
doi: 10.1093/genetics/162.1.395
extern: '1'
external_id:
  pmid:
  - '12242249'
intvolume: '       162'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462245/
month: '09'
oa: 1
oa_version: None
page: 395 - 411
pmid: 1
publication: Genetics
publication_identifier:
  issn:
  - 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '1833'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effect of deleterious alleles on adaptation in asexual populations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 162
year: '2002'
...
---
_id: '4474'
abstract:
- lang: eng
  text: 'The simulation preorder for labeled transition systems is defined locally,
    and operationally, as a game that relates states with their immediate successor
    states. Simulation enjoys many appealing properties. First, simulation has a denotational
    characterization: system S simulates system I iff every computation tree embedded
    in the unrolling of I can be embedded also in the unrolling of S. Second, simulation
    has a logical characterization: S simulates I iff every universal branching-time
    formula satisfied by S is satisfied also by I. It follows that simulation is a
    suitable notion of implementation, and it is the coarsest abstraction of a system
    that preserves universal branching-time properties. Third, based on its local
    definition, simulation between finite-state systems can be checked in polynomial
    time. Finally, simulation implies trace containment, which cannot be defined locally
    and requires polynomial space for verification. Hence simulation is widely used
    both in manual and in automatic verification. Liveness assumptions about transition
    systems are typically modeled using fairness constraints. Existing notions of
    simulation for fair transition systems, however, are not local, and as a result,
    many appealing properties of the simulation preorder are lost. We propose a new
    view of fair simulation by extending the local definition of simulation to account
    for fairness: system View the MathML sourcefairly simulates system View the MathML
    source iff in the simulation game, there is a strategy that matches with each
    fair computation of View the MathML source a fair computation of View the MathML
    source. Our definition enjoys a denotational characterization and has a logical
    characterization: View the MathML source fairly simulates View the MathML source
    iff every fair computation tree (whose infinite paths are fair) embedded in the
    unrolling of View the MathML source can be embedded also in the unrolling of View
    the MathML source or, equivalently, iff every Fair-∀AFMC formula satisfied by
    View the MathML source is satisfied also by View the MathML source (∀AFMC is the
    universal fragment of the alternation-free μ-calculus). The locality of the definition
    leads us to a polynomial-time algorithm for checking fair simulation for finite-state
    systems with weak and strong fairness constraints. Finally, fair simulation implies
    fair trace containment and is therefore useful as an efficiently computable local
    criterion for proving linear-time abstraction hierarchies of fair systems.'
acknowledgement: We thank Ramin Hojati, Doron Bustan, and the anonymous reviewers
  for their comments on this paper.
article_processing_charge: No
article_type: original
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Orna
  full_name: Kupferman, Orna
  last_name: Kupferman
- first_name: Sriram
  full_name: Rajamani, Sriram
  last_name: Rajamani
citation:
  ama: Henzinger TA, Kupferman O, Rajamani S. Fair simulation. <i>Information and
    Computation</i>. 2002;173(1):64-81. doi:<a href="https://doi.org/10.1006/inco.2001.3085">10.1006/inco.2001.3085</a>
  apa: Henzinger, T. A., Kupferman, O., &#38; Rajamani, S. (2002). Fair simulation.
    <i>Information and Computation</i>. Elsevier. <a href="https://doi.org/10.1006/inco.2001.3085">https://doi.org/10.1006/inco.2001.3085</a>
  chicago: Henzinger, Thomas A, Orna Kupferman, and Sriram Rajamani. “Fair Simulation.”
    <i>Information and Computation</i>. Elsevier, 2002. <a href="https://doi.org/10.1006/inco.2001.3085">https://doi.org/10.1006/inco.2001.3085</a>.
  ieee: T. A. Henzinger, O. Kupferman, and S. Rajamani, “Fair simulation,” <i>Information
    and Computation</i>, vol. 173, no. 1. Elsevier, pp. 64–81, 2002.
  ista: Henzinger TA, Kupferman O, Rajamani S. 2002. Fair simulation. Information
    and Computation. 173(1), 64–81.
  mla: Henzinger, Thomas A., et al. “Fair Simulation.” <i>Information and Computation</i>,
    vol. 173, no. 1, Elsevier, 2002, pp. 64–81, doi:<a href="https://doi.org/10.1006/inco.2001.3085">10.1006/inco.2001.3085</a>.
  short: T.A. Henzinger, O. Kupferman, S. Rajamani, Information and Computation 173
    (2002) 64–81.
date_created: 2018-12-11T12:09:02Z
date_published: 2002-02-25T00:00:00Z
date_updated: 2023-06-05T07:53:27Z
day: '25'
doi: 10.1006/inco.2001.3085
extern: '1'
intvolume: '       173'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.sciencedirect.com/science/article/pii/S0890540101930858?via%3Dihub
month: '02'
oa: 1
oa_version: Published Version
page: 64 - 81
publication: Information and Computation
publication_identifier:
  issn:
  - 0890-5401
publication_status: published
publisher: Elsevier
publist_id: '255'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fair simulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 173
year: '2002'
...
---
_id: '2338'
abstract:
- lang: eng
  text: Now that the low temperature properties of quantum-mechanical many-body systems
    (bosons) at low density, ρ, can be examined experimentally it is appropriate to
    revisit some of the formulas deduced by many authors 4-5 decades ago. For systems
    with repulsive (i.e. positive) interaction potentials the experimental low temperature
    state and the ground state are effectively synonymous -- and this fact is used
    in all modeling. In such cases, the leading term in the energy/particle is 2πℏ2aρ/m
    where a is the scattering length of the two-body potential. Owing to the delicate
    and peculiar nature of bosonic correlations (such as the strange N7/5 law for
    charged bosons), four decades of research failed to establish this plausible formula
    rigorously. The only previous lower bound for the energy was found by Dyson in
    1957, but it was 14 times too small. The correct asymptotic formula has recently
    been obtained by us and this work will be presented. The reason behind the mathematical
    difficulties will be emphasized. A different formula, postulated as late as 1971
    by Schick, holds in two-dimensions and this, too, will be shown to be correct.
    With the aid of the methodology developed to prove the lower bound for the homogeneous
    gas, two other problems have been successfully addressed. One is the proof by
    us that the Gross-Pitaevskii equation correctly describes the ground state in
    the `traps' actually used in the experiments. For this system it is also possible
    to prove complete Bose condensation, as we have shown. Another topic is a proof
    that Foldy's 1961 theory of a high density Bose gas of charged particles correctly
    describes its ground state energy.
alternative_title:
- Current Developments in Mathematics
article_processing_charge: No
arxiv: 1
author:
- first_name: Élliott
  full_name: Lieb, Élliott
  last_name: Lieb
- first_name: Jan
  full_name: Solovej, Jan
  last_name: Solovej
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
- first_name: Jakob
  full_name: Yngvason, Jakob
  last_name: Yngvason
citation:
  ama: 'Lieb É, Solovej J, Seiringer R, Yngvason J. The ground state of the Bose gas.
    In: <i>Current Developments in Mathematics, 2001</i>. International Press; 2002:131-178.
    doi:<a href="https://doi.org/10.48550/arXiv.math-ph/0204027">10.48550/arXiv.math-ph/0204027</a>'
  apa: Lieb, É., Solovej, J., Seiringer, R., &#38; Yngvason, J. (2002). The ground
    state of the Bose gas. In <i>Current Developments in Mathematics, 2001</i> (pp.
    131–178). International Press. <a href="https://doi.org/10.48550/arXiv.math-ph/0204027">https://doi.org/10.48550/arXiv.math-ph/0204027</a>
  chicago: Lieb, Élliott, Jan Solovej, Robert Seiringer, and Jakob Yngvason. “The
    Ground State of the Bose Gas.” In <i>Current Developments in Mathematics, 2001</i>,
    131–78. International Press, 2002. <a href="https://doi.org/10.48550/arXiv.math-ph/0204027">https://doi.org/10.48550/arXiv.math-ph/0204027</a>.
  ieee: É. Lieb, J. Solovej, R. Seiringer, and J. Yngvason, “The ground state of the
    Bose gas,” in <i>Current Developments in Mathematics, 2001</i>, International
    Press, 2002, pp. 131–178.
  ista: 'Lieb É, Solovej J, Seiringer R, Yngvason J. 2002.The ground state of the
    Bose gas. In: Current Developments in Mathematics, 2001. Current Developments
    in Mathematics, , 131–178.'
  mla: Lieb, Élliott, et al. “The Ground State of the Bose Gas.” <i>Current Developments
    in Mathematics, 2001</i>, International Press, 2002, pp. 131–78, doi:<a href="https://doi.org/10.48550/arXiv.math-ph/0204027">10.48550/arXiv.math-ph/0204027</a>.
  short: É. Lieb, J. Solovej, R. Seiringer, J. Yngvason, in:, Current Developments
    in Mathematics, 2001, International Press, 2002, pp. 131–178.
date_created: 2018-12-11T11:57:04Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-26T08:43:46Z
day: '01'
doi: 10.48550/arXiv.math-ph/0204027
extern: '1'
external_id:
  arxiv:
  - math-ph/0204027
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math-ph/0204027
month: '01'
oa: 1
oa_version: Published Version
page: 131 - 178
publication: Current Developments in Mathematics, 2001
publication_identifier:
  isbn:
  - '9781571461018'
publication_status: published
publisher: International Press
publist_id: '4588'
status: public
title: The ground state of the Bose gas
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
year: '2002'
...
---
_id: '2349'
abstract:
- lang: eng
  text: The Bose-Einstein condensation (BEC) of the ground state of bosonic atoms
    in a trap was discussed. The BEC was proved for bosons with two-body repulsive
    interaction potentials in the dilute limit, starting from the basic Schrodinger
    equation. The BEC was 100% into the state which minimized the Gross-Pitaevskii
    energy functional. The analysis also included rigorous proof of BEC in a physically
    realistic, continuum model.
author:
- first_name: Élliott
  full_name: Lieb, Élliott H
  last_name: Lieb
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Lieb É, Seiringer R. Proof of Bose-Einstein condensation for dilute trapped
    gases. <i>Physical Review Letters</i>. 2002;88(17):1704091-1704094. doi:<a href="https://doi.org/10.1103/PhysRevLett.88.170409">10.1103/PhysRevLett.88.170409</a>
  apa: Lieb, É., &#38; Seiringer, R. (2002). Proof of Bose-Einstein condensation for
    dilute trapped gases. <i>Physical Review Letters</i>. American Physical Society.
    <a href="https://doi.org/10.1103/PhysRevLett.88.170409">https://doi.org/10.1103/PhysRevLett.88.170409</a>
  chicago: Lieb, Élliott, and Robert Seiringer. “Proof of Bose-Einstein Condensation
    for Dilute Trapped Gases.” <i>Physical Review Letters</i>. American Physical Society,
    2002. <a href="https://doi.org/10.1103/PhysRevLett.88.170409">https://doi.org/10.1103/PhysRevLett.88.170409</a>.
  ieee: É. Lieb and R. Seiringer, “Proof of Bose-Einstein condensation for dilute
    trapped gases,” <i>Physical Review Letters</i>, vol. 88, no. 17. American Physical
    Society, pp. 1704091–1704094, 2002.
  ista: Lieb É, Seiringer R. 2002. Proof of Bose-Einstein condensation for dilute
    trapped gases. Physical Review Letters. 88(17), 1704091–1704094.
  mla: Lieb, Élliott, and Robert Seiringer. “Proof of Bose-Einstein Condensation for
    Dilute Trapped Gases.” <i>Physical Review Letters</i>, vol. 88, no. 17, American
    Physical Society, 2002, pp. 1704091–94, doi:<a href="https://doi.org/10.1103/PhysRevLett.88.170409">10.1103/PhysRevLett.88.170409</a>.
  short: É. Lieb, R. Seiringer, Physical Review Letters 88 (2002) 1704091–1704094.
date_created: 2018-12-11T11:57:08Z
date_published: 2002-04-29T00:00:00Z
date_updated: 2021-01-12T06:56:56Z
day: '29'
doi: 10.1103/PhysRevLett.88.170409
extern: 1
intvolume: '        88'
issue: '17'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math-ph/0112032
month: '04'
oa: 1
page: 1704091 - 1704094
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '4577'
quality_controlled: 0
status: public
title: Proof of Bose-Einstein condensation for dilute trapped gases
type: journal_article
volume: 88
year: '2002'
...
---
_id: '2350'
abstract:
- lang: eng
  text: Using the Pauli-Fierz model of non-relativistic quantum electrodynamics, we
    calculate the binding energy of an electron in the field of a nucleus of charge
    Z and in presence of the quantized radiation field. We consider the case of small
    coupling constant α, but fixed Zα and ultraviolet cut-off Λ. We prove that after
    renormalizing the mass the binding energy has, to leading order in α, a finite
    limit as Λ goes to infinity; i.e., the cut-off can be removed. The expression
    for the ground state energy shift thus obtained agrees with Bethe's formula for
    small values of Zα, but shows a different behavior for bigger values.
acknowledgement: "We are grateful to Elliott Lieb for helpful discussions. C.H. was
  supported by a Marie Curie Fellowship of the European Community programme “Improving
  Human Research Potential and the Socioeconomic Knowledge Base” under contract number
  HPMFCT-2000-00660 and by the Deutsche Forschungsgemeinschaft, and acknowledges kind
  hospitality at Princeton University, where part of this work was done. R.S. was
  supported by the Austrian Science Fund in the form of an Erwin Schrödinger Fellowship.\r\n"
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Christian
  full_name: Hainzl, Christian
  last_name: Hainzl
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Hainzl C, Seiringer R. Mass renormalization and energy level shift in non-relativistic
    QED. <i>Advances in Theoretical and Mathematical Physics</i>. 2002;6(5):847-871.
    doi:<a href="https://doi.org/10.4310/ATMP.2002.v6.n5.a3">10.4310/ATMP.2002.v6.n5.a3</a>
  apa: Hainzl, C., &#38; Seiringer, R. (2002). Mass renormalization and energy level
    shift in non-relativistic QED. <i>Advances in Theoretical and Mathematical Physics</i>.
    International Press. <a href="https://doi.org/10.4310/ATMP.2002.v6.n5.a3">https://doi.org/10.4310/ATMP.2002.v6.n5.a3</a>
  chicago: Hainzl, Christian, and Robert Seiringer. “Mass Renormalization and Energy
    Level Shift in Non-Relativistic QED.” <i>Advances in Theoretical and Mathematical
    Physics</i>. International Press, 2002. <a href="https://doi.org/10.4310/ATMP.2002.v6.n5.a3">https://doi.org/10.4310/ATMP.2002.v6.n5.a3</a>.
  ieee: C. Hainzl and R. Seiringer, “Mass renormalization and energy level shift in
    non-relativistic QED,” <i>Advances in Theoretical and Mathematical Physics</i>,
    vol. 6, no. 5. International Press, pp. 847–871, 2002.
  ista: Hainzl C, Seiringer R. 2002. Mass renormalization and energy level shift in
    non-relativistic QED. Advances in Theoretical and Mathematical Physics. 6(5),
    847–871.
  mla: Hainzl, Christian, and Robert Seiringer. “Mass Renormalization and Energy Level
    Shift in Non-Relativistic QED.” <i>Advances in Theoretical and Mathematical Physics</i>,
    vol. 6, no. 5, International Press, 2002, pp. 847–71, doi:<a href="https://doi.org/10.4310/ATMP.2002.v6.n5.a3">10.4310/ATMP.2002.v6.n5.a3</a>.
  short: C. Hainzl, R. Seiringer, Advances in Theoretical and Mathematical Physics
    6 (2002) 847–871.
date_created: 2018-12-11T11:57:09Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2023-07-26T08:29:28Z
day: '01'
doi: 10.4310/ATMP.2002.v6.n5.a3
extern: '1'
external_id:
  arxiv:
  - math-ph/0205044v3
intvolume: '         6'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math-ph/0205044
month: '09'
oa: 1
oa_version: Published Version
page: 847 - 871
publication: Advances in Theoretical and Mathematical Physics
publication_identifier:
  issn:
  - 1095-0761
publication_status: published
publisher: International Press
publist_id: '4574'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mass renormalization and energy level shift in non-relativistic QED
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '2002'
...
---
_id: '2351'
abstract:
- lang: eng
  text: We study the Gross-Pitaevskii functional for a rotating two-dimensional Bose
    gas in a trap. We prove that there is a breaking of the rotational symmetry in
    the ground state; more precisely, for any value of the angular velocity and for
    large enough values of the interaction strength, the ground state of the functional
    is not an eigenfunction of the angular momentum. This has interesting consequences
    on the Bose gas with spin; in particular, the ground state energy depends non-trivially
    on the number of spin components, and the different components do not have the
    same wave function. For the special case of a harmonic trap potential, we give
    explicit upper and lower bounds on the critical coupling constant for symmetry
    breaking.
author:
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Seiringer R. Gross-Pitaevskii theory of the rotating Bose gas. <i>Communications
    in Mathematical Physics</i>. 2002;229(3):491-509. doi:<a href="https://doi.org/10.1007/s00220-002-0695-2">10.1007/s00220-002-0695-2</a>
  apa: Seiringer, R. (2002). Gross-Pitaevskii theory of the rotating Bose gas. <i>Communications
    in Mathematical Physics</i>. Springer. <a href="https://doi.org/10.1007/s00220-002-0695-2">https://doi.org/10.1007/s00220-002-0695-2</a>
  chicago: Seiringer, Robert. “Gross-Pitaevskii Theory of the Rotating Bose Gas.”
    <i>Communications in Mathematical Physics</i>. Springer, 2002. <a href="https://doi.org/10.1007/s00220-002-0695-2">https://doi.org/10.1007/s00220-002-0695-2</a>.
  ieee: R. Seiringer, “Gross-Pitaevskii theory of the rotating Bose gas,” <i>Communications
    in Mathematical Physics</i>, vol. 229, no. 3. Springer, pp. 491–509, 2002.
  ista: Seiringer R. 2002. Gross-Pitaevskii theory of the rotating Bose gas. Communications
    in Mathematical Physics. 229(3), 491–509.
  mla: Seiringer, Robert. “Gross-Pitaevskii Theory of the Rotating Bose Gas.” <i>Communications
    in Mathematical Physics</i>, vol. 229, no. 3, Springer, 2002, pp. 491–509, doi:<a
    href="https://doi.org/10.1007/s00220-002-0695-2">10.1007/s00220-002-0695-2</a>.
  short: R. Seiringer, Communications in Mathematical Physics 229 (2002) 491–509.
date_created: 2018-12-11T11:57:09Z
date_published: 2002-09-01T00:00:00Z
date_updated: 2021-01-12T06:56:57Z
day: '01'
doi: 10.1007/s00220-002-0695-2
extern: 1
intvolume: '       229'
issue: '3'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math-ph/0110010
month: '09'
oa: 1
page: 491 - 509
publication: Communications in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4575'
quality_controlled: 0
status: public
title: Gross-Pitaevskii theory of the rotating Bose gas
type: journal_article
volume: 229
year: '2002'
...
---
_id: '2352'
abstract:
- lang: eng
  text: We present a generalization of the Fefferman-de la Llave decomposition of
    the Coulomb potential to quite arbitrary radial functions V on ℝn going to zero
    at infinity. This generalized decomposition can be used to extend previous results
    on N-body quantum systems with Coulomb interaction to a more general class of
    interactions. As an example of such an application, we derive the high density
    asymptotics of the ground state energy of jellium with Yukawa interaction in the
    thermodynamic limit, using a correlation estimate by Graf and Solovej.
author:
- first_name: Christian
  full_name: Hainzl, Christian
  last_name: Hainzl
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Hainzl C, Seiringer R. General decomposition of radial functions on ℝn and
    applications to N-body quantum systems. <i>Letters in Mathematical Physics</i>.
    2002;61(1):75-84. doi:<a href="https://doi.org/10.1023/A:1020204818938">10.1023/A:1020204818938</a>
  apa: Hainzl, C., &#38; Seiringer, R. (2002). General decomposition of radial functions
    on ℝn and applications to N-body quantum systems. <i>Letters in Mathematical Physics</i>.
    Springer. <a href="https://doi.org/10.1023/A:1020204818938">https://doi.org/10.1023/A:1020204818938</a>
  chicago: Hainzl, Christian, and Robert Seiringer. “General Decomposition of Radial
    Functions on ℝn and Applications to N-Body Quantum Systems.” <i>Letters in Mathematical
    Physics</i>. Springer, 2002. <a href="https://doi.org/10.1023/A:1020204818938">https://doi.org/10.1023/A:1020204818938</a>.
  ieee: C. Hainzl and R. Seiringer, “General decomposition of radial functions on
    ℝn and applications to N-body quantum systems,” <i>Letters in Mathematical Physics</i>,
    vol. 61, no. 1. Springer, pp. 75–84, 2002.
  ista: Hainzl C, Seiringer R. 2002. General decomposition of radial functions on
    ℝn and applications to N-body quantum systems. Letters in Mathematical Physics.
    61(1), 75–84.
  mla: Hainzl, Christian, and Robert Seiringer. “General Decomposition of Radial Functions
    on ℝn and Applications to N-Body Quantum Systems.” <i>Letters in Mathematical
    Physics</i>, vol. 61, no. 1, Springer, 2002, pp. 75–84, doi:<a href="https://doi.org/10.1023/A:1020204818938">10.1023/A:1020204818938</a>.
  short: C. Hainzl, R. Seiringer, Letters in Mathematical Physics 61 (2002) 75–84.
date_created: 2018-12-11T11:57:09Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2021-01-12T06:56:58Z
day: '01'
doi: 10.1023/A:1020204818938
extern: 1
intvolume: '        61'
issue: '1'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math-ph/0107011
month: '07'
oa: 1
page: 75 - 84
publication: Letters in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4576'
quality_controlled: 0
status: public
title: General decomposition of radial functions on ℝn and applications to N-body
  quantum systems
type: journal_article
volume: 61
year: '2002'
...
---
_id: '2353'
abstract:
- lang: eng
  text: A commonly used theoretical definition of superfluidity in the ground state
    of a Bose gas is based on the response of the system to an imposed velocity field
    or, equivalently, to twisted boundary conditions in a box. We are able to carry
    out this program in the case of a dilute interacting Bose gas in a trap, and we
    prove that a gas with repulsive interactions is 100% superfluid in the dilute
    limit in which the Gross-Pitaevskii equation is exact. This is the first example
    in an experimentally realistic continuum model in which superfluidity is rigorously
    verified.
acknowledgement: E.H.L. was partially supported by the U.S. National Science Foundation,
  Grant No. PHY 98-20650. R.S. was supported by the Austrian Science Fund in the from
  of an Erwin Schrödinger fellowship.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Élliott
  full_name: Lieb, Élliott
  last_name: Lieb
- first_name: Robert
  full_name: Seiringer, Robert
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
- first_name: Jakob
  full_name: Yngvason, Jakob
  last_name: Yngvason
citation:
  ama: Lieb É, Seiringer R, Yngvason J. Superfluidity in dilute trapped Bose gases.
    <i>Physical Review B - Condensed Matter and Materials Physics</i>. 2002;66(13).
    doi:<a href="https://doi.org/10.1103/PhysRevB.66.134529">10.1103/PhysRevB.66.134529</a>
  apa: Lieb, É., Seiringer, R., &#38; Yngvason, J. (2002). Superfluidity in dilute
    trapped Bose gases. <i>Physical Review B - Condensed Matter and Materials Physics</i>.
    American Physical Society. <a href="https://doi.org/10.1103/PhysRevB.66.134529">https://doi.org/10.1103/PhysRevB.66.134529</a>
  chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Superfluidity in
    Dilute Trapped Bose Gases.” <i>Physical Review B - Condensed Matter and Materials
    Physics</i>. American Physical Society, 2002. <a href="https://doi.org/10.1103/PhysRevB.66.134529">https://doi.org/10.1103/PhysRevB.66.134529</a>.
  ieee: É. Lieb, R. Seiringer, and J. Yngvason, “Superfluidity in dilute trapped Bose
    gases,” <i>Physical Review B - Condensed Matter and Materials Physics</i>, vol.
    66, no. 13. American Physical Society, 2002.
  ista: Lieb É, Seiringer R, Yngvason J. 2002. Superfluidity in dilute trapped Bose
    gases. Physical Review B - Condensed Matter and Materials Physics. 66(13).
  mla: Lieb, Élliott, et al. “Superfluidity in Dilute Trapped Bose Gases.” <i>Physical
    Review B - Condensed Matter and Materials Physics</i>, vol. 66, no. 13, American
    Physical Society, 2002, doi:<a href="https://doi.org/10.1103/PhysRevB.66.134529">10.1103/PhysRevB.66.134529</a>.
  short: É. Lieb, R. Seiringer, J. Yngvason, Physical Review B - Condensed Matter
    and Materials Physics 66 (2002).
date_created: 2018-12-11T11:57:10Z
date_published: 2002-10-01T00:00:00Z
date_updated: 2023-07-25T12:05:47Z
day: '01'
doi: 10.1103/PhysRevB.66.134529
extern: '1'
external_id:
  arxiv:
  - cond-mat/0205570
intvolume: '        66'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/cond-mat/0205570
month: '10'
oa: 1
oa_version: None
publication: Physical Review B - Condensed Matter and Materials Physics
publication_identifier:
  issn:
  - 0163-1829
publication_status: published
publisher: American Physical Society
publist_id: '4573'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superfluidity in dilute trapped Bose gases
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 66
year: '2002'
...
---
_id: '2614'
abstract:
- lang: eng
  text: Metabotropic glutamate receptors (mGluRs) from group III reduce glutamate
    release. Because these receptors reduce cAMP levels, we explored whether this
    signaling pathway contributes to release inhibition caused by mGluRs with low
    affinity for L-2-amino-4-phosphonobutyrate (L-AP4). In biochemical experiments
    with the population of cerebrocortical nerve terminals we find that L-AP4 (1 mM)
    inhibited the Ca2+dependent-evoked release of glutamate by 25%. This inhibitory
    effect was largely prevented by the pertussis toxin but was insensitive to inhibitors
    of protein kinase C bisindolylmaleimide and protein kinase A H-89. Furthermore,
    this inhibition was associated with reduction in N-type Ca2+ channel activity
    in the absence of any detectable change in cAMP levels. In the presence of forskolin,
    however, L-AP4 decreased the levels of cAMP. The activation of this additional
    signaling pathway was very efficient in counteracting the facilitation of glutamate
    release induced either by forskolin or the β-adrenergic receptor agonist isoproterenol.
    Imaging experiments to measure Ca2+ dynamics in single nerve terminals showed
    that L-AP4 strongly reduced the Ca2+ response in 28% of the nerve terminals. Moreover,
    immunochemical experiments showed that 25-35% of the nerve terminals that were
    immunopositive to synaptophysin were also immunoreactive to the low affinity L-AP4-sensitive
    mGluR7. Then, mGluR7 mediates the inhibition of glutamate release caused by 1
    mM L-AP4, primarily by a strong inhibition of Ca2+ channels, although high cAMP
    uncovers the receptor ability to decrease cAMP.
acknowledgement: We thank Dr. Enrique Castro from Las Palmas University for critical
  reading of the manuscript and M. Sefton for editorial assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Carmelo
  full_name: Millán, Carmelo
  last_name: Millán
- first_name: Rafael
  full_name: Luján, Rafael
  last_name: Luján
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: José
  full_name: Sánchez Prieto, José
  last_name: Sánchez Prieto
citation:
  ama: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. The inhibition of glutamate
    release by metabotropic glutamate receptor 7 affects both [Ca2+]c and cAMP. Evidence
    for a strong reduction of Ca2+ entry in single nerve terminals. <i>Journal of
    Biological Chemistry</i>. 2002;277(16):14092-14101. doi:<a href="https://doi.org/10.1074/jbc.M109044200">10.1074/jbc.M109044200</a>
  apa: Millán, C., Luján, R., Shigemoto, R., &#38; Sánchez Prieto, J. (2002). The
    inhibition of glutamate release by metabotropic glutamate receptor 7 affects both
    [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve
    terminals. <i>Journal of Biological Chemistry</i>. American Society for Biochemistry
    and Molecular Biology. <a href="https://doi.org/10.1074/jbc.M109044200">https://doi.org/10.1074/jbc.M109044200</a>
  chicago: Millán, Carmelo, Rafael Luján, Ryuichi Shigemoto, and José Sánchez Prieto.
    “The Inhibition of Glutamate Release by Metabotropic Glutamate Receptor 7 Affects
    Both [Ca2+]c and CAMP. Evidence for a Strong Reduction of Ca2+ Entry in Single
    Nerve Terminals.” <i>Journal of Biological Chemistry</i>. American Society for
    Biochemistry and Molecular Biology, 2002. <a href="https://doi.org/10.1074/jbc.M109044200">https://doi.org/10.1074/jbc.M109044200</a>.
  ieee: C. Millán, R. Luján, R. Shigemoto, and J. Sánchez Prieto, “The inhibition
    of glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c
    and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals,”
    <i>Journal of Biological Chemistry</i>, vol. 277, no. 16. American Society for
    Biochemistry and Molecular Biology, pp. 14092–14101, 2002.
  ista: Millán C, Luján R, Shigemoto R, Sánchez Prieto J. 2002. The inhibition of
    glutamate release by metabotropic glutamate receptor 7 affects both [Ca2+]c and
    cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve terminals.
    Journal of Biological Chemistry. 277(16), 14092–14101.
  mla: Millán, Carmelo, et al. “The Inhibition of Glutamate Release by Metabotropic
    Glutamate Receptor 7 Affects Both [Ca2+]c and CAMP. Evidence for a Strong Reduction
    of Ca2+ Entry in Single Nerve Terminals.” <i>Journal of Biological Chemistry</i>,
    vol. 277, no. 16, American Society for Biochemistry and Molecular Biology, 2002,
    pp. 14092–101, doi:<a href="https://doi.org/10.1074/jbc.M109044200">10.1074/jbc.M109044200</a>.
  short: C. Millán, R. Luján, R. Shigemoto, J. Sánchez Prieto, Journal of Biological
    Chemistry 277 (2002) 14092–14101.
date_created: 2018-12-11T11:58:41Z
date_published: 2002-04-19T00:00:00Z
date_updated: 2023-07-25T10:16:44Z
day: '19'
ddc:
- '570'
doi: 10.1074/jbc.M109044200
extern: '1'
external_id:
  pmid:
  - '11825890'
file:
- access_level: open_access
  checksum: 0290fcbbd9153ec654185b0c856f214c
  content_type: application/pdf
  creator: alisjak
  date_created: 2023-07-25T10:13:16Z
  date_updated: 2023-07-25T10:13:16Z
  file_id: '13309'
  file_name: 2002_JBC_Millan.pdf
  file_size: 2105520
  relation: main_file
  success: 1
file_date_updated: 2023-07-25T10:13:16Z
has_accepted_license: '1'
intvolume: '       277'
issue: '16'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 14092 - 14101
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
  issn:
  - 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4284'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The inhibition of glutamate release by metabotropic glutamate receptor 7 affects
  both [Ca2+]c and cAMP. Evidence for a strong reduction of Ca2+ entry in single nerve
  terminals
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 277
year: '2002'
...
---
_id: '2617'
abstract:
- lang: eng
  text: Synapses exhibit different short-term plasticity patterns and this behaviour
    influences information processing in neuronal networks. We tested how the short-term
    plasticity of excitatory postsynaptic currents (EPSCs) depends on the postsynaptic
    cell type, identified by axonal arborizations and molecular markers in the hippocampal
    CA1 area. Three distinct types of short-term synaptic behaviour (facilitating,
    depressing and combined facilitating-depressing) were defined by fitting a dynamic
    neurotransmission model to the data. Approximately 75 % of the oriens-lacunosum-moleculare
    (O-LM) interneurones received facilitating EPSCs, but in three of 12 O-LM cells
    EPSCs also showed significant depression. Over 90 % of the O-LM cells were immunopositive
    for somatostatin and mGluR1α and all tested cells were decorated by strongly mGluR7a
    positive axon terminals. Responses in eight of 12 basket cells were described
    well with a model involving only depression, but the other cells displayed combined
    facilitating-depressing EPSCs. No apparent difference was found between the plasticity
    of EPSCs in cholecystokinin- or parvalbumin-containing basket cells. In oriens-bistratified
    cells (O-Bi), two of nine cells showed facilitating EPSCs, another two depressing,
    and the remaining five cells combined facilitating-depressing EPSCs. Seven of
    10 cells tested for somatostatin were immunopositive, but mGluR1α was detectable
    only in two of 11 tested cells. Furthermore, most O-Bi cells projected to the
    CA3 area and the subiculum, as well as outside the hippocampal formation. Postsynaptic
    responses to action potentials recorded in vivo from a CA1 place cell were modelled,
    and revealed great differences between and within cell types. Our results demonstrate
    that the short-term plasticity of EPSCs is cell type dependent, but with significant
    heterogeneity within all three interneurone populations.
author:
- first_name: Attila
  full_name: Losonczy, Attila
  last_name: Losonczy
- first_name: Limei
  full_name: Zhang, Limei
  last_name: Zhang
- first_name: Ryuichi
  full_name: Ryuichi Shigemoto
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Péter
  full_name: Somogyi, Péter
  last_name: Somogyi
- first_name: Zoltán
  full_name: Nusser, Zoltán
  last_name: Nusser
citation:
  ama: Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. Cell type dependence
    and variability in the short-term plasticity of EPSCs in identified mouse hippocampal
    interneurones. <i>Journal of Physiology</i>. 2002;542(1):193-210. doi:<a href="https://doi.org/10.1113/jphysiol.2002.020024">10.1113/jphysiol.2002.020024</a>
  apa: Losonczy, A., Zhang, L., Shigemoto, R., Somogyi, P., &#38; Nusser, Z. (2002).
    Cell type dependence and variability in the short-term plasticity of EPSCs in
    identified mouse hippocampal interneurones. <i>Journal of Physiology</i>. Wiley-Blackwell.
    <a href="https://doi.org/10.1113/jphysiol.2002.020024">https://doi.org/10.1113/jphysiol.2002.020024</a>
  chicago: Losonczy, Attila, Limei Zhang, Ryuichi Shigemoto, Péter Somogyi, and Zoltán
    Nusser. “Cell Type Dependence and Variability in the Short-Term Plasticity of
    EPSCs in Identified Mouse Hippocampal Interneurones.” <i>Journal of Physiology</i>.
    Wiley-Blackwell, 2002. <a href="https://doi.org/10.1113/jphysiol.2002.020024">https://doi.org/10.1113/jphysiol.2002.020024</a>.
  ieee: A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, and Z. Nusser, “Cell type
    dependence and variability in the short-term plasticity of EPSCs in identified
    mouse hippocampal interneurones,” <i>Journal of Physiology</i>, vol. 542, no.
    1. Wiley-Blackwell, pp. 193–210, 2002.
  ista: Losonczy A, Zhang L, Shigemoto R, Somogyi P, Nusser Z. 2002. Cell type dependence
    and variability in the short-term plasticity of EPSCs in identified mouse hippocampal
    interneurones. Journal of Physiology. 542(1), 193–210.
  mla: Losonczy, Attila, et al. “Cell Type Dependence and Variability in the Short-Term
    Plasticity of EPSCs in Identified Mouse Hippocampal Interneurones.” <i>Journal
    of Physiology</i>, vol. 542, no. 1, Wiley-Blackwell, 2002, pp. 193–210, doi:<a
    href="https://doi.org/10.1113/jphysiol.2002.020024">10.1113/jphysiol.2002.020024</a>.
  short: A. Losonczy, L. Zhang, R. Shigemoto, P. Somogyi, Z. Nusser, Journal of Physiology
    542 (2002) 193–210.
date_created: 2018-12-11T11:58:42Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2021-01-12T06:58:36Z
day: '01'
doi: 10.1113/jphysiol.2002.020024
extern: 1
intvolume: '       542'
issue: '1'
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290398/
month: '07'
oa: 1
page: 193 - 210
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4281'
quality_controlled: 0
status: public
title: Cell type dependence and variability in the short-term plasticity of EPSCs
  in identified mouse hippocampal interneurones
type: journal_article
volume: 542
year: '2002'
...
---
_id: '2866'
abstract:
- lang: eng
  text: 'Developmental responses to the plant hormone auxin are thought to be mediated
    by interacting pairs from two protein families: short-lived inhibitory IAA proteins
    and ARF transcription factors binding to auxin-response elements. Monopteros mutants
    lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail to initiate
    the root meristem during early embryogenesis. Here we show that the bodenlos phenotype
    results from an amino-acid exchange in the conserved degradation domain of IAA12.
    BODENLOS and MONOPTEROS interact in the yeast two-hybrid assay and the two genes
    are coexpressed in early embryogenesis, suggesting that BODENLOS inhibits MONOPTEROS
    action in root meristem initiation.'
acknowledgement: "We thank C. Maulbetsch for isolating BDL cDNA clones; T. Berleth
  and J. Friml for providing clones for in situ probes; K. Harter for making available
  the parsley protoplast system; and J. Friml, N. Geldner, M. Griffith, C. Schwechheimer,
  D. Weigel, and D. Weijers for helpful comments and critical reading of the manuscript.
  This work was supported by Sonderforschungsbereich 446 “Mechanismen des Zellverhaltens
  bei Eukaryoten.”\r\n\r\nThe publication costs of this article were defrayed in part
  by payment of page charges. This article must therefore be hereby marked “advertisement”
  in accordance with 18 USC section 1734 solely to indicate this fact."
article_processing_charge: No
article_type: original
author:
- first_name: Thorsten
  full_name: Hamann, Thorsten
  last_name: Hamann
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Isabel
  full_name: Bäurle, Isabel
  last_name: Bäurle
- first_name: Marika
  full_name: Kientz, Marika
  last_name: Kientz
- first_name: Gerd
  full_name: Jürgens, Gerd
  last_name: Jürgens
citation:
  ama: Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. The Arabidopsis BODENLOS
    gene encodes an auxin response protein inhibiting MONOPTEROS-mediated embryo patterning.
    <i>Genes and Development</i>. 2002;16(13):1610-1615. doi:<a href="https://doi.org/10.1101/gad.229402">10.1101/gad.229402</a>
  apa: Hamann, T., Benková, E., Bäurle, I., Kientz, M., &#38; Jürgens, G. (2002).
    The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
    embryo patterning. <i>Genes and Development</i>. Cold Spring Harbor Laboratory
    Press. <a href="https://doi.org/10.1101/gad.229402">https://doi.org/10.1101/gad.229402</a>
  chicago: Hamann, Thorsten, Eva Benková, Isabel Bäurle, Marika Kientz, and Gerd Jürgens.
    “The Arabidopsis BODENLOS Gene Encodes an Auxin Response Protein Inhibiting MONOPTEROS-Mediated
    Embryo Patterning.” <i>Genes and Development</i>. Cold Spring Harbor Laboratory
    Press, 2002. <a href="https://doi.org/10.1101/gad.229402">https://doi.org/10.1101/gad.229402</a>.
  ieee: T. Hamann, E. Benková, I. Bäurle, M. Kientz, and G. Jürgens, “The Arabidopsis
    BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
    embryo patterning,” <i>Genes and Development</i>, vol. 16, no. 13. Cold Spring
    Harbor Laboratory Press, pp. 1610–1615, 2002.
  ista: Hamann T, Benková E, Bäurle I, Kientz M, Jürgens G. 2002. The Arabidopsis
    BODENLOS gene encodes an auxin response protein inhibiting MONOPTEROS-mediated
    embryo patterning. Genes and Development. 16(13), 1610–1615.
  mla: Hamann, Thorsten, et al. “The Arabidopsis BODENLOS Gene Encodes an Auxin Response
    Protein Inhibiting MONOPTEROS-Mediated Embryo Patterning.” <i>Genes and Development</i>,
    vol. 16, no. 13, Cold Spring Harbor Laboratory Press, 2002, pp. 1610–15, doi:<a
    href="https://doi.org/10.1101/gad.229402">10.1101/gad.229402</a>.
  short: T. Hamann, E. Benková, I. Bäurle, M. Kientz, G. Jürgens, Genes and Development
    16 (2002) 1610–1615.
date_created: 2018-12-11T12:00:01Z
date_published: 2002-07-01T00:00:00Z
date_updated: 2023-07-18T08:26:58Z
day: '01'
doi: 10.1101/gad.229402
extern: '1'
external_id:
  pmid:
  - '12101120'
intvolume: '        16'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC186366/
month: '07'
oa: 1
oa_version: Published Version
page: 1610 - 1615
pmid: 1
publication: Genes and Development
publication_identifier:
  issn:
  - 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '3921'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Arabidopsis BODENLOS gene encodes an auxin response protein inhibiting
  MONOPTEROS-mediated embryo patterning
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 16
year: '2002'
...
---
_id: '2987'
abstract:
- lang: eng
  text: The hydra mutants of Arabidopsis are characterized by a pleiotropic phenotype
    that shows defective embryonic and seedling cell patterning, morphogenesis, and
    root growth. We demonstrate that the HYDRA1 gene encodes a Δ8-Δ7 sterol isomerase,
    whereas HYDRA2 encodes a sterol C14 reductase, previously identified as the FACKEL
    gene product. Seedlings mutant for each gene are similarly defective in the concentrations
    of the three major Arabidopsis sterols. Promoter::reporter gene analysis showed
    misexpression of the auxin-regulated DR5 and ACS1 promoters and of the epidermal
    cell file-specific GL2 promoter in the mutants. The mutants exhibit enhanced responses
    to auxin. The phenotypes can be rescued partially by inhibition of auxin and ethylene
    signaling but not by exogenous sterols or brassinosteroids. We propose a model
    in which correct sterol profiles are required for regulated auxin and ethylene
    signaling through effects on membrane function.
acknowledgement: We thank Dr. Ken Feldmann for providing prospective hyd alleles,
  Dr. Jane Murfett for providing DR5::GUS seed, Dr. D. Van Der Straeten for providing
  ACS1::GUS seed, Dr. John Schiefelbein for providing GL2::GFP seed, and Dr. Ottoline
  Leyser for axr1-12 and axr3-1 seed. etr1 and fk seed was obtained from the Nottingham
  Arabidopsis Stock Centre. This work was supported by a Biotechnology and Biological
  Science Research Council research studentship to M.S., a Durham University studentship
  to M.P., and Biotechnology and Biological Science Research Council Grant 12/P02330
  to J.T.
article_processing_charge: No
article_type: original
author:
- first_name: Martin
  full_name: Souter, Martin
  last_name: Souter
- first_name: Jennifer
  full_name: Topping, Jennifer
  last_name: Topping
- first_name: Margaret
  full_name: Pullen, Margaret
  last_name: Pullen
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Klaus
  full_name: Palme, Klaus
  last_name: Palme
- first_name: Rachel
  full_name: Hackett, Rachel
  last_name: Hackett
- first_name: Don
  full_name: Grierson, Don
  last_name: Grierson
- first_name: Keith
  full_name: Lindsey, Keith
  last_name: Lindsey
citation:
  ama: Souter M, Topping J, Pullen M, et al. Hydra mutants of Arabidopsis are defective
    in sterol profiles and auxin and ethylene signaling. <i>Plant Cell</i>. 2002;14(5):1017-1031.
    doi:<a href="https://doi.org/10.1105/tpc.001248">10.1105/tpc.001248</a>
  apa: Souter, M., Topping, J., Pullen, M., Friml, J., Palme, K., Hackett, R., … Lindsey,
    K. (2002). Hydra mutants of Arabidopsis are defective in sterol profiles and auxin
    and ethylene signaling. <i>Plant Cell</i>. American Society of Plant Biologists.
    <a href="https://doi.org/10.1105/tpc.001248">https://doi.org/10.1105/tpc.001248</a>
  chicago: Souter, Martin, Jennifer Topping, Margaret Pullen, Jiří Friml, Klaus Palme,
    Rachel Hackett, Don Grierson, and Keith Lindsey. “Hydra Mutants of Arabidopsis
    Are Defective in Sterol Profiles and Auxin and Ethylene Signaling.” <i>Plant Cell</i>.
    American Society of Plant Biologists, 2002. <a href="https://doi.org/10.1105/tpc.001248">https://doi.org/10.1105/tpc.001248</a>.
  ieee: M. Souter <i>et al.</i>, “Hydra mutants of Arabidopsis are defective in sterol
    profiles and auxin and ethylene signaling,” <i>Plant Cell</i>, vol. 14, no. 5.
    American Society of Plant Biologists, pp. 1017–1031, 2002.
  ista: Souter M, Topping J, Pullen M, Friml J, Palme K, Hackett R, Grierson D, Lindsey
    K. 2002. Hydra mutants of Arabidopsis are defective in sterol profiles and auxin
    and ethylene signaling. Plant Cell. 14(5), 1017–1031.
  mla: Souter, Martin, et al. “Hydra Mutants of Arabidopsis Are Defective in Sterol
    Profiles and Auxin and Ethylene Signaling.” <i>Plant Cell</i>, vol. 14, no. 5,
    American Society of Plant Biologists, 2002, pp. 1017–31, doi:<a href="https://doi.org/10.1105/tpc.001248">10.1105/tpc.001248</a>.
  short: M. Souter, J. Topping, M. Pullen, J. Friml, K. Palme, R. Hackett, D. Grierson,
    K. Lindsey, Plant Cell 14 (2002) 1017–1031.
date_created: 2018-12-11T12:00:42Z
date_published: 2002-05-01T00:00:00Z
date_updated: 2023-07-18T07:34:32Z
day: '01'
doi: 10.1105/tpc.001248
extern: '1'
external_id:
  pmid:
  - '12034894'
intvolume: '        14'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC150604/
month: '05'
oa: 1
oa_version: None
page: 1017 - 1031
pmid: 1
publication: Plant Cell
publication_identifier:
  issn:
  - 1040-4651
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '3716'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Hydra mutants of Arabidopsis are defective in sterol profiles and auxin and
  ethylene signaling
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 14
year: '2002'
...
---
_id: '11124'
abstract:
- lang: eng
  text: Ran GTPase plays important roles in nucleocytoplasmic transport in interphase
    [1, 2] and in both spindle formation and nuclear envelope (NE) assembly during
    mitosis [3, 4, 5]. The latter functions rely on the presence of high local concentrations
    of GTP-bound Ran near mitotic chromatin [3, 4, 5]. RanGTP localization has been
    proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1,
    with chromatin [6, 7, 8, 9], but Ran is shown here to bind directly to chromatin
    in two modes, either dependent or independent of RCC1, and, where bound, to increase
    the affinity of chromatin for NE membranes. We propose that the Ran binding capacity
    of chromatin contributes to localized spindle and NE assembly.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Daniel
  full_name: Bilbao-Cortés, Daniel
  last_name: Bilbao-Cortés
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
- first_name: Gernot
  full_name: Längst, Gernot
  last_name: Längst
- first_name: Peter B.
  full_name: Becker, Peter B.
  last_name: Becker
- first_name: Iain W.
  full_name: Mattaj, Iain W.
  last_name: Mattaj
citation:
  ama: Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin
    by two distinct mechanisms. <i>Current Biology</i>. 2002;12(13):1151-1156. doi:<a
    href="https://doi.org/10.1016/s0960-9822(02)00927-2">10.1016/s0960-9822(02)00927-2</a>
  apa: Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P. B., &#38; Mattaj, I.
    W. (2002). Ran binds to chromatin by two distinct mechanisms. <i>Current Biology</i>.
    Elsevier BV. <a href="https://doi.org/10.1016/s0960-9822(02)00927-2">https://doi.org/10.1016/s0960-9822(02)00927-2</a>
  chicago: Bilbao-Cortés, Daniel, Martin Hetzer, Gernot Längst, Peter B. Becker, and
    Iain W. Mattaj. “Ran Binds to Chromatin by Two Distinct Mechanisms.” <i>Current
    Biology</i>. Elsevier BV, 2002. <a href="https://doi.org/10.1016/s0960-9822(02)00927-2">https://doi.org/10.1016/s0960-9822(02)00927-2</a>.
  ieee: D. Bilbao-Cortés, M. Hetzer, G. Längst, P. B. Becker, and I. W. Mattaj, “Ran
    binds to chromatin by two distinct mechanisms,” <i>Current Biology</i>, vol. 12,
    no. 13. Elsevier BV, pp. 1151–1156, 2002.
  ista: Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. 2002. Ran binds
    to chromatin by two distinct mechanisms. Current Biology. 12(13), 1151–1156.
  mla: Bilbao-Cortés, Daniel, et al. “Ran Binds to Chromatin by Two Distinct Mechanisms.”
    <i>Current Biology</i>, vol. 12, no. 13, Elsevier BV, 2002, pp. 1151–56, doi:<a
    href="https://doi.org/10.1016/s0960-9822(02)00927-2">10.1016/s0960-9822(02)00927-2</a>.
  short: D. Bilbao-Cortés, M. Hetzer, G. Längst, P.B. Becker, I.W. Mattaj, Current
    Biology 12 (2002) 1151–1156.
date_created: 2022-04-07T07:57:31Z
date_published: 2002-07-09T00:00:00Z
date_updated: 2022-07-18T08:58:05Z
day: '09'
doi: 10.1016/s0960-9822(02)00927-2
extern: '1'
external_id:
  pmid:
  - '12121625'
intvolume: '        12'
issue: '13'
keyword:
- General Agricultural and Biological Sciences
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/S0960-9822(02)00927-2
month: '07'
oa: 1
oa_version: Published Version
page: 1151-1156
pmid: 1
publication: Current Biology
publication_identifier:
  issn:
  - 0960-9822
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ran binds to chromatin by two distinct mechanisms
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 12
year: '2002'
...
---
_id: '874'
abstract:
- lang: eng
  text: Sex is thought to facilitate accumulation of initially rare beneficial mutations
    by allowing simultaneous allele replacements at many loci. However, this advantage
    of sex depends on a restrictive assumption that the fitness of a genotype is determined
    by fitness potential, a single intermediate variable to which all loci contribute
    additively, so that new alleles can accumulate in any order. Individual-based
    simulations of sexual and asexual populations reveal that under generic selection,
    sex often retards adaptive evolution. When new alleles are beneficial only if
    they accumulate in a prescribed order, a sexual population may evolve two or more
    times slower than an asexual population because only asexual reproduction allows
    some overlap of successive allele replacements. Many other fitness surfaces lead
    to an even greater disadvantage of sex. Thus, either sex exists in spite of its
    impact on the rate of adaptive allele replacements, or natural fitness surfaces
    have rather specific properties, at least at the scale of intrapopulation genetic
    variability.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Alexey
  full_name: Kondrashov, Alexey
  last_name: Kondrashov
citation:
  ama: Kondrashov F, Kondrashov A. Multidimensional epistasis and the disadvantage
    of sex. <i>PNAS</i>. 2001;98(21):12089-12092. doi:<a href="https://doi.org/10.1073/pnas.211214298">10.1073/pnas.211214298</a>
  apa: Kondrashov, F., &#38; Kondrashov, A. (2001). Multidimensional epistasis and
    the disadvantage of sex. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.211214298">https://doi.org/10.1073/pnas.211214298</a>
  chicago: Kondrashov, Fyodor, and Alexey Kondrashov. “Multidimensional Epistasis
    and the Disadvantage of Sex.” <i>PNAS</i>. National Academy of Sciences, 2001.
    <a href="https://doi.org/10.1073/pnas.211214298">https://doi.org/10.1073/pnas.211214298</a>.
  ieee: F. Kondrashov and A. Kondrashov, “Multidimensional epistasis and the disadvantage
    of sex,” <i>PNAS</i>, vol. 98, no. 21. National Academy of Sciences, pp. 12089–12092,
    2001.
  ista: Kondrashov F, Kondrashov A. 2001. Multidimensional epistasis and the disadvantage
    of sex. PNAS. 98(21), 12089–12092.
  mla: Kondrashov, Fyodor, and Alexey Kondrashov. “Multidimensional Epistasis and
    the Disadvantage of Sex.” <i>PNAS</i>, vol. 98, no. 21, National Academy of Sciences,
    2001, pp. 12089–92, doi:<a href="https://doi.org/10.1073/pnas.211214298">10.1073/pnas.211214298</a>.
  short: F. Kondrashov, A. Kondrashov, PNAS 98 (2001) 12089–12092.
date_created: 2018-12-11T11:48:58Z
date_published: 2001-10-09T00:00:00Z
date_updated: 2023-06-02T08:18:22Z
day: '09'
doi: 10.1073/pnas.211214298
extern: '1'
external_id:
  pmid:
  - '11593020'
intvolume: '        98'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC59772/
month: '10'
oa: 1
oa_version: Published Version
page: 12089 - 12092
pmid: 1
publication: PNAS
publication_identifier:
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '6774'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multidimensional epistasis and the disadvantage of sex
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 98
year: '2001'
...
---
_id: '888'
abstract:
- lang: eng
  text: 'BACKGROUND: Detection of changes in a protein''s evolutionary rate may reveal
    cases of change in that protein''s function. We developed and implemented a simple
    relative rates test in an attempt to assess the rate constancy of protein evolution
    and to detect cases of functional diversification between orthologous proteins.
    The test was performed on clusters of orthologous protein sequences from complete
    bacterial genomes (Chlamydia trachomatis, C. muridarum and Chlamydophila pneumoniae),
    complete archaeal genomes (Pyrococcus horikoshii, P. abyssi and P. furiosus) and
    partially sequenced mammalian genomes (human, mouse and rat). RESULTS: Amino-acid
    sequence evolution rates are significantly correlated on different branches of
    phylogenetic trees representing the great majority of analyzed orthologous protein
    sets from all three domains of life. However, approximately 1% of the proteins
    from each group of species deviates from this pattern and instead shows variation
    that is consistent with an acceleration of the rate of amino-acid substitution,
    which may be due to functional diversification. Most of the putative functionally
    diversified proteins from all three species groups are predicted to function at
    the periphery of the cells and mediate their interaction with the environment.
    CONCLUSIONS: Relative rates of protein evolution are remarkably constant for the
    three species groups analyzed here. Deviations from this rate constancy are probably
    due to changes in selective constraints associated with diversification between
    orthologs. Functional diversification between orthologs is thought to be a relatively
    rare event. However, the resolution afforded by the test designed specifically
    for genomic-scale datasets allowed us to identify numerous cases of possible functional
    diversification between orthologous proteins.'
acknowledgement: We thank Alexey Kondrashov for many helpful discussions and constructive
  criticisms, Charles DeLisi, David Landsman, Detlef Leipe, Wojciech Makalowski and
  Itai Yanai for critical reading of the manuscript and constructive comments and
  L. Aravind for advice on protein function prediction. The release of the unpublished
  P. furiosus genome sequence by the Utah Genome Center at the University of Utah
  is acknowledged and appreciated.
article_number: research0053.1
article_processing_charge: No
article_type: original
author:
- first_name: Ingo
  full_name: Jordan, Ingo
  last_name: Jordan
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Igor
  full_name: Rogozin, Igor
  last_name: Rogozin
- first_name: Roman
  full_name: Tatusov, Roman
  last_name: Tatusov
- first_name: Yuri
  full_name: Wolf, Yuri
  last_name: Wolf
- first_name: Eugene
  full_name: Koonin, Eugene
  last_name: Koonin
citation:
  ama: Jordan I, Kondrashov F, Rogozin I, Tatusov R, Wolf Y, Koonin E. Constant relative
    rate of protein evolution and detection of functional diversification among bacterial,
    archaeal and eukaryotic proteins . <i>Genome Biology</i>. 2001;2(12). doi:<a href="https://doi.org/10.1186/gb-2001-2-12-research0053">10.1186/gb-2001-2-12-research0053</a>
  apa: Jordan, I., Kondrashov, F., Rogozin, I., Tatusov, R., Wolf, Y., &#38; Koonin,
    E. (2001). Constant relative rate of protein evolution and detection of functional
    diversification among bacterial, archaeal and eukaryotic proteins . <i>Genome
    Biology</i>. BioMed Central. <a href="https://doi.org/10.1186/gb-2001-2-12-research0053">https://doi.org/10.1186/gb-2001-2-12-research0053</a>
  chicago: Jordan, Ingo, Fyodor Kondrashov, Igor Rogozin, Roman Tatusov, Yuri Wolf,
    and Eugene Koonin. “Constant Relative Rate of Protein Evolution and Detection
    of Functional Diversification among Bacterial, Archaeal and Eukaryotic Proteins
    .” <i>Genome Biology</i>. BioMed Central, 2001. <a href="https://doi.org/10.1186/gb-2001-2-12-research0053">https://doi.org/10.1186/gb-2001-2-12-research0053</a>.
  ieee: I. Jordan, F. Kondrashov, I. Rogozin, R. Tatusov, Y. Wolf, and E. Koonin,
    “Constant relative rate of protein evolution and detection of functional diversification
    among bacterial, archaeal and eukaryotic proteins ,” <i>Genome Biology</i>, vol.
    2, no. 12. BioMed Central, 2001.
  ista: Jordan I, Kondrashov F, Rogozin I, Tatusov R, Wolf Y, Koonin E. 2001. Constant
    relative rate of protein evolution and detection of functional diversification
    among bacterial, archaeal and eukaryotic proteins . Genome Biology. 2(12), research0053.1.
  mla: Jordan, Ingo, et al. “Constant Relative Rate of Protein Evolution and Detection
    of Functional Diversification among Bacterial, Archaeal and Eukaryotic Proteins
    .” <i>Genome Biology</i>, vol. 2, no. 12, research0053.1, BioMed Central, 2001,
    doi:<a href="https://doi.org/10.1186/gb-2001-2-12-research0053">10.1186/gb-2001-2-12-research0053</a>.
  short: I. Jordan, F. Kondrashov, I. Rogozin, R. Tatusov, Y. Wolf, E. Koonin, Genome
    Biology 2 (2001).
date_created: 2018-12-11T11:49:02Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-31T12:15:37Z
day: '01'
doi: 10.1186/gb-2001-2-12-research0053
extern: '1'
external_id:
  pmid:
  - '11790256'
intvolume: '         2'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC64838/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genome Biology
publication_identifier:
  issn:
  - 1465-6906
publication_status: published
publisher: BioMed Central
publist_id: '6758'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Constant relative rate of protein evolution and detection of functional diversification
  among bacterial, archaeal and eukaryotic proteins '
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 2
year: '2001'
...
---
_id: '1452'
abstract:
- lang: eng
  text: 'In this Note we present pairs of hyperkähler orbifolds which satisfy two
    different versions of mirror symmetry. On the one hand, we show that their Hodge
    numbers (or more precisely, stringy E-polynomials) are equal. On the other hand,
    we show that they satisfy the prescription of Strominger, Yau, and Zaslow (which
    in the present case goes back to Bershadsky, Johansen, Sadov and Vafa): that a
    Calabi-Yau and its mirror should fiber over the same real manifold, with special
    Lagrangian fibers which are tori dual to each other. Our examples arise as moduli
    spaces of local systems on a curve with structure group SL(n); the mirror is the
    corresponding space with structure group PGL(n). The special Lagrangian tori come
    from an algebraically completely integrable Hamiltonian system: the Hitchin system.'
acknowledgement: The authors are grateful for Nigel Hitchin for suggesting the similarity
  between [4] and [12] in 1996 and for Pierre Deligne for numerous useful comments
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tamas
  full_name: Hausel, Tamas
  id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
  last_name: Hausel
- first_name: Michael
  full_name: Thaddeus, Michael
  last_name: Thaddeus
citation:
  ama: 'Hausel T, Thaddeus M. Examples of mirror partners arising from integrable
    systems. <i>Comptes Rendus de l’Academie des Sciences - Series I: Mathematics</i>.
    2001;333(4):313-318. doi:<a href="https://doi.org/10.1016/S0764-4442(01)02057-2">10.1016/S0764-4442(01)02057-2</a>'
  apa: 'Hausel, T., &#38; Thaddeus, M. (2001). Examples of mirror partners arising
    from integrable systems. <i>Comptes Rendus de l’Academie Des Sciences - Series
    I: Mathematics</i>. Elsevier. <a href="https://doi.org/10.1016/S0764-4442(01)02057-2">https://doi.org/10.1016/S0764-4442(01)02057-2</a>'
  chicago: 'Hausel, Tamás, and Michael Thaddeus. “Examples of Mirror Partners Arising
    from Integrable Systems.” <i>Comptes Rendus de l’Academie Des Sciences - Series
    I: Mathematics</i>. Elsevier, 2001. <a href="https://doi.org/10.1016/S0764-4442(01)02057-2">https://doi.org/10.1016/S0764-4442(01)02057-2</a>.'
  ieee: 'T. Hausel and M. Thaddeus, “Examples of mirror partners arising from integrable
    systems,” <i>Comptes Rendus de l’Academie des Sciences - Series I: Mathematics</i>,
    vol. 333, no. 4. Elsevier, pp. 313–318, 2001.'
  ista: 'Hausel T, Thaddeus M. 2001. Examples of mirror partners arising from integrable
    systems. Comptes Rendus de l’Academie des Sciences - Series I: Mathematics. 333(4),
    313–318.'
  mla: 'Hausel, Tamás, and Michael Thaddeus. “Examples of Mirror Partners Arising
    from Integrable Systems.” <i>Comptes Rendus de l’Academie Des Sciences - Series
    I: Mathematics</i>, vol. 333, no. 4, Elsevier, 2001, pp. 313–18, doi:<a href="https://doi.org/10.1016/S0764-4442(01)02057-2">10.1016/S0764-4442(01)02057-2</a>.'
  short: 'T. Hausel, M. Thaddeus, Comptes Rendus de l’Academie Des Sciences - Series
    I: Mathematics 333 (2001) 313–318.'
date_created: 2018-12-11T11:52:06Z
date_published: 2001-08-15T00:00:00Z
date_updated: 2023-05-31T09:57:48Z
day: '15'
doi: 10.1016/S0764-4442(01)02057-2
extern: '1'
external_id:
  arxiv:
  - math/0106140
intvolume: '       333'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/math/0106140
month: '08'
oa: 1
oa_version: Preprint
page: 313 - 318
publication: 'Comptes Rendus de l''Academie des Sciences - Series I: Mathematics'
publication_identifier:
  issn:
  - 0764-4442
publication_status: published
publisher: Elsevier
publist_id: '5742'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Examples of mirror partners arising from integrable systems
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 333
year: '2001'
...
---
_id: '1453'
abstract:
- lang: eng
  text: In this Letter we exhibit a one-parameter family of new Taub-NUT instantons
    parameterized by a half-line. The endpoint of the half-line will be the reducible
    Yang-Mills instanton corresponding to the Eguchi-Hanson-Gibbons L2 harmonic 2-form,
    while at an inner point we recover the Pope-Yuille instanton constructed as a
    projection of the Levi-Civitá connection onto the positive su(2)+ ⊂ so(4) subalgebra.
    Our method imitates the Jackiw-Nohl-Rebbi construction originally designed for
    flat R4. That is we find a one-parameter family of harmonic functions on the Taub-NUT
    space with a point singularity, rescale the metric and project the obtained Levi-Civitá
    connection onto the other negative su(2)- ⊂ so(4) part. Our solutions will possess
    the full U(2) symmetry, and thus provide more solutions to the recently proposed
    U(2) symmetric ansatz of Kim and Yoon.
acknowledgement: We would like to acknowledge the financial support provided by the
  Miller Institute of Basic Research in Science, the Japan Society for the Promotion
  of Science, grant No. P99736 and the partial support by OTKA grant No. T032478.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Gábor
  full_name: Etesi, Gábor
  last_name: Etesi
- first_name: Tamas
  full_name: Hausel, Tamas
  id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
  last_name: Hausel
citation:
  ama: 'Etesi G, Hausel T. Geometric construction of new Yang-Mills instantons over
    Taub-NUT space. <i>Physics Letters, Section B: Nuclear, Elementary Particle and
    High-Energy Physics</i>. 2001;514(1-2):189-199. doi:<a href="https://doi.org/10.1016/S0370-2693(01)00821-8">10.1016/S0370-2693(01)00821-8</a>'
  apa: 'Etesi, G., &#38; Hausel, T. (2001). Geometric construction of new Yang-Mills
    instantons over Taub-NUT space. <i>Physics Letters, Section B: Nuclear, Elementary
    Particle and High-Energy Physics</i>. Elsevier. <a href="https://doi.org/10.1016/S0370-2693(01)00821-8">https://doi.org/10.1016/S0370-2693(01)00821-8</a>'
  chicago: 'Etesi, Gábor, and Tamás Hausel. “Geometric Construction of New Yang-Mills
    Instantons over Taub-NUT Space.” <i>Physics Letters, Section B: Nuclear, Elementary
    Particle and High-Energy Physics</i>. Elsevier, 2001. <a href="https://doi.org/10.1016/S0370-2693(01)00821-8">https://doi.org/10.1016/S0370-2693(01)00821-8</a>.'
  ieee: 'G. Etesi and T. Hausel, “Geometric construction of new Yang-Mills instantons
    over Taub-NUT space,” <i>Physics Letters, Section B: Nuclear, Elementary Particle
    and High-Energy Physics</i>, vol. 514, no. 1–2. Elsevier, pp. 189–199, 2001.'
  ista: 'Etesi G, Hausel T. 2001. Geometric construction of new Yang-Mills instantons
    over Taub-NUT space. Physics Letters, Section B: Nuclear, Elementary Particle
    and High-Energy Physics. 514(1–2), 189–199.'
  mla: 'Etesi, Gábor, and Tamás Hausel. “Geometric Construction of New Yang-Mills
    Instantons over Taub-NUT Space.” <i>Physics Letters, Section B: Nuclear, Elementary
    Particle and High-Energy Physics</i>, vol. 514, no. 1–2, Elsevier, 2001, pp. 189–99,
    doi:<a href="https://doi.org/10.1016/S0370-2693(01)00821-8">10.1016/S0370-2693(01)00821-8</a>.'
  short: 'G. Etesi, T. Hausel, Physics Letters, Section B: Nuclear, Elementary Particle
    and High-Energy Physics 514 (2001) 189–199.'
date_created: 2018-12-11T11:52:07Z
date_published: 2001-08-09T00:00:00Z
date_updated: 2023-05-31T11:51:37Z
day: '09'
doi: 10.1016/S0370-2693(01)00821-8
extern: '1'
external_id:
  arxiv:
  - hep-th/0105118
intvolume: '       514'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/hep-th/0105118
month: '08'
oa: 1
oa_version: Preprint
page: 189 - 199
publication: 'Physics Letters, Section B: Nuclear, Elementary Particle and High-Energy
  Physics'
publication_identifier:
  issn:
  - 0370-2693
publication_status: published
publisher: Elsevier
publist_id: '5743'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometric construction of new Yang-Mills instantons over Taub-NUT space
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 514
year: '2001'
...
---
_id: '1454'
abstract:
- lang: eng
  text: We address the problem of finding Abelian instantons of finite energy on the
    Euclidean Schwarzschild manifold. This amounts to construct self-dual L2 harmonic
    2-forms on the space. Gibbons found a non-topological L2 harmonic form in the
    Taub-NUT metric, leading to Abelian instantons with continuous energy. We imitate
    his construction in the case of the Euclidean Schwarzschild manifold and find
    a non-topological self-dual L2 harmonic 2-form on it. We show how this gives rise
    to Abelian instantons and identify them with SU(2)-instantons of Pontryagin number
    2n2 found by Charap and Duff in 1977. Using results of Dodziuk and Hitchin we
    also calculate the full L2 harmonic space for the Euclidean Schwarzschild manifold.
acknowledgement: The work in this paper was done when Tamás Hausel visited the Yukawa
  Institute of Kyoto University in February 2000. We are grateful for Prof. G.W. Gibbons
  for insightful discussions and Prof. H. Kodama and the Yukawa Institute for the
  invitation and hospitality.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Gábor
  full_name: Etesi, Gábor
  last_name: Etesi
- first_name: Tamas
  full_name: Hausel, Tamas
  id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
  last_name: Hausel
citation:
  ama: Etesi G, Hausel T. Geometric interpretation of Schwarzschild instantons. <i>Journal
    of Geometry and Physics</i>. 2001;37(1-2):126-136. doi:<a href="https://doi.org/10.1016/S0393-0440(00)00040-1">10.1016/S0393-0440(00)00040-1</a>
  apa: Etesi, G., &#38; Hausel, T. (2001). Geometric interpretation of Schwarzschild
    instantons. <i>Journal of Geometry and Physics</i>. Elsevier. <a href="https://doi.org/10.1016/S0393-0440(00)00040-1">https://doi.org/10.1016/S0393-0440(00)00040-1</a>
  chicago: Etesi, Gábor, and Tamás Hausel. “Geometric Interpretation of Schwarzschild
    Instantons.” <i>Journal of Geometry and Physics</i>. Elsevier, 2001. <a href="https://doi.org/10.1016/S0393-0440(00)00040-1">https://doi.org/10.1016/S0393-0440(00)00040-1</a>.
  ieee: G. Etesi and T. Hausel, “Geometric interpretation of Schwarzschild instantons,”
    <i>Journal of Geometry and Physics</i>, vol. 37, no. 1–2. Elsevier, pp. 126–136,
    2001.
  ista: Etesi G, Hausel T. 2001. Geometric interpretation of Schwarzschild instantons.
    Journal of Geometry and Physics. 37(1–2), 126–136.
  mla: Etesi, Gábor, and Tamás Hausel. “Geometric Interpretation of Schwarzschild
    Instantons.” <i>Journal of Geometry and Physics</i>, vol. 37, no. 1–2, Elsevier,
    2001, pp. 126–36, doi:<a href="https://doi.org/10.1016/S0393-0440(00)00040-1">10.1016/S0393-0440(00)00040-1</a>.
  short: G. Etesi, T. Hausel, Journal of Geometry and Physics 37 (2001) 126–136.
date_created: 2018-12-11T11:52:07Z
date_published: 2001-01-01T00:00:00Z
date_updated: 2023-05-31T12:08:45Z
day: '01'
doi: 10.1016/S0393-0440(00)00040-1
extern: '1'
external_id:
  arxiv:
  - hep-th/0003239
intvolume: '        37'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/hep-th/0003239
month: '01'
oa: 1
oa_version: Preprint
page: 126 - 136
publication: Journal of Geometry and Physics
publication_identifier:
  issn:
  - 0393-0440
publication_status: published
publisher: Elsevier
publist_id: '5744'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Geometric interpretation of Schwarzschild instantons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 37
year: '2001'
...
