---
_id: '3992'
abstract:
- lang: eng
text: Computing the volume occupied by individual atoms in macromolecular structures
has been the subject of research for several decades. This interest has grown
in the recent years, because weighted volumes are widely used in implicit solvent
models. Applications of the latter in molecular mechanics simulations require
that the derivatives of these weighted volumes be known. In this article, we give
a formula for the volume derivative of a molecule modeled as a space-filling diagram
made up of balls in motion. The formula is given in terms of the weights, radii,
and distances between the centers as well as the sizes of the facets of the power
diagram restricted to the space-filling diagram. Special attention is given to
the detection and treatment of singularities as well as discontinuities of the
derivative.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Patrice
full_name: Koehl, Patrice
last_name: Koehl
citation:
ama: Edelsbrunner H, Koehl P. The weighted-volume derivative of a space-filling
diagram. PNAS. 2003;100(5):2203-2208. doi:10.1073/pnas.0537830100
apa: Edelsbrunner, H., & Koehl, P. (2003). The weighted-volume derivative of
a space-filling diagram. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.0537830100
chicago: Edelsbrunner, Herbert, and Patrice Koehl. “The Weighted-Volume Derivative
of a Space-Filling Diagram.” PNAS. National Academy of Sciences, 2003.
https://doi.org/10.1073/pnas.0537830100.
ieee: H. Edelsbrunner and P. Koehl, “The weighted-volume derivative of a space-filling
diagram,” PNAS, vol. 100, no. 5. National Academy of Sciences, pp. 2203–2208,
2003.
ista: Edelsbrunner H, Koehl P. 2003. The weighted-volume derivative of a space-filling
diagram. PNAS. 100(5), 2203–2208.
mla: Edelsbrunner, Herbert, and Patrice Koehl. “The Weighted-Volume Derivative of
a Space-Filling Diagram.” PNAS, vol. 100, no. 5, National Academy of Sciences,
2003, pp. 2203–08, doi:10.1073/pnas.0537830100.
short: H. Edelsbrunner, P. Koehl, PNAS 100 (2003) 2203–2208.
date_created: 2018-12-11T12:06:19Z
date_published: 2003-03-04T00:00:00Z
date_updated: 2024-02-27T12:31:59Z
day: '04'
doi: 10.1073/pnas.0537830100
extern: '1'
external_id:
pmid:
- '12601153'
intvolume: ' 100'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151318/
month: '03'
oa: 1
oa_version: Published Version
page: 2203 - 2208
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2133'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The weighted-volume derivative of a space-filling diagram
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 100
year: '2003'
...
---
_id: '4146'
abstract:
- lang: eng
text: During vertebrate gastrulation, highly coordinated cellular rearrangements
lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm.
In zebrafish, silberblick (slb)/wnt11 regulates normal gastrulation movements
by activating a signalling pathway similar to the Frizzled-signalling pathway,
which establishes epithelial planar cell polarity (PCP) in Drosophila. However,
the cellular mechanisms by which slb/wnt11 functions during zebrafish gastrulation
are still unclear. Using high-resolution two-photon confocal imaging followed
by computer-assisted reconstruction and motion analysis, we have analysed the
movement and morphology of individual cells in three dimensions during the course
of gastrulation. We show that in slb-mutant embryos, hypoblast cells within the
forming germ ring have slower, less directed migratory movements at the onset
of gastrulation. These aberrant cell movements are accompanied by defects in the
orientation of cellular processes along the individual movement directions of
these cells. We conclude that slb/wnt11-mediated orientation of cellular processes
plays a role in facilitating and stabilising movements of hypoblast cells in the
germ ring, thereby pointing at a novel function of the slb/wnt11 signalling pathway
for the regulation of migratory cell movements at early stages of gastrulation.
acknowledgement: 'We thank Jennifer Geiger, Mathias Köppen, Christian Dahmann and
Marcos Gonzalez-Gaitan for helpful comments on earlier versions of this manuscript,Beate
Kilian for technical assistance, Ugur Yalcin, Katrin Anczok and Viktor Schnabel
for help with the image analysis, Vinzenz Link for programming Excel Macros and
Harald Brush-Janovjak for extensive reviews of the statistics part of this work.
We are grateful to Kurt Anderson and Jan Peychl for help with the confocal microscopy.
P.J.H., E.V. and D.R.S. are supported by NIH grant HD-18577, The W.M Keck Foundation
and the Developmental Studies Hybridoma Bank(DSHB), P.J.H. by The American Cancer
Society (grant # PF-01-110-01-CSM),M.L.C. and S.W.W. by the Wellcome Trust, M.T.
by an MRC Career Development Award, and F.U. and C.P.H. by an Emmy-Noether-Fellowship
from the DFG.'
article_processing_charge: No
article_type: original
author:
- first_name: Florian
full_name: Ulrich, Florian
last_name: Ulrich
- first_name: Miguel
full_name: Concha, Miguel
last_name: Concha
- first_name: Paul
full_name: Heid, Paul
last_name: Heid
- first_name: Ed
full_name: Voss, Ed
last_name: Voss
- first_name: Sabine
full_name: Witzel, Sabine
last_name: Witzel
- first_name: Henry
full_name: Roehl, Henry
last_name: Roehl
- first_name: Masazumi
full_name: Tada, Masazumi
last_name: Tada
- first_name: Stephen
full_name: Wilson, Stephen
last_name: Wilson
- first_name: Richard
full_name: Adams, Richard
last_name: Adams
- first_name: David
full_name: Soll, David
last_name: Soll
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Ulrich F, Concha M, Heid P, et al. Slb/Wnt11 controls hypoblast cell migration
and morphogenesis at the onset of zebrafish gastrulation. Development.
2003;130(22):5375-5384. doi:10.1242/dev.00758
apa: Ulrich, F., Concha, M., Heid, P., Voss, E., Witzel, S., Roehl, H., … Heisenberg,
C.-P. J. (2003). Slb/Wnt11 controls hypoblast cell migration and morphogenesis
at the onset of zebrafish gastrulation. Development. Company of Biologists.
https://doi.org/10.1242/dev.00758
chicago: Ulrich, Florian, Miguel Concha, Paul Heid, Ed Voss, Sabine Witzel, Henry
Roehl, Masazumi Tada, et al. “Slb/Wnt11 Controls Hypoblast Cell Migration and
Morphogenesis at the Onset of Zebrafish Gastrulation.” Development. Company
of Biologists, 2003. https://doi.org/10.1242/dev.00758.
ieee: F. Ulrich et al., “Slb/Wnt11 controls hypoblast cell migration and
morphogenesis at the onset of zebrafish gastrulation,” Development, vol.
130, no. 22. Company of Biologists, pp. 5375–5384, 2003.
ista: Ulrich F, Concha M, Heid P, Voss E, Witzel S, Roehl H, Tada M, Wilson S, Adams
R, Soll D, Heisenberg C-PJ. 2003. Slb/Wnt11 controls hypoblast cell migration
and morphogenesis at the onset of zebrafish gastrulation. Development. 130(22),
5375–5384.
mla: Ulrich, Florian, et al. “Slb/Wnt11 Controls Hypoblast Cell Migration and Morphogenesis
at the Onset of Zebrafish Gastrulation.” Development, vol. 130, no. 22,
Company of Biologists, 2003, pp. 5375–84, doi:10.1242/dev.00758.
short: F. Ulrich, M. Concha, P. Heid, E. Voss, S. Witzel, H. Roehl, M. Tada, S.
Wilson, R. Adams, D. Soll, C.-P.J. Heisenberg, Development 130 (2003) 5375–5384.
date_created: 2018-12-11T12:07:13Z
date_published: 2003-11-15T00:00:00Z
date_updated: 2024-02-27T10:14:21Z
day: '15'
doi: 10.1242/dev.00758
extern: '1'
external_id:
pmid:
- ' PMC1414802'
intvolume: ' 130'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1414802/
month: '11'
oa: 1
oa_version: None
page: 5375 - 5384
pmid: 1
publication: Development
publication_identifier:
issn:
- 1011-6370
publication_status: published
publisher: Company of Biologists
publist_id: '1975'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Slb/Wnt11 controls hypoblast cell migration and morphogenesis at the onset
of zebrafish gastrulation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 130
year: '2003'
...
---
_id: '2337'
alternative_title:
- Contemporary Mathematics
author:
- first_name: Élliott
full_name: Lieb, Élliott H
last_name: Lieb
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: 'Lieb É, Seiringer R. Bose-Einstein condensation of dilute gases in traps .
In: Karpeshina Y, Weikard R, Zeng Y, eds. Vol 327. American Mathematical Society;
2003:239-250. doi:10.1090/conm/327/05818'
apa: Lieb, É., & Seiringer, R. (2003). Bose-Einstein condensation of dilute
gases in traps . In Y. Karpeshina, R. Weikard, & Y. Zeng (Eds.) (Vol. 327,
pp. 239–250). Presented at the Differential Equations and Mathematical Physics,
American Mathematical Society. https://doi.org/10.1090/conm/327/05818
chicago: Lieb, Élliott, and Robert Seiringer. “Bose-Einstein Condensation of Dilute
Gases in Traps .” edited by Yulia Karpeshina, Rudi Weikard, and Yanni Zeng, 327:239–50.
American Mathematical Society, 2003. https://doi.org/10.1090/conm/327/05818.
ieee: É. Lieb and R. Seiringer, “Bose-Einstein condensation of dilute gases in traps
,” presented at the Differential Equations and Mathematical Physics, 2003, vol.
327, pp. 239–250.
ista: Lieb É, Seiringer R. 2003. Bose-Einstein condensation of dilute gases in traps
. Differential Equations and Mathematical Physics, Contemporary Mathematics, vol.
327, 239–250.
mla: Lieb, Élliott, and Robert Seiringer. Bose-Einstein Condensation of Dilute
Gases in Traps . Edited by Yulia Karpeshina et al., vol. 327, American Mathematical
Society, 2003, pp. 239–50, doi:10.1090/conm/327/05818.
short: É. Lieb, R. Seiringer, in:, Y. Karpeshina, R. Weikard, Y. Zeng (Eds.), American
Mathematical Society, 2003, pp. 239–250.
conference:
name: Differential Equations and Mathematical Physics
date_created: 2018-12-11T11:57:04Z
date_published: 2003-01-01T00:00:00Z
date_updated: 2021-01-12T06:56:52Z
day: '01'
doi: 10.1090/conm/327/05818
editor:
- first_name: Yulia
full_name: Karpeshina, Yulia
last_name: Karpeshina
- first_name: Rudi
full_name: Weikard, Rudi
last_name: Weikard
- first_name: Yanni
full_name: Zeng, Yanni
last_name: Zeng
extern: 1
intvolume: ' 327'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0210028
month: '01'
oa: 1
page: 239 - 250
publication_status: published
publisher: American Mathematical Society
publist_id: '4589'
quality_controlled: 0
status: public
title: 'Bose-Einstein condensation of dilute gases in traps '
type: conference
volume: 327
year: '2003'
...
---
_id: '2354'
abstract:
- lang: eng
text: We investigate the ground state properties of a gas of interacting particles
confined in an external potential in three dimensions and subject to rotation
around an axis of symmetry. We consider the Gross-Pitaevskii (GP) limit of a dilute
gas. Analysing both the absolute and the bosonic ground states of the system,
we show, in particular, their different behaviour for a certain range of parameters.
This parameter range is determined by the question whether the rotational symmetry
in the minimizer of the GP functional is broken or not. For the absolute ground
state, we prove that in the GP limit a modified GP functional depending on density
matrices correctly describes the energy and reduced density matrices, independent
of symmetry breaking. For the bosonic ground state this holds true if and only
if the symmetry is unbroken.
author:
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: 'Seiringer R. Ground state asymptotics of a dilute, rotating gas. Journal
of Physics A: Mathematical and Theoretical. 2003;36(37):9755-9778. doi:10.1088/0305-4470/36/37/312'
apa: 'Seiringer, R. (2003). Ground state asymptotics of a dilute, rotating gas.
Journal of Physics A: Mathematical and Theoretical. IOP Publishing Ltd.
https://doi.org/10.1088/0305-4470/36/37/312'
chicago: 'Seiringer, Robert. “Ground State Asymptotics of a Dilute, Rotating Gas.”
Journal of Physics A: Mathematical and Theoretical. IOP Publishing Ltd.,
2003. https://doi.org/10.1088/0305-4470/36/37/312.'
ieee: 'R. Seiringer, “Ground state asymptotics of a dilute, rotating gas,” Journal
of Physics A: Mathematical and Theoretical, vol. 36, no. 37. IOP Publishing
Ltd., pp. 9755–9778, 2003.'
ista: 'Seiringer R. 2003. Ground state asymptotics of a dilute, rotating gas. Journal
of Physics A: Mathematical and Theoretical. 36(37), 9755–9778.'
mla: 'Seiringer, Robert. “Ground State Asymptotics of a Dilute, Rotating Gas.” Journal
of Physics A: Mathematical and Theoretical, vol. 36, no. 37, IOP Publishing
Ltd., 2003, pp. 9755–78, doi:10.1088/0305-4470/36/37/312.'
short: 'R. Seiringer, Journal of Physics A: Mathematical and Theoretical 36 (2003)
9755–9778.'
date_created: 2018-12-11T11:57:10Z
date_published: 2003-09-19T00:00:00Z
date_updated: 2021-01-12T06:56:59Z
day: '19'
doi: 10.1088/0305-4470/36/37/312
extern: 1
intvolume: ' 36'
issue: '37'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math-ph/0306022
month: '09'
oa: 1
page: 9755 - 9778
publication: 'Journal of Physics A: Mathematical and Theoretical'
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '4572'
quality_controlled: 0
status: public
title: Ground state asymptotics of a dilute, rotating gas
type: journal_article
volume: 36
year: '2003'
...
---
_id: '2357'
abstract:
- lang: eng
text: 'The classic Poincaré inequality bounds the L q-norm of a function f in a
bounded domain Ω ⊂ ℝ n in terms of some L p-norm of its gradient in Ω. We generalize
this in two ways: In the first generalization we remove a set Τ from Ω and concentrate
our attention on Λ = Ω \ Τ. This new domain might not even be connected and hence
no Poincaré inequality can generally hold for it, or if it does hold it might
have a very bad constant. This is so even if the volume of Τ is arbitrarily small.
A Poincaré inequality does hold, however, if one makes the additional assumption
that f has a finite L p gradient norm on the whole of Ω, not just on Λ. The important
point is that the Poincaré inequality thus obtained bounds the L q-norm of f in
terms of the L p gradient norm on Λ (not Ω) plus an additional term that goes
to zero as the volume of Τ goes to zero. This error term depends on Τ only through
its volume. Apart from this additive error term, the constant in the inequality
remains that of the ''nice'' domain Ω. In the second generalization we are given
a vector field A and replace ∇ by ∇ + iA(x) (geometrically, a connection on a
U(1) bundle). Unlike the A = 0 case, the infimum of ∥(∇ + iA)f∥ p over all f with
a given ∥f∥ q is in general not zero. This permits an improvement of the inequality
by the addition of a term whose sharp value we derive. We describe some open problems
that arise from these generalizations.'
author:
- first_name: Élliott
full_name: Lieb, Élliott H
last_name: Lieb
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: Lieb É, Seiringer R, Yngvason J. Poincaré inequalities in punctured domains.
Annals of Mathematics. 2003;158(3):1067-1080. doi:10.4007/annals.2003.158.1067
apa: Lieb, É., Seiringer, R., & Yngvason, J. (2003). Poincaré inequalities in
punctured domains. Annals of Mathematics. Princeton University Press. https://doi.org/10.4007/annals.2003.158.1067
chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Poincaré Inequalities
in Punctured Domains.” Annals of Mathematics. Princeton University Press,
2003. https://doi.org/10.4007/annals.2003.158.1067
.
ieee: É. Lieb, R. Seiringer, and J. Yngvason, “Poincaré inequalities in punctured
domains,” Annals of Mathematics, vol. 158, no. 3. Princeton University
Press, pp. 1067–1080, 2003.
ista: Lieb É, Seiringer R, Yngvason J. 2003. Poincaré inequalities in punctured
domains. Annals of Mathematics. 158(3), 1067–1080.
mla: Lieb, Élliott, et al. “Poincaré Inequalities in Punctured Domains.” Annals
of Mathematics, vol. 158, no. 3, Princeton University Press, 2003, pp. 1067–80,
doi:10.4007/annals.2003.158.1067
.
short: É. Lieb, R. Seiringer, J. Yngvason, Annals of Mathematics 158 (2003) 1067–1080.
date_created: 2018-12-11T11:57:11Z
date_published: 2003-11-01T00:00:00Z
date_updated: 2021-01-12T06:57:00Z
day: '01'
doi: '10.4007/annals.2003.158.1067 '
extern: 1
intvolume: ' 158'
issue: '3'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/math/0205088
month: '11'
oa: 1
page: 1067 - 1080
publication: Annals of Mathematics
publication_status: published
publisher: Princeton University Press
publist_id: '4570'
quality_controlled: 0
status: public
title: Poincaré inequalities in punctured domains
type: journal_article
volume: 158
year: '2003'
...
---
_id: '2358'
abstract:
- lang: eng
text: A study was conducted on the one-dimensional (1D) bosons in three-dimensional
(3D) traps. A rigorous analysis was carried out on the parameter regions in which
various types of 1D or 3D behavior occurred in the ground state. The four parameter
regions include density, transverse, longitudinal dimensions and scattering length.
author:
- first_name: Élliott
full_name: Lieb, Élliott H
last_name: Lieb
- first_name: Robert
full_name: Robert Seiringer
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
- first_name: Jakob
full_name: Yngvason, Jakob
last_name: Yngvason
citation:
ama: Lieb É, Seiringer R, Yngvason J. One-dimensional Bosons in three-dimensional
traps. Physical Review Letters. 2003;91(15):1504011-1504014. doi:10.1103/PhysRevLett.91.150401
apa: Lieb, É., Seiringer, R., & Yngvason, J. (2003). One-dimensional Bosons
in three-dimensional traps. Physical Review Letters. American Physical
Society. https://doi.org/10.1103/PhysRevLett.91.150401
chicago: Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “One-Dimensional Bosons
in Three-Dimensional Traps.” Physical Review Letters. American Physical
Society, 2003. https://doi.org/10.1103/PhysRevLett.91.150401.
ieee: É. Lieb, R. Seiringer, and J. Yngvason, “One-dimensional Bosons in three-dimensional
traps,” Physical Review Letters, vol. 91, no. 15. American Physical Society,
pp. 1504011–1504014, 2003.
ista: Lieb É, Seiringer R, Yngvason J. 2003. One-dimensional Bosons in three-dimensional
traps. Physical Review Letters. 91(15), 1504011–1504014.
mla: Lieb, Élliott, et al. “One-Dimensional Bosons in Three-Dimensional Traps.”
Physical Review Letters, vol. 91, no. 15, American Physical Society, 2003,
pp. 1504011–14, doi:10.1103/PhysRevLett.91.150401.
short: É. Lieb, R. Seiringer, J. Yngvason, Physical Review Letters 91 (2003) 1504011–1504014.
date_created: 2018-12-11T11:57:12Z
date_published: 2003-10-10T00:00:00Z
date_updated: 2021-01-12T06:57:00Z
day: '10'
doi: 10.1103/PhysRevLett.91.150401
extern: 1
intvolume: ' 91'
issue: '15'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/cond-mat/0304071
month: '10'
oa: 1
page: 1504011 - 1504014
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '4571'
quality_controlled: 0
status: public
title: One-dimensional Bosons in three-dimensional traps
type: journal_article
volume: 91
year: '2003'
...
---
_id: '11766'
abstract:
- lang: eng
text: 'This paper studies the multicast routing and admission control problem on
unit-capacity tree and mesh topologies in the throughput model. The problem is
a generalization of the edge-disjoint paths problem and is NP-hard both on trees
and meshes. We study both the offline and the online version of the problem: In
the offline setting, we give the first constant-factor approximation algorithm
for trees, and an -factor approximation algorithm for meshes. In the online setting,
we give the first polylogarithmic competitive online algorithm for tree and mesh
topologies. No polylogarithmic-competitive algorithm is possible on general network
topologies (Lower bounds for on-line graph problems with application to on-line
circuits and optical routing, in: Proceedings of the 28th ACM Symposium on Theory
of Computing, 1996, pp. 531–540) and there exists a polylogarithmic lower bound
on the competitive ratio of any online algorithm on tree topologies (Making commitments
in the face of uncertainity: how to pick a winner almost every time, in: Proceedings
of the 28th Annual ACM Symposium on Theory of Computing, 1996, pp. 519–530). We
prove the same lower bound for meshes.'
article_processing_charge: No
article_type: original
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Stefano
full_name: Leonardi, Stefano
last_name: Leonardi
citation:
ama: Henzinger MH, Leonardi S. Scheduling multicasts on unit-capacity trees and
meshes. Journal of Computer and System Sciences. 2003;66(3):567-611. doi:10.1016/s0022-0000(03)00043-6
apa: Henzinger, M. H., & Leonardi, S. (2003). Scheduling multicasts on unit-capacity
trees and meshes. Journal of Computer and System Sciences. Elsevier. https://doi.org/10.1016/s0022-0000(03)00043-6
chicago: Henzinger, Monika H, and Stefano Leonardi. “Scheduling Multicasts on Unit-Capacity
Trees and Meshes.” Journal of Computer and System Sciences. Elsevier, 2003.
https://doi.org/10.1016/s0022-0000(03)00043-6.
ieee: M. H. Henzinger and S. Leonardi, “Scheduling multicasts on unit-capacity trees
and meshes,” Journal of Computer and System Sciences, vol. 66, no. 3. Elsevier,
pp. 567–611, 2003.
ista: Henzinger MH, Leonardi S. 2003. Scheduling multicasts on unit-capacity trees
and meshes. Journal of Computer and System Sciences. 66(3), 567–611.
mla: Henzinger, Monika H., and Stefano Leonardi. “Scheduling Multicasts on Unit-Capacity
Trees and Meshes.” Journal of Computer and System Sciences, vol. 66, no.
3, Elsevier, 2003, pp. 567–611, doi:10.1016/s0022-0000(03)00043-6.
short: M.H. Henzinger, S. Leonardi, Journal of Computer and System Sciences 66 (2003)
567–611.
date_created: 2022-08-08T12:24:35Z
date_published: 2003-05-01T00:00:00Z
date_updated: 2023-02-10T08:03:31Z
day: '01'
doi: 10.1016/s0022-0000(03)00043-6
extern: '1'
intvolume: ' 66'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/S0022-0000(03)00043-6
month: '05'
oa: 1
oa_version: Published Version
page: 567-611
publication: Journal of Computer and System Sciences
publication_identifier:
issn:
- 0022-0000
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scheduling multicasts on unit-capacity trees and meshes
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2003'
...
---
_id: '11909'
abstract:
- lang: eng
text: This article presents a high-level discussion of some problems that are unique
to web search engines. The goal is to raise awareness and stimulate research in
these areas.
article_processing_charge: No
author:
- first_name: Monika H
full_name: Henzinger, Monika H
id: 540c9bbd-f2de-11ec-812d-d04a5be85630
last_name: Henzinger
orcid: 0000-0002-5008-6530
- first_name: Rajeev
full_name: Motwani, Rajeev
last_name: Motwani
- first_name: Craig
full_name: Silverstein, Craig
last_name: Silverstein
citation:
ama: 'Henzinger MH, Motwani R, Silverstein C. Challenges in web search engines.
In: 18th International Joint Conference on Artificial Intelligence. Association
for Computing Machinery; 2003:1573-1579.'
apa: 'Henzinger, M. H., Motwani, R., & Silverstein, C. (2003). Challenges in
web search engines. In 18th International Joint Conference on Artificial Intelligence
(pp. 1573–1579). Acapulco, Mexico: Association for Computing Machinery.'
chicago: Henzinger, Monika H, Rajeev Motwani, and Craig Silverstein. “Challenges
in Web Search Engines.” In 18th International Joint Conference on Artificial
Intelligence, 1573–79. Association for Computing Machinery, 2003.
ieee: M. H. Henzinger, R. Motwani, and C. Silverstein, “Challenges in web search
engines,” in 18th International Joint Conference on Artificial Intelligence,
Acapulco, Mexico, 2003, pp. 1573–1579.
ista: 'Henzinger MH, Motwani R, Silverstein C. 2003. Challenges in web search engines.
18th International Joint Conference on Artificial Intelligence. IJCAI: International
Joint Conference on Artificial Intelligence, 1573–1579.'
mla: Henzinger, Monika H., et al. “Challenges in Web Search Engines.” 18th International
Joint Conference on Artificial Intelligence, Association for Computing Machinery,
2003, pp. 1573–79.
short: M.H. Henzinger, R. Motwani, C. Silverstein, in:, 18th International Joint
Conference on Artificial Intelligence, Association for Computing Machinery, 2003,
pp. 1573–1579.
conference:
end_date: 2003-08-15
location: Acapulco, Mexico
name: 'IJCAI: International Joint Conference on Artificial Intelligence'
start_date: 2003-08-09
date_created: 2022-08-18T06:40:02Z
date_published: 2003-08-01T00:00:00Z
date_updated: 2023-02-09T12:05:25Z
day: '01'
extern: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ijcai.org/Proceedings/03/Papers/278.pdf
month: '08'
oa: 1
oa_version: Published Version
page: 1573-1579
publication: 18th International Joint Conference on Artificial Intelligence
publication_identifier:
issn:
- 1045-0823
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Challenges in web search engines
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2003'
...
---
_id: '12659'
abstract:
- lang: eng
text: "For many years considerable efforts have been put into investigating and
modelling hydrological processes of mountainous catchments. On the one hand, the
complexity and intrinsically high variability of the involved processes as well
as insufficient knowledge of the underlying physical mechanisms still induce large
uncertainties in understanding observed phenomena and predicting the behaviour
of the system. On the other hand, the demand for models that are able to simulate
mountainous water resource systems is increasing because of the needs related
to both water exploitation and water conservation, which clearly call for an integrated
vision and modelling of these systems.\r\nAccordingly, this paper moves from a
brief survey of the most significant achievements in mountain hydrology to discuss
what could be future challenging issues related to the broader spectrum of questions,
which hydrologic modelling of mountainous river systems may face in the next decades.
Firstly, reference is made to existing methodologies for modelling alpine water
systems, focussing on some specific aspects that provide a basis for the discussion
of the weaknesses and perspectives of present simulation tools. The future is
thus discussed, delineating some of the research challenges that may foster a
comprehensive and integrated vision of water related issues in mountainous regions."
article_processing_charge: No
article_type: original
author:
- first_name: Paolo
full_name: Burlando, Paolo
last_name: Burlando
- first_name: Francesca
full_name: Pellicciotti, Francesca
id: b28f055a-81ea-11ed-b70c-a9fe7f7b0e70
last_name: Pellicciotti
- first_name: Ulrich
full_name: Strasser, Ulrich
last_name: Strasser
citation:
ama: Burlando P, Pellicciotti F, Strasser U. Modelling mountainous water systems
between learning and speculating looking for challenges. Hydrology Research.
2002;33(1):47-74. doi:10.2166/nh.2002.0004
apa: Burlando, P., Pellicciotti, F., & Strasser, U. (2002). Modelling mountainous
water systems between learning and speculating looking for challenges. Hydrology
Research. IWA Publishing. https://doi.org/10.2166/nh.2002.0004
chicago: Burlando, Paolo, Francesca Pellicciotti, and Ulrich Strasser. “Modelling
Mountainous Water Systems between Learning and Speculating Looking for Challenges.”
Hydrology Research. IWA Publishing, 2002. https://doi.org/10.2166/nh.2002.0004.
ieee: P. Burlando, F. Pellicciotti, and U. Strasser, “Modelling mountainous water
systems between learning and speculating looking for challenges,” Hydrology
Research, vol. 33, no. 1. IWA Publishing, pp. 47–74, 2002.
ista: Burlando P, Pellicciotti F, Strasser U. 2002. Modelling mountainous water
systems between learning and speculating looking for challenges. Hydrology Research.
33(1), 47–74.
mla: Burlando, Paolo, et al. “Modelling Mountainous Water Systems between Learning
and Speculating Looking for Challenges.” Hydrology Research, vol. 33, no.
1, IWA Publishing, 2002, pp. 47–74, doi:10.2166/nh.2002.0004.
short: P. Burlando, F. Pellicciotti, U. Strasser, Hydrology Research 33 (2002) 47–74.
date_created: 2023-02-20T08:19:02Z
date_published: 2002-02-01T00:00:00Z
date_updated: 2023-02-20T08:30:15Z
day: '01'
doi: 10.2166/nh.2002.0004
extern: '1'
intvolume: ' 33'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.2166/nh.2002.0004
month: '02'
oa: 1
oa_version: Published Version
page: 47-74
publication: Hydrology Research
publication_identifier:
eissn:
- 2224-7955
issn:
- 0029-1277
publication_status: published
publisher: IWA Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Modelling mountainous water systems between learning and speculating looking
for challenges
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2002'
...
---
_id: '871'
abstract:
- lang: eng
text: 'BACKGROUND: Gene duplications have a major role in the evolution of new biological
functions. Theoretical studies often assume that a duplication per se is selectively
neutral and that, following a duplication, one of the gene copies is freed from
purifying (stabilizing) selection, which creates the potential for evolution of
a new function. RESULTS: In search of systematic evidence of accelerated evolution
after duplication, we used data from 26 bacterial, six archaeal, and seven eukaryotic
genomes to compare the mode and strength of selection acting on recently duplicated
genes (paralogs) and on similarly diverged, unduplicated orthologous genes in
different species. We find that the ratio of nonsynonymous to synonymous substitutions
(Kn/Ks) in most paralogous pairs is <<1 and that paralogs typically evolve
at similar rates, without significant asymmetry, indicating that both paralogs
produced by a duplication are subject to purifying selection. This selection is,
however, substantially weaker than the purifying selection affecting unduplicated
orthologs that have diverged to the same extent as the analyzed paralogs. Most
of the recently duplicated genes appear to be involved in various forms of environmental
response; in particular, many of them encode membrane and secreted proteins. CONCLUSIONS:
The results of this analysis indicate that recently duplicated paralogs evolve
faster than orthologs with the same level of divergence and similar functions,
but apparently do not experience a phase of neutral evolution. We hypothesize
that gene duplications that persist in an evolving lineage are beneficial from
the time of their origin, due primarily to a protein dosage effect in response
to variable environmental conditions; duplications are likely to give rise to
new functions at a later phase of their evolution once a higher level of divergence
is reached.'
acknowledgement: We are grateful to A.S. Kondrashov for numerous helpful suggestions,
to I. King Jordan, M.A. Roytberg, J.L. Spouge and D.A. Kondrashov for useful discussions
and to A.S. Kondrashov, I. King Jordan and D.J. Lipman for critical reading of the
manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Igor
full_name: Rogozin, Igor
last_name: Rogozin
- first_name: Yuri
full_name: Wolf, Yuri
last_name: Wolf
- first_name: Eugene
full_name: Koonin, Eugene
last_name: Koonin
citation:
ama: Kondrashov F, Rogozin I, Wolf Y, Koonin E. Selection in the evolution of gene
duplications . Genome Biology. 2002;3(2). doi:10.1186/gb-2002-3-2-research0008
apa: Kondrashov, F., Rogozin, I., Wolf, Y., & Koonin, E. (2002). Selection in
the evolution of gene duplications . Genome Biology. BioMed Central. https://doi.org/10.1186/gb-2002-3-2-research0008
chicago: Kondrashov, Fyodor, Igor Rogozin, Yuri Wolf, and Eugene Koonin. “Selection
in the Evolution of Gene Duplications .” Genome Biology. BioMed Central,
2002. https://doi.org/10.1186/gb-2002-3-2-research0008.
ieee: F. Kondrashov, I. Rogozin, Y. Wolf, and E. Koonin, “Selection in the evolution
of gene duplications ,” Genome Biology, vol. 3, no. 2. BioMed Central,
2002.
ista: Kondrashov F, Rogozin I, Wolf Y, Koonin E. 2002. Selection in the evolution
of gene duplications . Genome Biology. 3(2).
mla: Kondrashov, Fyodor, et al. “Selection in the Evolution of Gene Duplications
.” Genome Biology, vol. 3, no. 2, BioMed Central, 2002, doi:10.1186/gb-2002-3-2-research0008.
short: F. Kondrashov, I. Rogozin, Y. Wolf, E. Koonin, Genome Biology 3 (2002).
date_created: 2018-12-11T11:48:57Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-26T11:48:27Z
day: '01'
doi: 10.1186/gb-2002-3-2-research0008
extern: '1'
external_id:
pmid:
- '11864370'
intvolume: ' 3'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC65685/
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genome Biology
publication_identifier:
issn:
- 1465-6906
publication_status: published
publisher: BioMed Central
publist_id: '6781'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Selection in the evolution of gene duplications '
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '2002'
...
---
_id: '885'
abstract:
- lang: eng
text: We study fitness landscape in the space of protein sequences by relating sets
of human pathogenic missense mutations in 32 proteins to amino acid substitutions
that occurred in the course of evolution of these proteins. On average, ≈10% of
deviations of a nonhuman protein from its human ortholog are compensated pathogenic
deviations (CPDs), i.e., are caused by an amino acid substitution that, at this
site, would be pathogenic to humans. Normal functioning of a CPD-containing protein
must be caused by other, compensatory deviations of the nonhuman species from
humans. Together, a CPD and the corresponding compensatory deviation form a Dobzhansky-Muller
incompatibility that can be visualized as the corner on a fitness ridge. Thus,
proteins evolve along fitness ridges which contain only ≈10 steps between sucessive
corners. The fraction of CPDs among all deviations of a protein from its human
ortholog does not increase with the evolutionary distance between the proteins,
indicating that subtitutions that carry evolving proteins around these corners
occur in rapid succession, driven by positive selection. Data on fitness of interspecies
hybrids suggest that the compensatory change that makes a CPD fit usually occurs
within the same protein. Data on protein structures and on cooccurrence of amino
acids at different sites of multiple orthologous proteins often make it possible
to provisionally identify the substitution that compensates a partiCUlar CPD.
article_processing_charge: No
article_type: original
author:
- first_name: Alexey
full_name: Kondrashov, Alexey
last_name: Kondrashov
- first_name: Shamil
full_name: Sunyaev, Shamil
last_name: Sunyaev
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Kondrashov A, Sunyaev S, Kondrashov F. Dobzhansky-Muller incompatibilities
in protein evolution. PNAS. 2002;99(23):14878-14883. doi:10.1073/pnas.232565499
apa: Kondrashov, A., Sunyaev, S., & Kondrashov, F. (2002). Dobzhansky-Muller
incompatibilities in protein evolution. PNAS. National Academy of Sciences.
https://doi.org/10.1073/pnas.232565499
chicago: Kondrashov, Alexey, Shamil Sunyaev, and Fyodor Kondrashov. “Dobzhansky-Muller
Incompatibilities in Protein Evolution.” PNAS. National Academy of Sciences,
2002. https://doi.org/10.1073/pnas.232565499.
ieee: A. Kondrashov, S. Sunyaev, and F. Kondrashov, “Dobzhansky-Muller incompatibilities
in protein evolution,” PNAS, vol. 99, no. 23. National Academy of Sciences,
pp. 14878–14883, 2002.
ista: Kondrashov A, Sunyaev S, Kondrashov F. 2002. Dobzhansky-Muller incompatibilities
in protein evolution. PNAS. 99(23), 14878–14883.
mla: Kondrashov, Alexey, et al. “Dobzhansky-Muller Incompatibilities in Protein
Evolution.” PNAS, vol. 99, no. 23, National Academy of Sciences, 2002,
pp. 14878–83, doi:10.1073/pnas.232565499.
short: A. Kondrashov, S. Sunyaev, F. Kondrashov, PNAS 99 (2002) 14878–14883.
date_created: 2018-12-11T11:49:01Z
date_published: 2002-11-12T00:00:00Z
date_updated: 2023-07-26T09:48:37Z
day: '12'
doi: 10.1073/pnas.232565499
extern: '1'
external_id:
pmid:
- '12403824'
intvolume: ' 99'
issue: '23'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC137512/
month: '11'
oa: 1
oa_version: Published Version
page: 14878 - 14883
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '6763'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Dobzhansky-Muller incompatibilities in protein evolution
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 99
year: '2002'
...
---
_id: '13438'
abstract:
- lang: eng
text: ICln is an ion channel identified by expression cloning using a cDNA library
from Madin-Darby canine kidney cells. In all organisms tested so far, only one
transcript for the ICln protein could be identified. Here we show that two splice
variants of the ICln ion channel can be found in Caenorhabditis elegans. Moreover,
we show that these two splice variants of the ICln channel protein, which we termed
IClnN1 and IClnN2, can be functionally reconstituted and tested in an artificial
lipid bilayer. In these experiments, the IClnN1-induced currents showed no voltage-dependent
inactivation, whereas the IClnN2-induced currents fully inactivated at positive
potentials. The molecular entity responsible for the voltage-dependent inactivation
of IClnN2 is a cluster of positively charged amino acids encoded by exon 2a, which
is absent in IClnN1. Our experiments suggest a mechanism of channel inactivation
that is similar to the “ball and chain” model proposed for the Shaker potassium
channel,i.e. a cluster of positively charged amino acids hinders ion permeation
through the channel by a molecular and voltage-dependent interaction at the inner
vestibulum of the pore. This hypothesis is supported by the finding that synthetic
peptides with the same amino acid sequence as the positive cluster can transform
the IClnN1-induced current to the current observed after reconstitution of IClnN2.
Furthermore, we show that the nematode ICln gene is embedded in an operon harboring
two additional genes, which we termed Nx and Ny. Co-reconstitution of Nx and IClnN2
and functional analysis of the related currents revealed a functional interaction
between the two proteins, as evidenced by the fact that the IClnN2-induced current
in the presence of Nx was no longer voltage-sensitive. The experiments described
indicate that the genome organization in nematodes allows an effective approach
for the identification of functional partner proteins of ion channels.
acknowledgement: We are grateful to D. E. Clapham, E. Wöll, G. Meyer, and G. Botta
for helpful discussion and/or reading of the manuscript. We also thank T. Stiernagle
for providing the N2 strain of C. elegans and A. Wimmer and M. Frick for technical
assistance
article_processing_charge: No
article_type: original
author:
- first_name: Johannes
full_name: Fürst, Johannes
last_name: Fürst
- first_name: Markus
full_name: Ritter, Markus
last_name: Ritter
- first_name: Jakob
full_name: Rudzki, Jakob
last_name: Rudzki
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Martin
full_name: Gschwentner, Martin
last_name: Gschwentner
- first_name: Elke
full_name: Scandella, Elke
last_name: Scandella
- first_name: Martin
full_name: Jakab, Martin
last_name: Jakab
- first_name: Matthias
full_name: König, Matthias
last_name: König
- first_name: Bernhard
full_name: Oehl, Bernhard
last_name: Oehl
- first_name: Florian
full_name: Lang, Florian
last_name: Lang
- first_name: Peter
full_name: Deetjen, Peter
last_name: Deetjen
- first_name: Markus
full_name: Paulmichl, Markus
last_name: Paulmichl
citation:
ama: Fürst J, Ritter M, Rudzki J, et al. ICln Ion channel splice variants in Caenorhabditis
elegans. Journal of Biological Chemistry. 2002;277(6):4435-4445. doi:10.1074/jbc.m107372200
apa: Fürst, J., Ritter, M., Rudzki, J., Danzl, J. G., Gschwentner, M., Scandella,
E., … Paulmichl, M. (2002). ICln Ion channel splice variants in Caenorhabditis
elegans. Journal of Biological Chemistry. Elsevier. https://doi.org/10.1074/jbc.m107372200
chicago: Fürst, Johannes, Markus Ritter, Jakob Rudzki, Johann G Danzl, Martin Gschwentner,
Elke Scandella, Martin Jakab, et al. “ICln Ion Channel Splice Variants in Caenorhabditis
Elegans.” Journal of Biological Chemistry. Elsevier, 2002. https://doi.org/10.1074/jbc.m107372200.
ieee: J. Fürst et al., “ICln Ion channel splice variants in Caenorhabditis
elegans,” Journal of Biological Chemistry, vol. 277, no. 6. Elsevier, pp.
4435–4445, 2002.
ista: Fürst J, Ritter M, Rudzki J, Danzl JG, Gschwentner M, Scandella E, Jakab M,
König M, Oehl B, Lang F, Deetjen P, Paulmichl M. 2002. ICln Ion channel splice
variants in Caenorhabditis elegans. Journal of Biological Chemistry. 277(6), 4435–4445.
mla: Fürst, Johannes, et al. “ICln Ion Channel Splice Variants in Caenorhabditis
Elegans.” Journal of Biological Chemistry, vol. 277, no. 6, Elsevier, 2002,
pp. 4435–45, doi:10.1074/jbc.m107372200.
short: J. Fürst, M. Ritter, J. Rudzki, J.G. Danzl, M. Gschwentner, E. Scandella,
M. Jakab, M. König, B. Oehl, F. Lang, P. Deetjen, M. Paulmichl, Journal of Biological
Chemistry 277 (2002) 4435–4445.
date_created: 2023-08-01T12:37:50Z
date_published: 2002-02-08T00:00:00Z
date_updated: 2023-08-01T12:55:54Z
day: '08'
ddc:
- '570'
doi: 10.1074/jbc.m107372200
extern: '1'
external_id:
pmid:
- '11706026'
file:
- access_level: open_access
checksum: 13abe20f78eb37ab62beb006f62c69b7
content_type: application/pdf
creator: alisjak
date_created: 2023-08-01T12:44:09Z
date_updated: 2023-08-01T12:44:09Z
file_id: '13439'
file_name: 2002_JBC_Fuerst.pdf
file_size: 798920
relation: main_file
success: 1
file_date_updated: 2023-08-01T12:44:09Z
has_accepted_license: '1'
intvolume: ' 277'
issue: '6'
keyword:
- Cell Biology
- Molecular Biology
- Biochemistry
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 4435-4445
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: ICln Ion channel splice variants in Caenorhabditis elegans
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 277
year: '2002'
...
---
_id: '1451'
abstract:
- lang: eng
text: Extending work of Bielawski-Dancer 3 and Konno 14, we develop a theory of
toric hyperkähler varieties, which involves toric geometry, matroid theory and
convex polyhedra. The framework is a detailed study of semi-projective toric varieties,
meaning GIT quotients of affine spaces by torus actions, and specifically, of
Lawrence toric varieties, meaning GIT quotients of even-dimensional affine spaces
by symplectic torus actions. A toric hyperkähler variety is a complete intersection
in a Lawrence toric variety. Both varieties are non-compact, and they share the
same cohomology ring, namely, the Stanley-Reisner ring of a matroid modulo a linear
system of parameters. Familiar applications of toric geometry to combinatorics,
including the Hard Lefschetz Theorem and the volume polynomials of Khovanskii-Pukhlikov
11, are extended to the hyperkähler setting. When the matroid is graphic, our
construction gives the toric quiver varieties, in the sense of Nakajima 17.
acknowledgement: "Both authors were supported by the Miller Institute for Basic Research
in Science, in the form of a Miller Research Fellowship (1999-2002) for the first
author and a Miller Professorship (2000-2001) for the second author. The second
author was also supported by the National Science\r\nFoundation (DMS-9970254)."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Tamas
full_name: Hausel, Tamas
id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
last_name: Hausel
- first_name: Bernd
full_name: Sturmfels, Bernd
last_name: Sturmfels
citation:
ama: Hausel T, Sturmfels B. Toric hyperkähler varieties. Documenta Mathematica.
2002;7(1):495-534. doi:10.4171/DM/130
apa: Hausel, T., & Sturmfels, B. (2002). Toric hyperkähler varieties. Documenta
Mathematica. Deutsche Mathematiker Vereinigung. https://doi.org/10.4171/DM/130
chicago: Hausel, Tamás, and Bernd Sturmfels. “Toric Hyperkähler Varieties.” Documenta
Mathematica. Deutsche Mathematiker Vereinigung, 2002. https://doi.org/10.4171/DM/130.
ieee: T. Hausel and B. Sturmfels, “Toric hyperkähler varieties,” Documenta Mathematica,
vol. 7, no. 1. Deutsche Mathematiker Vereinigung, pp. 495–534, 2002.
ista: Hausel T, Sturmfels B. 2002. Toric hyperkähler varieties. Documenta Mathematica.
7(1), 495–534.
mla: Hausel, Tamás, and Bernd Sturmfels. “Toric Hyperkähler Varieties.” Documenta
Mathematica, vol. 7, no. 1, Deutsche Mathematiker Vereinigung, 2002, pp. 495–534,
doi:10.4171/DM/130.
short: T. Hausel, B. Sturmfels, Documenta Mathematica 7 (2002) 495–534.
date_created: 2018-12-11T11:52:06Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-26T09:16:33Z
day: '01'
doi: 10.4171/DM/130
extern: '1'
external_id:
arxiv:
- math/0203096
intvolume: ' 7'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://ems.press/journals/dm/articles/8965058
month: '01'
oa: 1
oa_version: Published Version
page: 495 - 534
publication: Documenta Mathematica
publication_identifier:
issn:
- 1431-0635
publication_status: published
publisher: Deutsche Mathematiker Vereinigung
publist_id: '5741'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Toric hyperkähler varieties
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 7
year: '2002'
...
---
_id: '3508'
abstract:
- lang: eng
text: A method of automatic conversion of a physical object into a three-dimensional
digital model. The method acquires a set of measured data points on the surface
of a physical model. From the measured data points, the method reconstructs a
digital model of the physical object using a Delaunay complex of the points, a
flow strcuture of the simplicies in the Delaunay complex and retracting the Delaunay
complex into a digital model of the physical object using the flow structure.
The method then outputs the digital model of the physical object.
applicant:
- Raindrop Geomagic, Inc.
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Ping
full_name: Fu, Ping
last_name: Fu
citation:
ama: Edelsbrunner H, Fu P. Methods of generating three-dimensional digital models
of objects by wrapping point cloud data points. 2002.
apa: Edelsbrunner, H., & Fu, P. (2002). Methods of generating three-dimensional
digital models of objects by wrapping point cloud data points.
chicago: Edelsbrunner, Herbert, and Ping Fu. “Methods of Generating Three-Dimensional
Digital Models of Objects by Wrapping Point Cloud Data Points,” 2002.
ieee: H. Edelsbrunner and P. Fu, “Methods of generating three-dimensional digital
models of objects by wrapping point cloud data points.” 2002.
ista: Edelsbrunner H, Fu P. 2002. Methods of generating three-dimensional digital
models of objects by wrapping point cloud data points.
mla: Edelsbrunner, Herbert, and Ping Fu. Methods of Generating Three-Dimensional
Digital Models of Objects by Wrapping Point Cloud Data Points. 2002.
short: H. Edelsbrunner, P. Fu, (2002).
date_created: 2018-12-11T12:03:42Z
date_published: 2002-04-23T00:00:00Z
date_updated: 2022-01-05T14:09:36Z
day: '23'
extern: '1'
ipc: G16Z99/00 ; G06K9/28 ; G06T17/10 ; G06T17/20
ipn: US6377865B1
main_file_link:
- open_access: '1'
url: https://patents.google.com/patent/US6377865B1
month: '04'
oa: 1
oa_version: Published Version
publication_date: 2002-04-23
publist_id: '2879'
status: public
title: Methods of generating three-dimensional digital models of objects by wrapping
point cloud data points
type: patent
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2002'
...
---
_id: '3621'
abstract:
- lang: eng
text: In 1991, Barton and Turelli developed recursions to describe the evolution
of multilocus systems under arbitrary forms of selection. This article generalizes
their approach to allow for arbitrary modes of inheritance, including diploidy,
polyploidy, sex linkage, cytoplasmic inheritance, and genomic imprinting. The
framework is also extended to allow for other deterministic evolutionary forces,
including migration and mutation. Exact recursions that fully describe the state
of the population are presented; these are implemented in a computer algebra package
(available on the Web at http://helios.bto.ed.ac.uk/evolgen). Despite the generality
of our framework, it can describe evolutionary dynamics exactly by just two equations.
These recursions can be further simplified using a "quasi-linkage equilibrium"
(QLE) approximation. We illustrate the methods by finding the effect of natural
selection, sexual selection, mutation, and migration on the genetic composition
of a population.
article_processing_charge: No
article_type: original
author:
- first_name: Mark
full_name: Kirkpatrick, Mark
last_name: Kirkpatrick
- first_name: Toby
full_name: Johnson, Toby
last_name: Johnson
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Kirkpatrick M, Johnson T, Barton NH. General models of multilocus evolution.
Genetics. 2002;161(4):1727-1750. doi:10.1093/genetics/161.4.1727
apa: Kirkpatrick, M., Johnson, T., & Barton, N. H. (2002). General models of
multilocus evolution. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/161.4.1727
chicago: Kirkpatrick, Mark, Toby Johnson, and Nicholas H Barton. “General Models
of Multilocus Evolution.” Genetics. Genetics Society of America, 2002.
https://doi.org/10.1093/genetics/161.4.1727.
ieee: M. Kirkpatrick, T. Johnson, and N. H. Barton, “General models of multilocus
evolution,” Genetics, vol. 161, no. 4. Genetics Society of America, pp.
1727–1750, 2002.
ista: Kirkpatrick M, Johnson T, Barton NH. 2002. General models of multilocus evolution.
Genetics. 161(4), 1727–1750.
mla: Kirkpatrick, Mark, et al. “General Models of Multilocus Evolution.” Genetics,
vol. 161, no. 4, Genetics Society of America, 2002, pp. 1727–50, doi:10.1093/genetics/161.4.1727.
short: M. Kirkpatrick, T. Johnson, N.H. Barton, Genetics 161 (2002) 1727–1750.
date_created: 2018-12-11T12:04:17Z
date_published: 2002-08-01T00:00:00Z
date_updated: 2023-07-11T13:20:26Z
day: '01'
doi: 10.1093/genetics/161.4.1727
extern: '1'
external_id:
pmid:
- '12196414'
intvolume: ' 161'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462196/
month: '08'
oa: 1
oa_version: Published Version
page: 1727 - 1750
pmid: 1
publication: Genetics
publication_identifier:
issn:
- 0016-6731
publication_status: published
publisher: Genetics Society of America
publist_id: '2762'
quality_controlled: '1'
scopus_import: '1'
status: public
title: General models of multilocus evolution
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 161
year: '2002'
...
---
_id: '3799'
abstract:
- lang: eng
text: 'GABAergic interneurones are diverse in their morphological and functional
properties. Perisomatic inhibitory cells show fast spiking during sustained current
injection, whereas dendritic inhibitory cells fire action potentials with lower
frequency. We examined functional and molecular properties of K(+) channels in
interneurones with horizontal dendrites in stratum oriens-alveus (OA) of the hippocampal
CA1 region, which mainly comprise somatostatin-positive dendritic inhibitory cells.
Voltage-gated K(+) currents in nucleated patches isolated from OA interneurones
consisted of three major components: a fast delayed rectifier K(+) current component
that was highly sensitive to external 4-aminopyridine (4-AP) and tetraethylammonium
(TEA) (half-maximal inhibitory concentrations < 0.1 mM for both blockers),
a slow delayed rectifier K(+) current component that was sensitive to high concentrations
of TEA, but insensitive to 4-AP, and a rapidly inactivating A-type K(+) current
component that was blocked by high concentrations of 4-AP, but resistant to TEA.
The relative contributions of these components to the macroscopic K(+) current
were estimated as 57 +/- 5, 25 +/- 6, and 19 +/- 2 %, respectively. Dendrotoxin,
a selective blocker of Kv1 channels had only minimal effects on K(+) currents
in nucleated patches. Coapplication of the membrane-permeant cAMP analogue 8-(4-chlorophenylthio)-adenosine
3'':5''-cyclic monophosphate (cpt-cAMP) and the phosphodiesterase blocker isobutyl-methylxanthine
(IBMX) resulted in a selective inhibition of the fast delayed rectifier K(+) current
component. This inhibition was absent in the presence of the protein kinase A
(PKA) inhibitor H-89, implying the involvement of PKA-mediated phosphorylation.
Single-cell reverse transcription-polymerase chain reaction (RT-PCR) analysis
revealed a high abundance of Kv3.2 mRNA in OA interneurones, whereas the expression
level of Kv3.1 mRNA was markedly lower. Similarly, RT-PCR analysis showed a high
abundance of Kv4.3 mRNA, whereas Kv4.2 mRNA was undetectable. This suggests that
the fast delayed rectifier K(+) current and the A-type K(+) current component
are mediated predominantly by homomeric Kv3.2 and Kv4.3 channels. Selective modulation
of Kv3.2 channels in OA interneurones by cAMP is likely to be an important factor
regulating the activity of dendritic inhibitory cells in principal neurone-interneurone
microcircuits.'
acknowledgement: We thank Drs J. Bischofberger, M. Heckmann, and I. Vida for critically
reading the manuscript, and A. Blomenkamp and K. Winterhalter for technical assistance.
This work was supported by a scholarship from the Deutscher Akademischer Austansch
dienst to C.-C. L., a Deutsche Forschungsgemeinschaft grant to P. J. (SFB 505/C5),
and the Alexander-von-Humboldt foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Cheng
full_name: Lien, Cheng
last_name: Lien
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Jobst
full_name: Schultz, Jobst
last_name: Schultz
- first_name: Heimo
full_name: Ehmke, Heimo
last_name: Ehmke
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. Gating, modulation and subunit
composition of voltage-gated K(+) channels in dendritic inhibitory interneurones
of rat hippocampus. Journal of Physiology. 2002;538(Pt 2):405-419. doi:10.1113/jphysiol.2001.013066
apa: Lien, C., Martina, M., Schultz, J., Ehmke, H., & Jonas, P. M. (2002). Gating,
modulation and subunit composition of voltage-gated K(+) channels in dendritic
inhibitory interneurones of rat hippocampus. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.2001.013066
chicago: Lien, Cheng, Marco Martina, Jobst Schultz, Heimo Ehmke, and Peter M Jonas.
“Gating, Modulation and Subunit Composition of Voltage-Gated K(+) Channels in
Dendritic Inhibitory Interneurones of Rat Hippocampus.” Journal of Physiology.
Wiley-Blackwell, 2002. https://doi.org/10.1113/jphysiol.2001.013066.
ieee: C. Lien, M. Martina, J. Schultz, H. Ehmke, and P. M. Jonas, “Gating, modulation
and subunit composition of voltage-gated K(+) channels in dendritic inhibitory
interneurones of rat hippocampus,” Journal of Physiology, vol. 538, no.
Pt 2. Wiley-Blackwell, pp. 405–419, 2002.
ista: Lien C, Martina M, Schultz J, Ehmke H, Jonas PM. 2002. Gating, modulation
and subunit composition of voltage-gated K(+) channels in dendritic inhibitory
interneurones of rat hippocampus. Journal of Physiology. 538(Pt 2), 405–419.
mla: Lien, Cheng, et al. “Gating, Modulation and Subunit Composition of Voltage-Gated
K(+) Channels in Dendritic Inhibitory Interneurones of Rat Hippocampus.” Journal
of Physiology, vol. 538, no. Pt 2, Wiley-Blackwell, 2002, pp. 405–19, doi:10.1113/jphysiol.2001.013066.
short: C. Lien, M. Martina, J. Schultz, H. Ehmke, P.M. Jonas, Journal of Physiology
538 (2002) 405–419.
date_created: 2018-12-11T12:05:14Z
date_published: 2002-01-01T00:00:00Z
date_updated: 2023-07-11T12:32:26Z
day: '01'
doi: 10.1113/jphysiol.2001.013066
extern: '1'
external_id:
pmid:
- '11790809'
intvolume: ' 538'
issue: Pt 2
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290075/
month: '01'
oa: 1
oa_version: Published Version
page: 405 - 419
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2411'
quality_controlled: '1'
status: public
title: Gating, modulation and subunit composition of voltage-gated K(+) channels in
dendritic inhibitory interneurones of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 538
year: '2002'
...
---
_id: '3800'
abstract:
- lang: eng
text: Networks of GABAergic interneurons are of critical importance for the generation
of gamma frequency oscillations in the brain. To examine the underlying synaptic
mechanisms, we made paired recordings from "basket cells" (BCs) in different
subfields of hippocampal slices, using transgenic mice that express enhanced green
fluorescent protein (EGFP) under the control of the parvalbumin promoter. Unitary
inhibitory postsynaptic currents (IPSCs) showed large amplitude and fast time
course with mean amplitude-weighted decay time constants of 2.5, 1.2, and 1.8
ms in the dentate gyrus, and the cornu ammonis area 3 (CA3) and 1 (CA1), respectively
(33-34 degrees C). The decay of unitary IPSCs at BC-BC synapses was significantly
faster than that at BC-principal cell synapses, indicating target cell-specific
differences in IPSC kinetics. In addition, electrical coupling was found in a
subset of BC-BC pairs. To examine whether an interneuron network with fast inhibitory
synapses can act as a gamma frequency oscillator, we developed an interneuron
network model based on experimentally determined properties. In comparison to
previous interneuron network models, our model was able to generate oscillatory
activity with higher coherence over a broad range of frequencies (20-110 Hz).
In this model, high coherence and flexibility in frequency control emerge from
the combination of synaptic properties, network structure, and electrical coupling.
acknowledgement: We thank Drs. J. Bischofberger, M. Heckmann, and R. Traub for critically
reading the manuscript. This work was supported by Deutsche Forschungsgemeinschaft
Grants SFB 505/C5 (to P.J.) and SFB 505/C6 (to M.F. and P.J.), Human Frontiers Science
Program Organization Grant RG0017/1998-B (to P.J.), and grants from the Alexander-von-Humboldt
Foundation (to P.J. and M.F.), the Schilling Foundation (to H.M.), and Novartis
(to H.M.).
article_processing_charge: No
article_type: original
author:
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Axel
full_name: Meyer, Axel
last_name: Meyer
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bartos M, Vida I, Frotscher M, et al. Fast synaptic inhibition promotes synchronized
gamma oscillations in hippocampal interneuron networks. PNAS. 2002;99(20):13222-13227.
doi:10.1073/pnas.192233099
apa: Bartos, M., Vida, I., Frotscher, M., Meyer, A., Monyer, H., Geiger, J., &
Jonas, P. M. (2002). Fast synaptic inhibition promotes synchronized gamma oscillations
in hippocampal interneuron networks. PNAS. National Academy of Sciences.
https://doi.org/10.1073/pnas.192233099
chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Axel Meyer, Hannah Monyer,
Jörg Geiger, and Peter M Jonas. “Fast Synaptic Inhibition Promotes Synchronized
Gamma Oscillations in Hippocampal Interneuron Networks.” PNAS. National
Academy of Sciences, 2002. https://doi.org/10.1073/pnas.192233099.
ieee: M. Bartos et al., “Fast synaptic inhibition promotes synchronized gamma
oscillations in hippocampal interneuron networks,” PNAS, vol. 99, no. 20.
National Academy of Sciences, pp. 13222–13227, 2002.
ista: Bartos M, Vida I, Frotscher M, Meyer A, Monyer H, Geiger J, Jonas PM. 2002.
Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal
interneuron networks. PNAS. 99(20), 13222–13227.
mla: Bartos, Marlene, et al. “Fast Synaptic Inhibition Promotes Synchronized Gamma
Oscillations in Hippocampal Interneuron Networks.” PNAS, vol. 99, no. 20,
National Academy of Sciences, 2002, pp. 13222–27, doi:10.1073/pnas.192233099.
short: M. Bartos, I. Vida, M. Frotscher, A. Meyer, H. Monyer, J. Geiger, P.M. Jonas,
PNAS 99 (2002) 13222–13227.
date_created: 2018-12-11T12:05:14Z
date_published: 2002-09-16T00:00:00Z
date_updated: 2023-07-10T13:35:18Z
day: '16'
doi: 10.1073/pnas.192233099
extern: '1'
external_id:
pmid:
- '12235359'
intvolume: ' 99'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC130614/
month: '09'
oa: 1
oa_version: Published Version
page: 13222 - 13227
pmid: 1
publication: PNAS
publication_identifier:
issn:
- 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2409'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal
interneuron networks
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 99
year: '2002'
...
---
_id: '3801'
abstract:
- lang: eng
text: 'To examine possible interactions between fast depression and modulation of
inhibitory synaptic transmission in the hippocampus, we recorded from pairs of
synaptically connected basket cells (BCs) and granule cells (GCs) in the dentate
gyrus of rat brain slices at 34 degrees C. Multiple-pulse depression (MPD) was
examined in trains of 5 or 10 inhibitory postsynaptic currents (IPSCs) evoked
at frequencies of 10-100 Hz under several conditions that inhibit transmitter
release: block of voltage-dependent Ca2+ channels by Cd2+ (10 microM), activation
of gamma-amino-butyric acid type B receptors (GABA(B)Rs) by baclofen (10 microM)
and activation of muscarinic acetylcholine receptors (mAchRs) by carbachol (2
microM). All manipulations led to a substantial inhibition of synaptic transmission,
reducing the amplitude of the first IPSC in the train (IPSC1) by 72%, 61% and
29%, respectively. However, MPD was largely preserved under these conditions (0.34
in control versus 0.31, 0.50 and 0.47 in the respective conditions at 50 Hz).
Similarly, a theta burst stimulation (TBS) protocol reduced IPSC1 by 54%, but
left MPD unchanged (0.40 in control and 0.39 during TBS). Analysis of both fractions
of transmission failures and coefficients of variation (CV) of IPSC peak amplitudes
suggested that MPD had a presynaptic expression site, independent of release probability.
In conclusion, different types of presynaptic modulation of inhibitory synaptic
transmission converge on a reduction of synaptic strength, while short-term dynamics
are largely unchanged.'
acknowledgement: We thank Drs M. Bartos, J. Bischofberger, M. Heckmann and
I. Vida for critically reading the manuscript, Dr K. Götz for providing information about pharmacological properties of
inhibitory hippocampal synapses, and A. Blomenkamp and K. Winterhalter for
technical assistance. This work was supported by Deutsche Forschungsgemeinschaft
grants to P.J. (Jo-248/2-2,SFB 505/C5) and the Alexander-von-Humboldt foundation.
article_processing_charge: No
article_type: original
author:
- first_name: Stefan
full_name: Hefft, Stefan
last_name: Hefft
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Hefft S, Kraushaar U, Geiger J, Jonas PM. Presynaptic short-term depression
is maintained during regulation of transmitter release at a GABAergic synapse
in rat hippocampus. Journal of Physiology. 2002;539(Pt 1):201-208. doi:10.1113/jphysiol.2001.013455
apa: Hefft, S., Kraushaar, U., Geiger, J., & Jonas, P. M. (2002). Presynaptic
short-term depression is maintained during regulation of transmitter release at
a GABAergic synapse in rat hippocampus. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.2001.013455
chicago: Hefft, Stefan, Udo Kraushaar, Jörg Geiger, and Peter M Jonas. “Presynaptic
Short-Term Depression Is Maintained during Regulation of Transmitter Release at
a GABAergic Synapse in Rat Hippocampus.” Journal of Physiology. Wiley-Blackwell,
2002. https://doi.org/10.1113/jphysiol.2001.013455.
ieee: S. Hefft, U. Kraushaar, J. Geiger, and P. M. Jonas, “Presynaptic short-term
depression is maintained during regulation of transmitter release at a GABAergic
synapse in rat hippocampus,” Journal of Physiology, vol. 539, no. Pt 1.
Wiley-Blackwell, pp. 201–8, 2002.
ista: Hefft S, Kraushaar U, Geiger J, Jonas PM. 2002. Presynaptic short-term depression
is maintained during regulation of transmitter release at a GABAergic synapse
in rat hippocampus. Journal of Physiology. 539(Pt 1), 201–8.
mla: Hefft, Stefan, et al. “Presynaptic Short-Term Depression Is Maintained during
Regulation of Transmitter Release at a GABAergic Synapse in Rat Hippocampus.”
Journal of Physiology, vol. 539, no. Pt 1, Wiley-Blackwell, 2002, pp. 201–08,
doi:10.1113/jphysiol.2001.013455.
short: S. Hefft, U. Kraushaar, J. Geiger, P.M. Jonas, Journal of Physiology 539
(2002) 201–8.
date_created: 2018-12-11T12:05:15Z
date_published: 2002-02-01T00:00:00Z
date_updated: 2023-07-11T10:01:12Z
day: '01'
doi: 10.1113/jphysiol.2001.013455
extern: '1'
external_id:
pmid:
- '11850513'
intvolume: ' 539'
issue: Pt 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2290140/
month: '02'
oa: 1
oa_version: Published Version
page: 201 - 8
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2410'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Presynaptic short-term depression is maintained during regulation of transmitter
release at a GABAergic synapse in rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 539
year: '2002'
...
---
_id: '3802'
abstract:
- lang: eng
text: The presynaptic Ca2+ signal is a key determinant of transmitter release at
chemical synapses. In cortical synaptic terminals, however, little is known about
the kinetic properties of the presynaptic Ca2+ channels. To investigate the timing
and magnitude of the presynaptic Ca2+ inflow, we performed whole-cell patch-clamp
recordings from mossy fiber boutons (MFBs) in rat hippocampus. MFBs showed large
high-voltage-activated Ca(2+) currents, with a maximal amplitude of approximately
100 pA at a membrane potential of 0 mV. Both activation and deactivation were
fast, with time constants in the submillisecond range at a temperature of approximately
23 degrees C. An MFB action potential (AP) applied as a voltage-clamp command
evoked a transient Ca2+ current with an average amplitude of approximately 170
pA and a half-duration of 580 microsec. A prepulse to +40 mV had only minimal
effects on the AP-evoked Ca2+ current, indicating that presynaptic APs open the
voltage-gated Ca2+ channels very effectively. On the basis of the experimental
data, we developed a kinetic model with four closed states and one open state,
linked by voltage-dependent rate constants. Simulations of the Ca2+ current could
reproduce the experimental data, including the large amplitude and rapid time
course of the current evoked by MFB APs. Furthermore, the simulations indicate
that the shape of the presynaptic AP and the gating kinetics of the Ca2+ channels
are tuned to produce a maximal Ca2+ influx during a minimal period of time. The
precise timing and high efficacy of Ca2+ channel activation at this cortical glutamatergic
synapse may be important for synchronous transmitter release and temporal information
processing.
acknowledgement: J.B. was supported by grants from the Deutsche Forschungsgemeinschaft
(Bi 642/1-2 and SFB 505/C9). We thank Dr. U. Kraushaar, Dr. S. Hefft, and C. Schmidt-Hieber
for critically reading this manuscript, F. Heyde for secretarial help, and A. Blomenkamp
and K. Winterhalter for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Josef
full_name: Bischofberger, Josef
last_name: Bischofberger
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bischofberger J, Geiger J, Jonas PM. Timing and efficacy of Ca(2+) channel
activation in hippocampal mossy fiber boutons. Journal of Neuroscience.
2002;22(24):10593-10602. doi:10.1523/JNEUROSCI.22-24-10593.2002
apa: Bischofberger, J., Geiger, J., & Jonas, P. M. (2002). Timing and efficacy
of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of
Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002
chicago: Bischofberger, Josef, Jörg Geiger, and Peter M Jonas. “Timing and Efficacy
of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” Journal of
Neuroscience. Society for Neuroscience, 2002. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002.
ieee: J. Bischofberger, J. Geiger, and P. M. Jonas, “Timing and efficacy of Ca(2+)
channel activation in hippocampal mossy fiber boutons,” Journal of Neuroscience,
vol. 22, no. 24. Society for Neuroscience, pp. 10593–10602, 2002.
ista: Bischofberger J, Geiger J, Jonas PM. 2002. Timing and efficacy of Ca(2+) channel
activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 22(24),
10593–10602.
mla: Bischofberger, Josef, et al. “Timing and Efficacy of Ca(2+) Channel Activation
in Hippocampal Mossy Fiber Boutons.” Journal of Neuroscience, vol. 22,
no. 24, Society for Neuroscience, 2002, pp. 10593–602, doi:10.1523/JNEUROSCI.22-24-10593.2002.
short: J. Bischofberger, J. Geiger, P.M. Jonas, Journal of Neuroscience 22 (2002)
10593–10602.
date_created: 2018-12-11T12:05:15Z
date_published: 2002-12-01T00:00:00Z
date_updated: 2023-06-13T13:19:45Z
day: '01'
doi: 10.1523/JNEUROSCI.22-24-10593.2002
extern: '1'
external_id:
pmid:
- '12486151'
intvolume: ' 22'
issue: '24'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758411/
month: '12'
oa: 1
oa_version: Published Version
page: 10593 - 10602
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2407'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber
boutons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '2002'
...
---
_id: '3919'
abstract:
- lang: eng
text: Hamilton's concept of local mate competition (LMC) is the standard model to
explain female-biased sex ratios in solitary Hymenoptera. In social Hymenoptera,
however, LMC has remained controversial, mainly because manipulation of sex allocation
by workers in response to relatedness asymmetries is an additional powerful mechanism
of female bias. Furthermore, the predominant mating systems in the social insects
are thought to make LMC unlikely. Nevertheless, several species exist in which
dispersal of males is limited and mating occurs in the nest. Some of these species,
such as the ant Cardiocondyla obscurior, have evolved dimorphic males, with one
morph being specialized for dispersal and the other for fighting with nest-mate
males over access to females. Such life history, combining sociality and alternative
reproductive tactics in males, provides a unique opportunity to test the power
of LMC as a selective force leading to female-biased sex ratios in social Hymenoptera.
We show that, in concordance with LMC predictions, an experimental increase in
queen number leads to a shift in sex allocation in favour of non-dispersing males,
but does not influence the proportion of disperser males. Furthermore, we can
assign this change in sex allocation at the colony level to the queens and rule
out worker manipulation.
acknowledgement: 'We thank A. F. G. Bourke, J. J. Boomsma, S. Foitzik, M. Sixt,C.
Anderson and C. Schubart for improving the manuscript, and E. Sixt for ant illustrations (figure 2). This study was
funded by the DFG (Deutsche Forschungsgemeinschaft: He1623/7-2).'
article_processing_charge: No
article_type: original
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Jürgen
full_name: Heinze, Jürgen
last_name: Heinze
citation:
ama: 'Cremer S, Heinze J. Adaptive production of fighter males: queens of the ant
Cardiocondyla adjust the sex ratio under local mate competition. Proceedings
of the Royal Society of London Series B Biological Sciences. 2002;269(1489):417-422.
doi:10.1098/rspb.2001.1892'
apa: 'Cremer, S., & Heinze, J. (2002). Adaptive production of fighter males:
queens of the ant Cardiocondyla adjust the sex ratio under local mate competition.
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society, The. https://doi.org/10.1098/rspb.2001.1892'
chicago: 'Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males:
Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.”
Proceedings of the Royal Society of London Series B Biological Sciences.
Royal Society, The, 2002. https://doi.org/10.1098/rspb.2001.1892.'
ieee: 'S. Cremer and J. Heinze, “Adaptive production of fighter males: queens of
the ant Cardiocondyla adjust the sex ratio under local mate competition,” Proceedings
of the Royal Society of London Series B Biological Sciences, vol. 269, no.
1489. Royal Society, The, pp. 417–422, 2002.'
ista: 'Cremer S, Heinze J. 2002. Adaptive production of fighter males: queens of
the ant Cardiocondyla adjust the sex ratio under local mate competition. Proceedings
of the Royal Society of London Series B Biological Sciences. 269(1489), 417–422.'
mla: 'Cremer, Sylvia, and Jürgen Heinze. “Adaptive Production of Fighter Males:
Queens of the Ant Cardiocondyla Adjust the Sex Ratio under Local Mate Competition.”
Proceedings of the Royal Society of London Series B Biological Sciences,
vol. 269, no. 1489, Royal Society, The, 2002, pp. 417–22, doi:10.1098/rspb.2001.1892.'
short: S. Cremer, J. Heinze, Proceedings of the Royal Society of London Series B
Biological Sciences 269 (2002) 417–422.
date_created: 2018-12-11T12:05:53Z
date_published: 2002-02-22T00:00:00Z
date_updated: 2023-06-13T11:52:17Z
day: '22'
doi: 10.1098/rspb.2001.1892
extern: '1'
external_id:
pmid:
- '11886631'
intvolume: ' 269'
issue: '1489'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1690910/
month: '02'
oa: 1
oa_version: None
page: 417 - 422
pmid: 1
publication: Proceedings of the Royal Society of London Series B Biological Sciences
publication_identifier:
issn:
- 0962-8452
publication_status: published
publisher: Royal Society, The
publist_id: '2231'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Adaptive production of fighter males: queens of the ant Cardiocondyla adjust
the sex ratio under local mate competition'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 269
year: '2002'
...