---
_id: '3775'
abstract:
- lang: eng
  text: There is a close analogy between statistical thermodynamics and the evolution
    of allele frequencies under mutation, selection and random drift. Wright's formula
    for the stationary distribution of allele frequencies is analogous to the Boltzmann
    distribution in statistical physics. Population size, 2N, plays the role of the
    inverse temperature, 1/kT, and determines the magnitude of random fluctuations.
    Log mean fitness, View the MathML source, tends to increase under selection, and
    is analogous to a (negative) energy; a potential function, U, increases under
    mutation in a similar way. An entropy, SH, can be defined which measures the deviation
    from the distribution of allele frequencies expected under random drift alone;
    the sum View the MathML source gives a free fitness that increases as the population
    evolves towards its stationary distribution. Usually, we observe the distribution
    of a few quantitative traits that depend on the frequencies of very many alleles.
    The mean and variance of such traits are analogous to observable quantities in
    statistical thermodynamics. Thus, we can define an entropy, SΩ, which measures
    the volume of allele frequency space that is consistent with the observed trait
    distribution. The stationary distribution of the traits is View the MathML source;
    this applies with arbitrary epistasis and dominance. The entropies SΩ, SH are
    distinct, but converge when there are so many alleles that traits fluctuate close
    to their expectations. Populations tend to evolve towards states that can be realised
    in many ways (i.e., large SΩ), which may lead to a substantial drop below the
    adaptive peak; we illustrate this point with a simple model of genetic redundancy.
    This analogy with statistical thermodynamics brings together previous ideas in
    a general framework, and justifies a maximum entropy approximation to the dynamics
    of quantitative traits.
acknowledgement: "This work was supported by a Royal Society/Wolfson Award, and by
  grants EP/T11753/01, EP/C546318/01 from the EPSRC.\r\nWe are grateful to M. Cates,
  H.P. de Vladar and G. Sella, and to two anonymous referees, for their helpful comments."
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Jason
  full_name: Coe, Jason
  last_name: Coe
citation:
  ama: Barton NH, Coe J. On the application of statistical physics to evolutionary
    biology. <i>Journal of Theoretical Biology</i>. 2009;259(2):317-324. doi:<a href="https://doi.org/10.1016/j.jtbi.2009.03.019">10.1016/j.jtbi.2009.03.019</a>
  apa: Barton, N. H., &#38; Coe, J. (2009). On the application of statistical physics
    to evolutionary biology. <i>Journal of Theoretical Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.jtbi.2009.03.019">https://doi.org/10.1016/j.jtbi.2009.03.019</a>
  chicago: Barton, Nicholas H, and Jason Coe. “On the Application of Statistical Physics
    to Evolutionary Biology.” <i>Journal of Theoretical Biology</i>. Elsevier, 2009.
    <a href="https://doi.org/10.1016/j.jtbi.2009.03.019">https://doi.org/10.1016/j.jtbi.2009.03.019</a>.
  ieee: N. H. Barton and J. Coe, “On the application of statistical physics to evolutionary
    biology,” <i>Journal of Theoretical Biology</i>, vol. 259, no. 2. Elsevier, pp.
    317–324, 2009.
  ista: Barton NH, Coe J. 2009. On the application of statistical physics to evolutionary
    biology. Journal of Theoretical Biology. 259(2), 317–324.
  mla: Barton, Nicholas H., and Jason Coe. “On the Application of Statistical Physics
    to Evolutionary Biology.” <i>Journal of Theoretical Biology</i>, vol. 259, no.
    2, Elsevier, 2009, pp. 317–24, doi:<a href="https://doi.org/10.1016/j.jtbi.2009.03.019">10.1016/j.jtbi.2009.03.019</a>.
  short: N.H. Barton, J. Coe, Journal of Theoretical Biology 259 (2009) 317–324.
date_created: 2018-12-11T12:05:06Z
date_published: 2009-07-21T00:00:00Z
date_updated: 2021-01-12T07:52:06Z
day: '21'
department:
- _id: NiBa
doi: 10.1016/j.jtbi.2009.03.019
intvolume: '       259'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://hal.archives-ouvertes.fr/hal-00554594/document
month: '07'
oa: 1
oa_version: Submitted Version
page: 317 - 324
publication: Journal of Theoretical Biology
publication_status: published
publisher: Elsevier
publist_id: '2452'
quality_controlled: '1'
scopus_import: 1
status: public
title: On the application of statistical physics to evolutionary biology
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 259
year: '2009'
...
---
_id: '3780'
abstract:
- lang: eng
  text: Why are sinistral snails so rare? Two main hypotheses are that selection acts
    against the establishment of new coiling morphs, because dextral and sinistral
    snails have trouble mating, or else a developmental constraint prevents the establishment
    of sinistrals. We therefore used an isolate of the snail Lymnaea stagnalis, in
    which sinistrals are rare, and populations of Partula suturalis, in which sinistrals
    are common, as well as a mathematical model, to understand the circumstances by
    which new morphs evolve. The main finding is that the sinistral genotype is associated
    with reduced egg viability in L. stagnalis, but in P. suturalis individuals of
    sinistral and dextral genotype appear equally fecund, implying a lack of a constraint.
    As positive frequency-dependent selection against the rare chiral morph in P.
    suturalis also operates over a narrow range (&lt; 3%), the results suggest a model
    for chiral evolution in snails in which weak positive frequency-dependent selection
    may be overcome by a negative frequency-dependent selection, such as reproductive
    character displacement. In snails, there is not always a developmental constraint.
    As the direction of cleavage, and thus the directional asymmetry of the entire
    body, does not generally vary in other Spiralia (annelids, echiurans, vestimentiferans,
    sipunculids and nemerteans), it remains an open question as to whether this is
    because of a constraint and/or because most taxa do not have a conspicuous external
    asymmetry (like a shell) upon which selection can act.
acknowledgement: We owe a great debt to Jim Murray for his many contributions to the
  study of Partula, in the field, in the laboratory, in the interpretation of data,
  and in generating new ideas about evolution. With pleasure and respect we dedicate
  this paper to him. Jim Murray played a leading role in making the collections used
  here. We are very grateful also to Ann Clarke and Elizabeth Murray for help with
  collecting, to Lorna Stewart for snail dissections, to Joris Koene for the gift
  of snails, to Natasha Constant for entering the data, and Takahiro Asami, Edmund
  Gittenberger and Gerhard Falkner for establishing the sinistral stock of L. stagnalis.
  Comments from an anonymous referee, A. Richard Palmer and the editorial board improved
  the manuscript. Work in the field was supported by the Royal Society, The Carnegie
  Trust, the Percy Sladen Trust and the National Science Foundation. The Science Research
  Council (B/SR/4144), the National Science Foundation (GB-4188), the Royal Society
  and the University of Nottingham supported work in the laboratory.
author:
- first_name: Angus
  full_name: Davison, Angus
  last_name: Davison
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Bryan
  full_name: Clarke, Bryan
  last_name: Clarke
citation:
  ama: 'Davison A, Barton NH, Clarke B. The effect of chirality phenotype and genotype
    on the fecundity and viability of Partula suturalis and Lymnaea stagnalis: Implications
    for the evolution of sinistral snails. <i>Journal of Evolutionary Biology</i>.
    2009;22(8):1624-1635. doi:<a href="https://doi.org/10.1111/j.1420-9101.2009.01770.x">10.1111/j.1420-9101.2009.01770.x</a>'
  apa: 'Davison, A., Barton, N. H., &#38; Clarke, B. (2009). The effect of chirality
    phenotype and genotype on the fecundity and viability of Partula suturalis and
    Lymnaea stagnalis: Implications for the evolution of sinistral snails. <i>Journal
    of Evolutionary Biology</i>. Wiley. <a href="https://doi.org/10.1111/j.1420-9101.2009.01770.x">https://doi.org/10.1111/j.1420-9101.2009.01770.x</a>'
  chicago: 'Davison, Angus, Nicholas H Barton, and Bryan Clarke. “The Effect of Chirality
    Phenotype and Genotype on the Fecundity and Viability of Partula Suturalis and
    Lymnaea Stagnalis: Implications for the Evolution of Sinistral Snails.” <i>Journal
    of Evolutionary Biology</i>. Wiley, 2009. <a href="https://doi.org/10.1111/j.1420-9101.2009.01770.x">https://doi.org/10.1111/j.1420-9101.2009.01770.x</a>.'
  ieee: 'A. Davison, N. H. Barton, and B. Clarke, “The effect of chirality phenotype
    and genotype on the fecundity and viability of Partula suturalis and Lymnaea stagnalis:
    Implications for the evolution of sinistral snails,” <i>Journal of Evolutionary
    Biology</i>, vol. 22, no. 8. Wiley, pp. 1624–1635, 2009.'
  ista: 'Davison A, Barton NH, Clarke B. 2009. The effect of chirality phenotype and
    genotype on the fecundity and viability of Partula suturalis and Lymnaea stagnalis:
    Implications for the evolution of sinistral snails. Journal of Evolutionary Biology.
    22(8), 1624–1635.'
  mla: 'Davison, Angus, et al. “The Effect of Chirality Phenotype and Genotype on
    the Fecundity and Viability of Partula Suturalis and Lymnaea Stagnalis: Implications
    for the Evolution of Sinistral Snails.” <i>Journal of Evolutionary Biology</i>,
    vol. 22, no. 8, Wiley, 2009, pp. 1624–35, doi:<a href="https://doi.org/10.1111/j.1420-9101.2009.01770.x">10.1111/j.1420-9101.2009.01770.x</a>.'
  short: A. Davison, N.H. Barton, B. Clarke, Journal of Evolutionary Biology 22 (2009)
    1624–1635.
date_created: 2018-12-11T12:05:08Z
date_published: 2009-08-01T00:00:00Z
date_updated: 2021-01-12T07:52:09Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/j.1420-9101.2009.01770.x
file:
- access_level: open_access
  checksum: f70c15c6ab9306121d4153a3be0d2346
  content_type: application/pdf
  creator: dernst
  date_created: 2019-02-22T09:21:44Z
  date_updated: 2020-07-14T12:46:15Z
  file_id: '6044'
  file_name: Davison_JEB_v31_2009.pdf
  file_size: 2583812
  relation: main_file
file_date_updated: 2020-07-14T12:46:15Z
has_accepted_license: '1'
intvolume: '        22'
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Submitted Version
page: 1624 - 1635
publication: Journal of Evolutionary Biology
publication_status: published
publisher: Wiley
publist_id: '2447'
pubrep_id: '553'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'The effect of chirality phenotype and genotype on the fecundity and viability
  of Partula suturalis and Lymnaea stagnalis: Implications for the evolution of sinistral
  snails'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2009'
...
---
_id: '3837'
abstract:
- lang: eng
  text: In this paper we extend the work of Alfaro, Henzinger et al. on interface
    theories for component-based design. Existing interface theories often fail to
    capture functional relations between the inputs and outputs of an interface. For
    example, a simple synchronous interface that takes as input a number n ≥ 0 and
    returns, at the same time, as output n + 1, cannot be expressed in existing theories.
    In this paper we provide a theory of relational interfaces, where such input-output
    relations can be captured. Our theory supports synchronous interfaces, both stateless
    and stateful. It includes explicit notions of environments and pluggability, and
    satisfies fundamental properties such as preservation of refinement by composition,
    and characterization of pluggability by refinement. We achieve these properties
    by making reasonable restrictions on feedback loops in interface compositions.
acknowledgement: 'This work is supported by the Center for Hybrid and Embedded Software
  Systems (CHESS) at UC Berkeley, which receives support from the National Science
  Foundation (NSF awards #0720882 (CSR-EHS: PRET) and #0720841 (CSR-CPS)), the U.S.
  Army Research Office (ARO #W911NF-07-2-0019), the U.S. Air Force Office of Scientific
  Research (MURI #FA9550-06-0312), the Air Force Research Lab (AFRL), the State of
  California Micro Program, and the following companies: Agilent, Bosch, Lockheed-Martin,
  National Instruments, Thales and Toyota. This work is also supported by the COMBEST
  and ArtistDesign projects of the European Union, and the Swiss National Science
  Foundation. '
author:
- first_name: Stavros
  full_name: Tripakis, Stavros
  last_name: Tripakis
- first_name: Ben
  full_name: Lickly, Ben
  last_name: Lickly
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Edward
  full_name: Lee, Edward
  last_name: Lee
citation:
  ama: 'Tripakis S, Lickly B, Henzinger TA, Lee E. On relational interfaces. In: <i>EMSOFT
    ’09 Proceedings of the Seventh ACM International Conference on Embedded Software</i>.
    ACM; 2009:67-76. doi:<a href="https://doi.org/10.1145/1629335.1629346">10.1145/1629335.1629346</a>'
  apa: 'Tripakis, S., Lickly, B., Henzinger, T. A., &#38; Lee, E. (2009). On relational
    interfaces. In <i>EMSOFT ’09 Proceedings of the seventh ACM international conference
    on Embedded software</i> (pp. 67–76). Grenoble, France: ACM. <a href="https://doi.org/10.1145/1629335.1629346">https://doi.org/10.1145/1629335.1629346</a>'
  chicago: Tripakis, Stavros, Ben Lickly, Thomas A Henzinger, and Edward Lee. “On
    Relational Interfaces.” In <i>EMSOFT ’09 Proceedings of the Seventh ACM International
    Conference on Embedded Software</i>, 67–76. ACM, 2009. <a href="https://doi.org/10.1145/1629335.1629346">https://doi.org/10.1145/1629335.1629346</a>.
  ieee: S. Tripakis, B. Lickly, T. A. Henzinger, and E. Lee, “On relational interfaces,”
    in <i>EMSOFT ’09 Proceedings of the seventh ACM international conference on Embedded
    software</i>, Grenoble, France, 2009, pp. 67–76.
  ista: 'Tripakis S, Lickly B, Henzinger TA, Lee E. 2009. On relational interfaces.
    EMSOFT ’09 Proceedings of the seventh ACM international conference on Embedded
    software. EMSOFT: Embedded Software , 67–76.'
  mla: Tripakis, Stavros, et al. “On Relational Interfaces.” <i>EMSOFT ’09 Proceedings
    of the Seventh ACM International Conference on Embedded Software</i>, ACM, 2009,
    pp. 67–76, doi:<a href="https://doi.org/10.1145/1629335.1629346">10.1145/1629335.1629346</a>.
  short: S. Tripakis, B. Lickly, T.A. Henzinger, E. Lee, in:, EMSOFT ’09 Proceedings
    of the Seventh ACM International Conference on Embedded Software, ACM, 2009, pp.
    67–76.
conference:
  end_date: 2009-10-16
  location: Grenoble, France
  name: 'EMSOFT: Embedded Software '
  start_date: 2009-10-12
date_created: 2018-12-11T12:05:26Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:33Z
day: '01'
ddc:
- '004'
department:
- _id: ToHe
doi: 10.1145/1629335.1629346
ec_funded: 1
file:
- access_level: open_access
  checksum: 3a70e21527dfaad2f198549ae5710786
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:13:57Z
  date_updated: 2020-07-14T12:46:16Z
  file_id: '5045'
  file_name: IST-2012-70-v1+1_On_Relational_Interfaces.pdf
  file_size: 310902
  relation: main_file
file_date_updated: 2020-07-14T12:46:16Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 67 - 76
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '215543'
  name: COMponent-Based Embedded Systems design Techniques
- _id: 25F1337C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '214373'
  name: Design for Embedded Systems
publication: EMSOFT '09 Proceedings of the seventh ACM international conference on
  Embedded software
publication_status: published
publisher: ACM
publist_id: '2360'
pubrep_id: '70'
quality_controlled: '1'
status: public
title: On relational interfaces
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2009'
...
---
_id: '3841'
abstract:
- lang: eng
  text: 'We compare several languages for specifying Markovian population models such
    as queuing networks and chemical reaction networks. These languages —matrix descriptions,
    stochastic Petri nets, stoichiometric equations, stochastic process algebras,
    and guarded command models— all describe continuous-time Markov chains, but they
    differ according to important properties, such as compositionality, expressiveness
    and succinctness, executability, ease of use, and the support they provide for
    checking the well-formedness of a model and for analyzing a model. '
acknowledgement: This research was supported in part by the Excellence Cluster on
  Multimodal Computing and Interaction and the Swiss National Science Foundation.
alternative_title:
- LNCS
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Barbara
  full_name: Jobstmann, Barbara
  last_name: Jobstmann
- first_name: Verena
  full_name: Wolf, Verena
  last_name: Wolf
citation:
  ama: 'Henzinger TA, Jobstmann B, Wolf V. Formalisms for specifying Markovian population
    models. In: Vol 5797. Springer; 2009:3-23. doi:<a href="https://doi.org/10.1007/978-3-642-04420-5_2">10.1007/978-3-642-04420-5_2</a>'
  apa: 'Henzinger, T. A., Jobstmann, B., &#38; Wolf, V. (2009). Formalisms for specifying
    Markovian population models (Vol. 5797, pp. 3–23). Presented at the RP: Reachability
    Problems, Palaiseau, France: Springer. <a href="https://doi.org/10.1007/978-3-642-04420-5_2">https://doi.org/10.1007/978-3-642-04420-5_2</a>'
  chicago: Henzinger, Thomas A, Barbara Jobstmann, and Verena Wolf. “Formalisms for
    Specifying Markovian Population Models,” 5797:3–23. Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-04420-5_2">https://doi.org/10.1007/978-3-642-04420-5_2</a>.
  ieee: 'T. A. Henzinger, B. Jobstmann, and V. Wolf, “Formalisms for specifying Markovian
    population models,” presented at the RP: Reachability Problems, Palaiseau, France,
    2009, vol. 5797, pp. 3–23.'
  ista: 'Henzinger TA, Jobstmann B, Wolf V. 2009. Formalisms for specifying Markovian
    population models. RP: Reachability Problems, LNCS, vol. 5797, 3–23.'
  mla: Henzinger, Thomas A., et al. <i>Formalisms for Specifying Markovian Population
    Models</i>. Vol. 5797, Springer, 2009, pp. 3–23, doi:<a href="https://doi.org/10.1007/978-3-642-04420-5_2">10.1007/978-3-642-04420-5_2</a>.
  short: T.A. Henzinger, B. Jobstmann, V. Wolf, in:, Springer, 2009, pp. 3–23.
conference:
  end_date: 2009-09-25
  location: Palaiseau, France
  name: 'RP: Reachability Problems'
  start_date: 2009-09-23
date_created: 2018-12-11T12:05:28Z
date_published: 2009-09-07T00:00:00Z
date_updated: 2023-02-23T11:24:49Z
day: '07'
ddc:
- '005'
department:
- _id: ToHe
doi: 10.1007/978-3-642-04420-5_2
file:
- access_level: open_access
  checksum: df88431872586c773fbcfea37d7b36a2
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:41Z
  date_updated: 2020-07-14T12:46:16Z
  file_id: '4702'
  file_name: IST-2012-67-v1+1_Formalisms_for_specifying_Markovian_population_models.pdf
  file_size: 222840
  relation: main_file
file_date_updated: 2020-07-14T12:46:16Z
has_accepted_license: '1'
intvolume: '      5797'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 3 - 23
publication_status: published
publisher: Springer
publist_id: '2352'
pubrep_id: '67'
quality_controlled: '1'
related_material:
  record:
  - id: '3381'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: Formalisms for specifying Markovian population models
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5797
year: '2009'
...
---
_id: '3843'
abstract:
- lang: eng
  text: "Within systems biology there is an increasing interest in the stochastic
    behavior of biochemical reaction networks. An appropriate stochastic description
    is provided by the chemical master equation, which represents a continuous- time
    Markov chain (CTMC).\r\nStandard Uniformization (SU) is an efficient method for
    the transient analysis of CTMCs. For systems with very different time scales,
    such as biochemical reaction networks, SU is computationally expensive. In these
    cases, a variant of SU, called adaptive uniformization (AU), is known to reduce
    the large number of iterations needed by SU. The additional difficulty of AU is
    that it requires the solution of a birth process.\r\nIn this paper we present
    an on-the-fly variant of AU, where we improve the original algorithm for AU at
    the cost of a small approximation error. By means of several examples, we show
    that our approach is particularly well-suited for biochemical reaction networks."
acknowledgement: This research has been partially funded by the Swiss National Science
  Foundation under grant 205321-111840 and by the Cluster of Excellence on Multimodal
  Computing and Interaction at Saarland University.
article_processing_charge: No
author:
- first_name: Frédéric
  full_name: Didier, Frédéric
  last_name: Didier
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Maria
  full_name: Mateescu, Maria
  id: 3B43276C-F248-11E8-B48F-1D18A9856A87
  last_name: Mateescu
- first_name: Verena
  full_name: Wolf, Verena
  last_name: Wolf
citation:
  ama: 'Didier F, Henzinger TA, Mateescu M, Wolf V. Fast adaptive uniformization of
    the chemical master equation. In: Vol 4. IEEE; 2009:118-127. doi:<a href="https://doi.org/10.1109/HiBi.2009.23">10.1109/HiBi.2009.23</a>'
  apa: 'Didier, F., Henzinger, T. A., Mateescu, M., &#38; Wolf, V. (2009). Fast adaptive
    uniformization of the chemical master equation (Vol. 4, pp. 118–127). Presented
    at the HIBI: High-Performance Computational Systems Biology, Trento, Italy: IEEE.
    <a href="https://doi.org/10.1109/HiBi.2009.23">https://doi.org/10.1109/HiBi.2009.23</a>'
  chicago: Didier, Frédéric, Thomas A Henzinger, Maria Mateescu, and Verena Wolf.
    “Fast Adaptive Uniformization of the Chemical Master Equation,” 4:118–27. IEEE,
    2009. <a href="https://doi.org/10.1109/HiBi.2009.23">https://doi.org/10.1109/HiBi.2009.23</a>.
  ieee: 'F. Didier, T. A. Henzinger, M. Mateescu, and V. Wolf, “Fast adaptive uniformization
    of the chemical master equation,” presented at the HIBI: High-Performance Computational
    Systems Biology, Trento, Italy, 2009, vol. 4, no. 6, pp. 118–127.'
  ista: 'Didier F, Henzinger TA, Mateescu M, Wolf V. 2009. Fast adaptive uniformization
    of the chemical master equation. HIBI: High-Performance Computational Systems
    Biology vol. 4, 118–127.'
  mla: Didier, Frédéric, et al. <i>Fast Adaptive Uniformization of the Chemical Master
    Equation</i>. Vol. 4, no. 6, IEEE, 2009, pp. 118–27, doi:<a href="https://doi.org/10.1109/HiBi.2009.23">10.1109/HiBi.2009.23</a>.
  short: F. Didier, T.A. Henzinger, M. Mateescu, V. Wolf, in:, IEEE, 2009, pp. 118–127.
conference:
  end_date: 2009-10-16
  location: Trento, Italy
  name: 'HIBI: High-Performance Computational Systems Biology'
  start_date: 2009-10-14
date_created: 2018-12-11T12:05:28Z
date_published: 2009-10-30T00:00:00Z
date_updated: 2023-02-23T11:45:05Z
day: '30'
ddc:
- '000'
department:
- _id: ToHe
- _id: CaGu
doi: 10.1109/HiBi.2009.23
file:
- access_level: open_access
  checksum: 9a3bde48f43203991a0b3c6a277c2f5b
  content_type: application/pdf
  creator: dernst
  date_created: 2020-05-19T16:33:55Z
  date_updated: 2020-07-14T12:46:17Z
  file_id: '7874'
  file_name: 2009_HIBI_Didier.pdf
  file_size: 222890
  relation: main_file
file_date_updated: 2020-07-14T12:46:17Z
has_accepted_license: '1'
intvolume: '         4'
issue: '6'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
page: 118 - 127
publication_status: published
publisher: IEEE
publist_id: '2348'
quality_controlled: '1'
related_material:
  record:
  - id: '3842'
    relation: later_version
    status: public
scopus_import: 1
status: public
title: Fast adaptive uniformization of the chemical master equation
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 4
year: '2009'
...
---
_id: '3844'
abstract:
- lang: eng
  text: The Hierarchical Timing Language (HTL) is a real-time coordination language
    for distributed control systems. HTL programs must be checked for well-formedness,
    race freedom, transmission safety (schedulability of inter-host communication),
    and time safety (schedulability of host computation). We present a modular abstract
    syntax and semantics for HTL, modular checks of well-formedness, race freedom,
    and transmission safety, and modular code distribution. Our contributions here
    complement previous results on HTL time safety and modular code generation. Modularity
    in HTL can be utilized in easy program composition as well as fast program analysis
    and code generation, but also in so-called runtime patching, where program components
    may be modified at runtime.
acknowledgement: Supported by the EU ArtistDesign Network of Excellence on Embedded
  Systems Design, the EU project COMBEST, the Austrian Science Funds P18913-N15 and
  V00125, and Fundacao para a Ciencia e Tecnologia funds SFRH/BD/29461/2006 and PTDC/EIA/71462/2006
author:
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Christoph
  full_name: Kirsch, Christoph
  last_name: Kirsch
- first_name: Eduardo
  full_name: Marques, Eduardo
  last_name: Marques
- first_name: Ana
  full_name: Sokolova, Ana
  last_name: Sokolova
citation:
  ama: 'Henzinger TA, Kirsch C, Marques E, Sokolova A. Distributed, modular HTL. In:
    IEEE; 2009:171-180. doi:<a href="https://doi.org/10.1109/RTSS.2009.9">10.1109/RTSS.2009.9</a>'
  apa: 'Henzinger, T. A., Kirsch, C., Marques, E., &#38; Sokolova, A. (2009). Distributed,
    modular HTL (pp. 171–180). Presented at the RTSS: Real-Time Systems Symposium,
    Washington, DC, United States: IEEE. <a href="https://doi.org/10.1109/RTSS.2009.9">https://doi.org/10.1109/RTSS.2009.9</a>'
  chicago: Henzinger, Thomas A, Christoph Kirsch, Eduardo Marques, and Ana Sokolova.
    “Distributed, Modular HTL,” 171–80. IEEE, 2009. <a href="https://doi.org/10.1109/RTSS.2009.9">https://doi.org/10.1109/RTSS.2009.9</a>.
  ieee: 'T. A. Henzinger, C. Kirsch, E. Marques, and A. Sokolova, “Distributed, modular
    HTL,” presented at the RTSS: Real-Time Systems Symposium, Washington, DC, United
    States, 2009, pp. 171–180.'
  ista: 'Henzinger TA, Kirsch C, Marques E, Sokolova A. 2009. Distributed, modular
    HTL. RTSS: Real-Time Systems Symposium, 171–180.'
  mla: Henzinger, Thomas A., et al. <i>Distributed, Modular HTL</i>. IEEE, 2009, pp.
    171–80, doi:<a href="https://doi.org/10.1109/RTSS.2009.9">10.1109/RTSS.2009.9</a>.
  short: T.A. Henzinger, C. Kirsch, E. Marques, A. Sokolova, in:, IEEE, 2009, pp.
    171–180.
conference:
  end_date: 2009-12-04
  location: Washington, DC, United States
  name: 'RTSS: Real-Time Systems Symposium'
  start_date: 2009-12-01
date_created: 2018-12-11T12:05:28Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T07:52:36Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1109/RTSS.2009.9
ec_funded: 1
file:
- access_level: open_access
  checksum: b2b15a5ef71eb50d62eaa5aea7efd8c4
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:07:56Z
  date_updated: 2020-07-14T12:46:17Z
  file_id: '4655'
  file_name: IST-2012-65-v1+1_Distributed_modular_Htl.pdf
  file_size: 526458
  relation: main_file
file_date_updated: 2020-07-14T12:46:17Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 171 - 180
project:
- _id: 25F1337C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '214373'
  name: Design for Embedded Systems
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '215543'
  name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: IEEE
publist_id: '2346'
pubrep_id: '65'
quality_controlled: '1'
status: public
title: Distributed, modular HTL
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2009'
...
---
_id: '3870'
abstract:
- lang: eng
  text: Games on graphs with omega-regular objectives provide a model for the control
    and synthesis of reactive systems. Every omega-regular objective can be decomposed
    into a safety part and a liveness part. The liveness part ensures that something
    good happens “eventually.” Two main strengths of the classical, infinite-limit
    formulation of liveness are robustness (independence from the granularity of transitions)
    and simplicity (abstraction of complicated time bounds). However, the classical
    liveness formulation suffers from the drawback that the time until something good
    happens may be unbounded. A stronger formulation of liveness, so-called finitary
    liveness, overcomes this drawback, while still retaining robustness and simplicity.
    Finitary liveness requires that there exists an unknown, fixed bound b such that
    something good happens within b transitions. While for one-shot liveness (reachability)
    objectives, classical and finitary liveness coincide, for repeated liveness (Buchi)
    objectives, the finitary formulation is strictly stronger. In this work we study
    games with finitary parity and Streett objectives. We prove the determinacy of
    these games, present algorithms for solving these games, and characterize the
    memory requirements of winning strategies. We show that finitary parity games
    can be solved in polynomial time, which is not known for infinitary parity games.
    For finitary Streett games, we give an EXPTIME algorithm and show that the problem
    is NP-hard. Our algorithms can be used, for example, for synthesizing controllers
    that do not let the response time of a system increase without bound.
acknowledgement: "This research was supported in part by the AFOSR MURI grant F49620-00-1-0327,
  the NSF grants CCR-0132780, CNS-0720884, and CCR- 225610, by the Swiss National
  Science Foundation, by the COMBEST project of the European Union, and EU-TMR network
  Games.\r\nWe thank anonymous reviewers for useful comments."
article_number: '1'
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Florian
  full_name: Horn, Florian
  id: 37327ACE-F248-11E8-B48F-1D18A9856A87
  last_name: Horn
citation:
  ama: Chatterjee K, Henzinger TA, Horn F. Finitary winning in omega-regular games.
    <i>ACM Transactions on Computational Logic (TOCL)</i>. 2009;11(1). doi:<a href="https://doi.org/10.1145/1614431.1614432">10.1145/1614431.1614432</a>
  apa: Chatterjee, K., Henzinger, T. A., &#38; Horn, F. (2009). Finitary winning in
    omega-regular games. <i>ACM Transactions on Computational Logic (TOCL)</i>. ACM.
    <a href="https://doi.org/10.1145/1614431.1614432">https://doi.org/10.1145/1614431.1614432</a>
  chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Florian Horn. “Finitary
    Winning in Omega-Regular Games.” <i>ACM Transactions on Computational Logic (TOCL)</i>.
    ACM, 2009. <a href="https://doi.org/10.1145/1614431.1614432">https://doi.org/10.1145/1614431.1614432</a>.
  ieee: K. Chatterjee, T. A. Henzinger, and F. Horn, “Finitary winning in omega-regular
    games,” <i>ACM Transactions on Computational Logic (TOCL)</i>, vol. 11, no. 1.
    ACM, 2009.
  ista: Chatterjee K, Henzinger TA, Horn F. 2009. Finitary winning in omega-regular
    games. ACM Transactions on Computational Logic (TOCL). 11(1), 1.
  mla: Chatterjee, Krishnendu, et al. “Finitary Winning in Omega-Regular Games.” <i>ACM
    Transactions on Computational Logic (TOCL)</i>, vol. 11, no. 1, 1, ACM, 2009,
    doi:<a href="https://doi.org/10.1145/1614431.1614432">10.1145/1614431.1614432</a>.
  short: K. Chatterjee, T.A. Henzinger, F. Horn, ACM Transactions on Computational
    Logic (TOCL) 11 (2009).
date_created: 2018-12-11T12:05:37Z
date_published: 2009-10-01T00:00:00Z
date_updated: 2021-01-12T07:52:50Z
day: '01'
ddc:
- '004'
department:
- _id: KrCh
doi: 10.1145/1614431.1614432
ec_funded: 1
file:
- access_level: open_access
  checksum: 139c4586d24f11e5da31fb3a0cf96ef4
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:08Z
  date_updated: 2020-07-14T12:46:20Z
  file_id: '5125'
  file_name: IST-2012-53-v1+1_Finitary_winning_in_omega-regular_games.pdf
  file_size: 180082
  relation: main_file
file_date_updated: 2020-07-14T12:46:20Z
has_accepted_license: '1'
intvolume: '        11'
issue: '1'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Submitted Version
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '215543'
  name: COMponent-Based Embedded Systems design Techniques
publication: ACM Transactions on Computational Logic (TOCL)
publication_status: published
publisher: ACM
publist_id: '2309'
pubrep_id: '53'
quality_controlled: '1'
scopus_import: 1
status: public
title: Finitary winning in omega-regular games
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2009'
...
---
_id: '3871'
abstract:
- lang: eng
  text: 'Nondeterministic weighted automata are finite automata with numerical weights
    oil transitions. They define quantitative languages 1, that assign to each word
    v; a real number L(w). The value of ail infinite word w is computed as the maximal
    value of all runs over w, and the value of a run as the supremum, limsup liminf,
    limit average, or discounted sum of the transition weights. We introduce probabilistic
    weighted antomata, in which the transitions are chosen in a randomized (rather
    than nondeterministic) fashion. Under almost-sure semantics (resp. positive semantics),
    the value of a word v) is the largest real v such that the runs over w have value
    at least v with probability I (resp. positive probability). We study the classical
    questions of automata theory for probabilistic weighted automata: emptiness and
    universality, expressiveness, and closure under various operations oil languages.
    For quantitative languages, emptiness university axe defined as whether the value
    of some (resp. every) word exceeds a given threshold. We prove some, of these
    questions to he decidable, and others undecidable. Regarding expressive power,
    we show that probabilities allow its to define a wide variety of new classes of
    quantitative languages except for discounted-sum automata, where probabilistic
    choice is no more expressive than nondeterminism. Finally we live ail almost complete
    picture of the closure of various classes of probabilistic weighted automata for
    the following, provide, is operations oil quantitative languages: maximum, sum.
    and numerical complement.'
acknowledgement: This research was supported in part by the Swiss National Science
  Foundation under the Indo-Swiss Joint Research Programme, by the European Network
  of Excellence on Embedded Systems Design (ArtistDesign), by the European projects
  Combest, Quasimodo, and Gasics, by the PAI program Moves funded by the Belgian Federal
  Government, and by the CFV (Federated Center in Verification ) funded by the F.R.S.-FNRS.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Laurent
  full_name: Doyen, Laurent
  last_name: Doyen
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Chatterjee K, Doyen L, Henzinger TA. Probabilistic weighted automata. In:
    Vol 5710. Springer; 2009:244-258. doi:<a href="https://doi.org/10.1007/978-3-642-04081-8_17">10.1007/978-3-642-04081-8_17</a>'
  apa: 'Chatterjee, K., Doyen, L., &#38; Henzinger, T. A. (2009). Probabilistic weighted
    automata (Vol. 5710, pp. 244–258). Presented at the CONCUR: Concurrency Theory,
    Bologna, Italy: Springer. <a href="https://doi.org/10.1007/978-3-642-04081-8_17">https://doi.org/10.1007/978-3-642-04081-8_17</a>'
  chicago: Chatterjee, Krishnendu, Laurent Doyen, and Thomas A Henzinger. “Probabilistic
    Weighted Automata,” 5710:244–58. Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-04081-8_17">https://doi.org/10.1007/978-3-642-04081-8_17</a>.
  ieee: 'K. Chatterjee, L. Doyen, and T. A. Henzinger, “Probabilistic weighted automata,”
    presented at the CONCUR: Concurrency Theory, Bologna, Italy, 2009, vol. 5710,
    pp. 244–258.'
  ista: 'Chatterjee K, Doyen L, Henzinger TA. 2009. Probabilistic weighted automata.
    CONCUR: Concurrency Theory, LNCS, vol. 5710, 244–258.'
  mla: Chatterjee, Krishnendu, et al. <i>Probabilistic Weighted Automata</i>. Vol.
    5710, Springer, 2009, pp. 244–58, doi:<a href="https://doi.org/10.1007/978-3-642-04081-8_17">10.1007/978-3-642-04081-8_17</a>.
  short: K. Chatterjee, L. Doyen, T.A. Henzinger, in:, Springer, 2009, pp. 244–258.
conference:
  end_date: 2009-09-04
  location: Bologna, Italy
  name: 'CONCUR: Concurrency Theory'
  start_date: 2009-09-01
date_created: 2018-12-11T12:05:37Z
date_published: 2009-09-01T00:00:00Z
date_updated: 2021-01-12T07:52:50Z
day: '01'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.1007/978-3-642-04081-8_17
ec_funded: 1
file:
- access_level: open_access
  checksum: af973ddbcf131b8810c6bff2c055ff56
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:46Z
  date_updated: 2020-07-14T12:46:20Z
  file_id: '4771'
  file_name: IST-2012-52-v1+1_Probabilistic_Weighted_Automata.pdf
  file_size: 200161
  relation: main_file
file_date_updated: 2020-07-14T12:46:20Z
has_accepted_license: '1'
intvolume: '      5710'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 244 - 258
project:
- _id: 25F1337C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '214373'
  name: Design for Embedded Systems
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '215543'
  name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: Springer
publist_id: '2304'
pubrep_id: '52'
quality_controlled: '1'
scopus_import: 1
status: public
title: Probabilistic weighted automata
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5710
year: '2009'
...
---
_id: '3946'
abstract:
- lang: eng
  text: We compare anti-parasite defences at the level of multicellular organisms
    and insect societies, and find that selection by parasites at these two organisational
    levels is often very similar and has created a number of parallel evolutionary
    solutions in the host's immune response. The defence mechanisms of both individuals
    and insect colonies start with border defences to prevent parasite intake and
    are followed by soma defences that prevent the establishment and spread of the
    parasite between the body's cells or the social insect workers. Lastly, germ line
    defences are employed to inhibit infection of the reproductive tissue of organisms
    or the reproductive individuals in colonies. We further find sophisticated self/non-self-recognition
    systems operating at both levels, which appear to be vital in maintaining the
    integrity of the body or colony as a reproductive entity. We then expand on the
    regulation of immune responses and end with a contemplation of how evolution may
    shape the different immune components, both within and between levels. The aim
    of this review is to highlight common evolutionary principles acting in disease
    defence at the level of both individual organisms and societies, thereby linking
    the fields of physiological and ecological immunology.
author:
- first_name: Sylvia
  full_name: Cremer, Sylvia
  id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
  last_name: Cremer
  orcid: 0000-0002-2193-3868
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
citation:
  ama: Cremer S, Sixt MK. Analogies in the evolution of individual and social immunity.
    <i>Philosophical Transactions of the Royal Society of London Series B, Biological
    Sciences</i>. 2009;364(1513):129-142. doi:<a href="https://doi.org/10.1098/rstb.2008.0166">10.1098/rstb.2008.0166</a>
  apa: Cremer, S., &#38; Sixt, M. K. (2009). Analogies in the evolution of individual
    and social immunity. <i>Philosophical Transactions of the Royal Society of London.
    Series B, Biological Sciences</i>. Royal Society, The. <a href="https://doi.org/10.1098/rstb.2008.0166">https://doi.org/10.1098/rstb.2008.0166</a>
  chicago: Cremer, Sylvia, and Michael K Sixt. “Analogies in the Evolution of Individual
    and Social Immunity.” <i>Philosophical Transactions of the Royal Society of London.
    Series B, Biological Sciences</i>. Royal Society, The, 2009. <a href="https://doi.org/10.1098/rstb.2008.0166">https://doi.org/10.1098/rstb.2008.0166</a>.
  ieee: S. Cremer and M. K. Sixt, “Analogies in the evolution of individual and social
    immunity,” <i>Philosophical Transactions of the Royal Society of London. Series
    B, Biological Sciences</i>, vol. 364, no. 1513. Royal Society, The, pp. 129–142,
    2009.
  ista: Cremer S, Sixt MK. 2009. Analogies in the evolution of individual and social
    immunity. Philosophical Transactions of the Royal Society of London. Series B,
    Biological Sciences. 364(1513), 129–142.
  mla: Cremer, Sylvia, and Michael K. Sixt. “Analogies in the Evolution of Individual
    and Social Immunity.” <i>Philosophical Transactions of the Royal Society of London.
    Series B, Biological Sciences</i>, vol. 364, no. 1513, Royal Society, The, 2009,
    pp. 129–42, doi:<a href="https://doi.org/10.1098/rstb.2008.0166">10.1098/rstb.2008.0166</a>.
  short: S. Cremer, M.K. Sixt, Philosophical Transactions of the Royal Society of
    London. Series B, Biological Sciences 364 (2009) 129–142.
date_created: 2018-12-11T12:06:02Z
date_published: 2009-01-12T00:00:00Z
date_updated: 2021-01-12T07:53:23Z
day: '12'
doi: 10.1098/rstb.2008.0166
extern: '1'
intvolume: '       364'
issue: '1513'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666697/
month: '01'
oa: 1
oa_version: None
page: 129 - 142
publication: Philosophical Transactions of the Royal Society of London. Series B,
  Biological Sciences
publication_status: published
publisher: Royal Society, The
publist_id: '2181'
status: public
title: Analogies in the evolution of individual and social immunity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 364
year: '2009'
...
---
_id: '3968'
abstract:
- lang: eng
  text: We describe an algorithm for segmenting three-dimensional medical imaging
    data modeled as a continuous function on a 3-manifold. It is related to watershed
    algorithms developed in image processing but is closer to its mathematical roots,
    which are Morse theory and homological algebra. It allows for the implicit treatment
    of an underlying mesh, thus combining the structural integrity of its mathematical
    foundations with the computational efficiency of image processing.
acknowledgement: This research was partially supported by Geomagic, Inc., and by the
  Defense Advanced Research Projects Agency (DARPA) under grants HR0011-05-1-0007
  and HR0011-05-1-0057.
alternative_title:
- LNCS
author:
- first_name: Herbert
  full_name: Edelsbrunner, Herbert
  id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
  last_name: Edelsbrunner
  orcid: 0000-0002-9823-6833
- first_name: John
  full_name: Harer, John
  last_name: Harer
citation:
  ama: 'Edelsbrunner H, Harer J. The persistent Morse complex segmentation of a 3-manifold.
    In: Vol 5903. Springer; 2009:36-50. doi:<a href="https://doi.org/10.1007/978-3-642-10470-1_4">10.1007/978-3-642-10470-1_4</a>'
  apa: 'Edelsbrunner, H., &#38; Harer, J. (2009). The persistent Morse complex segmentation
    of a 3-manifold (Vol. 5903, pp. 36–50). Presented at the 3DPH: Modelling the Physiological
    Human, Zermatt, Switzerland: Springer. <a href="https://doi.org/10.1007/978-3-642-10470-1_4">https://doi.org/10.1007/978-3-642-10470-1_4</a>'
  chicago: Edelsbrunner, Herbert, and John Harer. “The Persistent Morse Complex Segmentation
    of a 3-Manifold,” 5903:36–50. Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-10470-1_4">https://doi.org/10.1007/978-3-642-10470-1_4</a>.
  ieee: 'H. Edelsbrunner and J. Harer, “The persistent Morse complex segmentation
    of a 3-manifold,” presented at the 3DPH: Modelling the Physiological Human, Zermatt,
    Switzerland, 2009, vol. 5903, pp. 36–50.'
  ista: 'Edelsbrunner H, Harer J. 2009. The persistent Morse complex segmentation
    of a 3-manifold. 3DPH: Modelling the Physiological Human, LNCS, vol. 5903, 36–50.'
  mla: Edelsbrunner, Herbert, and John Harer. <i>The Persistent Morse Complex Segmentation
    of a 3-Manifold</i>. Vol. 5903, Springer, 2009, pp. 36–50, doi:<a href="https://doi.org/10.1007/978-3-642-10470-1_4">10.1007/978-3-642-10470-1_4</a>.
  short: H. Edelsbrunner, J. Harer, in:, Springer, 2009, pp. 36–50.
conference:
  end_date: 2009-12-02
  location: Zermatt, Switzerland
  name: '3DPH: Modelling the Physiological Human'
  start_date: 2009-11-29
date_created: 2018-12-11T12:06:10Z
date_published: 2009-11-17T00:00:00Z
date_updated: 2021-01-12T07:53:32Z
day: '17'
ddc:
- '000'
department:
- _id: HeEd
doi: 10.1007/978-3-642-10470-1_4
file:
- access_level: open_access
  checksum: 11fc85bcc19bab1f020e706a4b8a4660
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:33Z
  date_updated: 2020-07-14T12:46:21Z
  file_id: '4694'
  file_name: IST-2016-535-v1+1_2009-P-04-3ManifoldSegmentation.pdf
  file_size: 165090
  relation: main_file
file_date_updated: 2020-07-14T12:46:21Z
has_accepted_license: '1'
intvolume: '      5903'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Submitted Version
page: 36 - 50
publication_status: published
publisher: Springer
publist_id: '2160'
pubrep_id: '535'
quality_controlled: '1'
scopus_import: 1
status: public
title: The persistent Morse complex segmentation of a 3-manifold
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5903
year: '2009'
...
---
_id: '4136'
abstract:
- lang: eng
  text: 'Populations living in a spatially and temporally changing environment can
    adapt to the changing optimum and/or migrate toward favorable habitats. Here we
    extend previous analyses with a static optimum to allow the environment to vary
    in time as well as in space. The model follows both population dynamics and the
    trait mean under stabilizing selection, and the outcomes can be understood by
    comparing the loads due to genetic variance, dispersal, and temporal change. With
    fixed genetic variance, we obtain two regimes: (1) adaptation that is uniform
    along the environmental gradient and that responds to the moving optimum as expected
    for panmictic populations and when the spatial gradient is sufficiently steep,
    and (2) a population with limited range that adapts more slowly than the environmental
    optimum changes in both time and space; the population therefore becomes locally
    extinct and migrates toward suitable habitat. We also use a population‐genetic
    model with many loci to allow genetic variance to evolve, and we show that the
    only solution now has uniform adaptation.'
article_processing_charge: No
article_type: original
author:
- first_name: Jitka
  full_name: Polechova, Jitka
  id: 3BBFB084-F248-11E8-B48F-1D18A9856A87
  last_name: Polechova
  orcid: 0000-0003-0951-3112
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Glenn
  full_name: Marion, Glenn
  last_name: Marion
citation:
  ama: 'Polechova J, Barton NH, Marion G. Species’ range: Adaptation in space and
    time. <i>American Naturalist</i>. 2009;174(5):E186-E204. doi:<a href="https://doi.org/10.1086/605958">10.1086/605958</a>'
  apa: 'Polechova, J., Barton, N. H., &#38; Marion, G. (2009). Species’ range: Adaptation
    in space and time. <i>American Naturalist</i>. University of Chicago Press. <a
    href="https://doi.org/10.1086/605958">https://doi.org/10.1086/605958</a>'
  chicago: 'Polechova, Jitka, Nicholas H Barton, and Glenn Marion. “Species’ Range:
    Adaptation in Space and Time.” <i>American Naturalist</i>. University of Chicago
    Press, 2009. <a href="https://doi.org/10.1086/605958">https://doi.org/10.1086/605958</a>.'
  ieee: 'J. Polechova, N. H. Barton, and G. Marion, “Species’ range: Adaptation in
    space and time,” <i>American Naturalist</i>, vol. 174, no. 5. University of Chicago
    Press, pp. E186–E204, 2009.'
  ista: 'Polechova J, Barton NH, Marion G. 2009. Species’ range: Adaptation in space
    and time. American Naturalist. 174(5), E186–E204.'
  mla: 'Polechova, Jitka, et al. “Species’ Range: Adaptation in Space and Time.” <i>American
    Naturalist</i>, vol. 174, no. 5, University of Chicago Press, 2009, pp. E186–204,
    doi:<a href="https://doi.org/10.1086/605958">10.1086/605958</a>.'
  short: J. Polechova, N.H. Barton, G. Marion, American Naturalist 174 (2009) E186–E204.
date_created: 2018-12-11T12:07:09Z
date_published: 2009-11-05T00:00:00Z
date_updated: 2021-01-12T07:54:46Z
day: '05'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1086/605958
external_id:
  pmid:
  - ' 19788353'
intvolume: '       174'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.doi.org/10.1086/605958
month: '11'
oa: 1
oa_version: Published Version
page: E186 - E204
pmid: 1
publication: American Naturalist
publication_status: published
publisher: University of Chicago Press
publist_id: '1986'
pubrep_id: '552'
quality_controlled: '1'
related_material:
  link:
  - relation: erratum
    url: https://doi.org/10.1086/659642
scopus_import: 1
status: public
title: 'Species'' range: Adaptation in space and time'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 174
year: '2009'
...
---
_id: '4242'
abstract:
- lang: eng
  text: 'Felsenstein distinguished two ways by which selection can directly strengthen
    isolation. First, a modifier that strengthens prezygotic isolation can be favored
    everywhere. This fits with the traditional view of reinforcement as an adaptation
    to reduce deleterious hybridization by strengthening assortative mating. Second,
    selection can favor association between different incompatibilities, despite recombination.
    We generalize this “two allele” model to follow associations among any number
    of incompatibilities, which may include both assortment and hybrid inviability.
    Our key argument is that this process, of coupling between incompatibilities,
    may be quite different from the usual view of reinforcement: strong isolation
    can evolve through the coupling of any kind of incompatibility, whether prezygotic
    or postzygotic. Single locus incompatibilities become coupled because associations
    between them increase the variance in compatibility, which in turn increases mean
    fitness if there is positive epistasis. Multiple incompatibilities, each maintained
    by epistasis, can become coupled in the same way. In contrast, a single-locus
    incompatibility can become coupled with loci that reduce the viability of haploid
    hybrids because this reduces harmful recombination. We obtain simple approximations
    for the limits of tight linkage, and strong assortment, and show how assortment
    alleles can invade through associations with other components of reproductive
    isolation.'
acknowledgement: "This work was supported by a Royal Society/Wolfson Research Merit
  award, and by a grant from the Natural Environment Research Council.\r\nWe are very
  grateful for insightful comments from S. P. Otto, and for helpful suggestions from
  the referees and the Associate Editor, Maria Servedio."
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Maria
  full_name: De Cara, Maria
  last_name: De Cara
citation:
  ama: Barton NH, De Cara M. The evolution of strong reproductive isolation. <i>Evolution;
    International Journal of Organic Evolution</i>. 2009;63(5):1171-1190. doi:<a href="https://doi.org/10.1111/j.1558-5646.2009.00622.x">10.1111/j.1558-5646.2009.00622.x</a>
  apa: Barton, N. H., &#38; De Cara, M. (2009). The evolution of strong reproductive
    isolation. <i>Evolution; International Journal of Organic Evolution</i>. Wiley.
    <a href="https://doi.org/10.1111/j.1558-5646.2009.00622.x">https://doi.org/10.1111/j.1558-5646.2009.00622.x</a>
  chicago: Barton, Nicholas H, and Maria De Cara. “The Evolution of Strong Reproductive
    Isolation.” <i>Evolution; International Journal of Organic Evolution</i>. Wiley,
    2009. <a href="https://doi.org/10.1111/j.1558-5646.2009.00622.x">https://doi.org/10.1111/j.1558-5646.2009.00622.x</a>.
  ieee: N. H. Barton and M. De Cara, “The evolution of strong reproductive isolation,”
    <i>Evolution; International Journal of Organic Evolution</i>, vol. 63, no. 5.
    Wiley, pp. 1171–1190, 2009.
  ista: Barton NH, De Cara M. 2009. The evolution of strong reproductive isolation.
    Evolution; International Journal of Organic Evolution. 63(5), 1171–1190.
  mla: Barton, Nicholas H., and Maria De Cara. “The Evolution of Strong Reproductive
    Isolation.” <i>Evolution; International Journal of Organic Evolution</i>, vol.
    63, no. 5, Wiley, 2009, pp. 1171–90, doi:<a href="https://doi.org/10.1111/j.1558-5646.2009.00622.x">10.1111/j.1558-5646.2009.00622.x</a>.
  short: N.H. Barton, M. De Cara, Evolution; International Journal of Organic Evolution
    63 (2009) 1171–1190.
date_created: 2018-12-11T12:07:48Z
date_published: 2009-05-01T00:00:00Z
date_updated: 2021-01-12T07:55:33Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/j.1558-5646.2009.00622.x
file:
- access_level: open_access
  checksum: 1920d2e25ef335833764256c1a47bbfb
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:11:46Z
  date_updated: 2020-07-14T12:46:25Z
  file_id: '4903'
  file_name: IST-2016-551-v1+1_BartonDeCaraRevNew.pdf
  file_size: 720913
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  date_created: 2018-12-12T10:11:47Z
  date_updated: 2020-07-14T12:46:25Z
  file_id: '4904'
  file_name: IST-2016-551-v1+2_BartonDeCaraRevNewSI.pdf
  file_size: 290160
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file_date_updated: 2020-07-14T12:46:25Z
has_accepted_license: '1'
intvolume: '        63'
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 1171 - 1190
publication: Evolution; International Journal of Organic Evolution
publication_status: published
publisher: Wiley
publist_id: '1866'
pubrep_id: '551'
quality_controlled: '1'
scopus_import: 1
status: public
title: The evolution of strong reproductive isolation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 63
year: '2009'
...
---
_id: '4383'
abstract:
- lang: eng
  text: Pseudo-code descriptions of STMs assume sequentially consistent program execution
    and atomicity of high-level STM operations like read, write, and commit. These
    assumptions are often violated in realistic settings, as STM implementations run
    on relaxed memory models, with the atomicity of operations as provided by the
    hardware. This paper presents the first approach to verify STMs under relaxed
    memory models with atomicity of 32 bit loads and stores, and read-modify-write
    operations. We present RML, a new high-level language for expressing concurrent
    algorithms with a hardware-level atomicity of instructions, and whose semantics
    is parametrized by various relaxed memory models. We then present our tool, FOIL,
    which takes as input the RML description of an STM algorithm and the description
    of a memory model, and automatically determines the locations of fences, which
    if inserted, ensure the correctness of the STM algorithm under the given memory
    model. We use FOIL to verify DSTM, TL2, and McRT STM under the memory models of
    sequential consistency, total store order, partial store order, and relaxed memory
    order.
acknowledgement: This research was supported by the Swiss National Science Foundation.
alternative_title:
- LNCS
author:
- first_name: Rachid
  full_name: Guerraoui, Rachid
  last_name: Guerraoui
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Vasu
  full_name: Vasu Singh
  id: 4DAE2708-F248-11E8-B48F-1D18A9856A87
  last_name: Singh
citation:
  ama: 'Guerraoui R, Henzinger TA, Singh V. Software transactional memory on relaxed
    memory models. In: Vol 5643. Springer; 2009:321-336. doi:<a href="https://doi.org/10.1007/978-3-642-02658-4_26">10.1007/978-3-642-02658-4_26</a>'
  apa: 'Guerraoui, R., Henzinger, T. A., &#38; Singh, V. (2009). Software transactional
    memory on relaxed memory models (Vol. 5643, pp. 321–336). Presented at the CAV:
    Computer Aided Verification, Springer. <a href="https://doi.org/10.1007/978-3-642-02658-4_26">https://doi.org/10.1007/978-3-642-02658-4_26</a>'
  chicago: Guerraoui, Rachid, Thomas A Henzinger, and Vasu Singh. “Software Transactional
    Memory on Relaxed Memory Models,” 5643:321–36. Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-02658-4_26">https://doi.org/10.1007/978-3-642-02658-4_26</a>.
  ieee: 'R. Guerraoui, T. A. Henzinger, and V. Singh, “Software transactional memory
    on relaxed memory models,” presented at the CAV: Computer Aided Verification,
    2009, vol. 5643, pp. 321–336.'
  ista: 'Guerraoui R, Henzinger TA, Singh V. 2009. Software transactional memory on
    relaxed memory models. CAV: Computer Aided Verification, LNCS, vol. 5643, 321–336.'
  mla: Guerraoui, Rachid, et al. <i>Software Transactional Memory on Relaxed Memory
    Models</i>. Vol. 5643, Springer, 2009, pp. 321–36, doi:<a href="https://doi.org/10.1007/978-3-642-02658-4_26">10.1007/978-3-642-02658-4_26</a>.
  short: R. Guerraoui, T.A. Henzinger, V. Singh, in:, Springer, 2009, pp. 321–336.
conference:
  name: 'CAV: Computer Aided Verification'
date_created: 2018-12-11T12:08:34Z
date_published: 2009-06-19T00:00:00Z
date_updated: 2021-01-12T07:56:34Z
day: '19'
doi: 10.1007/978-3-642-02658-4_26
extern: 1
file:
- access_level: open_access
  checksum: df3c3e6306afd3f630a9146f91642f0a
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:14:50Z
  date_updated: 2020-07-14T12:46:28Z
  file_id: '5105'
  file_name: IST-2012-45-v1+1_Software_transactional_memory_on_relaxed_memory_models.pdf
  file_size: 265763
  relation: main_file
file_date_updated: 2020-07-14T12:46:28Z
intvolume: '      5643'
month: '06'
oa: 1
page: 321 - 336
publication_status: published
publisher: Springer
publist_id: '1074'
pubrep_id: '45'
quality_controlled: 0
status: public
title: Software transactional memory on relaxed memory models
type: conference
volume: 5643
year: '2009'
...
---
_id: '4403'
abstract:
- lang: eng
  text: For programs whose data variables range over boolean or finite domains, program
    verification is decidable, and this forms the basis of recent tools for software
    model checking. In this paper, we consider algorithmic verification of programs
    that use boolean variables, and in addition, access a single read-only array whose
    length is potentially unbounded, and whose elements range over a potentially unbounded
    data domain. We show that the reachability problem, while undecidable in general,
    is (1) Pspace-complete for programs in which the array-accessing for-loops are
    not nested, (2) decidable for a restricted class of programs with doubly-nested
    loops. The second result establishes connections to automata and logics defining
    languages over data words.
alternative_title:
- LNCS
author:
- first_name: Rajeev
  full_name: Alur, Rajeev
  last_name: Alur
- first_name: Pavol
  full_name: Cerny, Pavol
  id: 4DCBEFFE-F248-11E8-B48F-1D18A9856A87
  last_name: Cerny
- first_name: Scott
  full_name: Weinstein, Scott
  last_name: Weinstein
citation:
  ama: 'Alur R, Cerny P, Weinstein S. Algorithmic analysis of array-accessing programs.
    In: Vol 5771. Springer; 2009:86-101. doi:<a href="https://doi.org/10.1007/978-3-642-04027-6_9">10.1007/978-3-642-04027-6_9</a>'
  apa: 'Alur, R., Cerny, P., &#38; Weinstein, S. (2009). Algorithmic analysis of array-accessing
    programs (Vol. 5771, pp. 86–101). Presented at the CSL: Computer Science Logic,
    Coimbra, Portugal: Springer. <a href="https://doi.org/10.1007/978-3-642-04027-6_9">https://doi.org/10.1007/978-3-642-04027-6_9</a>'
  chicago: Alur, Rajeev, Pavol Cerny, and Scott Weinstein. “Algorithmic Analysis of
    Array-Accessing Programs,” 5771:86–101. Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-04027-6_9">https://doi.org/10.1007/978-3-642-04027-6_9</a>.
  ieee: 'R. Alur, P. Cerny, and S. Weinstein, “Algorithmic analysis of array-accessing
    programs,” presented at the CSL: Computer Science Logic, Coimbra, Portugal, 2009,
    vol. 5771, pp. 86–101.'
  ista: 'Alur R, Cerny P, Weinstein S. 2009. Algorithmic analysis of array-accessing
    programs. CSL: Computer Science Logic, LNCS, vol. 5771, 86–101.'
  mla: Alur, Rajeev, et al. <i>Algorithmic Analysis of Array-Accessing Programs</i>.
    Vol. 5771, Springer, 2009, pp. 86–101, doi:<a href="https://doi.org/10.1007/978-3-642-04027-6_9">10.1007/978-3-642-04027-6_9</a>.
  short: R. Alur, P. Cerny, S. Weinstein, in:, Springer, 2009, pp. 86–101.
conference:
  end_date: 2009-09-11
  location: Coimbra, Portugal
  name: 'CSL: Computer Science Logic'
  start_date: 2009-09-07
date_created: 2018-12-11T12:08:40Z
date_published: 2009-09-01T00:00:00Z
date_updated: 2023-02-23T11:06:20Z
day: '01'
doi: 10.1007/978-3-642-04027-6_9
extern: '1'
intvolume: '      5771'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://repository.upenn.edu/cis_reports/894/
month: '09'
oa: 1
oa_version: Submitted Version
page: 86 - 101
publication_status: published
publisher: Springer
publist_id: '1056'
quality_controlled: '1'
related_material:
  record:
  - id: '2967'
    relation: later_version
    status: public
status: public
title: Algorithmic analysis of array-accessing programs
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 5771
year: '2009'
...
---
_id: '4453'
abstract:
- lang: eng
  text: We present an on-the-fly abstraction technique for infinite-state continuous
    -time Markov chains. We consider Markov chains that are specified by a finite
    set of transition classes. Such models naturally represent biochemical reactions
    and therefore play an important role in the stochastic modeling of biological
    systems. We approximate the transient probability distributions at various time
    instances by solving a sequence of dynamically constructed abstract models, each
    depending on the previous one. Each abstract model is a finite Markov chain that
    represents the behavior of the original, infinite chain during a specific time
    interval. Our approach provides complete information about probability distributions,
    not just about individual parameters like the mean. The error of each abstraction
    can be computed, and the precision of the abstraction refined when desired. We
    implemented the algorithm and demonstrate its usefulness and efficiency on several
    case studies from systems biology.
acknowledgement: The research has been partially funded by the Swiss National Science
  Foundation under grant 205321-111840.
alternative_title:
- LNCS
author:
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Maria
  full_name: Maria Mateescu
  id: 3B43276C-F248-11E8-B48F-1D18A9856A87
  last_name: Mateescu
- first_name: Verena
  full_name: Wolf, Verena
  last_name: Wolf
citation:
  ama: 'Henzinger TA, Mateescu M, Wolf V. Sliding-window abstraction for infinite
    Markov chains. In: Vol 5643. Springer; 2009:337-352. doi:<a href="https://doi.org/10.1007/978-3-642-02658-4_27">10.1007/978-3-642-02658-4_27</a>'
  apa: 'Henzinger, T. A., Mateescu, M., &#38; Wolf, V. (2009). Sliding-window abstraction
    for infinite Markov chains (Vol. 5643, pp. 337–352). Presented at the CAV: Computer
    Aided Verification, Springer. <a href="https://doi.org/10.1007/978-3-642-02658-4_27">https://doi.org/10.1007/978-3-642-02658-4_27</a>'
  chicago: Henzinger, Thomas A, Maria Mateescu, and Verena Wolf. “Sliding-Window Abstraction
    for Infinite Markov Chains,” 5643:337–52. Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-02658-4_27">https://doi.org/10.1007/978-3-642-02658-4_27</a>.
  ieee: 'T. A. Henzinger, M. Mateescu, and V. Wolf, “Sliding-window abstraction for
    infinite Markov chains,” presented at the CAV: Computer Aided Verification, 2009,
    vol. 5643, pp. 337–352.'
  ista: 'Henzinger TA, Mateescu M, Wolf V. 2009. Sliding-window abstraction for infinite
    Markov chains. CAV: Computer Aided Verification, LNCS, vol. 5643, 337–352.'
  mla: Henzinger, Thomas A., et al. <i>Sliding-Window Abstraction for Infinite Markov
    Chains</i>. Vol. 5643, Springer, 2009, pp. 337–52, doi:<a href="https://doi.org/10.1007/978-3-642-02658-4_27">10.1007/978-3-642-02658-4_27</a>.
  short: T.A. Henzinger, M. Mateescu, V. Wolf, in:, Springer, 2009, pp. 337–352.
conference:
  name: 'CAV: Computer Aided Verification'
date_created: 2018-12-11T12:08:55Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T07:57:04Z
day: '01'
doi: 10.1007/978-3-642-02658-4_27
extern: 1
file:
- access_level: open_access
  checksum: 36b974111521ea534aae294166e93a63
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:12:20Z
  date_updated: 2020-07-14T12:46:30Z
  file_id: '4938'
  file_name: IST-2012-40-v1+1_Sliding-window_abstraction_for_infinite_markov_chains.pdf
  file_size: 804295
  relation: main_file
file_date_updated: 2020-07-14T12:46:30Z
intvolume: '      5643'
main_file_link:
- open_access: '0'
  url: http://pub.ist.ac.at/%7Etah/Publications/sliding-window_abstraction_for_infinite_markov_chains.pdf
month: '01'
oa: 1
page: 337 - 352
publication_status: published
publisher: Springer
publist_id: '278'
pubrep_id: '40'
quality_controlled: 0
status: public
title: Sliding-window abstraction for infinite Markov chains
type: conference
volume: 5643
year: '2009'
...
---
_id: '4542'
abstract:
- lang: eng
  text: "Weighted automata are finite automata with numerical weights on transitions.
    Nondeterministic weighted automata define quantitative languages L that assign
    to each word w a real number L(w) computed as the maximal value of all runs over
    w, and the value of a run r is a function of the sequence of weights that appear
    along r. There are several natural functions to consider such as Sup, LimSup,
    LimInf, limit average, and discounted sum of transition weights.\r\nWe introduce
    alternating weighted automata in which the transitions of the runs are chosen
    by two players in a turn-based fashion. Each word is assigned the maximal value
    of a run that the first player can enforce regardless of the choices made by the
    second player. We survey the results about closure properties, expressiveness,
    and decision problems for nondeterministic weighted automata, and we extend these
    results to alternating weighted automata.\r\nFor quantitative languages L 1 and
    L 2, we consider the pointwise operations max(L 1,L 2), min(L 1,L 2), 1 − L 1,
    and the sum L 1 + L 2. We establish the closure properties of all classes of alternating
    weighted automata with respect to these four operations.\r\nWe next compare the
    expressive power of the various classes of alternating and nondeterministic weighted
    automata over infinite words. In particular, for limit average and discounted
    sum, we show that alternation brings more expressive power than nondeterminism.\r\nFinally,
    we present decidability results and open questions for the quantitative extension
    of the classical decision problems in automata theory: emptiness, universality,
    language inclusion, and language equivalence."
acknowledgement: This research was supported in part by the Swiss National Science
  Foundation under the Indo-Swiss Joint Research Programme, by the European Network
  of Excellence on Embedded Systems Design (ArtistDesign), by the European Combest,
  Quasimodo, and Gasics projects, by the PAI program Moves funded by the Belgian Federal
  Government, and by the CFV (Federated Center in Verification) funded by the F.R.S.-FNRS.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Laurent
  full_name: Doyen, Laurent
  last_name: Doyen
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Chatterjee K, Doyen L, Henzinger TA. Alternating weighted automata. In: Vol
    5699. Springer; 2009:3-13. doi:<a href="https://doi.org/10.1007/978-3-642-03409-1_2">10.1007/978-3-642-03409-1_2</a>'
  apa: 'Chatterjee, K., Doyen, L., &#38; Henzinger, T. A. (2009). Alternating weighted
    automata (Vol. 5699, pp. 3–13). Presented at the FCT: Fundamentals of Computation
    Theory, Wroclaw, Poland: Springer. <a href="https://doi.org/10.1007/978-3-642-03409-1_2">https://doi.org/10.1007/978-3-642-03409-1_2</a>'
  chicago: Chatterjee, Krishnendu, Laurent Doyen, and Thomas A Henzinger. “Alternating
    Weighted Automata,” 5699:3–13. Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-03409-1_2">https://doi.org/10.1007/978-3-642-03409-1_2</a>.
  ieee: 'K. Chatterjee, L. Doyen, and T. A. Henzinger, “Alternating weighted automata,”
    presented at the FCT: Fundamentals of Computation Theory, Wroclaw, Poland, 2009,
    vol. 5699, pp. 3–13.'
  ista: 'Chatterjee K, Doyen L, Henzinger TA. 2009. Alternating weighted automata.
    FCT: Fundamentals of Computation Theory, LNCS, vol. 5699, 3–13.'
  mla: Chatterjee, Krishnendu, et al. <i>Alternating Weighted Automata</i>. Vol. 5699,
    Springer, 2009, pp. 3–13, doi:<a href="https://doi.org/10.1007/978-3-642-03409-1_2">10.1007/978-3-642-03409-1_2</a>.
  short: K. Chatterjee, L. Doyen, T.A. Henzinger, in:, Springer, 2009, pp. 3–13.
conference:
  end_date: 2009-09-04
  location: Wroclaw, Poland
  name: 'FCT: Fundamentals of Computation Theory'
  start_date: 2009-09-02
date_created: 2018-12-11T12:09:23Z
date_published: 2009-09-10T00:00:00Z
date_updated: 2021-01-12T07:59:34Z
day: '10'
ddc:
- '004'
department:
- _id: KrCh
doi: 10.1007/978-3-642-03409-1_2
ec_funded: 1
file:
- access_level: open_access
  checksum: e8f53abb63579de3f2bff58b2a1188e2
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:09Z
  date_updated: 2020-07-14T12:46:31Z
  file_id: '5126'
  file_name: IST-2012-39-v1+1_Alternating_Weighted_Automata.pdf
  file_size: 164428
  relation: main_file
file_date_updated: 2020-07-14T12:46:31Z
has_accepted_license: '1'
intvolume: '      5699'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Submitted Version
page: 3 - 13
project:
- _id: 25F1337C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '214373'
  name: Design for Embedded Systems
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '215543'
  name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: Springer
publist_id: '180'
pubrep_id: '39'
quality_controlled: '1'
scopus_import: 1
status: public
title: Alternating weighted automata
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5699
year: '2009'
...
---
_id: '4544'
abstract:
- lang: eng
  text: We consider concurrent games played on graphs. At every round of a game, each
    player simultaneously and independently selects a move; the moves jointly determine
    the transition to a successor state. Two basic objectives are the safety objective
    to stay forever in a given set of states, and its dual, the reachability objective
    to reach a given set of states. We present in this paper a strategy improvement
    algorithm for computing the value of a concurrent safety game, that is, the maximal
    probability with which player 1 can enforce the safety objective. The algorithm
    yields a sequence of player-1 strategies which ensure probabilities of winning
    that converge monotonically to the value of the safety game. Our result is significant
    because the strategy improvement algorithm provides, for the first time, a way
    to approximate the value of a concurrent safety game from below. Since a value
    iteration algorithm, or a strategy improvement algorithm for reachability games,
    can be used to approximate the same value from above, the combination of both
    algorithms yields a method for computing a converging sequence of upper and lower
    bounds for the values of concurrent reachability and safety games. Previous methods
    could approximate the values of these games only from one direction, and as no
    rates of convergence are known, they did not provide a practical way to solve
    these games.
author:
- first_name: Krishnendu
  full_name: Krishnendu Chatterjee
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Luca
  full_name: de Alfaro, Luca
  last_name: De Alfaro
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Chatterjee K, De Alfaro L, Henzinger TA. Termination criteria for solving
    concurrent safety and reachability games. In: SIAM; 2009:197-206. doi:<a href="https://doi.org/10.1137/1.9781611973068.23">10.1137/1.9781611973068.23</a>'
  apa: 'Chatterjee, K., De Alfaro, L., &#38; Henzinger, T. A. (2009). Termination
    criteria for solving concurrent safety and reachability games (pp. 197–206). Presented
    at the SODA: Symposium on Discrete Algorithms, SIAM. <a href="https://doi.org/10.1137/1.9781611973068.23">https://doi.org/10.1137/1.9781611973068.23</a>'
  chicago: Chatterjee, Krishnendu, Luca De Alfaro, and Thomas A Henzinger. “Termination
    Criteria for Solving Concurrent Safety and Reachability Games,” 197–206. SIAM,
    2009. <a href="https://doi.org/10.1137/1.9781611973068.23">https://doi.org/10.1137/1.9781611973068.23</a>.
  ieee: 'K. Chatterjee, L. De Alfaro, and T. A. Henzinger, “Termination criteria for
    solving concurrent safety and reachability games,” presented at the SODA: Symposium
    on Discrete Algorithms, 2009, pp. 197–206.'
  ista: 'Chatterjee K, De Alfaro L, Henzinger TA. 2009. Termination criteria for solving
    concurrent safety and reachability games. SODA: Symposium on Discrete Algorithms,
    197–206.'
  mla: Chatterjee, Krishnendu, et al. <i>Termination Criteria for Solving Concurrent
    Safety and Reachability Games</i>. SIAM, 2009, pp. 197–206, doi:<a href="https://doi.org/10.1137/1.9781611973068.23">10.1137/1.9781611973068.23</a>.
  short: K. Chatterjee, L. De Alfaro, T.A. Henzinger, in:, SIAM, 2009, pp. 197–206.
conference:
  name: 'SODA: Symposium on Discrete Algorithms'
date_created: 2018-12-11T12:09:24Z
date_published: 2009-01-01T00:00:00Z
date_updated: 2021-01-12T07:59:35Z
day: '01'
doi: 10.1137/1.9781611973068.23
extern: 1
file:
- access_level: open_access
  checksum: ce7dc1667502e26b23c07a767ac41ae6
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:08:03Z
  date_updated: 2020-07-14T12:46:31Z
  file_id: '4662'
  file_name: IST-2012-37-v1+1_Termination_criteria_for_solving_concurrent_safety_and_reachability_games.pdf
  file_size: 212369
  relation: main_file
file_date_updated: 2020-07-14T12:46:31Z
main_file_link:
- open_access: '1'
  url: https://repository.ist.ac.at/id/eprint/37
month: '01'
oa: 1
page: 197 - 206
publication_status: published
publisher: SIAM
publist_id: '176'
pubrep_id: '37'
quality_controlled: 0
status: public
title: Termination criteria for solving concurrent safety and reachability games
type: conference
year: '2009'
...
---
_id: '4545'
abstract:
- lang: eng
  text: 'A stochastic game is a two-player game played oil a graph, where in each
    state the successor is chosen either by One of the players, or according to a
    probability distribution. We Survey Stochastic games with limsup and liminf objectives.
    A real-valued re-ward is assigned to each state, and the value of all infinite
    path is the limsup (resp. liminf) of all rewards along the path. The value of
    a stochastic game is the maximal expected value of an infinite path that call
    he achieved by resolving the decisions of the first player. We present the complexity
    of computing values of Stochastic games and their subclasses, and the complexity,
    of optimal strategies in such games. '
acknowledgement: This research was supported in part by the Swiss National Science
  Foundation under the Indo-Swiss Joint Research Programme, by the European Network
  of Excellence on Embedded Systems Design (ArtistDesign), by the European projects
  COMBEST, Quasimodo, Gasics, by the PAI program Moves funded by the Belgian Federal
  Government, and by the CFV (Federated Center in Verification) funded by the F.R.S.-FNRS.
alternative_title:
- LNCS
author:
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Laurent
  full_name: Doyen, Laurent
  last_name: Doyen
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Chatterjee K, Doyen L, Henzinger TA. A survey of stochastic games with limsup
    and liminf objectives. In: Vol 5556. Springer; 2009:1-15. doi:<a href="https://doi.org/10.1007/978-3-642-02930-1_1">10.1007/978-3-642-02930-1_1</a>'
  apa: 'Chatterjee, K., Doyen, L., &#38; Henzinger, T. A. (2009). A survey of stochastic
    games with limsup and liminf objectives (Vol. 5556, pp. 1–15). Presented at the
    ICALP: Automata, Languages and Programming, Rhodos, Greece: Springer. <a href="https://doi.org/10.1007/978-3-642-02930-1_1">https://doi.org/10.1007/978-3-642-02930-1_1</a>'
  chicago: Chatterjee, Krishnendu, Laurent Doyen, and Thomas A Henzinger. “A Survey
    of Stochastic Games with Limsup and Liminf Objectives,” 5556:1–15. Springer, 2009.
    <a href="https://doi.org/10.1007/978-3-642-02930-1_1">https://doi.org/10.1007/978-3-642-02930-1_1</a>.
  ieee: 'K. Chatterjee, L. Doyen, and T. A. Henzinger, “A survey of stochastic games
    with limsup and liminf objectives,” presented at the ICALP: Automata, Languages
    and Programming, Rhodos, Greece, 2009, vol. 5556, pp. 1–15.'
  ista: 'Chatterjee K, Doyen L, Henzinger TA. 2009. A survey of stochastic games with
    limsup and liminf objectives. ICALP: Automata, Languages and Programming, LNCS,
    vol. 5556, 1–15.'
  mla: Chatterjee, Krishnendu, et al. <i>A Survey of Stochastic Games with Limsup
    and Liminf Objectives</i>. Vol. 5556, Springer, 2009, pp. 1–15, doi:<a href="https://doi.org/10.1007/978-3-642-02930-1_1">10.1007/978-3-642-02930-1_1</a>.
  short: K. Chatterjee, L. Doyen, T.A. Henzinger, in:, Springer, 2009, pp. 1–15.
conference:
  end_date: 2009-07-12
  location: Rhodos, Greece
  name: 'ICALP: Automata, Languages and Programming'
  start_date: 2009-07-05
date_created: 2018-12-11T12:09:24Z
date_published: 2009-06-24T00:00:00Z
date_updated: 2021-01-12T07:59:35Z
day: '24'
ddc:
- '000'
- '005'
department:
- _id: KrCh
doi: 10.1007/978-3-642-02930-1_1
ec_funded: 1
file:
- access_level: open_access
  checksum: dabb6d24428a000254c95493d9c492e6
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:13:11Z
  date_updated: 2020-07-14T12:46:31Z
  file_id: '4992'
  file_name: IST-2012-38-v1+1_A_survey_of_stochastic_games_with_limsup_and_liminf_objectives.pdf
  file_size: 187419
  relation: main_file
file_date_updated: 2020-07-14T12:46:31Z
has_accepted_license: '1'
intvolume: '      5556'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 1 - 15
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '215543'
  name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: Springer
publist_id: '177'
pubrep_id: '38'
quality_controlled: '1'
scopus_import: 1
status: public
title: A survey of stochastic games with limsup and liminf objectives
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5556
year: '2009'
...
---
_id: '4569'
abstract:
- lang: eng
  text: "Most specification languages express only qualitative constraints. However,
    among two implementations that satisfy a given specification, one may be preferred
    to another. For example, if a specification asks that every request is followed
    by a response, one may prefer an implementation that generates responses quickly
    but does not generate unnecessary responses. We use quantitative properties to
    measure the “goodness” of an implementation. Using games with corresponding quantitative
    objectives, we can synthesize “optimal” implementations, which are preferred among
    the set of possible implementations that satisfy a given specification.\r\nIn
    particular, we show how automata with lexicographic mean-payoff conditions can
    be used to express many interesting quantitative properties for reactive systems.
    In this framework, the synthesis of optimal implementations requires the solution
    of lexicographic mean-payoff games (for safety requirements), and the solution
    of games with both lexicographic mean-payoff and parity objectives (for liveness
    requirements). We present algorithms for solving both kinds of novel graph games."
acknowledgement: This research was supported by the Swiss National Science Foundation
  (Indo-Swiss Research Program and NCCR MICS) and the European Union projects COMBEST
  and COCONUT.
alternative_title:
- LNCS
arxiv: 1
author:
- first_name: Roderick
  full_name: Bloem, Roderick
  last_name: Bloem
- first_name: Krishnendu
  full_name: Chatterjee, Krishnendu
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Thomas A
  full_name: Henzinger, Thomas A
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
- first_name: Barbara
  full_name: Jobstmann, Barbara
  last_name: Jobstmann
citation:
  ama: 'Bloem R, Chatterjee K, Henzinger TA, Jobstmann B. Better quality in synthesis
    through quantitative objectives. In: Vol 5643. Springer; 2009:140-156. doi:<a
    href="https://doi.org/10.1007/978-3-642-02658-4_14">10.1007/978-3-642-02658-4_14</a>'
  apa: 'Bloem, R., Chatterjee, K., Henzinger, T. A., &#38; Jobstmann, B. (2009). Better
    quality in synthesis through quantitative objectives (Vol. 5643, pp. 140–156).
    Presented at the CAV: Computer Aided Verification, Grenoble, France: Springer.
    <a href="https://doi.org/10.1007/978-3-642-02658-4_14">https://doi.org/10.1007/978-3-642-02658-4_14</a>'
  chicago: Bloem, Roderick, Krishnendu Chatterjee, Thomas A Henzinger, and Barbara
    Jobstmann. “Better Quality in Synthesis through Quantitative Objectives,” 5643:140–56.
    Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-02658-4_14">https://doi.org/10.1007/978-3-642-02658-4_14</a>.
  ieee: 'R. Bloem, K. Chatterjee, T. A. Henzinger, and B. Jobstmann, “Better quality
    in synthesis through quantitative objectives,” presented at the CAV: Computer
    Aided Verification, Grenoble, France, 2009, vol. 5643, pp. 140–156.'
  ista: 'Bloem R, Chatterjee K, Henzinger TA, Jobstmann B. 2009. Better quality in
    synthesis through quantitative objectives. CAV: Computer Aided Verification, LNCS,
    vol. 5643, 140–156.'
  mla: Bloem, Roderick, et al. <i>Better Quality in Synthesis through Quantitative
    Objectives</i>. Vol. 5643, Springer, 2009, pp. 140–56, doi:<a href="https://doi.org/10.1007/978-3-642-02658-4_14">10.1007/978-3-642-02658-4_14</a>.
  short: R. Bloem, K. Chatterjee, T.A. Henzinger, B. Jobstmann, in:, Springer, 2009,
    pp. 140–156.
conference:
  end_date: 2009-07-02
  location: Grenoble, France
  name: 'CAV: Computer Aided Verification'
  start_date: 2009-06-26
date_created: 2018-12-11T12:09:31Z
date_published: 2009-06-19T00:00:00Z
date_updated: 2021-01-12T07:59:46Z
day: '19'
department:
- _id: KrCh
doi: 10.1007/978-3-642-02658-4_14
ec_funded: 1
external_id:
  arxiv:
  - '0904.2638'
intvolume: '      5643'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0904.2638
month: '06'
oa: 1
oa_version: Preprint
page: 140 - 156
project:
- _id: 25EFB36C-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '215543'
  name: COMponent-Based Embedded Systems design Techniques
publication_status: published
publisher: Springer
publist_id: '141'
quality_controlled: '1'
status: public
title: Better quality in synthesis through quantitative objectives
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5643
year: '2009'
...
---
_id: '4580'
abstract:
- lang: eng
  text: Alpaga is a solver for two-player parity games with imperfect information.
    Given the description of a game, it determines whether the first player can ensure
    to win and, if so, it constructs a winning strategy. The tool provides a symbolic
    implementation of a recent algorithm based on antichains.
alternative_title:
- LNCS
author:
- first_name: Dietmar
  full_name: Berwanger, Dietmar
  last_name: Berwanger
- first_name: Krishnendu
  full_name: Krishnendu Chatterjee
  id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
  last_name: Chatterjee
  orcid: 0000-0002-4561-241X
- first_name: Martin
  full_name: De Wulf, Martin
  last_name: De Wulf
- first_name: Laurent
  full_name: Doyen, Laurent
  last_name: Doyen
- first_name: Thomas A
  full_name: Thomas Henzinger
  id: 40876CD8-F248-11E8-B48F-1D18A9856A87
  last_name: Henzinger
  orcid: 0000−0002−2985−7724
citation:
  ama: 'Berwanger D, Chatterjee K, De Wulf M, Doyen L, Henzinger TA. Alpaga: A tool
    for solving parity games with imperfect information. In: Vol 5505. Springer; 2009:58-61.
    doi:<a href="https://doi.org/10.1007/978-3-642-00768-2_7">10.1007/978-3-642-00768-2_7</a>'
  apa: 'Berwanger, D., Chatterjee, K., De Wulf, M., Doyen, L., &#38; Henzinger, T.
    A. (2009). Alpaga: A tool for solving parity games with imperfect information
    (Vol. 5505, pp. 58–61). Presented at the TACAS: Tools and Algorithms for the Construction
    and Analysis of Systems, Springer. <a href="https://doi.org/10.1007/978-3-642-00768-2_7">https://doi.org/10.1007/978-3-642-00768-2_7</a>'
  chicago: 'Berwanger, Dietmar, Krishnendu Chatterjee, Martin De Wulf, Laurent Doyen,
    and Thomas A Henzinger. “Alpaga: A Tool for Solving Parity Games with Imperfect
    Information,” 5505:58–61. Springer, 2009. <a href="https://doi.org/10.1007/978-3-642-00768-2_7">https://doi.org/10.1007/978-3-642-00768-2_7</a>.'
  ieee: 'D. Berwanger, K. Chatterjee, M. De Wulf, L. Doyen, and T. A. Henzinger, “Alpaga:
    A tool for solving parity games with imperfect information,” presented at the
    TACAS: Tools and Algorithms for the Construction and Analysis of Systems, 2009,
    vol. 5505, pp. 58–61.'
  ista: 'Berwanger D, Chatterjee K, De Wulf M, Doyen L, Henzinger TA. 2009. Alpaga:
    A tool for solving parity games with imperfect information. TACAS: Tools and Algorithms
    for the Construction and Analysis of Systems, LNCS, vol. 5505, 58–61.'
  mla: 'Berwanger, Dietmar, et al. <i>Alpaga: A Tool for Solving Parity Games with
    Imperfect Information</i>. Vol. 5505, Springer, 2009, pp. 58–61, doi:<a href="https://doi.org/10.1007/978-3-642-00768-2_7">10.1007/978-3-642-00768-2_7</a>.'
  short: D. Berwanger, K. Chatterjee, M. De Wulf, L. Doyen, T.A. Henzinger, in:, Springer,
    2009, pp. 58–61.
conference:
  name: 'TACAS: Tools and Algorithms for the Construction and Analysis of Systems'
date_created: 2018-12-11T12:09:35Z
date_published: 2009-03-09T00:00:00Z
date_updated: 2021-01-12T07:59:52Z
day: '09'
doi: 10.1007/978-3-642-00768-2_7
extern: 1
file:
- access_level: open_access
  checksum: d52b55a10a47b3e3b0e016ea9bf85c41
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:15:45Z
  date_updated: 2020-07-14T12:46:32Z
  file_id: '5168'
  file_name: IST-2012-35-v1+1_Alpaga_-_A_tool_for_solving_parity_games_with_imperfect_information.pdf
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file_date_updated: 2020-07-14T12:46:32Z
intvolume: '      5505'
main_file_link:
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month: '03'
oa: 1
page: 58 - 61
publication_status: published
publisher: Springer
publist_id: '127'
pubrep_id: '35'
quality_controlled: 0
status: public
title: 'Alpaga: A tool for solving parity games with imperfect information'
type: conference
volume: 5505
year: '2009'
...
