---
_id: '2126'
abstract:
- lang: eng
  text: |
    Let K be an irreducible and reversible Markov kernel on a finite set X. We construct a metric W on the set of probability measures on X and show that with respect to this metric, the law of the continuous time Markov chain evolves as the gradient flow of the entropy. This result is a discrete counterpart of the Wasserstein gradient flow interpretation of the heat flow in Rn by Jordan, Kinderlehrer and Otto (1998). The metric W is similar to, but different from, the L2-Wasserstein metric, and is defined via a discrete variant of the Benamou–Brenier formula.
acknowledgement: Supported by Rubicon subsidy 680-50-0901 of the Netherlands Organisation
  for Scientific Research (NWO)
author:
- first_name: Jan
  full_name: Jan Maas
  id: 4C5696CE-F248-11E8-B48F-1D18A9856A87
  last_name: Maas
  orcid: 0000-0002-0845-1338
citation:
  ama: Maas J. Gradient flows of the entropy for finite Markov chains. <i>Journal
    of Functional Analysis</i>. 2011;261(8):2250-2292. doi:<a href="https://doi.org/10.1016/j.jfa.2011.06.009
    ">10.1016/j.jfa.2011.06.009 </a>
  apa: Maas, J. (2011). Gradient flows of the entropy for finite Markov chains. <i>Journal
    of Functional Analysis</i>. Academic Press. <a href="https://doi.org/10.1016/j.jfa.2011.06.009
    ">https://doi.org/10.1016/j.jfa.2011.06.009 </a>
  chicago: Maas, Jan. “Gradient Flows of the Entropy for Finite Markov Chains.” <i>Journal
    of Functional Analysis</i>. Academic Press, 2011. <a href="https://doi.org/10.1016/j.jfa.2011.06.009
    ">https://doi.org/10.1016/j.jfa.2011.06.009 </a>.
  ieee: J. Maas, “Gradient flows of the entropy for finite Markov chains,” <i>Journal
    of Functional Analysis</i>, vol. 261, no. 8. Academic Press, pp. 2250–2292, 2011.
  ista: Maas J. 2011. Gradient flows of the entropy for finite Markov chains. Journal
    of Functional Analysis. 261(8), 2250–2292.
  mla: Maas, Jan. “Gradient Flows of the Entropy for Finite Markov Chains.” <i>Journal
    of Functional Analysis</i>, vol. 261, no. 8, Academic Press, 2011, pp. 2250–92,
    doi:<a href="https://doi.org/10.1016/j.jfa.2011.06.009 ">10.1016/j.jfa.2011.06.009
    </a>.
  short: J. Maas, Journal of Functional Analysis 261 (2011) 2250–2292.
date_created: 2018-12-11T11:55:51Z
date_published: 2011-03-04T00:00:00Z
date_updated: 2021-01-12T06:55:28Z
day: '04'
doi: '10.1016/j.jfa.2011.06.009 '
extern: 1
intvolume: '       261'
issue: '8'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1102.5238
month: '03'
oa: 1
page: 2250 - 2292
publication: Journal of Functional Analysis
publication_status: published
publisher: Academic Press
publist_id: '4909'
quality_controlled: 0
status: public
title: Gradient flows of the entropy for finite Markov chains
type: journal_article
volume: 261
year: '2011'
...
---
_id: '2138'
abstract:
- lang: eng
  text: A (diatomic) shape resonance is a metastable state of a pair of colliding
    atoms quasi-bound by the centrifugal barrier imposed by the angular momentum involved
    in the collision. The temporary trapping of the atoms' scattering wavefunction
    corresponds to an enhanced atom pair density at low interatomic separations. This
    leads to larger overlap of the wavefunctions involved in a molecule formation
    process such as photoassociation, rendering the process more efficient. However,
    for an ensemble of atoms, the atom pair density will only be enhanced if the energy
    of the resonance comes close to the temperature of the atomic ensemble. Herein
    we explore the possibility of controlling the energy of a shape resonance by shifting
    it toward the temperature of atoms confined in a trap. The shifts are imparted
    by the interaction of non-resonant light with the anisotropic polarizability of
    the atom pair, which affects both the centrifugal barrier and the pair's rotational
    and vibrational levels. We find that at laser intensities of up to 5×109 W/cm2
    the pair density is increased by one order of magnitude for 87Rb atoms at 100μK
    and by two orders of magnitude for 88Sr atoms at 20μK.
acknowledgement: Financial support from the Deutsche Forschungsgemeinschaft (Grant
  No. KO 2301/2), by the Spanish project FIS2008-02380 (MICINN) as well as the Grants
  FQM-2445 and FQM-4643 (Junta de Andaluc´ıa), Campus de Excelencia Internacional
  Proyecto GENIL CEB09-0010
author:
- first_name: Ruzin
  full_name: Ağanoğlu, Ruzin
  last_name: Ağanoğlu
- first_name: Mikhail
  full_name: Mikhail Lemeshko
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Břetislav
  full_name: Friedrich, Břetislav
  last_name: Friedrich
- first_name: Rosario
  full_name: González-Férez, Rosario
  last_name: González Férez
- first_name: Christiane
  full_name: Koch, Christiane P
  last_name: Koch
citation:
  ama: Ağanoğlu R, Lemeshko M, Friedrich B, González Férez R, Koch C. Controlling
    a diatomic shape resonance with non-resonant light. <i>Unknown</i>. 2011.
  apa: Ağanoğlu, R., Lemeshko, M., Friedrich, B., González Férez, R., &#38; Koch,
    C. (2011). Controlling a diatomic shape resonance with non-resonant light. <i>Unknown</i>.
    ArXiv.
  chicago: Ağanoğlu, Ruzin, Mikhail Lemeshko, Břetislav Friedrich, Rosario González
    Férez, and Christiane Koch. “Controlling a Diatomic Shape Resonance with Non-Resonant
    Light.” <i>Unknown</i>. ArXiv, 2011.
  ieee: R. Ağanoğlu, M. Lemeshko, B. Friedrich, R. González Férez, and C. Koch, “Controlling
    a diatomic shape resonance with non-resonant light,” <i>Unknown</i>. ArXiv, 2011.
  ista: Ağanoğlu R, Lemeshko M, Friedrich B, González Férez R, Koch C. 2011. Controlling
    a diatomic shape resonance with non-resonant light. Unknown, .
  mla: Ağanoğlu, Ruzin, et al. “Controlling a Diatomic Shape Resonance with Non-Resonant
    Light.” <i>Unknown</i>, ArXiv, 2011.
  short: R. Ağanoğlu, M. Lemeshko, B. Friedrich, R. González Férez, C. Koch, Unknown
    (2011).
date_created: 2018-12-11T11:55:55Z
date_published: 2011-05-04T00:00:00Z
date_updated: 2021-01-12T06:55:32Z
day: '04'
extern: 1
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1105.0761
month: '05'
oa: 1
publication: Unknown
publication_status: published
publisher: ArXiv
publist_id: '4886'
quality_controlled: 0
status: public
title: Controlling a diatomic shape resonance with non-resonant light
type: preprint
year: '2011'
...
---
_id: '2198'
abstract:
- lang: eng
  text: We show that dressing polar molecules with a far-off-resonant optical field
    leads to new types of intermolecular potentials, which undergo a crossover from
    the inverse power to oscillating behavior depending on the intermolecular distance,
    and whose parameters can be tuned by varying the laser intensity and wavelength.
    We present analytic expressions for the potential energy surfaces, thereby providing
    direct access to the parameters of an optical field required to design intermolecular
    interactions experimentally.
author:
- first_name: Mikhail
  full_name: Mikhail Lemeshko
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
citation:
  ama: Lemeshko M. Shaping interactions between polar molecules with far-off-resonant
    light. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. 2011;83(5).
    doi:<a href="https://doi.org/10.1103/PhysRevA.83.051402">10.1103/PhysRevA.83.051402</a>
  apa: Lemeshko, M. (2011). Shaping interactions between polar molecules with far-off-resonant
    light. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American
    Physical Society. <a href="https://doi.org/10.1103/PhysRevA.83.051402">https://doi.org/10.1103/PhysRevA.83.051402</a>
  chicago: Lemeshko, Mikhail. “Shaping Interactions between Polar Molecules with Far-off-Resonant
    Light.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. American
    Physical Society, 2011. <a href="https://doi.org/10.1103/PhysRevA.83.051402">https://doi.org/10.1103/PhysRevA.83.051402</a>.
  ieee: M. Lemeshko, “Shaping interactions between polar molecules with far-off-resonant
    light,” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol.
    83, no. 5. American Physical Society, 2011.
  ista: Lemeshko M. 2011. Shaping interactions between polar molecules with far-off-resonant
    light. Physical Review A - Atomic, Molecular, and Optical Physics. 83(5).
  mla: Lemeshko, Mikhail. “Shaping Interactions between Polar Molecules with Far-off-Resonant
    Light.” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol.
    83, no. 5, American Physical Society, 2011, doi:<a href="https://doi.org/10.1103/PhysRevA.83.051402">10.1103/PhysRevA.83.051402</a>.
  short: M. Lemeshko, Physical Review A - Atomic, Molecular, and Optical Physics 83
    (2011).
date_created: 2018-12-11T11:56:17Z
date_published: 2011-05-27T00:00:00Z
date_updated: 2021-01-12T06:55:55Z
day: '27'
doi: 10.1103/PhysRevA.83.051402
extern: 1
intvolume: '        83'
issue: '5'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1104.1046
month: '05'
oa: 1
publication: Physical Review A - Atomic, Molecular, and Optical Physics
publication_status: published
publisher: American Physical Society
publist_id: '4775'
quality_controlled: 0
status: public
title: Shaping interactions between polar molecules with far-off-resonant light
type: journal_article
volume: 83
year: '2011'
...
---
_id: '2199'
abstract:
- lang: eng
  text: By invoking supersymmetry, we found a condition under which the Stark-effect
    problem for a polar and polarizable molecule subject to nonresonant electric fields
    becomes exactly solvable for the family of stretched states. The analytic expressions
    for the wave function and eigenenergy and other expectation values allow one to
    readily reverse-engineer the problem of finding the values of the interaction
    parameters required for creating quantum states with preordained characteristics.
    The method also allows the construction of families of isospectral potentials,
    realizable with combined fields.
acknowledgement: 'ARO '
author:
- first_name: Mikhail
  full_name: Mikhail Lemeshko
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Mustafa
  full_name: Mustafa, Mustafa K
  last_name: Mustafa
- first_name: Sabre
  full_name: Kais, Sabre
  last_name: Kais
- first_name: Břetislav
  full_name: Friedrich, Břetislav
  last_name: Friedrich
citation:
  ama: Lemeshko M, Mustafa M, Kais S, Friedrich B. Supersymmetric factorization yields
    exact solutions to the molecular Stark-effect problem for &#38;quot;stretched&#38;quot;
    states. <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>. 2011;83(4).
    doi:<a href="https://doi.org/10.1103/PhysRevA.83.043415">10.1103/PhysRevA.83.043415</a>
  apa: Lemeshko, M., Mustafa, M., Kais, S., &#38; Friedrich, B. (2011). Supersymmetric
    factorization yields exact solutions to the molecular Stark-effect problem for
    &#38;quot;stretched&#38;quot; states. <i>Physical Review A - Atomic, Molecular,
    and Optical Physics</i>. American Physical Society. <a href="https://doi.org/10.1103/PhysRevA.83.043415">https://doi.org/10.1103/PhysRevA.83.043415</a>
  chicago: Lemeshko, Mikhail, Mustafa Mustafa, Sabre Kais, and Břetislav Friedrich.
    “Supersymmetric Factorization Yields Exact Solutions to the Molecular Stark-Effect
    Problem for &#38;quot;Stretched&#38;quot; States.” <i>Physical Review A - Atomic,
    Molecular, and Optical Physics</i>. American Physical Society, 2011. <a href="https://doi.org/10.1103/PhysRevA.83.043415">https://doi.org/10.1103/PhysRevA.83.043415</a>.
  ieee: M. Lemeshko, M. Mustafa, S. Kais, and B. Friedrich, “Supersymmetric factorization
    yields exact solutions to the molecular Stark-effect problem for &#38;quot;stretched&#38;quot;
    states,” <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol.
    83, no. 4. American Physical Society, 2011.
  ista: Lemeshko M, Mustafa M, Kais S, Friedrich B. 2011. Supersymmetric factorization
    yields exact solutions to the molecular Stark-effect problem for &#38;quot;stretched&#38;quot;
    states. Physical Review A - Atomic, Molecular, and Optical Physics. 83(4).
  mla: Lemeshko, Mikhail, et al. “Supersymmetric Factorization Yields Exact Solutions
    to the Molecular Stark-Effect Problem for &#38;quot;Stretched&#38;quot; States.”
    <i>Physical Review A - Atomic, Molecular, and Optical Physics</i>, vol. 83, no.
    4, American Physical Society, 2011, doi:<a href="https://doi.org/10.1103/PhysRevA.83.043415">10.1103/PhysRevA.83.043415</a>.
  short: M. Lemeshko, M. Mustafa, S. Kais, B. Friedrich, Physical Review A - Atomic,
    Molecular, and Optical Physics 83 (2011).
date_created: 2018-12-11T11:56:17Z
date_published: 2011-04-25T00:00:00Z
date_updated: 2021-01-12T06:55:56Z
day: '25'
doi: 10.1103/PhysRevA.83.043415
extern: 1
intvolume: '        83'
issue: '4'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1105.5262
month: '04'
oa: 1
publication: Physical Review A - Atomic, Molecular, and Optical Physics
publication_status: published
publisher: American Physical Society
publist_id: '4776'
quality_controlled: 0
status: public
title: Supersymmetric factorization yields exact solutions to the molecular Stark-effect
  problem for &quot;stretched&quot; states
type: journal_article
volume: 83
year: '2011'
...
---
_id: '2200'
abstract:
- lang: eng
  text: We made use of supersymmetric (SUSY) quantum mechanics to find the condition
    under which the Stark effect problem for a polar and polarizable closed-shell
    diatomic molecule subjected to collinear electrostatic and nonresonant radiative
    fields becomes exactly solvable. The condition Δω = ω2/4(m+1)2 connects values
    of the dimensionless parameters ω and Δω that characterize the strengths of the
    permanent and induced dipole interactions of the molecule with the respective
    fields. The exact solutions are obtained for the \J̃ = m, m; ω, Δω) family of
    'stretched' states. The field-free and strong-field limits of the combined-fields
    problem were found to exhibit supersymmetry and shape invariance, which is indeed
    the reason why they are analytically solvable. By making use of the analytic form
    of the \J̃ = m,m; ω, Δω) wavefunctions, we obtained simple formulae for the expectation
    values of the space-fixed electric dipole moment, the alignment cosine and the
    angular momentum squared, and derived a 'sum rule' that combines the above expectation
    values into a formula for the eigenenergy. The analytic expressions for the characteristics
    of the strongly oriented and aligned states provide direct access to the values
    of the interaction parameters required for creating such states in the laboratory.
acknowledgement: SK thanks the ARO for financial support
author:
- first_name: Mikhail
  full_name: Mikhail Lemeshko
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Mustafa
  full_name: Mustafa, Mustafa K
  last_name: Mustafa
- first_name: Sabre
  full_name: Kais, Sabre
  last_name: Kais
- first_name: Břetislav
  full_name: Friedrich, Břetislav
  last_name: Friedrich
citation:
  ama: Lemeshko M, Mustafa M, Kais S, Friedrich B. Supersymmetry identifies molecular
    Stark states whose eigenproperties can be obtained analytically. <i>New Journal
    of Physics</i>. 2011;13. doi:<a href="https://doi.org/10.1088/1367-2630/13/6/063036">10.1088/1367-2630/13/6/063036</a>
  apa: Lemeshko, M., Mustafa, M., Kais, S., &#38; Friedrich, B. (2011). Supersymmetry
    identifies molecular Stark states whose eigenproperties can be obtained analytically.
    <i>New Journal of Physics</i>. IOP Publishing Ltd. <a href="https://doi.org/10.1088/1367-2630/13/6/063036">https://doi.org/10.1088/1367-2630/13/6/063036</a>
  chicago: Lemeshko, Mikhail, Mustafa Mustafa, Sabre Kais, and Břetislav Friedrich.
    “Supersymmetry Identifies Molecular Stark States Whose Eigenproperties Can Be
    Obtained Analytically.” <i>New Journal of Physics</i>. IOP Publishing Ltd., 2011.
    <a href="https://doi.org/10.1088/1367-2630/13/6/063036">https://doi.org/10.1088/1367-2630/13/6/063036</a>.
  ieee: M. Lemeshko, M. Mustafa, S. Kais, and B. Friedrich, “Supersymmetry identifies
    molecular Stark states whose eigenproperties can be obtained analytically,” <i>New
    Journal of Physics</i>, vol. 13. IOP Publishing Ltd., 2011.
  ista: Lemeshko M, Mustafa M, Kais S, Friedrich B. 2011. Supersymmetry identifies
    molecular Stark states whose eigenproperties can be obtained analytically. New
    Journal of Physics. 13.
  mla: Lemeshko, Mikhail, et al. “Supersymmetry Identifies Molecular Stark States
    Whose Eigenproperties Can Be Obtained Analytically.” <i>New Journal of Physics</i>,
    vol. 13, IOP Publishing Ltd., 2011, doi:<a href="https://doi.org/10.1088/1367-2630/13/6/063036">10.1088/1367-2630/13/6/063036</a>.
  short: M. Lemeshko, M. Mustafa, S. Kais, B. Friedrich, New Journal of Physics 13
    (2011).
date_created: 2018-12-11T11:56:17Z
date_published: 2011-06-20T00:00:00Z
date_updated: 2021-01-12T06:55:57Z
day: '20'
doi: 10.1088/1367-2630/13/6/063036
extern: 1
intvolume: '        13'
main_file_link:
- open_access: '1'
  url: 'http://arxiv.org/abs/1106.4402 '
month: '06'
oa: 1
publication: New Journal of Physics
publication_status: published
publisher: IOP Publishing Ltd.
publist_id: '4774'
quality_controlled: 0
status: public
title: Supersymmetry identifies molecular Stark states whose eigenproperties can be
  obtained analytically
type: journal_article
volume: 13
year: '2011'
...
---
_id: '2320'
abstract:
- lang: eng
  text: The binding of polarons, or its absence, is an old and subtle topic. After
    defining the model we state some recent theorems of ours. First, the transition
    from many-body collapse to the existence of a thermodynamic limit for N polarons
    occurs precisely at U = 2α, where U is the electronic Coulomb repulsion and α
    is the polaron coupling constant. Second, if U is large enough, there is no multi-polaron
    binding of any kind. We also discuss the Pekar-Tomasevich approximation to the
    ground state energy, which is valid for large α. Finally, we derive exact results,
    not reported before, about the one-dimensional toy model introduced by E. P. Gross.
author:
- first_name: Rupert
  full_name: Frank, Rupert L
  last_name: Frank
- first_name: Élliott
  full_name: Lieb, Élliott H
  last_name: Lieb
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
- first_name: Lawrence
  full_name: Thomas, Lawrence E
  last_name: Thomas
citation:
  ama: 'Frank R, Lieb É, Seiringer R, Thomas L. Binding, stability, and non-binding
    of multi-polaron systems. In: World Scientific Publishing; 2011:21-32. doi:<a
    href="https://doi.org/10.1142/9789814350365_0002">10.1142/9789814350365_0002</a>'
  apa: 'Frank, R., Lieb, É., Seiringer, R., &#38; Thomas, L. (2011). Binding, stability,
    and non-binding of multi-polaron systems (pp. 21–32). Presented at the QMath:
    Mathematical Results in Quantum Physics, World Scientific Publishing. <a href="https://doi.org/10.1142/9789814350365_0002">https://doi.org/10.1142/9789814350365_0002</a>'
  chicago: Frank, Rupert, Élliott Lieb, Robert Seiringer, and Lawrence Thomas. “Binding,
    Stability, and Non-Binding of Multi-Polaron Systems,” 21–32. World Scientific
    Publishing, 2011. <a href="https://doi.org/10.1142/9789814350365_0002">https://doi.org/10.1142/9789814350365_0002</a>.
  ieee: 'R. Frank, É. Lieb, R. Seiringer, and L. Thomas, “Binding, stability, and
    non-binding of multi-polaron systems,” presented at the QMath: Mathematical Results
    in Quantum Physics, 2011, pp. 21–32.'
  ista: 'Frank R, Lieb É, Seiringer R, Thomas L. 2011. Binding, stability, and non-binding
    of multi-polaron systems. QMath: Mathematical Results in Quantum Physics, 21–32.'
  mla: Frank, Rupert, et al. <i>Binding, Stability, and Non-Binding of Multi-Polaron
    Systems</i>. World Scientific Publishing, 2011, pp. 21–32, doi:<a href="https://doi.org/10.1142/9789814350365_0002">10.1142/9789814350365_0002</a>.
  short: R. Frank, É. Lieb, R. Seiringer, L. Thomas, in:, World Scientific Publishing,
    2011, pp. 21–32.
conference:
  name: 'QMath: Mathematical Results in Quantum Physics'
date_created: 2018-12-11T11:56:58Z
date_published: 2011-05-26T00:00:00Z
date_updated: 2021-01-12T06:56:45Z
day: '26'
doi: 10.1142/9789814350365_0002
extern: 1
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1010.0737
month: '05'
oa: 1
page: 21 - 32
publication_status: published
publisher: World Scientific Publishing
publist_id: '4607'
quality_controlled: 0
status: public
title: Binding, stability, and non-binding of multi-polaron systems
type: conference
year: '2011'
...
---
_id: '2321'
abstract:
- lang: eng
  text: We derive a sharp bound on the location of non-positive eigenvalues of Schrödinger
    operators on the half-line with complex-valued potentials.
alternative_title:
- 'Operator Theory: Advances and Applications'
author:
- first_name: Rupert
  full_name: Frank, Rupert L
  last_name: Frank
- first_name: Ari
  full_name: Laptev, Ari
  last_name: Laptev
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: 'Frank R, Laptev A, Seiringer R.  A sharp bound on eigenvalues of Schrödinger
    operators on the halfline with complex-valued potentials. In: Vol 214. Springer;
    2011:39-44. doi:<a href="https://doi.org/10.1007/978-3-7643-9994-8_3">10.1007/978-3-7643-9994-8_3</a>'
  apa: 'Frank, R., Laptev, A., &#38; Seiringer, R. (2011).  A sharp bound on eigenvalues
    of Schrödinger operators on the halfline with complex-valued potentials (Vol.
    214, pp. 39–44). Presented at the OTAMP: Operator Theory, Analysis and Mathematical
    Physics, Springer. <a href="https://doi.org/10.1007/978-3-7643-9994-8_3">https://doi.org/10.1007/978-3-7643-9994-8_3</a>'
  chicago: Frank, Rupert, Ari Laptev, and Robert Seiringer. “ A Sharp Bound on Eigenvalues
    of Schrödinger Operators on the Halfline with Complex-Valued Potentials,” 214:39–44.
    Springer, 2011. <a href="https://doi.org/10.1007/978-3-7643-9994-8_3">https://doi.org/10.1007/978-3-7643-9994-8_3</a>.
  ieee: 'R. Frank, A. Laptev, and R. Seiringer, “ A sharp bound on eigenvalues of
    Schrödinger operators on the halfline with complex-valued potentials,” presented
    at the OTAMP: Operator Theory, Analysis and Mathematical Physics, 2011, vol. 214,
    pp. 39–44.'
  ista: 'Frank R, Laptev A, Seiringer R. 2011.  A sharp bound on eigenvalues of Schrödinger
    operators on the halfline with complex-valued potentials. OTAMP: Operator Theory,
    Analysis and Mathematical Physics, Operator Theory: Advances and Applications,
    vol. 214, 39–44.'
  mla: Frank, Rupert, et al. <i> A Sharp Bound on Eigenvalues of Schrödinger Operators
    on the Halfline with Complex-Valued Potentials</i>. Vol. 214, Springer, 2011,
    pp. 39–44, doi:<a href="https://doi.org/10.1007/978-3-7643-9994-8_3">10.1007/978-3-7643-9994-8_3</a>.
  short: R. Frank, A. Laptev, R. Seiringer, in:, Springer, 2011, pp. 39–44.
conference:
  name: 'OTAMP: Operator Theory, Analysis and Mathematical Physics'
date_created: 2018-12-11T11:56:59Z
date_published: 2011-03-31T00:00:00Z
date_updated: 2021-01-12T06:56:46Z
day: '31'
doi: 10.1007/978-3-7643-9994-8_3
extern: 1
intvolume: '       214'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/0903.2053
month: '03'
oa: 1
page: 39 - 44
publication_status: published
publisher: Springer
publist_id: '4606'
quality_controlled: 0
status: public
title: ' A sharp bound on eigenvalues of Schrödinger operators on the halfline with
  complex-valued potentials'
type: conference
volume: 214
year: '2011'
...
---
_id: '2390'
abstract:
- lang: eng
  text: 'We resolve several longstanding problems concerning the stability and the
    absence of multi-particle binding for N≥2 polarons. Fröhlich''s 1937 polaron model
    describes non-relativistic particles interacting with a scalar quantized field
    with coupling √α, and with each other by Coulomb repulsion of strength U. We prove
    the following: (i) While there is a known thermodynamic instability for U&lt;2α,
    stability of matter does hold for U&gt;2α, that is, the ground state energy per
    particle has a finite limit as N→∞. (ii) There is no binding of any kind if U
    exceeds a critical value that depends on α but not on N. The same results are
    shown to hold for the Pekar-Tomasevich model.'
author:
- first_name: Rupert
  full_name: Frank, Rupert L
  last_name: Frank
- first_name: Élliott
  full_name: Lieb, Élliott H
  last_name: Lieb
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
- first_name: Lawrence
  full_name: Thomas, Lawrence E
  last_name: Thomas
citation:
  ama: Frank R, Lieb É, Seiringer R, Thomas L. Stability and absence of binding for
    multi-polaron systems. <i>Publications Mathematiques de l Institut des Hautes
    Etudes Scientifiques</i>. 2011;113(1):39-67. doi:<a href="https://doi.org/10.1007/s10240-011-0031-5">10.1007/s10240-011-0031-5</a>
  apa: Frank, R., Lieb, É., Seiringer, R., &#38; Thomas, L. (2011). Stability and
    absence of binding for multi-polaron systems. <i>Publications Mathematiques de
    l Institut Des Hautes Etudes Scientifiques</i>. Springer. <a href="https://doi.org/10.1007/s10240-011-0031-5">https://doi.org/10.1007/s10240-011-0031-5</a>
  chicago: Frank, Rupert, Élliott Lieb, Robert Seiringer, and Lawrence Thomas. “Stability
    and Absence of Binding for Multi-Polaron Systems.” <i>Publications Mathematiques
    de l Institut Des Hautes Etudes Scientifiques</i>. Springer, 2011. <a href="https://doi.org/10.1007/s10240-011-0031-5">https://doi.org/10.1007/s10240-011-0031-5</a>.
  ieee: R. Frank, É. Lieb, R. Seiringer, and L. Thomas, “Stability and absence of
    binding for multi-polaron systems,” <i>Publications Mathematiques de l Institut
    des Hautes Etudes Scientifiques</i>, vol. 113, no. 1. Springer, pp. 39–67, 2011.
  ista: Frank R, Lieb É, Seiringer R, Thomas L. 2011. Stability and absence of binding
    for multi-polaron systems. Publications Mathematiques de l Institut des Hautes
    Etudes Scientifiques. 113(1), 39–67.
  mla: Frank, Rupert, et al. “Stability and Absence of Binding for Multi-Polaron Systems.”
    <i>Publications Mathematiques de l Institut Des Hautes Etudes Scientifiques</i>,
    vol. 113, no. 1, Springer, 2011, pp. 39–67, doi:<a href="https://doi.org/10.1007/s10240-011-0031-5">10.1007/s10240-011-0031-5</a>.
  short: R. Frank, É. Lieb, R. Seiringer, L. Thomas, Publications Mathematiques de
    l Institut Des Hautes Etudes Scientifiques 113 (2011) 39–67.
date_created: 2018-12-11T11:57:23Z
date_published: 2011-06-01T00:00:00Z
date_updated: 2021-01-12T06:57:12Z
day: '01'
doi: 10.1007/s10240-011-0031-5
extern: 1
intvolume: '       113'
issue: '1'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1004.4892
month: '06'
oa: 1
page: 39 - 67
publication: Publications Mathematiques de l Institut des Hautes Etudes Scientifiques
publication_status: published
publisher: Springer
publist_id: '4534'
quality_controlled: 0
status: public
title: Stability and absence of binding for multi-polaron systems
type: journal_article
volume: 113
year: '2011'
...
---
_id: '2391'
abstract:
- lang: eng
  text: The change in energy of an ideal Fermi gas when a local one-body potential
    is inserted into the system, or when the density is changed locally, are important
    quantities in condensed matter physics. We show that they can be rigorously bounded
    from below by a universal constant times the value given by the semiclassical
    approximation.
author:
- first_name: Rupert
  full_name: Frank, Rupert L
  last_name: Frank
- first_name: Mathieu
  full_name: Lewin, Mathieu
  last_name: Lewin
- first_name: Élliott
  full_name: Lieb, Élliott H
  last_name: Lieb
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Frank R, Lewin M, Lieb É, Seiringer R. Energy cost to make a hole in the fermi
    sea. <i>Physical Review Letters</i>. 2011;106(15). doi:<a href="https://doi.org/10.1103/PhysRevLett.106.150402">10.1103/PhysRevLett.106.150402</a>
  apa: Frank, R., Lewin, M., Lieb, É., &#38; Seiringer, R. (2011). Energy cost to
    make a hole in the fermi sea. <i>Physical Review Letters</i>. American Physical
    Society. <a href="https://doi.org/10.1103/PhysRevLett.106.150402">https://doi.org/10.1103/PhysRevLett.106.150402</a>
  chicago: Frank, Rupert, Mathieu Lewin, Élliott Lieb, and Robert Seiringer. “Energy
    Cost to Make a Hole in the Fermi Sea.” <i>Physical Review Letters</i>. American
    Physical Society, 2011. <a href="https://doi.org/10.1103/PhysRevLett.106.150402">https://doi.org/10.1103/PhysRevLett.106.150402</a>.
  ieee: R. Frank, M. Lewin, É. Lieb, and R. Seiringer, “Energy cost to make a hole
    in the fermi sea,” <i>Physical Review Letters</i>, vol. 106, no. 15. American
    Physical Society, 2011.
  ista: Frank R, Lewin M, Lieb É, Seiringer R. 2011. Energy cost to make a hole in
    the fermi sea. Physical Review Letters. 106(15).
  mla: Frank, Rupert, et al. “Energy Cost to Make a Hole in the Fermi Sea.” <i>Physical
    Review Letters</i>, vol. 106, no. 15, American Physical Society, 2011, doi:<a
    href="https://doi.org/10.1103/PhysRevLett.106.150402">10.1103/PhysRevLett.106.150402</a>.
  short: R. Frank, M. Lewin, É. Lieb, R. Seiringer, Physical Review Letters 106 (2011).
date_created: 2018-12-11T11:57:24Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T06:57:12Z
day: '01'
doi: 10.1103/PhysRevLett.106.150402
extern: 1
intvolume: '       106'
issue: '15'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1102.1414
month: '01'
oa: 1
publication: Physical Review Letters
publication_status: published
publisher: American Physical Society
publist_id: '4535'
quality_controlled: 0
status: public
title: Energy cost to make a hole in the fermi sea
type: journal_article
volume: 106
year: '2011'
...
---
_id: '2393'
abstract:
- lang: eng
  text: We investigate the low energy excitation spectrum of a Bose gas with weak,
    long range repulsive interactions. In particular, we prove that the Bogoliubov
    spectrum of elementary excitations with linear dispersion relation for small momentum
    becomes exact in the mean-field limit.
author:
- first_name: Robert
  full_name: Robert Seiringer
  id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
  last_name: Seiringer
  orcid: 0000-0002-6781-0521
citation:
  ama: Seiringer R. The excitation spectrum for weakly interacting Bosons. <i>Communications
    in Mathematical Physics</i>. 2011;306(2):565-578. doi:<a href="https://doi.org/10.1007/s00220-011-1261-6">10.1007/s00220-011-1261-6</a>
  apa: Seiringer, R. (2011). The excitation spectrum for weakly interacting Bosons.
    <i>Communications in Mathematical Physics</i>. Springer. <a href="https://doi.org/10.1007/s00220-011-1261-6">https://doi.org/10.1007/s00220-011-1261-6</a>
  chicago: Seiringer, Robert. “The Excitation Spectrum for Weakly Interacting Bosons.”
    <i>Communications in Mathematical Physics</i>. Springer, 2011. <a href="https://doi.org/10.1007/s00220-011-1261-6">https://doi.org/10.1007/s00220-011-1261-6</a>.
  ieee: R. Seiringer, “The excitation spectrum for weakly interacting Bosons,” <i>Communications
    in Mathematical Physics</i>, vol. 306, no. 2. Springer, pp. 565–578, 2011.
  ista: Seiringer R. 2011. The excitation spectrum for weakly interacting Bosons.
    Communications in Mathematical Physics. 306(2), 565–578.
  mla: Seiringer, Robert. “The Excitation Spectrum for Weakly Interacting Bosons.”
    <i>Communications in Mathematical Physics</i>, vol. 306, no. 2, Springer, 2011,
    pp. 565–78, doi:<a href="https://doi.org/10.1007/s00220-011-1261-6">10.1007/s00220-011-1261-6</a>.
  short: R. Seiringer, Communications in Mathematical Physics 306 (2011) 565–578.
date_created: 2018-12-11T11:57:24Z
date_published: 2011-09-01T00:00:00Z
date_updated: 2021-01-12T06:57:13Z
day: '01'
doi: 10.1007/s00220-011-1261-6
extern: 1
intvolume: '       306'
issue: '2'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1008.5349
month: '09'
oa: 1
page: 565 - 578
publication: Communications in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4533'
quality_controlled: 0
status: public
title: The excitation spectrum for weakly interacting Bosons
type: journal_article
volume: 306
year: '2011'
...
---
_id: '2454'
abstract:
- lang: eng
  text: Within a multicellular tissue cells may coordinately form a singular or multiple
    polar axes, but it is unclear whether a common mechanism governs different types
    of polar axis formation. The phosphorylation status of PIN proteins, which is
    directly affected by the PINOID (PID) protein kinase and the PP2A protein phosphatase,
    is known to regulate the apical-basal polarity of PIN localization in bipolar
    cells of roots and shoot apices. Here, we provide evidence that the phosphorylation
    status-mediated PIN polarity switch is widely used to modulate cellular processes
    in Arabidopsis including multipolar pavement cells (PC) with interdigitated lobes
    and indentations. The degree of PC interdigitation was greatly reduced either
    when the FYPP1 gene, which encodes a PP2A called phytochrome-associated serine/threonine
    protein phosphatase, was knocked out or when the PID gene was overexpressed (35S:PID).
    These genetic modifications caused PIN1 localization to switch from lobe to indentation
    regions. The PP2A and PID mediated switching of PIN1 localization is strikingly
    similar to their regulation of the apical-basal polarity switch of PIN proteins
    in other cells. Our findings suggest a common mechanism for the regulation of
    PIN1 polarity formation, a fundamental cellular process that is crucial for pattern
    formation both at the tissue/organ and cellular levels.
author:
- first_name: Hongjiang
  full_name: Hongjiang Li
  id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
  last_name: Li
  orcid: 0000-0001-5039-9660
- first_name: Deshu
  full_name: Lin, Deshu
  last_name: Lin
- first_name: Pankaj
  full_name: Dhonukshe, Pankaj B
  last_name: Dhonukshe
- first_name: Shingo
  full_name: Nagawa, Shingo
  last_name: Nagawa
- first_name: Dandan
  full_name: Chen, Dandan
  last_name: Chen
- first_name: Jirí
  full_name: Jirí Friml
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Ben
  full_name: Scheres, Ben
  last_name: Scheres
- first_name: Hongwei
  full_name: Guo, Hongwei
  last_name: Guo
- first_name: Zhenbiao
  full_name: Yang, Zhenbiao
  last_name: Yang
citation:
  ama: Li H, Lin D, Dhonukshe P, et al. Phosphorylation switch modulates the interdigitated
    pattern of PIN1 localization and cell expansion in Arabidopsis leaf epidermis.
    <i>Cell Research</i>. 2011;21(6):970-978. doi:<a href="https://doi.org/10.1038/cr.2011.49">10.1038/cr.2011.49</a>
  apa: Li, H., Lin, D., Dhonukshe, P., Nagawa, S., Chen, D., Friml, J., … Yang, Z.
    (2011). Phosphorylation switch modulates the interdigitated pattern of PIN1 localization
    and cell expansion in Arabidopsis leaf epidermis. <i>Cell Research</i>. Nature
    Publishing Group. <a href="https://doi.org/10.1038/cr.2011.49">https://doi.org/10.1038/cr.2011.49</a>
  chicago: Li, Hongjiang, Deshu Lin, Pankaj Dhonukshe, Shingo Nagawa, Dandan Chen,
    Jiří Friml, Ben Scheres, Hongwei Guo, and Zhenbiao Yang. “Phosphorylation Switch
    Modulates the Interdigitated Pattern of PIN1 Localization and Cell Expansion in
    Arabidopsis Leaf Epidermis.” <i>Cell Research</i>. Nature Publishing Group, 2011.
    <a href="https://doi.org/10.1038/cr.2011.49">https://doi.org/10.1038/cr.2011.49</a>.
  ieee: H. Li <i>et al.</i>, “Phosphorylation switch modulates the interdigitated
    pattern of PIN1 localization and cell expansion in Arabidopsis leaf epidermis,”
    <i>Cell Research</i>, vol. 21, no. 6. Nature Publishing Group, pp. 970–978, 2011.
  ista: Li H, Lin D, Dhonukshe P, Nagawa S, Chen D, Friml J, Scheres B, Guo H, Yang
    Z. 2011. Phosphorylation switch modulates the interdigitated pattern of PIN1 localization
    and cell expansion in Arabidopsis leaf epidermis. Cell Research. 21(6), 970–978.
  mla: Li, Hongjiang, et al. “Phosphorylation Switch Modulates the Interdigitated
    Pattern of PIN1 Localization and Cell Expansion in Arabidopsis Leaf Epidermis.”
    <i>Cell Research</i>, vol. 21, no. 6, Nature Publishing Group, 2011, pp. 970–78,
    doi:<a href="https://doi.org/10.1038/cr.2011.49">10.1038/cr.2011.49</a>.
  short: H. Li, D. Lin, P. Dhonukshe, S. Nagawa, D. Chen, J. Friml, B. Scheres, H.
    Guo, Z. Yang, Cell Research 21 (2011) 970–978.
date_created: 2018-12-11T11:57:45Z
date_published: 2011-06-01T00:00:00Z
date_updated: 2021-01-12T06:57:35Z
day: '01'
doi: 10.1038/cr.2011.49
extern: 1
intvolume: '        21'
issue: '6'
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3203702/
month: '06'
oa: 1
page: 970 - 978
publication: Cell Research
publication_status: published
publisher: Nature Publishing Group
publist_id: '4449'
quality_controlled: 0
status: public
title: Phosphorylation switch modulates the interdigitated pattern of PIN1 localization
  and cell expansion in Arabidopsis leaf epidermis
type: journal_article
volume: 21
year: '2011'
...
---
_id: '2961'
abstract:
- lang: eng
  text: |-
    Rapid research progress in genotyping techniques have allowed large genome-wide association studies. Existing methods often focus on determining associations between single loci and a specic phenotype. However, a particular phenotype is usually the result of complex relationships between multiple loci and the environment. In this paper, we describe a two-stage method for detecting epistasis by combining the traditionally used single-locus search with a search for multiway interactions. Our method is based on an extended version of Fisher's exact test. To
    perform this test, a Markov chain is constructed on the space of multidimensional contingency tables using the elements of a Markov basis as moves. We test our method on simulated data and compare it to a two-stage logistic regression method and to a fully Bayesian method, showing that we are able to detect the interacting loci when other methods fail to do so. Finally, we apply our method to a genome-wide data set consisting of 685 dogs and identify epistasis associated with canine hair length for four pairs of single nucleotide polymorphisms (SNPs).
acknowledgement: Anna-Sapfo Malaspinas is supported by a Janggen-Poehn Fellowship.
  Caroline Uhler is supported by an International Fulbright Science and Technology
  Fellowship.
author:
- first_name: Anna
  full_name: 'Malaspinas, Anna-Sapfo '
  last_name: Malaspinas
- first_name: Caroline
  full_name: Caroline Uhler
  id: 49ADD78E-F248-11E8-B48F-1D18A9856A87
  last_name: Uhler
  orcid: 0000-0002-7008-0216
citation:
  ama: Malaspinas A, Uhler C. Detecting epistasis via Markov bases. <i>Journal of
    Algebraic Statistics</i>. 2011;2(1):36-53. doi:<a href="http://dx.doi.org/10.18409/jas.v2i1.27">http://dx.doi.org/10.18409/jas.v2i1.27</a>
  apa: Malaspinas, A., &#38; Uhler, C. (2011). Detecting epistasis via Markov bases.
    <i>Journal of Algebraic Statistics</i>. Public Knowledge Project. <a href="http://dx.doi.org/10.18409/jas.v2i1.27">http://dx.doi.org/10.18409/jas.v2i1.27</a>
  chicago: Malaspinas, Anna, and Caroline Uhler. “Detecting Epistasis via Markov Bases.”
    <i>Journal of Algebraic Statistics</i>. Public Knowledge Project, 2011. <a href="http://dx.doi.org/10.18409/jas.v2i1.27">http://dx.doi.org/10.18409/jas.v2i1.27</a>.
  ieee: A. Malaspinas and C. Uhler, “Detecting epistasis via Markov bases,” <i>Journal
    of Algebraic Statistics</i>, vol. 2, no. 1. Public Knowledge Project, pp. 36–53,
    2011.
  ista: Malaspinas A, Uhler C. 2011. Detecting epistasis via Markov bases. Journal
    of Algebraic Statistics. 2(1), 36–53.
  mla: Malaspinas, Anna, and Caroline Uhler. “Detecting Epistasis via Markov Bases.”
    <i>Journal of Algebraic Statistics</i>, vol. 2, no. 1, Public Knowledge Project,
    2011, pp. 36–53, doi:<a href="http://dx.doi.org/10.18409/jas.v2i1.27">http://dx.doi.org/10.18409/jas.v2i1.27</a>.
  short: A. Malaspinas, C. Uhler, Journal of Algebraic Statistics 2 (2011) 36–53.
date_created: 2018-12-11T12:00:34Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T07:40:05Z
day: '01'
doi: http://dx.doi.org/10.18409/jas.v2i1.27
extern: 1
intvolume: '         2'
issue: '1'
main_file_link:
- open_access: '1'
  url: http://arxiv.org/abs/1006.4929
month: '01'
oa: 1
page: 36 - 53
publication: Journal of Algebraic Statistics
publication_status: published
publisher: Public Knowledge Project
publist_id: '3764'
quality_controlled: 0
status: public
title: Detecting epistasis via Markov bases
type: journal_article
volume: 2
year: '2011'
...
---
_id: '3091'
author:
- first_name: Michael
  full_name: Sauer, Michael
  last_name: Sauer
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Sauer M, Friml J. Fleeting hormone cues get stabilized for plant organogenesis.
    <i>Molecular Systems Biology</i>. 2011;7. doi:<a href="https://doi.org/10.1038/msb.2011.45">10.1038/msb.2011.45</a>
  apa: Sauer, M., &#38; Friml, J. (2011). Fleeting hormone cues get stabilized for
    plant organogenesis. <i>Molecular Systems Biology</i>. Nature Publishing Group.
    <a href="https://doi.org/10.1038/msb.2011.45">https://doi.org/10.1038/msb.2011.45</a>
  chicago: Sauer, Michael, and Jiří Friml. “Fleeting Hormone Cues Get Stabilized for
    Plant Organogenesis.” <i>Molecular Systems Biology</i>. Nature Publishing Group,
    2011. <a href="https://doi.org/10.1038/msb.2011.45">https://doi.org/10.1038/msb.2011.45</a>.
  ieee: M. Sauer and J. Friml, “Fleeting hormone cues get stabilized for plant organogenesis,”
    <i>Molecular Systems Biology</i>, vol. 7. Nature Publishing Group, 2011.
  ista: Sauer M, Friml J. 2011. Fleeting hormone cues get stabilized for plant organogenesis.
    Molecular Systems Biology. 7.
  mla: Sauer, Michael, and Jiří Friml. “Fleeting Hormone Cues Get Stabilized for Plant
    Organogenesis.” <i>Molecular Systems Biology</i>, vol. 7, Nature Publishing Group,
    2011, doi:<a href="https://doi.org/10.1038/msb.2011.45">10.1038/msb.2011.45</a>.
  short: M. Sauer, J. Friml, Molecular Systems Biology 7 (2011).
date_created: 2018-12-11T12:01:19Z
date_published: 2011-07-05T00:00:00Z
date_updated: 2021-01-12T07:41:00Z
day: '05'
doi: 10.1038/msb.2011.45
extern: '1'
external_id:
  pmid:
  - '21734646'
intvolume: '         7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3159970/
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Molecular Systems Biology
publication_status: published
publisher: Nature Publishing Group
publist_id: '3610'
quality_controlled: '1'
status: public
title: Fleeting hormone cues get stabilized for plant organogenesis
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2011'
...
---
_id: '3092'
abstract:
- lang: eng
  text: The phytohormone auxin is vital to plant growth and development. A unique
    property of auxin among all other plant hormones is its cell-to-cell polar transport
    that requires activity of polarly localized PIN-FORMED (PIN) auxin efflux transporters.
    Despite the substantial molecular insight into the cellular PIN polarization,
    the mechanistic understanding for developmentally and environmentally regulated
    PIN polarization is scarce. The long-standing belief that auxin modulates its
    own transport by means of a positive feedback mechanism has inspired both experimentalists
    and theoreticians for more than two decades. Recently, theoretical models for
    auxin-dependent patterning in plants include the feedback between auxin transport
    and the PIN protein localization. These computer models aid to assess the complexity
    of plant development by testing and predicting plausible scenarios for various
    developmental processes that occur in planta. Although the majority of these models
    rely on purely heuristic principles, the most recent mechanistic models tentatively
    integrate biologically testable components into known cellular processes that
    underlie the PIN polarity regulation. The existing and emerging computational
    approaches to describe PIN polarization are presented and discussed in the light
    of recent experimental data on the PIN polar targeting.
author:
- first_name: Krzysztof T
  full_name: Wabnik, Krzysztof T
  id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
  last_name: Wabnik
  orcid: 0000-0001-7263-0560
- first_name: Willy
  full_name: Govaerts, Willy
  last_name: Govaerts
- first_name: Jirí
  full_name: Friml, Jirí
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Jürgen
  full_name: Kleine Vehn, Jürgen
  last_name: Kleine Vehn
citation:
  ama: 'Wabnik KT, Govaerts W, Friml J, Kleine Vehn J. Feedback models for polarized
    auxin transport: An emerging trend. <i>Molecular BioSystems</i>. 2011;7(8):2352-2359.
    doi:<a href="https://doi.org/10.1039/c1mb05109a">10.1039/c1mb05109a</a>'
  apa: 'Wabnik, K. T., Govaerts, W., Friml, J., &#38; Kleine Vehn, J. (2011). Feedback
    models for polarized auxin transport: An emerging trend. <i>Molecular BioSystems</i>.
    Royal Society of Chemistry. <a href="https://doi.org/10.1039/c1mb05109a">https://doi.org/10.1039/c1mb05109a</a>'
  chicago: 'Wabnik, Krzysztof T, Willy Govaerts, Jiří Friml, and Jürgen Kleine Vehn.
    “Feedback Models for Polarized Auxin Transport: An Emerging Trend.” <i>Molecular
    BioSystems</i>. Royal Society of Chemistry, 2011. <a href="https://doi.org/10.1039/c1mb05109a">https://doi.org/10.1039/c1mb05109a</a>.'
  ieee: 'K. T. Wabnik, W. Govaerts, J. Friml, and J. Kleine Vehn, “Feedback models
    for polarized auxin transport: An emerging trend,” <i>Molecular BioSystems</i>,
    vol. 7, no. 8. Royal Society of Chemistry, pp. 2352–2359, 2011.'
  ista: 'Wabnik KT, Govaerts W, Friml J, Kleine Vehn J. 2011. Feedback models for
    polarized auxin transport: An emerging trend. Molecular BioSystems. 7(8), 2352–2359.'
  mla: 'Wabnik, Krzysztof T., et al. “Feedback Models for Polarized Auxin Transport:
    An Emerging Trend.” <i>Molecular BioSystems</i>, vol. 7, no. 8, Royal Society
    of Chemistry, 2011, pp. 2352–59, doi:<a href="https://doi.org/10.1039/c1mb05109a">10.1039/c1mb05109a</a>.'
  short: K.T. Wabnik, W. Govaerts, J. Friml, J. Kleine Vehn, Molecular BioSystems
    7 (2011) 2352–2359.
date_created: 2018-12-11T12:01:20Z
date_published: 2011-06-10T00:00:00Z
date_updated: 2021-01-12T07:41:00Z
day: '10'
doi: 10.1039/c1mb05109a
extern: '1'
external_id:
  pmid:
  - '21660355'
intvolume: '         7'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pubmed/21660355
month: '06'
oa: 1
oa_version: Published Version
page: 2352 - 2359
pmid: 1
publication: Molecular BioSystems
publication_status: published
publisher: Royal Society of Chemistry
publist_id: '3608'
quality_controlled: '1'
status: public
title: 'Feedback models for polarized auxin transport: An emerging trend'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2011'
...
---
_id: '3100'
abstract:
- lang: eng
  text: In multicellular organisms, morphogenesis relies on a strict coordination
    in time and space of cell proliferation and differentiation. In contrast to animals,
    plant development displays continuous organ formation and adaptive growth responses
    during their lifespan relying on a tight coordination of cell proliferation. How
    developmental signals interact with the plant cell-cycle machinery is largely
    unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic
    cyclins, and show how they contribute to the fine-tuning of local proliferation
    during plant development. Moreover, the timely repression of CYCA2;3 expression
    in newly formed guard cells is shown to require the stomatal transcription factors
    FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming
    and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s
    represents a critical mechanism to coordinate proliferation during plant development.
author:
- first_name: Steffen
  full_name: Vanneste, Steffen
  last_name: Vanneste
- first_name: Frederik
  full_name: Coppens, Frederik
  last_name: Coppens
- first_name: Eunkyoung
  full_name: Lee, EunKyoung
  last_name: Lee
- first_name: Tyler
  full_name: Donner, Tyler J
  last_name: Donner
- first_name: Zidian
  full_name: Xie, Zidian
  last_name: Xie
- first_name: Gert
  full_name: Van Isterdael, Gert
  last_name: Van Isterdael
- first_name: Stijn
  full_name: Dhondt, Stijn
  last_name: Dhondt
- first_name: Freya
  full_name: De Winter, Freya
  last_name: De Winter
- first_name: Bert
  full_name: De Rybel, Bert
  last_name: De Rybel
- first_name: Marnik
  full_name: Vuylsteke, Marnik
  last_name: Vuylsteke
- first_name: Lieven
  full_name: De Veylder, Lieven
  last_name: De Veylder
- first_name: Jirí
  full_name: Jirí Friml
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Dirk
  full_name: Inzé, Dirk
  last_name: Inzé
- first_name: Erich
  full_name: Grotewold, Erich
  last_name: Grotewold
- first_name: Enrico
  full_name: Scarpella, Enrico
  last_name: Scarpella
- first_name: Fred
  full_name: Sack, Fred
  last_name: Sack
- first_name: Gerrit
  full_name: Beemster, Gerrit T
  last_name: Beemster
- first_name: Tom
  full_name: Beeckman, Tom
  last_name: Beeckman
citation:
  ama: Vanneste S, Coppens F, Lee E, et al. Developmental regulation of CYCA2s contributes
    to tissue-specific proliferation in Arabidopsis . <i>EMBO Journal</i>. 2011;30(16):3430-3441.
    doi:<a href="https://doi.org/10.1038/emboj.2011.240">10.1038/emboj.2011.240</a>
  apa: Vanneste, S., Coppens, F., Lee, E., Donner, T., Xie, Z., Van Isterdael, G.,
    … Beeckman, T. (2011). Developmental regulation of CYCA2s contributes to tissue-specific
    proliferation in Arabidopsis . <i>EMBO Journal</i>. Wiley-Blackwell. <a href="https://doi.org/10.1038/emboj.2011.240">https://doi.org/10.1038/emboj.2011.240</a>
  chicago: Vanneste, Steffen, Frederik Coppens, Eunkyoung Lee, Tyler Donner, Zidian
    Xie, Gert Van Isterdael, Stijn Dhondt, et al. “Developmental Regulation of CYCA2s
    Contributes to Tissue-Specific Proliferation in Arabidopsis .” <i>EMBO Journal</i>.
    Wiley-Blackwell, 2011. <a href="https://doi.org/10.1038/emboj.2011.240">https://doi.org/10.1038/emboj.2011.240</a>.
  ieee: S. Vanneste <i>et al.</i>, “Developmental regulation of CYCA2s contributes
    to tissue-specific proliferation in Arabidopsis ,” <i>EMBO Journal</i>, vol. 30,
    no. 16. Wiley-Blackwell, pp. 3430–3441, 2011.
  ista: Vanneste S, Coppens F, Lee E, Donner T, Xie Z, Van Isterdael G, Dhondt S,
    De Winter F, De Rybel B, Vuylsteke M, De Veylder L, Friml J, Inzé D, Grotewold
    E, Scarpella E, Sack F, Beemster G, Beeckman T. 2011. Developmental regulation
    of CYCA2s contributes to tissue-specific proliferation in Arabidopsis . EMBO Journal.
    30(16), 3430–3441.
  mla: Vanneste, Steffen, et al. “Developmental Regulation of CYCA2s Contributes to
    Tissue-Specific Proliferation in Arabidopsis .” <i>EMBO Journal</i>, vol. 30,
    no. 16, Wiley-Blackwell, 2011, pp. 3430–41, doi:<a href="https://doi.org/10.1038/emboj.2011.240">10.1038/emboj.2011.240</a>.
  short: S. Vanneste, F. Coppens, E. Lee, T. Donner, Z. Xie, G. Van Isterdael, S.
    Dhondt, F. De Winter, B. De Rybel, M. Vuylsteke, L. De Veylder, J. Friml, D. Inzé,
    E. Grotewold, E. Scarpella, F. Sack, G. Beemster, T. Beeckman, EMBO Journal 30
    (2011) 3430–3441.
date_created: 2018-12-11T12:01:23Z
date_published: 2011-08-17T00:00:00Z
date_updated: 2021-01-12T07:41:04Z
day: '17'
doi: 10.1038/emboj.2011.240
extern: 1
intvolume: '        30'
issue: '16'
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160660/
month: '08'
oa: 1
page: 3430 - 3441
publication: EMBO Journal
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3600'
quality_controlled: 0
status: public
title: 'Developmental regulation of CYCA2s contributes to tissue-specific proliferation
  in Arabidopsis '
type: journal_article
volume: 30
year: '2011'
...
---
_id: '3101'
abstract:
- lang: eng
  text: Subcellular trafficking is required for a multitude of functions in eukaryotic
    cells. It involves regulation of cargo sorting, vesicle formation, trafficking
    and fusion processes at multiple levels. Adaptor protein (AP) complexes are key
    regulators of cargo sorting into vesicles in yeast and mammals but their existence
    and function in plants have not been demonstrated. Here we report the identification
    of the protein-affected trafficking 4 (pat4) mutant defective in the putative
    δ subunit of the AP-3 complex. pat4 and pat2, a mutant isolated from the same
    GFP imaging-based forward genetic screen that lacks a functional putative AP-3
    β, as well as dominant negative AP-3 μ transgenic lines display undistinguishable
    phenotypes characterized by largely normal morphology and development, but strong
    intracellular accumulation of membrane proteins in aberrant vacuolar structures.
    All mutants are defective in morphology and function of lytic and protein storage
    vacuoles (PSVs) but show normal sorting of reserve proteins to PSVs. Immunoprecipitation
    experiments and genetic studies revealed tight functional and physical associations
    of putative AP-3 β and AP-3 δ subunits. Furthermore, both proteins are closely
    linked with putative AP-3 μ and σ subunits and several components of the clathrin
    and dynamin machineries. Taken together, these results demonstrate that AP complexes,
    similar to those in other eukaryotes, exist in plants, and that AP-3 plays a specific
    role in the regulation of biogenesis and function of vacuoles in plant cells.
    © 2011 IBCB, SIBS, CAS All rights reserved
author:
- first_name: Marta
  full_name: Zwiewka, Marta
  last_name: Zwiewka
- first_name: Elena
  full_name: Feraru, Elena
  last_name: Feraru
- first_name: Barbara
  full_name: Möller, Barbara
  last_name: Möller
- first_name: Inhwan
  full_name: Hwang, Inhwan
  last_name: Hwang
- first_name: Mugurel
  full_name: Feraru, Mugurel I
  last_name: Feraru
- first_name: Jürgen
  full_name: Kleine-Vehn, Jürgen
  last_name: Kleine Vehn
- first_name: Dolf
  full_name: Weijers, Dolf
  last_name: Weijers
- first_name: Jirí
  full_name: Jirí Friml
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Zwiewka M, Feraru E, Möller B, et al. The AP 3 adaptor complex is required
    for vacuolar function in Arabidopsis. <i>Cell Research</i>. 2011;21(12):1711-1722.
    doi:<a href="https://doi.org/10.1038/cr.2011.99">10.1038/cr.2011.99</a>
  apa: Zwiewka, M., Feraru, E., Möller, B., Hwang, I., Feraru, M., Kleine Vehn, J.,
    … Friml, J. (2011). The AP 3 adaptor complex is required for vacuolar function
    in Arabidopsis. <i>Cell Research</i>. Nature Publishing Group. <a href="https://doi.org/10.1038/cr.2011.99">https://doi.org/10.1038/cr.2011.99</a>
  chicago: Zwiewka, Marta, Elena Feraru, Barbara Möller, Inhwan Hwang, Mugurel Feraru,
    Jürgen Kleine Vehn, Dolf Weijers, and Jiří Friml. “The AP 3 Adaptor Complex Is
    Required for Vacuolar Function in Arabidopsis.” <i>Cell Research</i>. Nature Publishing
    Group, 2011. <a href="https://doi.org/10.1038/cr.2011.99">https://doi.org/10.1038/cr.2011.99</a>.
  ieee: M. Zwiewka <i>et al.</i>, “The AP 3 adaptor complex is required for vacuolar
    function in Arabidopsis,” <i>Cell Research</i>, vol. 21, no. 12. Nature Publishing
    Group, pp. 1711–1722, 2011.
  ista: Zwiewka M, Feraru E, Möller B, Hwang I, Feraru M, Kleine Vehn J, Weijers D,
    Friml J. 2011. The AP 3 adaptor complex is required for vacuolar function in Arabidopsis.
    Cell Research. 21(12), 1711–1722.
  mla: Zwiewka, Marta, et al. “The AP 3 Adaptor Complex Is Required for Vacuolar Function
    in Arabidopsis.” <i>Cell Research</i>, vol. 21, no. 12, Nature Publishing Group,
    2011, pp. 1711–22, doi:<a href="https://doi.org/10.1038/cr.2011.99">10.1038/cr.2011.99</a>.
  short: M. Zwiewka, E. Feraru, B. Möller, I. Hwang, M. Feraru, J. Kleine Vehn, D.
    Weijers, J. Friml, Cell Research 21 (2011) 1711–1722.
date_created: 2018-12-11T12:01:23Z
date_published: 2011-01-01T00:00:00Z
date_updated: 2021-01-12T07:41:04Z
day: '01'
doi: 10.1038/cr.2011.99
extern: 1
intvolume: '        21'
issue: '12'
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3357998/
month: '01'
oa: 1
page: 1711 - 1722
publication: Cell Research
publication_status: published
publisher: Nature Publishing Group
publist_id: '3597'
quality_controlled: 0
status: public
title: The AP 3 adaptor complex is required for vacuolar function in Arabidopsis
type: journal_article
volume: 21
year: '2011'
...
---
_id: '3269'
abstract:
- lang: eng
  text: The unintentional scattering of light between neighboring surfaces in complex
    projection environments increases the brightness and decreases the contrast, disrupting
    the appearance of the desired imagery. To achieve satisfactory projection results,
    the inverse problem of global illumination must be solved to cancel this secondary
    scattering. In this paper, we propose a global illumination cancellation method
    that minimizes the perceptual difference between the desired imagery and the actual
    total illumination in the resulting physical environment. Using Gauss-Newton and
    active set methods, we design a fast solver for the bound constrained nonlinear
    least squares problem raised by the perceptual error metrics. Our solver is further
    accelerated with a CUDA implementation and multi-resolution method to achieve
    1–2 fps for problems with approximately 3000 variables. We demonstrate the global
    illumination cancellation algorithm with our multi-projector system. Results show
    that our method preserves the color fidelity of the desired imagery significantly
    better than previous methods.
article_processing_charge: No
article_type: original
author:
- first_name: Yu
  full_name: Sheng, Yu
  last_name: Sheng
- first_name: Barbara
  full_name: Cutler, Barbara
  last_name: Cutler
- first_name: Chao
  full_name: Chen, Chao
  id: 3E92416E-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Joshua
  full_name: Nasman, Joshua
  last_name: Nasman
citation:
  ama: Sheng Y, Cutler B, Chen C, Nasman J. Perceptual global illumination cancellation
    in complex projection environments. <i>Computer Graphics Forum</i>. 2011;30(4):1261-1268.
    doi:<a href="https://doi.org/10.1111/j.1467-8659.2011.01985.x">10.1111/j.1467-8659.2011.01985.x</a>
  apa: Sheng, Y., Cutler, B., Chen, C., &#38; Nasman, J. (2011). Perceptual global
    illumination cancellation in complex projection environments. <i>Computer Graphics
    Forum</i>. Wiley-Blackwell. <a href="https://doi.org/10.1111/j.1467-8659.2011.01985.x">https://doi.org/10.1111/j.1467-8659.2011.01985.x</a>
  chicago: Sheng, Yu, Barbara Cutler, Chao Chen, and Joshua Nasman. “Perceptual Global
    Illumination Cancellation in Complex Projection Environments.” <i>Computer Graphics
    Forum</i>. Wiley-Blackwell, 2011. <a href="https://doi.org/10.1111/j.1467-8659.2011.01985.x">https://doi.org/10.1111/j.1467-8659.2011.01985.x</a>.
  ieee: Y. Sheng, B. Cutler, C. Chen, and J. Nasman, “Perceptual global illumination
    cancellation in complex projection environments,” <i>Computer Graphics Forum</i>,
    vol. 30, no. 4. Wiley-Blackwell, pp. 1261–1268, 2011.
  ista: Sheng Y, Cutler B, Chen C, Nasman J. 2011. Perceptual global illumination
    cancellation in complex projection environments. Computer Graphics Forum. 30(4),
    1261–1268.
  mla: Sheng, Yu, et al. “Perceptual Global Illumination Cancellation in Complex Projection
    Environments.” <i>Computer Graphics Forum</i>, vol. 30, no. 4, Wiley-Blackwell,
    2011, pp. 1261–68, doi:<a href="https://doi.org/10.1111/j.1467-8659.2011.01985.x">10.1111/j.1467-8659.2011.01985.x</a>.
  short: Y. Sheng, B. Cutler, C. Chen, J. Nasman, Computer Graphics Forum 30 (2011)
    1261–1268.
date_created: 2018-12-11T12:02:22Z
date_published: 2011-07-19T00:00:00Z
date_updated: 2021-01-12T07:42:16Z
day: '19'
department:
- _id: HeEd
doi: 10.1111/j.1467-8659.2011.01985.x
intvolume: '        30'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.cs.cmu.edu/%7Eshengyu/download/egsr2011_paper.pdf
month: '07'
oa: 1
oa_version: Published Version
page: 1261 - 1268
publication: Computer Graphics Forum
publication_status: published
publisher: Wiley-Blackwell
publist_id: '3377'
quality_controlled: '1'
scopus_import: 1
status: public
title: Perceptual global illumination cancellation in complex projection environments
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2011'
...
---
_id: '3275'
abstract:
- lang: eng
  text: 'Chemokines organize immune cell trafficking by inducing either directed (tactic)
    or random (kinetic) migration and by activating integrins in order to support
    surface adhesion (haptic). Beyond that the same chemokines can establish clearly
    defined functional areas in secondary lymphoid organs. Until now it is unclear
    how chemokines can fulfill such diverse functions. One decisive prerequisite to
    explain these capacities is to know how chemokines are presented in tissue. In
    theory chemokines could occur either soluble or immobilized, and could be distributed
    either homogenously or as a concentration gradient. To dissect if and how the
    presenting mode of chemokines influences immune cells, I tested the response of
    dendritic cells (DCs) to differentially displayed chemokines. DCs are antigen
    presenting cells that reside in the periphery and migrate into draining lymph
    nodes (LNs) once exposed to inflammatory stimuli to activate naïve T cells. DCs
    are guided to and within the LN by the chemokine receptor CCR7, which has two
    ligands, the chemokines CCL19 and CCL21. Both CCR7 ligands are expressed by fibroblastic
    reticular cells in the LN, but differ in their ability to bind to heparan sulfate
    residues. CCL21 has a highly charged C-terminal extension, which mediates binding
    to anionic surfaces, whereas CCL19 is lacking such residues and likely distributes
    as a soluble molecule. This study shows that surface-bound CCL21 causes random,
    haptokinetic DC motility, which is confined to the chemokine coated area by insideout
    activation of β2 integrins that mediate cell binding to the surface. CCL19 on
    the other hand forms concentration gradients which trigger directional, chemotactic
    movement, but no surface adhesion. In addition DCs can actively manipulate this
    system by recruiting and activating serine proteases on their surfaces, which
    create - by proteolytically removing the adhesive C-terminus - a solubilized variant
    of CCL21 that functionally resembles CCL19. By generating a CCL21 concentration
    gradient DCs establish a positive feedback loop to recruit further DCs from the
    periphery to the CCL21 coated region. In addition DCs can sense chemotactic gradients
    as well as immobilized haptokinetic fields at the same time and integrate these
    signals. The result is chemotactically biased haptokinesis - directional migration
    confined to a chemokine coated track or area - which could explain the dynamic
    but spatially tightly controlled swarming leukocyte locomotion patterns that have
    been observed in lymphatic organs by intravital microscopists. The finding that
    DCs can approach soluble cues in a non-adhesive manner while they attach to surfaces
    coated with immobilized cues raises the question how these cells transmit intracellular
    forces to the environment, especially in the non-adherent migration mode. In order
    to migrate, cells have to generate and transmit force to the extracellular substrate.
    Force transmission is the prerequisite to procure an expansion of the leading
    edge and a forward motion of the whole cell body. In the current conceptions actin
    polymerization at the leading edge is coupled to extracellular ligands via the
    integrin family of transmembrane receptors, which allows the transmission of intracellular
    force. Against the paradigm of force transmission during migration, leukocytes,
    like DCs, are able to migrate in threedimensional environments without using integrin
    transmembrane receptors (Lämmermann et al., 2008). This reflects the biological
    function of leukocytes, as they can invade almost all tissues, whereby their migration
    has to be independent from the extracellular environment. How the cells can achieve
    this is unclear. For this study I examined DC migration in a defined threedimensional
    environment and highlighted actin-dynamics with the probe Lifeact-GFP. The result
    was that chemotactic DCs can switch between integrin-dependent and integrin- independent
    locomotion and can thereby adapt to the adhesive properties of their environment.
    If the cells are able to couple their actin cytoskeleton to the substrate, actin
    polymerization is entirely converted into protrusion. Without coupling the actin
    cortex undergoes slippage and retrograde actin flow can be observed. But retrograde
    actin flow can be completely compensated by higher actin polymerization rate keeping
    the migration velocity and the shape of the cells unaltered. Mesenchymal cells
    like fibroblast cannot balance the loss of adhesive interaction, cannot protrude
    into open space and, therefore, strictly depend on integrinmediated force coupling.
    This leukocyte specific phenomenon of “adaptive force transmission” endows these
    cells with the unique ability to transit and invade almost every type of tissue. '
acknowledgement: "I would like to express my sincere gratitude to the following people
  who made with their continuous support and encouragement this thesis possible: First,
  I want to thank Prof. Dr. Michael Sixt for his excellent supervision and mentoring,
  especially for the nice, relaxed working atmosphere, a lot of brilliant ideas and
  the freedom to work in my own way.\r\n\r\nProf. Dr. Reinhard Fässler for his constant
  support of the Sixt lab and for providing excellent working conditions. \r\n\r\nProf.
  Dr. Sanjiv Luther and Prof. Dr. Tobias Bollenbach for agreeing to be member of my
  thesis committee and to evaluate my work.\r\n\r\nDr. Walther Göhring, Carmen Schmitz,
  the Recombinant Protein Production core facility and the animal care takers for
  providing the “infrastructure” for this thesis. \r\n\r\nProf. Dr. Daniel Legler,
  Markus Bruckner and Dr. Julien Polleux for very fruitful collaborations and discussions.\r\n\r\nMy
  labmates for their help, a lot of discussions and to make the Sixt lab to a convenient
  place to work : Karin Hirsch, Tim Lämmeramnn, Holger Pflicke, Jörg Renkawitz, Michele
  Weber and Alexander Eichner All members of the Department of Molecular Medicine
  for their help. Especially I want to thank Sarah Schmidt, Karin Hirsch and Raphael
  Ruppert for their friendship, nice chats and their uncensored point of view. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Kathrin
  full_name: Schumann, Kathrin
  id: F44D762E-4F9D-11E9-B64C-9EB26CEFFB5F
  last_name: Schumann
citation:
  ama: Schumann K. The role of chemotactic gradients in dendritic cell migration.
    2011.
  apa: Schumann, K. (2011). <i>The role of chemotactic gradients in dendritic cell
    migration</i>. Institute of Science and Technology Austria.
  chicago: Schumann, Kathrin. “The Role of Chemotactic Gradients in Dendritic Cell
    Migration.” Institute of Science and Technology Austria, 2011.
  ieee: K. Schumann, “The role of chemotactic gradients in dendritic cell migration,”
    Institute of Science and Technology Austria, 2011.
  ista: Schumann K. 2011. The role of chemotactic gradients in dendritic cell migration.
    Institute of Science and Technology Austria.
  mla: Schumann, Kathrin. <i>The Role of Chemotactic Gradients in Dendritic Cell Migration</i>.
    Institute of Science and Technology Austria, 2011.
  short: K. Schumann, The Role of Chemotactic Gradients in Dendritic Cell Migration,
    Institute of Science and Technology Austria, 2011.
date_created: 2018-12-11T12:02:24Z
date_published: 2011-03-01T00:00:00Z
date_updated: 2023-09-07T11:31:48Z
day: '01'
ddc:
- '570'
- '579'
degree_awarded: PhD
department:
- _id: MiSi
file:
- access_level: closed
  checksum: e69eee6252660f0b694a2ea8923ddc72
  content_type: application/pdf
  creator: dernst
  date_created: 2019-03-26T08:12:21Z
  date_updated: 2020-07-14T12:46:06Z
  file_id: '6177'
  file_name: 2011_Thesis_Kathrin_Schumann.pdf
  file_size: 4487708
  relation: main_file
- access_level: open_access
  checksum: 71727d63f424b5b446f68f4b87ecadc0
  content_type: application/pdf
  creator: dernst
  date_created: 2021-02-22T11:24:30Z
  date_updated: 2021-02-22T11:24:30Z
  file_id: '9175'
  file_name: 2011_Thesis_Schumann_noS.pdf
  file_size: 4313127
  relation: main_file
  success: 1
file_date_updated: 2021-02-22T11:24:30Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '141'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publist_id: '3371'
pubrep_id: '11'
status: public
supervisor:
- first_name: Michael K
  full_name: Sixt, Michael K
  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
  last_name: Sixt
  orcid: 0000-0002-6620-9179
title: The role of chemotactic gradients in dendritic cell migration
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2011'
...
---
_id: '3276'
abstract:
- lang: eng
  text: 'We present an algorithm to identify individual neural spikes observed on
    high-density multi-electrode arrays (MEAs). Our method can distinguish large numbers
    of distinct neural units, even when spikes overlap, and accounts for intrinsic
    variability of spikes from each unit. As MEAs grow larger, it is important to
    find spike-identification methods that are scalable, that is, the computational
    cost of spike fitting should scale well with the number of units observed. Our
    algorithm accomplishes this goal, and is fast, because it exploits the spatial
    locality of each unit and the basic biophysics of extracellular signal propagation.
    Human interaction plays a key role in our method; but effort is minimized and
    streamlined via a graphical interface. We illustrate our method on data from guinea
    pig retinal ganglion cells and document its performance on simulated data consisting
    of spikes added to experimentally measured background noise. We present several
    tests demonstrating that the algorithm is highly accurate: it exhibits low error
    rates on fits to synthetic data, low refractory violation rates, good receptive
    field coverage, and consistency across users.'
acknowledgement: |+
  This work was supported by National Science Foundation (NSF) grants IBN-0344678, EF-0928048, National Institutes of Health (NIH) grant RO1 EY08124, NIH training grant T32-07035, and NIH training grant 5T90DA022763-04.

  Michael Berry and Olivier Marre have developed an algorithm similar to, but different from, ours (manuscript in preparation). We thank them for discussions of their work, and specifically thank Olivier Marre for suggesting to us that the most complete subtraction of a spike can be obtained by refitting the spike without a prior.

author:
- first_name: Jason
  full_name: Prentice, Jason S
  last_name: Prentice
- first_name: Jan
  full_name: Homann, Jan
  last_name: Homann
- first_name: Kristina
  full_name: Simmons, Kristina D
  last_name: Simmons
- first_name: Gasper
  full_name: Gasper Tkacik
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Vijay
  full_name: Balasubramanian, Vijay
  last_name: Balasubramanian
- first_name: Philip
  full_name: Nelson, Philip C
  last_name: Nelson
citation:
  ama: Prentice J, Homann J, Simmons K, Tkačik G, Balasubramanian V, Nelson P. Fast,
    scalable, Bayesian spike identification for multi-electrode arrays. <i>PLoS One</i>.
    2011;6(7). doi:<a href="https://doi.org/10.1371/journal.pone.0019884">10.1371/journal.pone.0019884</a>
  apa: Prentice, J., Homann, J., Simmons, K., Tkačik, G., Balasubramanian, V., &#38;
    Nelson, P. (2011). Fast, scalable, Bayesian spike identification for multi-electrode
    arrays. <i>PLoS One</i>. Public Library of Science. <a href="https://doi.org/10.1371/journal.pone.0019884">https://doi.org/10.1371/journal.pone.0019884</a>
  chicago: Prentice, Jason, Jan Homann, Kristina Simmons, Gašper Tkačik, Vijay Balasubramanian,
    and Philip Nelson. “Fast, Scalable, Bayesian Spike Identification for Multi-Electrode
    Arrays.” <i>PLoS One</i>. Public Library of Science, 2011. <a href="https://doi.org/10.1371/journal.pone.0019884">https://doi.org/10.1371/journal.pone.0019884</a>.
  ieee: J. Prentice, J. Homann, K. Simmons, G. Tkačik, V. Balasubramanian, and P.
    Nelson, “Fast, scalable, Bayesian spike identification for multi-electrode arrays,”
    <i>PLoS One</i>, vol. 6, no. 7. Public Library of Science, 2011.
  ista: Prentice J, Homann J, Simmons K, Tkačik G, Balasubramanian V, Nelson P. 2011.
    Fast, scalable, Bayesian spike identification for multi-electrode arrays. PLoS
    One. 6(7).
  mla: Prentice, Jason, et al. “Fast, Scalable, Bayesian Spike Identification for
    Multi-Electrode Arrays.” <i>PLoS One</i>, vol. 6, no. 7, Public Library of Science,
    2011, doi:<a href="https://doi.org/10.1371/journal.pone.0019884">10.1371/journal.pone.0019884</a>.
  short: J. Prentice, J. Homann, K. Simmons, G. Tkačik, V. Balasubramanian, P. Nelson,
    PLoS One 6 (2011).
date_created: 2018-12-11T12:02:24Z
date_published: 2011-07-20T00:00:00Z
date_updated: 2021-01-12T07:42:19Z
day: '20'
doi: 10.1371/journal.pone.0019884
extern: 1
file:
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file_date_updated: 2020-07-14T12:46:06Z
intvolume: '         6'
issue: '7'
license: https://creativecommons.org/licenses/by/4.0/
month: '07'
oa: 1
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '3370'
pubrep_id: '381'
quality_controlled: 0
status: public
title: Fast, scalable, Bayesian spike identification for multi-electrode arrays
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
volume: 6
year: '2011'
...
...
---
_id: '3288'
abstract:
- lang: eng
  text: 'The zonula adherens (ZA) of epithelial cells is a site of cell-cell adhesion
    where cellular forces are exerted and resisted. Increasing evidence indicates
    that E-cadherin adhesion molecules at the ZA serve to sense force applied on the
    junctions and coordinate cytoskeletal responses to those forces. Efforts to understand
    the role that cadherins play in mechanotransduction have been limited by the lack
    of assays to measure the impact of forces on the ZA. In this study we used 4D
    imaging of GFP-tagged E-cadherin to analyse the movement of the ZA. Junctions
    in confluent epithelial monolayers displayed prominent movements oriented orthogonal
    (perpendicular) to the ZA itself. Two components were identified in these movements:
    a relatively slow unidirectional (translational) component that could be readily
    fitted by least-squares regression analysis, upon which were superimposed more
    rapid oscillatory movements. Myosin IIB was a dominant factor responsible for
    driving the unilateral translational movements. In contrast, frequency spectrum
    analysis revealed that depletion of Myosin IIA increased the power of the oscillatory
    movements. This implies that Myosin IIA may serve to dampen oscillatory movements
    of the ZA. This extends our recent analysis of Myosin II at the ZA to demonstrate
    that Myosin IIA and Myosin IIB make distinct contributions to junctional movement
    at the ZA.'
acknowledgement: his work was funded by the National Health and Medical Research Council
  (NHMRC) of Australia. M.S. was an Erwin Schroedinger postdoctoral fellow of the
  Austrian Science Fund (FWF), S.K.W. is supported by a UQ International Research
  Tuition Award and Research Scholarship, S.M .by an ANZ Trustees PhD Scholarship.
  A.S.Y. is a Research Fellow of the NHMRC. Confocal imaging was performed at the
  Australian Cancer Research Foundation (ACRF) Cancer Biology Imaging Centre at the
  Institute for Molecular Bioscience, established with the generous support of the
  ACRF.
author:
- first_name: Michael
  full_name: Smutny, Michael
  id: 3FE6E4E8-F248-11E8-B48F-1D18A9856A87
  last_name: Smutny
  orcid: 0000-0002-5920-9090
- first_name: Selwin
  full_name: Wu, Selwin
  last_name: Wu
- first_name: Guillermo
  full_name: Gomez, Guillermo
  last_name: Gomez
- first_name: Sabine
  full_name: Mangold, Sabine
  last_name: Mangold
- first_name: Alpha
  full_name: Yap, Alpha
  last_name: Yap
- first_name: Nicholas
  full_name: Hamilton, Nicholas
  last_name: Hamilton
citation:
  ama: Smutny M, Wu S, Gomez G, Mangold S, Yap A, Hamilton N. Multicomponent analysis
    of junctional movements regulated by Myosin II isoforms at the epithelial zonula
    adherens. <i>PLoS One</i>. 2011;6(7). doi:<a href="https://doi.org/10.1371/journal.pone.0022458">10.1371/journal.pone.0022458</a>
  apa: Smutny, M., Wu, S., Gomez, G., Mangold, S., Yap, A., &#38; Hamilton, N. (2011).
    Multicomponent analysis of junctional movements regulated by Myosin II isoforms
    at the epithelial zonula adherens. <i>PLoS One</i>. Public Library of Science.
    <a href="https://doi.org/10.1371/journal.pone.0022458">https://doi.org/10.1371/journal.pone.0022458</a>
  chicago: Smutny, Michael, Selwin Wu, Guillermo Gomez, Sabine Mangold, Alpha Yap,
    and Nicholas Hamilton. “Multicomponent Analysis of Junctional Movements Regulated
    by Myosin II Isoforms at the Epithelial Zonula Adherens.” <i>PLoS One</i>. Public
    Library of Science, 2011. <a href="https://doi.org/10.1371/journal.pone.0022458">https://doi.org/10.1371/journal.pone.0022458</a>.
  ieee: M. Smutny, S. Wu, G. Gomez, S. Mangold, A. Yap, and N. Hamilton, “Multicomponent
    analysis of junctional movements regulated by Myosin II isoforms at the epithelial
    zonula adherens,” <i>PLoS One</i>, vol. 6, no. 7. Public Library of Science, 2011.
  ista: Smutny M, Wu S, Gomez G, Mangold S, Yap A, Hamilton N. 2011. Multicomponent
    analysis of junctional movements regulated by Myosin II isoforms at the epithelial
    zonula adherens. PLoS One. 6(7).
  mla: Smutny, Michael, et al. “Multicomponent Analysis of Junctional Movements Regulated
    by Myosin II Isoforms at the Epithelial Zonula Adherens.” <i>PLoS One</i>, vol.
    6, no. 7, Public Library of Science, 2011, doi:<a href="https://doi.org/10.1371/journal.pone.0022458">10.1371/journal.pone.0022458</a>.
  short: M. Smutny, S. Wu, G. Gomez, S. Mangold, A. Yap, N. Hamilton, PLoS One 6 (2011).
date_created: 2018-12-11T12:02:28Z
date_published: 2011-07-22T00:00:00Z
date_updated: 2021-01-12T07:42:25Z
day: '22'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1371/journal.pone.0022458
file:
- access_level: open_access
  checksum: 57a5eb11dd05241c48c44f492b3ec3ac
  content_type: application/pdf
  creator: dernst
  date_created: 2019-05-10T10:51:43Z
  date_updated: 2020-07-14T12:46:06Z
  file_id: '6399'
  file_name: 2011_PLOS_Smutny.PDF
  file_size: 1984567
  relation: main_file
file_date_updated: 2020-07-14T12:46:06Z
has_accepted_license: '1'
intvolume: '         6'
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '3357'
quality_controlled: '1'
status: public
title: Multicomponent analysis of junctional movements regulated by Myosin II isoforms
  at the epithelial zonula adherens
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2011'
...
