---
_id: '538'
abstract:
- lang: ger
text: 'Optogenetik und Photopharmakologie ermöglichen präzise räumliche und zeitliche
Kontrolle von Proteinwechselwirkung und -funktion in Zellen und Tieren. Optogenetische
Methoden, die auf grünes Licht ansprechen und zum Trennen von Proteinkomplexen
geeignet sind, sind nichtweitläufig verfügbar, würden jedoch mehrfarbige Experimente
zur Beantwortung von biologischen Fragestellungen ermöglichen. Hier demonstrieren
wir die Verwendung von Cobalamin(Vitamin B12)-bindenden Domänen von bakteriellen
CarH-Transkriptionsfaktoren zur Grünlicht-induzierten Dissoziation von Rezeptoren.
Fusioniert mit dem Fibroblasten-W achstumsfaktor-Rezeptor 1 führten diese im Dunkeln
in kultivierten Zellen zu Signalaktivität durch Oligomerisierung, welche durch
Beleuchten umgehend aufgehoben wurde. In Zebrafischembryonen, die einen derartigen
Rezeptor exprimieren, ermöglichte grünes Licht die Kontrolle über abnormale Signalaktivität
während der Embryonalentwicklung. '
author:
- first_name: Stephanie
full_name: Kainrath, Stephanie
id: 32CFBA64-F248-11E8-B48F-1D18A9856A87
last_name: Kainrath
- first_name: Manuela
full_name: Stadler, Manuela
last_name: Stadler
- first_name: Eva
full_name: Gschaider-Reichhart, Eva
id: 3FEE232A-F248-11E8-B48F-1D18A9856A87
last_name: Gschaider-Reichhart
orcid: 0000-0002-7218-7738
- first_name: Martin
full_name: Distel, Martin
last_name: Distel
- first_name: Harald L
full_name: Janovjak, Harald L
id: 33BA6C30-F248-11E8-B48F-1D18A9856A87
last_name: Janovjak
orcid: 0000-0002-8023-9315
citation:
ama: Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Grünlicht-induzierte
Rezeptorinaktivierung durch Cobalamin-bindende Domänen. Angewandte Chemie.
2017;129(16):4679-4682. doi:10.1002/ange.201611998
apa: Kainrath, S., Stadler, M., Gschaider-Reichhart, E., Distel, M., & Janovjak,
H. L. (2017). Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende
Domänen. Angewandte Chemie. Wiley. https://doi.org/10.1002/ange.201611998
chicago: Kainrath, Stephanie, Manuela Stadler, Eva Gschaider-Reichhart, Martin Distel,
and Harald L Janovjak. “Grünlicht-Induzierte Rezeptorinaktivierung Durch Cobalamin-Bindende
Domänen.” Angewandte Chemie. Wiley, 2017. https://doi.org/10.1002/ange.201611998.
ieee: S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, and H. L. Janovjak,
“Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen,”
Angewandte Chemie, vol. 129, no. 16. Wiley, pp. 4679–4682, 2017.
ista: Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. 2017.
Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. Angewandte
Chemie. 129(16), 4679–4682.
mla: Kainrath, Stephanie, et al. “Grünlicht-Induzierte Rezeptorinaktivierung Durch
Cobalamin-Bindende Domänen.” Angewandte Chemie, vol. 129, no. 16, Wiley,
2017, pp. 4679–82, doi:10.1002/ange.201611998.
short: S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak,
Angewandte Chemie 129 (2017) 4679–4682.
date_created: 2018-12-11T11:47:02Z
date_published: 2017-05-20T00:00:00Z
date_updated: 2021-01-12T08:01:33Z
day: '20'
ddc:
- '571'
department:
- _id: CaGu
- _id: HaJa
doi: 10.1002/ange.201611998
ec_funded: 1
file:
- access_level: open_access
checksum: d66fee867e7cdbfa3fe276c2fb0778bb
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creator: system
date_created: 2018-12-12T10:13:24Z
date_updated: 2020-07-14T12:46:39Z
file_id: '5007'
file_name: IST-2018-932-v1+1_Kainrath_et_al-2017-Angewandte_Chemie.pdf
file_size: 1668557
relation: main_file
file_date_updated: 2020-07-14T12:46:39Z
has_accepted_license: '1'
intvolume: ' 129'
issue: '16'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '05'
oa: 1
oa_version: Published Version
page: 4679 - 4682
project:
- _id: 25548C20-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '303564'
name: Microbial Ion Channels for Synthetic Neurobiology
- _id: 255A6082-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication: Angewandte Chemie
publication_status: published
publisher: Wiley
publist_id: '7279'
pubrep_id: '932'
quality_controlled: '1'
status: public
title: Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 129
year: '2017'
...
---
_id: '256'
abstract:
- lang: eng
text: We show that a non-singular integral form of degree d is soluble over the
integers if and only if it is soluble over ℝ and over ℚp for all primes p, provided
that the form has at least (d - 1/2 √d)2d variables. This improves on a longstanding
result of Birch.
acknowledgement: While working on this paper the authors were supported by the Leverhulme
Trust and ERC grant 306457.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Sean
full_name: Prendiville, Sean
last_name: Prendiville
citation:
ama: Browning TD, Prendiville S. Improvements in Birch’s theorem on forms in many
variables. Journal fur die Reine und Angewandte Mathematik. 2017;2017(731):122.
doi:10.1515/crelle-2014-0122
apa: Browning, T. D., & Prendiville, S. (2017). Improvements in Birch’s theorem
on forms in many variables. Journal Fur Die Reine Und Angewandte Mathematik.
Walter de Gruyter. https://doi.org/10.1515/crelle-2014-0122
chicago: Browning, Timothy D, and Sean Prendiville. “Improvements in Birch’s Theorem
on Forms in Many Variables.” Journal Fur Die Reine Und Angewandte Mathematik.
Walter de Gruyter, 2017. https://doi.org/10.1515/crelle-2014-0122.
ieee: T. D. Browning and S. Prendiville, “Improvements in Birch’s theorem on forms
in many variables,” Journal fur die Reine und Angewandte Mathematik, vol.
2017, no. 731. Walter de Gruyter, p. 122, 2017.
ista: Browning TD, Prendiville S. 2017. Improvements in Birch’s theorem on forms
in many variables. Journal fur die Reine und Angewandte Mathematik. 2017(731),
122.
mla: Browning, Timothy D., and Sean Prendiville. “Improvements in Birch’s Theorem
on Forms in Many Variables.” Journal Fur Die Reine Und Angewandte Mathematik,
vol. 2017, no. 731, Walter de Gruyter, 2017, p. 122, doi:10.1515/crelle-2014-0122.
short: T.D. Browning, S. Prendiville, Journal Fur Die Reine Und Angewandte Mathematik
2017 (2017) 122.
date_created: 2018-12-11T11:45:28Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2024-03-05T12:09:21Z
day: '01'
doi: 10.1515/crelle-2014-0122
extern: '1'
external_id:
arxiv:
- '1402.4489'
intvolume: ' 2017'
issue: '731'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1402.4489
month: '10'
oa: 1
oa_version: Preprint
page: '122'
publication: Journal fur die Reine und Angewandte Mathematik
publication_identifier:
issn:
- 0075-4102
publication_status: published
publisher: Walter de Gruyter
publist_id: '7646'
quality_controlled: '1'
related_material:
record:
- id: '271'
relation: earlier_version
status: public
status: public
title: Improvements in Birch's theorem on forms in many variables
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2017
year: '2017'
...
---
_id: '265'
abstract:
- lang: eng
text: We establish the dimension and irreducibility of the moduli space of rational
curves (of fixed degree) on arbitrary smooth hypersurfaces of sufficiently low
degree. A spreading out argument reduces the problem to hypersurfaces defined
over finite fields of large cardinality, which can then be tackled using a function
field version of the Hardy-Littlewood circle method, in which particular care
is taken to ensure uniformity in the size of the underlying finite field.
acknowledgement: While working on this paper the first author was supported by ERC
grant 306457.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Pankaj
full_name: Vishe, Pankaj
last_name: Vishe
citation:
ama: Browning TD, Vishe P. Rational curves on smooth hypersurfaces of low degree.
Geometric Methods in Algebra and Number Theory. 2017;11(7):1657-1675. doi:10.2140/ant.2017.11.1657
apa: Browning, T. D., & Vishe, P. (2017). Rational curves on smooth hypersurfaces
of low degree. Geometric Methods in Algebra and Number Theory. Mathematical
Sciences Publishers. https://doi.org/10.2140/ant.2017.11.1657
chicago: Browning, Timothy D, and Pankaj Vishe. “Rational Curves on Smooth Hypersurfaces
of Low Degree.” Geometric Methods in Algebra and Number Theory. Mathematical
Sciences Publishers, 2017. https://doi.org/10.2140/ant.2017.11.1657.
ieee: T. D. Browning and P. Vishe, “Rational curves on smooth hypersurfaces of low
degree,” Geometric Methods in Algebra and Number Theory, vol. 11, no. 7. Mathematical
Sciences Publishers, pp. 1657–1675, 2017.
ista: Browning TD, Vishe P. 2017. Rational curves on smooth hypersurfaces of low
degree. Geometric Methods in Algebra and Number Theory. 11(7), 1657–1675.
mla: Browning, Timothy D., and Pankaj Vishe. “Rational Curves on Smooth Hypersurfaces
of Low Degree.” Geometric Methods in Algebra and Number Theory, vol. 11,
no. 7, Mathematical Sciences Publishers, 2017, pp. 1657–75, doi:10.2140/ant.2017.11.1657.
short: T.D. Browning, P. Vishe, Geometric Methods in Algebra and Number Theory 11
(2017) 1657–1675.
date_created: 2018-12-11T11:45:30Z
date_published: 2017-09-07T00:00:00Z
date_updated: 2024-03-05T11:43:38Z
day: '07'
doi: 10.2140/ant.2017.11.1657
extern: '1'
external_id:
arxiv:
- '1611.00553'
intvolume: ' 11'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1611.00553
month: '09'
oa: 1
oa_version: Preprint
page: 1657 - 1675
publication: Geometric Methods in Algebra and Number Theory
publication_identifier:
eissn:
- 1944-7833
publication_status: published
publisher: ' Mathematical Sciences Publishers'
publist_id: '7637'
quality_controlled: '1'
status: public
title: Rational curves on smooth hypersurfaces of low degree
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2017'
...
---
_id: '266'
abstract:
- lang: eng
text: We generalise Birch's seminal work on forms in many variables to handle a
system of forms in which the degrees need not all be the same. This allows us
to prove the Hasse principle, weak approximation, and the Manin-Peyre conjecture
for a smooth and geometrically integral variety X Pm, provided only that its dimension
is large enough in terms of its degree.
acknowledgement: While working on this paper the first author was supported by ERC
grant 306457.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Roger
full_name: Heath Brown, Roger
last_name: Heath Brown
citation:
ama: Browning TD, Heath Brown R. Forms in many variables and differing degrees.
Journal of the European Mathematical Society. 2017;19(2):357-394. doi:10.4171/JEMS/668
apa: Browning, T. D., & Heath Brown, R. (2017). Forms in many variables and
differing degrees. Journal of the European Mathematical Society. European
Mathematical Society Publishing House. https://doi.org/10.4171/JEMS/668
chicago: Browning, Timothy D, and Roger Heath Brown. “Forms in Many Variables and
Differing Degrees.” Journal of the European Mathematical Society. European
Mathematical Society Publishing House, 2017. https://doi.org/10.4171/JEMS/668.
ieee: T. D. Browning and R. Heath Brown, “Forms in many variables and differing
degrees,” Journal of the European Mathematical Society, vol. 19, no. 2.
European Mathematical Society Publishing House, pp. 357–394, 2017.
ista: Browning TD, Heath Brown R. 2017. Forms in many variables and differing degrees.
Journal of the European Mathematical Society. 19(2), 357–394.
mla: Browning, Timothy D., and Roger Heath Brown. “Forms in Many Variables and Differing
Degrees.” Journal of the European Mathematical Society, vol. 19, no. 2,
European Mathematical Society Publishing House, 2017, pp. 357–94, doi:10.4171/JEMS/668.
short: T.D. Browning, R. Heath Brown, Journal of the European Mathematical Society
19 (2017) 357–394.
date_created: 2018-12-11T11:45:31Z
date_published: 2017-01-26T00:00:00Z
date_updated: 2024-03-05T11:47:15Z
day: '26'
doi: 10.4171/JEMS/668
extern: '1'
external_id:
arxiv:
- '1403.5937'
intvolume: ' 19'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1403.5937
month: '01'
oa: 1
oa_version: Preprint
page: 357 - 394
publication: Journal of the European Mathematical Society
publication_status: published
publisher: European Mathematical Society Publishing House
publist_id: '7636'
quality_controlled: '1'
status: public
title: Forms in many variables and differing degrees
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2017'
...
---
_id: '267'
abstract:
- lang: eng
text: Building on recent work of Bhargava, Elkies and Schnidman and of Kriz and
Li, we produce infinitely many smooth cubic surfaces defined over the field of
rational numbers that contain rational points.
acknowledgement: While working on this paper the author was supported by ERC grant
306457.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
citation:
ama: Browning TD. Many cubic surfaces contain rational points. Mathematika.
2017;63(3):818-839. doi:10.1112/S0025579317000195
apa: Browning, T. D. (2017). Many cubic surfaces contain rational points. Mathematika.
Cambridge University Press. https://doi.org/10.1112/S0025579317000195
chicago: Browning, Timothy D. “Many Cubic Surfaces Contain Rational Points.” Mathematika.
Cambridge University Press, 2017. https://doi.org/10.1112/S0025579317000195.
ieee: T. D. Browning, “Many cubic surfaces contain rational points,” Mathematika,
vol. 63, no. 3. Cambridge University Press, pp. 818–839, 2017.
ista: Browning TD. 2017. Many cubic surfaces contain rational points. Mathematika.
63(3), 818–839.
mla: Browning, Timothy D. “Many Cubic Surfaces Contain Rational Points.” Mathematika,
vol. 63, no. 3, Cambridge University Press, 2017, pp. 818–39, doi:10.1112/S0025579317000195.
short: T.D. Browning, Mathematika 63 (2017) 818–839.
date_created: 2018-12-11T11:45:31Z
date_published: 2017-11-29T00:00:00Z
date_updated: 2024-03-05T11:49:27Z
day: '29'
doi: 10.1112/S0025579317000195
extern: '1'
external_id:
arxiv:
- '1701.00525'
intvolume: ' 63'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1701.00525
month: '11'
oa: 1
oa_version: Preprint
page: 818 - 839
publication: Mathematika
publication_identifier:
issn:
- 0025-5793
publication_status: published
publisher: Cambridge University Press
publist_id: '7635'
quality_controlled: '1'
status: public
title: Many cubic surfaces contain rational points
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 63
year: '2017'
...
---
_id: '268'
abstract:
- lang: eng
text: We show that any subset of the squares of positive relative upper density
contains nontrivial solutions to a translation-invariant linear equation in five
or more variables, with explicit quantitative bounds. As a consequence, we establish
the partition regularity of any diagonal quadric in five or more variables whose
coefficients sum to zero. Unlike previous approaches, which are limited to equations
in seven or more variables, we employ transference technology of Green to import
bounds from the linear setting.
acknowledgement: Whilst working on this paper the authors were supported by ERC grant
306457.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Sean
full_name: Prendiville, Sean
last_name: Prendiville
citation:
ama: Browning TD, Prendiville S. A transference approach to a Roth-type theorem
in the squares. International Mathematics Research Notices. 2017;2017(7):2219-2248.
doi:10.1093/imrn/rnw096
apa: Browning, T. D., & Prendiville, S. (2017). A transference approach to a
Roth-type theorem in the squares. International Mathematics Research Notices.
Oxford University Press. https://doi.org/10.1093/imrn/rnw096
chicago: Browning, Timothy D, and Sean Prendiville. “A Transference Approach to
a Roth-Type Theorem in the Squares.” International Mathematics Research Notices.
Oxford University Press, 2017. https://doi.org/10.1093/imrn/rnw096.
ieee: T. D. Browning and S. Prendiville, “A transference approach to a Roth-type
theorem in the squares,” International Mathematics Research Notices, vol.
2017, no. 7. Oxford University Press, pp. 2219–2248, 2017.
ista: Browning TD, Prendiville S. 2017. A transference approach to a Roth-type theorem
in the squares. International Mathematics Research Notices. 2017(7), 2219–2248.
mla: Browning, Timothy D., and Sean Prendiville. “A Transference Approach to a Roth-Type
Theorem in the Squares.” International Mathematics Research Notices, vol.
2017, no. 7, Oxford University Press, 2017, pp. 2219–48, doi:10.1093/imrn/rnw096.
short: T.D. Browning, S. Prendiville, International Mathematics Research Notices
2017 (2017) 2219–2248.
date_created: 2018-12-11T11:45:31Z
date_published: 2017-04-01T00:00:00Z
date_updated: 2024-03-05T11:52:36Z
day: '01'
doi: 10.1093/imrn/rnw096
extern: '1'
external_id:
arxiv:
- '1510.00136'
intvolume: ' 2017'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1510.00136
month: '04'
oa: 1
oa_version: Preprint
page: 2219 - 2248
publication: International Mathematics Research Notices
publication_identifier:
issn:
- 1073-7928
publication_status: published
publisher: Oxford University Press
publist_id: '7634'
quality_controlled: '1'
status: public
title: A transference approach to a Roth-type theorem in the squares
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2017
year: '2017'
...
---
_id: '269'
abstract:
- lang: eng
text: We investigate Fano varieties defined over a number field that contain subvarieties
whose number of rational points of bounded height is comparable to the total number
on the variety.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Daniel
full_name: Loughran, Daniel
last_name: Loughran
citation:
ama: Browning TD, Loughran D. Varieties with too many rational points. Mathematische
Zeitschrift. 2017;285(3-4):1249-1267. doi:10.1007/s00209-016-1746-2
apa: Browning, T. D., & Loughran, D. (2017). Varieties with too many rational
points. Mathematische Zeitschrift. Springer. https://doi.org/10.1007/s00209-016-1746-2
chicago: Browning, Timothy D, and Daniel Loughran. “Varieties with Too Many Rational
Points.” Mathematische Zeitschrift. Springer, 2017. https://doi.org/10.1007/s00209-016-1746-2.
ieee: T. D. Browning and D. Loughran, “Varieties with too many rational points,”
Mathematische Zeitschrift, vol. 285, no. 3–4. Springer, pp. 1249–1267,
2017.
ista: Browning TD, Loughran D. 2017. Varieties with too many rational points. Mathematische
Zeitschrift. 285(3–4), 1249–1267.
mla: Browning, Timothy D., and Daniel Loughran. “Varieties with Too Many Rational
Points.” Mathematische Zeitschrift, vol. 285, no. 3–4, Springer, 2017,
pp. 1249–67, doi:10.1007/s00209-016-1746-2.
short: T.D. Browning, D. Loughran, Mathematische Zeitschrift 285 (2017) 1249–1267.
date_created: 2018-12-11T11:45:32Z
date_published: 2017-04-01T00:00:00Z
date_updated: 2024-03-05T11:56:29Z
day: '01'
doi: 10.1007/s00209-016-1746-2
extern: '1'
external_id:
arxiv:
- '1311.5755'
intvolume: ' 285'
issue: 3-4
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1311.5755
month: '04'
oa: 1
oa_version: Preprint
page: 1249 - 1267
publication: Mathematische Zeitschrift
publication_status: published
publisher: Springer
publist_id: '7633'
quality_controlled: '1'
status: public
title: Varieties with too many rational points
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 285
year: '2017'
...
---
_id: '270'
abstract:
- lang: eng
text: Given a symmetric variety Y defined over Q and a non-zero polynomial with
integer coefficients, we use techniques from homogeneous dynamics to establish
conditions under which the polynomial can be made r-free for a Zariski dense set
of integral points on Y . We also establish an asymptotic counting formula for
this set. In the special case that Y is a quadric hypersurface, we give explicit
bounds on the size of r by combining the argument with a uniform upper bound for
the density of integral points on general affine quadrics defined over Q.
acknowledgement: While working on this paper the authors were supported by ERC grants
306457 and 239606, respectively.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Alexander
full_name: Gorodnik, Alexander
last_name: Gorodnik
citation:
ama: Browning TD, Gorodnik A. Power-free values of polynomials on symmetric varieties.
Proceedings of the London Mathematical Society. 2017;114(6):1044-1080.
doi:10.1112/plms.12030
apa: Browning, T. D., & Gorodnik, A. (2017). Power-free values of polynomials
on symmetric varieties. Proceedings of the London Mathematical Society.
Wiley. https://doi.org/10.1112/plms.12030
chicago: Browning, Timothy D, and Alexander Gorodnik. “Power-Free Values of Polynomials
on Symmetric Varieties.” Proceedings of the London Mathematical Society.
Wiley, 2017. https://doi.org/10.1112/plms.12030.
ieee: T. D. Browning and A. Gorodnik, “Power-free values of polynomials on symmetric
varieties,” Proceedings of the London Mathematical Society, vol. 114, no.
6. Wiley, pp. 1044–1080, 2017.
ista: Browning TD, Gorodnik A. 2017. Power-free values of polynomials on symmetric
varieties. Proceedings of the London Mathematical Society. 114(6), 1044–1080.
mla: Browning, Timothy D., and Alexander Gorodnik. “Power-Free Values of Polynomials
on Symmetric Varieties.” Proceedings of the London Mathematical Society,
vol. 114, no. 6, Wiley, 2017, pp. 1044–80, doi:10.1112/plms.12030.
short: T.D. Browning, A. Gorodnik, Proceedings of the London Mathematical Society
114 (2017) 1044–1080.
date_created: 2018-12-11T11:45:32Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2024-03-05T11:58:25Z
day: '01'
doi: 10.1112/plms.12030
extern: '1'
external_id:
arxiv:
- '1606.06342'
intvolume: ' 114'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1606.06342
month: '06'
oa: 1
oa_version: Preprint
page: 1044 - 1080
publication: Proceedings of the London Mathematical Society
publication_identifier:
issn:
- 0024-6115
publication_status: published
publisher: Wiley
publist_id: '7632'
quality_controlled: '1'
status: public
title: Power-free values of polynomials on symmetric varieties
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...
---
_id: '272'
abstract:
- lang: eng
text: Given a number field K/Q and a polynomial P ε Q [t], all of whose roots are
Q, let X be the variety defined by the equation NK (x) = P (t). Combining additive
combinatiorics with descent we show that the Brauer-Manin obstruction is the only
obstruction to the Hesse principle and weak approximation on any smooth and projective
model of X.
acknowledgement: While working on this paper the first author was supported by ERC
grant 306457 and the second author was supported by EPSRC grant EP/E053262/1 and
by ERC grant 208091. Some of this work was carried out during the programme “Arithmetic
and geometry” in 2013 at the Hausdorff Institute in Bonn.
article_processing_charge: No
article_type: original
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Lilian
full_name: Matthiesen, Lilian
last_name: Matthiesen
citation:
ama: Browning TD, Matthiesen L. Norm forms for arbitrary number fields as products
of linear polynomials. Annales Scientifiques de l’Ecole Normale Superieure.
2017;50(6):1383-1446. doi:10.24033/asens.2348
apa: Browning, T. D., & Matthiesen, L. (2017). Norm forms for arbitrary number
fields as products of linear polynomials. Annales Scientifiques de l’Ecole
Normale Superieure. Societe Mathematique de France. https://doi.org/10.24033/asens.2348
chicago: Browning, Timothy D, and Lilian Matthiesen. “Norm Forms for Arbitrary Number
Fields as Products of Linear Polynomials.” Annales Scientifiques de l’Ecole
Normale Superieure. Societe Mathematique de France, 2017. https://doi.org/10.24033/asens.2348.
ieee: T. D. Browning and L. Matthiesen, “Norm forms for arbitrary number fields
as products of linear polynomials,” Annales Scientifiques de l’Ecole Normale
Superieure, vol. 50, no. 6. Societe Mathematique de France, pp. 1383–1446,
2017.
ista: Browning TD, Matthiesen L. 2017. Norm forms for arbitrary number fields as
products of linear polynomials. Annales Scientifiques de l’Ecole Normale Superieure.
50(6), 1383–1446.
mla: Browning, Timothy D., and Lilian Matthiesen. “Norm Forms for Arbitrary Number
Fields as Products of Linear Polynomials.” Annales Scientifiques de l’Ecole
Normale Superieure, vol. 50, no. 6, Societe Mathematique de France, 2017,
pp. 1383–446, doi:10.24033/asens.2348.
short: T.D. Browning, L. Matthiesen, Annales Scientifiques de l’Ecole Normale Superieure
50 (2017) 1383–1446.
date_created: 2018-12-11T11:45:32Z
date_published: 2017-12-01T00:00:00Z
date_updated: 2024-03-05T12:13:35Z
day: '01'
doi: 10.24033/asens.2348
extern: '1'
intvolume: ' 50'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://research-information.bristol.ac.uk/en/publications/norm-forms-for-arbitrary-number-fields-as-products-of-linear-polynomials(f79a584b-ec58-47c8-aa97-8c5505e3f751).html
month: '12'
oa: 1
oa_version: Submitted Version
page: 1383 - 1446
publication: Annales Scientifiques de l'Ecole Normale Superieure
publication_status: published
publisher: Societe Mathematique de France
publist_id: '7630'
quality_controlled: '1'
status: public
title: Norm forms for arbitrary number fields as products of linear polynomials
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 50
year: '2017'
...
---
_id: '274'
abstract:
- lang: eng
text: We consider the problem of estimating the partition function Z(β)=∑xexp(−β(H(x))
of a Gibbs distribution with a Hamilton H(⋅), or more precisely the logarithm
of the ratio q=lnZ(0)/Z(β). It has been recently shown how to approximate q with
high probability assuming the existence of an oracle that produces samples from
the Gibbs distribution for a given parameter value in [0,β]. The current best
known approach due to Huber [9] uses O(qlnn⋅[lnq+lnlnn+ε−2]) oracle calls on average
where ε is the desired accuracy of approximation and H(⋅) is assumed to lie in
{0}∪[1,n]. We improve the complexity to O(qlnn⋅ε−2) oracle calls. We also show
that the same complexity can be achieved if exact oracles are replaced with approximate
sampling oracles that are within O(ε2qlnn) variation distance from exact oracles.
Finally, we prove a lower bound of Ω(q⋅ε−2) oracle calls under a natural model
of computation.
article_processing_charge: No
arxiv: 1
author:
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
citation:
ama: 'Kolmogorov V. A faster approximation algorithm for the Gibbs partition function.
In: Proceedings of the 31st Conference On Learning Theory. Vol 75. ML Research
Press; 2017:228-249.'
apa: Kolmogorov, V. (2017). A faster approximation algorithm for the Gibbs partition
function. In Proceedings of the 31st Conference On Learning Theory (Vol.
75, pp. 228–249). ML Research Press.
chicago: Kolmogorov, Vladimir. “A Faster Approximation Algorithm for the Gibbs Partition
Function.” In Proceedings of the 31st Conference On Learning Theory, 75:228–49.
ML Research Press, 2017.
ieee: V. Kolmogorov, “A faster approximation algorithm for the Gibbs partition function,”
in Proceedings of the 31st Conference On Learning Theory, 2017, vol. 75,
pp. 228–249.
ista: 'Kolmogorov V. 2017. A faster approximation algorithm for the Gibbs partition
function. Proceedings of the 31st Conference On Learning Theory. COLT: Annual
Conference on Learning Theory vol. 75, 228–249.'
mla: Kolmogorov, Vladimir. “A Faster Approximation Algorithm for the Gibbs Partition
Function.” Proceedings of the 31st Conference On Learning Theory, vol.
75, ML Research Press, 2017, pp. 228–49.
short: V. Kolmogorov, in:, Proceedings of the 31st Conference On Learning Theory,
ML Research Press, 2017, pp. 228–249.
conference:
end_date: 2018-07-09
name: 'COLT: Annual Conference on Learning Theory '
start_date: 2018-07-06
date_created: 2018-12-11T11:45:33Z
date_published: 2017-12-27T00:00:00Z
date_updated: 2023-10-17T12:32:13Z
day: '27'
ddc:
- '510'
department:
- _id: VlKo
ec_funded: 1
external_id:
arxiv:
- '1608.04223'
file:
- access_level: open_access
checksum: 89db06a0e8083524449cb59b56bf4e5b
content_type: application/pdf
creator: dernst
date_created: 2020-05-12T09:23:27Z
date_updated: 2020-07-14T12:45:45Z
file_id: '7820'
file_name: 2018_PMLR_Kolmogorov.pdf
file_size: 408974
relation: main_file
file_date_updated: 2020-07-14T12:45:45Z
has_accepted_license: '1'
intvolume: ' 75'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 228-249
project:
- _id: 25FBA906-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '616160'
name: 'Discrete Optimization in Computer Vision: Theory and Practice'
publication: Proceedings of the 31st Conference On Learning Theory
publication_status: published
publisher: ML Research Press
publist_id: '7628'
quality_controlled: '1'
status: public
title: A faster approximation algorithm for the Gibbs partition function
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 75
year: '2017'
...
---
_id: '313'
abstract:
- lang: eng
text: 'Tunneling of a particle through a potential barrier remains one of the most
remarkable quantum phenomena. Owing to advances in laser technology, electric
fields comparable to those electrons experience in atoms are readily generated
and open opportunities to dynamically investigate the process of electron tunneling
through the potential barrier formed by the superposition of both laser and atomic
fields. Attosecond-time and angstrom-space resolution of the strong laser-field
technique allow to address fundamental questions related to tunneling, which are
still open and debated: Which time is spent under the barrier and what momentum
is picked up by the particle in the meantime? In this combined experimental and
theoretical study we demonstrate that for strong-field ionization the leading
quantum mechanical Wigner treatment for the time resolved description of tunneling
is valid. We achieve a high sensitivity on the tunneling barrier and unambiguously
isolate its effects by performing a differential study of two systems with almost
identical tunneling geometry. Moreover, working with a low frequency laser, we
essentially limit the non-adiabaticity of the process as a major source of uncertainty.
The agreement between experiment and theory implies two substantial corrections
with respect to the widely employed quasiclassical treatment: In addition to a
non-vanishing longitudinal momentum along the laser field-direction we provide
clear evidence for a non-zero tunneling time delay. This addresses also the fundamental
question how the transition occurs from the tunnel barrier to free space classical
evolution of the ejected electron.'
alternative_title:
- 'Journal of Physics: Conference Series'
article_number: '012004'
arxiv: 1
author:
- first_name: Nicolas
full_name: Camus, Nicolas
last_name: Camus
- first_name: Enderalp
full_name: Yakaboylu, Enderalp
id: 38CB71F6-F248-11E8-B48F-1D18A9856A87
last_name: Yakaboylu
orcid: 0000-0001-5973-0874
- first_name: Lutz
full_name: Fechner, Lutz
last_name: Fechner
- first_name: Michael
full_name: Klaiber, Michael
last_name: Klaiber
- first_name: Martin
full_name: Laux, Martin
last_name: Laux
- first_name: Yonghao
full_name: Mi, Yonghao
last_name: Mi
- first_name: Karen
full_name: Hatsagortsyan, Karen
last_name: Hatsagortsyan
- first_name: Thomas
full_name: Pfeifer, Thomas
last_name: Pfeifer
- first_name: Cristoph
full_name: Keitel, Cristoph
last_name: Keitel
- first_name: Robert
full_name: Moshammer, Robert
last_name: Moshammer
citation:
ama: 'Camus N, Yakaboylu E, Fechner L, et al. Experimental evidence for Wigner’s
tunneling time. In: Vol 999. American Physical Society; 2017. doi:10.1088/1742-6596/999/1/012004'
apa: 'Camus, N., Yakaboylu, E., Fechner, L., Klaiber, M., Laux, M., Mi, Y., … Moshammer,
R. (2017). Experimental evidence for Wigner’s tunneling time (Vol. 999). Presented
at the Annual International Laser Physics Workshop LPHYS, Kazan, Russian Federation:
American Physical Society. https://doi.org/10.1088/1742-6596/999/1/012004'
chicago: Camus, Nicolas, Enderalp Yakaboylu, Lutz Fechner, Michael Klaiber, Martin
Laux, Yonghao Mi, Karen Hatsagortsyan, Thomas Pfeifer, Cristoph Keitel, and Robert
Moshammer. “Experimental Evidence for Wigner’s Tunneling Time,” Vol. 999. American
Physical Society, 2017. https://doi.org/10.1088/1742-6596/999/1/012004.
ieee: N. Camus et al., “Experimental evidence for Wigner’s tunneling time,”
presented at the Annual International Laser Physics Workshop LPHYS, Kazan, Russian
Federation, 2017, vol. 999, no. 1.
ista: 'Camus N, Yakaboylu E, Fechner L, Klaiber M, Laux M, Mi Y, Hatsagortsyan K,
Pfeifer T, Keitel C, Moshammer R. 2017. Experimental evidence for Wigner’s tunneling
time. Annual International Laser Physics Workshop LPHYS, Journal of Physics: Conference
Series, vol. 999, 012004.'
mla: Camus, Nicolas, et al. Experimental Evidence for Wigner’s Tunneling Time.
Vol. 999, no. 1, 012004, American Physical Society, 2017, doi:10.1088/1742-6596/999/1/012004.
short: N. Camus, E. Yakaboylu, L. Fechner, M. Klaiber, M. Laux, Y. Mi, K. Hatsagortsyan,
T. Pfeifer, C. Keitel, R. Moshammer, in:, American Physical Society, 2017.
conference:
end_date: 2017-08-21
location: Kazan, Russian Federation
name: Annual International Laser Physics Workshop LPHYS
start_date: 2017-08-17
date_created: 2018-12-11T11:45:46Z
date_published: 2017-07-14T00:00:00Z
date_updated: 2023-02-23T12:36:07Z
day: '14'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1088/1742-6596/999/1/012004
external_id:
arxiv:
- '1611.03701'
file:
- access_level: open_access
checksum: 6e70b525a84f6d5fb175c48e9f5cb59a
content_type: application/pdf
creator: dernst
date_created: 2019-01-22T08:34:10Z
date_updated: 2020-07-14T12:46:00Z
file_id: '5871'
file_name: 2017_Physics_Camus.pdf
file_size: 949321
relation: main_file
file_date_updated: 2020-07-14T12:46:00Z
has_accepted_license: '1'
intvolume: ' 999'
issue: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication_identifier:
issn:
- '17426588'
publication_status: published
publisher: American Physical Society
publist_id: '7552'
quality_controlled: '1'
related_material:
record:
- id: '6013'
relation: later_version
status: public
scopus_import: 1
status: public
title: Experimental evidence for Wigner's tunneling time
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 999
year: '2017'
...
---
_id: '1085'
abstract:
- lang: eng
text: Sex chromosomes evolve once recombination is halted between a homologous pair
of chromosomes. The dominant model of sex chromosome evolution posits that recombination
is suppressed between emerging X and Y chromosomes in order to resolve sexual
conflict. Here we test this model using whole genome and transcriptome resequencing
data in the guppy, a model for sexual selection with many Y-linked colour traits.
We show that although the nascent Y chromosome encompasses nearly half of the
linkage group, there has been no perceptible degradation of Y chromosome gene
content or activity. Using replicate wild populations with differing levels of
sexually antagonistic selection for colour, we also show that sexual selection
leads to greater expansion of the non-recombining region and increased Y chromosome
divergence. These results provide empirical support for longstanding models of
sex chromosome catalysis, and suggest an important role for sexual selection and
sexual conflict in genome evolution.
article_number: '14251'
article_processing_charge: No
author:
- first_name: Alison
full_name: Wright, Alison
last_name: Wright
- first_name: Iulia
full_name: Darolti, Iulia
last_name: Darolti
- first_name: Natasha
full_name: Bloch, Natasha
last_name: Bloch
- first_name: Vicencio
full_name: Oostra, Vicencio
last_name: Oostra
- first_name: Benjamin
full_name: Sandkam, Benjamin
last_name: Sandkam
- first_name: Séverine
full_name: Buechel, Séverine
last_name: Buechel
- first_name: Niclas
full_name: Kolm, Niclas
last_name: Kolm
- first_name: Felix
full_name: Breden, Felix
last_name: Breden
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Judith
full_name: Mank, Judith
last_name: Mank
citation:
ama: Wright A, Darolti I, Bloch N, et al. Convergent recombination suppression suggests
role of sexual selection in guppy sex chromosome formation. Nature Communications.
2017;8. doi:10.1038/ncomms14251
apa: Wright, A., Darolti, I., Bloch, N., Oostra, V., Sandkam, B., Buechel, S., …
Mank, J. (2017). Convergent recombination suppression suggests role of sexual
selection in guppy sex chromosome formation. Nature Communications. Nature
Publishing Group. https://doi.org/10.1038/ncomms14251
chicago: Wright, Alison, Iulia Darolti, Natasha Bloch, Vicencio Oostra, Benjamin
Sandkam, Séverine Buechel, Niclas Kolm, Felix Breden, Beatriz Vicoso, and Judith
Mank. “Convergent Recombination Suppression Suggests Role of Sexual Selection
in Guppy Sex Chromosome Formation.” Nature Communications. Nature Publishing
Group, 2017. https://doi.org/10.1038/ncomms14251.
ieee: A. Wright et al., “Convergent recombination suppression suggests role
of sexual selection in guppy sex chromosome formation,” Nature Communications,
vol. 8. Nature Publishing Group, 2017.
ista: Wright A, Darolti I, Bloch N, Oostra V, Sandkam B, Buechel S, Kolm N, Breden
F, Vicoso B, Mank J. 2017. Convergent recombination suppression suggests role
of sexual selection in guppy sex chromosome formation. Nature Communications.
8, 14251.
mla: Wright, Alison, et al. “Convergent Recombination Suppression Suggests Role
of Sexual Selection in Guppy Sex Chromosome Formation.” Nature Communications,
vol. 8, 14251, Nature Publishing Group, 2017, doi:10.1038/ncomms14251.
short: A. Wright, I. Darolti, N. Bloch, V. Oostra, B. Sandkam, S. Buechel, N. Kolm,
F. Breden, B. Vicoso, J. Mank, Nature Communications 8 (2017).
date_created: 2018-12-11T11:50:04Z
date_published: 2017-01-31T00:00:00Z
date_updated: 2023-09-20T11:48:16Z
day: '31'
ddc:
- '570'
- '576'
department:
- _id: BeVi
doi: 10.1038/ncomms14251
external_id:
isi:
- '000392953700001'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:22Z
date_updated: 2018-12-12T10:15:22Z
file_id: '5141'
file_name: IST-2017-791-v1+1_ncomms14251.pdf
file_size: 955256
relation: main_file
file_date_updated: 2018-12-12T10:15:22Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- '20411723'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6292'
pubrep_id: '791'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Convergent recombination suppression suggests role of sexual selection in guppy
sex chromosome formation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2017'
...
---
_id: '1086'
abstract:
- lang: eng
text: 'Characterisation of G protein-coupled receptors (GPCR) relies on the availability
of a toolbox of ligands that selectively modulate different functional states
of the receptors. To uncover such molecules, we explored a unique strategy for
ligand discovery that takes advantage of the evolutionary conservation of the
600-million-year-old oxytocin/vasopressin signalling system. We isolated the insect
oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius niger),
identified and cloned its cognate receptor and determined its pharmacological
properties on the insect and human oxytocin/vasopressin receptors. Subsequently,
we identified a functional dichotomy: inotocin activated the insect inotocin and
the human vasopressin V1b receptors, but inhibited the human V1aR. Replacement
of Arg8 of inotocin by D-Arg8 led to a potent, stable and competitive V1aR-antagonist
([D-Arg8]-inotocin) with a 3,000-fold binding selectivity for the human V1aR over
the other three subtypes, OTR, V1bR and V2R. The Arg8/D-Arg8 ligand-pair was further
investigated to gain novel insights into the oxytocin/vasopressin peptide-receptor
interaction, which led to the identification of key residues of the receptors
that are important for ligand functionality and selectivity. These observations
could play an important role for development of oxytocin/vasopressin receptor
modulators that would enable clear distinction of the physiological and pathological
responses of the individual receptor subtypes.'
article_processing_charge: No
author:
- first_name: Maria
full_name: Di Giglio, Maria
last_name: Di Giglio
- first_name: Markus
full_name: Muttenthaler, Markus
last_name: Muttenthaler
- first_name: Kasper
full_name: Harpsøe, Kasper
last_name: Harpsøe
- first_name: Zita
full_name: Liutkeviciute, Zita
last_name: Liutkeviciute
- first_name: Peter
full_name: Keov, Peter
last_name: Keov
- first_name: Thomas
full_name: Eder, Thomas
last_name: Eder
- first_name: Thomas
full_name: Rattei, Thomas
last_name: Rattei
- first_name: Sarah
full_name: Arrowsmith, Sarah
last_name: Arrowsmith
- first_name: Susan
full_name: Wray, Susan
last_name: Wray
- first_name: Ales
full_name: Marek, Ales
last_name: Marek
- first_name: Tomas
full_name: Elbert, Tomas
last_name: Elbert
- first_name: Paul
full_name: Alewood, Paul
last_name: Alewood
- first_name: David
full_name: Gloriam, David
last_name: Gloriam
- first_name: Christian
full_name: Gruber, Christian
last_name: Gruber
citation:
ama: Di Giglio M, Muttenthaler M, Harpsøe K, et al. Development of a human vasopressin
V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Scientific
Reports. 2017;7:41002. doi:10.1038/srep41002
apa: Di Giglio, M., Muttenthaler, M., Harpsøe, K., Liutkeviciute, Z., Keov, P.,
Eder, T., … Gruber, C. (2017). Development of a human vasopressin V1a-receptor
antagonist from an evolutionary-related insect neuropeptide. Scientific Reports.
Nature Publishing Group. https://doi.org/10.1038/srep41002
chicago: Di Giglio, Maria, Markus Muttenthaler, Kasper Harpsøe, Zita Liutkeviciute,
Peter Keov, Thomas Eder, Thomas Rattei, et al. “Development of a Human Vasopressin
V1a-Receptor Antagonist from an Evolutionary-Related Insect Neuropeptide.” Scientific
Reports. Nature Publishing Group, 2017. https://doi.org/10.1038/srep41002.
ieee: M. Di Giglio et al., “Development of a human vasopressin V1a-receptor
antagonist from an evolutionary-related insect neuropeptide,” Scientific Reports,
vol. 7. Nature Publishing Group, p. 41002, 2017.
ista: Di Giglio M, Muttenthaler M, Harpsøe K, Liutkeviciute Z, Keov P, Eder T, Rattei
T, Arrowsmith S, Wray S, Marek A, Elbert T, Alewood P, Gloriam D, Gruber C. 2017.
Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related
insect neuropeptide. Scientific Reports. 7, 41002.
mla: Di Giglio, Maria, et al. “Development of a Human Vasopressin V1a-Receptor Antagonist
from an Evolutionary-Related Insect Neuropeptide.” Scientific Reports,
vol. 7, Nature Publishing Group, 2017, p. 41002, doi:10.1038/srep41002.
short: M. Di Giglio, M. Muttenthaler, K. Harpsøe, Z. Liutkeviciute, P. Keov, T.
Eder, T. Rattei, S. Arrowsmith, S. Wray, A. Marek, T. Elbert, P. Alewood, D. Gloriam,
C. Gruber, Scientific Reports 7 (2017) 41002.
date_created: 2018-12-11T11:50:04Z
date_published: 2017-02-01T00:00:00Z
date_updated: 2023-09-20T11:47:47Z
day: '01'
ddc:
- '570'
- '590'
doi: 10.1038/srep41002
external_id:
isi:
- '000393163800001'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:59Z
date_updated: 2018-12-12T10:14:59Z
file_id: '5115'
file_name: IST-2017-790-v1+1_srep41002_1_.pdf
file_size: 1994139
relation: main_file
file_date_updated: 2018-12-12T10:14:59Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '41002'
publication: Scientific Reports
publication_status: published
publisher: Nature Publishing Group
publist_id: '6291'
pubrep_id: '790'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related
insect neuropeptide
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7
year: '2017'
...
---
_id: '1087'
abstract:
- lang: eng
text: Using extensive direct numerical simulations, the dynamics of laminar-turbulent
fronts in pipe flow is investigated for Reynolds numbers between and 5500. We
here investigate the physical distinction between the fronts of weak and strong
slugs both by analysing the turbulent kinetic energy budget and by comparing the
downstream front motion to the advection speed of bulk turbulent structures. Our
study shows that weak downstream fronts travel slower than turbulent structures
in the bulk and correspond to decaying turbulence at the front. At the downstream
front speed becomes faster than the advection speed, marking the onset of strong
fronts. In contrast to weak fronts, turbulent eddies are generated at strong fronts
by feeding on the downstream laminar flow. Our study also suggests that temporal
fluctuations of production and dissipation at the downstream laminar-turbulent
front drive the dynamical switches between the two types of front observed up
to.
acknowledged_ssus:
- _id: ScienComp
article_processing_charge: No
author:
- first_name: Baofang
full_name: Song, Baofang
last_name: Song
- first_name: Dwight
full_name: Barkley, Dwight
last_name: Barkley
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Marc
full_name: Avila, Marc
last_name: Avila
citation:
ama: Song B, Barkley D, Hof B, Avila M. Speed and structure of turbulent fronts
in pipe flow. Journal of Fluid Mechanics. 2017;813:1045-1059. doi:10.1017/jfm.2017.14
apa: Song, B., Barkley, D., Hof, B., & Avila, M. (2017). Speed and structure
of turbulent fronts in pipe flow. Journal of Fluid Mechanics. Cambridge
University Press. https://doi.org/10.1017/jfm.2017.14
chicago: Song, Baofang, Dwight Barkley, Björn Hof, and Marc Avila. “Speed and Structure
of Turbulent Fronts in Pipe Flow.” Journal of Fluid Mechanics. Cambridge
University Press, 2017. https://doi.org/10.1017/jfm.2017.14.
ieee: B. Song, D. Barkley, B. Hof, and M. Avila, “Speed and structure of turbulent
fronts in pipe flow,” Journal of Fluid Mechanics, vol. 813. Cambridge University
Press, pp. 1045–1059, 2017.
ista: Song B, Barkley D, Hof B, Avila M. 2017. Speed and structure of turbulent
fronts in pipe flow. Journal of Fluid Mechanics. 813, 1045–1059.
mla: Song, Baofang, et al. “Speed and Structure of Turbulent Fronts in Pipe Flow.”
Journal of Fluid Mechanics, vol. 813, Cambridge University Press, 2017,
pp. 1045–59, doi:10.1017/jfm.2017.14.
short: B. Song, D. Barkley, B. Hof, M. Avila, Journal of Fluid Mechanics 813 (2017)
1045–1059.
date_created: 2018-12-11T11:50:04Z
date_published: 2017-02-25T00:00:00Z
date_updated: 2023-09-20T11:47:22Z
day: '25'
department:
- _id: BjHo
doi: 10.1017/jfm.2017.14
ec_funded: 1
external_id:
isi:
- '000394376400044'
intvolume: ' 813'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1603.04077
month: '02'
oa: 1
oa_version: Submitted Version
page: 1045 - 1059
project:
- _id: 25152F3A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '306589'
name: Decoding the complexity of turbulence at its origin
publication: Journal of Fluid Mechanics
publication_identifier:
issn:
- '00221120'
publication_status: published
publisher: Cambridge University Press
publist_id: '6290'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Speed and structure of turbulent fronts in pipe flow
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 813
year: '2017'
...
---
_id: '1089'
abstract:
- lang: eng
text: We discuss properties of distributions that are multivariate totally positive
of order two (MTP2) related to conditional independence. In particular, we show
that any independence model generated by an MTP2 distribution is a compositional
semigraphoid which is upward-stable and singleton-transitive. In addition, we
prove that any MTP2 distribution satisfying an appropriate support condition is
faithful to its concentration graph. Finally, we analyze factorization properties
of MTP2 distributions and discuss ways of constructing MTP2 distributions; in
particular we give conditions on the log-linear parameters of a discrete distribution
which ensure MTP2 and characterize conditional Gaussian distributions which satisfy
MTP2.
article_processing_charge: No
author:
- first_name: Shaun
full_name: Fallat, Shaun
last_name: Fallat
- first_name: Steffen
full_name: Lauritzen, Steffen
last_name: Lauritzen
- first_name: Kayvan
full_name: Sadeghi, Kayvan
last_name: Sadeghi
- first_name: Caroline
full_name: Uhler, Caroline
id: 49ADD78E-F248-11E8-B48F-1D18A9856A87
last_name: Uhler
orcid: 0000-0002-7008-0216
- first_name: Nanny
full_name: Wermuth, Nanny
last_name: Wermuth
- first_name: Piotr
full_name: Zwiernik, Piotr
last_name: Zwiernik
citation:
ama: Fallat S, Lauritzen S, Sadeghi K, Uhler C, Wermuth N, Zwiernik P. Total positivity
in Markov structures. Annals of Statistics. 2017;45(3):1152-1184. doi:10.1214/16-AOS1478
apa: Fallat, S., Lauritzen, S., Sadeghi, K., Uhler, C., Wermuth, N., & Zwiernik,
P. (2017). Total positivity in Markov structures. Annals of Statistics.
Institute of Mathematical Statistics. https://doi.org/10.1214/16-AOS1478
chicago: Fallat, Shaun, Steffen Lauritzen, Kayvan Sadeghi, Caroline Uhler, Nanny
Wermuth, and Piotr Zwiernik. “Total Positivity in Markov Structures.” Annals
of Statistics. Institute of Mathematical Statistics, 2017. https://doi.org/10.1214/16-AOS1478.
ieee: S. Fallat, S. Lauritzen, K. Sadeghi, C. Uhler, N. Wermuth, and P. Zwiernik,
“Total positivity in Markov structures,” Annals of Statistics, vol. 45,
no. 3. Institute of Mathematical Statistics, pp. 1152–1184, 2017.
ista: Fallat S, Lauritzen S, Sadeghi K, Uhler C, Wermuth N, Zwiernik P. 2017. Total
positivity in Markov structures. Annals of Statistics. 45(3), 1152–1184.
mla: Fallat, Shaun, et al. “Total Positivity in Markov Structures.” Annals of
Statistics, vol. 45, no. 3, Institute of Mathematical Statistics, 2017, pp.
1152–84, doi:10.1214/16-AOS1478.
short: S. Fallat, S. Lauritzen, K. Sadeghi, C. Uhler, N. Wermuth, P. Zwiernik, Annals
of Statistics 45 (2017) 1152–1184.
date_created: 2018-12-11T11:50:05Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2023-09-20T11:46:53Z
day: '01'
department:
- _id: CaUh
doi: 10.1214/16-AOS1478
external_id:
isi:
- '000404395900008'
intvolume: ' 45'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1510.01290
month: '06'
oa: 1
oa_version: Submitted Version
page: 1152 - 1184
project:
- _id: 2530CA10-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y 903-N35
name: 'Gaussian Graphical Models: Theory and Applications'
publication: Annals of Statistics
publication_identifier:
issn:
- '00905364'
publication_status: published
publisher: Institute of Mathematical Statistics
publist_id: '6288'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Total positivity in Markov structures
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 45
year: '2017'
...
---
_id: '1104'
abstract:
- lang: eng
text: In the early visual system, cells of the same type perform the same computation
in different places of the visual field. How these cells code together a complex
visual scene is unclear. A common assumption is that cells of a single-type extract
a single-stimulus feature to form a feature map, but this has rarely been observed
directly. Using large-scale recordings in the rat retina, we show that a homogeneous
population of fast OFF ganglion cells simultaneously encodes two radically different
features of a visual scene. Cells close to a moving object code quasilinearly
for its position, while distant cells remain largely invariant to the object's
position and, instead, respond nonlinearly to changes in the object's speed. We
develop a quantitative model that accounts for this effect and identify a disinhibitory
circuit that mediates it. Ganglion cells of a single type thus do not code for
one, but two features simultaneously. This richer, flexible neural map might also
be present in other sensory systems.
article_number: '1964'
article_processing_charge: No
author:
- first_name: Stephane
full_name: Deny, Stephane
last_name: Deny
- first_name: Ulisse
full_name: Ferrari, Ulisse
last_name: Ferrari
- first_name: Emilie
full_name: Mace, Emilie
last_name: Mace
- first_name: Pierre
full_name: Yger, Pierre
last_name: Yger
- first_name: Romain
full_name: Caplette, Romain
last_name: Caplette
- first_name: Serge
full_name: Picaud, Serge
last_name: Picaud
- first_name: Gasper
full_name: Tkacik, Gasper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkacik
orcid: 0000-0002-6699-1455
- first_name: Olivier
full_name: Marre, Olivier
last_name: Marre
citation:
ama: Deny S, Ferrari U, Mace E, et al. Multiplexed computations in retinal ganglion
cells of a single type. Nature Communications. 2017;8(1). doi:10.1038/s41467-017-02159-y
apa: Deny, S., Ferrari, U., Mace, E., Yger, P., Caplette, R., Picaud, S., … Marre,
O. (2017). Multiplexed computations in retinal ganglion cells of a single type.
Nature Communications. Nature Publishing Group. https://doi.org/10.1038/s41467-017-02159-y
chicago: Deny, Stephane, Ulisse Ferrari, Emilie Mace, Pierre Yger, Romain Caplette,
Serge Picaud, Gašper Tkačik, and Olivier Marre. “Multiplexed Computations in Retinal
Ganglion Cells of a Single Type.” Nature Communications. Nature Publishing
Group, 2017. https://doi.org/10.1038/s41467-017-02159-y.
ieee: S. Deny et al., “Multiplexed computations in retinal ganglion cells
of a single type,” Nature Communications, vol. 8, no. 1. Nature Publishing
Group, 2017.
ista: Deny S, Ferrari U, Mace E, Yger P, Caplette R, Picaud S, Tkačik G, Marre O.
2017. Multiplexed computations in retinal ganglion cells of a single type. Nature
Communications. 8(1), 1964.
mla: Deny, Stephane, et al. “Multiplexed Computations in Retinal Ganglion Cells
of a Single Type.” Nature Communications, vol. 8, no. 1, 1964, Nature Publishing
Group, 2017, doi:10.1038/s41467-017-02159-y.
short: S. Deny, U. Ferrari, E. Mace, P. Yger, R. Caplette, S. Picaud, G. Tkačik,
O. Marre, Nature Communications 8 (2017).
date_created: 2018-12-11T11:50:10Z
date_published: 2017-12-06T00:00:00Z
date_updated: 2023-09-20T11:41:19Z
day: '06'
ddc:
- '571'
department:
- _id: GaTk
doi: 10.1038/s41467-017-02159-y
ec_funded: 1
external_id:
isi:
- '000417241200004'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:06Z
date_updated: 2018-12-12T10:16:06Z
file_id: '5191'
file_name: IST-2018-921-v1+1_s41467-017-02159-y.pdf
file_size: 2872887
relation: main_file
file_date_updated: 2018-12-12T10:16:06Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
issue: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 25CD3DD2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '604102'
name: Localization of ion channels and receptors by two and three-dimensional immunoelectron
microscopic approaches
- _id: 254D1A94-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 25651-N26
name: Sensitivity to higher-order statistics in natural scenes
publication: Nature Communications
publication_identifier:
issn:
- '20411723'
publication_status: published
publisher: Nature Publishing Group
publist_id: '6266'
pubrep_id: '921'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Multiplexed computations in retinal ganglion cells of a single type
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2017'
...
---
_id: '11065'
abstract:
- lang: eng
text: Premature aging disorders provide an opportunity to study the mechanisms that
drive aging. In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of
the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins.
We sought to investigate protein homeostasis in this disease. Here, we report
a widespread increase in protein turnover in HGPS-derived cells compared to normal
cells. We determine that global protein synthesis is elevated as a consequence
of activated nucleoli and enhanced ribosome biogenesis in HGPS-derived fibroblasts.
Depleting normal lamin A or inducing mutant lamin A expression are each sufficient
to drive nucleolar expansion. We further show that nucleolar size correlates with
donor age in primary fibroblasts derived from healthy individuals and that ribosomal
RNA production increases with age, indicating that nucleolar size and activity
can serve as aging biomarkers. While limiting ribosome biogenesis extends lifespan
in several systems, we show that increased ribosome biogenesis and activity are
a hallmark of premature aging.
article_number: '328'
article_processing_charge: No
article_type: original
author:
- first_name: Abigail
full_name: Buchwalter, Abigail
last_name: Buchwalter
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Buchwalter A, Hetzer M. Nucleolar expansion and elevated protein translation
in premature aging. Nature Communications. 2017;8. doi:10.1038/s41467-017-00322-z
apa: Buchwalter, A., & Hetzer, M. (2017). Nucleolar expansion and elevated protein
translation in premature aging. Nature Communications. Springer Nature.
https://doi.org/10.1038/s41467-017-00322-z
chicago: Buchwalter, Abigail, and Martin Hetzer. “Nucleolar Expansion and Elevated
Protein Translation in Premature Aging.” Nature Communications. Springer
Nature, 2017. https://doi.org/10.1038/s41467-017-00322-z.
ieee: A. Buchwalter and M. Hetzer, “Nucleolar expansion and elevated protein translation
in premature aging,” Nature Communications, vol. 8. Springer Nature, 2017.
ista: Buchwalter A, Hetzer M. 2017. Nucleolar expansion and elevated protein translation
in premature aging. Nature Communications. 8, 328.
mla: Buchwalter, Abigail, and Martin Hetzer. “Nucleolar Expansion and Elevated Protein
Translation in Premature Aging.” Nature Communications, vol. 8, 328, Springer
Nature, 2017, doi:10.1038/s41467-017-00322-z.
short: A. Buchwalter, M. Hetzer, Nature Communications 8 (2017).
date_created: 2022-04-07T07:45:50Z
date_published: 2017-08-30T00:00:00Z
date_updated: 2022-07-18T08:33:03Z
day: '30'
doi: 10.1038/s41467-017-00322-z
extern: '1'
external_id:
pmid:
- '28855503'
intvolume: ' 8'
keyword:
- General Physics and Astronomy
- General Biochemistry
- Genetics and Molecular Biology
- General Chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41467-017-00322-z
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
issn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nucleolar expansion and elevated protein translation in premature aging
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 8
year: '2017'
...
---
_id: '11066'
abstract:
- lang: eng
text: Recent studies have shown that a subset of nucleoporins (Nups) can detach
from the nuclear pore complex and move into the nuclear interior to regulate transcription.
One such dynamic Nup, called Nup98, has been implicated in gene activation in
healthy cells and has been shown to drive leukemogenesis when mutated in patients
with acute myeloid leukemia (AML). Here we show that in hematopoietic cells, Nup98
binds predominantly to transcription start sites to recruit the Wdr82–Set1A/COMPASS
(complex of proteins associated with Set1) complex, which is required for deposition
of the histone 3 Lys4 trimethyl (H3K4me3)-activating mark. Depletion of Nup98
or Wdr82 abolishes Set1A recruitment to chromatin and subsequently ablates H3K4me3
at adjacent promoters. Furthermore, expression of a Nup98 fusion protein implicated
in aggressive AML causes mislocalization of H3K4me3 at abnormal regions and up-regulation
of associated genes. Our findings establish a function of Nup98 in hematopoietic
gene activation and provide mechanistic insight into which Nup98 leukemic fusion
proteins promote AML.
article_processing_charge: No
article_type: original
author:
- first_name: Tobias M.
full_name: Franks, Tobias M.
last_name: Franks
- first_name: Asako
full_name: McCloskey, Asako
last_name: McCloskey
- first_name: Maxim Nikolaievich
full_name: Shokhirev, Maxim Nikolaievich
last_name: Shokhirev
- first_name: Chris
full_name: Benner, Chris
last_name: Benner
- first_name: Annie
full_name: Rathore, Annie
last_name: Rathore
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
citation:
ama: Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. Nup98
recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation
in hematopoietic progenitor cells. Genes & Development. 2017;31(22):2222-2234.
doi:10.1101/gad.306753.117
apa: Franks, T. M., McCloskey, A., Shokhirev, M. N., Benner, C., Rathore, A., &
Hetzer, M. (2017). Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters
to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes &
Development. Cold Spring Harbor Laboratory. https://doi.org/10.1101/gad.306753.117
chicago: Franks, Tobias M., Asako McCloskey, Maxim Nikolaievich Shokhirev, Chris
Benner, Annie Rathore, and Martin Hetzer. “Nup98 Recruits the Wdr82–Set1A/COMPASS
Complex to Promoters to Regulate H3K4 Trimethylation in Hematopoietic Progenitor
Cells.” Genes & Development. Cold Spring Harbor Laboratory, 2017. https://doi.org/10.1101/gad.306753.117.
ieee: T. M. Franks, A. McCloskey, M. N. Shokhirev, C. Benner, A. Rathore, and M.
Hetzer, “Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate
H3K4 trimethylation in hematopoietic progenitor cells,” Genes & Development,
vol. 31, no. 22. Cold Spring Harbor Laboratory, pp. 2222–2234, 2017.
ista: Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. 2017.
Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation
in hematopoietic progenitor cells. Genes & Development. 31(22), 2222–2234.
mla: Franks, Tobias M., et al. “Nup98 Recruits the Wdr82–Set1A/COMPASS Complex to
Promoters to Regulate H3K4 Trimethylation in Hematopoietic Progenitor Cells.”
Genes & Development, vol. 31, no. 22, Cold Spring Harbor Laboratory,
2017, pp. 2222–34, doi:10.1101/gad.306753.117.
short: T.M. Franks, A. McCloskey, M.N. Shokhirev, C. Benner, A. Rathore, M. Hetzer,
Genes & Development 31 (2017) 2222–2234.
date_created: 2022-04-07T07:45:59Z
date_published: 2017-12-21T00:00:00Z
date_updated: 2022-07-18T08:33:05Z
day: '21'
doi: 10.1101/gad.306753.117
extern: '1'
external_id:
pmid:
- '29269482'
intvolume: ' 31'
issue: '22'
keyword:
- Developmental Biology
- Genetics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/gad.306753.117
month: '12'
oa: 1
oa_version: Published Version
page: 2222-2234
pmid: 1
publication: Genes & Development
publication_identifier:
issn:
- 0890-9369
- 1549-5477
publication_status: published
publisher: Cold Spring Harbor Laboratory
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4
trimethylation in hematopoietic progenitor cells
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 31
year: '2017'
...
---
_id: '11067'
abstract:
- lang: eng
text: Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that
changes during differentiation. Nucleoporins are linked with cell-type-specific
gene regulation, coupling physical changes in nuclear structure to transcriptional
output; but, whether and how they coordinate with key fate-determining transcription
factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2
in adult NeuPCs, where it is indispensable for their maintenance and controls
neuronal differentiation. Genome-wide analyses show that Nup153 and Sox2 bind
and co-regulate hundreds of genes. Binding of Nup153 to gene promoters or transcriptional
end sites correlates with increased or decreased gene expression, respectively,
and inhibiting Nup153 expression alters open chromatin configurations at its target
genes, disrupts genomic localization of Sox2, and promotes differentiation in
vitro and a gliogenic fate switch in vivo. Together, these findings reveal that
nuclear structural proteins may exert bimodal transcriptional effects to control
cell fate.
article_processing_charge: No
article_type: original
author:
- first_name: Tomohisa
full_name: Toda, Tomohisa
last_name: Toda
- first_name: Jonathan Y.
full_name: Hsu, Jonathan Y.
last_name: Hsu
- first_name: Sara B.
full_name: Linker, Sara B.
last_name: Linker
- first_name: Lauren
full_name: Hu, Lauren
last_name: Hu
- first_name: Simon T.
full_name: Schafer, Simon T.
last_name: Schafer
- first_name: Jerome
full_name: Mertens, Jerome
last_name: Mertens
- first_name: Filipe V.
full_name: Jacinto, Filipe V.
last_name: Jacinto
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Fred H.
full_name: Gage, Fred H.
last_name: Gage
citation:
ama: Toda T, Hsu JY, Linker SB, et al. Nup153 interacts with Sox2 to enable bimodal
gene regulation and maintenance of neural progenitor cells. Cell Stem Cell.
2017;21(5):618-634.e7. doi:10.1016/j.stem.2017.08.012
apa: Toda, T., Hsu, J. Y., Linker, S. B., Hu, L., Schafer, S. T., Mertens, J., …
Gage, F. H. (2017). Nup153 interacts with Sox2 to enable bimodal gene regulation
and maintenance of neural progenitor cells. Cell Stem Cell. Elsevier. https://doi.org/10.1016/j.stem.2017.08.012
chicago: Toda, Tomohisa, Jonathan Y. Hsu, Sara B. Linker, Lauren Hu, Simon T. Schafer,
Jerome Mertens, Filipe V. Jacinto, Martin Hetzer, and Fred H. Gage. “Nup153 Interacts
with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor
Cells.” Cell Stem Cell. Elsevier, 2017. https://doi.org/10.1016/j.stem.2017.08.012.
ieee: T. Toda et al., “Nup153 interacts with Sox2 to enable bimodal gene
regulation and maintenance of neural progenitor cells,” Cell Stem Cell,
vol. 21, no. 5. Elsevier, p. 618–634.e7, 2017.
ista: Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer
M, Gage FH. 2017. Nup153 interacts with Sox2 to enable bimodal gene regulation
and maintenance of neural progenitor cells. Cell Stem Cell. 21(5), 618–634.e7.
mla: Toda, Tomohisa, et al. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation
and Maintenance of Neural Progenitor Cells.” Cell Stem Cell, vol. 21, no.
5, Elsevier, 2017, p. 618–634.e7, doi:10.1016/j.stem.2017.08.012.
short: T. Toda, J.Y. Hsu, S.B. Linker, L. Hu, S.T. Schafer, J. Mertens, F.V. Jacinto,
M. Hetzer, F.H. Gage, Cell Stem Cell 21 (2017) 618–634.e7.
date_created: 2022-04-07T07:46:12Z
date_published: 2017-11-02T00:00:00Z
date_updated: 2022-07-18T08:33:07Z
day: '02'
doi: 10.1016/j.stem.2017.08.012
extern: '1'
external_id:
pmid:
- '28919367'
intvolume: ' 21'
issue: '5'
keyword:
- Cell Biology
- Genetics
- Molecular Medicine
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.stem.2017.08.012
month: '11'
oa: 1
oa_version: Published Version
page: 618-634.e7
pmid: 1
publication: Cell Stem Cell
publication_identifier:
issn:
- 1934-5909
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance
of neural progenitor cells
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 21
year: '2017'
...
---
_id: '1107'
abstract:
- lang: eng
text: The generation, migration, and differentiation of neurons requires the functional
integrity of the microtubule cytoskeleton. Mutations in the tubulin gene family
are known to cause various neurological diseases including lissencephaly, ocular
motor disorders, polymicrogyria and amyotrophic lateral sclerosis. We have previously
reported that mutations in TUBB5 cause microcephaly that is accompanied by severe
intellectual impairment and motor delay. Here we present the characterization
of a Tubb5 mouse model that allows for the conditional expression of the pathogenic
E401K mutation. Homozygous knockin animals exhibit a severe reduction in brain
size and in body weight. These animals do not show any significant impairment
in general activity, anxiety, or in the acoustic startle response, however, present
with notable defects in motor coordination. When assessed on the static rod apparatus
mice took longer to orient and often lost their balance completely. Interestingly,
mutant animals also showed defects in prepulse inhibition, a phenotype associated
with sensorimotor gating and considered an endophenotype for schizophrenia. This
study provides insight into the behavioral consequences of tubulin gene mutations.
acknowledgement: Austrian Science Fund (FWF) for funding this research [I914,P21092]
article_processing_charge: No
author:
- first_name: Martin
full_name: Breuss, Martin
last_name: Breuss
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: Lukas
full_name: Landler, Lukas
last_name: Landler
- first_name: David
full_name: Keays, David
last_name: Keays
citation:
ama: Breuss M, Hansen AH, Landler L, Keays D. Brain specific knockin of the pathogenic
Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition.
Behavioural Brain Research. 2017;323:47-55. doi:10.1016/j.bbr.2017.01.029
apa: Breuss, M., Hansen, A. H., Landler, L., & Keays, D. (2017). Brain specific
knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination
and prepulse inhibition. Behavioural Brain Research. Elsevier. https://doi.org/10.1016/j.bbr.2017.01.029
chicago: Breuss, Martin, Andi H Hansen, Lukas Landler, and David Keays. “Brain Specific
Knockin of the Pathogenic Tubb5 E401K Allele Causes Defects in Motor Coordination
and Prepulse Inhibition.” Behavioural Brain Research. Elsevier, 2017. https://doi.org/10.1016/j.bbr.2017.01.029.
ieee: M. Breuss, A. H. Hansen, L. Landler, and D. Keays, “Brain specific knockin
of the pathogenic Tubb5 E401K allele causes defects in motor coordination and
prepulse inhibition,” Behavioural Brain Research, vol. 323. Elsevier, pp.
47–55, 2017.
ista: Breuss M, Hansen AH, Landler L, Keays D. 2017. Brain specific knockin of the
pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse
inhibition. Behavioural Brain Research. 323, 47–55.
mla: Breuss, Martin, et al. “Brain Specific Knockin of the Pathogenic Tubb5 E401K
Allele Causes Defects in Motor Coordination and Prepulse Inhibition.” Behavioural
Brain Research, vol. 323, Elsevier, 2017, pp. 47–55, doi:10.1016/j.bbr.2017.01.029.
short: M. Breuss, A.H. Hansen, L. Landler, D. Keays, Behavioural Brain Research
323 (2017) 47–55.
date_created: 2018-12-11T11:50:11Z
date_published: 2017-04-14T00:00:00Z
date_updated: 2023-09-20T11:37:25Z
day: '14'
ddc:
- '570'
- '571'
doi: 10.1016/j.bbr.2017.01.029
extern: '1'
external_id:
isi:
- '000397369100007'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:12:03Z
date_updated: 2018-12-12T10:12:03Z
file_id: '4921'
file_name: IST-2017-868-v1+1_1-s2.0-S0166432816309160-main.pdf
file_size: 2291511
relation: main_file
file_date_updated: 2018-12-12T10:12:03Z
has_accepted_license: '1'
intvolume: ' 323'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '04'
oa: 1
oa_version: Published Version
page: 47 - 55
publication: Behavioural Brain Research
publication_identifier:
issn:
- '01664328'
publication_status: published
publisher: Elsevier
publist_id: '6262'
pubrep_id: '868'
quality_controlled: '1'
status: public
title: Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects
in motor coordination and prepulse inhibition
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 323
year: '2017'
...