---
_id: '7416'
abstract:
- lang: eng
text: Earlier, we demonstrated that transcript levels of METAL TOLERANCE PROTEIN2
(MTP2) and of HEAVY METAL ATPase2 (HMA2) increase strongly in roots of Arabidopsis
upon prolonged zinc (Zn) deficiency and respond to shoot physiological Zn status,
and not to the local Zn status in roots. This provided evidence for shoot-to-root
communication in the acclimation of plants to Zn deficiency. Zn-deficient soils
limit both the yield and quality of agricultural crops and can result in clinically
relevant nutritional Zn deficiency in human populations. Implementing Zn deficiency
during cultivation of the model plant Arabidopsis thaliana on agar-solidified
media is difficult because trace element contaminations are present in almost
all commercially available agars. Here, we demonstrate root morphological acclimations
to Zn deficiency on agar-solidified medium following the effective removal of
contaminants. These advancements allow reproducible phenotyping toward understanding
fundamental plant responses to deficiencies of Zn and other essential trace elements.
article_number: '1687175'
article_processing_charge: No
article_type: original
author:
- first_name: Scott A
full_name: Sinclair, Scott A
id: 2D99FE6A-F248-11E8-B48F-1D18A9856A87
last_name: Sinclair
orcid: 0000-0002-4566-0593
- first_name: U.
full_name: Krämer, U.
last_name: Krämer
citation:
ama: Sinclair SA, Krämer U. Generation of effective zinc-deficient agar-solidified
media allows identification of root morphology changes in response to zinc limitation.
Plant Signaling & Behavior. 2020;15(1). doi:10.1080/15592324.2019.1687175
apa: Sinclair, S. A., & Krämer, U. (2020). Generation of effective zinc-deficient
agar-solidified media allows identification of root morphology changes in response
to zinc limitation. Plant Signaling & Behavior. Taylor & Francis.
https://doi.org/10.1080/15592324.2019.1687175
chicago: Sinclair, Scott A, and U. Krämer. “Generation of Effective Zinc-Deficient
Agar-Solidified Media Allows Identification of Root Morphology Changes in Response
to Zinc Limitation.” Plant Signaling & Behavior. Taylor & Francis,
2020. https://doi.org/10.1080/15592324.2019.1687175.
ieee: S. A. Sinclair and U. Krämer, “Generation of effective zinc-deficient agar-solidified
media allows identification of root morphology changes in response to zinc limitation,”
Plant Signaling & Behavior, vol. 15, no. 1. Taylor & Francis, 2020.
ista: Sinclair SA, Krämer U. 2020. Generation of effective zinc-deficient agar-solidified
media allows identification of root morphology changes in response to zinc limitation.
Plant Signaling & Behavior. 15(1), 1687175.
mla: Sinclair, Scott A., and U. Krämer. “Generation of Effective Zinc-Deficient
Agar-Solidified Media Allows Identification of Root Morphology Changes in Response
to Zinc Limitation.” Plant Signaling & Behavior, vol. 15, no. 1, 1687175,
Taylor & Francis, 2020, doi:10.1080/15592324.2019.1687175.
short: S.A. Sinclair, U. Krämer, Plant Signaling & Behavior 15 (2020).
date_created: 2020-01-30T10:12:04Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2023-10-17T09:01:48Z
day: '01'
department:
- _id: JiFr
doi: 10.1080/15592324.2019.1687175
external_id:
isi:
- '000494909300001'
pmid:
- '31696764'
intvolume: ' 15'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012054
month: '01'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: Plant Signaling & Behavior
publication_identifier:
issn:
- 1559-2324
publication_status: published
publisher: Taylor & Francis
quality_controlled: '1'
scopus_import: '1'
status: public
title: Generation of effective zinc-deficient agar-solidified media allows identification
of root morphology changes in response to zinc limitation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2020'
...
---
_id: '7417'
abstract:
- lang: eng
text: Previously, we reported that the allelic de-etiolated by zinc (dez) and trichome
birefringence (tbr) mutants exhibit photomorphogenic development in the dark,
which is enhanced by high Zn. TRICHOME BIREFRINGENCE-LIKE proteins had been implicated
in transferring acetyl groups to various hemicelluloses. Pectin O-acetylation
levels were lower in dark-grown dez seedlings than in the wild type. We observed
Zn-enhanced photomorphogenesis in the dark also in the reduced wall acetylation
2 (rwa2-3) mutant, which exhibits lowered O-acetylation levels of cell wall macromolecules
including pectins and xyloglucans, supporting a role for cell wall macromolecule
O-acetylation in the photomorphogenic phenotypes of rwa2-3 and dez. Application
of very short oligogalacturonides (vsOGs) restored skotomorphogenesis in dark-grown
dez and rwa2-3. Here we demonstrate that in dez, O-acetylation of non-pectin cell
wall components, notably of xyloglucan, is enhanced. Our results highlight the
complexity of cell wall homeostasis and indicate against an influence of xyloglucan
O-acetylation on light-dependent seedling development.
article_number: e1687185
article_processing_charge: No
article_type: original
author:
- first_name: Scott A
full_name: Sinclair, Scott A
id: 2D99FE6A-F248-11E8-B48F-1D18A9856A87
last_name: Sinclair
orcid: 0000-0002-4566-0593
- first_name: S.
full_name: Gille, S.
last_name: Gille
- first_name: M.
full_name: Pauly, M.
last_name: Pauly
- first_name: U.
full_name: Krämer, U.
last_name: Krämer
citation:
ama: Sinclair SA, Gille S, Pauly M, Krämer U. Regulation of acetylation of plant
cell wall components is complex and responds to external stimuli. Plant Signaling
& Behavior. 2020;15(1). doi:10.1080/15592324.2019.1687185
apa: Sinclair, S. A., Gille, S., Pauly, M., & Krämer, U. (2020). Regulation
of acetylation of plant cell wall components is complex and responds to external
stimuli. Plant Signaling & Behavior. Informa UK Limited. https://doi.org/10.1080/15592324.2019.1687185
chicago: Sinclair, Scott A, S. Gille, M. Pauly, and U. Krämer. “Regulation of Acetylation
of Plant Cell Wall Components Is Complex and Responds to External Stimuli.” Plant
Signaling & Behavior. Informa UK Limited, 2020. https://doi.org/10.1080/15592324.2019.1687185.
ieee: S. A. Sinclair, S. Gille, M. Pauly, and U. Krämer, “Regulation of acetylation
of plant cell wall components is complex and responds to external stimuli,” Plant
Signaling & Behavior, vol. 15, no. 1. Informa UK Limited, 2020.
ista: Sinclair SA, Gille S, Pauly M, Krämer U. 2020. Regulation of acetylation of
plant cell wall components is complex and responds to external stimuli. Plant
Signaling & Behavior. 15(1), e1687185.
mla: Sinclair, Scott A., et al. “Regulation of Acetylation of Plant Cell Wall Components
Is Complex and Responds to External Stimuli.” Plant Signaling & Behavior,
vol. 15, no. 1, e1687185, Informa UK Limited, 2020, doi:10.1080/15592324.2019.1687185.
short: S.A. Sinclair, S. Gille, M. Pauly, U. Krämer, Plant Signaling & Behavior
15 (2020).
date_created: 2020-01-30T10:14:14Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2023-09-06T15:23:04Z
day: '01'
department:
- _id: JiFr
doi: 10.1080/15592324.2019.1687185
external_id:
isi:
- '000494907500001'
pmid:
- '31696770'
intvolume: ' 15'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7012154
month: '01'
oa: 1
oa_version: Submitted Version
pmid: 1
publication: Plant Signaling & Behavior
publication_identifier:
issn:
- 1559-2324
publication_status: published
publisher: Informa UK Limited
quality_controlled: '1'
scopus_import: '1'
status: public
title: Regulation of acetylation of plant cell wall components is complex and responds
to external stimuli
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 15
year: '2020'
...
---
_id: '7426'
abstract:
- lang: eng
text: This paper presents a novel abstraction technique for analyzing Lyapunov and
asymptotic stability of polyhedral switched systems. A polyhedral switched system
is a hybrid system in which the continuous dynamics is specified by polyhedral
differential inclusions, the invariants and guards are specified by polyhedral
sets and the switching between the modes do not involve reset of variables. A
finite state weighted graph abstracting the polyhedral switched system is constructed
from a finite partition of the state–space, such that the satisfaction of certain
graph conditions, such as the absence of cycles with product of weights on the
edges greater than (or equal) to 1, implies the stability of the system. However,
the graph is in general conservative and hence, the violation of the graph conditions
does not imply instability. If the analysis fails to establish stability due to
the conservativeness in the approximation, a counterexample (cycle with product
of edge weights greater than or equal to 1) indicating a potential reason for
the failure is returned. Further, a more precise approximation of the switched
system can be constructed by considering a finer partition of the state–space
in the construction of the finite weighted graph. We present experimental results
on analyzing stability of switched systems using the above method.
article_number: '100856'
article_processing_charge: No
article_type: original
author:
- first_name: Miriam
full_name: Garcia Soto, Miriam
id: 4B3207F6-F248-11E8-B48F-1D18A9856A87
last_name: Garcia Soto
orcid: 0000−0003−2936−5719
- first_name: Pavithra
full_name: Prabhakar, Pavithra
last_name: Prabhakar
citation:
ama: 'Garcia Soto M, Prabhakar P. Abstraction based verification of stability of
polyhedral switched systems. Nonlinear Analysis: Hybrid Systems. 2020;36(5).
doi:10.1016/j.nahs.2020.100856'
apa: 'Garcia Soto, M., & Prabhakar, P. (2020). Abstraction based verification
of stability of polyhedral switched systems. Nonlinear Analysis: Hybrid Systems.
Elsevier. https://doi.org/10.1016/j.nahs.2020.100856'
chicago: 'Garcia Soto, Miriam, and Pavithra Prabhakar. “Abstraction Based Verification
of Stability of Polyhedral Switched Systems.” Nonlinear Analysis: Hybrid Systems.
Elsevier, 2020. https://doi.org/10.1016/j.nahs.2020.100856.'
ieee: 'M. Garcia Soto and P. Prabhakar, “Abstraction based verification of stability
of polyhedral switched systems,” Nonlinear Analysis: Hybrid Systems, vol.
36, no. 5. Elsevier, 2020.'
ista: 'Garcia Soto M, Prabhakar P. 2020. Abstraction based verification of stability
of polyhedral switched systems. Nonlinear Analysis: Hybrid Systems. 36(5), 100856.'
mla: 'Garcia Soto, Miriam, and Pavithra Prabhakar. “Abstraction Based Verification
of Stability of Polyhedral Switched Systems.” Nonlinear Analysis: Hybrid Systems,
vol. 36, no. 5, 100856, Elsevier, 2020, doi:10.1016/j.nahs.2020.100856.'
short: 'M. Garcia Soto, P. Prabhakar, Nonlinear Analysis: Hybrid Systems 36 (2020).'
date_created: 2020-02-02T23:00:59Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2023-08-17T14:32:54Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1016/j.nahs.2020.100856
external_id:
isi:
- '000528828600003'
file:
- access_level: open_access
checksum: 560abfddb53f9fe921b6744f59f2cfaa
content_type: application/pdf
creator: dernst
date_created: 2020-10-21T13:16:45Z
date_updated: 2022-05-16T22:30:04Z
embargo: 2022-05-15
file_id: '8688'
file_name: 2020_NAHS_GarciaSoto.pdf
file_size: 818774
relation: main_file
file_date_updated: 2022-05-16T22:30:04Z
has_accepted_license: '1'
intvolume: ' 36'
isi: 1
issue: '5'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '05'
oa: 1
oa_version: Submitted Version
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
publication: 'Nonlinear Analysis: Hybrid Systems'
publication_identifier:
issn:
- 1751-570X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Abstraction based verification of stability of polyhedral switched systems
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 36
year: '2020'
...
---
_id: '7427'
abstract:
- lang: eng
text: Plants, like other multicellular organisms, survive through a delicate balance
between growth and defense against pathogens. Salicylic acid (SA) is a major defense
signal in plants, and the perception mechanism as well as downstream signaling
activating the immune response are known. Here, we identify a parallel SA signaling
that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase
2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin
transporter is hyperphosphorylated in response to SA, leading to changed activity
of this important growth regulator. Accordingly, auxin transport and auxin-mediated
root development, including growth, gravitropic response, and lateral root organogenesis,
are inhibited. This study reveals how SA, besides activating immunity, concomitantly
attenuates growth through crosstalk with the auxin distribution network. Further
analysis of this dual role of SA and characterization of additional SA-regulated
PP2A targets will provide further insights into mechanisms maintaining a balance
between growth and defense.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: "We thank Shigeyuki Betsuyaku (University of Tsukuba), Alison Delong
(Brown University), Xinnian Dong (Duke University), Dolf Weijers (Wageningen University),
Yuelin Zhang (UBC), and Martine Pastuglia (Institut Jean-Pierre Bourgin) for sharing
published materials; Jana Riederer for help with cantharidin physiological analysis;
David Domjan for help with cloning pET28a-PIN2HL; Qing Lu for help with DARTS; Hana
Kozubı´kova´ for technical support on SA derivative synthesis; Zuzana Vondra´ kova´
for technical support with tobacco cells; Lucia Strader (Washington University),
Bert De Rybel (Ghent University), Bartel Vanholme (Ghent University), and Lukas
Mach (BOKU) for helpful discussions; and bioimaging and life science facilities
of IST Austria for continuous support. We gratefully acknowledge the Nottingham
Arabidopsis Stock Center (NASC) for providing T-DNA insertional mutants. The DSC
and SPR instruments were provided by the EQ-BOKU VIBT GmbH and the BOKU Core Facility
for Biomolecular and Cellular Analysis, with help of Irene Schaffner. The research
leading to these results has received funding from the European Union’s Horizon
2020 program (ERC grant agreement no. 742985 to J.F.) and the People Programme (Marie
Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013)
under REA grant agreement no. 291734. S.T. was supported by a European Molecular
Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 723-2015). O.N.
was supported by the Ministry of Education, Youth and Sports of the Czech Republic
(European Regional Development Fund-Project ‘‘Centre for Experimental Plant Biology’’
no. CZ.02.1.01/0.0/0.0/16_019/0000738). J. Pospısil was supported by European Regional
Development Fund Project ‘‘Centre for Experimental Plant Biology’’\r\n(no. CZ.02.1.01/0.0/0.0/16_019/0000738).
J. Petrasek was supported by EU Operational Programme Prague-Competitiveness (no.
CZ.2.16/3.1.00/21519). "
article_processing_charge: No
article_type: original
author:
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Melinda F
full_name: Abas, Melinda F
id: 3CFB3B1C-F248-11E8-B48F-1D18A9856A87
last_name: Abas
- first_name: Inge
full_name: Verstraeten, Inge
id: 362BF7FE-F248-11E8-B48F-1D18A9856A87
last_name: Verstraeten
orcid: 0000-0001-7241-2328
- first_name: Matous
full_name: Glanc, Matous
id: 1AE1EA24-02D0-11E9-9BAA-DAF4881429F2
last_name: Glanc
orcid: 0000-0003-0619-7783
- first_name: Gergely
full_name: Molnar, Gergely
id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
last_name: Molnar
- first_name: Jakub
full_name: Hajny, Jakub
id: 4800CC20-F248-11E8-B48F-1D18A9856A87
last_name: Hajny
orcid: 0000-0003-2140-7195
- first_name: Pavel
full_name: Lasák, Pavel
last_name: Lasák
- first_name: Ivan
full_name: Petřík, Ivan
last_name: Petřík
- first_name: Eugenia
full_name: Russinova, Eugenia
last_name: Russinova
- first_name: Jan
full_name: Petrášek, Jan
last_name: Petrášek
- first_name: Ondřej
full_name: Novák, Ondřej
last_name: Novák
- first_name: Jiří
full_name: Pospíšil, Jiří
last_name: Pospíšil
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Tan S, Abas MF, Verstraeten I, et al. Salicylic acid targets protein phosphatase
2A to attenuate growth in plants. Current Biology. 2020;30(3):381-395.e8.
doi:10.1016/j.cub.2019.11.058
apa: Tan, S., Abas, M. F., Verstraeten, I., Glanc, M., Molnar, G., Hajny, J., …
Friml, J. (2020). Salicylic acid targets protein phosphatase 2A to attenuate growth
in plants. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2019.11.058
chicago: Tan, Shutang, Melinda F Abas, Inge Verstraeten, Matous Glanc, Gergely Molnar,
Jakub Hajny, Pavel Lasák, et al. “Salicylic Acid Targets Protein Phosphatase 2A
to Attenuate Growth in Plants.” Current Biology. Cell Press, 2020. https://doi.org/10.1016/j.cub.2019.11.058.
ieee: S. Tan et al., “Salicylic acid targets protein phosphatase 2A to attenuate
growth in plants,” Current Biology, vol. 30, no. 3. Cell Press, p. 381–395.e8,
2020.
ista: Tan S, Abas MF, Verstraeten I, Glanc M, Molnar G, Hajny J, Lasák P, Petřík
I, Russinova E, Petrášek J, Novák O, Pospíšil J, Friml J. 2020. Salicylic acid
targets protein phosphatase 2A to attenuate growth in plants. Current Biology.
30(3), 381–395.e8.
mla: Tan, Shutang, et al. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate
Growth in Plants.” Current Biology, vol. 30, no. 3, Cell Press, 2020, p.
381–395.e8, doi:10.1016/j.cub.2019.11.058.
short: S. Tan, M.F. Abas, I. Verstraeten, M. Glanc, G. Molnar, J. Hajny, P. Lasák,
I. Petřík, E. Russinova, J. Petrášek, O. Novák, J. Pospíšil, J. Friml, Current
Biology 30 (2020) 381–395.e8.
date_created: 2020-02-02T23:01:00Z
date_published: 2020-02-03T00:00:00Z
date_updated: 2024-03-25T23:30:20Z
day: '03'
ddc:
- '580'
department:
- _id: JiFr
- _id: EvBe
doi: 10.1016/j.cub.2019.11.058
ec_funded: 1
external_id:
isi:
- '000511287900018'
pmid:
- '31956021'
file:
- access_level: open_access
checksum: 16f7d51fe28f91c21e4896a2028df40b
content_type: application/pdf
creator: dernst
date_created: 2020-09-22T09:51:28Z
date_updated: 2020-09-22T09:51:28Z
file_id: '8555'
file_name: 2020_CurrentBiology_Tan.pdf
file_size: 5360135
relation: main_file
success: 1
file_date_updated: 2020-09-22T09:51:28Z
has_accepted_license: '1'
intvolume: ' 30'
isi: 1
issue: '3'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: 381-395.e8
pmid: 1
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 256FEF10-B435-11E9-9278-68D0E5697425
grant_number: 723-2015
name: Long Term Fellowship
publication: Current Biology
publication_identifier:
issn:
- '09609822'
publication_status: published
publisher: Cell Press
quality_controlled: '1'
related_material:
record:
- id: '8822'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Salicylic acid targets protein phosphatase 2A to attenuate growth in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 30
year: '2020'
...
---
_id: '7428'
abstract:
- lang: eng
text: In the superconducting regime of FeTe(1−x)Sex, there exist two types of vortices
which are distinguished by the presence or absence of zero-energy states in their
core. To understand their origin, we examine the interplay of Zeeman coupling
and superconducting pairings in three-dimensional metals with band inversion.
Weak Zeeman fields are found to suppress intraorbital spin-singlet pairing, known
to localize the states at the ends of the vortices on the surface. On the other
hand, an orbital-triplet pairing is shown to be stable against Zeeman interactions,
but leads to delocalized zero-energy Majorana modes which extend through the vortex.
In contrast, the finite-energy vortex modes remain localized at the vortex ends
even when the pairing is of orbital-triplet form. Phenomenologically, this manifests
as an observed disappearance of zero-bias peaks within the cores of topological
vortices upon an increase of the applied magnetic field. The presence of magnetic
impurities in FeTe(1−x)Sex, which are attracted to the vortices, would lead to
such Zeeman-induced delocalization of Majorana modes in a fraction of vortices
that capture a large enough number of magnetic impurities. Our results provide
an explanation for the dichotomy between topological and nontopological vortices
recently observed in FeTe(1−x)Sex.
article_number: '020504'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Areg
full_name: Ghazaryan, Areg
id: 4AF46FD6-F248-11E8-B48F-1D18A9856A87
last_name: Ghazaryan
orcid: 0000-0001-9666-3543
- first_name: P. L.S.
full_name: Lopes, P. L.S.
last_name: Lopes
- first_name: Pavan
full_name: Hosur, Pavan
last_name: Hosur
- first_name: Matthew J.
full_name: Gilbert, Matthew J.
last_name: Gilbert
- first_name: Pouyan
full_name: Ghaemi, Pouyan
last_name: Ghaemi
citation:
ama: Ghazaryan A, Lopes PLS, Hosur P, Gilbert MJ, Ghaemi P. Effect of Zeeman coupling
on the Majorana vortex modes in iron-based topological superconductors. Physical
Review B. 2020;101(2). doi:10.1103/PhysRevB.101.020504
apa: Ghazaryan, A., Lopes, P. L. S., Hosur, P., Gilbert, M. J., & Ghaemi, P.
(2020). Effect of Zeeman coupling on the Majorana vortex modes in iron-based topological
superconductors. Physical Review B. American Physical Society. https://doi.org/10.1103/PhysRevB.101.020504
chicago: Ghazaryan, Areg, P. L.S. Lopes, Pavan Hosur, Matthew J. Gilbert, and Pouyan
Ghaemi. “Effect of Zeeman Coupling on the Majorana Vortex Modes in Iron-Based
Topological Superconductors.” Physical Review B. American Physical Society,
2020. https://doi.org/10.1103/PhysRevB.101.020504.
ieee: A. Ghazaryan, P. L. S. Lopes, P. Hosur, M. J. Gilbert, and P. Ghaemi, “Effect
of Zeeman coupling on the Majorana vortex modes in iron-based topological superconductors,”
Physical Review B, vol. 101, no. 2. American Physical Society, 2020.
ista: Ghazaryan A, Lopes PLS, Hosur P, Gilbert MJ, Ghaemi P. 2020. Effect of Zeeman
coupling on the Majorana vortex modes in iron-based topological superconductors.
Physical Review B. 101(2), 020504.
mla: Ghazaryan, Areg, et al. “Effect of Zeeman Coupling on the Majorana Vortex Modes
in Iron-Based Topological Superconductors.” Physical Review B, vol. 101,
no. 2, 020504, American Physical Society, 2020, doi:10.1103/PhysRevB.101.020504.
short: A. Ghazaryan, P.L.S. Lopes, P. Hosur, M.J. Gilbert, P. Ghaemi, Physical Review
B 101 (2020).
date_created: 2020-02-02T23:01:01Z
date_published: 2020-01-13T00:00:00Z
date_updated: 2024-02-28T13:11:13Z
day: '13'
department:
- _id: MiLe
doi: 10.1103/PhysRevB.101.020504
external_id:
arxiv:
- '1907.02077'
isi:
- '000506843500001'
intvolume: ' 101'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1907.02077
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
eissn:
- '24699969'
issn:
- '24699950'
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Effect of Zeeman coupling on the Majorana vortex modes in iron-based topological
superconductors
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 101
year: '2020'
...
---
_id: '7431'
abstract:
- lang: eng
text: 'In many real-world systems, information can be transmitted in two qualitatively
different ways: by copying or by transformation. Copying occurs when messages
are transmitted without modification, e.g. when an offspring receives an unaltered
copy of a gene from its parent. Transformation occurs when messages are modified
systematically during transmission, e.g. when mutational biases occur during genetic
replication. Standard information-theoretic measures do not distinguish these
two modes of information transfer, although they may reflect different mechanisms
and have different functional consequences. Starting from a few simple axioms,
we derive a decomposition of mutual information into the information transmitted
by copying versus the information transmitted by transformation. We begin with
a decomposition that applies when the source and destination of the channel have
the same set of messages and a notion of message identity exists. We then generalize
our decomposition to other kinds of channels, which can involve different source
and destination sets and broader notions of similarity. In addition, we show that
copy information can be interpreted as the minimal work needed by a physical copying
process, which is relevant for understanding the physics of replication. We use
the proposed decomposition to explore a model of amino acid substitution rates.
Our results apply to any system in which the fidelity of copying, rather than
simple predictability, is of critical relevance.'
acknowledgement: "AK was supported by Grant No. FQXi-RFP-1622 from the FQXi foundation,
and Grant No. CHE-1648973 from the U.S.\r\nNational Science Foundation. AK would
like to thank the Santa Fe Institute for supporting this research. The authors\r\nthank
Jordi Fortuny, Rudolf Hanel, Joshua Garland, and Blai Vidiella for helpful discussions,
as well as the anonymous\r\nreviewers for their insightful suggestions. "
article_number: '0623'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Artemy
full_name: Kolchinsky, Artemy
last_name: Kolchinsky
- first_name: Bernat
full_name: Corominas-Murtra, Bernat
id: 43BE2298-F248-11E8-B48F-1D18A9856A87
last_name: Corominas-Murtra
orcid: 0000-0001-9806-5643
citation:
ama: Kolchinsky A, Corominas-Murtra B. Decomposing information into copying versus
transformation. Journal of the Royal Society Interface. 2020;17(162). doi:10.1098/rsif.2019.0623
apa: Kolchinsky, A., & Corominas-Murtra, B. (2020). Decomposing information
into copying versus transformation. Journal of the Royal Society Interface.
The Royal Society. https://doi.org/10.1098/rsif.2019.0623
chicago: Kolchinsky, Artemy, and Bernat Corominas-Murtra. “Decomposing Information
into Copying versus Transformation.” Journal of the Royal Society Interface.
The Royal Society, 2020. https://doi.org/10.1098/rsif.2019.0623.
ieee: A. Kolchinsky and B. Corominas-Murtra, “Decomposing information into copying
versus transformation,” Journal of the Royal Society Interface, vol. 17,
no. 162. The Royal Society, 2020.
ista: Kolchinsky A, Corominas-Murtra B. 2020. Decomposing information into copying
versus transformation. Journal of the Royal Society Interface. 17(162), 0623.
mla: Kolchinsky, Artemy, and Bernat Corominas-Murtra. “Decomposing Information into
Copying versus Transformation.” Journal of the Royal Society Interface,
vol. 17, no. 162, 0623, The Royal Society, 2020, doi:10.1098/rsif.2019.0623.
short: A. Kolchinsky, B. Corominas-Murtra, Journal of the Royal Society Interface
17 (2020).
date_created: 2020-02-02T23:01:03Z
date_published: 2020-01-29T00:00:00Z
date_updated: 2023-08-17T14:31:28Z
day: '29'
department:
- _id: EdHa
doi: 10.1098/rsif.2019.0623
external_id:
arxiv:
- '1903.10693'
isi:
- '000538369800002'
pmid:
- '31964273'
intvolume: ' 17'
isi: 1
issue: '162'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1903.10693
month: '01'
oa: 1
oa_version: Preprint
pmid: 1
publication: Journal of the Royal Society Interface
publication_identifier:
eissn:
- '17425662'
publication_status: published
publisher: The Royal Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Decomposing information into copying versus transformation
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2020'
...
---
_id: '7460'
abstract:
- lang: eng
text: "Many methods for the reconstruction of shapes from sets of points produce
ordered simplicial complexes, which are collections of vertices, edges, triangles,
and their higher-dimensional analogues, called simplices, in which every simplex
gets assigned a real value measuring its size. This thesis studies ordered simplicial
complexes, with a focus on their topology, which reflects the connectedness of
the represented shapes and the presence of holes. We are interested both in understanding
better the structure of these complexes, as well as in developing algorithms for
applications.\r\n\r\nFor the Delaunay triangulation, the most popular measure
for a simplex is the radius of the smallest empty circumsphere. Based on it, we
revisit Alpha and Wrap complexes and experimentally determine their probabilistic
properties for random data. Also, we prove the existence of tri-partitions, propose
algorithms to open and close holes, and extend the concepts from Euclidean to
Bregman geometries."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Katharina
full_name: Ölsböck, Katharina
id: 4D4AA390-F248-11E8-B48F-1D18A9856A87
last_name: Ölsböck
orcid: 0000-0002-4672-8297
citation:
ama: Ölsböck K. The hole system of triangulated shapes. 2020. doi:10.15479/AT:ISTA:7460
apa: Ölsböck, K. (2020). The hole system of triangulated shapes. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7460
chicago: Ölsböck, Katharina. “The Hole System of Triangulated Shapes.” Institute
of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:7460.
ieee: K. Ölsböck, “The hole system of triangulated shapes,” Institute of Science
and Technology Austria, 2020.
ista: Ölsböck K. 2020. The hole system of triangulated shapes. Institute of Science
and Technology Austria.
mla: Ölsböck, Katharina. The Hole System of Triangulated Shapes. Institute
of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:7460.
short: K. Ölsböck, The Hole System of Triangulated Shapes, Institute of Science
and Technology Austria, 2020.
date_created: 2020-02-06T14:56:53Z
date_published: 2020-02-10T00:00:00Z
date_updated: 2023-09-07T13:15:30Z
day: '10'
ddc:
- '514'
degree_awarded: PhD
department:
- _id: HeEd
- _id: GradSch
doi: 10.15479/AT:ISTA:7460
file:
- access_level: open_access
checksum: 1df9f8c530b443c0e63a3f2e4fde412e
content_type: application/pdf
creator: koelsboe
date_created: 2020-02-06T14:43:54Z
date_updated: 2020-07-14T12:47:58Z
file_id: '7461'
file_name: thesis_ist-final_noack.pdf
file_size: 76195184
relation: main_file
- access_level: closed
checksum: 7a52383c812b0be64d3826546509e5a4
content_type: application/x-zip-compressed
creator: koelsboe
date_created: 2020-02-06T14:52:45Z
date_updated: 2020-07-14T12:47:58Z
description: latex source files, figures
file_id: '7462'
file_name: latex-files.zip
file_size: 122103715
relation: source_file
file_date_updated: 2020-07-14T12:47:58Z
has_accepted_license: '1'
keyword:
- shape reconstruction
- hole manipulation
- ordered complexes
- Alpha complex
- Wrap complex
- computational topology
- Bregman geometry
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '02'
oa: 1
oa_version: Published Version
page: '155'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '6608'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
title: The hole system of triangulated shapes
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '7464'
abstract:
- lang: eng
text: 'Retrovirus assembly is driven by the multidomain structural protein Gag.
Interactions between the capsid domains (CA) of Gag result in Gag multimerization,
leading to an immature virus particle that is formed by a protein lattice based
on dimeric, trimeric, and hexameric protein contacts. Among retroviruses the inter-
and intra-hexamer contacts differ, especially in the N-terminal sub-domain of
CA (CANTD). For HIV-1 the cellular molecule inositol hexakisphosphate (IP6) interacts
with and stabilizes the immature hexamer, and is required for production of infectious
virus particles. We have used in vitro assembly, cryo-electron tomography and
subtomogram averaging, atomistic molecular dynamics simulations and mutational
analyses to study the HIV-related lentivirus equine infectious anemia virus (EIAV).
In particular, we sought to understand the structural conservation of the immature
lentivirus lattice and the role of IP6 in EIAV assembly. Similar to HIV-1, IP6
strongly promoted in vitro assembly of EIAV Gag proteins into virus-like particles
(VLPs), which took three morphologically highly distinct forms: narrow tubes,
wide tubes, and spheres. Structural characterization of these VLPs to sub-4Å resolution
unexpectedly showed that all three morphologies are based on an immature lattice
with preserved key structural components, highlighting the structural versatility
of CA to form immature assemblies. A direct comparison between EIAV and HIV revealed
that both lentiviruses maintain similar immature interfaces, which are established
by both conserved and non-conserved residues. In both EIAV and HIV-1, IP6 regulates
immature assembly via conserved lysine residues within the CACTD and SP. Lastly,
we demonstrate that IP6 stimulates in vitro assembly of immature particles of
several other retroviruses in the lentivirus genus, suggesting a conserved role
for IP6 in lentiviral assembly.'
acknowledged_ssus:
- _id: ScienComp
article_number: e1008277
article_processing_charge: No
article_type: original
author:
- first_name: Robert A.
full_name: Dick, Robert A.
last_name: Dick
- first_name: Chaoyi
full_name: Xu, Chaoyi
last_name: Xu
- first_name: Dustin R.
full_name: Morado, Dustin R.
last_name: Morado
- first_name: Vladyslav
full_name: Kravchuk, Vladyslav
id: 4D62F2A6-F248-11E8-B48F-1D18A9856A87
last_name: Kravchuk
orcid: 0000-0001-9523-9089
- first_name: Clifton L.
full_name: Ricana, Clifton L.
last_name: Ricana
- first_name: Terri D.
full_name: Lyddon, Terri D.
last_name: Lyddon
- first_name: Arianna M.
full_name: Broad, Arianna M.
last_name: Broad
- first_name: J. Ryan
full_name: Feathers, J. Ryan
last_name: Feathers
- first_name: Marc C.
full_name: Johnson, Marc C.
last_name: Johnson
- first_name: Volker M.
full_name: Vogt, Volker M.
last_name: Vogt
- first_name: Juan R.
full_name: Perilla, Juan R.
last_name: Perilla
- first_name: John A. G.
full_name: Briggs, John A. G.
last_name: Briggs
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Dick RA, Xu C, Morado DR, et al. Structures of immature EIAV Gag lattices reveal
a conserved role for IP6 in lentivirus assembly. PLOS Pathogens. 2020;16(1).
doi:10.1371/journal.ppat.1008277
apa: Dick, R. A., Xu, C., Morado, D. R., Kravchuk, V., Ricana, C. L., Lyddon, T.
D., … Schur, F. K. (2020). Structures of immature EIAV Gag lattices reveal a conserved
role for IP6 in lentivirus assembly. PLOS Pathogens. Public Library of
Science. https://doi.org/10.1371/journal.ppat.1008277
chicago: Dick, Robert A., Chaoyi Xu, Dustin R. Morado, Vladyslav Kravchuk, Clifton
L. Ricana, Terri D. Lyddon, Arianna M. Broad, et al. “Structures of Immature EIAV
Gag Lattices Reveal a Conserved Role for IP6 in Lentivirus Assembly.” PLOS
Pathogens. Public Library of Science, 2020. https://doi.org/10.1371/journal.ppat.1008277.
ieee: R. A. Dick et al., “Structures of immature EIAV Gag lattices reveal
a conserved role for IP6 in lentivirus assembly,” PLOS Pathogens, vol.
16, no. 1. Public Library of Science, 2020.
ista: Dick RA, Xu C, Morado DR, Kravchuk V, Ricana CL, Lyddon TD, Broad AM, Feathers
JR, Johnson MC, Vogt VM, Perilla JR, Briggs JAG, Schur FK. 2020. Structures of
immature EIAV Gag lattices reveal a conserved role for IP6 in lentivirus assembly.
PLOS Pathogens. 16(1), e1008277.
mla: Dick, Robert A., et al. “Structures of Immature EIAV Gag Lattices Reveal a
Conserved Role for IP6 in Lentivirus Assembly.” PLOS Pathogens, vol. 16,
no. 1, e1008277, Public Library of Science, 2020, doi:10.1371/journal.ppat.1008277.
short: R.A. Dick, C. Xu, D.R. Morado, V. Kravchuk, C.L. Ricana, T.D. Lyddon, A.M.
Broad, J.R. Feathers, M.C. Johnson, V.M. Vogt, J.R. Perilla, J.A.G. Briggs, F.K.
Schur, PLOS Pathogens 16 (2020).
date_created: 2020-02-06T18:47:17Z
date_published: 2020-01-27T00:00:00Z
date_updated: 2023-10-17T12:29:34Z
day: '27'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.1371/journal.ppat.1008277
external_id:
isi:
- '000510746400010'
pmid:
- '31986188'
file:
- access_level: open_access
checksum: a297f54d1fef0efe4789ca00f37f241e
content_type: application/pdf
creator: dernst
date_created: 2020-02-11T10:07:28Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7484'
file_name: 2020_PLOSPatho_Dick.pdf
file_size: 4551246
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 16'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26736D6A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31445
name: Structural conservation and diversity in retroviral capsid
publication: PLOS Pathogens
publication_identifier:
issn:
- 1553-7374
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
related_material:
record:
- id: '9723'
relation: research_data
status: deleted
scopus_import: '1'
status: public
title: Structures of immature EIAV Gag lattices reveal a conserved role for IP6 in
lentivirus assembly
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2020'
...
---
_id: '7465'
abstract:
- lang: eng
text: The flexible development of plants is characterized by a high capacity for
post-embryonic organ formation and tissue regeneration, processes, which require
tightly regulated intercellular communication and coordinated tissue (re-)polarization.
The phytohormone auxin, the main driver for these processes, is able to establish
polarized auxin transport channels, which are characterized by the expression
and polar, subcellular localization of the PIN1 auxin transport proteins. These
channels are demarcating the position of future vascular strands necessary for
organ formation and tissue regeneration. Major progress has been made in the last
years to understand how PINs can change their polarity in different contexts and
thus guide auxin flow through the plant. However, it still remains elusive how
auxin mediates the establishment of auxin conducting channels and the formation
of vascular tissue and which cellular processes are involved. By the means of
sophisticated regeneration experiments combined with local auxin applications
in Arabidopsis thaliana inflorescence stems we show that (i) PIN subcellular dynamics,
(ii) PIN internalization by clathrin-mediated trafficking and (iii) an intact
actin cytoskeleton required for post-endocytic trafficking are indispensable for
auxin channel formation, de novo vascular formation and vascular regeneration
after wounding. These observations provide novel insights into cellular mechanism
of coordinated tissue polarization during auxin canalization.
article_number: '110414'
article_processing_charge: No
article_type: original
author:
- first_name: Ewa
full_name: Mazur, Ewa
last_name: Mazur
- first_name: Michelle C
full_name: Gallei, Michelle C
id: 35A03822-F248-11E8-B48F-1D18A9856A87
last_name: Gallei
orcid: 0000-0003-1286-7368
- first_name: Maciek
full_name: Adamowski, Maciek
id: 45F536D2-F248-11E8-B48F-1D18A9856A87
last_name: Adamowski
orcid: 0000-0001-6463-5257
- first_name: Huibin
full_name: Han, Huibin
id: 31435098-F248-11E8-B48F-1D18A9856A87
last_name: Han
- first_name: Hélène S.
full_name: Robert, Hélène S.
last_name: Robert
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Mazur E, Gallei MC, Adamowski M, Han H, Robert HS, Friml J. Clathrin-mediated
trafficking and PIN trafficking are required for auxin canalization and vascular
tissue formation in Arabidopsis. Plant Science. 2020;293(4). doi:10.1016/j.plantsci.2020.110414
apa: Mazur, E., Gallei, M. C., Adamowski, M., Han, H., Robert, H. S., & Friml,
J. (2020). Clathrin-mediated trafficking and PIN trafficking are required for
auxin canalization and vascular tissue formation in Arabidopsis. Plant Science.
Elsevier. https://doi.org/10.1016/j.plantsci.2020.110414
chicago: Mazur, Ewa, Michelle C Gallei, Maciek Adamowski, Huibin Han, Hélène S.
Robert, and Jiří Friml. “Clathrin-Mediated Trafficking and PIN Trafficking Are
Required for Auxin Canalization and Vascular Tissue Formation in Arabidopsis.”
Plant Science. Elsevier, 2020. https://doi.org/10.1016/j.plantsci.2020.110414.
ieee: E. Mazur, M. C. Gallei, M. Adamowski, H. Han, H. S. Robert, and J. Friml,
“Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization
and vascular tissue formation in Arabidopsis,” Plant Science, vol. 293,
no. 4. Elsevier, 2020.
ista: Mazur E, Gallei MC, Adamowski M, Han H, Robert HS, Friml J. 2020. Clathrin-mediated
trafficking and PIN trafficking are required for auxin canalization and vascular
tissue formation in Arabidopsis. Plant Science. 293(4), 110414.
mla: Mazur, Ewa, et al. “Clathrin-Mediated Trafficking and PIN Trafficking Are Required
for Auxin Canalization and Vascular Tissue Formation in Arabidopsis.” Plant
Science, vol. 293, no. 4, 110414, Elsevier, 2020, doi:10.1016/j.plantsci.2020.110414.
short: E. Mazur, M.C. Gallei, M. Adamowski, H. Han, H.S. Robert, J. Friml, Plant
Science 293 (2020).
date_created: 2020-02-09T23:00:50Z
date_published: 2020-04-01T00:00:00Z
date_updated: 2023-08-17T14:37:32Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.plantsci.2020.110414
ec_funded: 1
external_id:
isi:
- '000520609800009'
file:
- access_level: open_access
checksum: f7f27c6a8fea985ceb9279be2204461c
content_type: application/pdf
creator: dernst
date_created: 2020-02-10T08:59:36Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7471'
file_name: 2020_PlantScience_Mazur.pdf
file_size: 3499069
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 293'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
publication: Plant Science
publication_identifier:
eissn:
- '18732259'
issn:
- '01689452'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '11626'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Clathrin-mediated trafficking and PIN trafficking are required for auxin canalization
and vascular tissue formation in Arabidopsis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 293
year: '2020'
...
---
_id: '7466'
abstract:
- lang: eng
text: Unpaired ligands are secreted signals that act via a GP130-like receptor,
domeless, to activate JAK/STAT signalling in Drosophila. Like many mammalian cytokines,
unpaireds can be activated by infection and other stresses and can promote insulin
resistance in target tissues. However, the importance of this effect in non-inflammatory
physiology is unknown. Here, we identify a requirement for unpaired-JAK signalling
as a metabolic regulator in healthy adult Drosophila muscle. Adult muscles show
basal JAK-STAT signalling activity in the absence of any immune challenge. Plasmatocytes
(Drosophila macrophages) are an important source of this tonic signal. Loss of
the dome receptor on adult muscles significantly reduces lifespan and causes local
and systemic metabolic pathology. These pathologies result from hyperactivation
of AKT and consequent deregulation of metabolism. Thus, we identify a cytokine
signal that must be received in muscle to control AKT activity and metabolic homeostasis.
article_number: e51595
article_processing_charge: No
article_type: original
author:
- first_name: Katrin
full_name: Kierdorf, Katrin
last_name: Kierdorf
- first_name: Fabian
full_name: Hersperger, Fabian
last_name: Hersperger
- first_name: Jessica
full_name: Sharrock, Jessica
last_name: Sharrock
- first_name: Crystal M.
full_name: Vincent, Crystal M.
last_name: Vincent
- first_name: Pinar
full_name: Ustaoglu, Pinar
last_name: Ustaoglu
- first_name: Jiawen
full_name: Dou, Jiawen
last_name: Dou
- first_name: Attila
full_name: György, Attila
id: 3BCEDBE0-F248-11E8-B48F-1D18A9856A87
last_name: György
orcid: 0000-0002-1819-198X
- first_name: Olaf
full_name: Groß, Olaf
last_name: Groß
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Marc S.
full_name: Dionne, Marc S.
last_name: Dionne
citation:
ama: Kierdorf K, Hersperger F, Sharrock J, et al. Muscle function and homeostasis
require cytokine inhibition of AKT activity in Drosophila. eLife. 2020;9.
doi:10.7554/eLife.51595
apa: Kierdorf, K., Hersperger, F., Sharrock, J., Vincent, C. M., Ustaoglu, P., Dou,
J., … Dionne, M. S. (2020). Muscle function and homeostasis require cytokine inhibition
of AKT activity in Drosophila. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.51595
chicago: Kierdorf, Katrin, Fabian Hersperger, Jessica Sharrock, Crystal M. Vincent,
Pinar Ustaoglu, Jiawen Dou, Attila György, Olaf Groß, Daria E Siekhaus, and Marc
S. Dionne. “Muscle Function and Homeostasis Require Cytokine Inhibition of AKT
Activity in Drosophila.” ELife. eLife Sciences Publications, 2020. https://doi.org/10.7554/eLife.51595.
ieee: K. Kierdorf et al., “Muscle function and homeostasis require cytokine
inhibition of AKT activity in Drosophila,” eLife, vol. 9. eLife Sciences
Publications, 2020.
ista: Kierdorf K, Hersperger F, Sharrock J, Vincent CM, Ustaoglu P, Dou J, György
A, Groß O, Siekhaus DE, Dionne MS. 2020. Muscle function and homeostasis require
cytokine inhibition of AKT activity in Drosophila. eLife. 9, e51595.
mla: Kierdorf, Katrin, et al. “Muscle Function and Homeostasis Require Cytokine
Inhibition of AKT Activity in Drosophila.” ELife, vol. 9, e51595, eLife
Sciences Publications, 2020, doi:10.7554/eLife.51595.
short: K. Kierdorf, F. Hersperger, J. Sharrock, C.M. Vincent, P. Ustaoglu, J. Dou,
A. György, O. Groß, D.E. Siekhaus, M.S. Dionne, ELife 9 (2020).
date_created: 2020-02-09T23:00:51Z
date_published: 2020-01-20T00:00:00Z
date_updated: 2023-08-17T14:36:39Z
day: '20'
ddc:
- '570'
department:
- _id: DaSi
doi: 10.7554/eLife.51595
external_id:
isi:
- '000512304800001'
file:
- access_level: open_access
checksum: 3a072be843f416c7a7d532a51dc0addb
content_type: application/pdf
creator: dernst
date_created: 2020-02-10T08:53:16Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7470'
file_name: 2020_eLife_Kierdorf.pdf
file_size: 4959933
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 253B6E48-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P29638
name: Drosophila TNFa´s Funktion in Immunzellen
publication: eLife
publication_identifier:
eissn:
- 2050084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Muscle function and homeostasis require cytokine inhibition of AKT activity
in Drosophila
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2020'
...
---
_id: '7467'
abstract:
- lang: eng
text: Nanomaterials produced from the bottom-up assembly of nanocrystals may incorporate
∼1020–1021 cm–3 not fully coordinated surface atoms, i.e., ∼1020–1021 cm–3 potential
donor or acceptor states that can strongly affect transport properties. Therefore,
to exploit the full potential of nanocrystal building blocks to produce functional
nanomaterials and thin films, a proper control of their surface chemistry is required.
Here, we analyze how the ligand stripping procedure influences the charge and
heat transport properties of sintered PbSe nanomaterials produced from the bottom-up
assembly of colloidal PbSe nanocrystals. First, we show that the removal of the
native organic ligands by thermal decomposition in an inert atmosphere leaves
relatively large amounts of carbon at the crystal interfaces. This carbon blocks
crystal growth during consolidation and at the same time hampers charge and heat
transport through the final nanomaterial. Second, we demonstrate that, by stripping
ligands from the nanocrystal surface before consolidation, nanomaterials with
larger crystal domains, lower porosity, and higher charge carrier concentrations
are obtained, thus resulting in nanomaterials with higher electrical and thermal
conductivities. In addition, the ligand displacement leaves the nanocrystal surface
unprotected, facilitating oxidation and chalcogen evaporation. The influence of
the ligand displacement on the nanomaterial charge transport properties is rationalized
here using a two-band model based on the standard Boltzmann transport equation
with the relaxation time approximation. Finally, we present an application of
the produced functional nanomaterials by modeling, fabricating, and testing a
simple PbSe-based thermoelectric device with a ring geometry.
acknowledgement: This work was supported by the Spanish Ministerio de Economía y Competitividad
through the project SEHTOP (ENE2016-77798-C4-3-R) and the Generalitat de Catalunya
through the project 2017SGR1246. D.C. acknowledges support from Universidad Nacional
de Colombia. Y.L. acknowledges funding from the European Union’s Horizon 2020 research
and innovation programme under the Marie Sklodowska-Curie grant agreement no. 754411.
M.I. acknowledges financial support from IST Austria.
article_processing_charge: No
article_type: original
author:
- first_name: Doris
full_name: Cadavid, Doris
last_name: Cadavid
- first_name: Silvia
full_name: Ortega, Silvia
last_name: Ortega
- first_name: Sergio
full_name: Illera, Sergio
last_name: Illera
- first_name: Yu
full_name: Liu, Yu
id: 2A70014E-F248-11E8-B48F-1D18A9856A87
last_name: Liu
orcid: 0000-0001-7313-6740
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Alexey
full_name: Shavel, Alexey
last_name: Shavel
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Antonio M.
full_name: López, Antonio M.
last_name: López
- first_name: Germán
full_name: Noriega, Germán
last_name: Noriega
- first_name: Oscar Juan
full_name: Durá, Oscar Juan
last_name: Durá
- first_name: M. A.
full_name: López De La Torre, M. A.
last_name: López De La Torre
- first_name: Joan Daniel
full_name: Prades, Joan Daniel
last_name: Prades
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
citation:
ama: Cadavid D, Ortega S, Illera S, et al. Influence of the ligand stripping on
the transport properties of nanoparticle-based PbSe nanomaterials. ACS Applied
Energy Materials. 2020;3(3):2120-2129. doi:10.1021/acsaem.9b02137
apa: Cadavid, D., Ortega, S., Illera, S., Liu, Y., Ibáñez, M., Shavel, A., … Cabot,
A. (2020). Influence of the ligand stripping on the transport properties of nanoparticle-based
PbSe nanomaterials. ACS Applied Energy Materials. American Chemical Society.
https://doi.org/10.1021/acsaem.9b02137
chicago: Cadavid, Doris, Silvia Ortega, Sergio Illera, Yu Liu, Maria Ibáñez, Alexey
Shavel, Yu Zhang, et al. “Influence of the Ligand Stripping on the Transport Properties
of Nanoparticle-Based PbSe Nanomaterials.” ACS Applied Energy Materials.
American Chemical Society, 2020. https://doi.org/10.1021/acsaem.9b02137.
ieee: D. Cadavid et al., “Influence of the ligand stripping on the transport
properties of nanoparticle-based PbSe nanomaterials,” ACS Applied Energy Materials,
vol. 3, no. 3. American Chemical Society, pp. 2120–2129, 2020.
ista: Cadavid D, Ortega S, Illera S, Liu Y, Ibáñez M, Shavel A, Zhang Y, Li M, López
AM, Noriega G, Durá OJ, López De La Torre MA, Prades JD, Cabot A. 2020. Influence
of the ligand stripping on the transport properties of nanoparticle-based PbSe
nanomaterials. ACS Applied Energy Materials. 3(3), 2120–2129.
mla: Cadavid, Doris, et al. “Influence of the Ligand Stripping on the Transport
Properties of Nanoparticle-Based PbSe Nanomaterials.” ACS Applied Energy Materials,
vol. 3, no. 3, American Chemical Society, 2020, pp. 2120–29, doi:10.1021/acsaem.9b02137.
short: D. Cadavid, S. Ortega, S. Illera, Y. Liu, M. Ibáñez, A. Shavel, Y. Zhang,
M. Li, A.M. López, G. Noriega, O.J. Durá, M.A. López De La Torre, J.D. Prades,
A. Cabot, ACS Applied Energy Materials 3 (2020) 2120–2129.
date_created: 2020-02-09T23:00:52Z
date_published: 2020-03-01T00:00:00Z
date_updated: 2023-08-17T14:36:16Z
day: '01'
ddc:
- '540'
department:
- _id: MaIb
doi: 10.1021/acsaem.9b02137
ec_funded: 1
external_id:
isi:
- '000526598300012'
file:
- access_level: open_access
checksum: f23be731a766a480c77c962c1380315c
content_type: application/pdf
creator: dernst
date_created: 2022-08-23T08:34:17Z
date_updated: 2022-08-23T08:34:17Z
file_id: '11942'
file_name: 2020_ACSAppliedEnergyMat_Cadavid.pdf
file_size: 6423548
relation: main_file
success: 1
file_date_updated: 2022-08-23T08:34:17Z
has_accepted_license: '1'
intvolume: ' 3'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 2120-2129
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: ACS Applied Energy Materials
publication_identifier:
eissn:
- 2574-0962
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Influence of the ligand stripping on the transport properties of nanoparticle-based
PbSe nanomaterials
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 3
year: '2020'
...
---
_id: '7472'
abstract:
- lang: eng
text: Temporally organized reactivation of experiences during awake immobility periods
is thought to underlie cognitive processes like planning and evaluation. While
replay of trajectories is well established for the hippocampus, it is unclear
whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral
experiences in the awake state to support task execution. We simultaneously recorded
from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent
rule-switching task on a plus maze. We found that mPFC neuronal activity encoded
relative positions between the start and goal. During awake immobility periods,
the mPFC replayed temporally organized sequences of these generalized positions,
resembling entire spatial trajectories. The occurrence of mPFC trajectory replay
positively correlated with rule-switching performance. However, hippocampal and
mPFC trajectory replay occurred independently, indicating different functions.
These results demonstrate that the mPFC can replay ordered activity patterns representing
generalized locations and suggest that mPFC replay might have a role in flexible
behavior.
acknowledged_ssus:
- _id: M-Shop
acknowledgement: We thank Todor Asenov and Thomas Menner from the Machine Shop for
the drive design and production, Hugo Malagon-Vina for assistance in maze automatization,
Jago Wallenschus for taking the images of the histology, and Federico Stella and
Juan Felipe Ramirez-Villegas for comments on an earlier version of the manuscript.
This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616 ).
article_processing_charge: No
article_type: original
author:
- first_name: Karola
full_name: Käfer, Karola
id: 2DAA49AA-F248-11E8-B48F-1D18A9856A87
last_name: Käfer
- first_name: Michele
full_name: Nardin, Michele
id: 30BD0376-F248-11E8-B48F-1D18A9856A87
last_name: Nardin
orcid: 0000-0001-8849-6570
- first_name: Karel
full_name: Blahna, Karel
id: 3EA859AE-F248-11E8-B48F-1D18A9856A87
last_name: Blahna
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
citation:
ama: Käfer K, Nardin M, Blahna K, Csicsvari JL. Replay of behavioral sequences in
the medial prefrontal cortex during rule switching. Neuron. 2020;106(1):P154-165.e6.
doi:10.1016/j.neuron.2020.01.015
apa: Käfer, K., Nardin, M., Blahna, K., & Csicsvari, J. L. (2020). Replay of
behavioral sequences in the medial prefrontal cortex during rule switching. Neuron.
Elsevier. https://doi.org/10.1016/j.neuron.2020.01.015
chicago: Käfer, Karola, Michele Nardin, Karel Blahna, and Jozsef L Csicsvari. “Replay
of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.”
Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.015.
ieee: K. Käfer, M. Nardin, K. Blahna, and J. L. Csicsvari, “Replay of behavioral
sequences in the medial prefrontal cortex during rule switching,” Neuron,
vol. 106, no. 1. Elsevier, p. P154–165.e6, 2020.
ista: Käfer K, Nardin M, Blahna K, Csicsvari JL. 2020. Replay of behavioral sequences
in the medial prefrontal cortex during rule switching. Neuron. 106(1), P154–165.e6.
mla: Käfer, Karola, et al. “Replay of Behavioral Sequences in the Medial Prefrontal
Cortex during Rule Switching.” Neuron, vol. 106, no. 1, Elsevier, 2020,
p. P154–165.e6, doi:10.1016/j.neuron.2020.01.015.
short: K. Käfer, M. Nardin, K. Blahna, J.L. Csicsvari, Neuron 106 (2020) P154–165.e6.
date_created: 2020-02-10T15:45:48Z
date_published: 2020-04-08T00:00:00Z
date_updated: 2023-08-17T14:38:02Z
day: '08'
department:
- _id: JoCs
doi: 10.1016/j.neuron.2020.01.015
ec_funded: 1
external_id:
isi:
- '000525319300016'
pmid:
- '32032512'
intvolume: ' 106'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.neuron.2020.01.015
month: '04'
oa: 1
oa_version: Published Version
page: P154-165.e6
pmid: 1
project:
- _id: 257BBB4C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '607616'
name: Inter-and intracellular signalling in schizophrenia
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/this-brain-area-helps-us-decide/
scopus_import: '1'
status: public
title: Replay of behavioral sequences in the medial prefrontal cortex during rule
switching
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 106
year: '2020'
...
---
_id: '7473'
abstract:
- lang: eng
text: How structural and functional properties of synapses relate to each other
is a fundamental question in neuroscience. Electrophysiology has elucidated mechanisms
of synaptic transmission, and electron microscopy (EM) has provided insight into
morphological properties of synapses. Here we describe an enhanced method for
functional EM (“flash and freeze”), combining optogenetic stimulation with high-pressure
freezing. We demonstrate that the improved method can be applied to intact networks
in acute brain slices and organotypic slice cultures from mice. As a proof of
concept, we probed vesicle pool changes during synaptic transmission at the hippocampal
mossy fiber-CA3 pyramidal neuron synapse. Our findings show overlap of the docked
vesicle pool and the functionally defined readily releasable pool and provide
evidence of fast endocytosis at this synapse. Functional EM with acute slices
and slice cultures has the potential to reveal the structural and functional mechanisms
of transmission in intact, genetically perturbed, and disease-affected synapses.
acknowledgement: This project has received funding from the European Research Council
(ERC) and European Commission (EC), under the European Union’s Horizon 2020 research
and innovation programme (ERC grant agreement No. 692692 and Marie Sklodowska-Curie
708497) and from Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27
Wittgenstein award and DK W1205-B09). We thank Johann Danzl and Ryuichi Shigemoto
for critically reading the manuscript; Walter Kaufmann, Daniel Gutl, and Vanessa
Zheden for extensive EM training, advice, and experimental assistance; Benjamin
Suter for substantial help with light stimulation, ImageJ plugins for analysis,
and manuscript editing; Florian Marr and Christina Altmutter for technical support;
Eleftheria Kralli-Beller for manuscript editing; Julia König and Paul Wurzinger
(Leica Microsystems) for helpful technical discussions; and Taija Makinen for providing
the Prox1-CreERT2 mouse line.
article_processing_charge: No
article_type: original
author:
- first_name: Carolina
full_name: Borges Merjane, Carolina
id: 4305C450-F248-11E8-B48F-1D18A9856A87
last_name: Borges Merjane
orcid: 0000-0003-0005-401X
- first_name: Olena
full_name: Kim, Olena
id: 3F8ABDDA-F248-11E8-B48F-1D18A9856A87
last_name: Kim
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Borges Merjane C, Kim O, Jonas PM. Functional electron microscopy (“Flash and
Freeze”) of identified cortical synapses in acute brain slices. Neuron.
2020;105:992-1006. doi:10.1016/j.neuron.2019.12.022
apa: Borges Merjane, C., Kim, O., & Jonas, P. M. (2020). Functional electron
microscopy (“Flash and Freeze”) of identified cortical synapses in acute brain
slices. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2019.12.022
chicago: Borges Merjane, Carolina, Olena Kim, and Peter M Jonas. “Functional Electron
Microscopy (‘Flash and Freeze’) of Identified Cortical Synapses in Acute Brain
Slices.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2019.12.022.
ieee: C. Borges Merjane, O. Kim, and P. M. Jonas, “Functional electron microscopy
(‘Flash and Freeze’) of identified cortical synapses in acute brain slices,” Neuron,
vol. 105. Elsevier, pp. 992–1006, 2020.
ista: Borges Merjane C, Kim O, Jonas PM. 2020. Functional electron microscopy (“Flash
and Freeze”) of identified cortical synapses in acute brain slices. Neuron. 105,
992–1006.
mla: Borges Merjane, Carolina, et al. “Functional Electron Microscopy (‘Flash and
Freeze’) of Identified Cortical Synapses in Acute Brain Slices.” Neuron,
vol. 105, Elsevier, 2020, pp. 992–1006, doi:10.1016/j.neuron.2019.12.022.
short: C. Borges Merjane, O. Kim, P.M. Jonas, Neuron 105 (2020) 992–1006.
date_created: 2020-02-10T15:59:45Z
date_published: 2020-03-18T00:00:00Z
date_updated: 2024-03-25T23:30:04Z
day: '18'
ddc:
- '570'
department:
- _id: PeJo
doi: 10.1016/j.neuron.2019.12.022
ec_funded: 1
external_id:
isi:
- '000520854700008'
pmid:
- '31928842'
file:
- access_level: open_access
checksum: 3582664addf26859e86ac5bec3e01416
content_type: application/pdf
creator: dernst
date_created: 2020-11-20T08:58:53Z
date_updated: 2020-11-20T08:58:53Z
file_id: '8778'
file_name: 2020_Neuron_BorgesMerjane.pdf
file_size: 9712957
relation: main_file
success: 1
file_date_updated: 2020-11-20T08:58:53Z
has_accepted_license: '1'
intvolume: ' 105'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 992-1006
pmid: 1
project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 25BAF7B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '708497'
name: Presynaptic calcium channels distribution and impact on coupling at the hippocampal
mossy fiber synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
- _id: 25C3DBB6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W01205
name: Zellkommunikation in Gesundheit und Krankheit
publication: Neuron
publication_identifier:
issn:
- 0896-6273
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/flash-and-freeze-reveals-dynamics-of-nerve-connections/
record:
- id: '11196'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Functional electron microscopy (“Flash and Freeze”) of identified cortical
synapses in acute brain slices
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 105
year: '2020'
...
---
_id: '7474'
abstract:
- lang: eng
text: This booklet is a collection of abstracts presented at the AHPC conference.
article_processing_charge: No
citation:
ama: 'Schlögl A, Kiss J, Elefante S, eds. Austrian High-Performance-Computing
Meeting (AHPC2020). Klosterneuburg, Austria: IST Austria; 2020. doi:10.15479/AT:ISTA:7474'
apa: 'Schlögl, A., Kiss, J., & Elefante, S. (Eds.). (2020). Austrian High-Performance-Computing
meeting (AHPC2020). Presented at the AHPC: Austrian High-Performance-Computing
Meeting, Klosterneuburg, Austria: IST Austria. https://doi.org/10.15479/AT:ISTA:7474'
chicago: 'Schlögl, Alois, Janos Kiss, and Stefano Elefante, eds. Austrian High-Performance-Computing
Meeting (AHPC2020). Klosterneuburg, Austria: IST Austria, 2020. https://doi.org/10.15479/AT:ISTA:7474.'
ieee: 'A. Schlögl, J. Kiss, and S. Elefante, Eds., Austrian High-Performance-Computing
meeting (AHPC2020). Klosterneuburg, Austria: IST Austria, 2020.'
ista: 'Schlögl A, Kiss J, Elefante S eds. 2020. Austrian High-Performance-Computing
meeting (AHPC2020), Klosterneuburg, Austria: IST Austria, 72p.'
mla: Schlögl, Alois, et al., editors. Austrian High-Performance-Computing Meeting
(AHPC2020). IST Austria, 2020, doi:10.15479/AT:ISTA:7474.
short: A. Schlögl, J. Kiss, S. Elefante, eds., Austrian High-Performance-Computing
Meeting (AHPC2020), IST Austria, Klosterneuburg, Austria, 2020.
conference:
end_date: 2020-02-21
location: Klosterneuburg, Austria
name: 'AHPC: Austrian High-Performance-Computing Meeting'
start_date: 2020-02-19
date_created: 2020-02-11T07:59:04Z
date_published: 2020-02-19T00:00:00Z
date_updated: 2023-05-16T07:48:28Z
day: '19'
ddc:
- '000'
department:
- _id: ScienComp
doi: 10.15479/AT:ISTA:7474
editor:
- first_name: Alois
full_name: Schlögl, Alois
id: 45BF87EE-F248-11E8-B48F-1D18A9856A87
last_name: Schlögl
orcid: 0000-0002-5621-8100
- first_name: Janos
full_name: Kiss, Janos
id: 3D3A06F8-F248-11E8-B48F-1D18A9856A87
last_name: Kiss
- first_name: Stefano
full_name: Elefante, Stefano
id: 490F40CE-F248-11E8-B48F-1D18A9856A87
last_name: Elefante
file:
- access_level: open_access
checksum: 49798edb9e57bbd6be18362d1d7b18a9
content_type: application/pdf
creator: schloegl
date_created: 2020-02-19T06:53:38Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7504'
file_name: BOOKLET_AHPC2020.final.pdf
file_size: 90899507
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '72'
place: Klosterneuburg, Austria
publication_identifier:
isbn:
- 978-3-99078-004-6
publication_status: published
publisher: IST Austria
quality_controlled: '1'
status: public
title: Austrian High-Performance-Computing meeting (AHPC2020)
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: book_editor
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7477'
abstract:
- lang: eng
text: We present conductance-matrix measurements of a three-terminal superconductor-semiconductor
hybrid device consisting of two normal leads and one superconducting lead. Using
a symmetry decomposition of the conductance, we find that antisymmetric components
of pairs of local and nonlocal conductances qualitatively match at energies below
the superconducting gap, and we compare this finding with symmetry relations based
on a noninteracting scattering matrix approach. Further, the local charge character
of Andreev bound states is extracted from the symmetry-decomposed conductance
data and is found to be similar at both ends of the device and tunable with gate
voltage. Finally, we measure the conductance matrix as a function of magnetic
field and identify correlated splittings in low-energy features, demonstrating
how conductance-matrix measurements can complement traditional single-probe measurements
in the search for Majorana zero modes.
article_number: '036802'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: G. C.
full_name: Ménard, G. C.
last_name: Ménard
- first_name: G. L. R.
full_name: Anselmetti, G. L. R.
last_name: Anselmetti
- first_name: E. A.
full_name: Martinez, E. A.
last_name: Martinez
- first_name: D.
full_name: Puglia, D.
last_name: Puglia
- first_name: F. K.
full_name: Malinowski, F. K.
last_name: Malinowski
- first_name: J. S.
full_name: Lee, J. S.
last_name: Lee
- first_name: S.
full_name: Choi, S.
last_name: Choi
- first_name: M.
full_name: Pendharkar, M.
last_name: Pendharkar
- first_name: C. J.
full_name: Palmstrøm, C. J.
last_name: Palmstrøm
- first_name: K.
full_name: Flensberg, K.
last_name: Flensberg
- first_name: C. M.
full_name: Marcus, C. M.
last_name: Marcus
- first_name: L.
full_name: Casparis, L.
last_name: Casparis
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
citation:
ama: Ménard GC, Anselmetti GLR, Martinez EA, et al. Conductance-matrix symmetries
of a three-terminal hybrid device. Physical Review Letters. 2020;124(3).
doi:10.1103/physrevlett.124.036802
apa: Ménard, G. C., Anselmetti, G. L. R., Martinez, E. A., Puglia, D., Malinowski,
F. K., Lee, J. S., … Higginbotham, A. P. (2020). Conductance-matrix symmetries
of a three-terminal hybrid device. Physical Review Letters. APS. https://doi.org/10.1103/physrevlett.124.036802
chicago: Ménard, G. C., G. L. R. Anselmetti, E. A. Martinez, D. Puglia, F. K. Malinowski,
J. S. Lee, S. Choi, et al. “Conductance-Matrix Symmetries of a Three-Terminal
Hybrid Device.” Physical Review Letters. APS, 2020. https://doi.org/10.1103/physrevlett.124.036802.
ieee: G. C. Ménard et al., “Conductance-matrix symmetries of a three-terminal
hybrid device,” Physical Review Letters, vol. 124, no. 3. APS, 2020.
ista: Ménard GC, Anselmetti GLR, Martinez EA, Puglia D, Malinowski FK, Lee JS, Choi
S, Pendharkar M, Palmstrøm CJ, Flensberg K, Marcus CM, Casparis L, Higginbotham
AP. 2020. Conductance-matrix symmetries of a three-terminal hybrid device. Physical
Review Letters. 124(3), 036802.
mla: Ménard, G. C., et al. “Conductance-Matrix Symmetries of a Three-Terminal Hybrid
Device.” Physical Review Letters, vol. 124, no. 3, 036802, APS, 2020, doi:10.1103/physrevlett.124.036802.
short: G.C. Ménard, G.L.R. Anselmetti, E.A. Martinez, D. Puglia, F.K. Malinowski,
J.S. Lee, S. Choi, M. Pendharkar, C.J. Palmstrøm, K. Flensberg, C.M. Marcus, L.
Casparis, A.P. Higginbotham, Physical Review Letters 124 (2020).
date_created: 2020-02-11T08:50:02Z
date_published: 2020-01-24T00:00:00Z
date_updated: 2021-01-12T08:13:48Z
day: '24'
doi: 10.1103/physrevlett.124.036802
extern: '1'
external_id:
arxiv:
- '1905.05505'
intvolume: ' 124'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.05505
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review Letters
publication_identifier:
issn:
- 0031-9007
- 1079-7114
publication_status: published
publisher: APS
quality_controlled: '1'
status: public
title: Conductance-matrix symmetries of a three-terminal hybrid device
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 124
year: '2020'
...
---
_id: '7478'
abstract:
- lang: eng
text: Two-terminal conductance spectroscopy of superconducting devices is a common
tool for probing Andreev and Majorana bound states. Here, we study theoretically
a three-terminal setup, with two normal leads coupled to a grounded superconducting
terminal. Using a single-electron scattering matrix, we derive the subgap conductance
matrix for the normal leads and discuss its symmetries. In particular, we show
that the local and the nonlocal elements of the conductance matrix have pairwise
identical antisymmetric components. Moreover, we find that the nonlocal elements
are directly related to the local BCS charges of the bound states close to the
normal probes and we show how the BCS charge of overlapping Majorana bound states
can be extracted from experiments.
article_number: '036801'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Jeroen
full_name: Danon, Jeroen
last_name: Danon
- first_name: Anna Birk
full_name: Hellenes, Anna Birk
last_name: Hellenes
- first_name: Esben Bork
full_name: Hansen, Esben Bork
last_name: Hansen
- first_name: Lucas
full_name: Casparis, Lucas
last_name: Casparis
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
- first_name: Karsten
full_name: Flensberg, Karsten
last_name: Flensberg
citation:
ama: 'Danon J, Hellenes AB, Hansen EB, Casparis L, Higginbotham AP, Flensberg K.
Nonlocal conductance spectroscopy of Andreev bound states: Symmetry relations
and BCS charges. Physical Review Letters. 2020;124(3). doi:10.1103/physrevlett.124.036801'
apa: 'Danon, J., Hellenes, A. B., Hansen, E. B., Casparis, L., Higginbotham, A.
P., & Flensberg, K. (2020). Nonlocal conductance spectroscopy of Andreev bound
states: Symmetry relations and BCS charges. Physical Review Letters. APS.
https://doi.org/10.1103/physrevlett.124.036801'
chicago: 'Danon, Jeroen, Anna Birk Hellenes, Esben Bork Hansen, Lucas Casparis,
Andrew P Higginbotham, and Karsten Flensberg. “Nonlocal Conductance Spectroscopy
of Andreev Bound States: Symmetry Relations and BCS Charges.” Physical Review
Letters. APS, 2020. https://doi.org/10.1103/physrevlett.124.036801.'
ieee: 'J. Danon, A. B. Hellenes, E. B. Hansen, L. Casparis, A. P. Higginbotham,
and K. Flensberg, “Nonlocal conductance spectroscopy of Andreev bound states:
Symmetry relations and BCS charges,” Physical Review Letters, vol. 124,
no. 3. APS, 2020.'
ista: 'Danon J, Hellenes AB, Hansen EB, Casparis L, Higginbotham AP, Flensberg K.
2020. Nonlocal conductance spectroscopy of Andreev bound states: Symmetry relations
and BCS charges. Physical Review Letters. 124(3), 036801.'
mla: 'Danon, Jeroen, et al. “Nonlocal Conductance Spectroscopy of Andreev Bound
States: Symmetry Relations and BCS Charges.” Physical Review Letters, vol.
124, no. 3, 036801, APS, 2020, doi:10.1103/physrevlett.124.036801.'
short: J. Danon, A.B. Hellenes, E.B. Hansen, L. Casparis, A.P. Higginbotham, K.
Flensberg, Physical Review Letters 124 (2020).
date_created: 2020-02-11T08:55:40Z
date_published: 2020-01-24T00:00:00Z
date_updated: 2021-01-12T08:13:48Z
day: '24'
doi: 10.1103/physrevlett.124.036801
extern: '1'
external_id:
arxiv:
- '1905.05438'
intvolume: ' 124'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1905.05438
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review Letters
publication_identifier:
issn:
- 0031-9007
- 1079-7114
publication_status: published
publisher: APS
quality_controlled: '1'
status: public
title: 'Nonlocal conductance spectroscopy of Andreev bound states: Symmetry relations
and BCS charges'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 124
year: '2020'
...
---
_id: '7481'
abstract:
- lang: eng
text: 'We address the following question: How redundant is the parameterisation
of ReLU networks? Specifically, we consider transformations of the weight space
which leave the function implemented by the network intact. Two such transformations
are known for feed-forward architectures: permutation of neurons within a layer,
and positive scaling of all incoming weights of a neuron coupled with inverse
scaling of its outgoing weights. In this work, we show for architectures with
non-increasing widths that permutation and scaling are in fact the only function-preserving
weight transformations. For any eligible architecture we give an explicit construction
of a neural network such that any other network that implements the same function
can be obtained from the original one by the application of permutations and rescaling. The
proof relies on a geometric understanding of boundaries between linear regions
of ReLU networks, and we hope the developed mathematical tools are of independent
interest.'
article_processing_charge: No
author:
- first_name: Phuong
full_name: Bui Thi Mai, Phuong
id: 3EC6EE64-F248-11E8-B48F-1D18A9856A87
last_name: Bui Thi Mai
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Phuong M, Lampert C. Functional vs. parametric equivalence of ReLU networks.
In: 8th International Conference on Learning Representations. ; 2020.'
apa: Phuong, M., & Lampert, C. (2020). Functional vs. parametric equivalence
of ReLU networks. In 8th International Conference on Learning Representations.
Online.
chicago: Phuong, Mary, and Christoph Lampert. “Functional vs. Parametric Equivalence
of ReLU Networks.” In 8th International Conference on Learning Representations,
2020.
ieee: M. Phuong and C. Lampert, “Functional vs. parametric equivalence of ReLU networks,”
in 8th International Conference on Learning Representations, Online, 2020.
ista: 'Phuong M, Lampert C. 2020. Functional vs. parametric equivalence of ReLU
networks. 8th International Conference on Learning Representations. ICLR: International
Conference on Learning Representations.'
mla: Phuong, Mary, and Christoph Lampert. “Functional vs. Parametric Equivalence
of ReLU Networks.” 8th International Conference on Learning Representations,
2020.
short: M. Phuong, C. Lampert, in:, 8th International Conference on Learning Representations,
2020.
conference:
end_date: 2020-04-30
location: Online
name: 'ICLR: International Conference on Learning Representations'
start_date: 2020-04-27
date_created: 2020-02-11T09:07:37Z
date_published: 2020-04-26T00:00:00Z
date_updated: 2023-09-07T13:29:50Z
day: '26'
ddc:
- '000'
department:
- _id: ChLa
file:
- access_level: open_access
checksum: 8d372ea5defd8cb8fdc430111ed754a9
content_type: application/pdf
creator: bphuong
date_created: 2020-02-11T09:07:27Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7482'
file_name: main.pdf
file_size: 405469
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: 8th International Conference on Learning Representations
publication_status: published
quality_controlled: '1'
related_material:
link:
- relation: supplementary_material
url: https://iclr.cc/virtual_2020/poster_Bylx-TNKvH.html
record:
- id: '9418'
relation: dissertation_contains
status: public
status: public
title: Functional vs. parametric equivalence of ReLU networks
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7487'
abstract:
- lang: eng
text: 'Glutaminase (GA) catalyzes the first step in mitochondrial glutaminolysis
playing a key role in cancer metabolic reprogramming. Humans express two types
of GA isoforms: GLS and GLS2. GLS isozymes have been consistently related to cell
proliferation, but the role of GLS2 in cancer remains poorly understood. GLS2
is repressed in many tumor cells and a better understanding of its function in
tumorigenesis may further the development of new therapeutic approaches. We analyzed
GLS2 expression in HCC, GBM and neuroblastoma cells, as well as in monkey COS-7
cells. We studied GLS2 expression after induction of differentiation with phorbol
ester (PMA) and transduction with the full-length cDNA of GLS2. In parallel, we
investigated cell cycle progression and levels of p53, p21 and c-Myc proteins.
Using the baculovirus system, human GLS2 protein was overexpressed, purified and
analyzed for posttranslational modifications employing a proteomics LC-MS/MS platform.
We have demonstrated a dual targeting of GLS2 in human cancer cells. Immunocytochemistry
and subcellular fractionation gave consistent results demonstrating nuclear and
mitochondrial locations, with the latter being predominant. Nuclear targeting
was confirmed in cancer cells overexpressing c-Myc- and GFP-tagged GLS2 proteins.
We assessed the subnuclear location finding a widespread distribution of GLS2
in the nucleoplasm without clear overlapping with specific nuclear substructures.
GLS2 expression and nuclear accrual notably increased by treatment of SH-SY5Y
cells with PMA and it correlated with cell cycle arrest at G2/M, upregulation
of tumor suppressor p53 and p21 protein. A similar response was obtained by overexpression
of GLS2 in T98G glioma cells, including downregulation of oncogene c-Myc. Furthermore,
human GLS2 was identified as being hypusinated by MS analysis, a posttranslational
modification which may be relevant for its nuclear targeting and/or function.
Our studies provide evidence for a tumor suppressor role of GLS2 in certain types
of cancer. The data imply that GLS2 can be regarded as a highly mobile and multilocalizing
protein translocated to both mitochondria and nuclei. Upregulation of GLS2 in
cancer cells induced an antiproliferative response with cell cycle arrest at the
G2/M phase.'
article_number: '2259'
article_processing_charge: No
article_type: original
author:
- first_name: Amada R.
full_name: López De La Oliva, Amada R.
last_name: López De La Oliva
- first_name: José A.
full_name: Campos-Sandoval, José A.
last_name: Campos-Sandoval
- first_name: María C.
full_name: Gómez-García, María C.
last_name: Gómez-García
- first_name: Carolina
full_name: Cardona, Carolina
last_name: Cardona
- first_name: Mercedes
full_name: Martín-Rufián, Mercedes
last_name: Martín-Rufián
- first_name: Fernando J.
full_name: Sialana, Fernando J.
last_name: Sialana
- first_name: Laura
full_name: Castilla, Laura
last_name: Castilla
- first_name: Narkhyun
full_name: Bae, Narkhyun
id: 3A5F7CD8-F248-11E8-B48F-1D18A9856A87
last_name: Bae
- first_name: Carolina
full_name: Lobo, Carolina
last_name: Lobo
- first_name: Ana
full_name: Peñalver, Ana
last_name: Peñalver
- first_name: Marina
full_name: García-Frutos, Marina
last_name: García-Frutos
- first_name: David
full_name: Carro, David
last_name: Carro
- first_name: Victoria
full_name: Enrique, Victoria
last_name: Enrique
- first_name: José C.
full_name: Paz, José C.
last_name: Paz
- first_name: Raghavendra G.
full_name: Mirmira, Raghavendra G.
last_name: Mirmira
- first_name: Antonia
full_name: Gutiérrez, Antonia
last_name: Gutiérrez
- first_name: Francisco J.
full_name: Alonso, Francisco J.
last_name: Alonso
- first_name: Juan A.
full_name: Segura, Juan A.
last_name: Segura
- first_name: José M.
full_name: Matés, José M.
last_name: Matés
- first_name: Gert
full_name: Lubec, Gert
last_name: Lubec
- first_name: Javier
full_name: Márquez, Javier
last_name: Márquez
citation:
ama: López De La Oliva AR, Campos-Sandoval JA, Gómez-García MC, et al. Nuclear translocation
of glutaminase GLS2 in human cancer cells associates with proliferation arrest
and differentiation. Scientific reports. 2020;10(1). doi:10.1038/s41598-020-58264-4
apa: López De La Oliva, A. R., Campos-Sandoval, J. A., Gómez-García, M. C., Cardona,
C., Martín-Rufián, M., Sialana, F. J., … Márquez, J. (2020). Nuclear translocation
of glutaminase GLS2 in human cancer cells associates with proliferation arrest
and differentiation. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-020-58264-4
chicago: López De La Oliva, Amada R., José A. Campos-Sandoval, María C. Gómez-García,
Carolina Cardona, Mercedes Martín-Rufián, Fernando J. Sialana, Laura Castilla,
et al. “Nuclear Translocation of Glutaminase GLS2 in Human Cancer Cells Associates
with Proliferation Arrest and Differentiation.” Scientific Reports. Springer
Nature, 2020. https://doi.org/10.1038/s41598-020-58264-4.
ieee: A. R. López De La Oliva et al., “Nuclear translocation of glutaminase
GLS2 in human cancer cells associates with proliferation arrest and differentiation,”
Scientific reports, vol. 10, no. 1. Springer Nature, 2020.
ista: López De La Oliva AR, Campos-Sandoval JA, Gómez-García MC, Cardona C, Martín-Rufián
M, Sialana FJ, Castilla L, Bae N, Lobo C, Peñalver A, García-Frutos M, Carro D,
Enrique V, Paz JC, Mirmira RG, Gutiérrez A, Alonso FJ, Segura JA, Matés JM, Lubec
G, Márquez J. 2020. Nuclear translocation of glutaminase GLS2 in human cancer
cells associates with proliferation arrest and differentiation. Scientific reports.
10(1), 2259.
mla: López De La Oliva, Amada R., et al. “Nuclear Translocation of Glutaminase GLS2
in Human Cancer Cells Associates with Proliferation Arrest and Differentiation.”
Scientific Reports, vol. 10, no. 1, 2259, Springer Nature, 2020, doi:10.1038/s41598-020-58264-4.
short: A.R. López De La Oliva, J.A. Campos-Sandoval, M.C. Gómez-García, C. Cardona,
M. Martín-Rufián, F.J. Sialana, L. Castilla, N. Bae, C. Lobo, A. Peñalver, M.
García-Frutos, D. Carro, V. Enrique, J.C. Paz, R.G. Mirmira, A. Gutiérrez, F.J.
Alonso, J.A. Segura, J.M. Matés, G. Lubec, J. Márquez, Scientific Reports 10 (2020).
date_created: 2020-02-16T23:00:49Z
date_published: 2020-02-10T00:00:00Z
date_updated: 2023-08-18T06:35:13Z
day: '10'
ddc:
- '570'
department:
- _id: CaBe
doi: 10.1038/s41598-020-58264-4
external_id:
isi:
- '000560694800012'
pmid:
- '32042057'
file:
- access_level: open_access
checksum: c780bd87476a9c9e12668ff66de3dc96
content_type: application/pdf
creator: dernst
date_created: 2020-02-18T07:43:21Z
date_updated: 2020-07-14T12:47:59Z
file_id: '7495'
file_name: 2020_ScientificReport_Lopez.pdf
file_size: 4703751
relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '1'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific reports
publication_identifier:
eissn:
- '20452322'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41598-020-80651-0
scopus_import: '1'
status: public
title: Nuclear translocation of glutaminase GLS2 in human cancer cells associates
with proliferation arrest and differentiation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2020'
...
---
_id: '7488'
abstract:
- lang: eng
text: Characteristic or classic phenotype of Cornelia de Lange syndrome (CdLS) is
associated with a recognisable facial pattern. However, the heterogeneity in causal
genes and the presence of overlapping syndromes have made it increasingly difficult
to diagnose only by clinical features. DeepGestalt technology, and its app Face2Gene,
is having a growing impact on the diagnosis and management of genetic diseases
by analysing the features of affected individuals. Here, we performed a phenotypic
study on a cohort of 49 individuals harbouring causative variants in known CdLS
genes in order to evaluate Face2Gene utility and sensitivity in the clinical diagnosis
of CdLS. Based on the profile images of patients, a diagnosis of CdLS was within
the top five predicted syndromes for 97.9% of our cases and even listed as first
prediction for 83.7%. The age of patients did not seem to affect the prediction
accuracy, whereas our results indicate a correlation between the clinical score
and affected genes. Furthermore, each gene presents a different pattern recognition
that may be used to develop new neural networks with the goal of separating different
genetic subtypes in CdLS. Overall, we conclude that computer-assisted image analysis
based on deep learning could support the clinical diagnosis of CdLS.
article_number: '1042'
article_processing_charge: No
article_type: original
author:
- first_name: Ana
full_name: Latorre-Pellicer, Ana
last_name: Latorre-Pellicer
- first_name: Ángela
full_name: Ascaso, Ángela
last_name: Ascaso
- first_name: Laura
full_name: Trujillano, Laura
last_name: Trujillano
- first_name: Marta
full_name: Gil-Salvador, Marta
last_name: Gil-Salvador
- first_name: Maria
full_name: Arnedo, Maria
last_name: Arnedo
- first_name: Cristina
full_name: Lucia-Campos, Cristina
last_name: Lucia-Campos
- first_name: Rebeca
full_name: Antoñanzas-Pérez, Rebeca
last_name: Antoñanzas-Pérez
- first_name: Iñigo
full_name: Marcos-Alcalde, Iñigo
last_name: Marcos-Alcalde
- first_name: Ilaria
full_name: Parenti, Ilaria
id: D93538B0-5B71-11E9-AC62-02EBE5697425
last_name: Parenti
- first_name: Gloria
full_name: Bueno-Lozano, Gloria
last_name: Bueno-Lozano
- first_name: Antonio
full_name: Musio, Antonio
last_name: Musio
- first_name: Beatriz
full_name: Puisac, Beatriz
last_name: Puisac
- first_name: Frank J.
full_name: Kaiser, Frank J.
last_name: Kaiser
- first_name: Feliciano J.
full_name: Ramos, Feliciano J.
last_name: Ramos
- first_name: Paulino
full_name: Gómez-Puertas, Paulino
last_name: Gómez-Puertas
- first_name: Juan
full_name: Pié, Juan
last_name: Pié
citation:
ama: Latorre-Pellicer A, Ascaso Á, Trujillano L, et al. Evaluating Face2Gene as
a tool to identify Cornelia de Lange syndrome by facial phenotypes. International
Journal of Molecular Sciences. 2020;21(3). doi:10.3390/ijms21031042
apa: Latorre-Pellicer, A., Ascaso, Á., Trujillano, L., Gil-Salvador, M., Arnedo,
M., Lucia-Campos, C., … Pié, J. (2020). Evaluating Face2Gene as a tool to identify
Cornelia de Lange syndrome by facial phenotypes. International Journal of Molecular
Sciences. MDPI. https://doi.org/10.3390/ijms21031042
chicago: Latorre-Pellicer, Ana, Ángela Ascaso, Laura Trujillano, Marta Gil-Salvador,
Maria Arnedo, Cristina Lucia-Campos, Rebeca Antoñanzas-Pérez, et al. “Evaluating
Face2Gene as a Tool to Identify Cornelia de Lange Syndrome by Facial Phenotypes.”
International Journal of Molecular Sciences. MDPI, 2020. https://doi.org/10.3390/ijms21031042.
ieee: A. Latorre-Pellicer et al., “Evaluating Face2Gene as a tool to identify
Cornelia de Lange syndrome by facial phenotypes,” International Journal of
Molecular Sciences, vol. 21, no. 3. MDPI, 2020.
ista: Latorre-Pellicer A, Ascaso Á, Trujillano L, Gil-Salvador M, Arnedo M, Lucia-Campos
C, Antoñanzas-Pérez R, Marcos-Alcalde I, Parenti I, Bueno-Lozano G, Musio A, Puisac
B, Kaiser FJ, Ramos FJ, Gómez-Puertas P, Pié J. 2020. Evaluating Face2Gene as
a tool to identify Cornelia de Lange syndrome by facial phenotypes. International
Journal of Molecular Sciences. 21(3), 1042.
mla: Latorre-Pellicer, Ana, et al. “Evaluating Face2Gene as a Tool to Identify Cornelia
de Lange Syndrome by Facial Phenotypes.” International Journal of Molecular
Sciences, vol. 21, no. 3, 1042, MDPI, 2020, doi:10.3390/ijms21031042.
short: A. Latorre-Pellicer, Á. Ascaso, L. Trujillano, M. Gil-Salvador, M. Arnedo,
C. Lucia-Campos, R. Antoñanzas-Pérez, I. Marcos-Alcalde, I. Parenti, G. Bueno-Lozano,
A. Musio, B. Puisac, F.J. Kaiser, F.J. Ramos, P. Gómez-Puertas, J. Pié, International
Journal of Molecular Sciences 21 (2020).
date_created: 2020-02-16T23:00:49Z
date_published: 2020-02-04T00:00:00Z
date_updated: 2023-08-18T06:35:41Z
day: '04'
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department:
- _id: GaNo
doi: 10.3390/ijms21031042
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publisher: MDPI
quality_controlled: '1'
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title: Evaluating Face2Gene as a tool to identify Cornelia de Lange syndrome by facial
phenotypes
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
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type: journal_article
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---
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abstract:
- lang: eng
text: 'In the present work, we consider the evolution of two fluids separated by
a sharp interface in the presence of surface tension—like, for example, the evolution
of oil bubbles in water. Our main result is a weak–strong uniqueness principle
for the corresponding free boundary problem for the incompressible Navier–Stokes
equation: as long as a strong solution exists, any varifold solution must coincide
with it. In particular, in the absence of physical singularities, the concept
of varifold solutions—whose global in time existence has been shown by Abels (Interfaces
Free Bound 9(1):31–65, 2007) for general initial data—does not introduce a mechanism
for non-uniqueness. The key ingredient of our approach is the construction of
a relative entropy functional capable of controlling the interface error. If the
viscosities of the two fluids do not coincide, even for classical (strong) solutions
the gradient of the velocity field becomes discontinuous at the interface, introducing
the need for a careful additional adaption of the relative entropy.'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
- first_name: Sebastian
full_name: Hensel, Sebastian
id: 4D23B7DA-F248-11E8-B48F-1D18A9856A87
last_name: Hensel
orcid: 0000-0001-7252-8072
citation:
ama: Fischer JL, Hensel S. Weak–strong uniqueness for the Navier–Stokes equation
for two fluids with surface tension. Archive for Rational Mechanics and Analysis.
2020;236:967-1087. doi:10.1007/s00205-019-01486-2
apa: Fischer, J. L., & Hensel, S. (2020). Weak–strong uniqueness for the Navier–Stokes
equation for two fluids with surface tension. Archive for Rational Mechanics
and Analysis. Springer Nature. https://doi.org/10.1007/s00205-019-01486-2
chicago: Fischer, Julian L, and Sebastian Hensel. “Weak–Strong Uniqueness for the
Navier–Stokes Equation for Two Fluids with Surface Tension.” Archive for Rational
Mechanics and Analysis. Springer Nature, 2020. https://doi.org/10.1007/s00205-019-01486-2.
ieee: J. L. Fischer and S. Hensel, “Weak–strong uniqueness for the Navier–Stokes
equation for two fluids with surface tension,” Archive for Rational Mechanics
and Analysis, vol. 236. Springer Nature, pp. 967–1087, 2020.
ista: Fischer JL, Hensel S. 2020. Weak–strong uniqueness for the Navier–Stokes equation
for two fluids with surface tension. Archive for Rational Mechanics and Analysis.
236, 967–1087.
mla: Fischer, Julian L., and Sebastian Hensel. “Weak–Strong Uniqueness for the Navier–Stokes
Equation for Two Fluids with Surface Tension.” Archive for Rational Mechanics
and Analysis, vol. 236, Springer Nature, 2020, pp. 967–1087, doi:10.1007/s00205-019-01486-2.
short: J.L. Fischer, S. Hensel, Archive for Rational Mechanics and Analysis 236
(2020) 967–1087.
date_created: 2020-02-16T23:00:50Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2023-09-07T13:30:45Z
day: '01'
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doi: 10.1007/s00205-019-01486-2
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language:
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month: '05'
oa: 1
oa_version: Published Version
page: 967-1087
project:
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call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
publication: Archive for Rational Mechanics and Analysis
publication_identifier:
eissn:
- '14320673'
issn:
- '00039527'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
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status: public
scopus_import: '1'
status: public
title: Weak–strong uniqueness for the Navier–Stokes equation for two fluids with surface
tension
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 236
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...