---
_id: '8373'
abstract:
- lang: eng
text: It is well known that special Kubo-Ando operator means admit divergence center
interpretations, moreover, they are also mean squared error estimators for certain
metrics on positive definite operators. In this paper we give a divergence center
interpretation for every symmetric Kubo-Ando mean. This characterization of the
symmetric means naturally leads to a definition of weighted and multivariate versions
of a large class of symmetric Kubo-Ando means. We study elementary properties
of these weighted multivariate means, and note in particular that in the special
case of the geometric mean we recover the weighted A#H-mean introduced by Kim,
Lawson, and Lim.
acknowledgement: "The authors are grateful to Milán Mosonyi for fruitful discussions
on the topic, and to the anonymous referee for his/her comments and suggestions.\r\nJ.
Pitrik was supported by the Hungarian Academy of Sciences Lendület-Momentum Grant
for Quantum Information Theory, No. 96 141, and by Hungarian National Research,
Development and Innovation Office (NKFIH) via grants no. K119442, no. K124152, and
no. KH129601. D. Virosztek was supported by the ISTFELLOW program of the Institute
of Science and Technology Austria (project code IC1027FELL01), by the European Union's
Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant
Agreement No. 846294, and partially supported by the Hungarian National Research,
Development and Innovation Office (NKFIH) via grants no. K124152, and no. KH129601."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: József
full_name: Pitrik, József
last_name: Pitrik
- first_name: Daniel
full_name: Virosztek, Daniel
id: 48DB45DA-F248-11E8-B48F-1D18A9856A87
last_name: Virosztek
orcid: 0000-0003-1109-5511
citation:
ama: Pitrik J, Virosztek D. A divergence center interpretation of general symmetric
Kubo-Ando means, and related weighted multivariate operator means. Linear Algebra
and its Applications. 2021;609:203-217. doi:10.1016/j.laa.2020.09.007
apa: Pitrik, J., & Virosztek, D. (2021). A divergence center interpretation
of general symmetric Kubo-Ando means, and related weighted multivariate operator
means. Linear Algebra and Its Applications. Elsevier. https://doi.org/10.1016/j.laa.2020.09.007
chicago: Pitrik, József, and Daniel Virosztek. “A Divergence Center Interpretation
of General Symmetric Kubo-Ando Means, and Related Weighted Multivariate Operator
Means.” Linear Algebra and Its Applications. Elsevier, 2021. https://doi.org/10.1016/j.laa.2020.09.007.
ieee: J. Pitrik and D. Virosztek, “A divergence center interpretation of general
symmetric Kubo-Ando means, and related weighted multivariate operator means,”
Linear Algebra and its Applications, vol. 609. Elsevier, pp. 203–217, 2021.
ista: Pitrik J, Virosztek D. 2021. A divergence center interpretation of general
symmetric Kubo-Ando means, and related weighted multivariate operator means. Linear
Algebra and its Applications. 609, 203–217.
mla: Pitrik, József, and Daniel Virosztek. “A Divergence Center Interpretation of
General Symmetric Kubo-Ando Means, and Related Weighted Multivariate Operator
Means.” Linear Algebra and Its Applications, vol. 609, Elsevier, 2021,
pp. 203–17, doi:10.1016/j.laa.2020.09.007.
short: J. Pitrik, D. Virosztek, Linear Algebra and Its Applications 609 (2021) 203–217.
date_created: 2020-09-11T08:35:50Z
date_published: 2021-01-15T00:00:00Z
date_updated: 2023-08-04T10:58:14Z
day: '15'
department:
- _id: LaEr
doi: 10.1016/j.laa.2020.09.007
ec_funded: 1
external_id:
arxiv:
- '2002.11678'
isi:
- '000581730500011'
intvolume: ' 609'
isi: 1
keyword:
- Kubo-Ando mean
- weighted multivariate mean
- barycenter
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2002.11678
month: '01'
oa: 1
oa_version: Preprint
page: 203-217
project:
- _id: 26A455A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '846294'
name: Geometric study of Wasserstein spaces and free probability
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Linear Algebra and its Applications
publication_identifier:
issn:
- 0024-3795
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: A divergence center interpretation of general symmetric Kubo-Ando means, and
related weighted multivariate operator means
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 609
year: '2021'
...
---
_id: '8429'
abstract:
- lang: eng
text: We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability
estimation, an alternative to marker discovery, and accurate genomic prediction,
taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability
parameters in the UK Biobank. We find that only ≤10% of the genetic variation
captured for height, body mass index, cardiovascular disease, and type 2 diabetes
is attributable to proximal regulatory regions within 10kb upstream of genes,
while 12-25% is attributed to coding regions, 32–44% to introns, and 22-28% to
distal 10-500kb upstream regions. Up to 24% of all cis and coding regions of each
chromosome are associated with each trait, with over 3,100 independent exonic
and intronic regions and over 5,400 independent regulatory regions having ≥95%
probability of contributing ≥0.001% to the genetic variance of these four traits.
Our open-source software (GMRM) provides a scalable alternative to current approaches
for biobank data.
acknowledgement: This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181),
and by core funding from the Institute of Science and Technology Austria. We would
like to thank the participants of the cohort studies, and the Ecole Polytechnique
Federal Lausanne (EPFL) SCITAS for their excellent compute resources, their generosity
with their time and the kindness of their support. P.M.V. acknowledges funding from
the Australian National Health and Medical Research Council (1113400) and the Australian
Research Council (FL180100072). L.R. acknowledges funding from the Kjell & Märta
Beijer Foundation (Stockholm, Sweden). We also would like to acknowledge Simone
Rubinacci, Oliver Delanau, Alexander Terenin, Eleonora Porcu, and Mike Goddard for
their useful comments and suggestions.
article_number: '6972'
article_processing_charge: No
article_type: original
author:
- first_name: Marion
full_name: Patxot, Marion
last_name: Patxot
- first_name: Daniel
full_name: Trejo Banos, Daniel
last_name: Trejo Banos
- first_name: Athanasios
full_name: Kousathanas, Athanasios
last_name: Kousathanas
- first_name: Etienne J
full_name: Orliac, Etienne J
last_name: Orliac
- first_name: Sven E
full_name: Ojavee, Sven E
last_name: Ojavee
- first_name: Gerhard
full_name: Moser, Gerhard
last_name: Moser
- first_name: Julia
full_name: Sidorenko, Julia
last_name: Sidorenko
- first_name: Zoltan
full_name: Kutalik, Zoltan
last_name: Kutalik
- first_name: Reedik
full_name: Magi, Reedik
last_name: Magi
- first_name: Peter M
full_name: Visscher, Peter M
last_name: Visscher
- first_name: Lars
full_name: Ronnegard, Lars
last_name: Ronnegard
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
citation:
ama: Patxot M, Trejo Banos D, Kousathanas A, et al. Probabilistic inference of the
genetic architecture underlying functional enrichment of complex traits. Nature
Communications. 2021;12(1). doi:10.1038/s41467-021-27258-9
apa: Patxot, M., Trejo Banos, D., Kousathanas, A., Orliac, E. J., Ojavee, S. E.,
Moser, G., … Robinson, M. R. (2021). Probabilistic inference of the genetic architecture
underlying functional enrichment of complex traits. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-021-27258-9
chicago: Patxot, Marion, Daniel Trejo Banos, Athanasios Kousathanas, Etienne J Orliac,
Sven E Ojavee, Gerhard Moser, Julia Sidorenko, et al. “Probabilistic Inference
of the Genetic Architecture Underlying Functional Enrichment of Complex Traits.”
Nature Communications. Springer Nature, 2021. https://doi.org/10.1038/s41467-021-27258-9.
ieee: M. Patxot et al., “Probabilistic inference of the genetic architecture
underlying functional enrichment of complex traits,” Nature Communications,
vol. 12, no. 1. Springer Nature, 2021.
ista: Patxot M, Trejo Banos D, Kousathanas A, Orliac EJ, Ojavee SE, Moser G, Sidorenko
J, Kutalik Z, Magi R, Visscher PM, Ronnegard L, Robinson MR. 2021. Probabilistic
inference of the genetic architecture underlying functional enrichment of complex
traits. Nature Communications. 12(1), 6972.
mla: Patxot, Marion, et al. “Probabilistic Inference of the Genetic Architecture
Underlying Functional Enrichment of Complex Traits.” Nature Communications,
vol. 12, no. 1, 6972, Springer Nature, 2021, doi:10.1038/s41467-021-27258-9.
short: M. Patxot, D. Trejo Banos, A. Kousathanas, E.J. Orliac, S.E. Ojavee, G. Moser,
J. Sidorenko, Z. Kutalik, R. Magi, P.M. Visscher, L. Ronnegard, M.R. Robinson,
Nature Communications 12 (2021).
date_created: 2020-09-17T10:52:38Z
date_published: 2021-11-30T00:00:00Z
date_updated: 2023-09-26T10:36:14Z
day: '30'
ddc:
- '610'
department:
- _id: MaRo
doi: 10.1038/s41467-021-27258-9
external_id:
isi:
- '000724450600023'
file:
- access_level: open_access
checksum: 384681be17aff902c149a48f52d13d4f
content_type: application/pdf
creator: cchlebak
date_created: 2021-12-06T07:47:11Z
date_updated: 2021-12-06T07:47:11Z
file_id: '10419'
file_name: 2021_NatComm_Paxtot.pdf
file_size: 6519771
relation: main_file
success: 1
file_date_updated: 2021-12-06T07:47:11Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '13063'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Probabilistic inference of the genetic architecture underlying functional enrichment
of complex traits
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2021'
...
---
_id: '8430'
abstract:
- lang: eng
text: While recent advancements in computation and modelling have improved the analysis
of complex traits, our understanding of the genetic basis of the time at symptom
onset remains limited. Here, we develop a Bayesian approach (BayesW) that provides
probabilistic inference of the genetic architecture of age-at-onset phenotypes
in a sampling scheme that facilitates biobank-scale time-to-event analyses. We
show in extensive simulation work the benefits BayesW provides in terms of number
of discoveries, model performance and genomic prediction. In the UK Biobank, we
find many thousands of common genomic regions underlying the age-at-onset of high
blood pressure (HBP), cardiac disease (CAD), and type-2 diabetes (T2D), and for
the genetic basis of onset reflecting the underlying genetic liability to disease.
Age-at-menopause and age-at-menarche are also highly polygenic, but with higher
variance contributed by low frequency variants. Genomic prediction into the Estonian
Biobank data shows that BayesW gives higher prediction accuracy than other approaches.
acknowledgement: This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181),
and by core funding from the Institute of Science and Technology Austria and the
University of Lausanne; the work of KF was supported by the grant PUT1665 by the
Estonian Research Council. We would like to thank Mike Goddard for comments which
greatly improved the work, the participants of the cohort studies, and the Ecole
Polytechnique Federal Lausanne (EPFL) SCITAS for their excellent compute resources,
their generosity with their time and the kindness of their support.
article_number: '2337'
article_processing_charge: No
author:
- first_name: Sven E
full_name: Ojavee, Sven E
last_name: Ojavee
- first_name: Athanasios
full_name: Kousathanas, Athanasios
last_name: Kousathanas
- first_name: Daniel
full_name: Trejo Banos, Daniel
last_name: Trejo Banos
- first_name: Etienne J
full_name: Orliac, Etienne J
last_name: Orliac
- first_name: Marion
full_name: Patxot, Marion
last_name: Patxot
- first_name: Kristi
full_name: Lall, Kristi
last_name: Lall
- first_name: Reedik
full_name: Magi, Reedik
last_name: Magi
- first_name: Krista
full_name: Fischer, Krista
last_name: Fischer
- first_name: Zoltan
full_name: Kutalik, Zoltan
last_name: Kutalik
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
citation:
ama: Ojavee SE, Kousathanas A, Trejo Banos D, et al. Genomic architecture and prediction
of censored time-to-event phenotypes with a Bayesian genome-wide analysis. Nature
Communications. 2021;12(1). doi:10.1038/s41467-021-22538-w
apa: Ojavee, S. E., Kousathanas, A., Trejo Banos, D., Orliac, E. J., Patxot, M.,
Lall, K., … Robinson, M. R. (2021). Genomic architecture and prediction of censored
time-to-event phenotypes with a Bayesian genome-wide analysis. Nature Communications.
Nature Research. https://doi.org/10.1038/s41467-021-22538-w
chicago: Ojavee, Sven E, Athanasios Kousathanas, Daniel Trejo Banos, Etienne J Orliac,
Marion Patxot, Kristi Lall, Reedik Magi, Krista Fischer, Zoltan Kutalik, and Matthew
Richard Robinson. “Genomic Architecture and Prediction of Censored Time-to-Event
Phenotypes with a Bayesian Genome-Wide Analysis.” Nature Communications.
Nature Research, 2021. https://doi.org/10.1038/s41467-021-22538-w.
ieee: S. E. Ojavee et al., “Genomic architecture and prediction of censored
time-to-event phenotypes with a Bayesian genome-wide analysis,” Nature Communications,
vol. 12, no. 1. Nature Research, 2021.
ista: Ojavee SE, Kousathanas A, Trejo Banos D, Orliac EJ, Patxot M, Lall K, Magi
R, Fischer K, Kutalik Z, Robinson MR. 2021. Genomic architecture and prediction
of censored time-to-event phenotypes with a Bayesian genome-wide analysis. Nature
Communications. 12(1), 2337.
mla: Ojavee, Sven E., et al. “Genomic Architecture and Prediction of Censored Time-to-Event
Phenotypes with a Bayesian Genome-Wide Analysis.” Nature Communications,
vol. 12, no. 1, 2337, Nature Research, 2021, doi:10.1038/s41467-021-22538-w.
short: S.E. Ojavee, A. Kousathanas, D. Trejo Banos, E.J. Orliac, M. Patxot, K. Lall,
R. Magi, K. Fischer, Z. Kutalik, M.R. Robinson, Nature Communications 12 (2021).
date_created: 2020-09-17T10:53:00Z
date_published: 2021-04-20T00:00:00Z
date_updated: 2023-08-04T11:00:17Z
day: '20'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1038/s41467-021-22538-w
external_id:
isi:
- '000642509600006'
file:
- access_level: open_access
checksum: eca8b9ae713835c5b785211dd08d8a2e
content_type: application/pdf
creator: kschuh
date_created: 2021-05-04T15:07:50Z
date_updated: 2021-05-04T15:07:50Z
file_id: '9372'
file_name: 2021_nature_communications_Ojavee.pdf
file_size: 6474239
relation: main_file
success: 1
file_date_updated: 2021-05-04T15:07:50Z
has_accepted_license: '1'
intvolume: ' 12'
isi: 1
issue: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A
grant_number: PCEGP3_181181
name: Improving estimation and prediction of common complex disease risk
publication: Nature Communications
publication_identifier:
eissn:
- '20411723'
publication_status: published
publisher: Nature Research
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/predicting-the-onset-of-diseases/
scopus_import: '1'
status: public
title: Genomic architecture and prediction of censored time-to-event phenotypes with
a Bayesian genome-wide analysis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2021'
...
---
_id: '8544'
abstract:
- lang: eng
text: The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic
branches, yet this hypothesis has not been causally tested in vivo in the mammalian
brain. Presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2
mediate synaptogenesis between granule cells and Purkinje cells in the molecular
layer of the cerebellar cortex. Here we show that sparse but not global knockout
of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular
layer and overelaboration in the superficial molecular layer. Developmental, overexpression,
structure-function, and genetic epistasis analyses indicate that dendrite morphogenesis
defects result from competitive synaptogenesis in a Cbln1/GluD2-dependent manner.
A generative model of dendritic growth based on competitive synaptogenesis largely
recapitulates GluD2 sparse and global knockout phenotypes. Our results support
the synaptotrophic hypothesis at initial stages of dendrite development, suggest
a second mode in which cumulative synapse formation inhibits further dendrite
growth, and highlight the importance of competition in dendrite morphogenesis.
acknowledgement: We thank M. Mishina for GluD2fl frozen embryos, T.C. Südhof and J.I.
Morgan for Cbln1fl mice, L. Anderson for help in generating the MADM alleles, W.
Joo for a previously unpublished construct, M. Yuzaki, K. Shen, J. Ding, and members
of the Luo lab, including J.M. Kebschull, H. Li, J. Li, T. Li, C.M. McLaughlin,
D. Pederick, J. Ren, D.C. Wang and C. Xu for discussions and critiques of the manuscript,
and M. Yuzaki for supporting Y.H.T. during the final phase of this project. Y.H.T.
was supported by a JSPS fellowship; S.A.S. was supported by a Stanford Graduate
Fellowship and an NSF Predoctoral Fellowship; L.J. is supported by a Stanford Graduate
Fellowship and an NSF Predoctoral Fellowship; M.J.W. is supported by a Burroughs
Wellcome Fund CASI Award. This work was supported by an NIH grant (R01-NS050538)
to L.L.; the European Research Council (ERC) under the European Union's Horizon
2020 research and innovations programme (No. 725780 LinPro) to S.H.; and Simons
and James S. McDonnell Foundations and an NSF CAREER award to S.G.; L.L. is an HHMI
investigator.
article_processing_charge: No
article_type: original
author:
- first_name: Yukari H.
full_name: Takeo, Yukari H.
last_name: Takeo
- first_name: S. Andrew
full_name: Shuster, S. Andrew
last_name: Shuster
- first_name: Linnie
full_name: Jiang, Linnie
last_name: Jiang
- first_name: Miley
full_name: Hu, Miley
last_name: Hu
- first_name: David J.
full_name: Luginbuhl, David J.
last_name: Luginbuhl
- first_name: Thomas
full_name: Rülicke, Thomas
last_name: Rülicke
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Mark J.
full_name: Wagner, Mark J.
last_name: Wagner
- first_name: Surya
full_name: Ganguli, Surya
last_name: Ganguli
- first_name: Liqun
full_name: Luo, Liqun
last_name: Luo
citation:
ama: Takeo YH, Shuster SA, Jiang L, et al. GluD2- and Cbln1-mediated competitive
synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
2021;109(4):P629-644.E8. doi:10.1016/j.neuron.2020.11.028
apa: Takeo, Y. H., Shuster, S. A., Jiang, L., Hu, M., Luginbuhl, D. J., Rülicke,
T., … Luo, L. (2021). GluD2- and Cbln1-mediated competitive synaptogenesis shapes
the dendritic arbors of cerebellar Purkinje cells. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.11.028
chicago: Takeo, Yukari H., S. Andrew Shuster, Linnie Jiang, Miley Hu, David J. Luginbuhl,
Thomas Rülicke, Ximena Contreras, et al. “GluD2- and Cbln1-Mediated Competitive
Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” Neuron.
Elsevier, 2021. https://doi.org/10.1016/j.neuron.2020.11.028.
ieee: Y. H. Takeo et al., “GluD2- and Cbln1-mediated competitive synaptogenesis
shapes the dendritic arbors of cerebellar Purkinje cells,” Neuron, vol.
109, no. 4. Elsevier, p. P629–644.E8, 2021.
ista: Takeo YH, Shuster SA, Jiang L, Hu M, Luginbuhl DJ, Rülicke T, Contreras X,
Hippenmeyer S, Wagner MJ, Ganguli S, Luo L. 2021. GluD2- and Cbln1-mediated competitive
synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron.
109(4), P629–644.E8.
mla: Takeo, Yukari H., et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis
Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” Neuron, vol.
109, no. 4, Elsevier, 2021, p. P629–644.E8, doi:10.1016/j.neuron.2020.11.028.
short: Y.H. Takeo, S.A. Shuster, L. Jiang, M. Hu, D.J. Luginbuhl, T. Rülicke, X.
Contreras, S. Hippenmeyer, M.J. Wagner, S. Ganguli, L. Luo, Neuron 109 (2021)
P629–644.E8.
date_created: 2020-09-21T11:59:47Z
date_published: 2021-02-17T00:00:00Z
date_updated: 2024-03-06T12:12:48Z
day: '17'
department:
- _id: SiHi
doi: 10.1016/j.neuron.2020.11.028
ec_funded: 1
intvolume: ' 109'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.06.14.151258
month: '02'
oa: 1
oa_version: Preprint
page: P629-644.E8
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Neuron
publication_identifier:
eissn:
- 1097-4199
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors
of cerebellar Purkinje cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 109
year: '2021'
...
---
_id: '8546'
abstract:
- lang: eng
text: Brain neurons arise from relatively few progenitors generating an enormous
diversity of neuronal types. Nonetheless, a cardinal feature of mammalian brain
neurogenesis is thought to be that excitatory and inhibitory neurons derive from
separate, spatially segregated progenitors. Whether bi-potential progenitors with
an intrinsic capacity to generate both lineages exist and how such a fate decision
may be regulated are unknown. Using cerebellar development as a model, we discover
that individual progenitors can give rise to both inhibitory and excitatory lineages.
Gradations of Notch activity determine the fates of the progenitors and their
daughters. Daughters with the highest levels of Notch activity retain the progenitor
fate, while intermediate levels of Notch activity generate inhibitory neurons,
and daughters with very low levels of Notch signaling adopt the excitatory fate.
Therefore, Notch-mediated binary cell fate choice is a mechanism for regulating
the ratio of excitatory to inhibitory neurons from common progenitors.
acknowledgement: This work was supported by the program “Investissements d’avenir”
ANR-10-IAIHU-06 , ICM , a Sorbonne Université Emergence grant, an Allen Distinguished
Investigator Award , and the Roger De Spoelberch Foundation Prize (to B.A.H.); Armenise-Harvard
Foundation , AIRC , and CARITRO (to L.T.); and the European Research Council under
the European Union’s Horizon 2020 research and innovation programme grant agreement
no. 725780 LinPro (to S.H.). T.Z. and T.L. were supported by doctoral fellowships
from the China Scholarship Council and A.H.H. by a doctoral DOC fellowship of the
Austrian Academy of Sciences ( 24812 ). All animal work was conducted at the PHENO-ICMice
facility. The Core is supported by 2 “Investissements d’avenir” (ANR-10- IAIHU-06
and ANR-11-INBS-0011-NeurATRIS) and the “Fondation pour la Recherche Médicale.”
Light microscopy work was carried out at ICM’s imaging core facility, ICM.Quant,
and analysis of scRNA-seq data was carried out at ICM’s bioinformatics core facility,
iCONICS. We thank Paulina Ejsmont, Natalia Danda, and Nathalie De Geest for technical
support. We are grateful to Dr. Shahragim TAJBAKHSH for providing R26Rstop-NICD-nGFP
transgenic mice, Dr. Bart De Strooper for Psn1-deficient mice, Dr. Jean-Christophe
Marine for Gt(ROSA)26SortdTom reporter mice, and Dr. Martinez Barbera for Sox2CreERT2
mice. We also give thanks to Dr. Mikio Hoshino for providing Atoh1 and Ptf1a antibodies.
B.A.H. is an Einstein Visiting Fellow of the Berlin Institute of Health .
article_number: '109208'
article_processing_charge: No
article_type: original
author:
- first_name: Tingting
full_name: Zhang, Tingting
last_name: Zhang
- first_name: Tengyuan
full_name: Liu, Tengyuan
last_name: Liu
- first_name: Natalia
full_name: Mora, Natalia
last_name: Mora
- first_name: Justine
full_name: Guegan, Justine
last_name: Guegan
- first_name: Mathilde
full_name: Bertrand, Mathilde
last_name: Bertrand
- first_name: Ximena
full_name: Contreras, Ximena
id: 475990FE-F248-11E8-B48F-1D18A9856A87
last_name: Contreras
- first_name: Andi H
full_name: Hansen, Andi H
id: 38853E16-F248-11E8-B48F-1D18A9856A87
last_name: Hansen
- first_name: Carmen
full_name: Streicher, Carmen
id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
last_name: Streicher
- first_name: Marica
full_name: Anderle, Marica
last_name: Anderle
- first_name: Natasha
full_name: Danda, Natasha
last_name: Danda
- first_name: Luca
full_name: Tiberi, Luca
last_name: Tiberi
- first_name: Simon
full_name: Hippenmeyer, Simon
id: 37B36620-F248-11E8-B48F-1D18A9856A87
last_name: Hippenmeyer
orcid: 0000-0003-2279-1061
- first_name: Bassem A.
full_name: Hassan, Bassem A.
last_name: Hassan
citation:
ama: Zhang T, Liu T, Mora N, et al. Generation of excitatory and inhibitory neurons
from common progenitors via Notch signaling in the cerebellum. Cell Reports.
2021;35(10). doi:10.1016/j.celrep.2021.109208
apa: Zhang, T., Liu, T., Mora, N., Guegan, J., Bertrand, M., Contreras, X., … Hassan,
B. A. (2021). Generation of excitatory and inhibitory neurons from common progenitors
via Notch signaling in the cerebellum. Cell Reports. Elsevier. https://doi.org/10.1016/j.celrep.2021.109208
chicago: Zhang, Tingting, Tengyuan Liu, Natalia Mora, Justine Guegan, Mathilde Bertrand,
Ximena Contreras, Andi H Hansen, et al. “Generation of Excitatory and Inhibitory
Neurons from Common Progenitors via Notch Signaling in the Cerebellum.” Cell
Reports. Elsevier, 2021. https://doi.org/10.1016/j.celrep.2021.109208.
ieee: T. Zhang et al., “Generation of excitatory and inhibitory neurons from
common progenitors via Notch signaling in the cerebellum,” Cell Reports,
vol. 35, no. 10. Elsevier, 2021.
ista: Zhang T, Liu T, Mora N, Guegan J, Bertrand M, Contreras X, Hansen AH, Streicher
C, Anderle M, Danda N, Tiberi L, Hippenmeyer S, Hassan BA. 2021. Generation of
excitatory and inhibitory neurons from common progenitors via Notch signaling
in the cerebellum. Cell Reports. 35(10), 109208.
mla: Zhang, Tingting, et al. “Generation of Excitatory and Inhibitory Neurons from
Common Progenitors via Notch Signaling in the Cerebellum.” Cell Reports,
vol. 35, no. 10, 109208, Elsevier, 2021, doi:10.1016/j.celrep.2021.109208.
short: T. Zhang, T. Liu, N. Mora, J. Guegan, M. Bertrand, X. Contreras, A.H. Hansen,
C. Streicher, M. Anderle, N. Danda, L. Tiberi, S. Hippenmeyer, B.A. Hassan, Cell
Reports 35 (2021).
date_created: 2020-09-21T12:00:48Z
date_published: 2021-06-08T00:00:00Z
date_updated: 2023-08-04T11:00:48Z
day: '08'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.celrep.2021.109208
ec_funded: 1
external_id:
isi:
- '000659894300001'
pmid:
- '34107249 '
file:
- access_level: open_access
checksum: 7def3d42ebc8f5675efb6f38819e3e2e
content_type: application/pdf
creator: cziletti
date_created: 2021-06-15T14:01:35Z
date_updated: 2021-06-15T14:01:35Z
file_id: '9554'
file_name: 2021_CellReports_Zhang.pdf
file_size: 8900385
relation: main_file
success: 1
file_date_updated: 2021-06-15T14:01:35Z
has_accepted_license: '1'
intvolume: ' 35'
isi: 1
issue: '10'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '725780'
name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 2625A13E-B435-11E9-9278-68D0E5697425
grant_number: '24812'
name: Molecular Mechanisms of Radial Neuronal Migration
publication: Cell Reports
publication_identifier:
eissn:
- ' 22111247'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
link:
- relation: earlier_version
url: https://doi.org/10.1101/2020.03.18.997205
scopus_import: '1'
status: public
title: Generation of excitatory and inhibitory neurons from common progenitors via
Notch signaling in the cerebellum
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 35
year: '2021'
...
---
_id: '8582'
abstract:
- lang: eng
text: "Cell and tissue polarization is fundamental for plant growth and morphogenesis.
The polar, cellular localization of Arabidopsis PIN‐FORMED (PIN) proteins is crucial
for their function in directional auxin transport. The clustering of PIN polar
cargoes within the plasma membrane has been proposed to be important for the maintenance
of their polar distribution. However, the more detailed features of PIN clusters
and the cellular requirements of cargo clustering remain unclear.\r\nHere, we
characterized PIN clusters in detail by means of multiple advanced microscopy
and quantification methods, such as 3D quantitative imaging or freeze‐fracture
replica labeling. The size and aggregation types of PIN clusters were determined
by electron microscopy at the nanometer level at different polar domains and at
different developmental stages, revealing a strong preference for clustering at
the polar domains.\r\nPharmacological and genetic studies revealed that PIN clusters
depend on phosphoinositol pathways, cytoskeletal structures and specific cell‐wall
components as well as connections between the cell wall and the plasma membrane.\r\nThis
study identifies the role of different cellular processes and structures in polar
cargo clustering and provides initial mechanistic insight into the maintenance
of polarity in plants and other systems."
acknowledged_ssus:
- _id: Bio
acknowledgement: We thank Dr Ingo Heilmann (Martin‐Luther‐University Halle‐Wittenberg)
for the XVE>>PIP5K1‐YFP line, Dr Brad Day (Michigan State University) for the ndr1‐1
mutant and the complementation lines, and Dr Patricia C. Zambryski (University of
California, Berkeley) for the 35S::P30‐GFP line, the Bioimaging team (IST Austria)
for assistance with imaging, group members for discussions, Martine De Cock for
help in preparing the manuscript and Nataliia Gnyliukh for critical reading and
revision of the manuscript. This project received funding from the European Research
Council (ERC) under the European Union's Horizon 2020 research and innovation program
(grant agreement No. 742985) and Comisión Nacional de Investigación Científica y
Tecnológica (Project CONICYT‐PAI 82130047). DvW received funding from the People
Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme
(FP7/2007‐2013) under REA grant agreement no. 291734.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Hongjiang
full_name: Li, Hongjiang
id: 33CA54A6-F248-11E8-B48F-1D18A9856A87
last_name: Li
orcid: 0000-0001-5039-9660
- first_name: Daniel
full_name: von Wangenheim, Daniel
id: 49E91952-F248-11E8-B48F-1D18A9856A87
last_name: von Wangenheim
orcid: 0000-0002-6862-1247
- first_name: Xixi
full_name: Zhang, Xixi
id: 61A66458-47E9-11EA-85BA-8AEAAF14E49A
last_name: Zhang
orcid: 0000-0001-7048-4627
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: Nasser
full_name: Darwish-Miranda, Nasser
id: 39CD9926-F248-11E8-B48F-1D18A9856A87
last_name: Darwish-Miranda
orcid: 0000-0002-8821-8236
- first_name: Satoshi
full_name: Naramoto, Satoshi
last_name: Naramoto
- first_name: Krzysztof T
full_name: Wabnik, Krzysztof T
id: 4DE369A4-F248-11E8-B48F-1D18A9856A87
last_name: Wabnik
orcid: 0000-0001-7263-0560
- first_name: Riet
full_name: de Rycke, Riet
last_name: de Rycke
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Daniel J
full_name: Gütl, Daniel J
id: 381929CE-F248-11E8-B48F-1D18A9856A87
last_name: Gütl
- first_name: Ricardo
full_name: Tejos, Ricardo
last_name: Tejos
- first_name: Peter
full_name: Grones, Peter
id: 399876EC-F248-11E8-B48F-1D18A9856A87
last_name: Grones
- first_name: Meiyu
full_name: Ke, Meiyu
last_name: Ke
- first_name: Xu
full_name: Chen, Xu
id: 4E5ADCAA-F248-11E8-B48F-1D18A9856A87
last_name: Chen
- first_name: Jan
full_name: Dettmer, Jan
last_name: Dettmer
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li H, von Wangenheim D, Zhang X, et al. Cellular requirements for PIN polar
cargo clustering in Arabidopsis thaliana. New Phytologist. 2021;229(1):351-369.
doi:10.1111/nph.16887
apa: Li, H., von Wangenheim, D., Zhang, X., Tan, S., Darwish-Miranda, N., Naramoto,
S., … Friml, J. (2021). Cellular requirements for PIN polar cargo clustering in
Arabidopsis thaliana. New Phytologist. Wiley. https://doi.org/10.1111/nph.16887
chicago: Li, Hongjiang, Daniel von Wangenheim, Xixi Zhang, Shutang Tan, Nasser Darwish-Miranda,
Satoshi Naramoto, Krzysztof T Wabnik, et al. “Cellular Requirements for PIN Polar
Cargo Clustering in Arabidopsis Thaliana.” New Phytologist. Wiley, 2021.
https://doi.org/10.1111/nph.16887.
ieee: H. Li et al., “Cellular requirements for PIN polar cargo clustering
in Arabidopsis thaliana,” New Phytologist, vol. 229, no. 1. Wiley, pp.
351–369, 2021.
ista: Li H, von Wangenheim D, Zhang X, Tan S, Darwish-Miranda N, Naramoto S, Wabnik
KT, de Rycke R, Kaufmann W, Gütl DJ, Tejos R, Grones P, Ke M, Chen X, Dettmer
J, Friml J. 2021. Cellular requirements for PIN polar cargo clustering in Arabidopsis
thaliana. New Phytologist. 229(1), 351–369.
mla: Li, Hongjiang, et al. “Cellular Requirements for PIN Polar Cargo Clustering
in Arabidopsis Thaliana.” New Phytologist, vol. 229, no. 1, Wiley, 2021,
pp. 351–69, doi:10.1111/nph.16887.
short: H. Li, D. von Wangenheim, X. Zhang, S. Tan, N. Darwish-Miranda, S. Naramoto,
K.T. Wabnik, R. de Rycke, W. Kaufmann, D.J. Gütl, R. Tejos, P. Grones, M. Ke,
X. Chen, J. Dettmer, J. Friml, New Phytologist 229 (2021) 351–369.
date_created: 2020-09-28T08:59:28Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-08-04T11:01:21Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
- _id: EM-Fac
- _id: Bio
- _id: EvBe
doi: 10.1111/nph.16887
ec_funded: 1
external_id:
isi:
- '000570187900001'
file:
- access_level: open_access
checksum: b45621607b4cab97eeb1605ab58e896e
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T09:44:17Z
date_updated: 2021-02-04T09:44:17Z
file_id: '9084'
file_name: 2021_NewPhytologist_Li.pdf
file_size: 4061962
relation: main_file
success: 1
file_date_updated: 2021-02-04T09:44:17Z
has_accepted_license: '1'
intvolume: ' 229'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 351-369
project:
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: New Phytologist
publication_identifier:
eissn:
- '14698137'
issn:
- 0028646X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 229
year: '2021'
...
---
_id: '8601'
abstract:
- lang: eng
text: We consider large non-Hermitian real or complex random matrices X with independent,
identically distributed centred entries. We prove that their local eigenvalue
statistics near the spectral edge, the unit circle, coincide with those of the
Ginibre ensemble, i.e. when the matrix elements of X are Gaussian. This result
is the non-Hermitian counterpart of the universality of the Tracy–Widom distribution
at the spectral edges of the Wigner ensemble.
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Giorgio
full_name: Cipolloni, Giorgio
id: 42198EFA-F248-11E8-B48F-1D18A9856A87
last_name: Cipolloni
orcid: 0000-0002-4901-7992
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Dominik J
full_name: Schröder, Dominik J
id: 408ED176-F248-11E8-B48F-1D18A9856A87
last_name: Schröder
orcid: 0000-0002-2904-1856
citation:
ama: Cipolloni G, Erdös L, Schröder DJ. Edge universality for non-Hermitian random
matrices. Probability Theory and Related Fields. 2021. doi:10.1007/s00440-020-01003-7
apa: Cipolloni, G., Erdös, L., & Schröder, D. J. (2021). Edge universality for
non-Hermitian random matrices. Probability Theory and Related Fields. Springer
Nature. https://doi.org/10.1007/s00440-020-01003-7
chicago: Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Edge Universality
for Non-Hermitian Random Matrices.” Probability Theory and Related Fields.
Springer Nature, 2021. https://doi.org/10.1007/s00440-020-01003-7.
ieee: G. Cipolloni, L. Erdös, and D. J. Schröder, “Edge universality for non-Hermitian
random matrices,” Probability Theory and Related Fields. Springer Nature,
2021.
ista: Cipolloni G, Erdös L, Schröder DJ. 2021. Edge universality for non-Hermitian
random matrices. Probability Theory and Related Fields.
mla: Cipolloni, Giorgio, et al. “Edge Universality for Non-Hermitian Random Matrices.”
Probability Theory and Related Fields, Springer Nature, 2021, doi:10.1007/s00440-020-01003-7.
short: G. Cipolloni, L. Erdös, D.J. Schröder, Probability Theory and Related Fields
(2021).
date_created: 2020-10-04T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2024-03-07T15:07:53Z
day: '01'
ddc:
- '510'
department:
- _id: LaEr
doi: 10.1007/s00440-020-01003-7
ec_funded: 1
external_id:
arxiv:
- '1908.00969'
isi:
- '000572724600002'
file:
- access_level: open_access
checksum: 611ae28d6055e1e298d53a57beb05ef4
content_type: application/pdf
creator: dernst
date_created: 2020-10-05T14:53:40Z
date_updated: 2020-10-05T14:53:40Z
file_id: '8612'
file_name: 2020_ProbTheory_Cipolloni.pdf
file_size: 497032
relation: main_file
success: 1
file_date_updated: 2020-10-05T14:53:40Z
has_accepted_license: '1'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
project:
- _id: B67AFEDC-15C9-11EA-A837-991A96BB2854
name: IST Austria Open Access Fund
- _id: 258DCDE6-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '338804'
name: Random matrices, universality and disordered quantum systems
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Probability Theory and Related Fields
publication_identifier:
eissn:
- '14322064'
issn:
- '01788051'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Edge universality for non-Hermitian random matrices
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2021'
...
---
_id: '8602'
abstract:
- lang: eng
text: Collective cell migration offers a rich field of study for non-equilibrium
physics and cellular biology, revealing phenomena such as glassy dynamics, pattern
formation and active turbulence. However, how mechanical and chemical signalling
are integrated at the cellular level to give rise to such collective behaviours
remains unclear. We address this by focusing on the highly conserved phenomenon
of spatiotemporal waves of density and extracellular signal-regulated kinase (ERK)
activation, which appear both in vitro and in vivo during collective cell migration
and wound healing. First, we propose a biophysical theory, backed by mechanical
and optogenetic perturbation experiments, showing that patterns can be quantitatively
explained by a mechanochemical coupling between active cellular tensions and the
mechanosensitive ERK pathway. Next, we demonstrate how this biophysical mechanism
can robustly induce long-ranged order and migration in a desired orientation,
and we determine the theoretically optimal wavelength and period for inducing
maximal migration towards free edges, which fits well with experimentally observed
dynamics. We thereby provide a bridge between the biophysical origin of spatiotemporal
instabilities and the design principles of robust and efficient long-ranged migration.
acknowledgement: We would like to thank G. Tkacik and all of the members of the Hannezo
and Hirashima groups for useful discussions, X. Trepat for help on traction force
microscopy and M. Matsuda for use of the lab facility. E.H. acknowledges grants
from the Austrian Science Fund (FWF) (P 31639) and the European Research Council
(851288). T.H. acknowledges a grant from JST, PRESTO (JPMJPR1949). This project
has received funding from the European Union’s Horizon 2020 research and innovation
programme under the Marie Skłodowska-Curie grant agreement no. 665385 (to D.B.),
from JSPS KAKENHI grant no. 17J02107 (to N.H.) and from the SPIRITS 2018 of Kyoto
University (to E.H. and T.H.).
article_processing_charge: No
article_type: original
author:
- first_name: Daniel R
full_name: Boocock, Daniel R
id: 453AF628-F248-11E8-B48F-1D18A9856A87
last_name: Boocock
orcid: 0000-0002-1585-2631
- first_name: Naoya
full_name: Hino, Naoya
last_name: Hino
- first_name: Natalia
full_name: Ruzickova, Natalia
id: D2761128-D73D-11E9-A1BF-BA0DE6697425
last_name: Ruzickova
- first_name: Tsuyoshi
full_name: Hirashima, Tsuyoshi
last_name: Hirashima
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. Theory of mechanochemical
patterning and optimal migration in cell monolayers. Nature Physics. 2021;17:267-274.
doi:10.1038/s41567-020-01037-7
apa: Boocock, D. R., Hino, N., Ruzickova, N., Hirashima, T., & Hannezo, E. B.
(2021). Theory of mechanochemical patterning and optimal migration in cell monolayers.
Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-020-01037-7
chicago: Boocock, Daniel R, Naoya Hino, Natalia Ruzickova, Tsuyoshi Hirashima, and
Edouard B Hannezo. “Theory of Mechanochemical Patterning and Optimal Migration
in Cell Monolayers.” Nature Physics. Springer Nature, 2021. https://doi.org/10.1038/s41567-020-01037-7.
ieee: D. R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, and E. B. Hannezo, “Theory
of mechanochemical patterning and optimal migration in cell monolayers,” Nature
Physics, vol. 17. Springer Nature, pp. 267–274, 2021.
ista: Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. 2021. Theory of
mechanochemical patterning and optimal migration in cell monolayers. Nature Physics.
17, 267–274.
mla: Boocock, Daniel R., et al. “Theory of Mechanochemical Patterning and Optimal
Migration in Cell Monolayers.” Nature Physics, vol. 17, Springer Nature,
2021, pp. 267–74, doi:10.1038/s41567-020-01037-7.
short: D.R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, E.B. Hannezo, Nature Physics
17 (2021) 267–274.
date_created: 2020-10-04T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2023-08-04T11:02:41Z
day: '01'
department:
- _id: EdHa
doi: 10.1038/s41567-020-01037-7
ec_funded: 1
external_id:
isi:
- '000573519500002'
intvolume: ' 17'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2020.05.15.096479
month: '02'
oa: 1
oa_version: Preprint
page: 267-274
project:
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: Nature Physics
publication_identifier:
eissn:
- '17452481'
issn:
- '17452473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/wound-healing-waves/
record:
- id: '12964'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Theory of mechanochemical patterning and optimal migration in cell monolayers
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2021'
...
---
_id: '8603'
abstract:
- lang: eng
text: We consider the Fröhlich polaron model in the strong coupling limit. It is
well‐known that to leading order the ground state energy is given by the (classical)
Pekar energy. In this work, we establish the subleading correction, describing
quantum fluctuation about the classical limit. Our proof applies to a model of
a confined polaron, where both the electron and the polarization field are restricted
to a set of finite volume, with linear size determined by the natural length scale
of the Pekar problem.
acknowledgement: Partial support through National Science Foundation GrantDMS-1363432
(R.L.F.) and the European Research Council (ERC) under the Euro-pean Union’s Horizon
2020 research and innovation programme (grant agreementNo 694227; R.S.), is acknowledged.
Open access funding enabled and organizedby Projekt DEAL.
article_processing_charge: No
article_type: original
author:
- first_name: Rupert
full_name: Frank, Rupert
last_name: Frank
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Frank R, Seiringer R. Quantum corrections to the Pekar asymptotics of a strongly
coupled polaron. Communications on Pure and Applied Mathematics. 2021;74(3):544-588.
doi:10.1002/cpa.21944
apa: Frank, R., & Seiringer, R. (2021). Quantum corrections to the Pekar asymptotics
of a strongly coupled polaron. Communications on Pure and Applied Mathematics.
Wiley. https://doi.org/10.1002/cpa.21944
chicago: Frank, Rupert, and Robert Seiringer. “Quantum Corrections to the Pekar
Asymptotics of a Strongly Coupled Polaron.” Communications on Pure and Applied
Mathematics. Wiley, 2021. https://doi.org/10.1002/cpa.21944.
ieee: R. Frank and R. Seiringer, “Quantum corrections to the Pekar asymptotics of
a strongly coupled polaron,” Communications on Pure and Applied Mathematics,
vol. 74, no. 3. Wiley, pp. 544–588, 2021.
ista: Frank R, Seiringer R. 2021. Quantum corrections to the Pekar asymptotics of
a strongly coupled polaron. Communications on Pure and Applied Mathematics. 74(3),
544–588.
mla: Frank, Rupert, and Robert Seiringer. “Quantum Corrections to the Pekar Asymptotics
of a Strongly Coupled Polaron.” Communications on Pure and Applied Mathematics,
vol. 74, no. 3, Wiley, 2021, pp. 544–88, doi:10.1002/cpa.21944.
short: R. Frank, R. Seiringer, Communications on Pure and Applied Mathematics 74
(2021) 544–588.
date_created: 2020-10-04T22:01:37Z
date_published: 2021-03-01T00:00:00Z
date_updated: 2023-08-04T11:02:16Z
day: '01'
ddc:
- '510'
department:
- _id: RoSe
doi: 10.1002/cpa.21944
ec_funded: 1
external_id:
isi:
- '000572991500001'
file:
- access_level: open_access
checksum: 5f665ffa6e6dd958aec5c3040cbcfa84
content_type: application/pdf
creator: dernst
date_created: 2021-03-11T10:03:30Z
date_updated: 2021-03-11T10:03:30Z
file_id: '9236'
file_name: 2021_CommPureApplMath_Frank.pdf
file_size: 334987
relation: main_file
success: 1
file_date_updated: 2021-03-11T10:03:30Z
has_accepted_license: '1'
intvolume: ' 74'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 544-588
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication: Communications on Pure and Applied Mathematics
publication_identifier:
eissn:
- '10970312'
issn:
- '00103640'
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantum corrections to the Pekar asymptotics of a strongly coupled polaron
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 74
year: '2021'
...
---
_id: '8606'
abstract:
- lang: eng
text: The leaf is a crucial organ evolved with remarkable morphological diversity
to maximize plant photosynthesis. The leaf shape is a key trait that affects photosynthesis,
flowering rates, disease resistance, and yield. Although many genes regulating
leaf development have been identified in the past years, the precise regulatory
architecture underlying the generation of diverse leaf shapes remains to be elucidated.
We used cotton as a reference model to probe the genetic framework underlying
divergent leaf forms. Comparative transcriptome analysis revealed that the GhARF16‐1
and GhKNOX2‐1 genes might be potential regulators of leaf shape. We functionally
characterized the auxin‐responsive factor ARF16‐1 acting upstream of GhKNOX2‐1
to determine leaf morphology in cotton. The transcription of GhARF16‐1 was significantly
higher in lobed‐leaved cotton than in smooth‐leaved cotton. Furthermore, the overexpression
of GhARF16‐1 led to the upregulation of GhKNOX2‐1 and resulted in more and deeper
serrations in cotton leaves, similar to the leaf shape of cotton plants overexpressing
GhKNOX2‐1. We found that GhARF16‐1 specifically bound to the promoter of GhKNOX2‐1
to induce its expression. The heterologous expression of GhARF16‐1 and GhKNOX2‐1
in Arabidopsis led to lobed and curly leaves, and a genetic analysis revealed
that GhKNOX2‐1 is epistatic to GhARF16‐1 in Arabidopsis, suggesting that the GhARF16‐1
and GhKNOX2‐1 interaction paradigm also functions to regulate leaf shape in Arabidopsis.
To our knowledge, our results uncover a novel mechanism by which auxin, through
the key component ARF16‐1 and its downstream‐activated gene KNOX2‐1, determines
leaf morphology in eudicots.
acknowledgement: We are thankful to Professor Yuxian Zhu from Wuhan University for
his extremely valuable remarks and helpful comments on the manuscript. This work
was supported by the Shaanxi Natural Science Foundation (2019JQ‐062 and 2020JQ‐410),
Shaanxi Youth Entrusted Talents Program (20190205), China Postdoctoral Science Foundation
(2018M640947, 2020T130394), Shaanxi Postdoctoral Project (2018BSHYDZZ76), Natural
Science Basic Research Plan in Shaanxi Province of China (2018JZ3006), Fundamental
Research Funds for the Central Universities (GK201903064, GK201901004, GK202002005
and GK202001004), and State Key Laboratory of Cotton Biology Open Fund (CB2020A12).
article_processing_charge: No
article_type: original
author:
- first_name: P
full_name: He, P
last_name: He
- first_name: Yuzhou
full_name: Zhang, Yuzhou
id: 3B6137F2-F248-11E8-B48F-1D18A9856A87
last_name: Zhang
orcid: 0000-0003-2627-6956
- first_name: H
full_name: Li, H
last_name: Li
- first_name: X
full_name: Fu, X
last_name: Fu
- first_name: H
full_name: Shang, H
last_name: Shang
- first_name: C
full_name: Zou, C
last_name: Zou
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: G
full_name: Xiao, G
last_name: Xiao
citation:
ama: He P, Zhang Y, Li H, et al. GhARF16-1 modulates leaf development by transcriptionally
regulating the GhKNOX2-1 gene in cotton. Plant Biotechnology Journal. 2021;19(3):548-562.
doi:10.1111/pbi.13484
apa: He, P., Zhang, Y., Li, H., Fu, X., Shang, H., Zou, C., … Xiao, G. (2021). GhARF16-1
modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene
in cotton. Plant Biotechnology Journal. Wiley. https://doi.org/10.1111/pbi.13484
chicago: He, P, Yuzhou Zhang, H Li, X Fu, H Shang, C Zou, Jiří Friml, and G Xiao.
“GhARF16-1 Modulates Leaf Development by Transcriptionally Regulating the GhKNOX2-1
Gene in Cotton.” Plant Biotechnology Journal. Wiley, 2021. https://doi.org/10.1111/pbi.13484.
ieee: P. He et al., “GhARF16-1 modulates leaf development by transcriptionally
regulating the GhKNOX2-1 gene in cotton,” Plant Biotechnology Journal,
vol. 19, no. 3. Wiley, pp. 548–562, 2021.
ista: He P, Zhang Y, Li H, Fu X, Shang H, Zou C, Friml J, Xiao G. 2021. GhARF16-1
modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene
in cotton. Plant Biotechnology Journal. 19(3), 548–562.
mla: He, P., et al. “GhARF16-1 Modulates Leaf Development by Transcriptionally Regulating
the GhKNOX2-1 Gene in Cotton.” Plant Biotechnology Journal, vol. 19, no.
3, Wiley, 2021, pp. 548–62, doi:10.1111/pbi.13484.
short: P. He, Y. Zhang, H. Li, X. Fu, H. Shang, C. Zou, J. Friml, G. Xiao, Plant
Biotechnology Journal 19 (2021) 548–562.
date_created: 2020-10-05T12:44:33Z
date_published: 2021-03-01T00:00:00Z
date_updated: 2023-08-04T11:03:10Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/pbi.13484
external_id:
isi:
- '000577682300001'
pmid:
- '32981232'
file:
- access_level: open_access
checksum: 63845be37fb962586e0c7773f2355970
content_type: application/pdf
creator: dernst
date_created: 2021-04-12T12:29:07Z
date_updated: 2021-04-12T12:29:07Z
file_id: '9321'
file_name: 2021_PlantBiotechJournal_He.pdf
file_size: 15691871
relation: main_file
success: 1
file_date_updated: 2021-04-12T12:29:07Z
has_accepted_license: '1'
intvolume: ' 19'
isi: 1
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 548-562
pmid: 1
publication: Plant Biotechnology Journal
publication_identifier:
issn:
- 1467-7644
- 1467-7652
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1
gene in cotton
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 19
year: '2021'
...
---
_id: '8608'
abstract:
- lang: eng
text: To adapt to the diverse array of biotic and abiotic cues, plants have evolved
sophisticated mechanisms to sense changes in environmental conditions and modulate
their growth. Growth-promoting hormones and defence signalling fine tune plant
development antagonistically. During host-pathogen interactions, this defence-growth
trade-off is mediated by the counteractive effects of the defence hormone salicylic
acid (SA) and the growth hormone auxin. Here we revealed an underlying mechanism
of SA regulating auxin signalling by constraining the plasma membrane dynamics
of PIN2 auxin efflux transporter in Arabidopsis thaliana roots. The lateral diffusion
of PIN2 proteins is constrained by SA signalling, during which PIN2 proteins are
condensed into hyperclusters depending on REM1.2-mediated nanodomain compartmentalisation.
Furthermore, membrane nanodomain compartmentalisation by SA or Remorin (REM) assembly
significantly suppressed clathrin-mediated endocytosis. Consequently, SA-induced
heterogeneous surface condensation disrupted asymmetric auxin distribution and
the resultant gravitropic response. Our results demonstrated a defence-growth
trade-off mechanism by which SA signalling crosstalked with auxin transport by
concentrating membrane-resident PIN2 into heterogeneous compartments.
acknowledgement: This work was supported by the National Key Research andDevelopment
Programme of China (2017YFA0506100), theNational Natural Science Foundation of China
(31870170 and31701168), and the Fok Ying Tung Education Foundation(161027) to XC;
NTU startup grant (M4081533) and NIM/01/2016 (NTU, Singapore) to YM. We thank Lei
Shi andZhongquan Lin for microscopy assistance.
article_processing_charge: No
article_type: original
author:
- first_name: M
full_name: Ke, M
last_name: Ke
- first_name: Z
full_name: Ma, Z
last_name: Ma
- first_name: D
full_name: Wang, D
last_name: Wang
- first_name: Y
full_name: Sun, Y
last_name: Sun
- first_name: C
full_name: Wen, C
last_name: Wen
- first_name: D
full_name: Huang, D
last_name: Huang
- first_name: Z
full_name: Chen, Z
last_name: Chen
- first_name: L
full_name: Yang, L
last_name: Yang
- first_name: Shutang
full_name: Tan, Shutang
id: 2DE75584-F248-11E8-B48F-1D18A9856A87
last_name: Tan
orcid: 0000-0002-0471-8285
- first_name: R
full_name: Li, R
last_name: Li
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Y
full_name: Miao, Y
last_name: Miao
- first_name: X
full_name: Chen, X
last_name: Chen
citation:
ama: Ke M, Ma Z, Wang D, et al. Salicylic acid regulates PIN2 auxin transporter
hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain
organization in Arabidopsis thaliana. New Phytologist. 2021;229(2):963-978.
doi:10.1111/nph.16915
apa: Ke, M., Ma, Z., Wang, D., Sun, Y., Wen, C., Huang, D., … Chen, X. (2021). Salicylic
acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth
via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. New
Phytologist. Wiley. https://doi.org/10.1111/nph.16915
chicago: Ke, M, Z Ma, D Wang, Y Sun, C Wen, D Huang, Z Chen, et al. “Salicylic Acid
Regulates PIN2 Auxin Transporter Hyper-Clustering and Root Gravitropic Growth
via Remorin-Dependent Lipid Nanodomain Organization in Arabidopsis Thaliana.”
New Phytologist. Wiley, 2021. https://doi.org/10.1111/nph.16915.
ieee: M. Ke et al., “Salicylic acid regulates PIN2 auxin transporter hyper-clustering
and root gravitropic growth via Remorin-dependent lipid nanodomain organization
in Arabidopsis thaliana,” New Phytologist, vol. 229, no. 2. Wiley, pp.
963–978, 2021.
ista: Ke M, Ma Z, Wang D, Sun Y, Wen C, Huang D, Chen Z, Yang L, Tan S, Li R, Friml
J, Miao Y, Chen X. 2021. Salicylic acid regulates PIN2 auxin transporter hyper-clustering
and root gravitropic growth via Remorin-dependent lipid nanodomain organization
in Arabidopsis thaliana. New Phytologist. 229(2), 963–978.
mla: Ke, M., et al. “Salicylic Acid Regulates PIN2 Auxin Transporter Hyper-Clustering
and Root Gravitropic Growth via Remorin-Dependent Lipid Nanodomain Organization
in Arabidopsis Thaliana.” New Phytologist, vol. 229, no. 2, Wiley, 2021,
pp. 963–78, doi:10.1111/nph.16915.
short: M. Ke, Z. Ma, D. Wang, Y. Sun, C. Wen, D. Huang, Z. Chen, L. Yang, S. Tan,
R. Li, J. Friml, Y. Miao, X. Chen, New Phytologist 229 (2021) 963–978.
date_created: 2020-10-05T12:45:36Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-09-05T16:06:24Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1111/nph.16915
external_id:
isi:
- '000573568000001'
pmid:
- '32901934'
file:
- access_level: open_access
checksum: d36b6a8c6fafab66264e0d27114dae63
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T09:53:16Z
date_updated: 2021-02-04T09:53:16Z
file_id: '9085'
file_name: 2021_NewPhytologist_Ke.pdf
file_size: 3674502
relation: main_file
success: 1
file_date_updated: 2021-02-04T09:53:16Z
has_accepted_license: '1'
intvolume: ' 229'
isi: 1
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 963-978
pmid: 1
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646x
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic
growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 229
year: '2021'
...
---
_id: '8673'
abstract:
- lang: eng
text: In RuCl3, inelastic neutron scattering and Raman spectroscopy reveal a continuum
of non-spin-wave excitations that persists to high temperature, suggesting the
presence of a spin liquid state on a honeycomb lattice. In the context of the
Kitaev model, finite magnetic fields introduce interactions between the elementary
excitations, and thus the effects of high magnetic fields that are comparable
to the spin-exchange energy scale must be explored. Here, we report measurements
of the magnetotropic coefficient—the thermodynamic coefficient associated with
magnetic anisotropy—over a wide range of magnetic fields and temperatures. We
find that magnetic field and temperature compete to determine the magnetic response
in a way that is independent of the large intrinsic exchange-interaction energy.
This emergent scale-invariant magnetic anisotropy provides evidence for a high
degree of exchange frustration that favours the formation of a spin liquid state
in RuCl3.
acknowledgement: We thank M. Baenitz, A. Bangura, R. Coldea, G. Jackeli, S. Kivelson,
S. Nagler, R. Valenti, C. Varma, S. Winter and J. Zaanen for insightful discussions.
Samples were grown at the Max Planck Institute for Chemical Physics of Solids. The
d.c.-field measurements were made at the National High Magnetic Field Laboratory
(NHMFL) in Tallahassee, FL. The pulsed-field measurements were made in the Pulsed
Field Facility of the NHMFL in Los Alamos, NM. All work at the NHMFL is supported
through the National Science Foundation Cooperative Agreement nos. DMR-1157490 and
DMR-1644779, the US Department of Energy and the State of Florida. R.D.M. acknowledges
support from LANL LDRD-DR 20160085 Topology and Strong Correlations. M.C. acknowledges
support from the Department of Energy ‘Science of 100 tesla’ BES programme for high-field
experiments. X-ray data acquisition and analysis was performed at Cornell University.
Research conducted at the Cornell High Energy Synchrotron Source (CHESS) is supported
by the National Science Foundation under award no. DMR-1332208. B.J.R. acknowledges
support from the Institute for Quantum Matter, an Energy Frontier Research Center
funded by the US Department of Energy, Office of Science, Office of Basic Energy
Sciences under award no. DE-SC0019331. Y.L. acknowledges support from the US Department
of Energy through the LANL/LDRD programme and the G.T. Seaborg institute. J.C.P.
is supported by a Gabilan Stanford Graduate Fellowship and an NSF Graduate Research
Fellowship (grant no. DGE-114747). P.J.W.M. acknowledges funding from the Swiss
National Science Foundation through project no. PP00P2-176789.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Kimberly A
full_name: Modic, Kimberly A
id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
last_name: Modic
orcid: 0000-0001-9760-3147
- first_name: Ross D.
full_name: McDonald, Ross D.
last_name: McDonald
- first_name: J.P.C.
full_name: Ruff, J.P.C.
last_name: Ruff
- first_name: Maja D.
full_name: Bachmann, Maja D.
last_name: Bachmann
- first_name: You
full_name: Lai, You
last_name: Lai
- first_name: Johanna C.
full_name: Palmstrom, Johanna C.
last_name: Palmstrom
- first_name: David
full_name: Graf, David
last_name: Graf
- first_name: Mun K.
full_name: Chan, Mun K.
last_name: Chan
- first_name: F.F.
full_name: Balakirev, F.F.
last_name: Balakirev
- first_name: J.B.
full_name: Betts, J.B.
last_name: Betts
- first_name: G.S.
full_name: Boebinger, G.S.
last_name: Boebinger
- first_name: Marcus
full_name: Schmidt, Marcus
last_name: Schmidt
- first_name: Michael J.
full_name: Lawler, Michael J.
last_name: Lawler
- first_name: D.A.
full_name: Sokolov, D.A.
last_name: Sokolov
- first_name: Philip J.W.
full_name: Moll, Philip J.W.
last_name: Moll
- first_name: B.J.
full_name: Ramshaw, B.J.
last_name: Ramshaw
- first_name: Arkady
full_name: Shekhter, Arkady
last_name: Shekhter
citation:
ama: Modic KA, McDonald RD, Ruff JPC, et al. Scale-invariant magnetic anisotropy
in RuCl3 at high magnetic fields. Nature Physics. 2021;17:240-244. doi:10.1038/s41567-020-1028-0
apa: Modic, K. A., McDonald, R. D., Ruff, J. P. C., Bachmann, M. D., Lai, Y., Palmstrom,
J. C., … Shekhter, A. (2021). Scale-invariant magnetic anisotropy in RuCl3 at
high magnetic fields. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-020-1028-0
chicago: Modic, Kimberly A, Ross D. McDonald, J.P.C. Ruff, Maja D. Bachmann, You
Lai, Johanna C. Palmstrom, David Graf, et al. “Scale-Invariant Magnetic Anisotropy
in RuCl3 at High Magnetic Fields.” Nature Physics. Springer Nature, 2021.
https://doi.org/10.1038/s41567-020-1028-0.
ieee: K. A. Modic et al., “Scale-invariant magnetic anisotropy in RuCl3 at
high magnetic fields,” Nature Physics, vol. 17. Springer Nature, pp. 240–244,
2021.
ista: Modic KA, McDonald RD, Ruff JPC, Bachmann MD, Lai Y, Palmstrom JC, Graf D,
Chan MK, Balakirev FF, Betts JB, Boebinger GS, Schmidt M, Lawler MJ, Sokolov DA,
Moll PJW, Ramshaw BJ, Shekhter A. 2021. Scale-invariant magnetic anisotropy in
RuCl3 at high magnetic fields. Nature Physics. 17, 240–244.
mla: Modic, Kimberly A., et al. “Scale-Invariant Magnetic Anisotropy in RuCl3 at
High Magnetic Fields.” Nature Physics, vol. 17, Springer Nature, 2021,
pp. 240–44, doi:10.1038/s41567-020-1028-0.
short: K.A. Modic, R.D. McDonald, J.P.C. Ruff, M.D. Bachmann, Y. Lai, J.C. Palmstrom,
D. Graf, M.K. Chan, F.F. Balakirev, J.B. Betts, G.S. Boebinger, M. Schmidt, M.J.
Lawler, D.A. Sokolov, P.J.W. Moll, B.J. Ramshaw, A. Shekhter, Nature Physics 17
(2021) 240–244.
date_created: 2020-10-18T22:01:37Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2023-08-04T11:03:39Z
day: '01'
department:
- _id: KiMo
doi: 10.1038/s41567-020-1028-0
external_id:
arxiv:
- '2005.04228'
isi:
- '000575344700003'
intvolume: ' 17'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.04228
month: '02'
oa: 1
oa_version: Preprint
page: 240-244
publication: Nature Physics
publication_identifier:
eissn:
- '17452481'
issn:
- '17452473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 17
year: '2021'
...
---
_id: '8689'
abstract:
- lang: eng
text: 'This paper continues the discussion started in [CK19] concerning Arnold''s
legacy on classical KAM theory and (some of) its modern developments. We prove
a detailed and explicit `global'' Arnold''s KAM Theorem, which yields, in particular,
the Whitney conjugacy of a non{degenerate, real{analytic, nearly-integrable Hamiltonian
system to an integrable system on a closed, nowhere dense, positive measure subset
of the phase space. Detailed measure estimates on the Kolmogorov''s set are provided
in the case the phase space is: (A) a uniform neighbourhood of an arbitrary (bounded)
set times the d-torus and (B) a domain with C2 boundary times the d-torus. All
constants are explicitly given.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Luigi
full_name: Chierchia, Luigi
last_name: Chierchia
- first_name: Edmond
full_name: Koudjinan, Edmond
id: 52DF3E68-AEFA-11EA-95A4-124A3DDC885E
last_name: Koudjinan
orcid: 0000-0003-2640-4049
citation:
ama: Chierchia L, Koudjinan E. V.I. Arnold’s “‘Global’” KAM theorem and geometric
measure estimates. Regular and Chaotic Dynamics. 2021;26(1):61-88. doi:10.1134/S1560354721010044
apa: Chierchia, L., & Koudjinan, E. (2021). V.I. Arnold’s “‘Global’” KAM theorem
and geometric measure estimates. Regular and Chaotic Dynamics. Springer
Nature. https://doi.org/10.1134/S1560354721010044
chicago: Chierchia, Luigi, and Edmond Koudjinan. “V.I. Arnold’s ‘“Global”’ KAM Theorem
and Geometric Measure Estimates.” Regular and Chaotic Dynamics. Springer
Nature, 2021. https://doi.org/10.1134/S1560354721010044.
ieee: L. Chierchia and E. Koudjinan, “V.I. Arnold’s ‘“Global”’ KAM theorem and geometric
measure estimates,” Regular and Chaotic Dynamics, vol. 26, no. 1. Springer
Nature, pp. 61–88, 2021.
ista: Chierchia L, Koudjinan E. 2021. V.I. Arnold’s ‘“Global”’ KAM theorem and geometric
measure estimates. Regular and Chaotic Dynamics. 26(1), 61–88.
mla: Chierchia, Luigi, and Edmond Koudjinan. “V.I. Arnold’s ‘“Global”’ KAM Theorem
and Geometric Measure Estimates.” Regular and Chaotic Dynamics, vol. 26,
no. 1, Springer Nature, 2021, pp. 61–88, doi:10.1134/S1560354721010044.
short: L. Chierchia, E. Koudjinan, Regular and Chaotic Dynamics 26 (2021) 61–88.
date_created: 2020-10-21T14:56:47Z
date_published: 2021-02-03T00:00:00Z
date_updated: 2023-08-07T13:37:27Z
day: '03'
ddc:
- '515'
department:
- _id: VaKa
doi: 10.1134/S1560354721010044
external_id:
arxiv:
- '2010.13243'
isi:
- '000614454700004'
intvolume: ' 26'
isi: 1
issue: '1'
keyword:
- Nearly{integrable Hamiltonian systems
- perturbation theory
- KAM Theory
- Arnold's scheme
- Kolmogorov's set
- primary invariant tori
- Lagrangian tori
- measure estimates
- small divisors
- integrability on nowhere dense sets
- Diophantine frequencies.
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2010.13243
month: '02'
oa: 1
oa_version: Preprint
page: 61-88
publication: Regular and Chaotic Dynamics
publication_identifier:
issn:
- 1560-3547
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: V.I. Arnold's ''Global'' KAM theorem and geometric measure estimates
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 26
year: '2021'
...
---
_id: '8708'
abstract:
- lang: eng
text: The Mytilus complex of marine mussel species forms a mosaic of hybrid zones,
found across temperate regions of the globe. This allows us to study ‘replicated’
instances of secondary contact between closely related species. Previous work
on this complex has shown that local introgression is both widespread and highly
heterogeneous, and has identified SNPs that are outliers of differentiation between
lineages. Here, we developed an ancestry‐informative panel of such SNPs. We then
compared their frequencies in newly sampled populations, including samples from
within the hybrid zones, and parental populations at different distances from
the contact. Results show that close to the hybrid zones, some outlier loci are
near to fixation for the heterospecific allele, suggesting enhanced local introgression,
or the local sweep of a shared ancestral allele. Conversely, genomic cline analyses,
treating local parental populations as the reference, reveal a globally high concordance
among loci, albeit with a few signals of asymmetric introgression. Enhanced local
introgression at specific loci is consistent with the early transfer of adaptive
variants after contact, possibly including asymmetric bi‐stable variants (Dobzhansky‐Muller
incompatibilities), or haplotypes loaded with fewer deleterious mutations. Having
escaped one barrier, however, these variants can be trapped or delayed at the
next barrier, confining the introgression locally. These results shed light on
the decay of species barriers during phases of contact.
acknowledgement: Data used in this work were partly produced through the genotyping
and sequencing facilities of ISEM and LabEx CeMEB, an ANR ‘Investissements d'avenir’
program (ANR‐10‐LABX‐04‐01) This project benefited from the Montpellier Bioinformatics
Biodiversity platform supported by the LabEx CeMEB. We thank Norah Saarman, Grant
Pogson, Célia Gosset and Pierre‐Alexandre Gagnaire for providing samples. This work
was funded by a Languedoc‐Roussillon ‘Chercheur(se)s d'Avenir’ grant (Connect7 project).
P. Strelkov was supported by the Russian Science Foundation project 19‐74‐20024.
This is article 2020‐240 of Institut des Sciences de l'Evolution de Montpellier.
article_processing_charge: No
article_type: original
author:
- first_name: Alexis
full_name: Simon, Alexis
last_name: Simon
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: Tahani
full_name: El Ayari, Tahani
last_name: El Ayari
- first_name: Cathy
full_name: Liautard‐Haag, Cathy
last_name: Liautard‐Haag
- first_name: Petr
full_name: Strelkov, Petr
last_name: Strelkov
- first_name: John J
full_name: Welch, John J
last_name: Welch
- first_name: Nicolas
full_name: Bierne, Nicolas
last_name: Bierne
citation:
ama: Simon A, Fraisse C, El Ayari T, et al. How do species barriers decay? Concordance
and local introgression in mosaic hybrid zones of mussels. Journal of Evolutionary
Biology. 2021;34(1):208-223. doi:10.1111/jeb.13709
apa: Simon, A., Fraisse, C., El Ayari, T., Liautard‐Haag, C., Strelkov, P., Welch,
J. J., & Bierne, N. (2021). How do species barriers decay? Concordance and
local introgression in mosaic hybrid zones of mussels. Journal of Evolutionary
Biology. Wiley. https://doi.org/10.1111/jeb.13709
chicago: Simon, Alexis, Christelle Fraisse, Tahani El Ayari, Cathy Liautard‐Haag,
Petr Strelkov, John J Welch, and Nicolas Bierne. “How Do Species Barriers Decay?
Concordance and Local Introgression in Mosaic Hybrid Zones of Mussels.” Journal
of Evolutionary Biology. Wiley, 2021. https://doi.org/10.1111/jeb.13709.
ieee: A. Simon et al., “How do species barriers decay? Concordance and local
introgression in mosaic hybrid zones of mussels,” Journal of Evolutionary Biology,
vol. 34, no. 1. Wiley, pp. 208–223, 2021.
ista: Simon A, Fraisse C, El Ayari T, Liautard‐Haag C, Strelkov P, Welch JJ, Bierne
N. 2021. How do species barriers decay? Concordance and local introgression in
mosaic hybrid zones of mussels. Journal of Evolutionary Biology. 34(1), 208–223.
mla: Simon, Alexis, et al. “How Do Species Barriers Decay? Concordance and Local
Introgression in Mosaic Hybrid Zones of Mussels.” Journal of Evolutionary Biology,
vol. 34, no. 1, Wiley, 2021, pp. 208–23, doi:10.1111/jeb.13709.
short: A. Simon, C. Fraisse, T. El Ayari, C. Liautard‐Haag, P. Strelkov, J.J. Welch,
N. Bierne, Journal of Evolutionary Biology 34 (2021) 208–223.
date_created: 2020-10-25T23:01:20Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-08-04T11:04:11Z
day: '01'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1111/jeb.13709
external_id:
isi:
- '000579599700001'
pmid:
- '33045123'
intvolume: ' 34'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/818559
month: '01'
oa: 1
oa_version: Preprint
page: 208-223
pmid: 1
publication: Journal of Evolutionary Biology
publication_identifier:
eissn:
- '14209101'
issn:
- 1010061X
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '13073'
relation: research_data
status: public
scopus_import: '1'
status: public
title: How do species barriers decay? Concordance and local introgression in mosaic
hybrid zones of mussels
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 34
year: '2021'
...
---
_id: '8723'
abstract:
- lang: eng
text: Deep learning at scale is dominated by communication time. Distributing samples
across nodes usually yields the best performance, but poses scaling challenges
due to global information dissemination and load imbalance across uneven sample
lengths. State-of-the-art decentralized optimizers mitigate the problem, but require
more iterations to achieve the same accuracy as their globally-communicating counterparts.
We present Wait-Avoiding Group Model Averaging (WAGMA) SGD, a wait-avoiding stochastic
optimizer that reduces global communication via subgroup weight exchange. The
key insight is a combination of algorithmic changes to the averaging scheme and
the use of a group allreduce operation. We prove the convergence of WAGMA-SGD,
and empirically show that it retains convergence rates similar to Allreduce-SGD.
For evaluation, we train ResNet-50 on ImageNet; Transformer for machine translation;
and deep reinforcement learning for navigation at scale. Compared with state-of-the-art
decentralized SGD variants, WAGMA-SGD significantly improves training throughput
(e.g., 2.1× on 1,024 GPUs for reinforcement learning), and achieves the fastest
time-to-solution (e.g., the highest score using the shortest training time for
Transformer).
acknowledgement: "This project has received funding from the European Research Council
(ERC) under the European Union’s Hori-\r\nzon 2020 programme under Grant DAPP, Grant
678880; EPi-GRAM-HS, Grant 801039; and ERC Starting Grant ScaleML, Grant 805223.
The work of Tal Ben-Nun is supported by the Swiss National Science Foundation (Ambizione
Project No. 185778). The work of Nikoli Dryden is supported by the ETH Postdoctoral
Fellowship. The authors would like to thank the Swiss National Supercomputing Center
for providing the computing resources and technical support."
article_number: '9271898'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Shigang
full_name: Li, Shigang
last_name: Li
- first_name: Tal Ben-Nun
full_name: Tal Ben-Nun, Tal Ben-Nun
last_name: Tal Ben-Nun
- first_name: Giorgi
full_name: Nadiradze, Giorgi
id: 3279A00C-F248-11E8-B48F-1D18A9856A87
last_name: Nadiradze
- first_name: Salvatore Di
full_name: Girolamo, Salvatore Di
last_name: Girolamo
- first_name: Nikoli
full_name: Dryden, Nikoli
last_name: Dryden
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
- first_name: Torsten
full_name: Hoefler, Torsten
last_name: Hoefler
citation:
ama: Li S, Tal Ben-Nun TB-N, Nadiradze G, et al. Breaking (global) barriers in parallel
stochastic optimization with wait-avoiding group averaging. IEEE Transactions
on Parallel and Distributed Systems. 2021;32(7). doi:10.1109/TPDS.2020.3040606
apa: Li, S., Tal Ben-Nun, T. B.-N., Nadiradze, G., Girolamo, S. D., Dryden, N.,
Alistarh, D.-A., & Hoefler, T. (2021). Breaking (global) barriers in parallel
stochastic optimization with wait-avoiding group averaging. IEEE Transactions
on Parallel and Distributed Systems. IEEE. https://doi.org/10.1109/TPDS.2020.3040606
chicago: Li, Shigang, Tal Ben-Nun Tal Ben-Nun, Giorgi Nadiradze, Salvatore Di Girolamo,
Nikoli Dryden, Dan-Adrian Alistarh, and Torsten Hoefler. “Breaking (Global) Barriers
in Parallel Stochastic Optimization with Wait-Avoiding Group Averaging.” IEEE
Transactions on Parallel and Distributed Systems. IEEE, 2021. https://doi.org/10.1109/TPDS.2020.3040606.
ieee: S. Li et al., “Breaking (global) barriers in parallel stochastic optimization
with wait-avoiding group averaging,” IEEE Transactions on Parallel and Distributed
Systems, vol. 32, no. 7. IEEE, 2021.
ista: Li S, Tal Ben-Nun TB-N, Nadiradze G, Girolamo SD, Dryden N, Alistarh D-A,
Hoefler T. 2021. Breaking (global) barriers in parallel stochastic optimization
with wait-avoiding group averaging. IEEE Transactions on Parallel and Distributed
Systems. 32(7), 9271898.
mla: Li, Shigang, et al. “Breaking (Global) Barriers in Parallel Stochastic Optimization
with Wait-Avoiding Group Averaging.” IEEE Transactions on Parallel and Distributed
Systems, vol. 32, no. 7, 9271898, IEEE, 2021, doi:10.1109/TPDS.2020.3040606.
short: S. Li, T.B.-N. Tal Ben-Nun, G. Nadiradze, S.D. Girolamo, N. Dryden, D.-A.
Alistarh, T. Hoefler, IEEE Transactions on Parallel and Distributed Systems 32
(2021).
date_created: 2020-11-05T15:25:43Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2023-08-04T11:08:52Z
day: '01'
department:
- _id: DaAl
doi: 10.1109/TPDS.2020.3040606
ec_funded: 1
external_id:
arxiv:
- '2005.00124'
isi:
- '000621405200019'
intvolume: ' 32'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2005.00124
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: IEEE Transactions on Parallel and Distributed Systems
publication_identifier:
issn:
- '10459219'
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: '1'
status: public
title: Breaking (global) barriers in parallel stochastic optimization with wait-avoiding
group averaging
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 32
year: '2021'
...
---
_id: '8730'
abstract:
- lang: eng
text: P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict
at the blood–brain barrier (BBB) the brain distribution of the majority of currently
known molecularly targeted anticancer drugs. To improve brain delivery of dual
ABCB1/ABCG2 substrates, both ABCB1 and ABCG2 need to be inhibited simultaneously
at the BBB. We examined the feasibility of simultaneous ABCB1/ABCG2 inhibition
with i.v. co-infusion of erlotinib and tariquidar by studying brain distribution
of the model ABCB1/ABCG2 substrate [11C]erlotinib in mice and rhesus macaques
with PET. Tolerability of the erlotinib/tariquidar combination was assessed in
human embryonic stem cell-derived cerebral organoids. In mice and macaques, baseline
brain distribution of [11C]erlotinib was low (brain distribution volume, VT,brain < 0.3 mL/cm3).
Co-infusion of erlotinib and tariquidar increased VT,brain in mice by 3.0-fold
and in macaques by 3.4- to 5.0-fold, while infusion of erlotinib alone or tariquidar
alone led to less pronounced VT,brain increases in both species. Treatment of
cerebral organoids with erlotinib/tariquidar led to an induction of Caspase-3-dependent
apoptosis. Co-infusion of erlotinib/tariquidar may potentially allow for complete
ABCB1/ABCG2 inhibition at the BBB, while simultaneously achieving brain-targeted
EGFR inhibition. Our protocol may be applicable to enhance brain delivery of molecularly
targeted anticancer drugs for a more effective treatment of brain tumors.
article_processing_charge: No
article_type: original
author:
- first_name: N
full_name: Tournier, N
last_name: Tournier
- first_name: S
full_name: Goutal, S
last_name: Goutal
- first_name: S
full_name: Mairinger, S
last_name: Mairinger
- first_name: IH
full_name: Lozano, IH
last_name: Lozano
- first_name: T
full_name: Filip, T
last_name: Filip
- first_name: M
full_name: Sauberer, M
last_name: Sauberer
- first_name: F
full_name: Caillé, F
last_name: Caillé
- first_name: L
full_name: Breuil, L
last_name: Breuil
- first_name: J
full_name: Stanek, J
last_name: Stanek
- first_name: AF
full_name: Freeman, AF
last_name: Freeman
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
- first_name: C
full_name: Truillet, C
last_name: Truillet
- first_name: T
full_name: Wanek, T
last_name: Wanek
- first_name: O
full_name: Langer, O
last_name: Langer
citation:
ama: Tournier N, Goutal S, Mairinger S, et al. Complete inhibition of ABCB1 and
ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to
improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. Journal
of Cerebral Blood Flow and Metabolism. 2021;41(7):1634-1646. doi:10.1177/0271678X20965500
apa: Tournier, N., Goutal, S., Mairinger, S., Lozano, I., Filip, T., Sauberer, M.,
… Langer, O. (2021). Complete inhibition of ABCB1 and ABCG2 at the blood-brain
barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of
the model ABCB1/ABCG2 substrate [11C]erlotinib. Journal of Cerebral Blood Flow
and Metabolism. SAGE Publications. https://doi.org/10.1177/0271678X20965500
chicago: Tournier, N, S Goutal, S Mairinger, IH Lozano, T Filip, M Sauberer, F Caillé,
et al. “Complete Inhibition of ABCB1 and ABCG2 at the Blood-Brain Barrier by Co-Infusion
of Erlotinib and Tariquidar to Improve Brain Delivery of the Model ABCB1/ABCG2
Substrate [11C]Erlotinib.” Journal of Cerebral Blood Flow and Metabolism.
SAGE Publications, 2021. https://doi.org/10.1177/0271678X20965500.
ieee: N. Tournier et al., “Complete inhibition of ABCB1 and ABCG2 at the
blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain
delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib,” Journal of Cerebral
Blood Flow and Metabolism, vol. 41, no. 7. SAGE Publications, pp. 1634–1646,
2021.
ista: Tournier N, Goutal S, Mairinger S, Lozano I, Filip T, Sauberer M, Caillé F,
Breuil L, Stanek J, Freeman A, Novarino G, Truillet C, Wanek T, Langer O. 2021.
Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion
of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2
substrate [11C]erlotinib. Journal of Cerebral Blood Flow and Metabolism. 41(7),
1634–1646.
mla: Tournier, N., et al. “Complete Inhibition of ABCB1 and ABCG2 at the Blood-Brain
Barrier by Co-Infusion of Erlotinib and Tariquidar to Improve Brain Delivery of
the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” Journal of Cerebral Blood
Flow and Metabolism, vol. 41, no. 7, SAGE Publications, 2021, pp. 1634–46,
doi:10.1177/0271678X20965500.
short: N. Tournier, S. Goutal, S. Mairinger, I. Lozano, T. Filip, M. Sauberer, F.
Caillé, L. Breuil, J. Stanek, A. Freeman, G. Novarino, C. Truillet, T. Wanek,
O. Langer, Journal of Cerebral Blood Flow and Metabolism 41 (2021) 1634–1646.
date_created: 2020-11-06T08:39:01Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2023-10-18T06:45:30Z
day: '01'
department:
- _id: GaNo
doi: 10.1177/0271678X20965500
external_id:
isi:
- '000664214100012'
pmid:
- '33081568'
intvolume: ' 41'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221757/
month: '07'
oa: 1
oa_version: Published Version
page: 1634-1646
pmid: 1
publication: Journal of Cerebral Blood Flow and Metabolism
publication_identifier:
eissn:
- 1559-7016
issn:
- 0271-678x
publication_status: published
publisher: SAGE Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion
of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate
[11C]erlotinib
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2021'
...
---
_id: '8742'
abstract:
- lang: eng
text: We develop a version of Ekedahl’s geometric sieve for integral quadratic forms
of rank at least five. As one ranges over the zeros of such quadratic forms, we
use the sieve to compute the density of coprime values of polynomials, and furthermore,
to address a question about local solubility in families of varieties parameterised
by the zeros.
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Timothy D
full_name: Browning, Timothy D
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Roger
full_name: Heath-Brown, Roger
last_name: Heath-Brown
citation:
ama: Browning TD, Heath-Brown R. The geometric sieve for quadrics. Forum Mathematicum.
2021;33(1):147-165. doi:10.1515/forum-2020-0074
apa: Browning, T. D., & Heath-Brown, R. (2021). The geometric sieve for quadrics.
Forum Mathematicum. De Gruyter. https://doi.org/10.1515/forum-2020-0074
chicago: Browning, Timothy D, and Roger Heath-Brown. “The Geometric Sieve for Quadrics.”
Forum Mathematicum. De Gruyter, 2021. https://doi.org/10.1515/forum-2020-0074.
ieee: T. D. Browning and R. Heath-Brown, “The geometric sieve for quadrics,” Forum
Mathematicum, vol. 33, no. 1. De Gruyter, pp. 147–165, 2021.
ista: Browning TD, Heath-Brown R. 2021. The geometric sieve for quadrics. Forum
Mathematicum. 33(1), 147–165.
mla: Browning, Timothy D., and Roger Heath-Brown. “The Geometric Sieve for Quadrics.”
Forum Mathematicum, vol. 33, no. 1, De Gruyter, 2021, pp. 147–65, doi:10.1515/forum-2020-0074.
short: T.D. Browning, R. Heath-Brown, Forum Mathematicum 33 (2021) 147–165.
date_created: 2020-11-08T23:01:25Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-10-17T07:39:01Z
day: '01'
department:
- _id: TiBr
doi: 10.1515/forum-2020-0074
external_id:
arxiv:
- '2003.09593'
isi:
- '000604750900008'
intvolume: ' 33'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2003.09593
month: '01'
oa: 1
oa_version: Preprint
page: 147-165
project:
- _id: 26AEDAB2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P32428
name: New frontiers of the Manin conjecture
publication: Forum Mathematicum
publication_identifier:
eissn:
- 1435-5337
issn:
- 0933-7741
publication_status: published
publisher: De Gruyter
quality_controlled: '1'
scopus_import: '1'
status: public
title: The geometric sieve for quadrics
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2021'
...
---
_id: '8743'
abstract:
- lang: eng
text: 'Montane cloud forests are areas of high endemism, and are one of the more
vulnerable terrestrial ecosystems to climate change. Thus, understanding how they
both contribute to the generation of biodiversity, and will respond to ongoing
climate change, are important and related challenges. The widely accepted model
for montane cloud forest dynamics involves upslope forcing of their range limits
with global climate warming. However, limited climate data provides some support
for an alternative model, where range limits are forced downslope with climate
warming. Testing between these two models is challenging, due to the inherent
limitations of climate and pollen records. We overcome this with an alternative
source of historical information, testing between competing model predictions
using genomic data and demographic analyses for a species of beetle tightly associated
to an oceanic island cloud forest. Results unequivocally support the alternative
model: populations that were isolated at higher elevation peaks during the Last
Glacial Maximum are now in contact and hybridizing at lower elevations. Our results
suggest that genomic data are a rich source of information to further understand
how montane cloud forest biodiversity originates, and how it is likely to be impacted
by ongoing climate change.'
acknowledgement: 'This work was financed by the Spanish Agencia Estatal de Investigación
(CGL2017‐85718‐P), awarded to BCE, and co‐financed by FEDER. It was also supported
by the Spanish Ministerio de Ciencia, Innovación y Universidades (EQC2018‐004418‐P),
awarded to BCE. AS‐C was funded by the Spanish Ministerio de Ciencia, Innovación
y Universidades through an FPU PhD fellowship (FPU014/02948). The authors thank
Instituto Tecnológico y de Energías Renovables (ITER), S.A for providing access
to the Teide High‐Performance Computing facility (Teide‐HPC). Fieldwork was supported
by collecting permit AFF 107/17 (sigma number 2017‐00572) kindly provided by the
Cabildo of Tenerife. The authors wish to thank the following for field work and
sample sorting and identification: A. J. Pérez‐Delgado, H. López, and C. Andújar.
We also thank V. García‐Olivares for assistance with laboratory and bioinformatic
work.'
article_processing_charge: No
article_type: original
author:
- first_name: Antonia
full_name: Salces-Castellano, Antonia
last_name: Salces-Castellano
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Paula
full_name: Arribas, Paula
last_name: Arribas
- first_name: Jairo
full_name: Patino, Jairo
last_name: Patino
- first_name: 'Dirk N. '
full_name: 'Karger, Dirk N. '
last_name: Karger
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
- first_name: Brent C.
full_name: Emerson, Brent C.
last_name: Emerson
citation:
ama: Salces-Castellano A, Stankowski S, Arribas P, et al. Long-term cloud forest
response to climate warming revealed by insect speciation history. Evolution.
2021;75(2):231-244. doi:10.1111/evo.14111
apa: Salces-Castellano, A., Stankowski, S., Arribas, P., Patino, J., Karger, D.
N., Butlin, R., & Emerson, B. C. (2021). Long-term cloud forest response to
climate warming revealed by insect speciation history. Evolution. Wiley.
https://doi.org/10.1111/evo.14111
chicago: Salces-Castellano, Antonia, Sean Stankowski, Paula Arribas, Jairo Patino,
Dirk N. Karger, Roger Butlin, and Brent C. Emerson. “Long-Term Cloud Forest Response
to Climate Warming Revealed by Insect Speciation History.” Evolution. Wiley,
2021. https://doi.org/10.1111/evo.14111.
ieee: A. Salces-Castellano et al., “Long-term cloud forest response to climate
warming revealed by insect speciation history,” Evolution, vol. 75, no.
2. Wiley, pp. 231–244, 2021.
ista: Salces-Castellano A, Stankowski S, Arribas P, Patino J, Karger DN, Butlin
R, Emerson BC. 2021. Long-term cloud forest response to climate warming revealed
by insect speciation history. Evolution. 75(2), 231–244.
mla: Salces-Castellano, Antonia, et al. “Long-Term Cloud Forest Response to Climate
Warming Revealed by Insect Speciation History.” Evolution, vol. 75, no.
2, Wiley, 2021, pp. 231–44, doi:10.1111/evo.14111.
short: A. Salces-Castellano, S. Stankowski, P. Arribas, J. Patino, D.N. Karger,
R. Butlin, B.C. Emerson, Evolution 75 (2021) 231–244.
date_created: 2020-11-08T23:01:26Z
date_published: 2021-02-01T00:00:00Z
date_updated: 2023-08-04T11:09:49Z
day: '01'
department:
- _id: NiBa
doi: 10.1111/evo.14111
external_id:
isi:
- '000583190600001'
pmid:
- '33078844'
intvolume: ' 75'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://hdl.handle.net/10261/223937
month: '02'
oa: 1
oa_version: Submitted Version
page: 231-244
pmid: 1
publication: Evolution
publication_identifier:
eissn:
- 1558-5646
issn:
- 0014-3820
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1111/evo.14225
scopus_import: '1'
status: public
title: Long-term cloud forest response to climate warming revealed by insect speciation
history
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 75
year: '2021'
...
---
_id: '8757'
abstract:
- lang: eng
text: Traditional scientific conferences and seminar events have been hugely disrupted
by the COVID-19 pandemic, paving the way for virtual forms of scientific communication
to take hold and be put to the test.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Panagiotis
full_name: Bozelos, Panagiotis
id: 52e9c652-2982-11eb-81d4-b43d94c63700
last_name: Bozelos
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
citation:
ama: Bozelos P, Vogels TP. Talking science, online. Nature Reviews Neuroscience.
2021;22(1):1-2. doi:10.1038/s41583-020-00408-6
apa: Bozelos, P., & Vogels, T. P. (2021). Talking science, online. Nature
Reviews Neuroscience. Springer Nature. https://doi.org/10.1038/s41583-020-00408-6
chicago: Bozelos, Panagiotis, and Tim P Vogels. “Talking Science, Online.” Nature
Reviews Neuroscience. Springer Nature, 2021. https://doi.org/10.1038/s41583-020-00408-6.
ieee: P. Bozelos and T. P. Vogels, “Talking science, online,” Nature Reviews
Neuroscience, vol. 22, no. 1. Springer Nature, pp. 1–2, 2021.
ista: Bozelos P, Vogels TP. 2021. Talking science, online. Nature Reviews Neuroscience.
22(1), 1–2.
mla: Bozelos, Panagiotis, and Tim P. Vogels. “Talking Science, Online.” Nature
Reviews Neuroscience, vol. 22, no. 1, Springer Nature, 2021, pp. 1–2, doi:10.1038/s41583-020-00408-6.
short: P. Bozelos, T.P. Vogels, Nature Reviews Neuroscience 22 (2021) 1–2.
date_created: 2020-11-15T23:01:18Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-08-04T11:10:20Z
day: '01'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1038/s41583-020-00408-6
external_id:
isi:
- '000588256300001'
pmid:
- '33173190'
file:
- access_level: open_access
checksum: 7985d7dff94c086e35b94a911d78d9ad
content_type: application/pdf
creator: dernst
date_created: 2021-02-04T10:34:22Z
date_updated: 2021-02-04T10:34:22Z
file_id: '9088'
file_name: 2021_NatureNeuroScience_Bozelos.pdf
file_size: 683634
relation: main_file
success: 1
file_date_updated: 2021-02-04T10:34:22Z
has_accepted_license: '1'
intvolume: ' 22'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 1-2
pmid: 1
publication: Nature Reviews Neuroscience
publication_identifier:
eissn:
- '14710048'
issn:
- 1471003X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Talking science, online
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 22
year: '2021'
...
---
_id: '8773'
abstract:
- lang: eng
text: Let g be a complex semisimple Lie algebra. We give a classification of contravariant
forms on the nondegenerate Whittaker g-modules Y(χ,η) introduced by Kostant. We
prove that the set of all contravariant forms on Y(χ,η) forms a vector space whose
dimension is given by the cardinality of the Weyl group of g. We also describe
a procedure for parabolically inducing contravariant forms. As a corollary, we
deduce the existence of the Shapovalov form on a Verma module, and provide a formula
for the dimension of the space of contravariant forms on the degenerate Whittaker
modules M(χ,η) introduced by McDowell.
acknowledgement: "We would like to thank Peter Trapa for useful discussions, and Dragan
Milicic and Arun Ram for valuable feedback on the structure of the paper. The first
author acknowledges the support of the European Unions Horizon 2020 research and
innovation programme under the Marie Skodowska-Curie Grant Agreement No. 754411.
The second author is\r\nsupported by the National Science Foundation Award No. 1803059."
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Adam
full_name: Brown, Adam
id: 70B7FDF6-608D-11E9-9333-8535E6697425
last_name: Brown
- first_name: Anna
full_name: Romanov, Anna
last_name: Romanov
citation:
ama: Brown A, Romanov A. Contravariant forms on Whittaker modules. Proceedings
of the American Mathematical Society. 2021;149(1):37-52. doi:10.1090/proc/15205
apa: Brown, A., & Romanov, A. (2021). Contravariant forms on Whittaker modules.
Proceedings of the American Mathematical Society. American Mathematical
Society. https://doi.org/10.1090/proc/15205
chicago: Brown, Adam, and Anna Romanov. “Contravariant Forms on Whittaker Modules.”
Proceedings of the American Mathematical Society. American Mathematical
Society, 2021. https://doi.org/10.1090/proc/15205.
ieee: A. Brown and A. Romanov, “Contravariant forms on Whittaker modules,” Proceedings
of the American Mathematical Society, vol. 149, no. 1. American Mathematical
Society, pp. 37–52, 2021.
ista: Brown A, Romanov A. 2021. Contravariant forms on Whittaker modules. Proceedings
of the American Mathematical Society. 149(1), 37–52.
mla: Brown, Adam, and Anna Romanov. “Contravariant Forms on Whittaker Modules.”
Proceedings of the American Mathematical Society, vol. 149, no. 1, American
Mathematical Society, 2021, pp. 37–52, doi:10.1090/proc/15205.
short: A. Brown, A. Romanov, Proceedings of the American Mathematical Society 149
(2021) 37–52.
date_created: 2020-11-19T10:17:40Z
date_published: 2021-01-01T00:00:00Z
date_updated: 2023-08-04T11:11:47Z
day: '01'
department:
- _id: HeEd
doi: 10.1090/proc/15205
ec_funded: 1
external_id:
arxiv:
- '1910.08286'
isi:
- '000600416300004'
intvolume: ' 149'
isi: 1
issue: '1'
keyword:
- Applied Mathematics
- General Mathematics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1910.08286
month: '01'
oa: 1
oa_version: Preprint
page: 37-52
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Proceedings of the American Mathematical Society
publication_identifier:
eissn:
- 1088-6826
issn:
- 0002-9939
publication_status: published
publisher: American Mathematical Society
quality_controlled: '1'
status: public
title: Contravariant forms on Whittaker modules
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 149
year: '2021'
...