[{"scopus_import":"1","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125484/"}],"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"Wiley-Blackwell","date_updated":"2023-05-16T12:07:45Z","publist_id":"3721","date_published":"2001-06-01T00:00:00Z","month":"06","article_type":"original","author":[{"last_name":"Molendijk","first_name":"Arthur","full_name":"Molendijk, Arthur"},{"first_name":"Friedrich","last_name":"Bischoff","full_name":"Bischoff, Friedrich"},{"full_name":"Rajendrakumar, Chadalavada","first_name":"Chadalavada","last_name":"Rajendrakumar"},{"full_name":"Friml, Jirí","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Braun","first_name":"Markus","full_name":"Braun, Markus"},{"last_name":"Gilroy","first_name":"Simon","full_name":"Gilroy, Simon"},{"full_name":"Palme, Klaus","first_name":"Klaus","last_name":"Palme"}],"oa_version":"Published Version","date_created":"2018-12-11T12:00:40Z","article_processing_charge":"No","_id":"2981","type":"journal_article","issue":"11","publication":"EMBO Journal","volume":20,"title":"Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth","status":"public","day":"01","page":"2779 - 2788","external_id":{"pmid":["11387211"]},"oa":1,"abstract":[{"text":"Plants contain a novel unique subfamily of Rho GTPases, vital components of cellular signalling networks. Here we report a general role for some members of this family in polarized plant growth processes. We show that Arabidopsis AtRop4 and AtRop6 encode functional GTPases with similar intrinsic GTP hydrolysis rates. We localized AtRop proteins in root meristem cells to the cross-wall and cell plate membranes. Polar localization of AtRops in trichoblasts specifies the growth sites for emerging root hairs. These sites were visible before budding and elongation of the Arabidopsis root hair when AtRops accumulated at their tips. Expression of constitutively active AtRop4 and AtRop6 mutant proteins in root hairs of transgenic Arabidopsis plants abolished polarized growth and delocalized the tip-focused Ca2+ gradient. Polar localization of AtRops was inhibited by brefeldin A, but not by other drugs such as latrunculin B, cytochalasin D or caffeine. Our results demonstrate a general function of AtRop GTPases in tip growth and in polar diffuse growth.","lang":"eng"}],"acknowledgement":"We thank Drs Frantisek Baluška, Matthias Godde, Peter Huijser, Lars Vahlkamp and Dieter Volkmann for help, criticism and constructive reading of the manuscript. We are grateful to Dr N.-H.Chua for providing us with pTA7002. The work was funded by the DFG, the European Communities Biotechnology Programme (Bio4-CT98 0239) and the INCO Copernicus Programme (IC15-CT96-0920). C.S.V.R. is the recipient of an Alexander von Humboldt fellowship and J.F. of a DAAD fellowship.","citation":{"ama":"Molendijk A, Bischoff F, Rajendrakumar C, et al. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. EMBO Journal. 2001;20(11):2779-2788. doi:10.1093/emboj/20.11.2779","short":"A. Molendijk, F. Bischoff, C. Rajendrakumar, J. Friml, M. Braun, S. Gilroy, K. Palme, EMBO Journal 20 (2001) 2779–2788.","chicago":"Molendijk, Arthur, Friedrich Bischoff, Chadalavada Rajendrakumar, Jiří Friml, Markus Braun, Simon Gilroy, and Klaus Palme. “Arabidopsis Thaliana Rop GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” EMBO Journal. Wiley-Blackwell, 2001. https://doi.org/10.1093/emboj/20.11.2779.","apa":"Molendijk, A., Bischoff, F., Rajendrakumar, C., Friml, J., Braun, M., Gilroy, S., & Palme, K. (2001). Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. EMBO Journal. Wiley-Blackwell. https://doi.org/10.1093/emboj/20.11.2779","mla":"Molendijk, Arthur, et al. “Arabidopsis Thaliana Rop GTPases Are Localized to Tips of Root Hairs and Control Polar Growth.” EMBO Journal, vol. 20, no. 11, Wiley-Blackwell, 2001, pp. 2779–88, doi:10.1093/emboj/20.11.2779.","ieee":"A. Molendijk et al., “Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth,” EMBO Journal, vol. 20, no. 11. Wiley-Blackwell, pp. 2779–2788, 2001.","ista":"Molendijk A, Bischoff F, Rajendrakumar C, Friml J, Braun M, Gilroy S, Palme K. 2001. Arabidopsis thaliana Rop GTPases are localized to tips of root hairs and control polar growth. EMBO Journal. 20(11), 2779–2788."},"doi":"10.1093/emboj/20.11.2779","quality_controlled":"1","extern":"1","pmid":1,"intvolume":" 20","year":"2001","publication_identifier":{"issn":["0261-4189"]},"language":[{"iso":"eng"}]},{"pmid":1,"intvolume":" 15","year":"2001","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0890-9369"]},"acknowledgement":"We thank Kim Hanson and Melissa McCarthy for technical support, and Adan Colon-Carmona, Jianming Li, and Karin Schumacher for their help in generating and identifying the doc1-3 T-DNA line. Seeds of ap3-1 and a cosmid library were supplied by the ABRC stock center. Jennifer Nemhauser made useful comments concerning this manuscript. This work was supported by grants from the Department of Energy (DE-FG03-89ER13993) and the National Science Foundation (MCB96-31390) to J.C., by grants from the Department of Energy (DE-FG02-98ER20313) and the National Institutes of Health (GM43644) to M.E., by a grant from DAAD to J.F., by a grant from DFG to K.P., and by a Marsden grant of New Zealand to J.P. and K.S. J.C. is an Associate Investigator of the Howard Hughes Medical Institute (HHMI), and Y.Z. is a HHMI fellow of the Life Sciences Research Foundation.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","citation":{"ama":"Gil P, Dewey E, Friml J, et al. BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. Genes and Development. 2001;15(15):1985-1997. doi:10.1101/gad.905201","mla":"Gil, Pedro, et al. “BIG: A Calossin-like Protein Required for Polar Auxin Transport in Arabidopsis.” Genes and Development, vol. 15, no. 15, Cold Spring Harbor Laboratory Press, 2001, pp. 1985–97, doi:10.1101/gad.905201.","ista":"Gil P, Dewey E, Friml J, Zhao Y, Snowden K, Putterill J, Palme K, Estelle M, Chory J. 2001. BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. Genes and Development. 15(15), 1985–1997.","ieee":"P. Gil et al., “BIG: A calossin-like protein required for polar auxin transport in Arabidopsis,” Genes and Development, vol. 15, no. 15. Cold Spring Harbor Laboratory Press, pp. 1985–1997, 2001.","chicago":"Gil, Pedro, Elizabeth Dewey, Jiří Friml, Yunde Zhao, Kimberley Snowden, Jo Putterill, Klaus Palme, Mark Estelle, and Joanne Chory. “BIG: A Calossin-like Protein Required for Polar Auxin Transport in Arabidopsis.” Genes and Development. Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.905201.","short":"P. Gil, E. Dewey, J. Friml, Y. Zhao, K. Snowden, J. Putterill, K. Palme, M. Estelle, J. Chory, Genes and Development 15 (2001) 1985–1997.","apa":"Gil, P., Dewey, E., Friml, J., Zhao, Y., Snowden, K., Putterill, J., … Chory, J. (2001). BIG: A calossin-like protein required for polar auxin transport in Arabidopsis. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.905201"},"doi":"10.1101/gad.905201","quality_controlled":"1","extern":"1","oa":1,"abstract":[{"text":"Polar auxin transport is crucial for the regulation of auxin action and required for some light-regulated responses during plant development. We have found that two mutants of Arabidopsis - doc1, which displays altered expression of light-regulated genes, and tir3, known for its reduced auxin transport - have similar defects and define mutations in a single gene that we have renamed BIG. BIG is very similar to the Drosophila gene Calossin/Pushover, a member of a gene family also present in Caenorhabditis elegans and human genomes. The protein encoded by BIG is extraordinary in size, 560 kD, and contains several putative Zn-finger domains. Expression-profiling experiments indicate that altered expression of multiple light-regulated genes in doc1 mutants can be suppressed by elevated levels of auxin caused by overexpression of an auxin biosynthetic gene, suggesting that normal auxin distribution is required to maintain low-level expression of these genes in the dark. Double mutants of tir3 with the auxin mutants pin1, pid, and axr1 display severe defects in auxin-dependent growth of the inflorescence. Chemical inhibitors of auxin transport change the intracellular localization of the auxin efflux carrier PIN1 in doc1/tir3 mutants, supporting the idea that BIG is required for normal auxin efflux.","lang":"eng"}],"page":"1985 - 1997","external_id":{"pmid":["11485992"]},"title":"BIG: A calossin-like protein required for polar auxin transport in Arabidopsis","volume":15,"status":"public","day":"01","author":[{"first_name":"Pedro","last_name":"Gil","full_name":"Gil, Pedro"},{"last_name":"Dewey","first_name":"Elizabeth","full_name":"Dewey, Elizabeth"},{"last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jirí","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí"},{"full_name":"Zhao, Yunde","last_name":"Zhao","first_name":"Yunde"},{"full_name":"Snowden, Kimberley","first_name":"Kimberley","last_name":"Snowden"},{"first_name":"Jo","last_name":"Putterill","full_name":"Putterill, Jo"},{"full_name":"Palme, Klaus","last_name":"Palme","first_name":"Klaus"},{"first_name":"Mark","last_name":"Estelle","full_name":"Estelle, Mark"},{"full_name":"Chory, Joanne","last_name":"Chory","first_name":"Joanne"}],"date_created":"2018-12-11T12:00:41Z","oa_version":"Published Version","_id":"2982","type":"journal_article","issue":"15","article_processing_charge":"No","publication":"Genes and Development","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"Cold Spring Harbor Laboratory Press","publist_id":"3720","date_updated":"2023-05-16T11:59:47Z","date_published":"2001-08-01T00:00:00Z","month":"08","article_type":"original","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC312751/"}]},{"abstract":[{"text":"Auxins represent an important class of plant hormone that regulate plant development. Plants use specialized carrier proteins to transport the auxin indole-3-acetic acid (IAA) to target tissues. To date, efflux carrier-mediated polar auxin transport has been assumed to represent the sole mode of long distance IAA movement. Localization of the auxin permease AUX1 in the Arabidopsis root apex has revealed a novel phloem-based IAA transport pathway. AUX1, asymmetrically localized to the plasma membrane of root protophloem cells, is proposed to promote the acropetal, post-phloem movement of auxin to the root apex. MS analysis shows that IAA accumulation in aux1 mutant root apices is impaired, consistent with an AUX1 phloem unloading function. AUX1 localization to columella and lateral root cap tissues of the Arabidopsis root apex reveals that the auxin permease regulates a second IAA transport pathway. Expression studies using an auxin-regulated reporter suggest that AUX1 is necessary for root gravitropism by facilitating basipetal auxin transport to distal elongation zone tissues.","lang":"eng"}],"oa":1,"external_id":{"pmid":["11641271"]},"page":"2648 - 2653","intvolume":" 15","pmid":1,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["Genes and Development"]},"year":"2001","acknowledgement":"We thank Ben Scheres and Marcus Grebe for critically reading the manuscript, Burkhard Schulz for providing advice about the HA epitope tag, and Denis Baker for valuable discussion. This work was funded by the BBSRC and European Commission grants to the LATIN and POPWOOD research consortia.\r\n\r\nThe publication costs of this article were defrayed in part by payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC section 1734 solely to indicate this fact.","extern":"1","quality_controlled":"1","doi":"10.1101/gad.210501","citation":{"ama":"Swarup R, Friml J, Marchant A, et al. Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Genes and Development. 2001;15(20):2648-2653. doi:10.1101/gad.210501","ista":"Swarup R, Friml J, Marchant A, Ljung K, Sandberg G, Palme K, Bennett M. 2001. Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Genes and Development. 15(20), 2648–2653.","ieee":"R. Swarup et al., “Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex,” Genes and Development, vol. 15, no. 20. Cold Spring Harbor Laboratory Press, pp. 2648–2653, 2001.","mla":"Swarup, Ranjan, et al. “Localization of the Auxin Permease AUX1 Suggests Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root Apex.” Genes and Development, vol. 15, no. 20, Cold Spring Harbor Laboratory Press, 2001, pp. 2648–53, doi:10.1101/gad.210501.","apa":"Swarup, R., Friml, J., Marchant, A., Ljung, K., Sandberg, G., Palme, K., & Bennett, M. (2001). Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex. Genes and Development. Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/gad.210501","chicago":"Swarup, Ranjan, Jiří Friml, Alan Marchant, Karin Ljung, Göran Sandberg, Klaus Palme, and Malcolm Bennett. “Localization of the Auxin Permease AUX1 Suggests Two Functionally Distinct Hormone Transport Pathways Operate in the Arabidopsis Root Apex.” Genes and Development. Cold Spring Harbor Laboratory Press, 2001. https://doi.org/10.1101/gad.210501.","short":"R. Swarup, J. Friml, A. Marchant, K. Ljung, G. Sandberg, K. Palme, M. Bennett, Genes and Development 15 (2001) 2648–2653."},"publist_id":"3718","date_updated":"2023-05-16T11:37:53Z","publisher":"Cold Spring Harbor Laboratory Press","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_type":"original","date_published":"2001-10-15T00:00:00Z","month":"10","scopus_import":"1","main_file_link":[{"url":"ncbi.nlm.nih.gov/pmc/articles/PMC312818/","open_access":"1"}],"status":"public","volume":15,"title":"Localization of the auxin permease AUX1 suggests two functionally distinct hormone transport pathways operate in the Arabidopsis root apex","day":"15","author":[{"first_name":"Ranjan","last_name":"Swarup","full_name":"Swarup, Ranjan"},{"last_name":"Friml","first_name":"Jirí","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jirí"},{"full_name":"Marchant, Alan","first_name":"Alan","last_name":"Marchant"},{"full_name":"Ljung, Karin","first_name":"Karin","last_name":"Ljung"},{"first_name":"Göran","last_name":"Sandberg","full_name":"Sandberg, Göran"},{"full_name":"Palme, Klaus","last_name":"Palme","first_name":"Klaus"},{"first_name":"Malcolm","last_name":"Bennett","full_name":"Bennett, Malcolm"}],"publication":"Genes and Development","_id":"2984","article_processing_charge":"No","type":"journal_article","issue":"20","oa_version":"Published Version","date_created":"2018-12-11T12:00:41Z"},{"doi":"10.1112/S0025579300015965","citation":{"apa":"Hausel, T., Makai, E., & Szücs, A. (2000). Inscribing cubes and covering by rhombic dodecahedra via equivariant topology. Mathematika. University College London. https://doi.org/10.1112/S0025579300015965","short":"T. Hausel, E. Makai, A. Szücs, Mathematika 47 (2000) 371–397.","chicago":"Hausel, Tamás, Endre Makai, and András Szücs. “Inscribing Cubes and Covering by Rhombic Dodecahedra via Equivariant Topology.” Mathematika. University College London, 2000. https://doi.org/10.1112/S0025579300015965.","ieee":"T. Hausel, E. Makai, and A. Szücs, “Inscribing cubes and covering by rhombic dodecahedra via equivariant topology,” Mathematika, vol. 47, no. 1–2. University College London, pp. 371–397, 2000.","ista":"Hausel T, Makai E, Szücs A. 2000. Inscribing cubes and covering by rhombic dodecahedra via equivariant topology. Mathematika. 47(1–2), 371–397.","mla":"Hausel, Tamás, et al. “Inscribing Cubes and Covering by Rhombic Dodecahedra via Equivariant Topology.” Mathematika, vol. 47, no. 1–2, University College London, 2000, pp. 371–97, doi:10.1112/S0025579300015965.","ama":"Hausel T, Makai E, Szücs A. Inscribing cubes and covering by rhombic dodecahedra via equivariant topology. Mathematika. 2000;47(1-2):371-397. doi:10.1112/S0025579300015965"},"quality_controlled":"1","extern":"1","acknowledgement":"The research of the first author was partially supported by Trinity College, Cambridge, and that of all the authors by grants 23444, T-030012 and A 046/96, respectively, from the Hungarian National Foundation for Scientific Research.","year":"2000","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0025-5793"]},"arxiv":1,"intvolume":" 47","page":"371 - 397","external_id":{"arxiv":["math/9906066"]},"oa":1,"abstract":[{"text":"First, a special case of Knaster's problem is proved implying that each symmetric convex body in ℝ3 admits an inscribed cube. It is deduced from a theorem in equivariant topology, which says that there is no S4 - equivariant map from SO(3) to S2, where S4 acts on SO(3) on the right as the rotation group of the cube, and on S2 on the right as the symmetry group of the regular tetrahedron. Some generalizations are also given. Second, it is shown how the above non-existence theorem yields Makeev's conjecture in ℝ3 that each set in ℝ3 of diameter 1 can be covered by a rhombic dodecahedron, which has distance 1 between its opposite faces. This reveals an unexpected connection between inscribing cubes into symmetric bodies and covering sets by rhombic dodecahedra. Finally, a possible application of our second theorem to the Borsuk problem in ℝ3 is pointed out.","lang":"eng"}],"oa_version":"Preprint","date_created":"2018-12-11T11:52:07Z","issue":"1-2","_id":"1455","article_processing_charge":"No","type":"journal_article","publication":"Mathematika","author":[{"full_name":"Hausel, Tamas","id":"4A0666D8-F248-11E8-B48F-1D18A9856A87","first_name":"Tamas","last_name":"Hausel"},{"full_name":"Makai, Endre","last_name":"Makai","first_name":"Endre"},{"first_name":"András","last_name":"Szücs","full_name":"Szücs, András"}],"day":"01","title":"Inscribing cubes and covering by rhombic dodecahedra via equivariant topology","volume":47,"status":"public","main_file_link":[{"url":"http://arxiv.org/abs/math/9906066","open_access":"1"}],"scopus_import":"1","month":"06","date_published":"2000-06-01T00:00:00Z","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"University College London","publist_id":"5745","date_updated":"2023-05-08T08:56:46Z"},{"date_published":"2000-08-01T00:00:00Z","month":"08","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"Society for Neuroscience","publist_id":"2898","date_updated":"2023-05-03T08:18:39Z","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772523/"}],"scopus_import":"1","day":"01","title":"Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse","volume":20,"status":"public","oa_version":"Published Version","date_created":"2018-12-11T12:03:36Z","_id":"3489","issue":"15","article_processing_charge":"No","type":"journal_article","publication":"Journal of Neuroscience","author":[{"full_name":"Kraushaar, Udo","last_name":"Kraushaar","first_name":"Udo"},{"full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","last_name":"Jonas"}],"oa":1,"abstract":[{"text":"We have examined factors that determine the strength and dynamics of GABAergic synapses between interneurons [dentate gyrus basket cells (BCs)] and principal neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal slices at 34°C. Unitary IPSCs recorded from BC–GC pairs in high intracellular Cl− concentration showed a fast rise and a biexponential decay, with mean time constants of 2 and 9 msec. The mean quantal conductance change, determined directly at reduced extracellular Ca2+/Mg2+concentration ratios, was 1.7 nS. Quantal release at the BC–GC synapse occurred with short delay and was highly synchronized. Analysis of IPSC peak amplitudes and numbers of failures by multiple probability compound binomial analysis indicated that synaptic transmission at the BC–GC synapse involves three to seven release sites, each of which releases transmitter with high probability (∼0.5 in 2 mMCa2+/1 mM Mg2+). Unitary BC–GC IPSCs showed paired-pulse depression (PPD); maximal depression, measured for 10 msec intervals, was 37%, and recovery from depression occurred with a time constant of 2 sec. Paired-pulse depression was mainly presynaptic in origin but appeared to be independent of previous release. Synaptic transmission at the BC–GC synapse showed frequency-dependent depression, with half-maximal decrease at 5 Hz after a series of 1000 presynaptic action potentials. The relative stability of transmission at the BC–GC synapse is consistent with a model in which an activity-dependent gating mechanism reduces release probability and thereby prevents depletion of the releasable pool of synaptic vesicles. Thus several mechanisms converge on the generation of powerful and sustained transmission at interneuron–principal neuron synapses in hippocampal circuits.","lang":"eng"}],"page":"5594 - 5607","external_id":{"pmid":["10908596"]},"year":"2000","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0270-6474"]},"pmid":1,"intvolume":" 20","citation":{"ama":"Kraushaar U, Jonas PM. Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. 2000;20(15):5594-5607. doi:10.1523/JNEUROSCI.20-15-05594.2000","mla":"Kraushaar, Udo, and Peter M. Jonas. “Efficacy and Stability of Quantal GABA Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of Neuroscience, vol. 20, no. 15, Society for Neuroscience, 2000, pp. 5594–607, doi:10.1523/JNEUROSCI.20-15-05594.2000.","ieee":"U. Kraushaar and P. M. Jonas, “Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse,” Journal of Neuroscience, vol. 20, no. 15. Society for Neuroscience, pp. 5594–5607, 2000.","ista":"Kraushaar U, Jonas PM. 2000. Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. 20(15), 5594–5607.","short":"U. Kraushaar, P.M. Jonas, Journal of Neuroscience 20 (2000) 5594–5607.","chicago":"Kraushaar, Udo, and Peter M Jonas. “Efficacy and Stability of Quantal GABA Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000.","apa":"Kraushaar, U., & Jonas, P. M. (2000). Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000"},"doi":"10.1523/JNEUROSCI.20-15-05594.2000","quality_controlled":"1","extern":"1","acknowledgement":"This work was supported by grants from the Deutsche Forschungsgemeinschaft (SFB 505/C5) and the Human Frontiers Science Program Organization (RG0017/1998-B) to P.J. Novartis generously provided CGP55845A. We thank Drs. J. Bischofberger, F. A. Edwards, J. R. P. Geiger, M. V. Jones, M. Martina, and A. Roth for critically reading this manuscript. We also thank A. Blomenkamp for technical assistance."},{"external_id":{"pmid":["11069935"]},"page":"8290 - 8297","abstract":[{"lang":"eng","text":"Long-term depression (LTD) is a form of synaptic plasticity that can be induced either by low-frequency stimulation of presynaptic fibers or in an associative manner by asynchronous pairing of presynaptic and postsynaptic activity. We investigated the induction mechanisms of associative LTD in CA1 pyramidal neurons of the hippocampus using whole-cell patch-clamp recordings and Ca2+ imaging in acute brain slices. Asynchronous pairing of postsynaptic action potentials with EPSPs evoked with a delay of 20 msec induced a robust, long-lasting depression of the EPSP amplitude to 43%. Unlike LTD induced by low-frequency stimulation, associative LTD was resistant to the application of D-AP-5, indicating that it is independent of NMDA receptors. In contrast, associative LTD was inhibited by (S)-α-methyl-4-carboxyphenyl-glycine, indicating the involvement of metabotropic glutamate receptors. Furthermore, associative LTD is dependent on the activation of voltage-gated Ca2+ channels by postsynaptic action potentials. Both nifedipine, an L-type Ca2+ channel antagonist, and ω-conotoxin GVIA, a selective N-type channel blocker, abolished the induction of associative LTD. 8-hydroxy-2-dipropylaminotetralin (OH-DPAT), a 5-HT(1A) receptor agonist, inhibited postsynaptic Ca2+ influx through N-type Ca2+ channels, without affecting presynaptic transmitter release. OH-DPAT also inhibited the induction of associative LTD, suggesting that the involvement of N-type channels makes synaptic plasticity accessible to modulation by neurotransmitters. Thus, the modulation of N-type Ca2+ channels provides a gain control for synaptic depression in hippocampal pyramidal neurons."}],"oa":1,"extern":"1","quality_controlled":"1","citation":{"ama":"Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. 2000;20(22):8290-8297. doi:10.1523/JNEUROSCI.20-22-08290.2000","apa":"Normann, C., Peckys, D., Schulze, C., Walden, J., Jonas, P. M., & Bischofberger, J. (2000). Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000","chicago":"Normann, Claus, Diana Peckys, Christian Schulze, Jörg Walden, Peter M Jonas, and Joseph Bischofberger. “Associative Long-Term Depression in the Hippocampus Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000.","short":"C. Normann, D. Peckys, C. Schulze, J. Walden, P.M. Jonas, J. Bischofberger, Journal of Neuroscience 20 (2000) 8290–8297.","ieee":"C. Normann, D. Peckys, C. Schulze, J. Walden, P. M. Jonas, and J. Bischofberger, “Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels,” Journal of Neuroscience, vol. 20, no. 22. Society for Neuroscience, pp. 8290–8297, 2000.","ista":"Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. 2000. Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. 20(22), 8290–8297.","mla":"Normann, Claus, et al. “Associative Long-Term Depression in the Hippocampus Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience, vol. 20, no. 22, Society for Neuroscience, 2000, pp. 8290–97, doi:10.1523/JNEUROSCI.20-22-08290.2000."},"doi":"10.1523/JNEUROSCI.20-22-08290.2000","acknowledgement":"This work was supported by a grant from the Deutsche Forschungsgemeinschaft Bi 642/1–2 and University funds (J.B.) and by the Vada and Theodore Stanley Foundation (J.W.). We thank Drs. M. Bartos, J. R. P. Geiger, and M. Martina for critically reading this manuscript and A. Blomenkamp for technical assistance.","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0270-6474"]},"year":"2000","intvolume":" 20","pmid":1,"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773198/"}],"article_type":"original","month":"11","date_published":"2000-11-15T00:00:00Z","date_updated":"2023-05-03T08:02:52Z","publist_id":"2897","publisher":"Society for Neuroscience","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Journal of Neuroscience","type":"journal_article","_id":"3490","article_processing_charge":"No","issue":"22","date_created":"2018-12-11T12:03:36Z","oa_version":"Published Version","author":[{"last_name":"Normann","first_name":"Claus","full_name":"Normann, Claus"},{"full_name":"Peckys, Diana","last_name":"Peckys","first_name":"Diana"},{"first_name":"Christian","last_name":"Schulze","full_name":"Schulze, Christian"},{"first_name":"Jörg","last_name":"Walden","full_name":"Walden, Jörg"},{"full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas"},{"first_name":"Joseph","last_name":"Bischofberger","full_name":"Bischofberger, Joseph"}],"day":"15","status":"public","volume":20,"title":"Associative long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+) channels"},{"page":"981 - 987","external_id":{"pmid":["10835415"]},"abstract":[{"lang":"eng","text":"A coalescence-based maximum-likelihood method is presented that aims to (i) detect diversity-reducing events in the recent history of a population and (ii) distinguish between demographic (e.g., bottlenecks) and selective causes (selective sweep) of a recent reduction of genetic variability. The former goal is achieved by taking account of the distortion in the shape of gene genealogies generated by diversity-reducing events: gene trees tend to be more star-like than under the standard coalescent. The latter issue is addressed by comparing patterns between loci: demographic events apply to the whole genome whereas selective events affect distinct regions of the genome to a varying extent. The maximum-likelihood approach allows one to estimate the time and strength of diversity-reducing events and to choose among competing hypotheses. An application to sequence data from an African population of Drosophila melanogaster shows that the bottleneck hypothesis is unlikely and that one or several selective sweeps probably occurred in the recent history of this population."}],"oa":1,"citation":{"ama":"Galtier N, Depaulis F, Barton NH. Detecting bottlenecks and selective sweeps from DNA sequence polymorphism. Genetics. 2000;155(2):981-987. doi:10.1093/genetics/155.2.981","ista":"Galtier N, Depaulis F, Barton NH. 2000. Detecting bottlenecks and selective sweeps from DNA sequence polymorphism. Genetics. 155(2), 981–987.","ieee":"N. Galtier, F. Depaulis, and N. H. Barton, “Detecting bottlenecks and selective sweeps from DNA sequence polymorphism,” Genetics, vol. 155, no. 2. Genetics Society of America, pp. 981–987, 2000.","mla":"Galtier, Nicolas, et al. “Detecting Bottlenecks and Selective Sweeps from DNA Sequence Polymorphism.” Genetics, vol. 155, no. 2, Genetics Society of America, 2000, pp. 981–87, doi:10.1093/genetics/155.2.981.","apa":"Galtier, N., Depaulis, F., & Barton, N. H. (2000). Detecting bottlenecks and selective sweeps from DNA sequence polymorphism. Genetics. Genetics Society of America. https://doi.org/10.1093/genetics/155.2.981","chicago":"Galtier, Nicolas, Frantz Depaulis, and Nicholas H Barton. “Detecting Bottlenecks and Selective Sweeps from DNA Sequence Polymorphism.” Genetics. Genetics Society of America, 2000. https://doi.org/10.1093/genetics/155.2.981.","short":"N. Galtier, F. Depaulis, N.H. Barton, Genetics 155 (2000) 981–987."},"doi":"10.1093/genetics/155.2.981","extern":"1","year":"2000","publication_identifier":{"issn":["0016-6731"]},"language":[{"iso":"eng"}],"intvolume":" 155","pmid":1,"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1461106/","open_access":"1"}],"article_type":"original","date_published":"2000-06-01T00:00:00Z","month":"06","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-04-19T14:03:56Z","publist_id":"1822","publisher":"Genetics Society of America","oa_version":"None","date_created":"2018-12-11T12:07:57Z","publication":"Genetics","article_processing_charge":"No","_id":"4270","type":"journal_article","issue":"2","author":[{"first_name":"Nicolas","last_name":"Galtier","full_name":"Galtier, Nicolas"},{"full_name":"Depaulis, Frantz","first_name":"Frantz","last_name":"Depaulis"},{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","last_name":"Barton"}],"day":"01","title":"Detecting bottlenecks and selective sweeps from DNA sequence polymorphism","volume":155,"status":"public"},{"extern":"1","doi":"10.1098/rstb.2000.0716","citation":{"ama":"Barton NH. Genetic hitchhiking. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences. 2000;355(1403):1553-1562. doi:10.1098/rstb.2000.0716","chicago":"Barton, Nicholas H. “Genetic Hitchhiking.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Royal Society of London, 2000. https://doi.org/10.1098/rstb.2000.0716.","short":"N.H. Barton, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 355 (2000) 1553–1562.","apa":"Barton, N. H. (2000). Genetic hitchhiking. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Royal Society of London. https://doi.org/10.1098/rstb.2000.0716","mla":"Barton, Nicholas H. “Genetic Hitchhiking.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 355, no. 1403, Royal Society of London, 2000, pp. 1553–62, doi:10.1098/rstb.2000.0716.","ista":"Barton NH. 2000. Genetic hitchhiking. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 355(1403), 1553–1562.","ieee":"N. H. Barton, “Genetic hitchhiking,” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 355, no. 1403. Royal Society of London, pp. 1553–1562, 2000."},"quality_controlled":"1","acknowledgement":"I am grateful to B. Charlesworth and M.Slatkin for their helpful comments. This work was supported by the Biotechnology\r\nand Biological Sciences Research Council, the Natural Environment Research Council, and the Darwin Trust of Edinburgh.","publication_identifier":{"issn":["0962-8436"]},"language":[{"iso":"eng"}],"year":"2000","pmid":1,"intvolume":" 355","external_id":{"pmid":["11127900"]},"page":"1553 - 1562","oa":1,"abstract":[{"lang":"eng","text":"Selection on one or more genes inevitably perturbs other genes, even when those genes have no direct effect on fitness. This article reviews the theory of such genetic hitchhiking, concentrating on effects on neutral loci. Maynard Smith and Haigh introduced the classical case where the perturbation is due to a single favourable mutation. This is contrasted with the apparently distinct effects of inherited variation in fitness due to loosely linked loci. A model of fluctuating selection is analysed which bridges these alternative treatments. When alleles sweep between extreme frequencies at a rate λ, the rate of drift is increased by a factor (1 + E[1/pq]λ/(2(2λ + r))), where the recombination rate r is much smaller than the strength of selection. In spatially structured populations, the effects of any one substitution are weaker, and only cause a local increase in the frequency of a neutral allele. This increase depends primarily on the rate of recombination relative to selection (r/s), and more weakly, on the neighbourhood size, Nb = 4πρσ2. Spatial subdivision may allow local selective sweeps to occur more frequently than is indicated by the overall rate of molecular evolution. However, it seems unlikely that such sweeps can be sufficiently frequent to increase significantly the drift of neutral alleles."}],"_id":"4274","issue":"1403","article_processing_charge":"No","type":"journal_article","publication":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences","date_created":"2018-12-11T12:07:59Z","oa_version":"None","author":[{"orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"day":"29","status":"public","volume":355,"title":"Genetic hitchhiking","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1692896/"}],"scopus_import":"1","date_published":"2000-11-29T00:00:00Z","month":"11","publisher":"Royal Society of London","publist_id":"1815","date_updated":"2023-04-19T09:35:31Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published"},{"publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-05-03T13:00:35Z","publist_id":"4584","publisher":"World Scientific Publishing","abstract":[{"lang":"eng","text":"In the theoretical description of recent experiments with dilute Bose gases confined in external potentials the Gross-Pitaevskii equation plays an important role. Its status as an approximation for the quantum mechanical many-body ground state problem has recently been rigorously clarified. A summary of this work is presented here."}],"oa":1,"month":"06","date_published":"2000-06-01T00:00:00Z","page":"101 - 110","external_id":{"arxiv":["math-ph/9911026"]},"main_file_link":[{"url":"http://arxiv.org/abs/math-ph/9911026","open_access":"1"}],"title":"The ground state energy and density of interacting bosons in a trap","status":"public","arxiv":1,"year":"2000","day":"01","publication_identifier":{"isbn":["9789810242374 "]},"language":[{"iso":"eng"}],"author":[{"last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert"},{"full_name":"Lieb, Élliott","last_name":"Lieb","first_name":"Élliott"},{"full_name":"Yngvason, Jakob","last_name":"Yngvason","first_name":"Jakob"}],"conference":{"name":"ISQTS: Quantum Theory and Symmetries"},"oa_version":"None","quality_controlled":"1","date_created":"2018-12-11T11:57:06Z","citation":{"ieee":"R. Seiringer, É. Lieb, and J. Yngvason, “The ground state energy and density of interacting bosons in a trap,” in Proceedings of the International Symposium on Quantum Theory and Symmetries, 2000, pp. 101–110.","ista":"Seiringer R, Lieb É, Yngvason J. 2000. The ground state energy and density of interacting bosons in a trap. Proceedings of the International Symposium on Quantum Theory and Symmetries. ISQTS: Quantum Theory and Symmetries, 101–110.","mla":"Seiringer, Robert, et al. “The Ground State Energy and Density of Interacting Bosons in a Trap.” Proceedings of the International Symposium on Quantum Theory and Symmetries, World Scientific Publishing, 2000, pp. 101–10.","apa":"Seiringer, R., Lieb, É., & Yngvason, J. (2000). The ground state energy and density of interacting bosons in a trap. In Proceedings of the International Symposium on Quantum Theory and Symmetries (pp. 101–110). World Scientific Publishing.","short":"R. Seiringer, É. Lieb, J. Yngvason, in:, Proceedings of the International Symposium on Quantum Theory and Symmetries, World Scientific Publishing, 2000, pp. 101–110.","chicago":"Seiringer, Robert, Élliott Lieb, and Jakob Yngvason. “The Ground State Energy and Density of Interacting Bosons in a Trap.” In Proceedings of the International Symposium on Quantum Theory and Symmetries, 101–10. World Scientific Publishing, 2000.","ama":"Seiringer R, Lieb É, Yngvason J. The ground state energy and density of interacting bosons in a trap. In: Proceedings of the International Symposium on Quantum Theory and Symmetries. World Scientific Publishing; 2000:101-110."},"extern":"1","publication":"Proceedings of the International Symposium on Quantum Theory and Symmetries","type":"conference","_id":"2342","article_processing_charge":"No"},{"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/0011031"}],"page":"213 - 226","date_published":"2000-11-01T00:00:00Z","month":"11","oa":1,"abstract":[{"text":"We study the energy levels of a single particle in a homogeneous magnetic field and in an axially symmetric external potential. For potentials that are superharmonic off the central axis, we find a general 'pseudoconcave' ordering of the ground state energies of the Hamiltonian restricted to the sectors with fixed angular momentum. The physical applications include atoms and ions in strong magnetic fields. There the energies are monotone increasing and concave in angular momentum. In the case of a periodic chain of atoms, the pseudoconcavity extends to the entire lowest band of Bloch functions.","lang":"eng"}],"publisher":"Springer","date_updated":"2021-01-12T06:56:54Z","publist_id":"4582","publication_status":"published","issue":"3","_id":"2343","type":"journal_article","extern":1,"publication":"Letters in Mathematical Physics","doi":" 10.1023/A:1010978807635","citation":{"apa":"Baumgartner, B., & Seiringer, R. (2000). On the ordering of energy levels in homogeneous magnetic fields. Letters in Mathematical Physics. Springer. https://doi.org/ 10.1023/A:1010978807635","chicago":"Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels in Homogeneous Magnetic Fields.” Letters in Mathematical Physics. Springer, 2000. https://doi.org/ 10.1023/A:1010978807635.","short":"B. Baumgartner, R. Seiringer, Letters in Mathematical Physics 54 (2000) 213–226.","ista":"Baumgartner B, Seiringer R. 2000. On the ordering of energy levels in homogeneous magnetic fields. Letters in Mathematical Physics. 54(3), 213–226.","ieee":"B. Baumgartner and R. Seiringer, “On the ordering of energy levels in homogeneous magnetic fields,” Letters in Mathematical Physics, vol. 54, no. 3. Springer, pp. 213–226, 2000.","mla":"Baumgartner, Bernhard, and Robert Seiringer. “On the Ordering of Energy Levels in Homogeneous Magnetic Fields.” Letters in Mathematical Physics, vol. 54, no. 3, Springer, 2000, pp. 213–26, doi: 10.1023/A:1010978807635.","ama":"Baumgartner B, Seiringer R. On the ordering of energy levels in homogeneous magnetic fields. Letters in Mathematical Physics. 2000;54(3):213-226. doi: 10.1023/A:1010978807635"},"date_created":"2018-12-11T11:57:06Z","quality_controlled":0,"author":[{"full_name":"Baumgartner, Bernhard","last_name":"Baumgartner","first_name":"Bernhard"},{"last_name":"Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","full_name":"Robert Seiringer","orcid":"0000-0002-6781-0521"}],"day":"01","year":"2000","intvolume":" 54","status":"public","volume":54,"title":"On the ordering of energy levels in homogeneous magnetic fields"},{"day":"01","status":"public","volume":61,"title":"Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional","_id":"2344","issue":"4","type":"journal_article","article_processing_charge":"No","publication":"Physical Review A - Atomic, Molecular, and Optical Physics","oa_version":"Published Version","date_created":"2018-12-11T11:57:07Z","author":[{"first_name":"Élliott","last_name":"Lieb","full_name":"Lieb, Élliott"},{"last_name":"Seiringer","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert"},{"full_name":"Yngvason, Jakob","last_name":"Yngvason","first_name":"Jakob"}],"month":"04","date_published":"2000-04-01T00:00:00Z","article_type":"original","publisher":"American Physical Society","date_updated":"2023-05-03T12:47:08Z","publist_id":"4583","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/math-ph/9908027"}],"scopus_import":"1","publication_identifier":{"issn":["0556-2791"]},"language":[{"iso":"eng"}],"year":"2000","intvolume":" 61","arxiv":1,"extern":"1","doi":"10.1103/PhysRevA.61.043602","citation":{"ama":"Lieb É, Seiringer R, Yngvason J. Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular, and Optical Physics. 2000;61(4):436021-4360213. doi:10.1103/PhysRevA.61.043602","apa":"Lieb, É., Seiringer, R., & Yngvason, J. (2000). Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular, and Optical Physics. American Physical Society. https://doi.org/10.1103/PhysRevA.61.043602","chicago":"Lieb, Élliott, Robert Seiringer, and Jakob Yngvason. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” Physical Review A - Atomic, Molecular, and Optical Physics. American Physical Society, 2000. https://doi.org/10.1103/PhysRevA.61.043602.","short":"É. Lieb, R. Seiringer, J. Yngvason, Physical Review A - Atomic, Molecular, and Optical Physics 61 (2000) 436021–4360213.","ista":"Lieb É, Seiringer R, Yngvason J. 2000. Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional. Physical Review A - Atomic, Molecular, and Optical Physics. 61(4), 436021–4360213.","ieee":"É. Lieb, R. Seiringer, and J. Yngvason, “Bosons in a trap: A rigorous derivation of the Gross-Pitaevskii energy functional,” Physical Review A - Atomic, Molecular, and Optical Physics, vol. 61, no. 4. American Physical Society, pp. 436021–4360213, 2000.","mla":"Lieb, Élliott, et al. “Bosons in a Trap: A Rigorous Derivation of the Gross-Pitaevskii Energy Functional.” Physical Review A - Atomic, Molecular, and Optical Physics, vol. 61, no. 4, American Physical Society, 2000, pp. 436021–4360213, doi:10.1103/PhysRevA.61.043602."},"quality_controlled":"1","oa":1,"abstract":[{"lang":"eng","text":"The ground-state properties of interacting Bose gases in external potentials, as considered in recent experiments, are usually described by means of the Gross-Pitaevskii energy functional. We present here a rigorous proof of the asymptotic exactness of this approximation for the ground-state energy and particle density of a dilute Bose gas with a positive interaction."}],"external_id":{"arxiv":["math-ph/9908027"]},"page":"436021 - 4360213"},{"oa":1,"abstract":[{"lang":"eng","text":"There are many types of cerebellar ataxia, including ataxia due to congenital or metabolic disorders and a paraneoplastic form in patients with gynecologic cancer, breast cancer, lung cancer, or Hodgkin's disease.1 This paraneoplastic syndrome is the only type of cerebellar ataxia associated with autoantibodies against neuronal antigens. Often, the neuronal antigens are aberrantly expressed by the tumor cells.2-4 The antineuronal autoantibodies are believed to cause cerebellar ataxia, but this is unproved.5,6 In Hodgkin's disease, the lymphoma precedes the ataxia by months to years in 80 percent of patients, and ataxia often occurs during a prolonged complete remission.4 Among patients with this type of ataxia, 30 percent have anti–Purkinje-cell antibodies, some of which have the features of the neuronal antibody anti-Tr.4,7\r\n\r\nWe identified a new autoantibody in two patients with severe cerebellar ataxia that developed while they were in remission from Hodgkin's disease. The antibody reacts specifically with the metabotropic glutamate receptor mGluR1 in mouse brain. Metabotropic glutamate receptors belong to a large family of cell-surface receptors that transmit signals into the cell by coupling to guanine nucleotide-binding proteins (G proteins) in the cytoplasm. Purified IgG from the serum of both patients blocked the glutamate-stimulated formation of inositol phosphates in Chinese-hamster-ovary (CHO) cells that expressed mGluR1α, and the injection of IgG from serum or cerebrospinal fluid into the cerebellar subarachnoid space of mice caused severe, reversible ataxia. These results indicate that antineuronal autoantibodies can cause disease of the central nervous system by blocking neuronal receptors."}],"page":"21 - 27","external_id":{"pmid":["10620645"]},"pmid":1,"intvolume":" 342","year":"2000","publication_identifier":{"issn":["0028-4793"]},"language":[{"iso":"eng"}],"acknowledgement":"Supported in part by the Ministry of Education, Science, and Culture of Japan (Dr. Nakanishi and Dr. Shigemoto); CREST of Japan Science and Technology Corporation (Dr. Shigemoto); the Life Sciences Foundation (Dr. De Zeeuw); NWO (Dr. De Zeeuw and Dr. De Leeuw); and the Human Frontier Science Program (Dr. De Zeeuw and Dr. Shigemoto).\r\nDrs. Sillevis Smitt and Kinoshita contributed equally to the article. We are indebted to A. Aiba for providing mGluR1-deficient mice; to T. Maruyama for providing human mGluR1-expressing CHO cells; to H. Jingami for helpful discussion; to A. Uesugi for photographic assistance; to M. van den Bent and C. Gaillard for clinical information on the patients; and to J. van der Burg, S.K.E. Koekkoek, K.J. Reus, and C. Vermeer for technical assistance.","doi":"10.1056/NEJM200001063420104","citation":{"ieee":"P. Sillevis Smitt et al., “Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor,” New England Journal of Medicine, vol. 342, no. 1. Massachussetts Medical Society, pp. 21–27, 2000.","ista":"Sillevis Smitt P, Kinoshita A, De Leeuw B, Moll W, Coesmans M, Jaarsma D, Henzen Logmans S, Vecht C, De Zeeuw C, Sekiyama N, Nakanishi S, Shigemoto R. 2000. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. 342(1), 21–27.","mla":"Sillevis Smitt, Peter, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor.” New England Journal of Medicine, vol. 342, no. 1, Massachussetts Medical Society, 2000, pp. 21–27, doi:10.1056/NEJM200001063420104.","apa":"Sillevis Smitt, P., Kinoshita, A., De Leeuw, B., Moll, W., Coesmans, M., Jaarsma, D., … Shigemoto, R. (2000). Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. Massachussetts Medical Society. https://doi.org/10.1056/NEJM200001063420104","chicago":"Sillevis Smitt, Peter, Ayae Kinoshita, Bertie De Leeuw, Wiebe Moll, Michiel Coesmans, Dick Jaarsma, Sonja Henzen Logmans, et al. “Paraneoplastic Cerebellar Ataxia Due to Autoantibodies against a Glutamate Receptor.” New England Journal of Medicine. Massachussetts Medical Society, 2000. https://doi.org/10.1056/NEJM200001063420104.","short":"P. Sillevis Smitt, A. Kinoshita, B. De Leeuw, W. Moll, M. Coesmans, D. Jaarsma, S. Henzen Logmans, C. Vecht, C. De Zeeuw, N. Sekiyama, S. Nakanishi, R. Shigemoto, New England Journal of Medicine 342 (2000) 21–27.","ama":"Sillevis Smitt P, Kinoshita A, De Leeuw B, et al. Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. New England Journal of Medicine. 2000;342(1):21-27. doi:10.1056/NEJM200001063420104"},"quality_controlled":"1","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"Massachussetts Medical Society","date_updated":"2023-05-03T11:14:19Z","publist_id":"4300","month":"01","date_published":"2000-01-06T00:00:00Z","article_type":"original","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://www.nejm.org/doi/full/10.1056/nejm200001063420104"}],"volume":342,"title":"Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor","status":"public","day":"06","author":[{"full_name":"Sillevis Smitt, Peter","first_name":"Peter","last_name":"Sillevis Smitt"},{"full_name":"Kinoshita, Ayae","last_name":"Kinoshita","first_name":"Ayae"},{"full_name":"De Leeuw, Bertie","first_name":"Bertie","last_name":"De Leeuw"},{"last_name":"Moll","first_name":"Wiebe","full_name":"Moll, Wiebe"},{"full_name":"Coesmans, Michiel","first_name":"Michiel","last_name":"Coesmans"},{"full_name":"Jaarsma, Dick","last_name":"Jaarsma","first_name":"Dick"},{"full_name":"Henzen Logmans, Sonja","first_name":"Sonja","last_name":"Henzen Logmans"},{"full_name":"Vecht, Charles","first_name":"Charles","last_name":"Vecht"},{"first_name":"Chris","last_name":"De Zeeuw","full_name":"De Zeeuw, Chris"},{"full_name":"Sekiyama, Naotaka","first_name":"Naotaka","last_name":"Sekiyama"},{"full_name":"Nakanishi, Shigetada","first_name":"Shigetada","last_name":"Nakanishi"},{"last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"}],"oa_version":"None","date_created":"2018-12-11T11:58:35Z","_id":"2598","issue":"1","type":"journal_article","article_processing_charge":"No","publication":"New England Journal of Medicine"},{"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772734/"}],"scopus_import":"1","article_type":"original","date_published":"2000-11-01T00:00:00Z","month":"11","publist_id":"4296","date_updated":"2023-05-03T09:48:17Z","publisher":"Society for Neuroscience","publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication":"Journal of Neuroscience","_id":"2602","issue":"21","type":"journal_article","article_processing_charge":"No","date_created":"2018-12-11T11:58:37Z","oa_version":"Published Version","author":[{"last_name":"Perroy","first_name":"Julie","full_name":"Perroy, Julie"},{"full_name":"Prezèau, Laurent","first_name":"Laurent","last_name":"Prezèau"},{"full_name":"De Waard, Michel","first_name":"Michel","last_name":"De Waard"},{"full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto"},{"last_name":"Bockaërt","first_name":"Joël","full_name":"Bockaërt, Joël"},{"full_name":"Fagni, Laurent","first_name":"Laurent","last_name":"Fagni"}],"day":"01","status":"public","title":"Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons","volume":20,"external_id":{"pmid":["11050109"]},"page":"7896 - 7904","abstract":[{"text":"Although presynaptic localization of mGluR7 is well established, the mechanism by which the receptor may control Ca2+ channels in neurons is still unknown. We show here that cultured cerebellar granule cells express native metabotropic glutamate receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was also expressed in cell bodies. This allowed us to study the effect of the transfected receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel subunit, but was abolished by quenching βγ subunits with specific intracellular peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action of mGluR7, suggesting that both G-protein βγ and αo subunits were required to mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory action of mGluR7, suggesting that a coincident activation of PLC by the G-protein βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC) abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release was required for PKC-dependent inhibition of the Ca2+ channels. Possible control of synaptic transmission by the present mechanisms is discussed.","lang":"eng"}],"oa":1,"extern":"1","quality_controlled":"1","citation":{"short":"J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, L. Fagni, Journal of Neuroscience 20 (2000) 7896–7904.","chicago":"Perroy, Julie, Laurent Prezèau, Michel De Waard, Ryuichi Shigemoto, Joël Bockaërt, and Laurent Fagni. “Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000.","apa":"Perroy, J., Prezèau, L., De Waard, M., Shigemoto, R., Bockaërt, J., & Fagni, L. (2000). Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000","mla":"Perroy, Julie, et al. “Selective Blockade of P/Q-Type Calcium Channels by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.” Journal of Neuroscience, vol. 20, no. 21, Society for Neuroscience, 2000, pp. 7896–904, doi:10.1523/JNEUROSCI.20-21-07896.2000.","ista":"Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. 2000. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 20(21), 7896–7904.","ieee":"J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, and L. Fagni, “Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons,” Journal of Neuroscience, vol. 20, no. 21. Society for Neuroscience, pp. 7896–7904, 2000.","ama":"Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. Selective blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 2000;20(21):7896-7904. doi:10.1523/JNEUROSCI.20-21-07896.2000"},"doi":"10.1523/JNEUROSCI.20-21-07896.2000","acknowledgement":"This work was supported by Centre National de la Recherche Scientifique and grants from Association Française contre les Myopathies, Fondation pour la Recherche Médicale, Bayer (France), and Hoechst-Marrion-Roussel (FRHMR1/9702). We thank J. P. Pin and F. Ango for constructive discussion of this work. We also thank Dr. J. Saugstad (Atlanta, GA) for the rat mGluR7a cDNA, J. M. Sabatier (Marseille, France) for the synthesis of the 68 AA peptide, V. Homburger (Montpellier, France) for the anti-Gαo antibody, and B. Mouillac (Montpellier, France) for the anti-cMyc monoclonal antibody.","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0270-6474"]},"year":"2000","intvolume":" 20","pmid":1},{"oa_version":"Published Version","date_created":"2018-12-11T12:01:40Z","_id":"3149","issue":"23","type":"journal_article","article_processing_charge":"No","publication":"Journal of Biological Chemistry","author":[{"full_name":"Hwang, Jae","first_name":"Jae","last_name":"Hwang"},{"last_name":"Siekhaus","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","first_name":"Daria E","full_name":"Siekhaus, Daria E","orcid":"0000-0001-8323-8353"},{"full_name":"Fuller, Robert","last_name":"Fuller","first_name":"Robert"},{"full_name":"Taghert, Paul","last_name":"Taghert","first_name":"Paul"},{"full_name":"Lindberg, Iris","first_name":"Iris","last_name":"Lindberg"}],"day":"09","volume":275,"title":"Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion","status":"public","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0021925819833215?via%3Dihub","open_access":"1"}],"scopus_import":"1","month":"06","date_published":"2000-06-09T00:00:00Z","article_type":"original","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","publisher":"American Society for Biochemistry and Molecular Biology","publist_id":"3546","date_updated":"2023-05-03T08:47:13Z","citation":{"mla":"Hwang, Jae, et al. “Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological Chemistry, vol. 275, no. 23, American Society for Biochemistry and Molecular Biology, 2000, pp. 17886–93, doi:10.1074/jbc.M000032200 .","ieee":"J. Hwang, D. E. Siekhaus, R. Fuller, P. Taghert, and I. Lindberg, “Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion,” Journal of Biological Chemistry, vol. 275, no. 23. American Society for Biochemistry and Molecular Biology, pp. 17886–17893, 2000.","ista":"Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. 2000. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. 275(23), 17886–17893.","chicago":"Hwang, Jae, Daria E Siekhaus, Robert Fuller, Paul Taghert, and Iris Lindberg. “Interaction of Drosophila Melanogaster Prohormone Convertase 2 and 7B2: Insect Cell Specific Processing and Secretion.” Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology, 2000. https://doi.org/10.1074/jbc.M000032200 .","short":"J. Hwang, D.E. Siekhaus, R. Fuller, P. Taghert, I. Lindberg, Journal of Biological Chemistry 275 (2000) 17886–17893.","apa":"Hwang, J., Siekhaus, D. E., Fuller, R., Taghert, P., & Lindberg, I. (2000). Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M000032200 ","ama":"Hwang J, Siekhaus DE, Fuller R, Taghert P, Lindberg I. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2: Insect cell specific processing and secretion. Journal of Biological Chemistry. 2000;275(23):17886-17893. doi:10.1074/jbc.M000032200 "},"doi":"10.1074/jbc.M000032200 ","quality_controlled":"1","extern":"1","acknowledgement":"This work was supported by National Institutes of Health Grants DK49703 (to I. L.), NS21749 (to P. H. T.), and GM39697 (to R. S. F.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. 10749852. We thank members of the Lindberg laboratory and Laurent Muller for helpful comments, Bin Tu for construction of the C. elegans PC2 expression vector, and Joelle Finley for assistance with cell culture.","year":"2000","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0021-9258"]},"pmid":1,"intvolume":" 275","page":"17886 - 17893","external_id":{"pmid":["10749852"]},"oa":1,"abstract":[{"lang":"eng","text":"The prohormone convertases (PCs) are an evolutionarily ancient group of proteases required for the maturation of neuropeptide and peptide hormone precursors. In Drosophila melanogaster, the homolog of prohormone convertase 2, dPC2 (amontillado), is required for normal hatching behavior, and immunoblotting data indicate that flies express 80- and 75-kDa forms of this protein. Because mouse PC2 (mPC2) requires 7B2, a helper protein for productive maturation, we searched the fly data base for the 7B2 signature motif PPNPCP and identified an expressed sequence tag clone encoding the entire open reading frame for this protein. dPC2 and d7B2 cDNAs were subcloned into expression vectors for transfection into HEK-293 cells; mPC2 and rat 7B2 were used as controls. Although active mPC2 was detected in medium in the presence of either d7B2 or r7B2, dPC2 showed no proteolytic activity upon coexpression of either d7B2 or r7B2. Labeling experiments showed that dPC2 was synthesized but not secreted from HEK-293 cells. However, when dPC2 and either d7B2 or r7B2 were coexpressed in Drosophila S2 cells, abundant immunoreactive dPC2 was secreted into the medium, coincident with the appearance of PC2 activity. Expression and secretion of dPC2 enzyme activity thus appears to require insect cell-specific posttranslational processing events. The significant differences in the cell biology of the insect and mammalian enzymes, with 7B2 absolutely required for secretion of dPC2 and zymogen conversion occurring intracellularly in the case of dPC2 but not mPC2, support the idea that the Drosophila enzyme has specific requirements for maturation and secretion that can be met only in insect cells."}]},{"main_file_link":[{"url":"https://doi.org/10.1016/S1097-2765(00)80266-X","open_access":"1"}],"scopus_import":"1","article_type":"original","date_published":"2000-06-01T00:00:00Z","month":"06","publication_status":"published","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","date_updated":"2022-07-18T08:58:31Z","publisher":"Elsevier","oa_version":"Published Version","date_created":"2022-04-07T07:57:59Z","publication":"Molecular Cell","issue":"6","_id":"11127","article_processing_charge":"No","type":"journal_article","author":[{"orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","last_name":"HETZER"},{"first_name":"Daniel","last_name":"Bilbao-Cortés","full_name":"Bilbao-Cortés, Daniel"},{"full_name":"Walther, Tobias C","first_name":"Tobias C","last_name":"Walther"},{"first_name":"Oliver J","last_name":"Gruss","full_name":"Gruss, Oliver J"},{"first_name":"Iain W","last_name":"Mattaj","full_name":"Mattaj, Iain W"}],"day":"01","volume":5,"title":"GTP hydrolysis by Ran is required for nuclear envelope assembly","status":"public","page":"1013-1024","external_id":{"pmid":["10911995"]},"keyword":["Cell Biology","Molecular Biology"],"abstract":[{"text":"Nuclear formation in Xenopus egg extracts requires cytosol and is inhibited by GTPγS, indicating a requirement for GTPase activity. Nuclear envelope (NE) vesicle fusion is extensively inhibited by GTPγS and two mutant forms of the Ran GTPase, Q69L and T24N. Depletion of either Ran or RCC1, the exchange factor for Ran, from the assembly reaction also inhibits this step of NE formation. Ran depletion can be complemented by the addition of Ran loaded with either GTP or GDP but not with GTPγS. RCC1 depletion is only complemented by RCC1 itself or by RanGTP. Thus, generation of RanGTP by RCC1 and GTP hydrolysis by Ran are both required for the extensive membrane fusion events that lead to NE formation.","lang":"eng"}],"oa":1,"quality_controlled":"1","doi":"10.1016/s1097-2765(00)80266-x","citation":{"apa":"Hetzer, M., Bilbao-Cortés, D., Walther, T. C., Gruss, O. J., & Mattaj, I. W. (2000). GTP hydrolysis by Ran is required for nuclear envelope assembly. Molecular Cell. Elsevier. https://doi.org/10.1016/s1097-2765(00)80266-x","chicago":"Hetzer, Martin, Daniel Bilbao-Cortés, Tobias C Walther, Oliver J Gruss, and Iain W Mattaj. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly.” Molecular Cell. Elsevier, 2000. https://doi.org/10.1016/s1097-2765(00)80266-x.","short":"M. Hetzer, D. Bilbao-Cortés, T.C. Walther, O.J. Gruss, I.W. Mattaj, Molecular Cell 5 (2000) 1013–1024.","ista":"Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. 2000. GTP hydrolysis by Ran is required for nuclear envelope assembly. Molecular Cell. 5(6), 1013–1024.","ieee":"M. Hetzer, D. Bilbao-Cortés, T. C. Walther, O. J. Gruss, and I. W. Mattaj, “GTP hydrolysis by Ran is required for nuclear envelope assembly,” Molecular Cell, vol. 5, no. 6. Elsevier, pp. 1013–1024, 2000.","mla":"Hetzer, Martin, et al. “GTP Hydrolysis by Ran Is Required for Nuclear Envelope Assembly.” Molecular Cell, vol. 5, no. 6, Elsevier, 2000, pp. 1013–24, doi:10.1016/s1097-2765(00)80266-x.","ama":"Hetzer M, Bilbao-Cortés D, Walther TC, Gruss OJ, Mattaj IW. GTP hydrolysis by Ran is required for nuclear envelope assembly. Molecular Cell. 2000;5(6):1013-1024. doi:10.1016/s1097-2765(00)80266-x"},"extern":"1","year":"2000","publication_identifier":{"issn":["1097-2765"]},"language":[{"iso":"eng"}],"intvolume":" 5","pmid":1},{"publisher":"Wiley","date_updated":"2023-02-10T08:27:19Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","date_published":"2000-10-01T00:00:00Z","month":"10","article_type":"original","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0"}],"status":"public","volume":51,"title":"A comparison of techniques to find mirrored hosts on the WWW","day":"01","author":[{"full_name":"Bharat, Krishna","last_name":"Bharat","first_name":"Krishna"},{"full_name":"Broder, Andrei","last_name":"Broder","first_name":"Andrei"},{"first_name":"Jeffrey","last_name":"Dean","full_name":"Dean, Jeffrey"},{"orcid":"0000-0002-5008-6530","full_name":"Henzinger, Monika H","last_name":"Henzinger","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"}],"issue":"12","_id":"11770","article_processing_charge":"No","type":"journal_article","publication":"Journal of the American Society for Information Science","oa_version":"Published Version","date_created":"2022-08-08T12:57:37Z","oa":1,"abstract":[{"text":"We compare several algorithms for identifying mirrored hosts on the World Wide Web. The algorithms operate on the basis of URL strings and linkage data: the type of information about Web pages easily available from Web proxies and crawlers. Identification of mirrored hosts can improve Web-based information retrieval in several ways: first, by identifying mirrored hosts, search engines can avoid storing and returning duplicate documents. Second, several new information retrieval techniques for the Web make inferences based on the explicit links among hypertext documents—mirroring perturbs their graph model and degrades performance. Third, mirroring information can be used to redirect users to alternate mirror sites to compensate for various failures, and can thus improve the performance of Web browsers and proxies. We evaluated four classes of “top-down” algorithms for detecting mirrored host pairs (that is, algorithms that are based on page attributes such as URL, IP address, and hyperlinks between pages, and not on the page content) on a collection of 140 million URLs (on 230,000 hosts) and their associated connectivity information. Our best approach is one which combines five algorithms and achieved a precision of 0.57 for a recall of 0.86 considering 100,000 ranked host pairs.","lang":"eng"}],"page":"1114-1122","intvolume":" 51","publication_identifier":{"issn":["0002-8231","1097-4571"]},"language":[{"iso":"eng"}],"year":"2000","extern":"1","citation":{"ama":"Bharat K, Broder A, Dean J, Henzinger MH. A comparison of techniques to find mirrored hosts on the WWW. Journal of the American Society for Information Science. 2000;51(12):1114-1122. doi:10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0","mla":"Bharat, Krishna, et al. “A Comparison of Techniques to Find Mirrored Hosts on the WWW.” Journal of the American Society for Information Science, vol. 51, no. 12, Wiley, 2000, pp. 1114–22, doi:10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0.","ista":"Bharat K, Broder A, Dean J, Henzinger MH. 2000. A comparison of techniques to find mirrored hosts on the WWW. Journal of the American Society for Information Science. 51(12), 1114–1122.","ieee":"K. Bharat, A. Broder, J. Dean, and M. H. Henzinger, “A comparison of techniques to find mirrored hosts on the WWW,” Journal of the American Society for Information Science, vol. 51, no. 12. Wiley, pp. 1114–1122, 2000.","short":"K. Bharat, A. Broder, J. Dean, M.H. Henzinger, Journal of the American Society for Information Science 51 (2000) 1114–1122.","chicago":"Bharat, Krishna, Andrei Broder, Jeffrey Dean, and Monika H Henzinger. “A Comparison of Techniques to Find Mirrored Hosts on the WWW.” Journal of the American Society for Information Science. Wiley, 2000. https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0.","apa":"Bharat, K., Broder, A., Dean, J., & Henzinger, M. H. (2000). A comparison of techniques to find mirrored hosts on the WWW. Journal of the American Society for Information Science. Wiley. https://doi.org/10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0"},"doi":"10.1002/1097-4571(2000)9999:9999<::aid-asi1025>3.0.co;2-0","quality_controlled":"1"},{"extern":"1","doi":"10.1523/JNEUROSCI.19-16-j0001.1999","citation":{"ieee":"J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network oscillations in the hippocampal CA1 region of the behaving rat,” Journal of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.","ista":"Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network oscillations in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience. 19(16).","mla":"Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.","apa":"Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999). Fast network oscillations in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999","short":"J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience 19 (1999).","chicago":"Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.","ama":"Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience. 1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999"},"quality_controlled":"1","pmid":1,"intvolume":" 19","publication_identifier":{"issn":["0270-6474"]},"language":[{"iso":"eng"}],"year":"1999","external_id":{"pmid":["10436076"]},"oa":1,"abstract":[{"text":"This study examined intermittent, high-frequency (100-200 Hz) oscillatory patterns in the CA1 region of the hippocampus in the absence of theta activity, i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal activity was phase-locked not only to large amplitude (>7 SD from baseline) oscillatory events, which are present mainly during SPWs, but to smaller amplitude (<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple" frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz ("slow") oscillatory patterns. Fast ripple waves reversed just below the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves. These findings suggest that fast ripples emerge in the CA1 region, whereas slow (100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred to the CA1 field.","lang":"eng"}],"author":[{"first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036"},{"full_name":"Hirase, Hajima","first_name":"Hajima","last_name":"Hirase"},{"first_name":"András","last_name":"Czurkó","full_name":"Czurkó, András"},{"full_name":"Mamiya, Akira","last_name":"Mamiya","first_name":"Akira"},{"full_name":"Buzsáki, György","last_name":"Buzsáki","first_name":"György"}],"issue":"16","_id":"3444","article_processing_charge":"No","type":"journal_article","publication":"Journal of Neuroscience","oa_version":"Published Version","date_created":"2018-12-11T12:03:22Z","status":"public","title":"Fast network oscillations in the hippocampal CA1 region of the behaving rat","volume":19,"day":"15","scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/","open_access":"1"}],"publisher":"Society for Neuroscience","date_updated":"2022-09-07T13:41:18Z","publist_id":"2943","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","month":"08","date_published":"1999-08-15T00:00:00Z","article_type":"original"},{"extern":"1","citation":{"ama":"Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999","mla":"Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.","ieee":"G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society for Neuroscience, pp. 6191–6199, 1999.","ista":"Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. 19(14), 6191–6199.","short":"G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience 19 (1999) 6191–6199.","chicago":"Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.","apa":"Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999). Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999"},"doi":"10.1523/JNEUROSCI.19-14-06191.1999","quality_controlled":"1","acknowledgement":"This work was supported by National Institutes of Health Grants NS34994 and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and support and T. F. Freund for his comments on this manuscript.","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0270-6474"]},"year":"1999","pmid":1,"intvolume":" 19","external_id":{"pmid":["10407055"]},"page":"6191 - 6199","oa":1,"abstract":[{"lang":"eng","text":"The medial septal region and the hippocampus are connected reciprocally via GABAergic neurons, but the physiological role of this loop is still not well understood. In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta activity and extracellular units recorded in the medial septum and diagonal band of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%) were significantly suppressed during SPWs. Most cells inhibited during SPW (80%) fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal layer theta waves. Because both SPW and the negative peak of local theta waves correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron classes, the findings indicate that the activity of medial septal neurons can be negatively (during SPW) or positively (during theta waves) correlated with the activity of hippocampal interneurons. We hypothesize that the functional coupling between medial septal neurons and hippocampal interneurons varies in a state-dependent manner."}],"_id":"3445","type":"journal_article","issue":"14","article_processing_charge":"No","publication":"Journal of Neuroscience","date_created":"2018-12-11T12:03:22Z","oa_version":"Published Version","author":[{"full_name":"Dragoi, George","last_name":"Dragoi","first_name":"George"},{"first_name":"Daniel","last_name":"Carpi","full_name":"Carpi, Daniel"},{"full_name":"Recce, Michael","first_name":"Michael","last_name":"Recce"},{"full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Buzsáki","first_name":"György","full_name":"Buzsáki, György"}],"day":"15","status":"public","title":"Interactions between hippocampus and medial septum during sharp waves and theta oscillation in the behaving rat","volume":19,"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/","open_access":"1"}],"scopus_import":"1","date_published":"1999-07-15T00:00:00Z","month":"07","article_type":"original","publisher":"Society for Neuroscience","date_updated":"2022-09-07T13:37:41Z","publist_id":"2942","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published"},{"oa":1,"abstract":[{"text":"Information in neuronal networks may be represented by the spatiotemporal patterns of spikes. Here we examined the temporal coordination of pyramidal cell spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained to run in a defined position in space (running wheel) to activate a selected group of pyramidal cells. A template-matching method and a joint probability map method were used for sequence search. Repeating spike sequences in excess of chance occurrence were examined by comparing the number of repeating sequences in the original spike trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four different shuffling procedures were used to control for the population dynamics of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies were present in both the awake and sleeping animal in excess of what might be predicted by random variations. Spike sequences observed during wheel running were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave sleep. We hypothesize that the endogenously expressed spike sequences during sleep reflect reactivation of the circuitry modified by previous experience. Reactivation of acquired sequences may serve to consolidate information.","lang":"eng"}],"external_id":{"pmid":["10531452"]},"page":"9497 - 9507","pmid":1,"intvolume":" 19","publication_identifier":{"issn":["0270-6474"]},"language":[{"iso":"eng"}],"year":"1999","acknowledgement":"This work was supported by National Institutes of Health Grants NS34994 and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and Matthew Wilson for their suggestions with data analysis and comments on this manuscript.","extern":"1","doi":"10.1523/JNEUROSCI.19-21-09497.1999","citation":{"short":"Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience 19 (1999) 9497–9507.","chicago":"Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.","apa":"Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999). Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999","mla":"Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.","ista":"Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. 19(21), 9497–9507.","ieee":"Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay and time compression of recurring spike sequences in the hippocampus,” Journal of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507, 1999.","ama":"Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression of recurring spike sequences in the hippocampus. Journal of Neuroscience. 1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999"},"quality_controlled":"1","publisher":"Society for Neuroscience","publist_id":"2866","date_updated":"2022-09-07T12:48:08Z","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publication_status":"published","date_published":"1999-11-01T00:00:00Z","month":"11","article_type":"original","scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/","open_access":"1"}],"status":"public","volume":19,"title":"Replay and time compression of recurring spike sequences in the hippocampus","day":"01","author":[{"full_name":"Nádasdy, Zoltán","last_name":"Nádasdy","first_name":"Zoltán"},{"last_name":"Hirase","first_name":"Hajima","full_name":"Hirase, Hajima"},{"last_name":"Czurkó","first_name":"András","full_name":"Czurkó, András"},{"orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","last_name":"Csicsvari"},{"first_name":"György","last_name":"Buzsáki","full_name":"Buzsáki, György"}],"article_processing_charge":"No","_id":"3518","type":"journal_article","issue":"21","publication":"Journal of Neuroscience","oa_version":"Published Version","date_created":"2018-12-11T12:03:45Z"},{"author":[{"full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L"},{"last_name":"Hirase","first_name":"Hajima","full_name":"Hirase, Hajima"},{"full_name":"Czurkó, András","last_name":"Czurkó","first_name":"András"},{"full_name":"Mamiya, Akira","first_name":"Akira","last_name":"Mamiya"},{"last_name":"Buzsáki","first_name":"György","full_name":"Buzsáki, György"}],"date_created":"2018-12-11T12:03:47Z","oa_version":"Published Version","publication":"Journal of Neuroscience","issue":"1","_id":"3524","article_processing_charge":"No","type":"journal_article","volume":19,"title":"Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat","status":"public","day":"01","scopus_import":"1","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/","open_access":"1"}],"publication_status":"published","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2022-09-07T10:00:45Z","publist_id":"2860","publisher":"Society for Neuroscience","article_type":"original","date_published":"1999-01-01T00:00:00Z","month":"01","acknowledgement":"This work was supported by National Institutes of Health Grants NS34994, MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and Ken Wise for supplying us with silicon probes.","quality_controlled":"1","citation":{"ama":"Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999","ista":"Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. 19(1), 274–287.","ieee":"J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat,” Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp. 274–287, 1999.","mla":"Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol. 19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.","apa":"Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999). Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999","chicago":"Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999.","short":"J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience 19 (1999) 274–287."},"doi":"10.1523/JNEUROSCI.19-01-00274.1999","extern":"1","intvolume":" 19","pmid":1,"year":"1999","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0270-6474"]},"page":"274 - 287","external_id":{"pmid":["9870957"]},"abstract":[{"text":"We examined whether excitation and inhibition are balanced in hippocampal cortical networks. Extracellular field and single-unit activity were recorded by multiple tetrodes and multisite silicon probes to reveal the timing of the activity of hippocampal CAI pyramidal cells and classes of interneurons during theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and dendritic inhibition of pyramidal cells was deduced from the activity of interneurons in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively. int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population discharge of pyramidal cells during the theta cycle, respectively. SPW ripples were associated with a 2.5-fold net increase of excitation. The discharge frequency of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent” cells) during SPW suggesting that not all interneurons are innervated by pyramidal cells. Int(p) either fired together with (unimodal cells) or both before and after (bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum discharge probability of pyramidal neurons by 1-2 msec. Network state changes, as reflected by field activity, covaried with changes in the spike train dynamics of single cells and their interactions. Summed activity of parallel-recorded interneurons, but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse was true for the ripple cycles of SPWs. We suggest that network-driven excitability changes provide temporal windows of opportunity for single pyramidal cells to suppress, enable, or facilitate selective synaptic inputs.","lang":"eng"}],"oa":1}]