[{"department":[{"_id":"NiBa"},{"_id":"GaTk"}],"publisher":"American Institute of Physics","date_created":"2018-12-11T11:54:35Z","citation":{"ista":"Kollár R, Bodova K, Nosek J, Tomáška Ľ. 2014. Mathematical model of alternative mechanism of telomere length maintenance. Physical Review E Statistical Nonlinear and Soft Matter Physics. 89(3), 032701.","ama":"Kollár R, Bodova K, Nosek J, Tomáška Ľ. Mathematical model of alternative mechanism of telomere length maintenance. <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. 2014;89(3). doi:<a href=\"https://doi.org/10.1103/PhysRevE.89.032701\">10.1103/PhysRevE.89.032701</a>","ieee":"R. Kollár, K. Bodova, J. Nosek, and Ľ. Tomáška, “Mathematical model of alternative mechanism of telomere length maintenance,” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 89, no. 3. American Institute of Physics, 2014.","apa":"Kollár, R., Bodova, K., Nosek, J., &#38; Tomáška, Ľ. (2014). Mathematical model of alternative mechanism of telomere length maintenance. <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics. <a href=\"https://doi.org/10.1103/PhysRevE.89.032701\">https://doi.org/10.1103/PhysRevE.89.032701</a>","chicago":"Kollár, Richard, Katarina Bodova, Jozef Nosek, and Ľubomír Tomáška. “Mathematical Model of Alternative Mechanism of Telomere Length Maintenance.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>. American Institute of Physics, 2014. <a href=\"https://doi.org/10.1103/PhysRevE.89.032701\">https://doi.org/10.1103/PhysRevE.89.032701</a>.","mla":"Kollár, Richard, et al. “Mathematical Model of Alternative Mechanism of Telomere Length Maintenance.” <i>Physical Review E Statistical Nonlinear and Soft Matter Physics</i>, vol. 89, no. 3, 032701, American Institute of Physics, 2014, doi:<a href=\"https://doi.org/10.1103/PhysRevE.89.032701\">10.1103/PhysRevE.89.032701</a>.","short":"R. Kollár, K. Bodova, J. Nosek, Ľ. Tomáška, Physical Review E Statistical Nonlinear and Soft Matter Physics 89 (2014)."},"publication_status":"published","title":"Mathematical model of alternative mechanism of telomere length maintenance","date_published":"2014-03-04T00:00:00Z","_id":"1896","article_number":"032701","abstract":[{"text":"Biopolymer length regulation is a complex process that involves a large number of biological, chemical, and physical subprocesses acting simultaneously across multiple spatial and temporal scales. An illustrative example important for genomic stability is the length regulation of telomeres - nucleoprotein structures at the ends of linear chromosomes consisting of tandemly repeated DNA sequences and a specialized set of proteins. Maintenance of telomeres is often facilitated by the enzyme telomerase but, particularly in telomerase-free systems, the maintenance of chromosomal termini depends on alternative lengthening of telomeres (ALT) mechanisms mediated by recombination. Various linear and circular DNA structures were identified to participate in ALT, however, dynamics of the whole process is still poorly understood. We propose a chemical kinetics model of ALT with kinetic rates systematically derived from the biophysics of DNA diffusion and looping. The reaction system is reduced to a coagulation-fragmentation system by quasi-steady-state approximation. The detailed treatment of kinetic rates yields explicit formulas for expected size distributions of telomeres that demonstrate the key role played by the J factor, a quantitative measure of bending of polymers. The results are in agreement with experimental data and point out interesting phenomena: an appearance of very long telomeric circles if the total telomere density exceeds a critical value (excess mass) and a nonlinear response of the telomere size distributions to the amount of telomeric DNA in the system. The results can be of general importance for understanding dynamics of telomeres in telomerase-independent systems as this mode of telomere maintenance is similar to the situation in tumor cells lacking telomerase activity. Furthermore, due to its universality, the model may also serve as a prototype of an interaction between linear and circular DNA structures in various settings.","lang":"eng"}],"date_updated":"2022-08-01T10:50:10Z","acknowledgement":"The work was supported by the VEGA Grant No. 1/0459/13 (R.K. and K.B.).","main_file_link":[{"url":"http://arxiv.org/abs/1402.0430","open_access":"1"}],"author":[{"last_name":"Kollár","first_name":"Richard","full_name":"Kollár, Richard"},{"id":"2BA24EA0-F248-11E8-B48F-1D18A9856A87","last_name":"Bod'ová","full_name":"Bod'ová, Katarína","first_name":"Katarína","orcid":"0000-0002-7214-0171"},{"last_name":"Nosek","full_name":"Nosek, Jozef","first_name":"Jozef"},{"first_name":"Ľubomír","full_name":"Tomáška, Ľubomír","last_name":"Tomáška"}],"issue":"3","intvolume":"        89","type":"journal_article","publication":"Physical Review E Statistical Nonlinear and Soft Matter Physics","doi":"10.1103/PhysRevE.89.032701","volume":89,"oa":1,"oa_version":"Submitted Version","scopus_import":"1","day":"04","publist_id":"5198","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"03","status":"public","language":[{"iso":"eng"}],"year":"2014","article_processing_charge":"No"},{"date_updated":"2021-01-12T06:53:55Z","abstract":[{"lang":"eng","text":"GNOM is one of the most characterized membrane trafficking regulators in plants, with crucial roles in development. GNOM encodes an ARF-guanine nucleotide exchange factor (ARF-GEF) that activates small GTPases of the ARF (ADP ribosylation factor) class to mediate vesicle budding at endomembranes. The crucial role of GNOM in recycling of PIN auxin transporters and other proteins to the plasma membrane was identified in studies using the ARF-GEF inhibitor brefeldin A (BFA). GNOM, the most prominent regulator of recycling in plants, has been proposed to act and localize at so far elusive recycling endosomes. Here, we report the GNOM localization in context of its cellular function in Arabidopsis thaliana. State-of-the-art imaging, pharmacological interference, and ultrastructure analysis show that GNOM predominantly localizes to Golgi apparatus. Super-resolution confocal live imaging microscopy identified GNOM and its closest homolog GNOM-like 1 at distinct subdomains on Golgi cisternae. Short-term BFA treatment stabilizes GNOM at the Golgi apparatus, whereas prolonged exposures results in GNOM translocation to trans-Golgi network (TGN)/early endosomes (EEs). Malformed TGN/EE in gnom mutants suggests a role for GNOM in maintaining TGN/EE function. Our results redefine the subcellular action of GNOM and reevaluate the identity and function of recycling endosomes in plants."}],"page":"3062 - 3076","scopus_import":1,"issue":"7","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4145132/"}],"acknowledgement":"This work was supported by the Odysseus Program of the Research Foundation-Flanders (J.F.).","oa_version":"Submitted Version","author":[{"first_name":"Satoshi","full_name":"Naramoto, Satoshi","last_name":"Naramoto"},{"first_name":"Marisa","full_name":"Otegui, Marisa","last_name":"Otegui"},{"first_name":"Natsumaro","full_name":"Kutsuna, Natsumaro","last_name":"Kutsuna"},{"full_name":"De Rycke, Riet","first_name":"Riet","last_name":"De Rycke"},{"last_name":"Dainobu","full_name":"Dainobu, Tomoko","first_name":"Tomoko"},{"last_name":"Karampelias","full_name":"Karampelias, Michael","first_name":"Michael"},{"last_name":"Fujimoto","first_name":"Masaru","full_name":"Fujimoto, Masaru"},{"full_name":"Feraru, Elena","first_name":"Elena","last_name":"Feraru"},{"full_name":"Miki, Daisuke","first_name":"Daisuke","last_name":"Miki"},{"full_name":"Fukuda, Hiroo","first_name":"Hiroo","last_name":"Fukuda"},{"full_name":"Nakano, Akihiko","first_name":"Akihiko","last_name":"Nakano"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí","full_name":"Friml, Jirí"}],"publist_id":"5199","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","day":"01","type":"journal_article","intvolume":"        26","year":"2014","language":[{"iso":"eng"}],"status":"public","month":"07","publication":"Plant Cell","department":[{"_id":"JiFr"}],"doi":"10.1105/tpc.114.125880","publisher":"American Society of Plant Biologists","date_created":"2018-12-11T11:54:36Z","publication_status":"published","citation":{"apa":"Naramoto, S., Otegui, M., Kutsuna, N., De Rycke, R., Dainobu, T., Karampelias, M., … Friml, J. (2014). Insights into the localization and function of the membrane trafficking regulator GNOM ARF-GEF at the Golgi apparatus in Arabidopsis. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.114.125880\">https://doi.org/10.1105/tpc.114.125880</a>","ieee":"S. Naramoto <i>et al.</i>, “Insights into the localization and function of the membrane trafficking regulator GNOM ARF-GEF at the Golgi apparatus in Arabidopsis,” <i>Plant Cell</i>, vol. 26, no. 7. American Society of Plant Biologists, pp. 3062–3076, 2014.","ama":"Naramoto S, Otegui M, Kutsuna N, et al. Insights into the localization and function of the membrane trafficking regulator GNOM ARF-GEF at the Golgi apparatus in Arabidopsis. <i>Plant Cell</i>. 2014;26(7):3062-3076. doi:<a href=\"https://doi.org/10.1105/tpc.114.125880\">10.1105/tpc.114.125880</a>","short":"S. Naramoto, M. Otegui, N. Kutsuna, R. De Rycke, T. Dainobu, M. Karampelias, M. Fujimoto, E. Feraru, D. Miki, H. Fukuda, A. Nakano, J. Friml, Plant Cell 26 (2014) 3062–3076.","chicago":"Naramoto, Satoshi, Marisa Otegui, Natsumaro Kutsuna, Riet De Rycke, Tomoko Dainobu, Michael Karampelias, Masaru Fujimoto, et al. “Insights into the Localization and Function of the Membrane Trafficking Regulator GNOM ARF-GEF at the Golgi Apparatus in Arabidopsis.” <i>Plant Cell</i>. American Society of Plant Biologists, 2014. <a href=\"https://doi.org/10.1105/tpc.114.125880\">https://doi.org/10.1105/tpc.114.125880</a>.","mla":"Naramoto, Satoshi, et al. “Insights into the Localization and Function of the Membrane Trafficking Regulator GNOM ARF-GEF at the Golgi Apparatus in Arabidopsis.” <i>Plant Cell</i>, vol. 26, no. 7, American Society of Plant Biologists, 2014, pp. 3062–76, doi:<a href=\"https://doi.org/10.1105/tpc.114.125880\">10.1105/tpc.114.125880</a>.","ista":"Naramoto S, Otegui M, Kutsuna N, De Rycke R, Dainobu T, Karampelias M, Fujimoto M, Feraru E, Miki D, Fukuda H, Nakano A, Friml J. 2014. Insights into the localization and function of the membrane trafficking regulator GNOM ARF-GEF at the Golgi apparatus in Arabidopsis. Plant Cell. 26(7), 3062–3076."},"_id":"1897","date_published":"2014-07-01T00:00:00Z","title":"Insights into the localization and function of the membrane trafficking regulator GNOM ARF-GEF at the Golgi apparatus in Arabidopsis","volume":26,"oa":1},{"type":"journal_article","intvolume":"        16","date_updated":"2021-01-12T06:53:55Z","abstract":[{"lang":"eng","text":"Asymmetric cell divisions allow stem cells to balance proliferation and differentiation. During embryogenesis, murine epidermis expands rapidly from a single layer of unspecified basal layer progenitors to a stratified, differentiated epithelium. Morphogenesis involves perpendicular (asymmetric) divisions and the spindle orientation protein LGN, but little is known about how the apical localization of LGN is regulated. Here, we combine conventional genetics and lentiviral-mediated in vivo RNAi to explore the functions of the LGN-interacting proteins Par3, mInsc and Gα i3. Whereas loss of each gene alone leads to randomized division angles, combined loss of Gnai3 and mInsc causes a phenotype of mostly planar divisions, akin to loss of LGN. These findings lend experimental support for the hitherto untested model that Par3-mInsc and Gα i3 act cooperatively to polarize LGN and promote perpendicular divisions. Finally, we uncover a developmental switch between delamination-driven early stratification and spindle-orientation-dependent differentiation that occurs around E15, revealing a two-step mechanism underlying epidermal maturation."}],"article_type":"original","page":"758 - 769","issue":"8","author":[{"last_name":"Williams","full_name":"Williams, Scott","first_name":"Scott"},{"first_name":"Lyndsay","full_name":"Ratliff, Lyndsay","last_name":"Ratliff"},{"first_name":"Maria P","full_name":"Postiglione, Maria P","id":"2C67902A-F248-11E8-B48F-1D18A9856A87","last_name":"Postiglione"},{"last_name":"Knoblich","first_name":"Juergen","full_name":"Knoblich, Juergen"},{"first_name":"Elaine","full_name":"Fuchs, Elaine","last_name":"Fuchs"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4159251/"}],"citation":{"short":"S. Williams, L. Ratliff, M.P. Postiglione, J. Knoblich, E. Fuchs, Nature Cell Biology 16 (2014) 758–769.","chicago":"Williams, Scott, Lyndsay Ratliff, Maria P Postiglione, Juergen Knoblich, and Elaine Fuchs. “Par3-MInsc and Gα I3 Cooperate to Promote Oriented Epidermal Cell Divisions through LGN.” <i>Nature Cell Biology</i>. Nature Publishing Group, 2014. <a href=\"https://doi.org/10.1038/ncb3001\">https://doi.org/10.1038/ncb3001</a>.","mla":"Williams, Scott, et al. “Par3-MInsc and Gα I3 Cooperate to Promote Oriented Epidermal Cell Divisions through LGN.” <i>Nature Cell Biology</i>, vol. 16, no. 8, Nature Publishing Group, 2014, pp. 758–69, doi:<a href=\"https://doi.org/10.1038/ncb3001\">10.1038/ncb3001</a>.","apa":"Williams, S., Ratliff, L., Postiglione, M. P., Knoblich, J., &#38; Fuchs, E. (2014). Par3-mInsc and Gα i3 cooperate to promote oriented epidermal cell divisions through LGN. <i>Nature Cell Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncb3001\">https://doi.org/10.1038/ncb3001</a>","ama":"Williams S, Ratliff L, Postiglione MP, Knoblich J, Fuchs E. Par3-mInsc and Gα i3 cooperate to promote oriented epidermal cell divisions through LGN. <i>Nature Cell Biology</i>. 2014;16(8):758-769. doi:<a href=\"https://doi.org/10.1038/ncb3001\">10.1038/ncb3001</a>","ieee":"S. Williams, L. Ratliff, M. P. Postiglione, J. Knoblich, and E. Fuchs, “Par3-mInsc and Gα i3 cooperate to promote oriented epidermal cell divisions through LGN,” <i>Nature Cell Biology</i>, vol. 16, no. 8. Nature Publishing Group, pp. 758–769, 2014.","ista":"Williams S, Ratliff L, Postiglione MP, Knoblich J, Fuchs E. 2014. Par3-mInsc and Gα i3 cooperate to promote oriented epidermal cell divisions through LGN. Nature Cell Biology. 16(8), 758–769."},"publication_status":"published","date_created":"2018-12-11T11:54:36Z","_id":"1899","date_published":"2014-07-13T00:00:00Z","title":"Par3-mInsc and Gα i3 cooperate to promote oriented epidermal cell divisions through LGN","publisher":"Nature Publishing Group","department":[{"_id":"SiHi"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"5196","day":"13","pmid":1,"article_processing_charge":"No","status":"public","year":"2014","language":[{"iso":"eng"}],"month":"07","external_id":{"pmid":["25016959"]},"quality_controlled":"1","scopus_import":1,"oa_version":"Submitted Version","oa":1,"volume":16,"publication":"Nature Cell Biology","doi":"10.1038/ncb3001"},{"publication":"Journal of the European Mathematical Society","doi":"10.4171/JEMS/467","project":[{"name":"NSERC Postdoctoral fellowship","_id":"26450934-B435-11E9-9278-68D0E5697425"}],"oa":1,"volume":16,"quality_controlled":"1","scopus_import":1,"oa_version":"Submitted Version","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publist_id":"5191","day":"23","status":"public","language":[{"iso":"eng"}],"year":"2014","month":"08","publisher":"European Mathematical Society","department":[{"_id":"RoSe"}],"citation":{"ista":"Frank R, Lewin M, Lieb É, Seiringer R. 2014. Strichartz inequality for orthonormal functions. Journal of the European Mathematical Society. 16(7), 1507–1526.","chicago":"Frank, Rupert, Mathieu Lewin, Élliott Lieb, and Robert Seiringer. “Strichartz Inequality for Orthonormal Functions.” <i>Journal of the European Mathematical Society</i>. European Mathematical Society, 2014. <a href=\"https://doi.org/10.4171/JEMS/467\">https://doi.org/10.4171/JEMS/467</a>.","mla":"Frank, Rupert, et al. “Strichartz Inequality for Orthonormal Functions.” <i>Journal of the European Mathematical Society</i>, vol. 16, no. 7, European Mathematical Society, 2014, pp. 1507–26, doi:<a href=\"https://doi.org/10.4171/JEMS/467\">10.4171/JEMS/467</a>.","short":"R. Frank, M. Lewin, É. Lieb, R. Seiringer, Journal of the European Mathematical Society 16 (2014) 1507–1526.","ama":"Frank R, Lewin M, Lieb É, Seiringer R. Strichartz inequality for orthonormal functions. <i>Journal of the European Mathematical Society</i>. 2014;16(7):1507-1526. doi:<a href=\"https://doi.org/10.4171/JEMS/467\">10.4171/JEMS/467</a>","ieee":"R. Frank, M. Lewin, É. Lieb, and R. Seiringer, “Strichartz inequality for orthonormal functions,” <i>Journal of the European Mathematical Society</i>, vol. 16, no. 7. European Mathematical Society, pp. 1507–1526, 2014.","apa":"Frank, R., Lewin, M., Lieb, É., &#38; Seiringer, R. (2014). Strichartz inequality for orthonormal functions. <i>Journal of the European Mathematical Society</i>. European Mathematical Society. <a href=\"https://doi.org/10.4171/JEMS/467\">https://doi.org/10.4171/JEMS/467</a>"},"publication_status":"published","date_created":"2018-12-11T11:54:38Z","_id":"1904","date_published":"2014-08-23T00:00:00Z","title":"Strichartz inequality for orthonormal functions","date_updated":"2021-01-12T06:53:58Z","page":"1507 - 1526","abstract":[{"text":"We prove a Strichartz inequality for a system of orthonormal functions, with an optimal behavior of the constant in the limit of a large number of functions. The estimate generalizes the usual Strichartz inequality, in the same fashion as the Lieb-Thirring inequality generalizes the Sobolev inequality. As an application, we consider the Schrödinger equation with a time-dependent potential and we show the existence of the wave operator in Schatten spaces.","lang":"eng"}],"issue":"7","main_file_link":[{"url":"http://arxiv.org/abs/1306.1309","open_access":"1"}],"author":[{"last_name":"Frank","full_name":"Frank, Rupert","first_name":"Rupert"},{"first_name":"Mathieu","full_name":"Lewin, Mathieu","last_name":"Lewin"},{"first_name":"Élliott","full_name":"Lieb, Élliott","last_name":"Lieb"},{"last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","first_name":"Robert"}],"intvolume":"        16","type":"journal_article"},{"ddc":["000"],"type":"journal_article","intvolume":"        20","date_updated":"2021-01-12T06:53:59Z","abstract":[{"lang":"eng","text":"In this paper, we introduce a novel scene representation for the visualization of large-scale point clouds accompanied by a set of high-resolution photographs. Many real-world applications deal with very densely sampled point-cloud data, which are augmented with photographs that often reveal lighting variations and inaccuracies in registration. Consequently, the high-quality representation of the captured data, i.e., both point clouds and photographs together, is a challenging and time-consuming task. We propose a two-phase approach, in which the first (preprocessing) phase generates multiple overlapping surface patches and handles the problem of seamless texture generation locally for each patch. The second phase stitches these patches at render-time to produce a high-quality visualization of the data. As a result of the proposed localization of the global texturing problem, our algorithm is more than an order of magnitude faster than equivalent mesh-based texturing techniques. Furthermore, since our preprocessing phase requires only a minor fraction of the whole data set at once, we provide maximum flexibility when dealing with growing data sets."}],"page":"1280 - 1292","file_date_updated":"2020-07-14T12:45:20Z","issue":"9","acknowledgement":"This research was supported by the Austrian Research Promotion Agency (FFG) project REPLICATE (no. 835948), the EU FP7 project HARVEST4D (no. 323567).","author":[{"last_name":"Arikan","full_name":"Arikan, Murat","first_name":"Murat"},{"full_name":"Preiner, Reinhold","first_name":"Reinhold","last_name":"Preiner"},{"full_name":"Scheiblauer, Claus","first_name":"Claus","last_name":"Scheiblauer"},{"first_name":"Stefan","full_name":"Jeschke, Stefan","last_name":"Jeschke","id":"44D6411A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Wimmer, Michael","first_name":"Michael","last_name":"Wimmer"}],"date_created":"2018-12-11T11:54:39Z","citation":{"ista":"Arikan M, Preiner R, Scheiblauer C, Jeschke S, Wimmer M. 2014. Large-scale point-cloud visualization through localized textured surface reconstruction. IEEE Transactions on Visualization and Computer Graphics. 20(9), 1280–1292.","apa":"Arikan, M., Preiner, R., Scheiblauer, C., Jeschke, S., &#38; Wimmer, M. (2014). Large-scale point-cloud visualization through localized textured surface reconstruction. <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE. <a href=\"https://doi.org/10.1109/TVCG.2014.2312011\">https://doi.org/10.1109/TVCG.2014.2312011</a>","ama":"Arikan M, Preiner R, Scheiblauer C, Jeschke S, Wimmer M. Large-scale point-cloud visualization through localized textured surface reconstruction. <i>IEEE Transactions on Visualization and Computer Graphics</i>. 2014;20(9):1280-1292. doi:<a href=\"https://doi.org/10.1109/TVCG.2014.2312011\">10.1109/TVCG.2014.2312011</a>","ieee":"M. Arikan, R. Preiner, C. Scheiblauer, S. Jeschke, and M. Wimmer, “Large-scale point-cloud visualization through localized textured surface reconstruction,” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 20, no. 9. IEEE, pp. 1280–1292, 2014.","short":"M. Arikan, R. Preiner, C. Scheiblauer, S. Jeschke, M. Wimmer, IEEE Transactions on Visualization and Computer Graphics 20 (2014) 1280–1292.","mla":"Arikan, Murat, et al. “Large-Scale Point-Cloud Visualization through Localized Textured Surface Reconstruction.” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 20, no. 9, IEEE, 2014, pp. 1280–92, doi:<a href=\"https://doi.org/10.1109/TVCG.2014.2312011\">10.1109/TVCG.2014.2312011</a>.","chicago":"Arikan, Murat, Reinhold Preiner, Claus Scheiblauer, Stefan Jeschke, and Michael Wimmer. “Large-Scale Point-Cloud Visualization through Localized Textured Surface Reconstruction.” <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE, 2014. <a href=\"https://doi.org/10.1109/TVCG.2014.2312011\">https://doi.org/10.1109/TVCG.2014.2312011</a>."},"publication_status":"published","_id":"1906","date_published":"2014-09-09T00:00:00Z","title":"Large-scale point-cloud visualization through localized textured surface reconstruction","file":[{"content_type":"application/pdf","date_created":"2018-12-12T10:17:41Z","file_name":"IST-2016-573-v1+1_arikan-2014-pcvis-draft.pdf","file_size":13594598,"file_id":"5297","creator":"system","access_level":"open_access","relation":"main_file","checksum":"5bf58942d2eb20adf03c7f9ea2e68124","date_updated":"2020-07-14T12:45:20Z"}],"department":[{"_id":"ChWo"}],"publisher":"IEEE","pubrep_id":"573","publist_id":"5189","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","day":"09","year":"2014","language":[{"iso":"eng"}],"status":"public","month":"09","has_accepted_license":"1","scopus_import":1,"oa_version":"Submitted Version","volume":20,"oa":1,"publication":"IEEE Transactions on Visualization and Computer Graphics","project":[{"call_identifier":"FWF","grant_number":"P 24352-N23","_id":"25357BD2-B435-11E9-9278-68D0E5697425","name":"Deep Pictures: Creating Visual and Haptic Vector Images"}],"doi":"10.1109/TVCG.2014.2312011"},{"publication_status":"published","citation":{"ista":"Demay G, Gazi P, Maurer U, Tackmann B. 2014. Optimality of non-adaptive strategies: The case of parallel games. IEEE International Symposium on Information Theory. IEEE International Symposium on Information Theory Proceedings, 6875125.","apa":"Demay, G., Gazi, P., Maurer, U., &#38; Tackmann, B. (2014). Optimality of non-adaptive strategies: The case of parallel games. In <i>IEEE International Symposium on Information Theory</i>. Honolulu, USA: IEEE. <a href=\"https://doi.org/10.1109/ISIT.2014.6875125\">https://doi.org/10.1109/ISIT.2014.6875125</a>","ama":"Demay G, Gazi P, Maurer U, Tackmann B. Optimality of non-adaptive strategies: The case of parallel games. In: <i>IEEE International Symposium on Information Theory</i>. IEEE; 2014. doi:<a href=\"https://doi.org/10.1109/ISIT.2014.6875125\">10.1109/ISIT.2014.6875125</a>","ieee":"G. Demay, P. Gazi, U. Maurer, and B. Tackmann, “Optimality of non-adaptive strategies: The case of parallel games,” in <i>IEEE International Symposium on Information Theory</i>, Honolulu, USA, 2014.","short":"G. Demay, P. Gazi, U. Maurer, B. Tackmann, in:, IEEE International Symposium on Information Theory, IEEE, 2014.","chicago":"Demay, Grégory, Peter Gazi, Ueli Maurer, and Björn Tackmann. “Optimality of Non-Adaptive Strategies: The Case of Parallel Games.” In <i>IEEE International Symposium on Information Theory</i>. IEEE, 2014. <a href=\"https://doi.org/10.1109/ISIT.2014.6875125\">https://doi.org/10.1109/ISIT.2014.6875125</a>.","mla":"Demay, Grégory, et al. “Optimality of Non-Adaptive Strategies: The Case of Parallel Games.” <i>IEEE International Symposium on Information Theory</i>, 6875125, IEEE, 2014, doi:<a href=\"https://doi.org/10.1109/ISIT.2014.6875125\">10.1109/ISIT.2014.6875125</a>."},"date_created":"2018-12-11T11:54:39Z","oa":1,"title":"Optimality of non-adaptive strategies: The case of parallel games","_id":"1907","date_published":"2014-01-01T00:00:00Z","publication":"IEEE International Symposium on Information Theory","publisher":"IEEE","doi":"10.1109/ISIT.2014.6875125","department":[{"_id":"KrPi"}],"day":"01","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publist_id":"5188","month":"01","year":"2014","type":"conference","status":"public","language":[{"iso":"eng"}],"conference":{"location":"Honolulu, USA","name":"IEEE International Symposium on Information Theory Proceedings","start_date":"2014-06-29","end_date":"2014-07-04"},"quality_controlled":"1","article_number":"6875125","abstract":[{"lang":"eng","text":"Most cryptographic security proofs require showing that two systems are indistinguishable. A central tool in such proofs is that of a game, where winning the game means provoking a certain condition, and it is shown that the two systems considered cannot be distinguished unless this condition is provoked. Upper bounding the probability of winning such a game, i.e., provoking this condition, for an arbitrary strategy is usually hard, except in the special case where the best strategy for winning such a game is known to be non-adaptive. A sufficient criterion for ensuring the optimality of non-adaptive strategies is that of conditional equivalence to a system, a notion introduced in [1]. In this paper, we show that this criterion is not necessary to ensure the optimality of non-adaptive strategies by giving two results of independent interest: 1) the optimality of non-adaptive strategies is not preserved under parallel composition; 2) in contrast, conditional equivalence is preserved under parallel composition."}],"date_updated":"2021-01-12T06:53:59Z","author":[{"full_name":"Demay, Grégory","first_name":"Grégory","last_name":"Demay"},{"last_name":"Gazi","id":"3E0BFE38-F248-11E8-B48F-1D18A9856A87","full_name":"Gazi, Peter","first_name":"Peter"},{"last_name":"Maurer","first_name":"Ueli","full_name":"Maurer, Ueli"},{"last_name":"Tackmann","first_name":"Björn","full_name":"Tackmann, Björn"}],"main_file_link":[{"url":"https://eprint.iacr.org/2014/299","open_access":"1"}],"oa_version":"Submitted Version","scopus_import":1},{"day":"01","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","publist_id":"5187","month":"04","status":"public","language":[{"iso":"eng"}],"year":"2014","quality_controlled":"1","oa_version":"Submitted Version","scopus_import":1,"oa":1,"volume":196,"publication":"Genetics","doi":"10.1534/genetics.113.160705","project":[{"grant_number":"250152","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","_id":"25B07788-B435-11E9-9278-68D0E5697425"}],"intvolume":"       196","type":"journal_article","page":"1167 - 1183","abstract":[{"text":"In large populations, multiple beneficial mutations may be simultaneously spreading. In asexual populations, these mutations must either arise on the same background or compete against each other. In sexual populations, recombination can bring together beneficial alleles from different backgrounds, but tightly linked alleles may still greatly interfere with each other. We show for well-mixed populations that when this interference is strong, the genome can be seen as consisting of many effectively asexual stretches linked together. The rate at which beneficial alleles fix is thus roughly proportional to the rate of recombination and depends only logarithmically on the mutation supply and the strength of selection. Our scaling arguments also allow us to predict, with reasonable accuracy, the fitness distribution of fixed mutations when the mutational effect sizes are broad. We focus on the regime in which crossovers occur more frequently than beneficial mutations, as is likely to be the case for many natural populations.","lang":"eng"}],"date_updated":"2021-01-12T06:53:59Z","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1307.0737"}],"author":[{"full_name":"Weissman, Daniel","first_name":"Daniel","id":"2D0CE020-F248-11E8-B48F-1D18A9856A87","last_name":"Weissman"},{"last_name":"Hallatschek","full_name":"Hallatschek, Oskar","first_name":"Oskar"}],"issue":"4","publication_status":"published","citation":{"ista":"Weissman D, Hallatschek O. 2014. The rate of adaptation in large sexual populations with linear chromosomes. Genetics. 196(4), 1167–1183.","apa":"Weissman, D., &#38; Hallatschek, O. (2014). The rate of adaptation in large sexual populations with linear chromosomes. <i>Genetics</i>. Genetics Society of America. <a href=\"https://doi.org/10.1534/genetics.113.160705\">https://doi.org/10.1534/genetics.113.160705</a>","ama":"Weissman D, Hallatschek O. The rate of adaptation in large sexual populations with linear chromosomes. <i>Genetics</i>. 2014;196(4):1167-1183. doi:<a href=\"https://doi.org/10.1534/genetics.113.160705\">10.1534/genetics.113.160705</a>","ieee":"D. Weissman and O. Hallatschek, “The rate of adaptation in large sexual populations with linear chromosomes,” <i>Genetics</i>, vol. 196, no. 4. Genetics Society of America, pp. 1167–1183, 2014.","short":"D. Weissman, O. Hallatschek, Genetics 196 (2014) 1167–1183.","chicago":"Weissman, Daniel, and Oskar Hallatschek. “The Rate of Adaptation in Large Sexual Populations with Linear Chromosomes.” <i>Genetics</i>. Genetics Society of America, 2014. <a href=\"https://doi.org/10.1534/genetics.113.160705\">https://doi.org/10.1534/genetics.113.160705</a>.","mla":"Weissman, Daniel, and Oskar Hallatschek. “The Rate of Adaptation in Large Sexual Populations with Linear Chromosomes.” <i>Genetics</i>, vol. 196, no. 4, Genetics Society of America, 2014, pp. 1167–83, doi:<a href=\"https://doi.org/10.1534/genetics.113.160705\">10.1534/genetics.113.160705</a>."},"date_created":"2018-12-11T11:54:39Z","title":"The rate of adaptation in large sexual populations with linear chromosomes","ec_funded":1,"_id":"1908","date_published":"2014-04-01T00:00:00Z","publisher":"Genetics Society of America","department":[{"_id":"NiBa"}]},{"oa_version":"Published Version","scopus_import":1,"has_accepted_license":"1","month":"06","status":"public","language":[{"iso":"eng"}],"year":"2014","day":"01","pubrep_id":"419","publist_id":"5186","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","doi":"10.1111/1365-2435.12207","publication":"Functional Ecology","volume":28,"oa":1,"acknowledgement":"Engineering and Physical Sciences Research Council. Grant Number: EP/H031928/1","author":[{"full_name":"Ezard, Thomas","first_name":"Thomas","last_name":"Ezard"},{"full_name":"Prizak, Roshan","first_name":"Roshan","last_name":"Prizak","id":"4456104E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Hoyle, Rebecca","first_name":"Rebecca","last_name":"Hoyle"}],"file_date_updated":"2020-07-14T12:45:20Z","issue":"3","page":"693 - 701","abstract":[{"text":"Summary: Phenotypes are often environmentally dependent, which requires organisms to track environmental change. The challenge for organisms is to construct phenotypes using the most accurate environmental cue. Here, we use a quantitative genetic model of adaptation by additive genetic variance, within- and transgenerational plasticity via linear reaction norms and indirect genetic effects respectively. We show how the relative influence on the eventual phenotype of these components depends on the predictability of environmental change (fast or slow, sinusoidal or stochastic) and the developmental lag τ between when the environment is perceived and when selection acts. We then decompose expected mean fitness into three components (variance load, adaptation and fluctuation load) to study the fitness costs of within- and transgenerational plasticity. A strongly negative maternal effect coefficient m minimizes the variance load, but a strongly positive m minimises the fluctuation load. The adaptation term is maximized closer to zero, with positive or negative m preferred under different environmental scenarios. Phenotypic plasticity is higher when τ is shorter and when the environment changes frequently between seasonal extremes. Expected mean population fitness is highest away from highest observed levels of phenotypic plasticity. Within- and transgenerational plasticity act in concert to deliver well-adapted phenotypes, which emphasizes the need to study both simultaneously when investigating phenotypic evolution.","lang":"eng"}],"date_updated":"2021-01-12T06:54:00Z","type":"journal_article","intvolume":"        28","ddc":["570"],"department":[{"_id":"NiBa"},{"_id":"GaTk"}],"publisher":"Wiley-Blackwell","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"date_updated":"2020-07-14T12:45:20Z","checksum":"3cbe8623174709a8ceec2103246f8fe0","access_level":"open_access","relation":"main_file","file_id":"5167","file_size":536154,"creator":"system","file_name":"IST-2016-419-v1+1_Ezard_et_al-2014-Functional_Ecology.pdf","date_created":"2018-12-12T10:15:45Z","content_type":"application/pdf"}],"license":"https://creativecommons.org/licenses/by/4.0/","title":"The fitness costs of adaptation via phenotypic plasticity and maternal effects","_id":"1909","date_published":"2014-06-01T00:00:00Z","date_created":"2018-12-11T11:54:40Z","citation":{"short":"T. Ezard, R. Prizak, R. Hoyle, Functional Ecology 28 (2014) 693–701.","mla":"Ezard, Thomas, et al. “The Fitness Costs of Adaptation via Phenotypic Plasticity and Maternal Effects.” <i>Functional Ecology</i>, vol. 28, no. 3, Wiley-Blackwell, 2014, pp. 693–701, doi:<a href=\"https://doi.org/10.1111/1365-2435.12207\">10.1111/1365-2435.12207</a>.","chicago":"Ezard, Thomas, Roshan Prizak, and Rebecca Hoyle. “The Fitness Costs of Adaptation via Phenotypic Plasticity and Maternal Effects.” <i>Functional Ecology</i>. Wiley-Blackwell, 2014. <a href=\"https://doi.org/10.1111/1365-2435.12207\">https://doi.org/10.1111/1365-2435.12207</a>.","apa":"Ezard, T., Prizak, R., &#38; Hoyle, R. (2014). The fitness costs of adaptation via phenotypic plasticity and maternal effects. <i>Functional Ecology</i>. Wiley-Blackwell. <a href=\"https://doi.org/10.1111/1365-2435.12207\">https://doi.org/10.1111/1365-2435.12207</a>","ieee":"T. Ezard, R. Prizak, and R. Hoyle, “The fitness costs of adaptation via phenotypic plasticity and maternal effects,” <i>Functional Ecology</i>, vol. 28, no. 3. Wiley-Blackwell, pp. 693–701, 2014.","ama":"Ezard T, Prizak R, Hoyle R. The fitness costs of adaptation via phenotypic plasticity and maternal effects. <i>Functional Ecology</i>. 2014;28(3):693-701. doi:<a href=\"https://doi.org/10.1111/1365-2435.12207\">10.1111/1365-2435.12207</a>","ista":"Ezard T, Prizak R, Hoyle R. 2014. The fitness costs of adaptation via phenotypic plasticity and maternal effects. Functional Ecology. 28(3), 693–701."},"publication_status":"published"},{"title":"The notochord breaks bilateral symmetry by controlling cell shapes in the Zebrafish laterality organ","date_published":"2014-12-22T00:00:00Z","_id":"1912","date_created":"2018-12-11T11:54:41Z","citation":{"ama":"Compagnon J, Barone V, Rajshekar S, et al. The notochord breaks bilateral symmetry by controlling cell shapes in the Zebrafish laterality organ. <i>Developmental Cell</i>. 2014;31(6):774-783. doi:<a href=\"https://doi.org/10.1016/j.devcel.2014.11.003\">10.1016/j.devcel.2014.11.003</a>","ieee":"J. Compagnon <i>et al.</i>, “The notochord breaks bilateral symmetry by controlling cell shapes in the Zebrafish laterality organ,” <i>Developmental Cell</i>, vol. 31, no. 6. Cell Press, pp. 774–783, 2014.","apa":"Compagnon, J., Barone, V., Rajshekar, S., Kottmeier, R., Pranjic-Ferscha, K., Behrndt, M., &#38; Heisenberg, C.-P. J. (2014). The notochord breaks bilateral symmetry by controlling cell shapes in the Zebrafish laterality organ. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2014.11.003\">https://doi.org/10.1016/j.devcel.2014.11.003</a>","chicago":"Compagnon, Julien, Vanessa Barone, Srivarsha Rajshekar, Rita Kottmeier, Kornelija Pranjic-Ferscha, Martin Behrndt, and Carl-Philipp J Heisenberg. “The Notochord Breaks Bilateral Symmetry by Controlling Cell Shapes in the Zebrafish Laterality Organ.” <i>Developmental Cell</i>. Cell Press, 2014. <a href=\"https://doi.org/10.1016/j.devcel.2014.11.003\">https://doi.org/10.1016/j.devcel.2014.11.003</a>.","mla":"Compagnon, Julien, et al. “The Notochord Breaks Bilateral Symmetry by Controlling Cell Shapes in the Zebrafish Laterality Organ.” <i>Developmental Cell</i>, vol. 31, no. 6, Cell Press, 2014, pp. 774–83, doi:<a href=\"https://doi.org/10.1016/j.devcel.2014.11.003\">10.1016/j.devcel.2014.11.003</a>.","short":"J. Compagnon, V. Barone, S. Rajshekar, R. Kottmeier, K. Pranjic-Ferscha, M. Behrndt, C.-P.J. Heisenberg, Developmental Cell 31 (2014) 774–783.","ista":"Compagnon J, Barone V, Rajshekar S, Kottmeier R, Pranjic-Ferscha K, Behrndt M, Heisenberg C-PJ. 2014. The notochord breaks bilateral symmetry by controlling cell shapes in the Zebrafish laterality organ. Developmental Cell. 31(6), 774–783."},"publication_status":"published","department":[{"_id":"CaHe"}],"publisher":"Cell Press","intvolume":"        31","type":"journal_article","acknowledgement":"We are grateful to members of the C.-P.H. lab, M. Concha, D. Siekhaus, and J. Vermot for comments on the manuscript and to M. Furutani-Seiki for sharing reagents. This work was supported by the Institute of Science and Technology Austria and an Alexander von Humboldt Foundation fellowship to J.C.","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pubmed/25535919"}],"author":[{"first_name":"Julien","full_name":"Compagnon, Julien","last_name":"Compagnon","id":"2E3E0988-F248-11E8-B48F-1D18A9856A87"},{"id":"419EECCC-F248-11E8-B48F-1D18A9856A87","last_name":"Barone","full_name":"Barone, Vanessa","first_name":"Vanessa","orcid":"0000-0003-2676-3367"},{"first_name":"Srivarsha","full_name":"Rajshekar, Srivarsha","last_name":"Rajshekar"},{"last_name":"Kottmeier","full_name":"Kottmeier, Rita","first_name":"Rita"},{"full_name":"Pranjic-Ferscha, Kornelija","first_name":"Kornelija","id":"4362B3C2-F248-11E8-B48F-1D18A9856A87","last_name":"Pranjic-Ferscha"},{"id":"3ECECA3A-F248-11E8-B48F-1D18A9856A87","last_name":"Behrndt","full_name":"Behrndt, Martin","first_name":"Martin"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566"}],"issue":"6","page":"774 - 783","abstract":[{"text":"Kupffer's vesicle (KV) is the zebrafish organ of laterality, patterning the embryo along its left-right (LR) axis. Regional differences in cell shape within the lumen-lining KV epithelium are essential for its LR patterning function. However, the processes by which KV cells acquire their characteristic shapes are largely unknown. Here, we show that the notochord induces regional differences in cell shape within KV by triggering extracellular matrix (ECM) accumulation adjacent to anterior-dorsal (AD) regions of KV. This localized ECM deposition restricts apical expansion of lumen-lining epithelial cells in AD regions of KV during lumen growth. Our study provides mechanistic insight into the processes by which KV translates global embryonic patterning into regional cell shape differences required for its LR symmetry-breaking function.","lang":"eng"}],"date_updated":"2023-09-07T12:05:08Z","volume":31,"oa":1,"doi":"10.1016/j.devcel.2014.11.003","publication":"Developmental Cell","month":"12","status":"public","year":"2014","language":[{"iso":"eng"}],"article_processing_charge":"No","pmid":1,"day":"22","publist_id":"5182","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","scopus_import":"1","related_material":{"record":[{"relation":"dissertation_contains","id":"961","status":"public"}]},"quality_controlled":"1","external_id":{"pmid":["25535919"]}},{"type":"journal_article","intvolume":"        38","publication_identifier":{"issn":["1420-8008"]},"issue":"5-6","main_file_link":[{"url":"https://kops.uni-konstanz.de/bitstream/123456789/42127/1/Milenkovic_2-17ivylo2up0798.pdf","open_access":"1"}],"author":[{"last_name":"Milenković","first_name":"Ivan","full_name":"Milenković, Ivan"},{"id":"3D5811FC-F248-11E8-B48F-1D18A9856A87","last_name":"Petrov","orcid":"0000-0002-9041-0905","first_name":"Tatjana","full_name":"Petrov, Tatjana"},{"last_name":"Kovács","full_name":"Kovács, Gábor","first_name":"Gábor"}],"acknowledgement":"This study was supported by the European Commission’s 7th Framework Programme under GA No. 278486, ‘DEVELAGE’.","date_updated":"2023-10-17T10:21:17Z","article_type":"original","page":"375 - 388","abstract":[{"text":"Deposits of phosphorylated tau protein and convergence of pathology in the hippocampus are the hallmarks of neurodegenerative tauopathies. Thus we aimed to evaluate whether regional and cellular vulnerability patterns in the hippocampus distinguish tauopathies or are influenced by their concomitant presence. Methods: We created a heat map of phospho-tau (AT8) immunoreactivity patterns in 24 hippocampal subregions/layers in individuals with Alzheimer's disease (AD)-related neurofibrillary degeneration (n = 40), Pick's disease (n = 8), progressive supranuclear palsy (n = 7), corticobasal degeneration (n = 6), argyrophilic grain disease (AGD, n = 18), globular glial tauopathy (n = 5), and tau-astrogliopathy of the elderly (n = 10). AT8 immunoreactivity patterns were compared by mathematical analysis. Results: Our study reveals disease-specific hot spots and regional selective vulnerability for these disorders. The pattern of hippocampal AD-related tau pathology is strongly influenced by concomitant AGD. Mathematical analysis reveals that hippocampal involvement in primary tauopathies is distinguishable from early-stage AD-related neurofibrillary degeneration. Conclusion: Our data demonstrate disease-specific AT8 immunoreactivity patterns and hot spots in the hippocampus even in tauopathies, which primarily do not affect the hippocampus. These hot spots can be shifted to other regions by the co-occurrence of tauopathies like AGD. Our observations support the notion that globular glial tauopathies and tau-astrogliopathy of the elderly are distinct entities.","lang":"eng"}],"_id":"1913","date_published":"2014-11-07T00:00:00Z","title":"Patterns of hippocampal tau pathology differentiate neurodegenerative dementias","date_created":"2018-12-11T11:54:41Z","citation":{"ista":"Milenković I, Petrov T, Kovács G. 2014. Patterns of hippocampal tau pathology differentiate neurodegenerative dementias. Dementia and Geriatric Cognitive Disorders. 38(5–6), 375–388.","apa":"Milenković, I., Petrov, T., &#38; Kovács, G. (2014). Patterns of hippocampal tau pathology differentiate neurodegenerative dementias. <i>Dementia and Geriatric Cognitive Disorders</i>. Karger Publishers. <a href=\"https://doi.org/10.1159/000365548\">https://doi.org/10.1159/000365548</a>","ieee":"I. Milenković, T. Petrov, and G. Kovács, “Patterns of hippocampal tau pathology differentiate neurodegenerative dementias,” <i>Dementia and Geriatric Cognitive Disorders</i>, vol. 38, no. 5–6. Karger Publishers, pp. 375–388, 2014.","ama":"Milenković I, Petrov T, Kovács G. Patterns of hippocampal tau pathology differentiate neurodegenerative dementias. <i>Dementia and Geriatric Cognitive Disorders</i>. 2014;38(5-6):375-388. doi:<a href=\"https://doi.org/10.1159/000365548\">10.1159/000365548</a>","short":"I. Milenković, T. Petrov, G. Kovács, Dementia and Geriatric Cognitive Disorders 38 (2014) 375–388.","mla":"Milenković, Ivan, et al. “Patterns of Hippocampal Tau Pathology Differentiate Neurodegenerative Dementias.” <i>Dementia and Geriatric Cognitive Disorders</i>, vol. 38, no. 5–6, Karger Publishers, 2014, pp. 375–88, doi:<a href=\"https://doi.org/10.1159/000365548\">10.1159/000365548</a>.","chicago":"Milenković, Ivan, Tatjana Petrov, and Gábor Kovács. “Patterns of Hippocampal Tau Pathology Differentiate Neurodegenerative Dementias.” <i>Dementia and Geriatric Cognitive Disorders</i>. Karger Publishers, 2014. <a href=\"https://doi.org/10.1159/000365548\">https://doi.org/10.1159/000365548</a>."},"publication_status":"published","department":[{"_id":"CaGu"}],"publisher":"Karger Publishers","year":"2014","status":"public","language":[{"iso":"eng"}],"article_processing_charge":"No","month":"11","publist_id":"5181","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"day":"07","scopus_import":"1","oa_version":"Published Version","external_id":{"pmid":["25195847"]},"quality_controlled":"1","volume":38,"oa":1,"doi":"10.1159/000365548","publication":"Dementia and Geriatric Cognitive Disorders"},{"publisher":"American Association for the Advancement of Science","department":[{"_id":"GaNo"}],"title":"Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders","date_published":"2014-01-31T00:00:00Z","_id":"1916","citation":{"ista":"Novarino G, Fenstermaker A, Zaki M, Hofree M, Silhavy J, Heiberg A, Abdellateef M, Rosti B, Scott E, Mansour L, Masri A, Kayserili H, Al Aama J, Abdel Salam G, Karminejad A, Kara M, Kara B, Bozorgmehri B, Ben Omran T, Mojahedi F, Mahmoud I, Bouslam N, Bouhouche A, Benomar A, Hanein S, Raymond L, Forlani S, Mascaro M, Selim L, Shehata N, Al Allawi N, Bindu P, Azam M, Günel M, Caglayan A, Bilgüvar K, Tolun A, Issa M, Schroth J, Spencer E, Rosti R, Akizu N, Vaux K, Johansen A, Koh A, Megahed H, Dürr A, Brice A, Stévanin G, Gabriel S, Ideker T, Gleeson J. 2014. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. Science. 343(6170), 506–511.","short":"G. Novarino, A. Fenstermaker, M. Zaki, M. Hofree, J. Silhavy, A. Heiberg, M. Abdellateef, B. Rosti, E. Scott, L. Mansour, A. Masri, H. Kayserili, J. Al Aama, G. Abdel Salam, A. Karminejad, M. Kara, B. Kara, B. Bozorgmehri, T. Ben Omran, F. Mojahedi, I. Mahmoud, N. Bouslam, A. Bouhouche, A. Benomar, S. Hanein, L. Raymond, S. Forlani, M. Mascaro, L. Selim, N. Shehata, N. Al Allawi, P. Bindu, M. Azam, M. Günel, A. Caglayan, K. Bilgüvar, A. Tolun, M. Issa, J. Schroth, E. Spencer, R. Rosti, N. Akizu, K. Vaux, A. Johansen, A. Koh, H. Megahed, A. Dürr, A. Brice, G. Stévanin, S. Gabriel, T. Ideker, J. Gleeson, Science 343 (2014) 506–511.","chicago":"Novarino, Gaia, Ali Fenstermaker, Maha Zaki, Matan Hofree, Jennifer Silhavy, Andrew Heiberg, Mostafa Abdellateef, et al. “Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders.” <i>Science</i>. American Association for the Advancement of Science, 2014. <a href=\"https://doi.org/10.1126/science.1247363\">https://doi.org/10.1126/science.1247363</a>.","mla":"Novarino, Gaia, et al. “Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders.” <i>Science</i>, vol. 343, no. 6170, American Association for the Advancement of Science, 2014, pp. 506–11, doi:<a href=\"https://doi.org/10.1126/science.1247363\">10.1126/science.1247363</a>.","apa":"Novarino, G., Fenstermaker, A., Zaki, M., Hofree, M., Silhavy, J., Heiberg, A., … Gleeson, J. (2014). Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1247363\">https://doi.org/10.1126/science.1247363</a>","ama":"Novarino G, Fenstermaker A, Zaki M, et al. Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders. <i>Science</i>. 2014;343(6170):506-511. doi:<a href=\"https://doi.org/10.1126/science.1247363\">10.1126/science.1247363</a>","ieee":"G. Novarino <i>et al.</i>, “Exome sequencing links corticospinal motor neuron disease to common neurodegenerative disorders,” <i>Science</i>, vol. 343, no. 6170. American Association for the Advancement of Science, pp. 506–511, 2014."},"publication_status":"published","date_created":"2018-12-11T11:54:42Z","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157572/"}],"author":[{"orcid":"0000-0002-7673-7178","first_name":"Gaia","full_name":"Novarino, Gaia","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Fenstermaker","first_name":"Ali","full_name":"Fenstermaker, Ali"},{"last_name":"Zaki","full_name":"Zaki, Maha","first_name":"Maha"},{"first_name":"Matan","full_name":"Hofree, Matan","last_name":"Hofree"},{"full_name":"Silhavy, Jennifer","first_name":"Jennifer","last_name":"Silhavy"},{"first_name":"Andrew","full_name":"Heiberg, Andrew","last_name":"Heiberg"},{"full_name":"Abdellateef, Mostafa","first_name":"Mostafa","last_name":"Abdellateef"},{"last_name":"Rosti","first_name":"Başak","full_name":"Rosti, Başak"},{"full_name":"Scott, Eric","first_name":"Eric","last_name":"Scott"},{"last_name":"Mansour","full_name":"Mansour, Lobna","first_name":"Lobna"},{"last_name":"Masri","first_name":"Amira","full_name":"Masri, Amira"},{"first_name":"Hülya","full_name":"Kayserili, Hülya","last_name":"Kayserili"},{"last_name":"Al Aama","full_name":"Al Aama, Jumana","first_name":"Jumana"},{"first_name":"Ghada","full_name":"Abdel Salam, Ghada","last_name":"Abdel Salam"},{"last_name":"Karminejad","full_name":"Karminejad, Ariana","first_name":"Ariana"},{"last_name":"Kara","full_name":"Kara, Majdi","first_name":"Majdi"},{"last_name":"Kara","full_name":"Kara, Bülent","first_name":"Bülent"},{"last_name":"Bozorgmehri","first_name":"Bita","full_name":"Bozorgmehri, Bita"},{"full_name":"Ben Omran, Tawfeg","first_name":"Tawfeg","last_name":"Ben Omran"},{"last_name":"Mojahedi","first_name":"Faezeh","full_name":"Mojahedi, Faezeh"},{"last_name":"Mahmoud","first_name":"Iman","full_name":"Mahmoud, Iman"},{"full_name":"Bouslam, Naïma","first_name":"Naïma","last_name":"Bouslam"},{"last_name":"Bouhouche","full_name":"Bouhouche, Ahmed","first_name":"Ahmed"},{"last_name":"Benomar","full_name":"Benomar, Ali","first_name":"Ali"},{"full_name":"Hanein, Sylvain","first_name":"Sylvain","last_name":"Hanein"},{"last_name":"Raymond","first_name":"Laure","full_name":"Raymond, Laure"},{"last_name":"Forlani","full_name":"Forlani, Sylvie","first_name":"Sylvie"},{"full_name":"Mascaro, Massimo","first_name":"Massimo","last_name":"Mascaro"},{"last_name":"Selim","first_name":"Laila","full_name":"Selim, Laila"},{"last_name":"Shehata","full_name":"Shehata, Nabil","first_name":"Nabil"},{"full_name":"Al Allawi, Nasir","first_name":"Nasir","last_name":"Al Allawi"},{"last_name":"Bindu","full_name":"Bindu, Parayil","first_name":"Parayil"},{"last_name":"Azam","first_name":"Matloob","full_name":"Azam, Matloob"},{"full_name":"Günel, Murat","first_name":"Murat","last_name":"Günel"},{"full_name":"Caglayan, Ahmet","first_name":"Ahmet","last_name":"Caglayan"},{"first_name":"Kaya","full_name":"Bilgüvar, Kaya","last_name":"Bilgüvar"},{"full_name":"Tolun, Aslihan","first_name":"Aslihan","last_name":"Tolun"},{"full_name":"Issa, Mahmoud","first_name":"Mahmoud","last_name":"Issa"},{"last_name":"Schroth","full_name":"Schroth, Jana","first_name":"Jana"},{"last_name":"Spencer","first_name":"Emily","full_name":"Spencer, Emily"},{"full_name":"Rosti, Rasim","first_name":"Rasim","last_name":"Rosti"},{"last_name":"Akizu","full_name":"Akizu, Naiara","first_name":"Naiara"},{"first_name":"Keith","full_name":"Vaux, Keith","last_name":"Vaux"},{"last_name":"Johansen","first_name":"Anide","full_name":"Johansen, Anide"},{"first_name":"Alice","full_name":"Koh, Alice","last_name":"Koh"},{"last_name":"Megahed","first_name":"Hisham","full_name":"Megahed, Hisham"},{"full_name":"Dürr, Alexandra","first_name":"Alexandra","last_name":"Dürr"},{"full_name":"Brice, Alexis","first_name":"Alexis","last_name":"Brice"},{"full_name":"Stévanin, Giovanni","first_name":"Giovanni","last_name":"Stévanin"},{"full_name":"Gabriel, Stacy","first_name":"Stacy","last_name":"Gabriel"},{"full_name":"Ideker, Trey","first_name":"Trey","last_name":"Ideker"},{"first_name":"Joseph","full_name":"Gleeson, Joseph","last_name":"Gleeson"}],"acknowledgement":"Supported by the Deutsche Forschungsgemeinschaft (G.N.)","issue":"6170","page":"506 - 511","article_type":"original","abstract":[{"lang":"eng","text":"Hereditary spastic paraplegias (HSPs) are neurodegenerative motor neuron diseases characterized by progressive age-dependent loss of corticospinal motor tract function. Although the genetic basis is partly understood, only a fraction of cases can receive a genetic diagnosis, and a global view of HSP is lacking. By using whole-exome sequencing in combination with network analysis, we identified 18 previously unknown putative HSP genes and validated nearly all of these genes functionally or genetically. The pathways highlighted by these mutations link HSP to cellular transport, nucleotide metabolism, and synapse and axon development. Network analysis revealed a host of further candidate genes, of which three were mutated in our cohort. Our analysis links HSP to other neurodegenerative disorders and can facilitate gene discovery and mechanistic understanding of disease."}],"date_updated":"2021-01-12T06:54:03Z","type":"journal_article","intvolume":"       343","doi":"10.1126/science.1247363","publication":"Science","oa":1,"volume":343,"oa_version":"Submitted Version","scopus_import":1,"quality_controlled":"1","external_id":{"pmid":["24482476"]},"month":"01","article_processing_charge":"No","year":"2014","status":"public","language":[{"iso":"eng"}],"day":"31","pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"5178"},{"date_updated":"2021-01-12T06:54:03Z","article_type":"original","abstract":[{"text":"Auxin-binding protein 1 (ABP1) was discovered nearly 40 years ago and was shown to be essential for plant development and morphogenesis, but its mode of action remains unclear. Here, we report that the plasma membrane-localized transmembrane kinase (TMK) receptor-like kinases interact with ABP1 and transduce auxin signal to activate plasma membrane-associated ROPs [Rho-like guanosine triphosphatases (GTPase) from plants], leading to changes in the cytoskeleton and the shape of leaf pavement cells in Arabidopsis. The interaction between ABP1 and TMK at the cell surface is induced by auxin and requires ABP1 sensing of auxin. These findings show that TMK proteins and ABP1 form a cell surface auxin perception complex that activates ROP signaling pathways, regulating nontranscriptional cytoplasmic responses and associated fundamental processes.","lang":"eng"}],"page":"1025 - 1028","issue":"6174","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166562/","open_access":"1"}],"acknowledgement":"Supported by the intramural research program of the National Institute of Arthritis and Musculoskeletal and Skin Diseases and by its Laboratory Animal Care and Use Section and Flow Cytometry Group, Office of Science and Technology","author":[{"last_name":"Xu","full_name":"Xu, Tongda","first_name":"Tongda"},{"last_name":"Dai","first_name":"Ning","full_name":"Dai, Ning"},{"last_name":"Chen","full_name":"Chen, Jisheng","first_name":"Jisheng"},{"last_name":"Nagawa","first_name":"Shingo","full_name":"Nagawa, Shingo"},{"last_name":"Cao","full_name":"Cao, Min","first_name":"Min"},{"last_name":"Li","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5039-9660","first_name":"Hongjiang","full_name":"Li, Hongjiang"},{"first_name":"Zimin","full_name":"Zhou, Zimin","last_name":"Zhou"},{"id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87","last_name":"Chen","first_name":"Xu","full_name":"Chen, Xu"},{"last_name":"De Rycke","first_name":"Riet","full_name":"De Rycke, Riet"},{"full_name":"Rakusová, Hana","first_name":"Hana","last_name":"Rakusová"},{"full_name":"Wang, Wen","first_name":"Wen","last_name":"Wang"},{"last_name":"Jones","first_name":"Alan","full_name":"Jones, Alan"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jirí","full_name":"Friml, Jirí"},{"last_name":"Patterson","full_name":"Patterson, Sara","first_name":"Sara"},{"last_name":"Bleecker","full_name":"Bleecker, Anthony","first_name":"Anthony"},{"first_name":"Zhenbiao","full_name":"Yang, Zhenbiao","last_name":"Yang"}],"intvolume":"       343","type":"journal_article","publisher":"American Association for the Advancement of Science","department":[{"_id":"JiFr"}],"publication_status":"published","citation":{"apa":"Xu, T., Dai, N., Chen, J., Nagawa, S., Cao, M., Li, H., … Yang, Z. (2014). Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1245125\">https://doi.org/10.1126/science.1245125</a>","ieee":"T. Xu <i>et al.</i>, “Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling,” <i>Science</i>, vol. 343, no. 6174. American Association for the Advancement of Science, pp. 1025–1028, 2014.","ama":"Xu T, Dai N, Chen J, et al. Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling. <i>Science</i>. 2014;343(6174):1025-1028. doi:<a href=\"https://doi.org/10.1126/science.1245125\">10.1126/science.1245125</a>","short":"T. Xu, N. Dai, J. Chen, S. Nagawa, M. Cao, H. Li, Z. Zhou, X. Chen, R. De Rycke, H. Rakusová, W. Wang, A. Jones, J. Friml, S. Patterson, A. Bleecker, Z. Yang, Science 343 (2014) 1025–1028.","mla":"Xu, Tongda, et al. “Cell Surface ABP1-TMK Auxin Sensing Complex Activates ROP GTPase Signaling.” <i>Science</i>, vol. 343, no. 6174, American Association for the Advancement of Science, 2014, pp. 1025–28, doi:<a href=\"https://doi.org/10.1126/science.1245125\">10.1126/science.1245125</a>.","chicago":"Xu, Tongda, Ning Dai, Jisheng Chen, Shingo Nagawa, Min Cao, Hongjiang Li, Zimin Zhou, et al. “Cell Surface ABP1-TMK Auxin Sensing Complex Activates ROP GTPase Signaling.” <i>Science</i>. American Association for the Advancement of Science, 2014. <a href=\"https://doi.org/10.1126/science.1245125\">https://doi.org/10.1126/science.1245125</a>.","ista":"Xu T, Dai N, Chen J, Nagawa S, Cao M, Li H, Zhou Z, Chen X, De Rycke R, Rakusová H, Wang W, Jones A, Friml J, Patterson S, Bleecker A, Yang Z. 2014. Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling. Science. 343(6174), 1025–1028."},"date_created":"2018-12-11T11:54:42Z","_id":"1917","date_published":"2014-02-28T00:00:00Z","title":"Cell surface ABP1-TMK auxin sensing complex activates ROP GTPase signaling","external_id":{"pmid":["24578577"]},"quality_controlled":"1","scopus_import":1,"oa_version":"Submitted Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"5177","day":"28","pmid":1,"article_processing_charge":"No","year":"2014","language":[{"iso":"eng"}],"status":"public","month":"02","publication":"Science","doi":"10.1126/science.1245125","oa":1,"volume":343},{"oa_version":"Submitted Version","scopus_import":1,"quality_controlled":"1","month":"02","language":[{"iso":"eng"}],"year":"2014","status":"public","day":"01","publist_id":"5176","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","project":[{"name":"NSERC Postdoctoral fellowship","_id":"26450934-B435-11E9-9278-68D0E5697425"}],"doi":"10.1142/S0129055X13500219","publication":"Reviews in Mathematical Physics","volume":26,"oa":1,"main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1301.5370"}],"author":[{"last_name":"Bellazzini","full_name":"Bellazzini, Jacopo","first_name":"Jacopo"},{"last_name":"Frank","full_name":"Frank, Rupert","first_name":"Rupert"},{"full_name":"Lieb, Élliott","first_name":"Élliott","last_name":"Lieb"},{"orcid":"0000-0002-6781-0521","full_name":"Seiringer, Robert","first_name":"Robert","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87"}],"issue":"1","abstract":[{"text":"As the nuclear charge Z is continuously decreased an N-electron atom undergoes a binding-unbinding transition. We investigate whether the electrons remain bound and whether the radius of the system stays finite as the critical value Zc is approached. Existence of a ground state at Zc is shown under the condition Zc &lt; N-K, where K is the maximal number of electrons that can be removed at Zc without changing the energy.","lang":"eng"}],"article_number":"1350021","date_updated":"2021-01-12T06:54:04Z","type":"journal_article","intvolume":"        26","department":[{"_id":"RoSe"}],"publisher":"World Scientific Publishing","title":"Existence of ground states for negative ions at the binding threshold","date_published":"2014-02-01T00:00:00Z","_id":"1918","date_created":"2018-12-11T11:54:42Z","citation":{"ama":"Bellazzini J, Frank R, Lieb É, Seiringer R. Existence of ground states for negative ions at the binding threshold. <i>Reviews in Mathematical Physics</i>. 2014;26(1). doi:<a href=\"https://doi.org/10.1142/S0129055X13500219\">10.1142/S0129055X13500219</a>","ieee":"J. Bellazzini, R. Frank, É. Lieb, and R. Seiringer, “Existence of ground states for negative ions at the binding threshold,” <i>Reviews in Mathematical Physics</i>, vol. 26, no. 1. World Scientific Publishing, 2014.","apa":"Bellazzini, J., Frank, R., Lieb, É., &#38; Seiringer, R. (2014). Existence of ground states for negative ions at the binding threshold. <i>Reviews in Mathematical Physics</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/S0129055X13500219\">https://doi.org/10.1142/S0129055X13500219</a>","mla":"Bellazzini, Jacopo, et al. “Existence of Ground States for Negative Ions at the Binding Threshold.” <i>Reviews in Mathematical Physics</i>, vol. 26, no. 1, 1350021, World Scientific Publishing, 2014, doi:<a href=\"https://doi.org/10.1142/S0129055X13500219\">10.1142/S0129055X13500219</a>.","chicago":"Bellazzini, Jacopo, Rupert Frank, Élliott Lieb, and Robert Seiringer. “Existence of Ground States for Negative Ions at the Binding Threshold.” <i>Reviews in Mathematical Physics</i>. World Scientific Publishing, 2014. <a href=\"https://doi.org/10.1142/S0129055X13500219\">https://doi.org/10.1142/S0129055X13500219</a>.","short":"J. Bellazzini, R. Frank, É. Lieb, R. Seiringer, Reviews in Mathematical Physics 26 (2014).","ista":"Bellazzini J, Frank R, Lieb É, Seiringer R. 2014. Existence of ground states for negative ions at the binding threshold. Reviews in Mathematical Physics. 26(1), 1350021."},"publication_status":"published"},{"publication":"PNAS","department":[{"_id":"RySh"}],"doi":"10.1073/pnas.1303317110","publisher":"National Academy of Sciences","date_created":"2018-12-11T11:54:43Z","publication_status":"published","citation":{"short":"W. Aziz, W. Wang, S. Kesaf, A. Mohamed, Y. Fukazawa, R. Shigemoto, PNAS 111 (2014) E194–E202.","mla":"Aziz, Wajeeha, et al. “Distinct Kinetics of Synaptic Structural Plasticity, Memory Formation, and Memory Decay in Massed and Spaced Learning.” <i>PNAS</i>, vol. 111, no. 1, National Academy of Sciences, 2014, pp. E194–202, doi:<a href=\"https://doi.org/10.1073/pnas.1303317110\">10.1073/pnas.1303317110</a>.","chicago":"Aziz, Wajeeha, Wen Wang, Sebnem Kesaf, Alsayed Mohamed, Yugo Fukazawa, and Ryuichi Shigemoto. “Distinct Kinetics of Synaptic Structural Plasticity, Memory Formation, and Memory Decay in Massed and Spaced Learning.” <i>PNAS</i>. National Academy of Sciences, 2014. <a href=\"https://doi.org/10.1073/pnas.1303317110\">https://doi.org/10.1073/pnas.1303317110</a>.","apa":"Aziz, W., Wang, W., Kesaf, S., Mohamed, A., Fukazawa, Y., &#38; Shigemoto, R. (2014). Distinct kinetics of synaptic structural plasticity, memory formation, and memory decay in massed and spaced learning. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1303317110\">https://doi.org/10.1073/pnas.1303317110</a>","ieee":"W. Aziz, W. Wang, S. Kesaf, A. Mohamed, Y. Fukazawa, and R. Shigemoto, “Distinct kinetics of synaptic structural plasticity, memory formation, and memory decay in massed and spaced learning,” <i>PNAS</i>, vol. 111, no. 1. National Academy of Sciences, pp. E194–E202, 2014.","ama":"Aziz W, Wang W, Kesaf S, Mohamed A, Fukazawa Y, Shigemoto R. Distinct kinetics of synaptic structural plasticity, memory formation, and memory decay in massed and spaced learning. <i>PNAS</i>. 2014;111(1):E194-E202. doi:<a href=\"https://doi.org/10.1073/pnas.1303317110\">10.1073/pnas.1303317110</a>","ista":"Aziz W, Wang W, Kesaf S, Mohamed A, Fukazawa Y, Shigemoto R. 2014. Distinct kinetics of synaptic structural plasticity, memory formation, and memory decay in massed and spaced learning. PNAS. 111(1), E194–E202."},"volume":111,"title":"Distinct kinetics of synaptic structural plasticity, memory formation, and memory decay in massed and spaced learning","oa":1,"date_published":"2014-01-07T00:00:00Z","_id":"1919","page":"E194 - E202","abstract":[{"text":"Long-lasting memories are formed when the stimulus is temporally distributed (spacing effect). However, the synaptic mechanisms underlying this robust phenomenon and the precise time course of the synaptic modifications that occur during learning remain unclear. Here we examined the adaptation of horizontal optokinetic response in mice that underwent 1 h of massed and spaced training at varying intervals. Despite similar acquisition by all training protocols, 1 h of spacing produced the highest memory retention at 24 h, which lasted for 1 mo. The distinct kinetics of memory are strongly correlated with the reduction of floccular parallel fiber-Purkinje cell synapses but not with AMPA receptor (AMPAR) number and synapse size. After the spaced training, we observed 25%, 23%, and 12% reduction in AMPAR density, synapse size, and synapse number, respectively. Four hours after the spaced training, half of the synapses and Purkinje cell spines had been eliminated, whereas AMPAR density and synapse size were recovered in remaining synapses. Surprisingly, massed training also produced long-term memory and halving of synapses; however, this occurred slowly over days, and the memory lasted for only 1 wk. This distinct kinetics of structural plasticity may serve as a basis for unique temporal profiles in the formation and decay of memory with or without intervals.","lang":"eng"}],"date_updated":"2021-01-12T06:54:04Z","author":[{"last_name":"Aziz","first_name":"Wajeeha","full_name":"Aziz, Wajeeha"},{"last_name":"Wang","first_name":"Wen","full_name":"Wang, Wen"},{"first_name":"Sebnem","full_name":"Kesaf, Sebnem","id":"401AB46C-F248-11E8-B48F-1D18A9856A87","last_name":"Kesaf"},{"full_name":"Mohamed, Alsayed","first_name":"Alsayed","last_name":"Mohamed"},{"last_name":"Fukazawa","first_name":"Yugo","full_name":"Fukazawa, Yugo"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","orcid":"0000-0001-8761-9444"}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890840/"}],"oa_version":"Submitted Version","acknowledgement":"his work was supported by Solution Oriented Research for Science and Technology (R.S.), Core Research for Evolutional Science and Technology, Japan Science and Technology Agency (Y.F.), and Grants-in-Aid for Scientific Research on Priority Areas-Molecular Brain Sciences 16300114 (to R.S.) and 18022043 (to Y.F.).","scopus_import":1,"issue":"1","day":"07","publist_id":"5175","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","month":"01","status":"public","year":"2014","intvolume":"       111","language":[{"iso":"eng"}],"type":"journal_article"},{"publication":"PNAS","department":[{"_id":"RySh"}],"doi":"10.1073/pnas.1315541111","publisher":"National Academy of Sciences","date_created":"2018-12-11T11:54:43Z","publication_status":"published","citation":{"apa":"Wang, W., Nakadate, K., Masugi Tokita, M., Shutoh, F., Aziz, W., Tarusawa, E., … Shigemoto, R. (2014). Distinct cerebellar engrams in short-term and long-term motor learning. <i>PNAS</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1315541111\">https://doi.org/10.1073/pnas.1315541111</a>","ama":"Wang W, Nakadate K, Masugi Tokita M, et al. Distinct cerebellar engrams in short-term and long-term motor learning. <i>PNAS</i>. 2014;111(1):E188-E193. doi:<a href=\"https://doi.org/10.1073/pnas.1315541111\">10.1073/pnas.1315541111</a>","ieee":"W. Wang <i>et al.</i>, “Distinct cerebellar engrams in short-term and long-term motor learning,” <i>PNAS</i>, vol. 111, no. 1. National Academy of Sciences, pp. E188–E193, 2014.","short":"W. Wang, K. Nakadate, M. Masugi Tokita, F. Shutoh, W. Aziz, E. Tarusawa, A. Lörincz, E. Molnár, S. Kesaf, Y. Li, Y. Fukazawa, S. Nagao, R. Shigemoto, PNAS 111 (2014) E188–E193.","mla":"Wang, Wen, et al. “Distinct Cerebellar Engrams in Short-Term and Long-Term Motor Learning.” <i>PNAS</i>, vol. 111, no. 1, National Academy of Sciences, 2014, pp. E188–93, doi:<a href=\"https://doi.org/10.1073/pnas.1315541111\">10.1073/pnas.1315541111</a>.","chicago":"Wang, Wen, Kazuhiko Nakadate, Miwako Masugi Tokita, Fumihiro Shutoh, Wajeeha Aziz, Etsuko Tarusawa, Andrea Lörincz, et al. “Distinct Cerebellar Engrams in Short-Term and Long-Term Motor Learning.” <i>PNAS</i>. National Academy of Sciences, 2014. <a href=\"https://doi.org/10.1073/pnas.1315541111\">https://doi.org/10.1073/pnas.1315541111</a>.","ista":"Wang W, Nakadate K, Masugi Tokita M, Shutoh F, Aziz W, Tarusawa E, Lörincz A, Molnár E, Kesaf S, Li Y, Fukazawa Y, Nagao S, Shigemoto R. 2014. Distinct cerebellar engrams in short-term and long-term motor learning. PNAS. 111(1), E188–E193."},"date_published":"2014-01-07T00:00:00Z","_id":"1920","volume":111,"title":"Distinct cerebellar engrams in short-term and long-term motor learning","oa":1,"date_updated":"2021-01-12T06:54:05Z","abstract":[{"text":"Cerebellar motor learning is suggested to be caused by long-term plasticity of excitatory parallel fiber-Purkinje cell (PF-PC) synapses associated with changes in the number of synaptic AMPA-type glutamate receptors (AMPARs). However, whether the AMPARs decrease or increase in individual PF-PC synapses occurs in physiological motor learning and accounts for memory that lasts over days remains elusive. We combined quantitative SDS-digested freeze-fracture replica labeling for AMPAR and physical dissector electron microscopy with a simple model of cerebellar motor learning, adaptation of horizontal optokinetic response (HOKR) in mouse. After 1-h training of HOKR, short-term adaptation (STA) was accompanied with transient decrease in AMPARs by 28% in target PF-PC synapses. STA was well correlated with AMPAR decrease in individual animals and both STA and AMPAR decrease recovered to basal levels within 24 h. Surprisingly, long-termadaptation (LTA) after five consecutive daily trainings of 1-h HOKR did not alter the number of AMPARs in PF-PC synapses but caused gradual and persistent synapse elimination by 45%, with corresponding PC spine loss by the fifth training day. Furthermore, recovery of LTA after 2 wk was well correlated with increase of PF-PC synapses to the control level. Our findings indicate that the AMPARs decrease in PF-PC synapses and the elimination of these synapses are in vivo engrams in short- and long-term motor learning, respectively, showing a unique type of synaptic plasticity that may contribute to memory consolidation.","lang":"eng"}],"page":"E188 - E193","scopus_import":1,"issue":"1","author":[{"first_name":"Wen","full_name":"Wang, Wen","last_name":"Wang"},{"first_name":"Kazuhiko","full_name":"Nakadate, Kazuhiko","last_name":"Nakadate"},{"last_name":"Masugi Tokita","first_name":"Miwako","full_name":"Masugi Tokita, Miwako"},{"first_name":"Fumihiro","full_name":"Shutoh, Fumihiro","last_name":"Shutoh"},{"full_name":"Aziz, Wajeeha","first_name":"Wajeeha","last_name":"Aziz"},{"first_name":"Etsuko","full_name":"Tarusawa, Etsuko","last_name":"Tarusawa"},{"last_name":"Lörincz","first_name":"Andrea","full_name":"Lörincz, Andrea"},{"last_name":"Molnár","first_name":"Elek","full_name":"Molnár, Elek"},{"id":"401AB46C-F248-11E8-B48F-1D18A9856A87","last_name":"Kesaf","full_name":"Kesaf, Sebnem","first_name":"Sebnem"},{"first_name":"Yunqing","full_name":"Li, Yunqing","last_name":"Li"},{"last_name":"Fukazawa","full_name":"Fukazawa, Yugo","first_name":"Yugo"},{"last_name":"Nagao","full_name":"Nagao, Soichi","first_name":"Soichi"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"}],"oa_version":"Submitted Version","acknowledgement":"This work was supported by Solution-Oriented Research for Science and Technology from the Japan Science and Technology Agency; Ministry of Education, Culture, Sports, Science and Technology of Japan Grant 16300114 (to R.S.).","main_file_link":[{"url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890858/","open_access":"1"}],"publist_id":"5174","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","day":"07","intvolume":"       111","year":"2014","language":[{"iso":"eng"}],"type":"journal_article","status":"public","month":"01"},{"scopus_import":1,"oa_version":"Submitted Version","status":"public","language":[{"iso":"eng"}],"year":"2014","month":"05","publist_id":"5173","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","day":"01","project":[{"call_identifier":"FP7","grant_number":"282300","_id":"25716A02-B435-11E9-9278-68D0E5697425","name":"Polarity and subcellular dynamics in plants"}],"doi":"10.1105/tpc.114.126185","publication":"Plant Cell","volume":26,"oa":1,"issue":"5","author":[{"last_name":"Tejos","first_name":"Ricardo","full_name":"Tejos, Ricardo"},{"first_name":"Michael","full_name":"Sauer, Michael","last_name":"Sauer"},{"last_name":"Vanneste","first_name":"Steffen","full_name":"Vanneste, Steffen"},{"last_name":"Palacios-Gomez","first_name":"MiriamPalacios ","full_name":"Palacios-Gomez, MiriamPalacios "},{"last_name":"Li","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5039-9660","full_name":"Li, Hongjiang","first_name":"Hongjiang"},{"first_name":"Mareike","full_name":"Heilmann, Mareike","last_name":"Heilmann"},{"first_name":"Ringo","full_name":"Van Wijk, Ringo","last_name":"Van Wijk"},{"full_name":"Vermeer, Joop","first_name":"Joop","last_name":"Vermeer"},{"first_name":"Ingo","full_name":"Heilmann, Ingo","last_name":"Heilmann"},{"last_name":"Munnik","full_name":"Munnik, Teun","first_name":"Teun"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","full_name":"Friml, Jirí","first_name":"Jirí","orcid":"0000-0002-8302-7596"}],"acknowledgement":"This work was supported by grants from the Odysseus program of the Research Foundation-Flanders (to J.F.).","main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4079372/"}],"date_updated":"2021-01-12T06:54:05Z","page":"2114 - 2128","abstract":[{"lang":"eng","text":"Cell polarity manifested by asymmetric distribution of cargoes, such as receptors and transporters, within the plasma membrane (PM) is crucial for essential functions in multicellular organisms. In plants, cell polarity (re)establishment is intimately linked to patterning processes. Despite the importance of cell polarity, its underlying mechanisms are still largely unknown, including the definition and distinctiveness of the polar domains within the PM. Here, we show in Arabidopsis thaliana that the signaling membrane components, the phosphoinositides phosphatidylinositol 4-phosphate (PtdIns4P) and phosphatidylinositol 4, 5-bisphosphate [PtdIns(4, 5)P2] as well as PtdIns4P 5-kinases mediating their interconversion, are specifically enriched at apical and basal polar plasma membrane domains. The PtdIns4P 5-kinases PIP5K1 and PIP5K2 are redundantly required for polar localization of specifically apical and basal cargoes, such as PIN-FORMED transporters for the plant hormone auxin. As a consequence of the polarity defects, instructive auxin gradients as well as embryonic and postembryonic patterning are severely compromised. Furthermore, auxin itself regulates PIP5K transcription and PtdIns4P and PtdIns(4, 5)P2 levels, in particular their association with polar PM domains. Our results provide insight into the polar domain-delineating mechanisms in plant cells that depend on apical and basal distribution of membrane lipids and are essential for embryonic and postembryonic patterning."}],"intvolume":"        26","type":"journal_article","department":[{"_id":"JiFr"}],"publisher":"American Society of Plant Biologists","date_published":"2014-05-01T00:00:00Z","_id":"1921","title":"Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis","ec_funded":1,"date_created":"2018-12-11T11:54:43Z","publication_status":"published","citation":{"ista":"Tejos R, Sauer M, Vanneste S, Palacios-Gomez M, Li H, Heilmann M, Van Wijk R, Vermeer J, Heilmann I, Munnik T, Friml J. 2014. Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis. Plant Cell. 26(5), 2114–2128.","short":"R. Tejos, M. Sauer, S. Vanneste, M. Palacios-Gomez, H. Li, M. Heilmann, R. Van Wijk, J. Vermeer, I. Heilmann, T. Munnik, J. Friml, Plant Cell 26 (2014) 2114–2128.","mla":"Tejos, Ricardo, et al. “Bipolar Plasma Membrane Distribution of Phosphoinositides and Their Requirement for Auxin-Mediated Cell Polarity and Patterning in Arabidopsis.” <i>Plant Cell</i>, vol. 26, no. 5, American Society of Plant Biologists, 2014, pp. 2114–28, doi:<a href=\"https://doi.org/10.1105/tpc.114.126185\">10.1105/tpc.114.126185</a>.","chicago":"Tejos, Ricardo, Michael Sauer, Steffen Vanneste, MiriamPalacios  Palacios-Gomez, Hongjiang Li, Mareike Heilmann, Ringo Van Wijk, et al. “Bipolar Plasma Membrane Distribution of Phosphoinositides and Their Requirement for Auxin-Mediated Cell Polarity and Patterning in Arabidopsis.” <i>Plant Cell</i>. American Society of Plant Biologists, 2014. <a href=\"https://doi.org/10.1105/tpc.114.126185\">https://doi.org/10.1105/tpc.114.126185</a>.","apa":"Tejos, R., Sauer, M., Vanneste, S., Palacios-Gomez, M., Li, H., Heilmann, M., … Friml, J. (2014). Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis. <i>Plant Cell</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1105/tpc.114.126185\">https://doi.org/10.1105/tpc.114.126185</a>","ieee":"R. Tejos <i>et al.</i>, “Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis,” <i>Plant Cell</i>, vol. 26, no. 5. American Society of Plant Biologists, pp. 2114–2128, 2014.","ama":"Tejos R, Sauer M, Vanneste S, et al. Bipolar plasma membrane distribution of phosphoinositides and their requirement for auxin-mediated cell polarity and patterning in Arabidopsis. <i>Plant Cell</i>. 2014;26(5):2114-2128. doi:<a href=\"https://doi.org/10.1105/tpc.114.126185\">10.1105/tpc.114.126185</a>"}},{"author":[{"first_name":"Hélène","full_name":"Berthoumieux, Hélène","last_name":"Berthoumieux"},{"orcid":"0000-0002-3688-1474","first_name":"Jean-Léon","full_name":"Maître, Jean-Léon","id":"48F1E0D8-F248-11E8-B48F-1D18A9856A87","last_name":"Maître"},{"orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg"},{"full_name":"Paluch, Ewa","first_name":"Ewa","last_name":"Paluch"},{"last_name":"Julicher","first_name":"Frank","full_name":"Julicher, Frank"},{"last_name":"Salbreux","full_name":"Salbreux, Guillaume","first_name":"Guillaume"}],"file_date_updated":"2020-07-14T12:45:21Z","abstract":[{"lang":"eng","text":"We derive the equations for a thin, axisymmetric elastic shell subjected to an internal active stress giving rise to active tension and moments within the shell. We discuss the stability of a cylindrical elastic shell and its response to a localized change in internal active stress. This description is relevant to describe the cellular actomyosin cortex, a thin shell at the cell surface behaving elastically at a short timescale and subjected to active internal forces arising from myosin molecular motor activity. We show that the recent observations of cell deformation following detachment of adherent cells (Maître J-L et al 2012 Science 338 253-6) are well accounted for by this mechanical description. The actin cortex elastic and bending moduli can be obtained from a quantitative analysis of cell shapes observed in these experiments. Our approach thus provides a non-invasive, imaging-based method for the extraction of cellular physical parameters."}],"article_number":"065005","date_updated":"2021-01-12T06:54:06Z","type":"journal_article","intvolume":"        16","ddc":["570"],"department":[{"_id":"CaHe"}],"publisher":"IOP Publishing Ltd.","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"file":[{"file_size":941387,"file_id":"5202","creator":"system","checksum":"8dbe81ec656bf1264d8889bda9b2b985","date_updated":"2020-07-14T12:45:21Z","access_level":"open_access","relation":"main_file","content_type":"application/pdf","file_name":"IST-2016-429-v1+1_document.pdf","date_created":"2018-12-12T10:16:16Z"}],"title":"Active elastic thin shell theory for cellular deformations","_id":"1923","date_published":"2014-06-01T00:00:00Z","date_created":"2018-12-11T11:54:44Z","publication_status":"published","citation":{"ista":"Berthoumieux H, Maître J-L, Heisenberg C-PJ, Paluch E, Julicher F, Salbreux G. 2014. Active elastic thin shell theory for cellular deformations. New Journal of Physics. 16, 065005.","ieee":"H. Berthoumieux, J.-L. Maître, C.-P. J. Heisenberg, E. Paluch, F. Julicher, and G. Salbreux, “Active elastic thin shell theory for cellular deformations,” <i>New Journal of Physics</i>, vol. 16. IOP Publishing Ltd., 2014.","ama":"Berthoumieux H, Maître J-L, Heisenberg C-PJ, Paluch E, Julicher F, Salbreux G. Active elastic thin shell theory for cellular deformations. <i>New Journal of Physics</i>. 2014;16. doi:<a href=\"https://doi.org/10.1088/1367-2630/16/6/065005\">10.1088/1367-2630/16/6/065005</a>","apa":"Berthoumieux, H., Maître, J.-L., Heisenberg, C.-P. J., Paluch, E., Julicher, F., &#38; Salbreux, G. (2014). Active elastic thin shell theory for cellular deformations. <i>New Journal of Physics</i>. IOP Publishing Ltd. <a href=\"https://doi.org/10.1088/1367-2630/16/6/065005\">https://doi.org/10.1088/1367-2630/16/6/065005</a>","chicago":"Berthoumieux, Hélène, Jean-Léon Maître, Carl-Philipp J Heisenberg, Ewa Paluch, Frank Julicher, and Guillaume Salbreux. “Active Elastic Thin Shell Theory for Cellular Deformations.” <i>New Journal of Physics</i>. IOP Publishing Ltd., 2014. <a href=\"https://doi.org/10.1088/1367-2630/16/6/065005\">https://doi.org/10.1088/1367-2630/16/6/065005</a>.","mla":"Berthoumieux, Hélène, et al. “Active Elastic Thin Shell Theory for Cellular Deformations.” <i>New Journal of Physics</i>, vol. 16, 065005, IOP Publishing Ltd., 2014, doi:<a href=\"https://doi.org/10.1088/1367-2630/16/6/065005\">10.1088/1367-2630/16/6/065005</a>.","short":"H. Berthoumieux, J.-L. Maître, C.-P.J. Heisenberg, E. Paluch, F. Julicher, G. Salbreux, New Journal of Physics 16 (2014)."},"oa_version":"Published Version","scopus_import":1,"quality_controlled":"1","has_accepted_license":"1","month":"06","status":"public","year":"2014","language":[{"iso":"eng"}],"day":"01","publist_id":"5171","pubrep_id":"429","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","doi":"10.1088/1367-2630/16/6/065005","publication":"New Journal of Physics","volume":16,"oa":1},{"doi":"10.1088/0957-4484/25/12/125704","publication":"Nanotechnology","oa":1,"volume":25,"scopus_import":1,"oa_version":"Submitted Version","has_accepted_license":"1","article_processing_charge":"No","language":[{"iso":"eng"}],"year":"2014","status":"public","month":"03","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"5169","day":"28","publisher":"IOP Publishing","department":[{"_id":"CaHe"},{"_id":"MiSi"}],"file":[{"file_name":"2014_Nanotechnology_Lamprecht.pdf","date_created":"2020-05-15T09:21:19Z","content_type":"application/pdf","checksum":"df4e03d225a19179e7790f6d87a12332","date_updated":"2020-07-14T12:45:21Z","relation":"main_file","access_level":"open_access","creator":"dernst","file_id":"7856","file_size":3804152}],"date_published":"2014-03-28T00:00:00Z","_id":"1925","title":"A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes","citation":{"apa":"Lamprecht, C., Plochberger, B., Ruprecht, V., Wieser, S., Rankl, C., Heister, E., … Ebner, A. (2014). A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. <i>Nanotechnology</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">https://doi.org/10.1088/0957-4484/25/12/125704</a>","ama":"Lamprecht C, Plochberger B, Ruprecht V, et al. A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. <i>Nanotechnology</i>. 2014;25(12). doi:<a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">10.1088/0957-4484/25/12/125704</a>","ieee":"C. Lamprecht <i>et al.</i>, “A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes,” <i>Nanotechnology</i>, vol. 25, no. 12. IOP Publishing, 2014.","short":"C. Lamprecht, B. Plochberger, V. Ruprecht, S. Wieser, C. Rankl, E. Heister, B. Unterauer, M. Brameshuber, J. Danzberger, P. Lukanov, E. Flahaut, G. Schütz, P. Hinterdorfer, A. Ebner, Nanotechnology 25 (2014).","chicago":"Lamprecht, Constanze, Birgit Plochberger, Verena Ruprecht, Stefan Wieser, Christian Rankl, Elena Heister, Barbara Unterauer, et al. “A Single-Molecule Approach to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” <i>Nanotechnology</i>. IOP Publishing, 2014. <a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">https://doi.org/10.1088/0957-4484/25/12/125704</a>.","mla":"Lamprecht, Constanze, et al. “A Single-Molecule Approach to Explore Binding Uptake and Transport of Cancer Cell Targeting Nanotubes.” <i>Nanotechnology</i>, vol. 25, no. 12, 125704, IOP Publishing, 2014, doi:<a href=\"https://doi.org/10.1088/0957-4484/25/12/125704\">10.1088/0957-4484/25/12/125704</a>.","ista":"Lamprecht C, Plochberger B, Ruprecht V, Wieser S, Rankl C, Heister E, Unterauer B, Brameshuber M, Danzberger J, Lukanov P, Flahaut E, Schütz G, Hinterdorfer P, Ebner A. 2014. A single-molecule approach to explore binding uptake and transport of cancer cell targeting nanotubes. Nanotechnology. 25(12), 125704."},"publication_status":"published","date_created":"2018-12-11T11:54:45Z","issue":"12","file_date_updated":"2020-07-14T12:45:21Z","acknowledgement":"This work was supported by EC grant Marie Curie RTN-CT-2006-035616, CARBIO 'Carbon nanotubes for biomedical applications' and Austrian FFG grant mnt-era.net 823980, 'IntelliTip'.\r\n","author":[{"first_name":"Constanze","full_name":"Lamprecht, Constanze","last_name":"Lamprecht"},{"full_name":"Plochberger, Birgit","first_name":"Birgit","last_name":"Plochberger"},{"orcid":"0000-0003-4088-8633","full_name":"Ruprecht, Verena","first_name":"Verena","id":"4D71A03A-F248-11E8-B48F-1D18A9856A87","last_name":"Ruprecht"},{"full_name":"Wieser, Stefan","first_name":"Stefan","orcid":"0000-0002-2670-2217","id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","last_name":"Wieser"},{"last_name":"Rankl","first_name":"Christian","full_name":"Rankl, Christian"},{"first_name":"Elena","full_name":"Heister, Elena","last_name":"Heister"},{"last_name":"Unterauer","first_name":"Barbara","full_name":"Unterauer, Barbara"},{"full_name":"Brameshuber, Mario","first_name":"Mario","last_name":"Brameshuber"},{"last_name":"Danzberger","first_name":"Jürgen","full_name":"Danzberger, Jürgen"},{"last_name":"Lukanov","full_name":"Lukanov, Petar","first_name":"Petar"},{"last_name":"Flahaut","full_name":"Flahaut, Emmanuel","first_name":"Emmanuel"},{"last_name":"Schütz","full_name":"Schütz, Gerhard","first_name":"Gerhard"},{"last_name":"Hinterdorfer","full_name":"Hinterdorfer, Peter","first_name":"Peter"},{"first_name":"Andreas","full_name":"Ebner, Andreas","last_name":"Ebner"}],"date_updated":"2021-01-12T06:54:07Z","article_type":"original","abstract":[{"lang":"eng","text":"In the past decade carbon nanotubes (CNTs) have been widely studied as a potential drug-delivery system, especially with functionality for cellular targeting. Yet, little is known about the actual process of docking to cell receptors and transport dynamics after internalization. Here we performed single-particle studies of folic acid (FA) mediated CNT binding to human carcinoma cells and their transport inside the cytosol. In particular, we employed molecular recognition force spectroscopy, an atomic force microscopy based method, to visualize and quantify docking of FA functionalized CNTs to FA binding receptors in terms of binding probability and binding force. We then traced individual fluorescently labeled, FA functionalized CNTs after specific uptake, and created a dynamic 'roadmap' that clearly showed trajectories of directed diffusion and areas of nanotube confinement in the cytosol. Our results demonstrate the potential of a single-molecule approach for investigation of drug-delivery vehicles and their targeting capacity."}],"article_number":"125704","intvolume":"        25","type":"journal_article","ddc":["570"]},{"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1304.3862"}],"author":[{"orcid":"0000-0001-8255-3968","first_name":"Christian","full_name":"Sadel, Christian","last_name":"Sadel","id":"4760E9F8-F248-11E8-B48F-1D18A9856A87"}],"issue":"3-4","page":"409 - 440","article_type":"original","abstract":[{"lang":"eng","text":"We consider cross products of finite graphs with a class of trees that have arbitrarily but finitely long line segments, such as the Fibonacci tree. Such cross products are called tree-strips. We prove that for small disorder random Schrödinger operators on such tree-strips have purely absolutely continuous spectrum in a certain set."}],"date_updated":"2021-01-12T06:54:07Z","type":"journal_article","intvolume":"        17","department":[{"_id":"LaEr"}],"publisher":"Springer","title":"Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips","ec_funded":1,"date_published":"2014-12-17T00:00:00Z","_id":"1926","date_created":"2018-12-11T11:54:45Z","citation":{"ieee":"C. Sadel, “Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips,” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 17, no. 3–4. Springer, pp. 409–440, 2014.","ama":"Sadel C. Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips. <i>Mathematical Physics, Analysis and Geometry</i>. 2014;17(3-4):409-440. doi:<a href=\"https://doi.org/10.1007/s11040-014-9163-4\">10.1007/s11040-014-9163-4</a>","apa":"Sadel, C. (2014). Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips. <i>Mathematical Physics, Analysis and Geometry</i>. Springer. <a href=\"https://doi.org/10.1007/s11040-014-9163-4\">https://doi.org/10.1007/s11040-014-9163-4</a>","mla":"Sadel, Christian. “Absolutely Continuous Spectrum for Random Schrödinger Operators on the Fibonacci and Similar Tree-Strips.” <i>Mathematical Physics, Analysis and Geometry</i>, vol. 17, no. 3–4, Springer, 2014, pp. 409–40, doi:<a href=\"https://doi.org/10.1007/s11040-014-9163-4\">10.1007/s11040-014-9163-4</a>.","chicago":"Sadel, Christian. “Absolutely Continuous Spectrum for Random Schrödinger Operators on the Fibonacci and Similar Tree-Strips.” <i>Mathematical Physics, Analysis and Geometry</i>. Springer, 2014. <a href=\"https://doi.org/10.1007/s11040-014-9163-4\">https://doi.org/10.1007/s11040-014-9163-4</a>.","short":"C. Sadel, Mathematical Physics, Analysis and Geometry 17 (2014) 409–440.","ista":"Sadel C. 2014. Absolutely continuous spectrum for random Schrödinger operators on the Fibonacci and similar Tree-strips. Mathematical Physics, Analysis and Geometry. 17(3–4), 409–440."},"publication_status":"published","oa_version":"Preprint","scopus_import":1,"quality_controlled":"1","external_id":{"arxiv":["1304.3862"]},"month":"12","status":"public","language":[{"iso":"eng"}],"year":"2014","article_processing_charge":"No","day":"17","publist_id":"5168","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"name":"NSERC Postdoctoral fellowship","_id":"26450934-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"}],"doi":"10.1007/s11040-014-9163-4","arxiv":1,"publication":"Mathematical Physics, Analysis and Geometry","volume":17,"oa":1},{"publisher":"Springer","doi":"10.1145/2591796.2591825","volume":8874,"title":"Adaptive security of constrained PRFs","oa":1,"_id":"1927","extern":1,"date_published":"2014-01-01T00:00:00Z","date_created":"2018-12-11T11:54:45Z","publication_status":"published","citation":{"apa":"Fuchsbauer, G., Konstantinov, M., Pietrzak, K. Z., &#38; Rao, V. (2014). Adaptive security of constrained PRFs (Vol. 8874, pp. 173–192). Presented at the Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), Springer. <a href=\"https://doi.org/10.1145/2591796.2591825\">https://doi.org/10.1145/2591796.2591825</a>","ama":"Fuchsbauer G, Konstantinov M, Pietrzak KZ, Rao V. Adaptive security of constrained PRFs. In: Vol 8874. Springer; 2014:173-192. doi:<a href=\"https://doi.org/10.1145/2591796.2591825\">10.1145/2591796.2591825</a>","ieee":"G. Fuchsbauer, M. Konstantinov, K. Z. Pietrzak, and V. Rao, “Adaptive security of constrained PRFs,” presented at the Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 2014, vol. 8874, pp. 173–192.","short":"G. Fuchsbauer, M. Konstantinov, K.Z. Pietrzak, V. Rao, in:, Springer, 2014, pp. 173–192.","mla":"Fuchsbauer, Georg, et al. <i>Adaptive Security of Constrained PRFs</i>. Vol. 8874, Springer, 2014, pp. 173–92, doi:<a href=\"https://doi.org/10.1145/2591796.2591825\">10.1145/2591796.2591825</a>.","chicago":"Fuchsbauer, Georg, Momchil Konstantinov, Krzysztof Z Pietrzak, and Vanishree Rao. “Adaptive Security of Constrained PRFs,” 8874:173–92. Springer, 2014. <a href=\"https://doi.org/10.1145/2591796.2591825\">https://doi.org/10.1145/2591796.2591825</a>.","ista":"Fuchsbauer G, Konstantinov M, Pietrzak KZ, Rao V. 2014. Adaptive security of constrained PRFs. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) vol. 8874, 173–192."},"main_file_link":[{"url":"http://eprint.iacr.org/2014/416","open_access":"1"}],"acknowledgement":"We are grateful to Mihir Bellare for his feedback on earlier versions of this paper. We are indebted to Vanishree Rao for her generous assistance in preparing this proceedings version.","author":[{"full_name":"Georg Fuchsbauer","first_name":"Georg","last_name":"Fuchsbauer","id":"46B4C3EE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Konstantinov","full_name":"Konstantinov, Momchil","first_name":"Momchil"},{"id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","last_name":"Pietrzak","orcid":"0000-0002-9139-1654","full_name":"Krzysztof Pietrzak","first_name":"Krzysztof Z"},{"full_name":"Rao, Vanishree","first_name":"Vanishree","last_name":"Rao"}],"abstract":[{"lang":"eng","text":"Constrained pseudorandom functions have recently been introduced independently by Boneh and Waters (Asiacrypt’13), Kiayias et al. (CCS’13), and Boyle et al. (PKC’14). In a standard pseudorandom function (PRF) a key k is used to evaluate the PRF on all inputs in the domain. Constrained PRFs additionally offer the functionality to delegate “constrained” keys kS which allow to evaluate the PRF only on a subset S of the domain. The three above-mentioned papers all show that the classical GGM construction (J.ACM’86) of a PRF from a pseudorandom generator (PRG) directly yields a constrained PRF where one can compute constrained keys to evaluate the PRF on all inputs with a given prefix. This constrained PRF has already found many interesting applications. Unfortunately, the existing security proofs only show selective security (by a reduction to the security of the underlying PRG). To achieve full security, one has to use complexity leveraging, which loses an exponential factor 2N in security, where N is the input length. The first contribution of this paper is a new reduction that only loses a quasipolynomial factor qlog N, where q is the number of adversarial queries. For this we develop a new proof technique which constructs a distinguisher by interleaving simple guessing steps and hybrid arguments a small number of times. This approach might be of interest also in other contexts where currently the only technique to achieve full security is complexity leveraging. Our second contribution is concerned with another constrained PRF, due to Boneh and Waters, which allows for constrained keys for the more general class of bit-fixing functions. Their security proof also suffers from a 2N loss, which we show is inherent. We construct a meta-reduction which shows that any “simple” reduction of full security from a noninteractive hardness assumption must incur an exponential security loss."}],"page":"173 - 192","quality_controlled":0,"conference":{"name":"Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)"},"date_updated":"2021-01-12T06:54:08Z","month":"01","type":"conference","year":"2014","intvolume":"      8874","status":"public","day":"01","publist_id":"5167"}]