[{"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Springer","department":[{"_id":"ToHe"}],"ec_funded":1,"scopus_import":1,"author":[{"full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","orcid":"0000−0002−2985−7724","last_name":"Henzinger","first_name":"Thomas A"},{"full_name":"Otop, Jan","id":"2FC5DA74-F248-11E8-B48F-1D18A9856A87","last_name":"Otop","first_name":"Jan"},{"first_name":"Roopsha","last_name":"Samanta","full_name":"Samanta, Roopsha","id":"3D2AAC08-F248-11E8-B48F-1D18A9856A87"}],"day":"01","title":"Lipschitz robustness of timed I/O systems","publist_id":"5647","project":[{"_id":"25EE3708-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Quantitative Reactive Modeling","grant_number":"267989"},{"call_identifier":"FWF","_id":"25F42A32-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize","grant_number":"Z211"},{"grant_number":"S 11407_N23","call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering"}],"conference":{"end_date":"2016-01-19","start_date":"2016-01-17","name":"VMCAI: Verification, Model Checking and Abstract Interpretation","location":"St. Petersburg, FL, USA"},"language":[{"iso":"eng"}],"doi":"10.1007/978-3-662-49122-5_12","quality_controlled":"1","acknowledgement":"This research was supported in part by the European Research Council (ERC) under grant 267989 (QUAREM), by the Austrian Science Fund (FWF) under grants S11402-N23 (RiSE) and Z211-N23 (Wittgenstein Award), and by the National Science Centre (NCN), Poland under grant 2014/15/D/ST6/04543.","year":"2016","_id":"1526","page":"250 - 267","type":"conference","oa_version":"Preprint","month":"01","abstract":[{"lang":"eng","text":"We present the first study of robustness of systems that are both timed as well as reactive (I/O). We study the behavior of such timed I/O systems in the presence of uncertain inputs and formalize their robustness using the analytic notion of Lipschitz continuity: a timed I/O system is K-(Lipschitz) robust if the perturbation in its output is at most K times the perturbation in its input. We quantify input and output perturbation using similarity functions over timed words such as the timed version of the Manhattan distance and the Skorokhod distance. We consider two models of timed I/O systems — timed transducers and asynchronous sequential circuits. We show that K-robustness of timed transducers can be decided in polynomial space under certain conditions. For asynchronous sequential circuits, we reduce K-robustness w.r.t. timed Manhattan distances to K-robustness of discrete letter-to-letter transducers and show PSpace-completeness of the problem."}],"date_updated":"2021-01-12T06:51:23Z","volume":9583,"date_created":"2018-12-11T11:52:32Z","alternative_title":["LNCS"],"status":"public","intvolume":"      9583","citation":{"apa":"Henzinger, T. A., Otop, J., &#38; Samanta, R. (2016). Lipschitz robustness of timed I/O systems (Vol. 9583, pp. 250–267). Presented at the VMCAI: Verification, Model Checking and Abstract Interpretation, St. Petersburg, FL, USA: Springer. <a href=\"https://doi.org/10.1007/978-3-662-49122-5_12\">https://doi.org/10.1007/978-3-662-49122-5_12</a>","ista":"Henzinger TA, Otop J, Samanta R. 2016. Lipschitz robustness of timed I/O systems. VMCAI: Verification, Model Checking and Abstract Interpretation, LNCS, vol. 9583, 250–267.","mla":"Henzinger, Thomas A., et al. <i>Lipschitz Robustness of Timed I/O Systems</i>. Vol. 9583, Springer, 2016, pp. 250–67, doi:<a href=\"https://doi.org/10.1007/978-3-662-49122-5_12\">10.1007/978-3-662-49122-5_12</a>.","ama":"Henzinger TA, Otop J, Samanta R. Lipschitz robustness of timed I/O systems. In: Vol 9583. Springer; 2016:250-267. doi:<a href=\"https://doi.org/10.1007/978-3-662-49122-5_12\">10.1007/978-3-662-49122-5_12</a>","short":"T.A. Henzinger, J. Otop, R. Samanta, in:, Springer, 2016, pp. 250–267.","chicago":"Henzinger, Thomas A, Jan Otop, and Roopsha Samanta. “Lipschitz Robustness of Timed I/O Systems,” 9583:250–67. Springer, 2016. <a href=\"https://doi.org/10.1007/978-3-662-49122-5_12\">https://doi.org/10.1007/978-3-662-49122-5_12</a>.","ieee":"T. A. Henzinger, J. Otop, and R. Samanta, “Lipschitz robustness of timed I/O systems,” presented at the VMCAI: Verification, Model Checking and Abstract Interpretation, St. Petersburg, FL, USA, 2016, vol. 9583, pp. 250–267."},"oa":1,"publication_status":"published","date_published":"2016-01-01T00:00:00Z","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1506.01233"}]},{"day":"01","author":[{"first_name":"Krishnendu","last_name":"Chatterjee","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","full_name":"Chatterjee, Krishnendu"},{"full_name":"Chmelik, Martin","id":"3624234E-F248-11E8-B48F-1D18A9856A87","first_name":"Martin","last_name":"Chmelik"},{"last_name":"Gupta","first_name":"Raghav","full_name":"Gupta, Raghav"},{"last_name":"Kanodia","first_name":"Ayush","full_name":"Kanodia, Ayush"}],"publist_id":"5642","arxiv":1,"title":"Optimal cost almost-sure reachability in POMDPs","department":[{"_id":"KrCh"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Elsevier","scopus_import":1,"article_processing_charge":"No","ec_funded":1,"publication":"Artificial Intelligence","quality_controlled":"1","doi":"10.1016/j.artint.2016.01.007","project":[{"grant_number":"P 23499-N23","name":"Modern Graph Algorithmic Techniques in Formal Verification","_id":"2584A770-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"grant_number":"S 11407_N23","call_identifier":"FWF","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering"},{"name":"Quantitative Graph Games: Theory and Applications","_id":"2581B60A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"279307"}],"language":[{"iso":"eng"}],"type":"journal_article","month":"05","oa_version":"Preprint","date_updated":"2023-02-23T12:25:49Z","abstract":[{"text":"We consider partially observable Markov decision processes (POMDPs) with a set of target states and an integer cost associated with every transition. The optimization objective we study asks to minimize the expected total cost of reaching a state in the target set, while ensuring that the target set is reached almost surely (with probability 1). We show that for integer costs approximating the optimal cost is undecidable. For positive costs, our results are as follows: (i) we establish matching lower and upper bounds for the optimal cost, both double exponential in the POMDP state space size; (ii) we show that the problem of approximating the optimal cost is decidable and present approximation algorithms developing on the existing algorithms for POMDPs with finite-horizon objectives. While the worst-case running time of our algorithm is double exponential, we also present efficient stopping criteria for the algorithm and show experimentally that it performs well in many examples of interest.","lang":"eng"}],"page":"26 - 48","date_created":"2018-12-11T11:52:33Z","volume":234,"year":"2016","acknowledgement":"We thank Blai Bonet for helping us with RTDP-Bel. The research was partly supported by Austrian Science Fund (FWF) Grant No P23499-N23, FWF NFN Grant No S11407-N23 (RiSE), ERC Start grant (279307: Graph Games), and Microsoft faculty fellows award.","_id":"1529","oa":1,"publication_status":"published","main_file_link":[{"url":"http://arxiv.org/abs/1411.3880","open_access":"1"}],"date_published":"2016-05-01T00:00:00Z","status":"public","external_id":{"arxiv":["1411.3880"]},"citation":{"ama":"Chatterjee K, Chmelik M, Gupta R, Kanodia A. Optimal cost almost-sure reachability in POMDPs. <i>Artificial Intelligence</i>. 2016;234:26-48. doi:<a href=\"https://doi.org/10.1016/j.artint.2016.01.007\">10.1016/j.artint.2016.01.007</a>","ista":"Chatterjee K, Chmelik M, Gupta R, Kanodia A. 2016. Optimal cost almost-sure reachability in POMDPs. Artificial Intelligence. 234, 26–48.","mla":"Chatterjee, Krishnendu, et al. “Optimal Cost Almost-Sure Reachability in POMDPs.” <i>Artificial Intelligence</i>, vol. 234, Elsevier, 2016, pp. 26–48, doi:<a href=\"https://doi.org/10.1016/j.artint.2016.01.007\">10.1016/j.artint.2016.01.007</a>.","apa":"Chatterjee, K., Chmelik, M., Gupta, R., &#38; Kanodia, A. (2016). Optimal cost almost-sure reachability in POMDPs. <i>Artificial Intelligence</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.artint.2016.01.007\">https://doi.org/10.1016/j.artint.2016.01.007</a>","ieee":"K. Chatterjee, M. Chmelik, R. Gupta, and A. Kanodia, “Optimal cost almost-sure reachability in POMDPs,” <i>Artificial Intelligence</i>, vol. 234. Elsevier, pp. 26–48, 2016.","chicago":"Chatterjee, Krishnendu, Martin Chmelik, Raghav Gupta, and Ayush Kanodia. “Optimal Cost Almost-Sure Reachability in POMDPs.” <i>Artificial Intelligence</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.artint.2016.01.007\">https://doi.org/10.1016/j.artint.2016.01.007</a>.","short":"K. Chatterjee, M. Chmelik, R. Gupta, A. Kanodia, Artificial Intelligence 234 (2016) 26–48."},"intvolume":"       234","related_material":{"record":[{"id":"1820","status":"public","relation":"earlier_version"},{"status":"public","id":"5425","relation":"earlier_version"}]}},{"citation":{"apa":"Nam, P., Napiórkowski, M. M., &#38; Solovej, J. (2016). Diagonalization of bosonic quadratic Hamiltonians by Bogoliubov transformations. <i>Journal of Functional Analysis</i>. Academic Press. <a href=\"https://doi.org/10.1016/j.jfa.2015.12.007\">https://doi.org/10.1016/j.jfa.2015.12.007</a>","mla":"Nam, Phan, et al. “Diagonalization of Bosonic Quadratic Hamiltonians by Bogoliubov Transformations.” <i>Journal of Functional Analysis</i>, vol. 270, no. 11, Academic Press, 2016, pp. 4340–68, doi:<a href=\"https://doi.org/10.1016/j.jfa.2015.12.007\">10.1016/j.jfa.2015.12.007</a>.","ista":"Nam P, Napiórkowski MM, Solovej J. 2016. Diagonalization of bosonic quadratic Hamiltonians by Bogoliubov transformations. Journal of Functional Analysis. 270(11), 4340–4368.","ama":"Nam P, Napiórkowski MM, Solovej J. Diagonalization of bosonic quadratic Hamiltonians by Bogoliubov transformations. <i>Journal of Functional Analysis</i>. 2016;270(11):4340-4368. doi:<a href=\"https://doi.org/10.1016/j.jfa.2015.12.007\">10.1016/j.jfa.2015.12.007</a>","short":"P. Nam, M.M. Napiórkowski, J. Solovej, Journal of Functional Analysis 270 (2016) 4340–4368.","chicago":"Nam, Phan, Marcin M Napiórkowski, and Jan Solovej. “Diagonalization of Bosonic Quadratic Hamiltonians by Bogoliubov Transformations.” <i>Journal of Functional Analysis</i>. Academic Press, 2016. <a href=\"https://doi.org/10.1016/j.jfa.2015.12.007\">https://doi.org/10.1016/j.jfa.2015.12.007</a>.","ieee":"P. Nam, M. M. Napiórkowski, and J. Solovej, “Diagonalization of bosonic quadratic Hamiltonians by Bogoliubov transformations,” <i>Journal of Functional Analysis</i>, vol. 270, no. 11. Academic Press, pp. 4340–4368, 2016."},"intvolume":"       270","status":"public","main_file_link":[{"url":"http://arxiv.org/abs/1508.07321","open_access":"1"}],"date_published":"2016-06-01T00:00:00Z","oa":1,"publication_status":"published","_id":"1545","year":"2016","acknowledgement":"We thank Jan Dereziński for several inspiring discussions and useful remarks. We thank the referee for helpful comments. J.P.S. thanks the Erwin Schrödinger Institute for the hospitality during the thematic programme “Quantum many-body systems, random matrices, and disorder”. We gratefully acknowledge the financial supports by the European Union's Seventh Framework Programme under the ERC Advanced Grant ERC-2012-AdG 321029 (J.P.S.) and the REA grant agreement No. 291734 (P.T.N.), as well as the support of the National Science Center (NCN) grant No. 2012/07/N/ST1/03185 and the Austrian Science Fund (FWF) project No. P 27533-N27 (M.N.).","date_created":"2018-12-11T11:52:38Z","volume":270,"date_updated":"2021-01-12T06:51:30Z","abstract":[{"text":"We provide general conditions for which bosonic quadratic Hamiltonians on Fock spaces can be diagonalized by Bogoliubov transformations. Our results cover the case when quantum systems have infinite degrees of freedom and the associated one-body kinetic and paring operators are unbounded. Our sufficient conditions are optimal in the sense that they become necessary when the relevant one-body operators commute.","lang":"eng"}],"type":"journal_article","oa_version":"Submitted Version","month":"06","page":"4340 - 4368","language":[{"iso":"eng"}],"issue":"11","project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"},{"_id":"25C878CE-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Structure of the Excitation Spectrum for Many-Body Quantum Systems","grant_number":"P27533_N27"}],"quality_controlled":"1","doi":"10.1016/j.jfa.2015.12.007","scopus_import":1,"ec_funded":1,"publication":"Journal of Functional Analysis","department":[{"_id":"RoSe"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Academic Press","publist_id":"5626","title":"Diagonalization of bosonic quadratic Hamiltonians by Bogoliubov transformations","day":"01","author":[{"last_name":"Nam","first_name":"Phan","full_name":"Nam, Phan","id":"404092F4-F248-11E8-B48F-1D18A9856A87"},{"id":"4197AD04-F248-11E8-B48F-1D18A9856A87","full_name":"Napiórkowski, Marcin M","last_name":"Napiórkowski","first_name":"Marcin M"},{"last_name":"Solovej","first_name":"Jan","full_name":"Solovej, Jan"}]},{"citation":{"ama":"Qi Q, Toll Riera M, Heilbron K, Preston G, Maclean RC. The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. 2016;283(1822). doi:<a href=\"https://doi.org/10.1098/rspb.2015.2452\">10.1098/rspb.2015.2452</a>","mla":"Qi, Qin, et al. “The Genomic Basis of Adaptation to the Fitness Cost of Rifampicin Resistance in Pseudomonas Aeruginosa.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 283, no. 1822, 20152452, Royal Society, The, 2016, doi:<a href=\"https://doi.org/10.1098/rspb.2015.2452\">10.1098/rspb.2015.2452</a>.","ista":"Qi Q, Toll Riera M, Heilbron K, Preston G, Maclean RC. 2016. The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa. Proceedings of the Royal Society of London Series B Biological Sciences. 283(1822), 20152452.","apa":"Qi, Q., Toll Riera, M., Heilbron, K., Preston, G., &#38; Maclean, R. C. (2016). The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa. <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, The. <a href=\"https://doi.org/10.1098/rspb.2015.2452\">https://doi.org/10.1098/rspb.2015.2452</a>","ieee":"Q. Qi, M. Toll Riera, K. Heilbron, G. Preston, and R. C. Maclean, “The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa,” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>, vol. 283, no. 1822. Royal Society, The, 2016.","chicago":"Qi, Qin, Macarena Toll Riera, Karl Heilbron, Gail Preston, and R Craig Maclean. “The Genomic Basis of Adaptation to the Fitness Cost of Rifampicin Resistance in Pseudomonas Aeruginosa.” <i>Proceedings of the Royal Society of London Series B Biological Sciences</i>. Royal Society, The, 2016. <a href=\"https://doi.org/10.1098/rspb.2015.2452\">https://doi.org/10.1098/rspb.2015.2452</a>.","short":"Q. Qi, M. Toll Riera, K. Heilbron, G. Preston, R.C. Maclean, Proceedings of the Royal Society of London Series B Biological Sciences 283 (2016)."},"intvolume":"       283","status":"public","date_published":"2016-01-13T00:00:00Z","ddc":["570"],"has_accepted_license":"1","publication_status":"published","oa":1,"_id":"1552","year":"2016","acknowledgement":"We thank the High-Throughput Genomics Group at the Wellcome Trust Centre for Human Genetics funded by Wellcome\r\nTrust grant reference 090532/Z/09/Z and Medical Research Council Hub grant no. G0900747 91070 for generation of the high-throughput sequencing data. We thank Wook Kim and two anonymous reviewers for their constructive feedback on previous versions of our manuscript.","date_created":"2018-12-11T11:52:40Z","file_date_updated":"2020-07-14T12:45:02Z","volume":283,"date_updated":"2021-01-12T06:51:33Z","abstract":[{"text":"Antibiotic resistance carries a fitness cost that must be overcome in order for resistance to persist over the long term. Compensatory mutations that recover the functional defects associated with resistance mutations have been argued to play a key role in overcoming the cost of resistance, but compensatory mutations are expected to be rare relative to generally beneficial mutations that increase fitness, irrespective of antibiotic resistance. Given this asymmetry, population genetics theory predicts that populations should adapt by compensatory mutations when the cost of resistance is large, whereas generally beneficial mutations should drive adaptation when the cost of resistance is small. We tested this prediction by determining the genomic mechanisms underpinning adaptation to antibiotic-free conditions in populations of the pathogenic bacterium Pseudomonas aeruginosa that carry costly antibiotic resistance mutations. Whole-genome sequencing revealed that populations founded by high-cost rifampicin-resistant mutants adapted via compensatory mutations in three genes of the RNA polymerase core enzyme, whereas populations founded by low-cost mutants adapted by generally beneficial mutations, predominantly in the quorum-sensing transcriptional regulator gene lasR. Even though the importance of compensatory evolution in maintaining resistance has been widely recognized, our study shows that the roles of general adaptation in maintaining resistance should not be underestimated and highlights the need to understand how selection at other sites in the genome influences the dynamics of resistance alleles in clinical settings.","lang":"eng"}],"type":"journal_article","month":"01","oa_version":"Published Version","language":[{"iso":"eng"}],"issue":"1822","quality_controlled":"1","doi":"10.1098/rspb.2015.2452","pubrep_id":"488","scopus_import":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publication":"Proceedings of the Royal Society of London Series B Biological Sciences","department":[{"_id":"ToBo"}],"publisher":"Royal Society, The","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publist_id":"5619","title":"The genomic basis of adaptation to the fitness cost of rifampicin resistance in Pseudomonas aeruginosa","article_number":"20152452","day":"13","file":[{"creator":"system","content_type":"application/pdf","relation":"main_file","file_size":626804,"file_name":"IST-2016-488-v1+1_20152452.full.pdf","access_level":"open_access","date_created":"2018-12-12T10:11:43Z","checksum":"78ffe70c1c88af3856d31ca6b7195a27","date_updated":"2020-07-14T12:45:02Z","file_id":"4899"}],"author":[{"full_name":"Qi, Qin","id":"3B22D412-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6148-2416","first_name":"Qin","last_name":"Qi"},{"full_name":"Toll Riera, Macarena","first_name":"Macarena","last_name":"Toll Riera"},{"full_name":"Heilbron, Karl","last_name":"Heilbron","first_name":"Karl"},{"first_name":"Gail","last_name":"Preston","full_name":"Preston, Gail"},{"last_name":"Maclean","first_name":"R Craig","full_name":"Maclean, R Craig"}]},{"page":"186 - 190","month":"01","oa_version":"Submitted Version","type":"journal_article","date_updated":"2021-01-12T06:51:52Z","abstract":[{"lang":"eng","text":"The addition of polysialic acid to N- and/or O-linked glycans, referred to as polysialylation, is a rare posttranslational modification that is mainly known to control the developmental plasticity of the nervous system. Here we show that CCR7, the central chemokine receptor controlling immune cell trafficking to secondary lymphatic organs, carries polysialic acid. This modification is essential for the recognition of the CCR7 ligand CCL21. As a consequence, dendritic cell trafficking is abrogated in polysialyltransferase-deficient mice, manifesting as disturbed lymph node homeostasis and unresponsiveness to inflammatory stimuli. Structure-function analysis of chemokine-receptor interactions reveals that CCL21 adopts an autoinhibited conformation, which is released upon interaction with polysialic acid. Thus, we describe a glycosylation-mediated immune cell trafficking disorder and its mechanistic basis.\r\n"}],"volume":351,"date_created":"2018-12-11T11:52:57Z","acknowledgement":"We thank S. Schüchner and E. Ogris for kindly providing the antibody to GFP, M. Helmbrecht and A. Huber for providing Nrp2−/− mice, the IST Scientific Support Facilities for excellent services, and J. Renkawitz and K. Vaahtomeri for critically reading the manuscript. ","year":"2016","_id":"1599","publication_status":"published","oa":1,"date_published":"2016-01-08T00:00:00Z","acknowledged_ssus":[{"_id":"SSU"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583642/"}],"external_id":{"pmid":["26657283"]},"status":"public","intvolume":"       351","citation":{"short":"E. Kiermaier, C. Moussion, C. Veldkamp, R. Gerardy  Schahn, I. de Vries, L. Williams, G. Chaffee, A. Phillips, F. Freiberger, R. Imre, D. Taleski, R. Payne, A. Braun, R. Förster, K. Mechtler, M. Mühlenhoff, B. Volkman, M.K. Sixt, Science 351 (2016) 186–190.","ieee":"E. Kiermaier <i>et al.</i>, “Polysialylation controls dendritic cell trafficking by regulating chemokine recognition,” <i>Science</i>, vol. 351, no. 6269. American Association for the Advancement of Science, pp. 186–190, 2016.","chicago":"Kiermaier, Eva, Christine Moussion, Christopher Veldkamp, Rita Gerardy  Schahn, Ingrid de Vries, Larry Williams, Gary Chaffee, et al. “Polysialylation Controls Dendritic Cell Trafficking by Regulating Chemokine Recognition.” <i>Science</i>. American Association for the Advancement of Science, 2016. <a href=\"https://doi.org/10.1126/science.aad0512\">https://doi.org/10.1126/science.aad0512</a>.","mla":"Kiermaier, Eva, et al. “Polysialylation Controls Dendritic Cell Trafficking by Regulating Chemokine Recognition.” <i>Science</i>, vol. 351, no. 6269, American Association for the Advancement of Science, 2016, pp. 186–90, doi:<a href=\"https://doi.org/10.1126/science.aad0512\">10.1126/science.aad0512</a>.","ista":"Kiermaier E, Moussion C, Veldkamp C, Gerardy  Schahn R, de Vries I, Williams L, Chaffee G, Phillips A, Freiberger F, Imre R, Taleski D, Payne R, Braun A, Förster R, Mechtler K, Mühlenhoff M, Volkman B, Sixt MK. 2016. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science. 351(6269), 186–190.","apa":"Kiermaier, E., Moussion, C., Veldkamp, C., Gerardy  Schahn, R., de Vries, I., Williams, L., … Sixt, M. K. (2016). Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aad0512\">https://doi.org/10.1126/science.aad0512</a>","ama":"Kiermaier E, Moussion C, Veldkamp C, et al. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. <i>Science</i>. 2016;351(6269):186-190. doi:<a href=\"https://doi.org/10.1126/science.aad0512\">10.1126/science.aad0512</a>"},"author":[{"orcid":"0000-0001-6165-5738","id":"3EB04B78-F248-11E8-B48F-1D18A9856A87","full_name":"Kiermaier, Eva","first_name":"Eva","last_name":"Kiermaier"},{"full_name":"Moussion, Christine","id":"3356F664-F248-11E8-B48F-1D18A9856A87","last_name":"Moussion","first_name":"Christine"},{"first_name":"Christopher","last_name":"Veldkamp","full_name":"Veldkamp, Christopher"},{"full_name":"Gerardy  Schahn, Rita","first_name":"Rita","last_name":"Gerardy  Schahn"},{"first_name":"Ingrid","last_name":"De Vries","full_name":"De Vries, Ingrid","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Williams, Larry","first_name":"Larry","last_name":"Williams"},{"first_name":"Gary","last_name":"Chaffee","full_name":"Chaffee, Gary"},{"first_name":"Andrew","last_name":"Phillips","full_name":"Phillips, Andrew"},{"full_name":"Freiberger, Friedrich","first_name":"Friedrich","last_name":"Freiberger"},{"first_name":"Richard","last_name":"Imre","full_name":"Imre, Richard"},{"last_name":"Taleski","first_name":"Deni","full_name":"Taleski, Deni"},{"last_name":"Payne","first_name":"Richard","full_name":"Payne, Richard"},{"last_name":"Braun","first_name":"Asolina","full_name":"Braun, Asolina"},{"last_name":"Förster","first_name":"Reinhold","full_name":"Förster, Reinhold"},{"first_name":"Karl","last_name":"Mechtler","full_name":"Mechtler, Karl"},{"full_name":"Mühlenhoff, Martina","last_name":"Mühlenhoff","first_name":"Martina"},{"last_name":"Volkman","first_name":"Brian","full_name":"Volkman, Brian"},{"full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt"}],"day":"08","title":"Polysialylation controls dendritic cell trafficking by regulating chemokine recognition","publist_id":"5570","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"American Association for the Advancement of Science","department":[{"_id":"MiSi"}],"pmid":1,"publication":"Science","article_type":"original","scopus_import":1,"ec_funded":1,"article_processing_charge":"No","doi":"10.1126/science.aad0512","quality_controlled":"1","project":[{"grant_number":"281556","_id":"25A603A2-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)"},{"grant_number":"289720","name":"Stromal Cell-immune Cell Interactions in Health and Disease","call_identifier":"FP7","_id":"25A76F58-B435-11E9-9278-68D0E5697425"},{"name":"Cytoskeletal force generation and transduction of leukocytes (FWF)","call_identifier":"FWF","_id":"25A8E5EA-B435-11E9-9278-68D0E5697425","grant_number":"Y 564-B12"}],"issue":"6269","language":[{"iso":"eng"}]},{"department":[{"_id":"LaEr"}],"publisher":"Birkhäuser","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","ec_funded":1,"scopus_import":1,"publication":"Annales Henri Poincare","day":"01","author":[{"first_name":"Christian","last_name":"Sadel","full_name":"Sadel, Christian","orcid":"0000-0001-8255-3968","id":"4760E9F8-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"5558","title":"Anderson transition at 2 dimensional growth rate on antitrees and spectral theory for operators with one propagating channel","project":[{"grant_number":"291734","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"language":[{"iso":"eng"}],"issue":"7","quality_controlled":"1","doi":"10.1007/s00023-015-0456-3","year":"2016","_id":"1608","abstract":[{"text":"We show that the Anderson model has a transition from localization to delocalization at exactly 2 dimensional growth rate on antitrees with normalized edge weights which are certain discrete graphs. The kinetic part has a one-dimensional structure allowing a description through transfer matrices which involve some Schur complement. For such operators we introduce the notion of having one propagating channel and extend theorems from the theory of one-dimensional Jacobi operators that relate the behavior of transfer matrices with the spectrum. These theorems are then applied to the considered model. In essence, in a certain energy region the kinetic part averages the random potentials along shells and the transfer matrices behave similar as for a one-dimensional operator with random potential of decaying variance. At d dimensional growth for d&gt;2 this effective decay is strong enough to obtain absolutely continuous spectrum, whereas for some uniform d dimensional growth with d&lt;2 one has pure point spectrum in this energy region. At exactly uniform 2 dimensional growth also some singular continuous spectrum appears, at least at small disorder. As a corollary we also obtain a change from singular spectrum (d≤2) to absolutely continuous spectrum (d≥3) for random operators of the type rΔdr+λ on ℤd, where r is an orthogonal radial projection, Δd the discrete adjacency operator (Laplacian) on ℤd and λ a random potential. ","lang":"eng"}],"date_updated":"2021-01-12T06:51:58Z","type":"journal_article","month":"07","oa_version":"Preprint","page":"1631 - 1675","date_created":"2018-12-11T11:53:00Z","volume":17,"status":"public","citation":{"chicago":"Sadel, Christian. “Anderson Transition at 2 Dimensional Growth Rate on Antitrees and Spectral Theory for Operators with One Propagating Channel.” <i>Annales Henri Poincare</i>. Birkhäuser, 2016. <a href=\"https://doi.org/10.1007/s00023-015-0456-3\">https://doi.org/10.1007/s00023-015-0456-3</a>.","ieee":"C. Sadel, “Anderson transition at 2 dimensional growth rate on antitrees and spectral theory for operators with one propagating channel,” <i>Annales Henri Poincare</i>, vol. 17, no. 7. Birkhäuser, pp. 1631–1675, 2016.","short":"C. Sadel, Annales Henri Poincare 17 (2016) 1631–1675.","ama":"Sadel C. Anderson transition at 2 dimensional growth rate on antitrees and spectral theory for operators with one propagating channel. <i>Annales Henri Poincare</i>. 2016;17(7):1631-1675. doi:<a href=\"https://doi.org/10.1007/s00023-015-0456-3\">10.1007/s00023-015-0456-3</a>","apa":"Sadel, C. (2016). Anderson transition at 2 dimensional growth rate on antitrees and spectral theory for operators with one propagating channel. <i>Annales Henri Poincare</i>. Birkhäuser. <a href=\"https://doi.org/10.1007/s00023-015-0456-3\">https://doi.org/10.1007/s00023-015-0456-3</a>","ista":"Sadel C. 2016. Anderson transition at 2 dimensional growth rate on antitrees and spectral theory for operators with one propagating channel. Annales Henri Poincare. 17(7), 1631–1675.","mla":"Sadel, Christian. “Anderson Transition at 2 Dimensional Growth Rate on Antitrees and Spectral Theory for Operators with One Propagating Channel.” <i>Annales Henri Poincare</i>, vol. 17, no. 7, Birkhäuser, 2016, pp. 1631–75, doi:<a href=\"https://doi.org/10.1007/s00023-015-0456-3\">10.1007/s00023-015-0456-3</a>."},"intvolume":"        17","publication_status":"published","oa":1,"main_file_link":[{"url":"http://arxiv.org/abs/1501.04287","open_access":"1"}],"date_published":"2016-07-01T00:00:00Z"},{"intvolume":"        75","citation":{"mla":"Kazda, Alexandr. “CSP for Binary Conservative Relational Structures.” <i>Algebra Universalis</i>, vol. 75, no. 1, Springer, 2016, pp. 75–84, doi:<a href=\"https://doi.org/10.1007/s00012-015-0358-8\">10.1007/s00012-015-0358-8</a>.","ista":"Kazda A. 2016. CSP for binary conservative relational structures. Algebra Universalis. 75(1), 75–84.","apa":"Kazda, A. (2016). CSP for binary conservative relational structures. <i>Algebra Universalis</i>. Springer. <a href=\"https://doi.org/10.1007/s00012-015-0358-8\">https://doi.org/10.1007/s00012-015-0358-8</a>","ama":"Kazda A. CSP for binary conservative relational structures. <i>Algebra Universalis</i>. 2016;75(1):75-84. doi:<a href=\"https://doi.org/10.1007/s00012-015-0358-8\">10.1007/s00012-015-0358-8</a>","short":"A. Kazda, Algebra Universalis 75 (2016) 75–84.","ieee":"A. Kazda, “CSP for binary conservative relational structures,” <i>Algebra Universalis</i>, vol. 75, no. 1. Springer, pp. 75–84, 2016.","chicago":"Kazda, Alexandr. “CSP for Binary Conservative Relational Structures.” <i>Algebra Universalis</i>. Springer, 2016. <a href=\"https://doi.org/10.1007/s00012-015-0358-8\">https://doi.org/10.1007/s00012-015-0358-8</a>."},"language":[{"iso":"eng"}],"issue":"1","status":"public","date_published":"2016-02-01T00:00:00Z","doi":"10.1007/s00012-015-0358-8","main_file_link":[{"open_access":"1","url":"http://arxiv.org/abs/1112.1099"}],"quality_controlled":"1","oa":1,"publication_status":"published","publication":"Algebra Universalis","_id":"1612","scopus_import":1,"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Springer","department":[{"_id":"VlKo"}],"year":"2016","volume":75,"title":"CSP for binary conservative relational structures","publist_id":"5554","date_created":"2018-12-11T11:53:01Z","page":"75 - 84","author":[{"last_name":"Kazda","first_name":"Alexandr","id":"3B32BAA8-F248-11E8-B48F-1D18A9856A87","full_name":"Kazda, Alexandr"}],"date_updated":"2021-01-12T06:52:00Z","day":"01","abstract":[{"lang":"eng","text":"We prove that whenever A is a 3-conservative relational structure with only binary and unary relations,then the algebra of polymorphisms of A either has no Taylor operation (i.e.,CSP(A)is NP-complete),or it generates an SD(∧) variety (i.e.,CSP(A)has bounded width)."}],"oa_version":"Preprint","month":"02","type":"journal_article"},{"language":[{"iso":"eng"}],"quality_controlled":"1","doi":"doi:10.1016/j.mcn.2015.11.010","pubrep_id":"979","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"publication":"Molecular and Cellular Neuroscience","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Academic Press","publist_id":"5553","title":"Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells","day":"01","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","file":[{"file_name":"IST-2018-979-v1+1_Mungenast_2015_acceptedManuscript.pdf","file_size":632915,"relation":"main_file","content_type":"application/pdf","creator":"system","file_id":"4970","date_updated":"2020-07-14T12:45:07Z","checksum":"620254114e04d5d6e7f37d15e4b8ace4","date_created":"2018-12-12T10:12:50Z","access_level":"open_access"}],"author":[{"last_name":"Mungenast","first_name":"Alison","full_name":"Mungenast, Alison"},{"last_name":"Siegert","first_name":"Sandra","full_name":"Siegert, Sandra","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8635-0877"},{"first_name":"Li","last_name":"Tsai","full_name":"Tsai, Li"}],"citation":{"ieee":"A. Mungenast, S. Siegert, and L. Tsai, “Modeling Alzheimer’s disease with human induced pluripotent stem (iPS) cells,” <i>Molecular and Cellular Neuroscience</i>, vol. 73. Academic Press, pp. 13–31, 2016.","chicago":"Mungenast, Alison, Sandra Siegert, and Li Tsai. “Modeling Alzheimer’s Disease with Human Induced Pluripotent Stem (IPS) Cells.” <i>Molecular and Cellular Neuroscience</i>. Academic Press, 2016. <a href=\"https://doi.org/doi:10.1016/j.mcn.2015.11.010\">https://doi.org/doi:10.1016/j.mcn.2015.11.010</a>.","short":"A. Mungenast, S. Siegert, L. Tsai, Molecular and Cellular Neuroscience 73 (2016) 13–31.","ama":"Mungenast A, Siegert S, Tsai L. Modeling Alzheimer’s disease with human induced pluripotent stem (iPS) cells. <i>Molecular and Cellular Neuroscience</i>. 2016;73:13-31. doi:<a href=\"https://doi.org/doi:10.1016/j.mcn.2015.11.010\">doi:10.1016/j.mcn.2015.11.010</a>","ista":"Mungenast A, Siegert S, Tsai L. 2016. Modeling Alzheimer’s disease with human induced pluripotent stem (iPS) cells. Molecular and Cellular Neuroscience. 73, 13–31.","mla":"Mungenast, Alison, et al. “Modeling Alzheimer’s Disease with Human Induced Pluripotent Stem (IPS) Cells.” <i>Molecular and Cellular Neuroscience</i>, vol. 73, Academic Press, 2016, pp. 13–31, doi:<a href=\"https://doi.org/doi:10.1016/j.mcn.2015.11.010\">doi:10.1016/j.mcn.2015.11.010</a>.","apa":"Mungenast, A., Siegert, S., &#38; Tsai, L. (2016). Modeling Alzheimer’s disease with human induced pluripotent stem (iPS) cells. <i>Molecular and Cellular Neuroscience</i>. Academic Press. <a href=\"https://doi.org/doi:10.1016/j.mcn.2015.11.010\">https://doi.org/doi:10.1016/j.mcn.2015.11.010</a>"},"extern":"1","intvolume":"        73","status":"public","ddc":["616"],"date_published":"2016-06-01T00:00:00Z","has_accepted_license":"1","oa":1,"publication_status":"published","_id":"1613","year":"2016","acknowledgement":"This work was supported by NIH grant R01-AG047661 to LHT. The art in Fig. 1 was created by Julian Wong.","date_created":"2018-12-11T11:53:02Z","file_date_updated":"2020-07-14T12:45:07Z","volume":73,"type":"journal_article","month":"06","oa_version":"Submitted Version","abstract":[{"lang":"eng","text":"In the last decade, induced pluripotent stem (iPS) cells have revolutionized the utility of human in vitro models of neurological disease. The iPS-derived and differentiated cells allow researchers to study the impact of a distinct cell type in health and disease as well as performing therapeutic drug screens on a human genetic background. In particular, clinical trials for Alzheimer's disease (AD) have been often failing. Two of the potential reasons are first, the species gap involved in proceeding from initial discoveries in rodent models to human studies, and second, an unsatisfying patient stratification, meaning subgrouping patients based on the disease severity due to the lack of phenotypic and genetic markers. iPS cells overcome this obstacles and will improve our understanding of disease subtypes in AD. They allow researchers conducting in depth characterization of neural cells from both familial and sporadic AD patients as well as preclinical screens on human cells.\r\n\r\nIn this review, we briefly outline the status quo of iPS cell research in neurological diseases along with the general advantages and pitfalls of these models. We summarize how genome-editing techniques such as CRISPR/Cas will allow researchers to reduce the problem of genomic variability inherent to human studies, followed by recent iPS cell studies relevant to AD. We then focus on current techniques for the differentiation of iPS cells into neural cell types that are relevant to AD research. Finally, we discuss how the generation of three-dimensional cell culture systems will be important for understanding AD phenotypes in a complex cellular milieu, and how both two- and three-dimensional iPS cell models can provide platforms for drug discovery and translational studies into the treatment of AD."}],"date_updated":"2021-01-12T06:52:00Z","page":"13 - 31"},{"year":"2016","publisher":"Taylor & Francis","publication":"Communications in Partial Differential Equations","_id":"1318","abstract":[{"lang":"eng","text":"We develop a large-scale regularity theory of higher order for divergence-form elliptic equations with heterogeneous coefficient fields a in the context of stochastic homogenization. The large-scale regularity of a-harmonic functions is encoded by Liouville principles: The space of a-harmonic functions that grow at most like a polynomial of degree k has the same dimension as in the constant-coefficient case. This result can be seen as the qualitative side of a large-scale Ck,α-regularity theory, which in the present work is developed in the form of a corresponding Ck,α-“excess decay” estimate: For a given a-harmonic function u on a ball BR, its energy distance on some ball Br to the above space of a-harmonic functions that grow at most like a polynomial of degree k has the natural decay in the radius r above some minimal radius r0. Though motivated by stochastic homogenization, the contribution of this paper is of purely deterministic nature: We work under the assumption that for the given realization a of the coefficient field, the couple (φ, σ) of scalar and vector potentials of the harmonic coordinates, where φ is the usual corrector, grows sublinearly in a mildly quantified way. We then construct “kth-order correctors” and thereby the space of a-harmonic functions that grow at most like a polynomial of degree k, establish the above excess decay, and then the corresponding Liouville principle."}],"date_updated":"2021-01-12T06:49:50Z","day":"02","type":"journal_article","month":"07","page":"1108 - 1148","author":[{"last_name":"Fischer","first_name":"Julian L","full_name":"Julian Fischer","orcid":"0000-0002-0479-558X","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Otto, Felix","first_name":"Felix","last_name":"Otto"}],"publist_id":"5953","date_created":"2018-12-11T11:51:20Z","title":"A higher-order large scale regularity theory for random elliptic operators","volume":41,"status":"public","citation":{"short":"J.L. Fischer, F. Otto, Communications in Partial Differential Equations 41 (2016) 1108–1148.","ieee":"J. L. Fischer and F. Otto, “A higher-order large scale regularity theory for random elliptic operators,” <i>Communications in Partial Differential Equations</i>, vol. 41, no. 7. Taylor &#38; Francis, pp. 1108–1148, 2016.","chicago":"Fischer, Julian L, and Felix Otto. “A Higher-Order Large Scale Regularity Theory for Random Elliptic Operators.” <i>Communications in Partial Differential Equations</i>. Taylor &#38; Francis, 2016. <a href=\"https://doi.org/10.1080/03605302.2016.1179318\">https://doi.org/10.1080/03605302.2016.1179318</a>.","ista":"Fischer JL, Otto F. 2016. A higher-order large scale regularity theory for random elliptic operators. Communications in Partial Differential Equations. 41(7), 1108–1148.","mla":"Fischer, Julian L., and Felix Otto. “A Higher-Order Large Scale Regularity Theory for Random Elliptic Operators.” <i>Communications in Partial Differential Equations</i>, vol. 41, no. 7, Taylor &#38; Francis, 2016, pp. 1108–48, doi:<a href=\"https://doi.org/10.1080/03605302.2016.1179318\">10.1080/03605302.2016.1179318</a>.","apa":"Fischer, J. L., &#38; Otto, F. (2016). A higher-order large scale regularity theory for random elliptic operators. <i>Communications in Partial Differential Equations</i>. Taylor &#38; Francis. <a href=\"https://doi.org/10.1080/03605302.2016.1179318\">https://doi.org/10.1080/03605302.2016.1179318</a>","ama":"Fischer JL, Otto F. A higher-order large scale regularity theory for random elliptic operators. <i>Communications in Partial Differential Equations</i>. 2016;41(7):1108-1148. doi:<a href=\"https://doi.org/10.1080/03605302.2016.1179318\">10.1080/03605302.2016.1179318</a>"},"issue":"7","intvolume":"        41","extern":1,"oa":1,"publication_status":"published","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1503.07578"}],"quality_controlled":0,"date_published":"2016-07-02T00:00:00Z","doi":"10.1080/03605302.2016.1179318"},{"volume":18,"date_created":"2018-12-11T11:51:21Z","file_date_updated":"2020-07-14T12:44:43Z","page":"1253 - 1259","date_updated":"2024-03-25T23:30:09Z","abstract":[{"text":"Most migrating cells extrude their front by the force of actin polymerization. Polymerization requires an initial nucleation step, which is mediated by factors establishing either parallel filaments in the case of filopodia or branched filaments that form the branched lamellipodial network. Branches are considered essential for regular cell motility and are initiated by the Arp2/3 complex, which in turn is activated by nucleation-promoting factors of the WASP and WAVE families. Here we employed rapid amoeboid crawling leukocytes and found that deletion of the WAVE complex eliminated actin branching and thus lamellipodia formation. The cells were left with parallel filaments at the leading edge, which translated, depending on the differentiation status of the cell, into a unipolar pointed cell shape or cells with multiple filopodia. Remarkably, unipolar cells migrated with increased speed and enormous directional persistence, while they were unable to turn towards chemotactic gradients. Cells with multiple filopodia retained chemotactic activity but their migration was progressively impaired with increasing geometrical complexity of the extracellular environment. These findings establish that diversified leading edge protrusions serve as explorative structures while they slow down actual locomotion.","lang":"eng"}],"month":"10","type":"journal_article","oa_version":"Submitted Version","_id":"1321","acknowledgement":"This work was supported by the German Research Foundation (DFG) Priority Program SP 1464 to T.E.B.S. and M.S., and European Research Council (ERC GA 281556) and Human Frontiers Program grants to M.S.\r\nService Units of IST Austria for excellent technical support.","year":"2016","date_published":"2016-10-24T00:00:00Z","ddc":["570"],"acknowledged_ssus":[{"_id":"SSU"}],"publication_status":"published","oa":1,"has_accepted_license":"1","related_material":{"record":[{"id":"323","status":"public","relation":"dissertation_contains"}]},"intvolume":"        18","citation":{"chicago":"Leithner, Alexander F, Alexander Eichner, Jan Müller, Anne Reversat, Markus Brown, Jan Schwarz, Jack Merrin, et al. “Diversified Actin Protrusions Promote Environmental Exploration but Are Dispensable for Locomotion of Leukocytes.” <i>Nature Cell Biology</i>. Nature Publishing Group, 2016. <a href=\"https://doi.org/10.1038/ncb3426\">https://doi.org/10.1038/ncb3426</a>.","ieee":"A. F. Leithner <i>et al.</i>, “Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes,” <i>Nature Cell Biology</i>, vol. 18. Nature Publishing Group, pp. 1253–1259, 2016.","short":"A.F. Leithner, A. Eichner, J. Müller, A. Reversat, M. Brown, J. Schwarz, J. Merrin, D. De Gorter, F.K. Schur, J. Bayerl, I. de Vries, S. Wieser, R. Hauschild, F. Lai, M. Moser, D. Kerjaschki, K. Rottner, V. Small, T. Stradal, M.K. Sixt, Nature Cell Biology 18 (2016) 1253–1259.","ama":"Leithner AF, Eichner A, Müller J, et al. Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. <i>Nature Cell Biology</i>. 2016;18:1253-1259. doi:<a href=\"https://doi.org/10.1038/ncb3426\">10.1038/ncb3426</a>","apa":"Leithner, A. F., Eichner, A., Müller, J., Reversat, A., Brown, M., Schwarz, J., … Sixt, M. K. (2016). Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. <i>Nature Cell Biology</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncb3426\">https://doi.org/10.1038/ncb3426</a>","ista":"Leithner AF, Eichner A, Müller J, Reversat A, Brown M, Schwarz J, Merrin J, De Gorter D, Schur FK, Bayerl J, de Vries I, Wieser S, Hauschild R, Lai F, Moser M, Kerjaschki D, Rottner K, Small V, Stradal T, Sixt MK. 2016. Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. Nature Cell Biology. 18, 1253–1259.","mla":"Leithner, Alexander F., et al. “Diversified Actin Protrusions Promote Environmental Exploration but Are Dispensable for Locomotion of Leukocytes.” <i>Nature Cell Biology</i>, vol. 18, Nature Publishing Group, 2016, pp. 1253–59, doi:<a href=\"https://doi.org/10.1038/ncb3426\">10.1038/ncb3426</a>."},"status":"public","title":"Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes","publist_id":"5949","author":[{"last_name":"Leithner","first_name":"Alexander F","full_name":"Leithner, Alexander F","orcid":"0000-0002-1073-744X","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Eichner, Alexander","id":"4DFA52AE-F248-11E8-B48F-1D18A9856A87","first_name":"Alexander","last_name":"Eichner"},{"first_name":"Jan","last_name":"Müller","id":"AD07FDB4-0F61-11EA-8158-C4CC64CEAA8D","full_name":"Müller, Jan"},{"first_name":"Anne","last_name":"Reversat","id":"35B76592-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0666-8928","full_name":"Reversat, Anne"},{"last_name":"Brown","first_name":"Markus","full_name":"Brown, Markus","id":"3DAB9AFC-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Schwarz","first_name":"Jan","id":"346C1EC6-F248-11E8-B48F-1D18A9856A87","full_name":"Schwarz, Jan"},{"full_name":"Merrin, Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5145-4609","first_name":"Jack","last_name":"Merrin"},{"full_name":"De Gorter, David","first_name":"David","last_name":"De Gorter"},{"orcid":"0000-0003-4790-8078","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","full_name":"Schur, Florian","last_name":"Schur","first_name":"Florian"},{"first_name":"Jonathan","last_name":"Bayerl","full_name":"Bayerl, Jonathan"},{"first_name":"Ingrid","last_name":"De Vries","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87","full_name":"De Vries, Ingrid"},{"full_name":"Wieser, Stefan","orcid":"0000-0002-2670-2217","id":"355AA5A0-F248-11E8-B48F-1D18A9856A87","last_name":"Wieser","first_name":"Stefan"},{"full_name":"Hauschild, Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9843-3522","first_name":"Robert","last_name":"Hauschild"},{"last_name":"Lai","first_name":"Frank","full_name":"Lai, Frank"},{"last_name":"Moser","first_name":"Markus","full_name":"Moser, Markus"},{"last_name":"Kerjaschki","first_name":"Dontscho","full_name":"Kerjaschki, Dontscho"},{"last_name":"Rottner","first_name":"Klemens","full_name":"Rottner, Klemens"},{"first_name":"Victor","last_name":"Small","full_name":"Small, Victor"},{"full_name":"Stradal, Theresia","first_name":"Theresia","last_name":"Stradal"},{"full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6620-9179","first_name":"Michael K","last_name":"Sixt"}],"file":[{"date_created":"2020-05-14T16:33:46Z","access_level":"open_access","date_updated":"2020-07-14T12:44:43Z","file_id":"7844","checksum":"e1411cb7c99a2d9089c178a6abef25e7","content_type":"application/pdf","relation":"main_file","file_size":4433280,"creator":"dernst","file_name":"2018_NatureCell_Leithner.pdf"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","day":"24","publication":"Nature Cell Biology","article_processing_charge":"No","ec_funded":1,"scopus_import":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","short":"CC BY-NC-SA (4.0)"},"article_type":"original","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Nature Publishing Group","department":[{"_id":"MiSi"},{"_id":"NanoFab"},{"_id":"Bio"}],"doi":"10.1038/ncb3426","quality_controlled":"1","language":[{"iso":"eng"}],"project":[{"name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)","_id":"25A603A2-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"281556"}]},{"_id":"1322","acknowledgement":"CH was funded by the Schrödinger program of the Austrian Science Fund (FWF) J3475. ","year":"2016","volume":11,"date_created":"2018-12-11T11:51:22Z","file_date_updated":"2020-07-14T12:44:44Z","date_updated":"2023-02-23T14:11:27Z","abstract":[{"lang":"eng","text":"Direct reciprocity is a major mechanism for the evolution of cooperation. Several classical studies have suggested that humans should quickly learn to adopt reciprocal strategies to establish mutual cooperation in repeated interactions. On the other hand, the recently discovered theory of ZD strategies has found that subjects who use extortionate strategies are able to exploit and subdue cooperators. Although such extortioners have been predicted to succeed in any population of adaptive opponents, theoretical follow-up studies questioned whether extortion can evolve in reality. However, most of these studies presumed that individuals have similar strategic possibilities and comparable outside options, whereas asymmetries are ubiquitous in real world applications. Here we show with a model and an economic experiment that extortionate strategies readily emerge once subjects differ in their strategic power. Our experiment combines a repeated social dilemma with asymmetric partner choice. In our main treatment there is one randomly chosen group member who is unilaterally allowed to exchange one of the other group members after every ten rounds of the social dilemma. We find that this asymmetric replacement opportunity generally promotes cooperation, but often the resulting payoff distribution reflects the underlying power structure. Almost half of the subjects in a better strategic position turn into extortioners, who quickly proceed to exploit their peers. By adapting their cooperation probabilities consistent with ZD theory, extortioners force their co-players to cooperate without being similarly cooperative themselves. Comparison to non-extortionate players under the same conditions indicates a substantial net gain to extortion. Our results thus highlight how power asymmetries can endanger mutually beneficial interactions, and transform them into exploitative relationships. In particular, our results indicate that the extortionate strategies predicted from ZD theory could play a more prominent role in our daily interactions than previously thought."}],"oa_version":"Published Version","type":"journal_article","month":"10","intvolume":"        11","related_material":{"record":[{"id":"9867","status":"public","relation":"research_data"},{"relation":"research_data","status":"public","id":"9868"}]},"citation":{"chicago":"Hilbe, Christian, Kristin Hagel, and Manfred Milinski. “Asymmetric Power Boosts Extortion in an Economic Experiment.” <i>PLoS One</i>. Public Library of Science, 2016. <a href=\"https://doi.org/10.1371/journal.pone.0163867\">https://doi.org/10.1371/journal.pone.0163867</a>.","ieee":"C. Hilbe, K. Hagel, and M. Milinski, “Asymmetric power boosts extortion in an economic experiment,” <i>PLoS One</i>, vol. 11, no. 10. Public Library of Science, 2016.","short":"C. Hilbe, K. Hagel, M. Milinski, PLoS One 11 (2016).","ama":"Hilbe C, Hagel K, Milinski M. Asymmetric power boosts extortion in an economic experiment. <i>PLoS One</i>. 2016;11(10). doi:<a href=\"https://doi.org/10.1371/journal.pone.0163867\">10.1371/journal.pone.0163867</a>","apa":"Hilbe, C., Hagel, K., &#38; Milinski, M. (2016). Asymmetric power boosts extortion in an economic experiment. <i>PLoS One</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0163867\">https://doi.org/10.1371/journal.pone.0163867</a>","mla":"Hilbe, Christian, et al. “Asymmetric Power Boosts Extortion in an Economic Experiment.” <i>PLoS One</i>, vol. 11, no. 10, e0163867, Public Library of Science, 2016, doi:<a href=\"https://doi.org/10.1371/journal.pone.0163867\">10.1371/journal.pone.0163867</a>.","ista":"Hilbe C, Hagel K, Milinski M. 2016. Asymmetric power boosts extortion in an economic experiment. PLoS One. 11(10), e0163867."},"status":"public","ddc":["004","006"],"date_published":"2016-10-04T00:00:00Z","oa":1,"publication_status":"published","has_accepted_license":"1","publication":"PLoS One","scopus_import":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publisher":"Public Library of Science","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"KrCh"}],"title":"Asymmetric power boosts extortion in an economic experiment","article_number":"e0163867","publist_id":"5948","author":[{"first_name":"Christian","last_name":"Hilbe","orcid":"0000-0001-5116-955X","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87","full_name":"Hilbe, Christian"},{"full_name":"Hagel, Kristin","first_name":"Kristin","last_name":"Hagel"},{"full_name":"Milinski, Manfred","first_name":"Manfred","last_name":"Milinski"}],"file":[{"file_name":"IST-2016-716-v1+1_journal.pone.0163867.PDF","creator":"system","relation":"main_file","content_type":"application/pdf","file_size":2077905,"checksum":"6b33e394003dfe8b4ca6be1858aaa8e3","date_updated":"2020-07-14T12:44:44Z","file_id":"4668","access_level":"open_access","date_created":"2018-12-12T10:08:08Z"}],"day":"04","language":[{"iso":"eng"}],"issue":"10","doi":"10.1371/journal.pone.0163867","quality_controlled":"1","pubrep_id":"716"},{"year":"2016","_id":"1323","type":"journal_article","month":"10","oa_version":"Published Version","date_updated":"2023-02-21T10:34:24Z","abstract":[{"lang":"eng","text":"Mossy fiber synapses on CA3 pyramidal cells are 'conditional detonators' that reliably discharge postsynaptic targets. The 'conditional' nature implies that burst activity in dentate gyrus granule cells is required for detonation. Whether single unitary excitatory postsynaptic potentials (EPSPs) trigger spikes in CA3 neurons remains unknown. Mossy fiber synapses exhibit both pronounced short-term facilitation and uniquely large post-tetanic potentiation (PTP). We tested whether PTP could convert mossy fiber synapses from subdetonator into detonator mode, using a recently developed method to selectively and noninvasively stimulate individual presynaptic terminals in rat brain slices. Unitary EPSPs failed to initiate a spike in CA3 neurons under control conditions, but reliably discharged them after induction of presynaptic short-term plasticity. Remarkably, PTP switched mossy fiber synapses into full detonators for tens of seconds. Plasticity-dependent detonation may be critical for efficient coding, storage, and recall of information in the granule cell–CA3 cell network."}],"volume":5,"date_created":"2018-12-11T11:51:22Z","file_date_updated":"2020-07-14T12:44:44Z","status":"public","intvolume":"         5","citation":{"short":"N. Vyleta, C. Borges Merjane, P.M. Jonas, ELife 5 (2016).","chicago":"Vyleta, Nicholas, Carolina Borges Merjane, and Peter M Jonas. “Plasticity-Dependent, Full Detonation at Hippocampal Mossy Fiber–CA3 Pyramidal Neuron Synapses.” <i>ELife</i>. eLife Sciences Publications, 2016. <a href=\"https://doi.org/10.7554/eLife.17977\">https://doi.org/10.7554/eLife.17977</a>.","ieee":"N. Vyleta, C. Borges Merjane, and P. M. Jonas, “Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses,” <i>eLife</i>, vol. 5. eLife Sciences Publications, 2016.","apa":"Vyleta, N., Borges Merjane, C., &#38; Jonas, P. M. (2016). Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.17977\">https://doi.org/10.7554/eLife.17977</a>","mla":"Vyleta, Nicholas, et al. “Plasticity-Dependent, Full Detonation at Hippocampal Mossy Fiber–CA3 Pyramidal Neuron Synapses.” <i>ELife</i>, vol. 5, e17977, eLife Sciences Publications, 2016, doi:<a href=\"https://doi.org/10.7554/eLife.17977\">10.7554/eLife.17977</a>.","ista":"Vyleta N, Borges Merjane C, Jonas PM. 2016. Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses. eLife. 5, e17977.","ama":"Vyleta N, Borges Merjane C, Jonas PM. Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses. <i>eLife</i>. 2016;5. doi:<a href=\"https://doi.org/10.7554/eLife.17977\">10.7554/eLife.17977</a>"},"oa":1,"publication_status":"published","has_accepted_license":"1","ddc":["571","572"],"date_published":"2016-10-25T00:00:00Z","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"PreCl"}],"publisher":"eLife Sciences Publications","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"PeJo"}],"publication":"eLife","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"scopus_import":1,"ec_funded":1,"author":[{"last_name":"Vyleta","first_name":"Nicholas","id":"36C4978E-F248-11E8-B48F-1D18A9856A87","full_name":"Vyleta, Nicholas"},{"orcid":"0000-0003-0005-401X","id":"4305C450-F248-11E8-B48F-1D18A9856A87","full_name":"Borges Merjane, Carolina","last_name":"Borges Merjane","first_name":"Carolina"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","first_name":"Peter M","last_name":"Jonas"}],"file":[{"file_size":1477891,"content_type":"application/pdf","relation":"main_file","creator":"system","file_name":"IST-2016-715-v1+1_e17977-download.pdf","date_created":"2018-12-12T10:17:05Z","access_level":"open_access","file_id":"5257","date_updated":"2020-07-14T12:44:44Z","checksum":"a7201280c571bed88ebd459ce5ce6a47"}],"day":"25","article_number":"e17977","title":"Plasticity-dependent, full detonation at hippocampal mossy fiber–CA3 pyramidal neuron synapses","publist_id":"5947","project":[{"grant_number":"268548","_id":"25C0F108-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Nanophysiology of fast-spiking, parvalbumin-expressing GABAergic interneurons"},{"grant_number":"692692","call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","name":"Biophysics and circuit function of a giant cortical glumatergic synapse"}],"language":[{"iso":"eng"}],"pubrep_id":"715","doi":"10.7554/eLife.17977","quality_controlled":"1"},{"date_created":"2018-12-11T11:51:23Z","file_date_updated":"2020-07-14T12:44:44Z","volume":59,"abstract":[{"text":"We study graphs and two-player games in which rewards are assigned to states, and the goal of the players is to satisfy or dissatisfy certain property of the generated outcome, given as a mean payoff property. Since the notion of mean-payoff does not reflect possible fluctuations from the mean-payoff along a run, we propose definitions and algorithms for capturing the stability of the system, and give algorithms for deciding if a given mean payoff and stability objective can be ensured in the system.","lang":"eng"}],"date_updated":"2021-01-12T06:49:53Z","month":"08","type":"conference","oa_version":"Published Version","_id":"1325","year":"2016","acknowledgement":"The work has been supported by the Czech Science Foundation, grant No. 15-17564S, by EPSRC grant\r\nEP/M023656/1, and by the People Programme (Marie Curie Actions) of the European Union’s Seventh\r\nFramework Programme (FP7/2007-2013) under REA grant agreement no [291734]","date_published":"2016-08-01T00:00:00Z","ddc":["004"],"has_accepted_license":"1","oa":1,"publication_status":"published","citation":{"ama":"Brázdil T, Forejt V, Kučera A, Novotný P. Stability in graphs and games. In: Vol 59. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2016. doi:<a href=\"https://doi.org/10.4230/LIPIcs.CONCUR.2016.10\">10.4230/LIPIcs.CONCUR.2016.10</a>","apa":"Brázdil, T., Forejt, V., Kučera, A., &#38; Novotný, P. (2016). Stability in graphs and games (Vol. 59). Presented at the CONCUR: Concurrency Theory, Quebec City, Canada: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.CONCUR.2016.10\">https://doi.org/10.4230/LIPIcs.CONCUR.2016.10</a>","mla":"Brázdil, Tomáš, et al. <i>Stability in Graphs and Games</i>. Vol. 59, 10, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016, doi:<a href=\"https://doi.org/10.4230/LIPIcs.CONCUR.2016.10\">10.4230/LIPIcs.CONCUR.2016.10</a>.","ista":"Brázdil T, Forejt V, Kučera A, Novotný P. 2016. Stability in graphs and games. CONCUR: Concurrency Theory, LIPIcs, vol. 59, 10.","chicago":"Brázdil, Tomáš, Vojtěch Forejt, Antonín Kučera, and Petr Novotný. “Stability in Graphs and Games,” Vol. 59. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016. <a href=\"https://doi.org/10.4230/LIPIcs.CONCUR.2016.10\">https://doi.org/10.4230/LIPIcs.CONCUR.2016.10</a>.","ieee":"T. Brázdil, V. Forejt, A. Kučera, and P. Novotný, “Stability in graphs and games,” presented at the CONCUR: Concurrency Theory, Quebec City, Canada, 2016, vol. 59.","short":"T. Brázdil, V. Forejt, A. Kučera, P. Novotný, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016."},"intvolume":"        59","status":"public","alternative_title":["LIPIcs"],"publist_id":"5944","title":"Stability in graphs and games","article_number":"10","file":[{"creator":"system","content_type":"application/pdf","relation":"main_file","file_size":553648,"file_name":"IST-2016-665-v1+1_Forejt_et_al__Stability_in_graphs_and_games.pdf","access_level":"open_access","date_created":"2018-12-12T10:16:40Z","checksum":"3c2dc6ab0358f8aa8f7aa7d6c1293159","date_updated":"2020-07-14T12:44:44Z","file_id":"5229"}],"day":"01","author":[{"full_name":"Brázdil, Tomáš","last_name":"Brázdil","first_name":"Tomáš"},{"full_name":"Forejt, Vojtěch","first_name":"Vojtěch","last_name":"Forejt"},{"last_name":"Kučera","first_name":"Antonín","full_name":"Kučera, Antonín"},{"last_name":"Novotny","first_name":"Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","full_name":"Novotny, Petr"}],"scopus_import":1,"ec_funded":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"KrCh"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","quality_controlled":"1","doi":"10.4230/LIPIcs.CONCUR.2016.10","pubrep_id":"665","language":[{"iso":"eng"}],"conference":{"location":"Quebec City, Canada","name":"CONCUR: Concurrency Theory","start_date":"2016-08-23","end_date":"2016-08-26"},"project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"}]},{"department":[{"_id":"KrCh"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Springer","ec_funded":1,"scopus_import":1,"day":"22","author":[{"first_name":"Tomáš","last_name":"Brázdil","full_name":"Brázdil, Tomáš"},{"last_name":"Kučera","first_name":"Antonín","full_name":"Kučera, Antonín"},{"last_name":"Novotny","first_name":"Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","full_name":"Novotny, Petr"}],"publist_id":"5943","title":"Optimizing the expected mean payoff in Energy Markov Decision Processes","project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"}],"language":[{"iso":"eng"}],"conference":{"start_date":"2016-10-17","name":"ATVA: Automated Technology for Verification and Analysis","location":"Chiba, Japan","end_date":"2016-10-20"},"quality_controlled":"1","doi":"10.1007/978-3-319-46520-3_3","year":"2016","acknowledgement":"The research was funded by the Czech Science Foundation Grant No. P202/12/G061 and by the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no [291734].","_id":"1326","type":"conference","oa_version":"Preprint","month":"09","date_updated":"2021-01-12T06:49:53Z","abstract":[{"text":"Energy Markov Decision Processes (EMDPs) are finite-state Markov decision processes where each transition is assigned an integer counter update and a rational payoff. An EMDP configuration is a pair s(n), where s is a control state and n is the current counter value. The configurations are changed by performing transitions in the standard way. We consider the problem of computing a safe strategy (i.e., a strategy that keeps the counter non-negative) which maximizes the expected mean payoff. ","lang":"eng"}],"page":"32 - 49","date_created":"2018-12-11T11:51:23Z","volume":9938,"status":"public","alternative_title":["LNCS"],"citation":{"apa":"Brázdil, T., Kučera, A., &#38; Novotný, P. (2016). Optimizing the expected mean payoff in Energy Markov Decision Processes (Vol. 9938, pp. 32–49). Presented at the ATVA: Automated Technology for Verification and Analysis, Chiba, Japan: Springer. <a href=\"https://doi.org/10.1007/978-3-319-46520-3_3\">https://doi.org/10.1007/978-3-319-46520-3_3</a>","mla":"Brázdil, Tomáš, et al. <i>Optimizing the Expected Mean Payoff in Energy Markov Decision Processes</i>. Vol. 9938, Springer, 2016, pp. 32–49, doi:<a href=\"https://doi.org/10.1007/978-3-319-46520-3_3\">10.1007/978-3-319-46520-3_3</a>.","ista":"Brázdil T, Kučera A, Novotný P. 2016. Optimizing the expected mean payoff in Energy Markov Decision Processes. ATVA: Automated Technology for Verification and Analysis, LNCS, vol. 9938, 32–49.","ama":"Brázdil T, Kučera A, Novotný P. Optimizing the expected mean payoff in Energy Markov Decision Processes. In: Vol 9938. Springer; 2016:32-49. doi:<a href=\"https://doi.org/10.1007/978-3-319-46520-3_3\">10.1007/978-3-319-46520-3_3</a>","short":"T. Brázdil, A. Kučera, P. Novotný, in:, Springer, 2016, pp. 32–49.","chicago":"Brázdil, Tomáš, Antonín Kučera, and Petr Novotný. “Optimizing the Expected Mean Payoff in Energy Markov Decision Processes,” 9938:32–49. Springer, 2016. <a href=\"https://doi.org/10.1007/978-3-319-46520-3_3\">https://doi.org/10.1007/978-3-319-46520-3_3</a>.","ieee":"T. Brázdil, A. Kučera, and P. Novotný, “Optimizing the expected mean payoff in Energy Markov Decision Processes,” presented at the ATVA: Automated Technology for Verification and Analysis, Chiba, Japan, 2016, vol. 9938, pp. 32–49."},"intvolume":"      9938","publication_status":"published","oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1607.00678","open_access":"1"}],"date_published":"2016-09-22T00:00:00Z"},{"_id":"1327","publication":"Proceedings of the 15th International Conference on Autonomous Agents and Multiagent Systems","ec_funded":1,"scopus_import":1,"publisher":"ACM","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","year":"2016","department":[{"_id":"KrCh"}],"title":"Stochastic shortest path with energy constraints in POMDPs","date_created":"2018-12-11T11:51:23Z","publist_id":"5942","page":"1465 - 1466","author":[{"last_name":"Brázdil","first_name":"Tomáš","full_name":"Brázdil, Tomáš"},{"last_name":"Chatterjee","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","orcid":"0000-0002-4561-241X","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Martin","last_name":"Chmelik","full_name":"Chmelik, Martin","id":"3624234E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Gupta, Anchit","last_name":"Gupta","first_name":"Anchit"},{"full_name":"Novotny, Petr","id":"3CC3B868-F248-11E8-B48F-1D18A9856A87","first_name":"Petr","last_name":"Novotny"}],"oa_version":"Preprint","month":"01","type":"conference","date_updated":"2021-01-12T06:49:54Z","day":"01","abstract":[{"text":"We consider partially observable Markov decision processes (POMDPs) with a set of target states and positive integer costs associated with every transition. The traditional optimization objective (stochastic shortest path) asks to minimize the expected total cost until the target set is reached. We extend the traditional framework of POMDPs to model energy consumption, which represents a hard constraint. The energy levels may increase and decrease with transitions, and the hard constraint requires that the energy level must remain positive in all steps till the target is reached. First, we present a novel algorithm for solving POMDPs with energy levels, developing on existing POMDP solvers and using RTDP as its main method. Our second contribution is related to policy representation. For larger POMDP instances the policies computed by existing solvers are too large to be understandable. We present an automated procedure based on machine learning techniques that automatically extracts important decisions of the policy allowing us to compute succinct human readable policies. Finally, we show experimentally that our algorithm performs well and computes succinct policies on a number of POMDP instances from the literature that were naturally enhanced with energy levels. ","lang":"eng"}],"conference":{"end_date":"2016-05-13","name":"AAMAS: Autonomous Agents & Multiagent Systems","location":"Singapore","start_date":"2016-05-09"},"citation":{"apa":"Brázdil, T., Chatterjee, K., Chmelik, M., Gupta, A., &#38; Novotný, P. (2016). Stochastic shortest path with energy constraints in POMDPs. In <i>Proceedings of the 15th International Conference on Autonomous Agents and Multiagent Systems</i> (pp. 1465–1466). Singapore: ACM.","ista":"Brázdil T, Chatterjee K, Chmelik M, Gupta A, Novotný P. 2016. Stochastic shortest path with energy constraints in POMDPs. Proceedings of the 15th International Conference on Autonomous Agents and Multiagent Systems. AAMAS: Autonomous Agents &#38; Multiagent Systems, 1465–1466.","mla":"Brázdil, Tomáš, et al. “Stochastic Shortest Path with Energy Constraints in POMDPs.” <i>Proceedings of the 15th International Conference on Autonomous Agents and Multiagent Systems</i>, ACM, 2016, pp. 1465–66.","ama":"Brázdil T, Chatterjee K, Chmelik M, Gupta A, Novotný P. Stochastic shortest path with energy constraints in POMDPs. In: <i>Proceedings of the 15th International Conference on Autonomous Agents and Multiagent Systems</i>. ACM; 2016:1465-1466.","short":"T. Brázdil, K. Chatterjee, M. Chmelik, A. Gupta, P. Novotný, in:, Proceedings of the 15th International Conference on Autonomous Agents and Multiagent Systems, ACM, 2016, pp. 1465–1466.","chicago":"Brázdil, Tomáš, Krishnendu Chatterjee, Martin Chmelik, Anchit Gupta, and Petr Novotný. “Stochastic Shortest Path with Energy Constraints in POMDPs.” In <i>Proceedings of the 15th International Conference on Autonomous Agents and Multiagent Systems</i>, 1465–66. ACM, 2016.","ieee":"T. Brázdil, K. Chatterjee, M. Chmelik, A. Gupta, and P. Novotný, “Stochastic shortest path with energy constraints in POMDPs,” in <i>Proceedings of the 15th International Conference on Autonomous Agents and Multiagent Systems</i>, Singapore, 2016, pp. 1465–1466."},"language":[{"iso":"eng"}],"project":[{"grant_number":"P 23499-N23","_id":"2584A770-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Modern Graph Algorithmic Techniques in Formal Verification"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23"},{"grant_number":"291734","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"_id":"2581B60A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Quantitative Graph Games: Theory and Applications","grant_number":"279307"}],"status":"public","date_published":"2016-01-01T00:00:00Z","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1602.07565"}],"publication_status":"published","oa":1},{"file_date_updated":"2020-07-14T12:44:44Z","date_created":"2018-12-11T11:51:24Z","volume":16,"type":"journal_article","month":"09","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Hole spins have gained considerable interest in the past few years due to their potential for fast electrically controlled qubits. Here, we study holes confined in Ge hut wires, a so-far unexplored type of nanostructure. Low-temperature magnetotransport measurements reveal a large anisotropy between the in-plane and out-of-plane g-factors of up to 18. Numerical simulations verify that this large anisotropy originates from a confined wave function of heavy-hole character. A light-hole admixture of less than 1% is estimated for the states of lowest energy, leading to a surprisingly large reduction of the out-of-plane g-factors compared with those for pure heavy holes. Given this tiny light-hole contribution, the spin lifetimes are expected to be very long, even in isotopically nonpurified samples."}],"date_updated":"2023-09-07T13:15:02Z","page":"6879 - 6885","_id":"1328","year":"2016","acknowledgement":"The work was supported by the EC FP7 ICT project SiSPIN no. 323841, the EC FP7 ICT project PAMS no. 610446, the ERC Starting Grant no. 335497, the FWF-I-1190-N20 project, and the Swiss NSF. We acknowledge F. Schäffler for fruitful discussions related to the hut wire growth and for giving us access to the molecular beam epitaxy system, M. Schatzl for her support in electron beam lithography, and V. Jadris ̌ko for helping us with the COMSOL simulations. Finally, we thank G. Bauer for his continuous support. ","date_published":"2016-09-22T00:00:00Z","ddc":["539"],"has_accepted_license":"1","publication_status":"published","oa":1,"citation":{"chicago":"Watzinger, Hannes, Christoph Kloeffel, Lada Vukušić, Marta Rossell, Violetta Sessi, Josip Kukucka, Raimund Kirchschlager, et al. “Heavy-Hole States in Germanium Hut Wires.” <i>Nano Letters</i>. American Chemical Society, 2016. <a href=\"https://doi.org/10.1021/acs.nanolett.6b02715\">https://doi.org/10.1021/acs.nanolett.6b02715</a>.","ieee":"H. Watzinger <i>et al.</i>, “Heavy-hole states in germanium hut wires,” <i>Nano Letters</i>, vol. 16, no. 11. American Chemical Society, pp. 6879–6885, 2016.","short":"H. Watzinger, C. Kloeffel, L. Vukušić, M. Rossell, V. Sessi, J. Kukucka, R. Kirchschlager, E. Lausecker, A. Truhlar, M. Glaser, A. Rastelli, A. Fuhrer, D. Loss, G. Katsaros, Nano Letters 16 (2016) 6879–6885.","ama":"Watzinger H, Kloeffel C, Vukušić L, et al. Heavy-hole states in germanium hut wires. <i>Nano Letters</i>. 2016;16(11):6879-6885. doi:<a href=\"https://doi.org/10.1021/acs.nanolett.6b02715\">10.1021/acs.nanolett.6b02715</a>","apa":"Watzinger, H., Kloeffel, C., Vukušić, L., Rossell, M., Sessi, V., Kukucka, J., … Katsaros, G. (2016). Heavy-hole states in germanium hut wires. <i>Nano Letters</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.nanolett.6b02715\">https://doi.org/10.1021/acs.nanolett.6b02715</a>","ista":"Watzinger H, Kloeffel C, Vukušić L, Rossell M, Sessi V, Kukucka J, Kirchschlager R, Lausecker E, Truhlar A, Glaser M, Rastelli A, Fuhrer A, Loss D, Katsaros G. 2016. Heavy-hole states in germanium hut wires. Nano Letters. 16(11), 6879–6885.","mla":"Watzinger, Hannes, et al. “Heavy-Hole States in Germanium Hut Wires.” <i>Nano Letters</i>, vol. 16, no. 11, American Chemical Society, 2016, pp. 6879–85, doi:<a href=\"https://doi.org/10.1021/acs.nanolett.6b02715\">10.1021/acs.nanolett.6b02715</a>."},"related_material":{"record":[{"id":"7977","status":"for_moderation","relation":"popular_science"},{"id":"7996","status":"public","relation":"dissertation_contains"}]},"intvolume":"        16","status":"public","publist_id":"5941","title":"Heavy-hole states in germanium hut wires","day":"22","file":[{"creator":"system","file_size":535121,"content_type":"application/pdf","relation":"main_file","file_name":"IST-2016-664-v1+1_acs.nanolett.6b02715.pdf","access_level":"open_access","date_created":"2018-12-12T10:14:04Z","checksum":"b63feece90d7b620ece49ca632e34ff3","file_id":"5053","date_updated":"2020-07-14T12:44:44Z"}],"author":[{"first_name":"Hannes","last_name":"Watzinger","full_name":"Watzinger, Hannes","id":"35DF8E50-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kloeffel","first_name":"Christoph","full_name":"Kloeffel, Christoph"},{"last_name":"Vukusic","first_name":"Lada","orcid":"0000-0003-2424-8636","id":"31E9F056-F248-11E8-B48F-1D18A9856A87","full_name":"Vukusic, Lada"},{"full_name":"Rossell, Marta","first_name":"Marta","last_name":"Rossell"},{"full_name":"Sessi, Violetta","last_name":"Sessi","first_name":"Violetta"},{"full_name":"Kukucka, Josip","id":"3F5D8856-F248-11E8-B48F-1D18A9856A87","first_name":"Josip","last_name":"Kukucka"},{"full_name":"Kirchschlager, Raimund","first_name":"Raimund","last_name":"Kirchschlager"},{"first_name":"Elisabeth","last_name":"Lausecker","id":"33662F76-F248-11E8-B48F-1D18A9856A87","full_name":"Lausecker, Elisabeth"},{"first_name":"Alisha","last_name":"Truhlar","full_name":"Truhlar, Alisha","id":"49CBC780-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Glaser, Martin","last_name":"Glaser","first_name":"Martin"},{"first_name":"Armando","last_name":"Rastelli","full_name":"Rastelli, Armando"},{"last_name":"Fuhrer","first_name":"Andreas","full_name":"Fuhrer, Andreas"},{"last_name":"Loss","first_name":"Daniel","full_name":"Loss, Daniel"},{"first_name":"Georgios","last_name":"Katsaros","orcid":"0000-0001-8342-202X","id":"38DB5788-F248-11E8-B48F-1D18A9856A87","full_name":"Katsaros, Georgios"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ec_funded":1,"scopus_import":1,"publication":"Nano Letters","department":[{"_id":"GeKa"}],"publisher":"American Chemical Society","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","doi":"10.1021/acs.nanolett.6b02715","pubrep_id":"664","issue":"11","language":[{"iso":"eng"}],"project":[{"name":"Towards Spin qubits and Majorana fermions in Germanium selfassembled hut-wires","_id":"25517E86-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"335497"}]},{"_id":"1329","year":"2016","acknowledgement":"This study was financially supported by individual grants from the Volkswagen Stiftung (to M.C.), the Deutsche Forschungsgemeinschaft (grant PA 903/6 to J.P.) and the DAAD (to A.K.H.). The authors would like to thank I. Schrank, L. Theodosiou, M. Kredler, C. Laforsch, J. Wolinska, J. Griebel, R. Jaenichen, and K. Otte for providing the necessary resources and help for maintaining Daphnia cultures in the laboratory. H. Lainer supported us for the molecular laboratory work. D. Gilbert and J. K. Colbourne contributed ideas for the bioinformatics analysis, and L. Hardulak did the orthology mapping including more insect species. This study was financially supported by individual grants from the Volkswagen Stiftung (to M.C.), the Deutsche Forschungsgemeinschaft (grant PA 903/6 to J.P.) and the DAAD (to A.K.H.). This work benefits from and contributes to the Daphnia Genomics Consortium.","file_date_updated":"2020-07-14T12:44:44Z","date_created":"2018-12-11T11:51:24Z","volume":8,"date_updated":"2021-01-12T06:49:55Z","abstract":[{"lang":"eng","text":"Daphnia species have become models for ecological genomics and exhibit interesting features, such as high phenotypic plasticity and a densely packed genome with many lineage-specific genes. They are also cyclic parthenogenetic, with alternating asexual and sexual cycles and environmental sex determination. Here, we present a de novo transcriptome assembly of over 32,000 D. galeata genes and use it to investigate gene expression in females and spontaneously produced males of two clonal lines derived from lakes in Germany and the Czech Republic. We find that only a low percentage (18%) of genes shows sex-biased expression and that there are many more female-biased gene (FBG) than male-biased gene (MBG). Furthermore, FBGs tend to be more conserved between species than MBGs in both sequence and expression. These patterns may be a consequence of cyclic parthenogenesis leading to a relaxation of purifying selection on MBGs. The two clonal lines show considerable differences in both number and identity of sex-biased genes, suggesting that they may have reproductive strategies differing in their investment in sexual reproduction. Orthologs of key genes in the sex determination and juvenile hormone pathways, which are thought to be important for the transition from asexual to sexual reproduction, are present in D. galeata and highly conserved among Daphnia species."}],"month":"10","oa_version":"Published Version","type":"journal_article","page":"3120 - 3139","citation":{"mla":"Huylmans, Ann K., et al. “De Novo Transcriptome Assembly and Sex-Biased Gene Expression in the Cyclical Parthenogenetic Daphnia Galeata.” <i>Genome Biology and Evolution</i>, vol. 8, no. 10, Oxford University Press, 2016, pp. 3120–39, doi:<a href=\"https://doi.org/10.1093/gbe/evw221\">10.1093/gbe/evw221</a>.","ista":"Huylmans AK, López Ezquerra A, Parsch J, Cordellier M. 2016. De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata. Genome Biology and Evolution. 8(10), 3120–3139.","apa":"Huylmans, A. K., López Ezquerra, A., Parsch, J., &#38; Cordellier, M. (2016). De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata. <i>Genome Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/gbe/evw221\">https://doi.org/10.1093/gbe/evw221</a>","ama":"Huylmans AK, López Ezquerra A, Parsch J, Cordellier M. De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata. <i>Genome Biology and Evolution</i>. 2016;8(10):3120-3139. doi:<a href=\"https://doi.org/10.1093/gbe/evw221\">10.1093/gbe/evw221</a>","short":"A.K. Huylmans, A. López Ezquerra, J. Parsch, M. Cordellier, Genome Biology and Evolution 8 (2016) 3120–3139.","ieee":"A. K. Huylmans, A. López Ezquerra, J. Parsch, and M. Cordellier, “De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata,” <i>Genome Biology and Evolution</i>, vol. 8, no. 10. Oxford University Press, pp. 3120–3139, 2016.","chicago":"Huylmans, Ann K, Alberto López Ezquerra, John Parsch, and Mathilde Cordellier. “De Novo Transcriptome Assembly and Sex-Biased Gene Expression in the Cyclical Parthenogenetic Daphnia Galeata.” <i>Genome Biology and Evolution</i>. Oxford University Press, 2016. <a href=\"https://doi.org/10.1093/gbe/evw221\">https://doi.org/10.1093/gbe/evw221</a>."},"intvolume":"         8","status":"public","date_published":"2016-10-01T00:00:00Z","ddc":["576"],"has_accepted_license":"1","publication_status":"published","oa":1,"scopus_import":1,"tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"publication":"Genome Biology and Evolution","department":[{"_id":"BeVi"}],"publisher":"Oxford University Press","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publist_id":"5940","title":"De novo transcriptome assembly and sex-biased gene expression in the cyclical parthenogenetic Daphnia galeata","license":"https://creativecommons.org/licenses/by-nc/4.0/","file":[{"checksum":"25c7adcb452d39d3b6343ff4b57a652d","file_id":"4924","date_updated":"2020-07-14T12:44:44Z","access_level":"open_access","date_created":"2018-12-12T10:12:06Z","file_name":"IST-2016-663-v1+1_Genome_Biol_Evol-2016-Huylmans-3120-39.pdf","creator":"system","file_size":1406265,"content_type":"application/pdf","relation":"main_file"}],"day":"01","author":[{"full_name":"Huylmans, Ann K","id":"4C0A3874-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8871-4961","first_name":"Ann K","last_name":"Huylmans"},{"full_name":"López Ezquerra, Alberto","first_name":"Alberto","last_name":"López Ezquerra"},{"first_name":"John","last_name":"Parsch","full_name":"Parsch, John"},{"full_name":"Cordellier, Mathilde","first_name":"Mathilde","last_name":"Cordellier"}],"language":[{"iso":"eng"}],"issue":"10","quality_controlled":"1","doi":"10.1093/gbe/evw221","pubrep_id":"663"},{"ec_funded":1,"scopus_import":1,"publication":"Israel Journal of Mathematics","department":[{"_id":"HeEd"}],"publisher":"Springer","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publist_id":"5938","title":"Billiards in convex bodies with acute angles","day":"15","author":[{"last_name":"Akopyan","first_name":"Arseniy","orcid":"0000-0002-2548-617X","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","full_name":"Akopyan, Arseniy"},{"full_name":"Balitskiy, Alexey","first_name":"Alexey","last_name":"Balitskiy"}],"language":[{"iso":"eng"}],"issue":"2","project":[{"name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"291734"}],"quality_controlled":"1","doi":"10.1007/s11856-016-1429-z","_id":"1330","year":"2016","acknowledgement":"Supported by People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement n°[291734]. Supported by the Russian Foundation for Basic Research grant 15-31-20403 (mol a ved), by the Russian Foundation for Basic Research grant 15-01-99563 A, in part by the Moebius Contest Foundation for Young Scientists, and in part by the Simons Foundation.","date_created":"2018-12-11T11:51:24Z","volume":216,"abstract":[{"lang":"eng","text":"In this paper we investigate the existence of closed billiard trajectories in not necessarily smooth convex bodies. In particular, we show that if a body K ⊂ Rd has the property that the tangent cone of every non-smooth point q ∉ ∂K is acute (in a certain sense), then there is a closed billiard trajectory in K."}],"date_updated":"2021-01-12T06:49:56Z","type":"journal_article","oa_version":"Preprint","month":"10","page":"833 - 845","citation":{"ista":"Akopyan A, Balitskiy A. 2016. Billiards in convex bodies with acute angles. Israel Journal of Mathematics. 216(2), 833–845.","mla":"Akopyan, Arseniy, and Alexey Balitskiy. “Billiards in Convex Bodies with Acute Angles.” <i>Israel Journal of Mathematics</i>, vol. 216, no. 2, Springer, 2016, pp. 833–45, doi:<a href=\"https://doi.org/10.1007/s11856-016-1429-z\">10.1007/s11856-016-1429-z</a>.","apa":"Akopyan, A., &#38; Balitskiy, A. (2016). Billiards in convex bodies with acute angles. <i>Israel Journal of Mathematics</i>. Springer. <a href=\"https://doi.org/10.1007/s11856-016-1429-z\">https://doi.org/10.1007/s11856-016-1429-z</a>","ama":"Akopyan A, Balitskiy A. Billiards in convex bodies with acute angles. <i>Israel Journal of Mathematics</i>. 2016;216(2):833-845. doi:<a href=\"https://doi.org/10.1007/s11856-016-1429-z\">10.1007/s11856-016-1429-z</a>","short":"A. Akopyan, A. Balitskiy, Israel Journal of Mathematics 216 (2016) 833–845.","ieee":"A. Akopyan and A. Balitskiy, “Billiards in convex bodies with acute angles,” <i>Israel Journal of Mathematics</i>, vol. 216, no. 2. Springer, pp. 833–845, 2016.","chicago":"Akopyan, Arseniy, and Alexey Balitskiy. “Billiards in Convex Bodies with Acute Angles.” <i>Israel Journal of Mathematics</i>. Springer, 2016. <a href=\"https://doi.org/10.1007/s11856-016-1429-z\">https://doi.org/10.1007/s11856-016-1429-z</a>."},"intvolume":"       216","status":"public","main_file_link":[{"url":"https://arxiv.org/abs/1506.06014","open_access":"1"}],"date_published":"2016-10-15T00:00:00Z","publication_status":"published","oa":1},{"doi":"10.1104/pp.16.00415","quality_controlled":"1","publication_identifier":{"eissn":["1532-2548"],"issn":["0032-0889"]},"issue":"2","language":[{"iso":"eng"}],"title":"Cytokinin response factor 6 represses cytokinin-associated genes during oxidative stress","publist_id":"5937","author":[{"full_name":"Zwack, Paul","first_name":"Paul","last_name":"Zwack"},{"full_name":"De Clercq, Inge","last_name":"De Clercq","first_name":"Inge"},{"first_name":"Timothy","last_name":"Howton","full_name":"Howton, Timothy"},{"full_name":"Hallmark, H Tucker","first_name":"H Tucker","last_name":"Hallmark"},{"id":"4DC4AF46-F248-11E8-B48F-1D18A9856A87","full_name":"Hurny, Andrej","last_name":"Hurny","first_name":"Andrej"},{"first_name":"Erika","last_name":"Keshishian","full_name":"Keshishian, Erika"},{"full_name":"Parish, Alyssa","last_name":"Parish","first_name":"Alyssa"},{"last_name":"Benková","first_name":"Eva","orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Benková, Eva"},{"full_name":"Mukhtar, M Shahid","first_name":"M Shahid","last_name":"Mukhtar"},{"first_name":"Frank","last_name":"Van Breusegem","full_name":"Van Breusegem, Frank"},{"full_name":"Rashotte, Aaron","last_name":"Rashotte","first_name":"Aaron"}],"day":"02","publication":"Plant Physiology","article_type":"original","article_processing_charge":"No","scopus_import":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"American Society of Plant Biologists","department":[{"_id":"EvBe"}],"date_published":"2016-10-02T00:00:00Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1104/pp.16.00415"}],"publication_status":"published","oa":1,"intvolume":"       172","citation":{"short":"P. Zwack, I. De Clercq, T. Howton, H.T. Hallmark, A. Hurny, E. Keshishian, A. Parish, E. Benková, M.S. Mukhtar, F. Van Breusegem, A. Rashotte, Plant Physiology 172 (2016) 1249–1258.","ieee":"P. Zwack <i>et al.</i>, “Cytokinin response factor 6 represses cytokinin-associated genes during oxidative stress,” <i>Plant Physiology</i>, vol. 172, no. 2. American Society of Plant Biologists, pp. 1249–1258, 2016.","chicago":"Zwack, Paul, Inge De Clercq, Timothy Howton, H Tucker Hallmark, Andrej Hurny, Erika Keshishian, Alyssa Parish, et al. “Cytokinin Response Factor 6 Represses Cytokinin-Associated Genes during Oxidative Stress.” <i>Plant Physiology</i>. American Society of Plant Biologists, 2016. <a href=\"https://doi.org/10.1104/pp.16.00415\">https://doi.org/10.1104/pp.16.00415</a>.","ista":"Zwack P, De Clercq I, Howton T, Hallmark HT, Hurny A, Keshishian E, Parish A, Benková E, Mukhtar MS, Van Breusegem F, Rashotte A. 2016. Cytokinin response factor 6 represses cytokinin-associated genes during oxidative stress. Plant Physiology. 172(2), 1249–1258.","mla":"Zwack, Paul, et al. “Cytokinin Response Factor 6 Represses Cytokinin-Associated Genes during Oxidative Stress.” <i>Plant Physiology</i>, vol. 172, no. 2, American Society of Plant Biologists, 2016, pp. 1249–58, doi:<a href=\"https://doi.org/10.1104/pp.16.00415\">10.1104/pp.16.00415</a>.","apa":"Zwack, P., De Clercq, I., Howton, T., Hallmark, H. T., Hurny, A., Keshishian, E., … Rashotte, A. (2016). Cytokinin response factor 6 represses cytokinin-associated genes during oxidative stress. <i>Plant Physiology</i>. American Society of Plant Biologists. <a href=\"https://doi.org/10.1104/pp.16.00415\">https://doi.org/10.1104/pp.16.00415</a>","ama":"Zwack P, De Clercq I, Howton T, et al. Cytokinin response factor 6 represses cytokinin-associated genes during oxidative stress. <i>Plant Physiology</i>. 2016;172(2):1249-1258. doi:<a href=\"https://doi.org/10.1104/pp.16.00415\">10.1104/pp.16.00415</a>"},"status":"public","volume":172,"date_created":"2018-12-11T11:51:25Z","page":"1249 - 1258","oa_version":"Published Version","type":"journal_article","month":"10","date_updated":"2022-05-24T09:26:03Z","abstract":[{"lang":"eng","text":"Cytokinin is a phytohormone that is well known for its roles in numerous plant growth and developmental processes, yet it has also been linked to abiotic stress response in a less defined manner. Arabidopsis (Arabidopsis thaliana) Cytokinin Response Factor 6 (CRF6) is a cytokinin-responsive AP2/ERF-family transcription factor that, through the cytokinin signaling pathway, plays a key role in the inhibition of dark-induced senescence. CRF6 expression is also induced by oxidative stress, and here we show a novel function for CRF6 in relation to oxidative stress and identify downstream transcriptional targets of CRF6 that are repressed in response to oxidative stress. Analysis of transcriptomic changes in wild-type and crf6 mutant plants treated with H2O2 identified CRF6-dependent differentially expressed transcripts, many of which were repressed rather than induced. Moreover, many repressed genes also show decreased expression in 35S:CRF6 overexpressing plants. Together, these findings suggest that CRF6 functions largely as a transcriptional repressor. Interestingly, among the H2O2 repressed CRF6-dependent transcripts was a set of five genes associated with cytokinin processes: (signaling) ARR6, ARR9, ARR11, (biosynthesis) LOG7, and (transport) ABCG14. We have examined mutants of these cytokinin-associated target genes to reveal novel connections to oxidative stress. Further examination of CRF6-DNA interactions indicated that CRF6 may regulate its targets both directly and indirectly. Together, this shows that CRF6 functions during oxidative stress as a negative regulator to control this cytokinin-associated module of CRF6- dependent genes and establishes a novel connection between cytokinin and oxidative stress response."}],"_id":"1331","acknowledgement":"This work was financially supported by the following: The Alabama Agricultural Experiment Station HATCH grants 370222-310010-2055 and 370225-310006-2055 for funding to P.J.Z., E.A.K, A.M.P., and A.M.R. P.J.Z. and E.A.K were supported by an Auburn University Cellular and Molecular Biosciences Research Fellowship. I.D.C. is a postdoctoral fellow of the Research Foundation Flanders (FWO) (FWO/PDO14/043) and is also supported by FWO travel\r\ngrant 12N2415N. F.V.B. was supported by grants from the Interuniversity Attraction Poles Programme (IUAP P7/29 MARS) initiated by the Belgian Science Policy Office and Ghent University (Multidisciplinary Research Partnership Biotechnology for a Sustainable Economy, grant 01MRB510W).","year":"2016"},{"year":"2016","acknowledgement":"This work was partially supported by US National Institutes of Health grant R01-GM081617, Israeli Centers of Research Excellence I-CORE Program ISF Grant No. 152/11, and the European Research Council FP7 ERC Grant 281891.","_id":"1332","month":"01","oa_version":"Published Version","type":"journal_article","abstract":[{"text":"Antibiotic-sensitive and -resistant bacteria coexist in natural environments with low, if detectable, antibiotic concentrations. Except possibly around localized antibiotic sources, where resistance can provide a strong advantage, bacterial fitness is dominated by stresses unaffected by resistance to the antibiotic. How do such mixed and heterogeneous conditions influence the selective advantage or disadvantage of antibiotic resistance? Here we find that sub-inhibitory levels of tetracyclines potentiate selection for or against tetracycline resistance around localized sources of almost any toxin or stress. Furthermore, certain stresses generate alternating rings of selection for and against resistance around a localized source of the antibiotic. In these conditions, localized antibiotic sources, even at high strengths, can actually produce a net selection against resistance to the antibiotic. Our results show that interactions between the effects of an antibiotic and other stresses in inhomogeneous environments can generate pervasive, complex patterns of selection both for and against antibiotic resistance.","lang":"eng"}],"date_updated":"2021-01-12T06:49:57Z","date_created":"2018-12-11T11:51:25Z","file_date_updated":"2020-07-14T12:44:44Z","volume":7,"status":"public","citation":{"ama":"Chait RP, Palmer A, Yelin I, Kishony R. Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments. <i>Nature Communications</i>. 2016;7. doi:<a href=\"https://doi.org/10.1038/ncomms10333\">10.1038/ncomms10333</a>","apa":"Chait, R. P., Palmer, A., Yelin, I., &#38; Kishony, R. (2016). Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms10333\">https://doi.org/10.1038/ncomms10333</a>","ista":"Chait RP, Palmer A, Yelin I, Kishony R. 2016. Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments. Nature Communications. 7, 10333.","mla":"Chait, Remy P., et al. “Pervasive Selection for and against Antibiotic Resistance in Inhomogeneous Multistress Environments.” <i>Nature Communications</i>, vol. 7, 10333, Nature Publishing Group, 2016, doi:<a href=\"https://doi.org/10.1038/ncomms10333\">10.1038/ncomms10333</a>.","chicago":"Chait, Remy P, Adam Palmer, Idan Yelin, and Roy Kishony. “Pervasive Selection for and against Antibiotic Resistance in Inhomogeneous Multistress Environments.” <i>Nature Communications</i>. Nature Publishing Group, 2016. <a href=\"https://doi.org/10.1038/ncomms10333\">https://doi.org/10.1038/ncomms10333</a>.","ieee":"R. P. Chait, A. Palmer, I. Yelin, and R. Kishony, “Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments,” <i>Nature Communications</i>, vol. 7. Nature Publishing Group, 2016.","short":"R.P. Chait, A. Palmer, I. Yelin, R. Kishony, Nature Communications 7 (2016)."},"intvolume":"         7","has_accepted_license":"1","oa":1,"publication_status":"published","ddc":["570","579"],"date_published":"2016-01-20T00:00:00Z","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Nature Publishing Group","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"scopus_import":1,"publication":"Nature Communications","day":"20","file":[{"checksum":"ef147bcbb8bd37e9079cf3ce06f5815d","file_id":"5039","date_updated":"2020-07-14T12:44:44Z","access_level":"open_access","date_created":"2018-12-12T10:13:52Z","file_name":"IST-2016-662-v1+1_ncomms10333.pdf","creator":"system","file_size":1844107,"relation":"main_file","content_type":"application/pdf"}],"author":[{"full_name":"Chait, Remy P","id":"3464AE84-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0876-3187","last_name":"Chait","first_name":"Remy P"},{"last_name":"Palmer","first_name":"Adam","full_name":"Palmer, Adam"},{"last_name":"Yelin","first_name":"Idan","full_name":"Yelin, Idan"},{"last_name":"Kishony","first_name":"Roy","full_name":"Kishony, Roy"}],"publist_id":"5936","article_number":"10333","title":"Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments","language":[{"iso":"eng"}],"pubrep_id":"662","quality_controlled":"1","doi":"10.1038/ncomms10333"}]