[{"abstract":[{"lang":"ger","text":"Optogenetik und Photopharmakologie ermöglichen präzise räumliche und zeitliche Kontrolle von Proteinwechselwirkung und -funktion in Zellen und Tieren. Optogenetische Methoden, die auf grünes Licht ansprechen und zum Trennen von Proteinkomplexen geeignet sind, sind nichtweitläufig verfügbar, würden jedoch mehrfarbige Experimente zur Beantwortung von biologischen Fragestellungen ermöglichen. Hier demonstrieren wir die Verwendung von Cobalamin(Vitamin B12)-bindenden Domänen von bakteriellen CarH-Transkriptionsfaktoren zur Grünlicht-induzierten Dissoziation von Rezeptoren. Fusioniert mit dem Fibroblasten-W achstumsfaktor-Rezeptor 1 führten diese im Dunkeln in kultivierten Zellen zu Signalaktivität durch Oligomerisierung, welche durch Beleuchten umgehend aufgehoben wurde. In Zebrafischembryonen, die einen derartigen Rezeptor exprimieren, ermöglichte grünes Licht die Kontrolle über abnormale Signalaktivität während der Embryonalentwicklung. "}],"date_created":"2018-12-11T11:47:02Z","volume":129,"language":[{"iso":"eng"}],"oa":1,"date_updated":"2021-01-12T08:01:33Z","day":"20","pubrep_id":"932","_id":"538","publisher":"Wiley","citation":{"short":"S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.","ama":"Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. <i>Angewandte Chemie</i>. 2017;129(16):4679-4682. doi:<a href=\"https://doi.org/10.1002/ange.201611998\">10.1002/ange.201611998</a>","apa":"Kainrath, S., Stadler, M., Gschaider-Reichhart, E., Distel, M., &#38; Janovjak, H. L. (2017). Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. <i>Angewandte Chemie</i>. Wiley. <a href=\"https://doi.org/10.1002/ange.201611998\">https://doi.org/10.1002/ange.201611998</a>","ieee":"S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, and H. L. Janovjak, “Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen,” <i>Angewandte Chemie</i>, vol. 129, no. 16. Wiley, pp. 4679–4682, 2017.","chicago":"Kainrath, Stephanie, Manuela Stadler, Eva Gschaider-Reichhart, Martin Distel, and Harald L Janovjak. “Grünlicht-Induzierte Rezeptorinaktivierung Durch Cobalamin-Bindende Domänen.” <i>Angewandte Chemie</i>. Wiley, 2017. <a href=\"https://doi.org/10.1002/ange.201611998\">https://doi.org/10.1002/ange.201611998</a>.","ista":"Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. 2017. Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen. Angewandte Chemie. 129(16), 4679–4682.","mla":"Kainrath, Stephanie, et al. “Grünlicht-Induzierte Rezeptorinaktivierung Durch Cobalamin-Bindende Domänen.” <i>Angewandte Chemie</i>, vol. 129, no. 16, Wiley, 2017, pp. 4679–82, doi:<a href=\"https://doi.org/10.1002/ange.201611998\">10.1002/ange.201611998</a>."},"department":[{"_id":"CaGu"},{"_id":"HaJa"}],"title":"Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen","status":"public","page":"4679 - 4682","publist_id":"7279","type":"journal_article","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ec_funded":1,"file_date_updated":"2020-07-14T12:46:39Z","issue":"16","date_published":"2017-05-20T00:00:00Z","publication":"Angewandte Chemie","intvolume":"       129","author":[{"last_name":"Kainrath","id":"32CFBA64-F248-11E8-B48F-1D18A9856A87","full_name":"Kainrath, Stephanie","first_name":"Stephanie"},{"last_name":"Stadler","full_name":"Stadler, Manuela","first_name":"Manuela"},{"last_name":"Gschaider-Reichhart","id":"3FEE232A-F248-11E8-B48F-1D18A9856A87","full_name":"Gschaider-Reichhart, Eva","first_name":"Eva","orcid":"0000-0002-7218-7738"},{"first_name":"Martin","full_name":"Distel, Martin","last_name":"Distel"},{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","last_name":"Janovjak","first_name":"Harald L","orcid":"0000-0002-8023-9315","full_name":"Janovjak, Harald L"}],"month":"05","quality_controlled":"1","ddc":["571"],"year":"2017","file":[{"creator":"system","file_name":"IST-2018-932-v1+1_Kainrath_et_al-2017-Angewandte_Chemie.pdf","date_created":"2018-12-12T10:13:24Z","access_level":"open_access","relation":"main_file","file_id":"5007","date_updated":"2020-07-14T12:46:39Z","content_type":"application/pdf","checksum":"d66fee867e7cdbfa3fe276c2fb0778bb","file_size":1668557}],"has_accepted_license":"1","doi":"10.1002/ange.201611998","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_status":"published","oa_version":"Published Version","project":[{"name":"Microbial Ion Channels for Synthetic Neurobiology","grant_number":"303564","call_identifier":"FP7","_id":"25548C20-B435-11E9-9278-68D0E5697425"},{"_id":"255A6082-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"W1232-B24","name":"Molecular Drug Targets"}]},{"abstract":[{"lang":"eng","text":"We show that a non-singular integral form of degree d is soluble over the integers if and only if it is soluble over ℝ and over ℚp for all primes p, provided that the form has at least (d - 1/2 √d)2d variables. This improves on a longstanding result of Birch."}],"volume":2017,"date_created":"2018-12-11T11:45:28Z","language":[{"iso":"eng"}],"oa":1,"date_updated":"2024-03-05T12:09:21Z","article_type":"original","main_file_link":[{"url":"https://arxiv.org/abs/1402.4489","open_access":"1"}],"_id":"256","publisher":"Walter de Gruyter","day":"01","citation":{"apa":"Browning, T. D., &#38; Prendiville, S. (2017). Improvements in Birch’s theorem on forms in many variables. <i>Journal Fur Die Reine Und Angewandte Mathematik</i>. Walter de Gruyter. <a href=\"https://doi.org/10.1515/crelle-2014-0122\">https://doi.org/10.1515/crelle-2014-0122</a>","ama":"Browning TD, Prendiville S. Improvements in Birch’s theorem on forms in many variables. <i>Journal fur die Reine und Angewandte Mathematik</i>. 2017;2017(731):122. doi:<a href=\"https://doi.org/10.1515/crelle-2014-0122\">10.1515/crelle-2014-0122</a>","short":"T.D. Browning, S. Prendiville, Journal Fur Die Reine Und Angewandte Mathematik 2017 (2017) 122.","ista":"Browning TD, Prendiville S. 2017. Improvements in Birch’s theorem on forms in many variables. Journal fur die Reine und Angewandte Mathematik. 2017(731), 122.","mla":"Browning, Timothy D., and Sean Prendiville. “Improvements in Birch’s Theorem on Forms in Many Variables.” <i>Journal Fur Die Reine Und Angewandte Mathematik</i>, vol. 2017, no. 731, Walter de Gruyter, 2017, p. 122, doi:<a href=\"https://doi.org/10.1515/crelle-2014-0122\">10.1515/crelle-2014-0122</a>.","chicago":"Browning, Timothy D, and Sean Prendiville. “Improvements in Birch’s Theorem on Forms in Many Variables.” <i>Journal Fur Die Reine Und Angewandte Mathematik</i>. Walter de Gruyter, 2017. <a href=\"https://doi.org/10.1515/crelle-2014-0122\">https://doi.org/10.1515/crelle-2014-0122</a>.","ieee":"T. D. Browning and S. Prendiville, “Improvements in Birch’s theorem on forms in many variables,” <i>Journal fur die Reine und Angewandte Mathematik</i>, vol. 2017, no. 731. Walter de Gruyter, p. 122, 2017."},"page":"122","publication_identifier":{"issn":["0075-4102"]},"title":"Improvements in Birch's theorem on forms in many variables","status":"public","type":"journal_article","publist_id":"7646","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"731","acknowledgement":"While working on this paper the authors were supported by the Leverhulme Trust and ERC grant 306457.","arxiv":1,"date_published":"2017-10-01T00:00:00Z","external_id":{"arxiv":["1402.4489"]},"publication":"Journal fur die Reine und Angewandte Mathematik","extern":"1","intvolume":"      2017","author":[{"id":"35827D50-F248-11E8-B48F-1D18A9856A87","last_name":"Browning","orcid":"0000-0002-8314-0177","first_name":"Timothy D","full_name":"Browning, Timothy D"},{"last_name":"Prendiville","full_name":"Prendiville, Sean","first_name":"Sean"}],"month":"10","quality_controlled":"1","related_material":{"record":[{"relation":"earlier_version","status":"public","id":"271"}]},"year":"2017","doi":"10.1515/crelle-2014-0122","publication_status":"published","article_processing_charge":"No","oa_version":"Preprint"},{"oa_version":"Preprint","article_processing_charge":"No","publication_status":"published","doi":"10.2140/ant.2017.11.1657","year":"2017","quality_controlled":"1","author":[{"first_name":"Timothy D","full_name":"Browning, Timothy D","orcid":"0000-0002-8314-0177","last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Vishe, Pankaj","first_name":"Pankaj","last_name":"Vishe"}],"intvolume":"        11","month":"09","extern":"1","external_id":{"arxiv":["1611.00553"]},"publication":"Geometric Methods in Algebra and Number Theory","date_published":"2017-09-07T00:00:00Z","arxiv":1,"acknowledgement":"While working on this paper the first author was supported by ERC grant 306457.","issue":"7","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","publist_id":"7637","status":"public","publication_identifier":{"eissn":["1944-7833"]},"title":"Rational curves on smooth hypersurfaces of low degree","page":"1657 - 1675","citation":{"ieee":"T. D. Browning and P. Vishe, “Rational curves on smooth hypersurfaces of low degree,” <i>Geometric Methods in Algebra and Number Theory</i>, vol. 11, no. 7.  Mathematical Sciences Publishers, pp. 1657–1675, 2017.","mla":"Browning, Timothy D., and Pankaj Vishe. “Rational Curves on Smooth Hypersurfaces of Low Degree.” <i>Geometric Methods in Algebra and Number Theory</i>, vol. 11, no. 7,  Mathematical Sciences Publishers, 2017, pp. 1657–75, doi:<a href=\"https://doi.org/10.2140/ant.2017.11.1657\">10.2140/ant.2017.11.1657</a>.","ista":"Browning TD, Vishe P. 2017. Rational curves on smooth hypersurfaces of low degree. Geometric Methods in Algebra and Number Theory. 11(7), 1657–1675.","chicago":"Browning, Timothy D, and Pankaj Vishe. “Rational Curves on Smooth Hypersurfaces of Low Degree.” <i>Geometric Methods in Algebra and Number Theory</i>.  Mathematical Sciences Publishers, 2017. <a href=\"https://doi.org/10.2140/ant.2017.11.1657\">https://doi.org/10.2140/ant.2017.11.1657</a>.","short":"T.D. Browning, P. Vishe, Geometric Methods in Algebra and Number Theory 11 (2017) 1657–1675.","ama":"Browning TD, Vishe P. Rational curves on smooth hypersurfaces of low degree. <i>Geometric Methods in Algebra and Number Theory</i>. 2017;11(7):1657-1675. doi:<a href=\"https://doi.org/10.2140/ant.2017.11.1657\">10.2140/ant.2017.11.1657</a>","apa":"Browning, T. D., &#38; Vishe, P. (2017). Rational curves on smooth hypersurfaces of low degree. <i>Geometric Methods in Algebra and Number Theory</i>.  Mathematical Sciences Publishers. <a href=\"https://doi.org/10.2140/ant.2017.11.1657\">https://doi.org/10.2140/ant.2017.11.1657</a>"},"day":"07","publisher":" Mathematical Sciences Publishers","_id":"265","article_type":"original","date_updated":"2024-03-05T11:43:38Z","main_file_link":[{"url":"https://arxiv.org/abs/1611.00553","open_access":"1"}],"oa":1,"language":[{"iso":"eng"}],"abstract":[{"text":"We establish the dimension and irreducibility of the moduli space of rational curves (of fixed degree) on arbitrary smooth hypersurfaces of sufficiently low degree. A spreading out argument reduces the problem to hypersurfaces defined over finite fields of large cardinality, which can then be tackled using a function field version of the Hardy-Littlewood circle method, in which particular care is taken to ensure uniformity in the size of the underlying finite field.","lang":"eng"}],"date_created":"2018-12-11T11:45:30Z","volume":11},{"citation":{"short":"T.D. Browning, R. Heath Brown, Journal of the European Mathematical Society 19 (2017) 357–394.","ama":"Browning TD, Heath Brown R. Forms in many variables and differing degrees. <i>Journal of the European Mathematical Society</i>. 2017;19(2):357-394. doi:<a href=\"https://doi.org/10.4171/JEMS/668\">10.4171/JEMS/668</a>","apa":"Browning, T. D., &#38; Heath Brown, R. (2017). Forms in many variables and differing degrees. <i>Journal of the European Mathematical Society</i>. European Mathematical Society Publishing House. <a href=\"https://doi.org/10.4171/JEMS/668\">https://doi.org/10.4171/JEMS/668</a>","ieee":"T. D. Browning and R. Heath Brown, “Forms in many variables and differing degrees,” <i>Journal of the European Mathematical Society</i>, vol. 19, no. 2. European Mathematical Society Publishing House, pp. 357–394, 2017.","mla":"Browning, Timothy D., and Roger Heath Brown. “Forms in Many Variables and Differing Degrees.” <i>Journal of the European Mathematical Society</i>, vol. 19, no. 2, European Mathematical Society Publishing House, 2017, pp. 357–94, doi:<a href=\"https://doi.org/10.4171/JEMS/668\">10.4171/JEMS/668</a>.","chicago":"Browning, Timothy D, and Roger Heath Brown. “Forms in Many Variables and Differing Degrees.” <i>Journal of the European Mathematical Society</i>. European Mathematical Society Publishing House, 2017. <a href=\"https://doi.org/10.4171/JEMS/668\">https://doi.org/10.4171/JEMS/668</a>.","ista":"Browning TD, Heath Brown R. 2017. Forms in many variables and differing degrees. Journal of the European Mathematical Society. 19(2), 357–394."},"_id":"266","publisher":"European Mathematical Society Publishing House","day":"26","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We generalise Birch's seminal work on forms in many variables to handle a system of forms in which the degrees need not all be the same. This allows us to prove the Hasse principle, weak approximation, and the Manin-Peyre conjecture for a smooth and geometrically integral variety X Pm, provided only that its dimension is large enough in terms of its degree."}],"date_created":"2018-12-11T11:45:31Z","volume":19,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1403.5937"}],"article_type":"original","date_updated":"2024-03-05T11:47:15Z","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"2","type":"journal_article","publist_id":"7636","page":"357 - 394","title":"Forms in many variables and differing degrees","status":"public","intvolume":"        19","month":"01","author":[{"last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","full_name":"Browning, Timothy D","first_name":"Timothy D","orcid":"0000-0002-8314-0177"},{"last_name":"Heath Brown","first_name":"Roger","full_name":"Heath Brown, Roger"}],"extern":"1","quality_controlled":"1","acknowledgement":"While working on this paper the first author was supported by ERC grant 306457.","arxiv":1,"external_id":{"arxiv":["1403.5937"]},"publication":"Journal of the European Mathematical Society","date_published":"2017-01-26T00:00:00Z","article_processing_charge":"No","publication_status":"published","oa_version":"Preprint","doi":"10.4171/JEMS/668","year":"2017"},{"external_id":{"arxiv":["1701.00525"]},"publication":"Mathematika","date_published":"2017-11-29T00:00:00Z","arxiv":1,"acknowledgement":"While working on this paper the author was supported by ERC grant 306457.","quality_controlled":"1","intvolume":"        63","author":[{"last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177","full_name":"Browning, Timothy D","first_name":"Timothy D"}],"month":"11","extern":"1","doi":"10.1112/S0025579317000195","year":"2017","oa_version":"Preprint","article_processing_charge":"No","publication_status":"published","article_type":"original","date_updated":"2024-03-05T11:49:27Z","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1701.00525"}],"oa":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Building on recent work of Bhargava, Elkies and Schnidman and of Kriz and Li, we produce infinitely many smooth cubic surfaces defined over the field of rational numbers that contain rational points."}],"date_created":"2018-12-11T11:45:31Z","volume":63,"citation":{"apa":"Browning, T. D. (2017). Many cubic surfaces contain rational points. <i>Mathematika</i>. Cambridge University Press. <a href=\"https://doi.org/10.1112/S0025579317000195\">https://doi.org/10.1112/S0025579317000195</a>","ama":"Browning TD. Many cubic surfaces contain rational points. <i>Mathematika</i>. 2017;63(3):818-839. doi:<a href=\"https://doi.org/10.1112/S0025579317000195\">10.1112/S0025579317000195</a>","short":"T.D. Browning, Mathematika 63 (2017) 818–839.","ista":"Browning TD. 2017. Many cubic surfaces contain rational points. Mathematika. 63(3), 818–839.","mla":"Browning, Timothy D. “Many Cubic Surfaces Contain Rational Points.” <i>Mathematika</i>, vol. 63, no. 3, Cambridge University Press, 2017, pp. 818–39, doi:<a href=\"https://doi.org/10.1112/S0025579317000195\">10.1112/S0025579317000195</a>.","chicago":"Browning, Timothy D. “Many Cubic Surfaces Contain Rational Points.” <i>Mathematika</i>. Cambridge University Press, 2017. <a href=\"https://doi.org/10.1112/S0025579317000195\">https://doi.org/10.1112/S0025579317000195</a>.","ieee":"T. D. Browning, “Many cubic surfaces contain rational points,” <i>Mathematika</i>, vol. 63, no. 3. Cambridge University Press, pp. 818–839, 2017."},"day":"29","publisher":"Cambridge University Press","_id":"267","type":"journal_article","publist_id":"7635","publication_identifier":{"issn":["0025-5793"]},"title":"Many cubic surfaces contain rational points","status":"public","page":"818 - 839","issue":"3","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"date_published":"2017-04-01T00:00:00Z","publication":"International Mathematics Research Notices","external_id":{"arxiv":["1510.00136"]},"acknowledgement":"Whilst working on this paper the authors were supported by ERC grant 306457.","arxiv":1,"quality_controlled":"1","extern":"1","intvolume":"      2017","author":[{"last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177","first_name":"Timothy D","full_name":"Browning, Timothy D"},{"last_name":"Prendiville","full_name":"Prendiville, Sean","first_name":"Sean"}],"month":"04","year":"2017","doi":"10.1093/imrn/rnw096","oa_version":"Preprint","publication_status":"published","article_processing_charge":"No","oa":1,"date_updated":"2024-03-05T11:52:36Z","article_type":"original","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1510.00136"}],"date_created":"2018-12-11T11:45:31Z","abstract":[{"lang":"eng","text":"We show that any subset of the squares of positive relative upper density contains nontrivial solutions to a translation-invariant linear equation in five or more variables, with explicit quantitative bounds. As a consequence, we establish the partition regularity of any diagonal quadric in five or more variables whose coefficients sum to zero. Unlike previous approaches, which are limited to equations in seven or more variables, we employ transference technology of Green to import bounds from the linear setting."}],"volume":2017,"language":[{"iso":"eng"}],"publisher":"Oxford University Press","_id":"268","day":"01","citation":{"short":"T.D. Browning, S. Prendiville, International Mathematics Research Notices 2017 (2017) 2219–2248.","apa":"Browning, T. D., &#38; Prendiville, S. (2017). A transference approach to a Roth-type theorem in the squares. <i>International Mathematics Research Notices</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/imrn/rnw096\">https://doi.org/10.1093/imrn/rnw096</a>","ama":"Browning TD, Prendiville S. A transference approach to a Roth-type theorem in the squares. <i>International Mathematics Research Notices</i>. 2017;2017(7):2219-2248. doi:<a href=\"https://doi.org/10.1093/imrn/rnw096\">10.1093/imrn/rnw096</a>","ista":"Browning TD, Prendiville S. 2017. A transference approach to a Roth-type theorem in the squares. International Mathematics Research Notices. 2017(7), 2219–2248.","chicago":"Browning, Timothy D, and Sean Prendiville. “A Transference Approach to a Roth-Type Theorem in the Squares.” <i>International Mathematics Research Notices</i>. Oxford University Press, 2017. <a href=\"https://doi.org/10.1093/imrn/rnw096\">https://doi.org/10.1093/imrn/rnw096</a>.","mla":"Browning, Timothy D., and Sean Prendiville. “A Transference Approach to a Roth-Type Theorem in the Squares.” <i>International Mathematics Research Notices</i>, vol. 2017, no. 7, Oxford University Press, 2017, pp. 2219–48, doi:<a href=\"https://doi.org/10.1093/imrn/rnw096\">10.1093/imrn/rnw096</a>.","ieee":"T. D. Browning and S. Prendiville, “A transference approach to a Roth-type theorem in the squares,” <i>International Mathematics Research Notices</i>, vol. 2017, no. 7. Oxford University Press, pp. 2219–2248, 2017."},"page":"2219 - 2248","publication_identifier":{"issn":["1073-7928"]},"title":"A transference approach to a Roth-type theorem in the squares","status":"public","publist_id":"7634","type":"journal_article","issue":"7","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"issue":"3-4","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"7633","type":"journal_article","status":"public","title":"Varieties with too many rational points","page":"1249 - 1267","citation":{"apa":"Browning, T. D., &#38; Loughran, D. (2017). Varieties with too many rational points. <i>Mathematische Zeitschrift</i>. Springer. <a href=\"https://doi.org/10.1007/s00209-016-1746-2\">https://doi.org/10.1007/s00209-016-1746-2</a>","ama":"Browning TD, Loughran D. Varieties with too many rational points. <i>Mathematische Zeitschrift</i>. 2017;285(3-4):1249-1267. doi:<a href=\"https://doi.org/10.1007/s00209-016-1746-2\">10.1007/s00209-016-1746-2</a>","short":"T.D. Browning, D. Loughran, Mathematische Zeitschrift 285 (2017) 1249–1267.","mla":"Browning, Timothy D., and Daniel Loughran. “Varieties with Too Many Rational Points.” <i>Mathematische Zeitschrift</i>, vol. 285, no. 3–4, Springer, 2017, pp. 1249–67, doi:<a href=\"https://doi.org/10.1007/s00209-016-1746-2\">10.1007/s00209-016-1746-2</a>.","chicago":"Browning, Timothy D, and Daniel Loughran. “Varieties with Too Many Rational Points.” <i>Mathematische Zeitschrift</i>. Springer, 2017. <a href=\"https://doi.org/10.1007/s00209-016-1746-2\">https://doi.org/10.1007/s00209-016-1746-2</a>.","ista":"Browning TD, Loughran D. 2017. Varieties with too many rational points. Mathematische Zeitschrift. 285(3–4), 1249–1267.","ieee":"T. D. Browning and D. Loughran, “Varieties with too many rational points,” <i>Mathematische Zeitschrift</i>, vol. 285, no. 3–4. Springer, pp. 1249–1267, 2017."},"day":"01","_id":"269","publisher":"Springer","main_file_link":[{"url":"https://arxiv.org/abs/1311.5755","open_access":"1"}],"article_type":"original","date_updated":"2024-03-05T11:56:29Z","oa":1,"language":[{"iso":"eng"}],"abstract":[{"text":"We investigate Fano varieties defined over a number field that contain subvarieties whose number of rational points of bounded height is comparable to the total number on the variety.","lang":"eng"}],"date_created":"2018-12-11T11:45:32Z","volume":285,"oa_version":"Preprint","article_processing_charge":"No","publication_status":"published","doi":"10.1007/s00209-016-1746-2","year":"2017","quality_controlled":"1","month":"04","author":[{"last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","first_name":"Timothy D","full_name":"Browning, Timothy D","orcid":"0000-0002-8314-0177"},{"first_name":"Daniel","full_name":"Loughran, Daniel","last_name":"Loughran"}],"intvolume":"       285","extern":"1","external_id":{"arxiv":["1311.5755"]},"publication":"Mathematische Zeitschrift","date_published":"2017-04-01T00:00:00Z","arxiv":1},{"quality_controlled":"1","extern":"1","month":"06","intvolume":"       114","author":[{"last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8314-0177","full_name":"Browning, Timothy D","first_name":"Timothy D"},{"first_name":"Alexander","full_name":"Gorodnik, Alexander","last_name":"Gorodnik"}],"date_published":"2017-06-01T00:00:00Z","publication":"Proceedings of the London Mathematical Society","external_id":{"arxiv":["1606.06342"]},"acknowledgement":"While working on this paper the authors were supported by ERC grants 306457 and 239606, respectively.","arxiv":1,"oa_version":"Preprint","publication_status":"published","article_processing_charge":"No","year":"2017","doi":"10.1112/plms.12030","publisher":"Wiley","_id":"270","day":"01","citation":{"mla":"Browning, Timothy D., and Alexander Gorodnik. “Power-Free Values of Polynomials on Symmetric Varieties.” <i>Proceedings of the London Mathematical Society</i>, vol. 114, no. 6, Wiley, 2017, pp. 1044–80, doi:<a href=\"https://doi.org/10.1112/plms.12030\">10.1112/plms.12030</a>.","ista":"Browning TD, Gorodnik A. 2017. Power-free values of polynomials on symmetric varieties. Proceedings of the London Mathematical Society. 114(6), 1044–1080.","chicago":"Browning, Timothy D, and Alexander Gorodnik. “Power-Free Values of Polynomials on Symmetric Varieties.” <i>Proceedings of the London Mathematical Society</i>. Wiley, 2017. <a href=\"https://doi.org/10.1112/plms.12030\">https://doi.org/10.1112/plms.12030</a>.","ieee":"T. D. Browning and A. Gorodnik, “Power-free values of polynomials on symmetric varieties,” <i>Proceedings of the London Mathematical Society</i>, vol. 114, no. 6. Wiley, pp. 1044–1080, 2017.","apa":"Browning, T. D., &#38; Gorodnik, A. (2017). Power-free values of polynomials on symmetric varieties. <i>Proceedings of the London Mathematical Society</i>. Wiley. <a href=\"https://doi.org/10.1112/plms.12030\">https://doi.org/10.1112/plms.12030</a>","ama":"Browning TD, Gorodnik A. Power-free values of polynomials on symmetric varieties. <i>Proceedings of the London Mathematical Society</i>. 2017;114(6):1044-1080. doi:<a href=\"https://doi.org/10.1112/plms.12030\">10.1112/plms.12030</a>","short":"T.D. Browning, A. Gorodnik, Proceedings of the London Mathematical Society 114 (2017) 1044–1080."},"oa":1,"article_type":"original","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1606.06342"}],"date_updated":"2024-03-05T11:58:25Z","volume":114,"date_created":"2018-12-11T11:45:32Z","abstract":[{"text":"Given a symmetric variety Y defined over Q and a non-zero polynomial with integer coefficients, we use techniques from homogeneous dynamics to establish conditions under which the polynomial can be made r-free for a Zariski dense set of integral points on Y . We also establish an asymptotic counting formula for this set. In the special case that Y is a quadric hypersurface, we give explicit bounds on the size of r by combining the argument with a uniform upper bound for the density of integral points on general affine quadrics defined over Q.","lang":"eng"}],"language":[{"iso":"eng"}],"issue":"6","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"1044 - 1080","publication_identifier":{"issn":["0024-6115"]},"title":"Power-free values of polynomials on symmetric varieties","status":"public","type":"journal_article","publist_id":"7632"},{"oa_version":"Submitted Version","publication_status":"published","article_processing_charge":"No","year":"2017","doi":"10.24033/asens.2348","quality_controlled":"1","extern":"1","month":"12","author":[{"first_name":"Timothy D","full_name":"Browning, Timothy D","orcid":"0000-0002-8314-0177","last_name":"Browning","id":"35827D50-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Matthiesen","full_name":"Matthiesen, Lilian","first_name":"Lilian"}],"intvolume":"        50","date_published":"2017-12-01T00:00:00Z","publication":"Annales Scientifiques de l'Ecole Normale Superieure","acknowledgement":"While working on this paper the first author was supported by ERC grant 306457 and the second author was supported by EPSRC grant EP/E053262/1 and by ERC grant 208091. Some of this work was carried out during the programme “Arithmetic and geometry” in 2013 at the Hausdorff Institute in Bonn.","issue":"6","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","title":"Norm forms for arbitrary number fields as products of linear polynomials","page":"1383 - 1446","type":"journal_article","publist_id":"7630","day":"01","_id":"272","publisher":"Societe Mathematique de France","citation":{"ieee":"T. D. Browning and L. Matthiesen, “Norm forms for arbitrary number fields as products of linear polynomials,” <i>Annales Scientifiques de l’Ecole Normale Superieure</i>, vol. 50, no. 6. Societe Mathematique de France, pp. 1383–1446, 2017.","chicago":"Browning, Timothy D, and Lilian Matthiesen. “Norm Forms for Arbitrary Number Fields as Products of Linear Polynomials.” <i>Annales Scientifiques de l’Ecole Normale Superieure</i>. Societe Mathematique de France, 2017. <a href=\"https://doi.org/10.24033/asens.2348\">https://doi.org/10.24033/asens.2348</a>.","ista":"Browning TD, Matthiesen L. 2017. Norm forms for arbitrary number fields as products of linear polynomials. Annales Scientifiques de l’Ecole Normale Superieure. 50(6), 1383–1446.","mla":"Browning, Timothy D., and Lilian Matthiesen. “Norm Forms for Arbitrary Number Fields as Products of Linear Polynomials.” <i>Annales Scientifiques de l’Ecole Normale Superieure</i>, vol. 50, no. 6, Societe Mathematique de France, 2017, pp. 1383–446, doi:<a href=\"https://doi.org/10.24033/asens.2348\">10.24033/asens.2348</a>.","short":"T.D. Browning, L. Matthiesen, Annales Scientifiques de l’Ecole Normale Superieure 50 (2017) 1383–1446.","ama":"Browning TD, Matthiesen L. Norm forms for arbitrary number fields as products of linear polynomials. <i>Annales Scientifiques de l’Ecole Normale Superieure</i>. 2017;50(6):1383-1446. doi:<a href=\"https://doi.org/10.24033/asens.2348\">10.24033/asens.2348</a>","apa":"Browning, T. D., &#38; Matthiesen, L. (2017). Norm forms for arbitrary number fields as products of linear polynomials. <i>Annales Scientifiques de l’Ecole Normale Superieure</i>. Societe Mathematique de France. <a href=\"https://doi.org/10.24033/asens.2348\">https://doi.org/10.24033/asens.2348</a>"},"oa":1,"article_type":"original","main_file_link":[{"open_access":"1","url":"https://research-information.bristol.ac.uk/en/publications/norm-forms-for-arbitrary-number-fields-as-products-of-linear-polynomials(f79a584b-ec58-47c8-aa97-8c5505e3f751).html"}],"date_updated":"2024-03-05T12:13:35Z","abstract":[{"lang":"eng","text":"Given a number field K/Q and a polynomial P ε Q [t], all of whose roots are Q, let X be the variety defined by the equation NK (x) = P (t). Combining additive combinatiorics with descent we show that the Brauer-Manin obstruction is the only obstruction to the Hesse principle and weak approximation on any smooth and projective model of X."}],"date_created":"2018-12-11T11:45:32Z","volume":50,"language":[{"iso":"eng"}]},{"department":[{"_id":"VlKo"}],"publisher":"ML Research Press","_id":"274","day":"27","citation":{"apa":"Kolmogorov, V. (2017). A faster approximation algorithm for the Gibbs partition function. In <i>Proceedings of the 31st Conference On Learning Theory</i> (Vol. 75, pp. 228–249). ML Research Press.","ama":"Kolmogorov V. A faster approximation algorithm for the Gibbs partition function. In: <i>Proceedings of the 31st Conference On Learning Theory</i>. Vol 75. ML Research Press; 2017:228-249.","short":"V. Kolmogorov, in:, Proceedings of the 31st Conference On Learning Theory, ML Research Press, 2017, pp. 228–249.","ista":"Kolmogorov V. 2017. A faster approximation algorithm for the Gibbs partition function. Proceedings of the 31st Conference On Learning Theory. COLT: Annual Conference on Learning Theory  vol. 75, 228–249.","chicago":"Kolmogorov, Vladimir. “A Faster Approximation Algorithm for the Gibbs Partition Function.” In <i>Proceedings of the 31st Conference On Learning Theory</i>, 75:228–49. ML Research Press, 2017.","mla":"Kolmogorov, Vladimir. “A Faster Approximation Algorithm for the Gibbs Partition Function.” <i>Proceedings of the 31st Conference On Learning Theory</i>, vol. 75, ML Research Press, 2017, pp. 228–49.","ieee":"V. Kolmogorov, “A faster approximation algorithm for the Gibbs partition function,” in <i>Proceedings of the 31st Conference On Learning Theory</i>, 2017, vol. 75, pp. 228–249."},"oa":1,"date_updated":"2023-10-17T12:32:13Z","date_created":"2018-12-11T11:45:33Z","abstract":[{"lang":"eng","text":"We consider the problem of estimating the partition function Z(β)=∑xexp(−β(H(x)) of a Gibbs distribution with a Hamilton H(⋅), or more precisely the logarithm of the ratio q=lnZ(0)/Z(β). It has been recently shown how to approximate q with high probability assuming the existence of an oracle that produces samples from the Gibbs distribution for a given parameter value in [0,β]. The current best known approach due to Huber [9] uses O(qlnn⋅[lnq+lnlnn+ε−2]) oracle calls on average where ε is the desired accuracy of approximation and H(⋅) is assumed to lie in {0}∪[1,n]. We improve the complexity to O(qlnn⋅ε−2) oracle calls. We also show that the same complexity can be achieved if exact oracles are replaced with approximate sampling oracles that are within O(ε2qlnn) variation distance from exact oracles. Finally, we prove a lower bound of Ω(q⋅ε−2) oracle calls under a natural model of computation."}],"volume":75,"language":[{"iso":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file_date_updated":"2020-07-14T12:45:45Z","ec_funded":1,"page":"228-249","status":"public","title":"A faster approximation algorithm for the Gibbs partition function","publist_id":"7628","type":"conference","quality_controlled":"1","author":[{"id":"3D50B0BA-F248-11E8-B48F-1D18A9856A87","last_name":"Kolmogorov","full_name":"Kolmogorov, Vladimir","first_name":"Vladimir"}],"intvolume":"        75","month":"12","date_published":"2017-12-27T00:00:00Z","conference":{"name":"COLT: Annual Conference on Learning Theory ","end_date":"2018-07-09","start_date":"2018-07-06"},"publication":"Proceedings of the 31st Conference On Learning Theory","external_id":{"arxiv":["1608.04223"]},"arxiv":1,"oa_version":"Published Version","project":[{"_id":"25FBA906-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"616160","name":"Discrete Optimization in Computer Vision: Theory and Practice"}],"publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_processing_charge":"No","year":"2017","has_accepted_license":"1","file":[{"creator":"dernst","file_name":"2018_PMLR_Kolmogorov.pdf","date_created":"2020-05-12T09:23:27Z","access_level":"open_access","relation":"main_file","date_updated":"2020-07-14T12:45:45Z","file_id":"7820","content_type":"application/pdf","checksum":"89db06a0e8083524449cb59b56bf4e5b","file_size":408974}],"ddc":["510"]},{"issue":"1","file_date_updated":"2020-07-14T12:46:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"7552","type":"conference","publication_identifier":{"issn":["17426588"]},"title":"Experimental evidence for Wigner's tunneling time","status":"public","scopus_import":1,"alternative_title":["Journal of Physics: Conference Series"],"department":[{"_id":"MiLe"}],"citation":{"apa":"Camus, N., Yakaboylu, E., Fechner, L., Klaiber, M., Laux, M., Mi, Y., … Moshammer, R. (2017). Experimental evidence for Wigner’s tunneling time (Vol. 999). Presented at the Annual International Laser Physics Workshop LPHYS, Kazan, Russian Federation: American Physical Society. <a href=\"https://doi.org/10.1088/1742-6596/999/1/012004\">https://doi.org/10.1088/1742-6596/999/1/012004</a>","ama":"Camus N, Yakaboylu E, Fechner L, et al. Experimental evidence for Wigner’s tunneling time. In: Vol 999. American Physical Society; 2017. doi:<a href=\"https://doi.org/10.1088/1742-6596/999/1/012004\">10.1088/1742-6596/999/1/012004</a>","short":"N. Camus, E. Yakaboylu, L. Fechner, M. Klaiber, M. Laux, Y. Mi, K. Hatsagortsyan, T. Pfeifer, C. Keitel, R. Moshammer, in:, American Physical Society, 2017.","chicago":"Camus, Nicolas, Enderalp Yakaboylu, Lutz Fechner, Michael Klaiber, Martin Laux, Yonghao Mi, Karen Hatsagortsyan, Thomas Pfeifer, Cristoph Keitel, and Robert Moshammer. “Experimental Evidence for Wigner’s Tunneling Time,” Vol. 999. American Physical Society, 2017. <a href=\"https://doi.org/10.1088/1742-6596/999/1/012004\">https://doi.org/10.1088/1742-6596/999/1/012004</a>.","mla":"Camus, Nicolas, et al. <i>Experimental Evidence for Wigner’s Tunneling Time</i>. Vol. 999, no. 1, 012004, American Physical Society, 2017, doi:<a href=\"https://doi.org/10.1088/1742-6596/999/1/012004\">10.1088/1742-6596/999/1/012004</a>.","ista":"Camus N, Yakaboylu E, Fechner L, Klaiber M, Laux M, Mi Y, Hatsagortsyan K, Pfeifer T, Keitel C, Moshammer R. 2017. Experimental evidence for Wigner’s tunneling time. Annual International Laser Physics Workshop LPHYS, Journal of Physics: Conference Series, vol. 999, 012004.","ieee":"N. Camus <i>et al.</i>, “Experimental evidence for Wigner’s tunneling time,” presented at the Annual International Laser Physics Workshop LPHYS, Kazan, Russian Federation, 2017, vol. 999, no. 1."},"day":"14","_id":"313","publisher":"American Physical Society","date_updated":"2023-02-23T12:36:07Z","oa":1,"language":[{"iso":"eng"}],"abstract":[{"text":"Tunneling of a particle through a potential barrier remains one of the most remarkable quantum phenomena. Owing to advances in laser technology, electric fields comparable to those electrons experience in atoms are readily generated and open opportunities to dynamically investigate the process of electron tunneling through the potential barrier formed by the superposition of both laser and atomic fields. Attosecond-time and angstrom-space resolution of the strong laser-field technique allow to address fundamental questions related to tunneling, which are still open and debated: Which time is spent under the barrier and what momentum is picked up by the particle in the meantime? In this combined experimental and theoretical study we demonstrate that for strong-field ionization the leading quantum mechanical Wigner treatment for the time resolved description of tunneling is valid. We achieve a high sensitivity on the tunneling barrier and unambiguously isolate its effects by performing a differential study of two systems with almost identical tunneling geometry. Moreover, working with a low frequency laser, we essentially limit the non-adiabaticity of the process as a major source of uncertainty. The agreement between experiment and theory implies two substantial corrections with respect to the widely employed quasiclassical treatment: In addition to a non-vanishing longitudinal momentum along the laser field-direction we provide clear evidence for a non-zero tunneling time delay. This addresses also the fundamental question how the transition occurs from the tunnel barrier to free space classical evolution of the ejected electron.","lang":"eng"}],"volume":999,"date_created":"2018-12-11T11:45:46Z","oa_version":"Published Version","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_status":"published","file":[{"file_name":"2017_Physics_Camus.pdf","date_created":"2019-01-22T08:34:10Z","creator":"dernst","access_level":"open_access","relation":"main_file","date_updated":"2020-07-14T12:46:00Z","content_type":"application/pdf","file_id":"5871","file_size":949321,"checksum":"6e70b525a84f6d5fb175c48e9f5cb59a"}],"has_accepted_license":"1","doi":"10.1088/1742-6596/999/1/012004","year":"2017","related_material":{"record":[{"id":"6013","relation":"later_version","status":"public"}]},"ddc":["530"],"quality_controlled":"1","article_number":"012004","author":[{"first_name":"Nicolas","full_name":"Camus, Nicolas","last_name":"Camus"},{"last_name":"Yakaboylu","id":"38CB71F6-F248-11E8-B48F-1D18A9856A87","first_name":"Enderalp","orcid":"0000-0001-5973-0874","full_name":"Yakaboylu, Enderalp"},{"first_name":"Lutz","full_name":"Fechner, Lutz","last_name":"Fechner"},{"first_name":"Michael","full_name":"Klaiber, Michael","last_name":"Klaiber"},{"full_name":"Laux, Martin","first_name":"Martin","last_name":"Laux"},{"last_name":"Mi","full_name":"Mi, Yonghao","first_name":"Yonghao"},{"first_name":"Karen","full_name":"Hatsagortsyan, Karen","last_name":"Hatsagortsyan"},{"full_name":"Pfeifer, Thomas","first_name":"Thomas","last_name":"Pfeifer"},{"last_name":"Keitel","first_name":"Cristoph","full_name":"Keitel, Cristoph"},{"last_name":"Moshammer","full_name":"Moshammer, Robert","first_name":"Robert"}],"intvolume":"       999","month":"07","external_id":{"arxiv":["1611.03701"]},"conference":{"end_date":"2017-08-21","start_date":"2017-08-17","location":"Kazan, Russian Federation","name":"Annual International Laser Physics Workshop LPHYS"},"date_published":"2017-07-14T00:00:00Z","arxiv":1},{"quality_controlled":"1","article_number":"14251","author":[{"full_name":"Wright, Alison","first_name":"Alison","last_name":"Wright"},{"last_name":"Darolti","first_name":"Iulia","full_name":"Darolti, Iulia"},{"first_name":"Natasha","full_name":"Bloch, Natasha","last_name":"Bloch"},{"full_name":"Oostra, Vicencio","first_name":"Vicencio","last_name":"Oostra"},{"first_name":"Benjamin","full_name":"Sandkam, Benjamin","last_name":"Sandkam"},{"full_name":"Buechel, Séverine","first_name":"Séverine","last_name":"Buechel"},{"full_name":"Kolm, Niclas","first_name":"Niclas","last_name":"Kolm"},{"last_name":"Breden","full_name":"Breden, Felix","first_name":"Felix"},{"orcid":"0000-0002-4579-8306","full_name":"Vicoso, Beatriz","first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso"},{"full_name":"Mank, Judith","first_name":"Judith","last_name":"Mank"}],"intvolume":"         8","month":"01","external_id":{"isi":["000392953700001"]},"publication":"Nature Communications","date_published":"2017-01-31T00:00:00Z","oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"doi":"10.1038/ncomms14251","has_accepted_license":"1","file":[{"file_size":955256,"access_level":"open_access","date_created":"2018-12-12T10:15:22Z","file_name":"IST-2017-791-v1+1_ncomms14251.pdf","creator":"system","content_type":"application/pdf","file_id":"5141","date_updated":"2018-12-12T10:15:22Z","relation":"main_file"}],"year":"2017","ddc":["570","576"],"department":[{"_id":"BeVi"}],"citation":{"ista":"Wright A, Darolti I, Bloch N, Oostra V, Sandkam B, Buechel S, Kolm N, Breden F, Vicoso B, Mank J. 2017. Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. Nature Communications. 8, 14251.","mla":"Wright, Alison, et al. “Convergent Recombination Suppression Suggests Role of Sexual Selection in Guppy Sex Chromosome Formation.” <i>Nature Communications</i>, vol. 8, 14251, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/ncomms14251\">10.1038/ncomms14251</a>.","chicago":"Wright, Alison, Iulia Darolti, Natasha Bloch, Vicencio Oostra, Benjamin Sandkam, Séverine Buechel, Niclas Kolm, Felix Breden, Beatriz Vicoso, and Judith Mank. “Convergent Recombination Suppression Suggests Role of Sexual Selection in Guppy Sex Chromosome Formation.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/ncomms14251\">https://doi.org/10.1038/ncomms14251</a>.","ieee":"A. Wright <i>et al.</i>, “Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation,” <i>Nature Communications</i>, vol. 8. Nature Publishing Group, 2017.","short":"A. Wright, I. Darolti, N. Bloch, V. Oostra, B. Sandkam, S. Buechel, N. Kolm, F. Breden, B. Vicoso, J. Mank, Nature Communications 8 (2017).","apa":"Wright, A., Darolti, I., Bloch, N., Oostra, V., Sandkam, B., Buechel, S., … Mank, J. (2017). Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/ncomms14251\">https://doi.org/10.1038/ncomms14251</a>","ama":"Wright A, Darolti I, Bloch N, et al. Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation. <i>Nature Communications</i>. 2017;8. doi:<a href=\"https://doi.org/10.1038/ncomms14251\">10.1038/ncomms14251</a>"},"pubrep_id":"791","_id":"1085","publisher":"Nature Publishing Group","day":"31","date_updated":"2023-09-20T11:48:16Z","oa":1,"isi":1,"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Sex chromosomes evolve once recombination is halted between a homologous pair of chromosomes. The dominant model of sex chromosome evolution posits that recombination is suppressed between emerging X and Y chromosomes in order to resolve sexual conflict. Here we test this model using whole genome and transcriptome resequencing data in the guppy, a model for sexual selection with many Y-linked colour traits. We show that although the nascent Y chromosome encompasses nearly half of the linkage group, there has been no perceptible degradation of Y chromosome gene content or activity. Using replicate wild populations with differing levels of sexually antagonistic selection for colour, we also show that sexual selection leads to greater expansion of the non-recombining region and increased Y chromosome divergence. These results provide empirical support for longstanding models of sex chromosome catalysis, and suggest an important role for sexual selection and sexual conflict in genome evolution."}],"volume":8,"date_created":"2018-12-11T11:50:04Z","file_date_updated":"2018-12-12T10:15:22Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","type":"journal_article","publist_id":"6292","status":"public","publication_identifier":{"issn":["20411723"]},"title":"Convergent recombination suppression suggests role of sexual selection in guppy sex chromosome formation","scopus_import":"1"},{"external_id":{"isi":["000393163800001"]},"publication":"Scientific Reports","date_published":"2017-02-01T00:00:00Z","quality_controlled":"1","month":"02","author":[{"full_name":"Di Giglio, Maria","first_name":"Maria","last_name":"Di Giglio"},{"full_name":"Muttenthaler, Markus","first_name":"Markus","last_name":"Muttenthaler"},{"full_name":"Harpsøe, Kasper","first_name":"Kasper","last_name":"Harpsøe"},{"first_name":"Zita","full_name":"Liutkeviciute, Zita","last_name":"Liutkeviciute"},{"first_name":"Peter","full_name":"Keov, Peter","last_name":"Keov"},{"full_name":"Eder, Thomas","first_name":"Thomas","last_name":"Eder"},{"full_name":"Rattei, Thomas","first_name":"Thomas","last_name":"Rattei"},{"first_name":"Sarah","full_name":"Arrowsmith, Sarah","last_name":"Arrowsmith"},{"full_name":"Wray, Susan","first_name":"Susan","last_name":"Wray"},{"last_name":"Marek","first_name":"Ales","full_name":"Marek, Ales"},{"last_name":"Elbert","full_name":"Elbert, Tomas","first_name":"Tomas"},{"first_name":"Paul","full_name":"Alewood, Paul","last_name":"Alewood"},{"last_name":"Gloriam","full_name":"Gloriam, David","first_name":"David"},{"last_name":"Gruber","first_name":"Christian","full_name":"Gruber, Christian"}],"intvolume":"         7","file":[{"file_size":1994139,"access_level":"open_access","creator":"system","date_created":"2018-12-12T10:14:59Z","file_name":"IST-2017-790-v1+1_srep41002_1_.pdf","content_type":"application/pdf","file_id":"5115","date_updated":"2018-12-12T10:14:59Z","relation":"main_file"}],"has_accepted_license":"1","doi":"10.1038/srep41002","year":"2017","ddc":["570","590"],"oa_version":"Published Version","article_processing_charge":"No","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"publication_status":"published","date_updated":"2023-09-20T11:47:47Z","isi":1,"oa":1,"language":[{"iso":"eng"}],"volume":7,"abstract":[{"lang":"eng","text":"Characterisation of G protein-coupled receptors (GPCR) relies on the availability of a toolbox of ligands that selectively modulate different functional states of the receptors. To uncover such molecules, we explored a unique strategy for ligand discovery that takes advantage of the evolutionary conservation of the 600-million-year-old oxytocin/vasopressin signalling system. We isolated the insect oxytocin/vasopressin orthologue inotocin from the black garden ant (Lasius niger), identified and cloned its cognate receptor and determined its pharmacological properties on the insect and human oxytocin/vasopressin receptors. Subsequently, we identified a functional dichotomy: inotocin activated the insect inotocin and the human vasopressin V1b receptors, but inhibited the human V1aR. Replacement of Arg8 of inotocin by D-Arg8 led to a potent, stable and competitive V1aR-antagonist ([D-Arg8]-inotocin) with a 3,000-fold binding selectivity for the human V1aR over the other three subtypes, OTR, V1bR and V2R. The Arg8/D-Arg8 ligand-pair was further investigated to gain novel insights into the oxytocin/vasopressin peptide-receptor interaction, which led to the identification of key residues of the receptors that are important for ligand functionality and selectivity. These observations could play an important role for development of oxytocin/vasopressin receptor modulators that would enable clear distinction of the physiological and pathological responses of the individual receptor subtypes."}],"date_created":"2018-12-11T11:50:04Z","citation":{"ieee":"M. Di Giglio <i>et al.</i>, “Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide,” <i>Scientific Reports</i>, vol. 7. Nature Publishing Group, p. 41002, 2017.","chicago":"Di Giglio, Maria, Markus Muttenthaler, Kasper Harpsøe, Zita Liutkeviciute, Peter Keov, Thomas Eder, Thomas Rattei, et al. “Development of a Human Vasopressin V1a-Receptor Antagonist from an Evolutionary-Related Insect Neuropeptide.” <i>Scientific Reports</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/srep41002\">https://doi.org/10.1038/srep41002</a>.","mla":"Di Giglio, Maria, et al. “Development of a Human Vasopressin V1a-Receptor Antagonist from an Evolutionary-Related Insect Neuropeptide.” <i>Scientific Reports</i>, vol. 7, Nature Publishing Group, 2017, p. 41002, doi:<a href=\"https://doi.org/10.1038/srep41002\">10.1038/srep41002</a>.","ista":"Di Giglio M, Muttenthaler M, Harpsøe K, Liutkeviciute Z, Keov P, Eder T, Rattei T, Arrowsmith S, Wray S, Marek A, Elbert T, Alewood P, Gloriam D, Gruber C. 2017. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. Scientific Reports. 7, 41002.","short":"M. Di Giglio, M. Muttenthaler, K. Harpsøe, Z. Liutkeviciute, P. Keov, T. Eder, T. Rattei, S. Arrowsmith, S. Wray, A. Marek, T. Elbert, P. Alewood, D. Gloriam, C. Gruber, Scientific Reports 7 (2017) 41002.","ama":"Di Giglio M, Muttenthaler M, Harpsøe K, et al. Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. <i>Scientific Reports</i>. 2017;7:41002. doi:<a href=\"https://doi.org/10.1038/srep41002\">10.1038/srep41002</a>","apa":"Di Giglio, M., Muttenthaler, M., Harpsøe, K., Liutkeviciute, Z., Keov, P., Eder, T., … Gruber, C. (2017). Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide. <i>Scientific Reports</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/srep41002\">https://doi.org/10.1038/srep41002</a>"},"day":"01","publisher":"Nature Publishing Group","_id":"1086","pubrep_id":"790","type":"journal_article","publist_id":"6291","status":"public","scopus_import":"1","title":"Development of a human vasopressin V1a-receptor antagonist from an evolutionary-related insect neuropeptide","page":"41002","file_date_updated":"2018-12-12T10:14:59Z","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"year":"2017","doi":"10.1017/jfm.2017.14","publication_status":"published","article_processing_charge":"No","project":[{"grant_number":"306589","name":"Decoding the complexity of turbulence at its origin","_id":"25152F3A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"oa_version":"Submitted Version","date_published":"2017-02-25T00:00:00Z","publication":"Journal of Fluid Mechanics","external_id":{"isi":["000394376400044"]},"author":[{"full_name":"Song, Baofang","first_name":"Baofang","last_name":"Song"},{"full_name":"Barkley, Dwight","first_name":"Dwight","last_name":"Barkley"},{"last_name":"Hof","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","first_name":"Björn","orcid":"0000-0003-2057-2754"},{"last_name":"Avila","first_name":"Marc","full_name":"Avila, Marc"}],"month":"02","intvolume":"       813","quality_controlled":"1","status":"public","scopus_import":"1","publication_identifier":{"issn":["00221120"]},"title":"Speed and structure of turbulent fronts in pipe flow","page":"1045 - 1059","type":"journal_article","publist_id":"6290","acknowledged_ssus":[{"_id":"ScienComp"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ec_funded":1,"abstract":[{"text":"Using extensive direct numerical simulations, the dynamics of laminar-turbulent fronts in pipe flow is investigated for Reynolds numbers between and 5500. We here investigate the physical distinction between the fronts of weak and strong slugs both by analysing the turbulent kinetic energy budget and by comparing the downstream front motion to the advection speed of bulk turbulent structures. Our study shows that weak downstream fronts travel slower than turbulent structures in the bulk and correspond to decaying turbulence at the front. At the downstream front speed becomes faster than the advection speed, marking the onset of strong fronts. In contrast to weak fronts, turbulent eddies are generated at strong fronts by feeding on the downstream laminar flow. Our study also suggests that temporal fluctuations of production and dissipation at the downstream laminar-turbulent front drive the dynamical switches between the two types of front observed up to.","lang":"eng"}],"date_created":"2018-12-11T11:50:04Z","volume":813,"language":[{"iso":"eng"}],"isi":1,"oa":1,"date_updated":"2023-09-20T11:47:22Z","main_file_link":[{"url":"https://arxiv.org/abs/1603.04077","open_access":"1"}],"day":"25","publisher":"Cambridge University Press","_id":"1087","citation":{"apa":"Song, B., Barkley, D., Hof, B., &#38; Avila, M. (2017). Speed and structure of turbulent fronts in pipe flow. <i>Journal of Fluid Mechanics</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/jfm.2017.14\">https://doi.org/10.1017/jfm.2017.14</a>","ama":"Song B, Barkley D, Hof B, Avila M. Speed and structure of turbulent fronts in pipe flow. <i>Journal of Fluid Mechanics</i>. 2017;813:1045-1059. doi:<a href=\"https://doi.org/10.1017/jfm.2017.14\">10.1017/jfm.2017.14</a>","short":"B. Song, D. Barkley, B. Hof, M. Avila, Journal of Fluid Mechanics 813 (2017) 1045–1059.","mla":"Song, Baofang, et al. “Speed and Structure of Turbulent Fronts in Pipe Flow.” <i>Journal of Fluid Mechanics</i>, vol. 813, Cambridge University Press, 2017, pp. 1045–59, doi:<a href=\"https://doi.org/10.1017/jfm.2017.14\">10.1017/jfm.2017.14</a>.","chicago":"Song, Baofang, Dwight Barkley, Björn Hof, and Marc Avila. “Speed and Structure of Turbulent Fronts in Pipe Flow.” <i>Journal of Fluid Mechanics</i>. Cambridge University Press, 2017. <a href=\"https://doi.org/10.1017/jfm.2017.14\">https://doi.org/10.1017/jfm.2017.14</a>.","ista":"Song B, Barkley D, Hof B, Avila M. 2017. Speed and structure of turbulent fronts in pipe flow. Journal of Fluid Mechanics. 813, 1045–1059.","ieee":"B. Song, D. Barkley, B. Hof, and M. Avila, “Speed and structure of turbulent fronts in pipe flow,” <i>Journal of Fluid Mechanics</i>, vol. 813. Cambridge University Press, pp. 1045–1059, 2017."},"department":[{"_id":"BjHo"}]},{"department":[{"_id":"CaUh"}],"day":"01","publisher":"Institute of Mathematical Statistics","_id":"1089","citation":{"apa":"Fallat, S., Lauritzen, S., Sadeghi, K., Uhler, C., Wermuth, N., &#38; Zwiernik, P. (2017). Total positivity in Markov structures. <i>Annals of Statistics</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/16-AOS1478\">https://doi.org/10.1214/16-AOS1478</a>","ama":"Fallat S, Lauritzen S, Sadeghi K, Uhler C, Wermuth N, Zwiernik P. Total positivity in Markov structures. <i>Annals of Statistics</i>. 2017;45(3):1152-1184. doi:<a href=\"https://doi.org/10.1214/16-AOS1478\">10.1214/16-AOS1478</a>","short":"S. Fallat, S. Lauritzen, K. Sadeghi, C. Uhler, N. Wermuth, P. Zwiernik, Annals of Statistics 45 (2017) 1152–1184.","ista":"Fallat S, Lauritzen S, Sadeghi K, Uhler C, Wermuth N, Zwiernik P. 2017. Total positivity in Markov structures. Annals of Statistics. 45(3), 1152–1184.","mla":"Fallat, Shaun, et al. “Total Positivity in Markov Structures.” <i>Annals of Statistics</i>, vol. 45, no. 3, Institute of Mathematical Statistics, 2017, pp. 1152–84, doi:<a href=\"https://doi.org/10.1214/16-AOS1478\">10.1214/16-AOS1478</a>.","chicago":"Fallat, Shaun, Steffen Lauritzen, Kayvan Sadeghi, Caroline Uhler, Nanny Wermuth, and Piotr Zwiernik. “Total Positivity in Markov Structures.” <i>Annals of Statistics</i>. Institute of Mathematical Statistics, 2017. <a href=\"https://doi.org/10.1214/16-AOS1478\">https://doi.org/10.1214/16-AOS1478</a>.","ieee":"S. Fallat, S. Lauritzen, K. Sadeghi, C. Uhler, N. Wermuth, and P. Zwiernik, “Total positivity in Markov structures,” <i>Annals of Statistics</i>, vol. 45, no. 3. Institute of Mathematical Statistics, pp. 1152–1184, 2017."},"isi":1,"oa":1,"main_file_link":[{"url":"https://arxiv.org/abs/1510.01290","open_access":"1"}],"date_updated":"2023-09-20T11:46:53Z","volume":45,"date_created":"2018-12-11T11:50:05Z","abstract":[{"lang":"eng","text":"We discuss properties of distributions that are multivariate totally positive of order two (MTP2) related to conditional independence. In particular, we show that any independence model generated by an MTP2 distribution is a compositional semigraphoid which is upward-stable and singleton-transitive. In addition, we prove that any MTP2 distribution satisfying an appropriate support condition is faithful to its concentration graph. Finally, we analyze factorization properties of MTP2 distributions and discuss ways of constructing MTP2 distributions; in particular we give conditions on the log-linear parameters of a discrete distribution which ensure MTP2 and characterize conditional Gaussian distributions which satisfy MTP2."}],"language":[{"iso":"eng"}],"issue":"3","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","scopus_import":"1","status":"public","title":"Total positivity in Markov structures","publication_identifier":{"issn":["00905364"]},"page":"1152 - 1184","type":"journal_article","publist_id":"6288","quality_controlled":"1","month":"06","intvolume":"        45","author":[{"last_name":"Fallat","full_name":"Fallat, Shaun","first_name":"Shaun"},{"first_name":"Steffen","full_name":"Lauritzen, Steffen","last_name":"Lauritzen"},{"first_name":"Kayvan","full_name":"Sadeghi, Kayvan","last_name":"Sadeghi"},{"first_name":"Caroline","orcid":"0000-0002-7008-0216","full_name":"Uhler, Caroline","last_name":"Uhler","id":"49ADD78E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Nanny","full_name":"Wermuth, Nanny","last_name":"Wermuth"},{"last_name":"Zwiernik","first_name":"Piotr","full_name":"Zwiernik, Piotr"}],"date_published":"2017-06-01T00:00:00Z","publication":"Annals of Statistics","external_id":{"isi":["000404395900008"]},"project":[{"grant_number":"Y 903-N35","name":"Gaussian Graphical Models: Theory and Applications","_id":"2530CA10-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"oa_version":"Submitted Version","publication_status":"published","article_processing_charge":"No","year":"2017","doi":"10.1214/16-AOS1478"},{"oa":1,"isi":1,"date_updated":"2023-09-20T11:41:19Z","abstract":[{"text":"In the early visual system, cells of the same type perform the same computation in different places of the visual field. How these cells code together a complex visual scene is unclear. A common assumption is that cells of a single-type extract a single-stimulus feature to form a feature map, but this has rarely been observed directly. Using large-scale recordings in the rat retina, we show that a homogeneous population of fast OFF ganglion cells simultaneously encodes two radically different features of a visual scene. Cells close to a moving object code quasilinearly for its position, while distant cells remain largely invariant to the object's position and, instead, respond nonlinearly to changes in the object's speed. We develop a quantitative model that accounts for this effect and identify a disinhibitory circuit that mediates it. Ganglion cells of a single type thus do not code for one, but two features simultaneously. This richer, flexible neural map might also be present in other sensory systems.","lang":"eng"}],"volume":8,"date_created":"2018-12-11T11:50:10Z","language":[{"iso":"eng"}],"department":[{"_id":"GaTk"}],"_id":"1104","pubrep_id":"921","publisher":"Nature Publishing Group","day":"06","citation":{"apa":"Deny, S., Ferrari, U., Mace, E., Yger, P., Caplette, R., Picaud, S., … Marre, O. (2017). Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41467-017-02159-y\">https://doi.org/10.1038/s41467-017-02159-y</a>","ama":"Deny S, Ferrari U, Mace E, et al. Multiplexed computations in retinal ganglion cells of a single type. <i>Nature Communications</i>. 2017;8(1). doi:<a href=\"https://doi.org/10.1038/s41467-017-02159-y\">10.1038/s41467-017-02159-y</a>","short":"S. Deny, U. Ferrari, E. Mace, P. Yger, R. Caplette, S. Picaud, G. Tkačik, O. Marre, Nature Communications 8 (2017).","chicago":"Deny, Stephane, Ulisse Ferrari, Emilie Mace, Pierre Yger, Romain Caplette, Serge Picaud, Gašper Tkačik, and Olivier Marre. “Multiplexed Computations in Retinal Ganglion Cells of a Single Type.” <i>Nature Communications</i>. Nature Publishing Group, 2017. <a href=\"https://doi.org/10.1038/s41467-017-02159-y\">https://doi.org/10.1038/s41467-017-02159-y</a>.","mla":"Deny, Stephane, et al. “Multiplexed Computations in Retinal Ganglion Cells of a Single Type.” <i>Nature Communications</i>, vol. 8, no. 1, 1964, Nature Publishing Group, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-02159-y\">10.1038/s41467-017-02159-y</a>.","ista":"Deny S, Ferrari U, Mace E, Yger P, Caplette R, Picaud S, Tkačik G, Marre O. 2017. Multiplexed computations in retinal ganglion cells of a single type. Nature Communications. 8(1), 1964.","ieee":"S. Deny <i>et al.</i>, “Multiplexed computations in retinal ganglion cells of a single type,” <i>Nature Communications</i>, vol. 8, no. 1. Nature Publishing Group, 2017."},"scopus_import":"1","publication_identifier":{"issn":["20411723"]},"status":"public","title":"Multiplexed computations in retinal ganglion cells of a single type","type":"journal_article","publist_id":"6266","issue":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ec_funded":1,"file_date_updated":"2018-12-12T10:16:06Z","date_published":"2017-12-06T00:00:00Z","publication":"Nature Communications","external_id":{"isi":["000417241200004"]},"article_number":"1964","quality_controlled":"1","month":"12","intvolume":"         8","author":[{"first_name":"Stephane","full_name":"Deny, Stephane","last_name":"Deny"},{"last_name":"Ferrari","full_name":"Ferrari, Ulisse","first_name":"Ulisse"},{"first_name":"Emilie","full_name":"Mace, Emilie","last_name":"Mace"},{"full_name":"Yger, Pierre","first_name":"Pierre","last_name":"Yger"},{"last_name":"Caplette","full_name":"Caplette, Romain","first_name":"Romain"},{"last_name":"Picaud","full_name":"Picaud, Serge","first_name":"Serge"},{"full_name":"Tkacik, Gasper","orcid":"0000-0002-6699-1455","first_name":"Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","last_name":"Tkacik"},{"first_name":"Olivier","full_name":"Marre, Olivier","last_name":"Marre"}],"year":"2017","doi":"10.1038/s41467-017-02159-y","file":[{"file_name":"IST-2018-921-v1+1_s41467-017-02159-y.pdf","date_created":"2018-12-12T10:16:06Z","creator":"system","access_level":"open_access","relation":"main_file","file_id":"5191","date_updated":"2018-12-12T10:16:06Z","content_type":"application/pdf","file_size":2872887}],"has_accepted_license":"1","ddc":["571"],"project":[{"grant_number":"604102","name":"Localization of ion channels and receptors by two and three-dimensional immunoelectron microscopic approaches","_id":"25CD3DD2-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"},{"_id":"254D1A94-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P 25651-N26","name":"Sensitivity to higher-order statistics in natural scenes"}],"oa_version":"Published Version","publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"article_processing_charge":"No"},{"status":"public","publication_identifier":{"issn":["2041-1723"]},"scopus_import":"1","title":"Nucleolar expansion and elevated protein translation in premature aging","type":"journal_article","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","oa":1,"main_file_link":[{"url":"https://doi.org/10.1038/s41467-017-00322-z","open_access":"1"}],"article_type":"original","date_updated":"2022-07-18T08:33:03Z","abstract":[{"text":"Premature aging disorders provide an opportunity to study the mechanisms that drive aging. In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We sought to investigate protein homeostasis in this disease. Here, we report a widespread increase in protein turnover in HGPS-derived cells compared to normal cells. We determine that global protein synthesis is elevated as a consequence of activated nucleoli and enhanced ribosome biogenesis in HGPS-derived fibroblasts. Depleting normal lamin A or inducing mutant lamin A expression are each sufficient to drive nucleolar expansion. We further show that nucleolar size correlates with donor age in primary fibroblasts derived from healthy individuals and that ribosomal RNA production increases with age, indicating that nucleolar size and activity can serve as aging biomarkers. While limiting ribosome biogenesis extends lifespan in several systems, we show that increased ribosome biogenesis and activity are a hallmark of premature aging.","lang":"eng"}],"date_created":"2022-04-07T07:45:50Z","volume":8,"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry"],"publisher":"Springer Nature","_id":"11065","day":"30","citation":{"short":"A. Buchwalter, M. Hetzer, Nature Communications 8 (2017).","apa":"Buchwalter, A., &#38; Hetzer, M. (2017). Nucleolar expansion and elevated protein translation in premature aging. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-017-00322-z\">https://doi.org/10.1038/s41467-017-00322-z</a>","ama":"Buchwalter A, Hetzer M. Nucleolar expansion and elevated protein translation in premature aging. <i>Nature Communications</i>. 2017;8. doi:<a href=\"https://doi.org/10.1038/s41467-017-00322-z\">10.1038/s41467-017-00322-z</a>","mla":"Buchwalter, Abigail, and Martin Hetzer. “Nucleolar Expansion and Elevated Protein Translation in Premature Aging.” <i>Nature Communications</i>, vol. 8, 328, Springer Nature, 2017, doi:<a href=\"https://doi.org/10.1038/s41467-017-00322-z\">10.1038/s41467-017-00322-z</a>.","chicago":"Buchwalter, Abigail, and Martin Hetzer. “Nucleolar Expansion and Elevated Protein Translation in Premature Aging.” <i>Nature Communications</i>. Springer Nature, 2017. <a href=\"https://doi.org/10.1038/s41467-017-00322-z\">https://doi.org/10.1038/s41467-017-00322-z</a>.","ista":"Buchwalter A, Hetzer M. 2017. Nucleolar expansion and elevated protein translation in premature aging. Nature Communications. 8, 328.","ieee":"A. Buchwalter and M. Hetzer, “Nucleolar expansion and elevated protein translation in premature aging,” <i>Nature Communications</i>, vol. 8. Springer Nature, 2017."},"year":"2017","doi":"10.1038/s41467-017-00322-z","oa_version":"Published Version","publication_status":"published","article_processing_charge":"No","date_published":"2017-08-30T00:00:00Z","external_id":{"pmid":["28855503"]},"publication":"Nature Communications","pmid":1,"article_number":"328","quality_controlled":"1","extern":"1","author":[{"first_name":"Abigail","full_name":"Buchwalter, Abigail","last_name":"Buchwalter"},{"full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","first_name":"Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"intvolume":"         8","month":"08"},{"oa_version":"Published Version","article_processing_charge":"No","publication_status":"published","doi":"10.1101/gad.306753.117","year":"2017","quality_controlled":"1","intvolume":"        31","author":[{"full_name":"Franks, Tobias M.","first_name":"Tobias M.","last_name":"Franks"},{"last_name":"McCloskey","first_name":"Asako","full_name":"McCloskey, Asako"},{"first_name":"Maxim Nikolaievich","full_name":"Shokhirev, Maxim Nikolaievich","last_name":"Shokhirev"},{"last_name":"Benner","first_name":"Chris","full_name":"Benner, Chris"},{"last_name":"Rathore","first_name":"Annie","full_name":"Rathore, Annie"},{"orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"month":"12","extern":"1","external_id":{"pmid":["29269482"]},"publication":"Genes & Development","date_published":"2017-12-21T00:00:00Z","pmid":1,"issue":"22","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","type":"journal_article","publication_identifier":{"issn":["0890-9369","1549-5477"]},"status":"public","scopus_import":"1","title":"Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells","page":"2222-2234","keyword":["Developmental Biology","Genetics"],"citation":{"ista":"Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. 2017. Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. Genes &#38; Development. 31(22), 2222–2234.","mla":"Franks, Tobias M., et al. “Nup98 Recruits the Wdr82–Set1A/COMPASS Complex to Promoters to Regulate H3K4 Trimethylation in Hematopoietic Progenitor Cells.” <i>Genes &#38; Development</i>, vol. 31, no. 22, Cold Spring Harbor Laboratory, 2017, pp. 2222–34, doi:<a href=\"https://doi.org/10.1101/gad.306753.117\">10.1101/gad.306753.117</a>.","chicago":"Franks, Tobias M., Asako McCloskey, Maxim Nikolaievich Shokhirev, Chris Benner, Annie Rathore, and Martin Hetzer. “Nup98 Recruits the Wdr82–Set1A/COMPASS Complex to Promoters to Regulate H3K4 Trimethylation in Hematopoietic Progenitor Cells.” <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory, 2017. <a href=\"https://doi.org/10.1101/gad.306753.117\">https://doi.org/10.1101/gad.306753.117</a>.","ieee":"T. M. Franks, A. McCloskey, M. N. Shokhirev, C. Benner, A. Rathore, and M. Hetzer, “Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells,” <i>Genes &#38; Development</i>, vol. 31, no. 22. Cold Spring Harbor Laboratory, pp. 2222–2234, 2017.","apa":"Franks, T. M., McCloskey, A., Shokhirev, M. N., Benner, C., Rathore, A., &#38; Hetzer, M. (2017). Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. <i>Genes &#38; Development</i>. Cold Spring Harbor Laboratory. <a href=\"https://doi.org/10.1101/gad.306753.117\">https://doi.org/10.1101/gad.306753.117</a>","ama":"Franks TM, McCloskey A, Shokhirev MN, Benner C, Rathore A, Hetzer M. Nup98 recruits the Wdr82–Set1A/COMPASS complex to promoters to regulate H3K4 trimethylation in hematopoietic progenitor cells. <i>Genes &#38; Development</i>. 2017;31(22):2222-2234. doi:<a href=\"https://doi.org/10.1101/gad.306753.117\">10.1101/gad.306753.117</a>","short":"T.M. Franks, A. McCloskey, M.N. Shokhirev, C. Benner, A. Rathore, M. Hetzer, Genes &#38; Development 31 (2017) 2222–2234."},"day":"21","publisher":"Cold Spring Harbor Laboratory","_id":"11066","article_type":"original","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/gad.306753.117"}],"date_updated":"2022-07-18T08:33:05Z","oa":1,"language":[{"iso":"eng"}],"volume":31,"date_created":"2022-04-07T07:45:59Z","abstract":[{"lang":"eng","text":"Recent studies have shown that a subset of nucleoporins (Nups) can detach from the nuclear pore complex and move into the nuclear interior to regulate transcription. One such dynamic Nup, called Nup98, has been implicated in gene activation in healthy cells and has been shown to drive leukemogenesis when mutated in patients with acute myeloid leukemia (AML). Here we show that in hematopoietic cells, Nup98 binds predominantly to transcription start sites to recruit the Wdr82–Set1A/COMPASS (complex of proteins associated with Set1) complex, which is required for deposition of the histone 3 Lys4 trimethyl (H3K4me3)-activating mark. Depletion of Nup98 or Wdr82 abolishes Set1A recruitment to chromatin and subsequently ablates H3K4me3 at adjacent promoters. Furthermore, expression of a Nup98 fusion protein implicated in aggressive AML causes mislocalization of H3K4me3 at abnormal regions and up-regulation of associated genes. Our findings establish a function of Nup98 in hematopoietic gene activation and provide mechanistic insight into which Nup98 leukemic fusion proteins promote AML."}]},{"publication_status":"published","article_processing_charge":"No","oa_version":"Published Version","year":"2017","doi":"10.1016/j.stem.2017.08.012","extern":"1","month":"11","intvolume":"        21","author":[{"first_name":"Tomohisa","full_name":"Toda, Tomohisa","last_name":"Toda"},{"full_name":"Hsu, Jonathan Y.","first_name":"Jonathan Y.","last_name":"Hsu"},{"full_name":"Linker, Sara B.","first_name":"Sara B.","last_name":"Linker"},{"first_name":"Lauren","full_name":"Hu, Lauren","last_name":"Hu"},{"last_name":"Schafer","full_name":"Schafer, Simon T.","first_name":"Simon T."},{"full_name":"Mertens, Jerome","first_name":"Jerome","last_name":"Mertens"},{"last_name":"Jacinto","first_name":"Filipe V.","full_name":"Jacinto, Filipe V."},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","first_name":"Martin W","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W"},{"last_name":"Gage","full_name":"Gage, Fred H.","first_name":"Fred H."}],"quality_controlled":"1","pmid":1,"date_published":"2017-11-02T00:00:00Z","external_id":{"pmid":["28919367"]},"publication":"Cell Stem Cell","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","issue":"5","page":"618-634.e7","scopus_import":"1","publication_identifier":{"issn":["1934-5909"]},"title":"Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells","status":"public","type":"journal_article","publisher":"Elsevier","_id":"11067","day":"02","citation":{"ista":"Toda T, Hsu JY, Linker SB, Hu L, Schafer ST, Mertens J, Jacinto FV, Hetzer M, Gage FH. 2017. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. Cell Stem Cell. 21(5), 618–634.e7.","chicago":"Toda, Tomohisa, Jonathan Y. Hsu, Sara B. Linker, Lauren Hu, Simon T. Schafer, Jerome Mertens, Filipe V. Jacinto, Martin Hetzer, and Fred H. Gage. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.” <i>Cell Stem Cell</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">https://doi.org/10.1016/j.stem.2017.08.012</a>.","mla":"Toda, Tomohisa, et al. “Nup153 Interacts with Sox2 to Enable Bimodal Gene Regulation and Maintenance of Neural Progenitor Cells.” <i>Cell Stem Cell</i>, vol. 21, no. 5, Elsevier, 2017, p. 618–634.e7, doi:<a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">10.1016/j.stem.2017.08.012</a>.","ieee":"T. Toda <i>et al.</i>, “Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells,” <i>Cell Stem Cell</i>, vol. 21, no. 5. Elsevier, p. 618–634.e7, 2017.","short":"T. Toda, J.Y. Hsu, S.B. Linker, L. Hu, S.T. Schafer, J. Mertens, F.V. Jacinto, M. Hetzer, F.H. Gage, Cell Stem Cell 21 (2017) 618–634.e7.","apa":"Toda, T., Hsu, J. Y., Linker, S. B., Hu, L., Schafer, S. T., Mertens, J., … Gage, F. H. (2017). Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. <i>Cell Stem Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">https://doi.org/10.1016/j.stem.2017.08.012</a>","ama":"Toda T, Hsu JY, Linker SB, et al. Nup153 interacts with Sox2 to enable bimodal gene regulation and maintenance of neural progenitor cells. <i>Cell Stem Cell</i>. 2017;21(5):618-634.e7. doi:<a href=\"https://doi.org/10.1016/j.stem.2017.08.012\">10.1016/j.stem.2017.08.012</a>"},"keyword":["Cell Biology","Genetics","Molecular Medicine"],"volume":21,"abstract":[{"text":"Neural progenitor cells (NeuPCs) possess a unique nuclear architecture that changes during differentiation. Nucleoporins are linked with cell-type-specific gene regulation, coupling physical changes in nuclear structure to transcriptional output; but, whether and how they coordinate with key fate-determining transcription factors is unclear. Here we show that the nucleoporin Nup153 interacts with Sox2 in adult NeuPCs, where it is indispensable for their maintenance and controls neuronal differentiation. Genome-wide analyses show that Nup153 and Sox2 bind and co-regulate hundreds of genes. Binding of Nup153 to gene promoters or transcriptional end sites correlates with increased or decreased gene expression, respectively, and inhibiting Nup153 expression alters open chromatin configurations at its target genes, disrupts genomic localization of Sox2, and promotes differentiation in vitro and a gliogenic fate switch in vivo. Together, these findings reveal that nuclear structural proteins may exert bimodal transcriptional effects to control cell fate.","lang":"eng"}],"date_created":"2022-04-07T07:46:12Z","language":[{"iso":"eng"}],"oa":1,"main_file_link":[{"url":"https://doi.org/10.1016/j.stem.2017.08.012","open_access":"1"}],"date_updated":"2022-07-18T08:33:07Z","article_type":"original"},{"quality_controlled":"1","extern":"1","intvolume":"       323","author":[{"last_name":"Breuss","first_name":"Martin","full_name":"Breuss, Martin"},{"last_name":"Hansen","id":"38853E16-F248-11E8-B48F-1D18A9856A87","first_name":"Andi H","full_name":"Hansen, Andi H"},{"last_name":"Landler","full_name":"Landler, Lukas","first_name":"Lukas"},{"last_name":"Keays","first_name":"David","full_name":"Keays, David"}],"month":"04","date_published":"2017-04-14T00:00:00Z","publication":"Behavioural Brain Research","external_id":{"isi":["000397369100007"]},"acknowledgement":"Austrian Science Fund (FWF) for funding this research [I914,P21092]","oa_version":"Published Version","publication_status":"published","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"article_processing_charge":"No","year":"2017","doi":"10.1016/j.bbr.2017.01.029","has_accepted_license":"1","file":[{"date_created":"2018-12-12T10:12:03Z","file_name":"IST-2017-868-v1+1_1-s2.0-S0166432816309160-main.pdf","creator":"system","access_level":"open_access","relation":"main_file","date_updated":"2018-12-12T10:12:03Z","file_id":"4921","content_type":"application/pdf","file_size":2291511}],"ddc":["570","571"],"_id":"1107","publisher":"Elsevier","pubrep_id":"868","day":"14","citation":{"short":"M. Breuss, A.H. Hansen, L. Landler, D. Keays, Behavioural Brain Research 323 (2017) 47–55.","apa":"Breuss, M., Hansen, A. H., Landler, L., &#38; Keays, D. (2017). Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. <i>Behavioural Brain Research</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">https://doi.org/10.1016/j.bbr.2017.01.029</a>","ama":"Breuss M, Hansen AH, Landler L, Keays D. Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. <i>Behavioural Brain Research</i>. 2017;323:47-55. doi:<a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">10.1016/j.bbr.2017.01.029</a>","mla":"Breuss, Martin, et al. “Brain Specific Knockin of the Pathogenic Tubb5 E401K Allele Causes Defects in Motor Coordination and Prepulse Inhibition.” <i>Behavioural Brain Research</i>, vol. 323, Elsevier, 2017, pp. 47–55, doi:<a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">10.1016/j.bbr.2017.01.029</a>.","chicago":"Breuss, Martin, Andi H Hansen, Lukas Landler, and David Keays. “Brain Specific Knockin of the Pathogenic Tubb5 E401K Allele Causes Defects in Motor Coordination and Prepulse Inhibition.” <i>Behavioural Brain Research</i>. Elsevier, 2017. <a href=\"https://doi.org/10.1016/j.bbr.2017.01.029\">https://doi.org/10.1016/j.bbr.2017.01.029</a>.","ista":"Breuss M, Hansen AH, Landler L, Keays D. 2017. Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition. Behavioural Brain Research. 323, 47–55.","ieee":"M. Breuss, A. H. Hansen, L. Landler, and D. Keays, “Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition,” <i>Behavioural Brain Research</i>, vol. 323. Elsevier, pp. 47–55, 2017."},"oa":1,"isi":1,"date_updated":"2023-09-20T11:37:25Z","volume":323,"abstract":[{"text":"The generation, migration, and differentiation of neurons requires the functional integrity of the microtubule cytoskeleton. Mutations in the tubulin gene family are known to cause various neurological diseases including lissencephaly, ocular motor disorders, polymicrogyria and amyotrophic lateral sclerosis. We have previously reported that mutations in TUBB5 cause microcephaly that is accompanied by severe intellectual impairment and motor delay. Here we present the characterization of a Tubb5 mouse model that allows for the conditional expression of the pathogenic E401K mutation. Homozygous knockin animals exhibit a severe reduction in brain size and in body weight. These animals do not show any significant impairment in general activity, anxiety, or in the acoustic startle response, however, present with notable defects in motor coordination. When assessed on the static rod apparatus mice took longer to orient and often lost their balance completely. Interestingly, mutant animals also showed defects in prepulse inhibition, a phenotype associated with sensorimotor gating and considered an endophenotype for schizophrenia. This study provides insight into the behavioral consequences of tubulin gene mutations.","lang":"eng"}],"date_created":"2018-12-11T11:50:11Z","language":[{"iso":"eng"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file_date_updated":"2018-12-12T10:12:03Z","page":"47 - 55","title":"Brain specific knockin of the pathogenic Tubb5 E401K allele causes defects in motor coordination and prepulse inhibition","status":"public","publication_identifier":{"issn":["01664328"]},"type":"journal_article","publist_id":"6262"}]