[{"project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","grant_number":"742985","call_identifier":"H2020"},{"_id":"26538374-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of endocytic cargo recognition in plants","call_identifier":"FWF","grant_number":"I03630"},{"_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734","call_identifier":"FP7"}],"publication_status":"published","citation":{"apa":"Zhang, Y., Hartinger, C., Wang, X., &#38; Friml, J. (2020). Directional auxin fluxes in plants by intramolecular domain‐domain co‐evolution of PIN auxin transporters. <i>New Phytologist</i>. Wiley. <a href=\"https://doi.org/10.1111/nph.16629\">https://doi.org/10.1111/nph.16629</a>","mla":"Zhang, Yuzhou, et al. “Directional Auxin Fluxes in Plants by Intramolecular Domain‐domain Co‐evolution of PIN Auxin Transporters.” <i>New Phytologist</i>, vol. 227, no. 5, Wiley, 2020, pp. 1406–16, doi:<a href=\"https://doi.org/10.1111/nph.16629\">10.1111/nph.16629</a>.","ieee":"Y. Zhang, C. Hartinger, X. Wang, and J. Friml, “Directional auxin fluxes in plants by intramolecular domain‐domain co‐evolution of PIN auxin transporters,” <i>New Phytologist</i>, vol. 227, no. 5. Wiley, pp. 1406–1416, 2020.","ista":"Zhang Y, Hartinger C, Wang X, Friml J. 2020. Directional auxin fluxes in plants by intramolecular domain‐domain co‐evolution of PIN auxin transporters. New Phytologist. 227(5), 1406–1416.","short":"Y. Zhang, C. Hartinger, X. Wang, J. Friml, New Phytologist 227 (2020) 1406–1416.","ama":"Zhang Y, Hartinger C, Wang X, Friml J. Directional auxin fluxes in plants by intramolecular domain‐domain co‐evolution of PIN auxin transporters. <i>New Phytologist</i>. 2020;227(5):1406-1416. doi:<a href=\"https://doi.org/10.1111/nph.16629\">10.1111/nph.16629</a>","chicago":"Zhang, Yuzhou, Corinna Hartinger, Xiaojuan Wang, and Jiří Friml. “Directional Auxin Fluxes in Plants by Intramolecular Domain‐domain Co‐evolution of PIN Auxin Transporters.” <i>New Phytologist</i>. Wiley, 2020. <a href=\"https://doi.org/10.1111/nph.16629\">https://doi.org/10.1111/nph.16629</a>."},"publication_identifier":{"issn":["0028-646X"],"eissn":["1469-8137"]},"abstract":[{"text":"* Morphogenesis and adaptive tropic growth in plants depend on gradients of the phytohormone auxin, mediated by the membrane‐based PIN‐FORMED (PIN) auxin transporters. PINs localize to a particular side of the plasma membrane (PM) or to the endoplasmic reticulum (ER) to directionally transport auxin and maintain intercellular and intracellular auxin homeostasis, respectively. However, the molecular cues that confer their diverse cellular localizations remain largely unknown.\r\n* In this study, we systematically swapped the domains between ER‐ and PM‐localized PIN proteins, as well as between apical and basal PM‐localized PINs from Arabidopsis thaliana , to shed light on why PIN family members with similar topological structures reside at different membrane compartments within cells.\r\n* Our results show that not only do the N‐ and C‐terminal transmembrane domains (TMDs) and central hydrophilic loop contribute to their differential subcellular localizations and cellular polarity, but that the pairwise‐matched N‐ and C‐terminal TMDs resulting from intramolecular domain–domain coevolution are also crucial for their divergent patterns of localization.\r\n* These findings illustrate the complexity of the evolutionary path of PIN proteins in acquiring their plethora of developmental functions and adaptive growth in plants.","lang":"eng"}],"scopus_import":"1","type":"journal_article","file_date_updated":"2020-11-24T12:19:38Z","_id":"7697","quality_controlled":"1","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"JiFr"}],"language":[{"iso":"eng"}],"article_type":"original","has_accepted_license":"1","publisher":"Wiley","author":[{"first_name":"Yuzhou","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2627-6956","last_name":"Zhang","full_name":"Zhang, Yuzhou"},{"orcid":"0000-0003-1618-2737","last_name":"Hartinger","first_name":"Corinna","id":"AEFB2266-8ABF-11EA-AA39-812C3623CBE4","full_name":"Hartinger, Corinna"},{"first_name":"Xiaojuan","last_name":"Wang","full_name":"Wang, Xiaojuan"},{"first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jiří"}],"title":"Directional auxin fluxes in plants by intramolecular domain‐domain co‐evolution of PIN auxin transporters","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file":[{"file_size":3643395,"creator":"dernst","content_type":"application/pdf","file_id":"8799","access_level":"open_access","relation":"main_file","checksum":"8e8150dbbba8cb65b72f81d1f0864b8b","file_name":"2020_09_NewPhytologist_Zhang.pdf","success":1,"date_updated":"2020-11-24T12:19:38Z","date_created":"2020-11-24T12:19:38Z"}],"publication":"New Phytologist","doi":"10.1111/nph.16629","ec_funded":1,"oa_version":"Published Version","isi":1,"volume":227,"pmid":1,"date_created":"2020-04-30T08:43:29Z","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["580"],"day":"01","status":"public","page":"1406-1416","external_id":{"pmid":["32350870"],"isi":["000534092400001"]},"license":"https://creativecommons.org/licenses/by/4.0/","year":"2020","date_published":"2020-09-01T00:00:00Z","month":"09","intvolume":"       227","date_updated":"2023-09-05T15:46:04Z","oa":1,"issue":"5"},{"date_published":"2020-03-20T00:00:00Z","month":"03","intvolume":"        11","article_number":"1385","publisher":"Springer Nature","date_updated":"2021-01-12T08:14:59Z","author":[{"first_name":"Jonathan","last_name":"Sulc","full_name":"Sulc, Jonathan"},{"full_name":"Mounier, Ninon","last_name":"Mounier","first_name":"Ninon"},{"full_name":"Günther, Felix","first_name":"Felix","last_name":"Günther"},{"first_name":"Thomas","last_name":"Winkler","full_name":"Winkler, Thomas"},{"full_name":"Wood, Andrew R.","first_name":"Andrew R.","last_name":"Wood"},{"full_name":"Frayling, Timothy M.","last_name":"Frayling","first_name":"Timothy M."},{"full_name":"Heid, Iris M.","first_name":"Iris M.","last_name":"Heid"},{"full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"},{"first_name":"Zoltán","last_name":"Kutalik","full_name":"Kutalik, Zoltán"}],"oa":1,"title":"Quantification of the overall contribution of gene-environment interaction for obesity-related traits","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","language":[{"iso":"eng"}],"article_type":"original","year":"2020","volume":11,"publication_identifier":{"issn":["2041-1723"]},"citation":{"mla":"Sulc, Jonathan, et al. “Quantification of the Overall Contribution of Gene-Environment Interaction for Obesity-Related Traits.” <i>Nature Communications</i>, vol. 11, 1385, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-15107-0\">10.1038/s41467-020-15107-0</a>.","apa":"Sulc, J., Mounier, N., Günther, F., Winkler, T., Wood, A. R., Frayling, T. M., … Kutalik, Z. (2020). Quantification of the overall contribution of gene-environment interaction for obesity-related traits. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-15107-0\">https://doi.org/10.1038/s41467-020-15107-0</a>","chicago":"Sulc, Jonathan, Ninon Mounier, Felix Günther, Thomas Winkler, Andrew R. Wood, Timothy M. Frayling, Iris M. Heid, Matthew Richard Robinson, and Zoltán Kutalik. “Quantification of the Overall Contribution of Gene-Environment Interaction for Obesity-Related Traits.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-15107-0\">https://doi.org/10.1038/s41467-020-15107-0</a>.","ieee":"J. Sulc <i>et al.</i>, “Quantification of the overall contribution of gene-environment interaction for obesity-related traits,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","ista":"Sulc J, Mounier N, Günther F, Winkler T, Wood AR, Frayling TM, Heid IM, Robinson MR, Kutalik Z. 2020. Quantification of the overall contribution of gene-environment interaction for obesity-related traits. Nature Communications. 11, 1385.","short":"J. Sulc, N. Mounier, F. Günther, T. Winkler, A.R. Wood, T.M. Frayling, I.M. Heid, M.R. Robinson, Z. Kutalik, Nature Communications 11 (2020).","ama":"Sulc J, Mounier N, Günther F, et al. Quantification of the overall contribution of gene-environment interaction for obesity-related traits. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-15107-0\">10.1038/s41467-020-15107-0</a>"},"extern":"1","abstract":[{"lang":"eng","text":"The growing sample size of genome-wide association studies has facilitated the discovery of gene-environment interactions (GxE). Here we propose a maximum likelihood method to estimate the contribution of GxE to continuous traits taking into account all interacting environmental variables, without the need to measure any. Extensive simulations demonstrate that our method provides unbiased interaction estimates and excellent coverage. We also offer strategies to distinguish specific GxE from general scale effects. Applying our method to 32 traits in the UK Biobank reveals that while the genetic risk score (GRS) of 376 variants explains 5.2% of body mass index (BMI) variance, GRSxE explains an additional 1.9%. Nevertheless, this interaction holds for any variable with identical correlation to BMI as the GRS, hence may not be GRS-specific. Still, we observe that the global contribution of specific GRSxE to complex traits is substantial for nine obesity-related measures (including leg impedance and trunk fat-free mass)."}],"type":"journal_article","_id":"7707","date_created":"2020-04-30T10:39:33Z","day":"20","quality_controlled":"1","status":"public","publication":"Nature Communications","doi":"10.1038/s41467-020-15107-0","publication_status":"published","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-020-15107-0"}],"oa_version":"Published Version"},{"oa_version":"Published Version","publication":"npj Genomic Medicine","main_file_link":[{"url":"https://doi.org/10.1038/s41525-020-0118-3","open_access":"1"}],"doi":"10.1038/s41525-020-0118-3","publication_status":"published","date_created":"2020-04-30T10:39:54Z","_id":"7708","quality_controlled":"1","status":"public","day":"27","volume":5,"citation":{"mla":"Nabais, Marta F., et al. “Significant Out-of-Sample Classification from Methylation Profile Scoring for Amyotrophic Lateral Sclerosis.” <i>Npj Genomic Medicine</i>, vol. 5, 10, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41525-020-0118-3\">10.1038/s41525-020-0118-3</a>.","apa":"Nabais, M. F., Lin, T., Benyamin, B., Williams, K. L., Garton, F. C., Vinkhuyzen, A. A. E., … Wray, N. R. (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. <i>Npj Genomic Medicine</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41525-020-0118-3\">https://doi.org/10.1038/s41525-020-0118-3</a>","chicago":"Nabais, Marta F., Tian Lin, Beben Benyamin, Kelly L. Williams, Fleur C. Garton, Anna A. E. Vinkhuyzen, Futao Zhang, et al. “Significant Out-of-Sample Classification from Methylation Profile Scoring for Amyotrophic Lateral Sclerosis.” <i>Npj Genomic Medicine</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41525-020-0118-3\">https://doi.org/10.1038/s41525-020-0118-3</a>.","ama":"Nabais MF, Lin T, Benyamin B, et al. Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. <i>npj Genomic Medicine</i>. 2020;5. doi:<a href=\"https://doi.org/10.1038/s41525-020-0118-3\">10.1038/s41525-020-0118-3</a>","short":"M.F. Nabais, T. Lin, B. Benyamin, K.L. Williams, F.C. Garton, A.A.E. Vinkhuyzen, F. Zhang, C.L. Vallerga, R. Restuadi, A. Freydenzon, R.A.J. Zwamborn, P.J. Hop, M.R. Robinson, J. Gratten, P.M. Visscher, E. Hannon, J. Mill, M.A. Brown, N.G. Laing, K.A. Mather, P.S. Sachdev, S.T. Ngo, F.J. Steyn, L. Wallace, A.K. Henders, M. Needham, J.H. Veldink, S. Mathers, G. Nicholson, D.B. Rowe, R.D. Henderson, P.A. McCombe, R. Pamphlett, J. Yang, I.P. Blair, A.F. McRae, N.R. Wray, Npj Genomic Medicine 5 (2020).","ieee":"M. F. Nabais <i>et al.</i>, “Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis,” <i>npj Genomic Medicine</i>, vol. 5. Springer Nature, 2020.","ista":"Nabais MF, Lin T, Benyamin B, Williams KL, Garton FC, Vinkhuyzen AAE, Zhang F, Vallerga CL, Restuadi R, Freydenzon A, Zwamborn RAJ, Hop PJ, Robinson MR, Gratten J, Visscher PM, Hannon E, Mill J, Brown MA, Laing NG, Mather KA, Sachdev PS, Ngo ST, Steyn FJ, Wallace L, Henders AK, Needham M, Veldink JH, Mathers S, Nicholson G, Rowe DB, Henderson RD, McCombe PA, Pamphlett R, Yang J, Blair IP, McRae AF, Wray NR. 2020. Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine. 5, 10."},"publication_identifier":{"issn":["2056-7944"]},"extern":"1","abstract":[{"lang":"eng","text":"We conducted DNA methylation association analyses using Illumina 450K data from whole blood for an Australian amyotrophic lateral sclerosis (ALS) case–control cohort (782 cases and 613 controls). Analyses used mixed linear models as implemented in the OSCA software. We found a significantly higher proportion of neutrophils in cases compared to controls which replicated in an independent cohort from the Netherlands (1159 cases and 637 controls). The OSCA MOMENT linear mixed model has been shown in simulations to best account for confounders. When combined in a methylation profile score, the 25 most-associated probes identified by MOMENT significantly classified case–control status in the Netherlands sample (area under the curve, AUC = 0.65, CI95% = [0.62–0.68], p = 8.3 × 10−22). The maximum AUC achieved was 0.69 (CI95% = [0.66–0.71], p = 4.3 × 10−34) when cell-type proportion was included in the predictor."}],"type":"journal_article","language":[{"iso":"eng"}],"article_type":"original","year":"2020","article_processing_charge":"No","date_updated":"2021-01-12T08:14:59Z","title":"Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"author":[{"first_name":"Marta F.","last_name":"Nabais","full_name":"Nabais, Marta F."},{"last_name":"Lin","first_name":"Tian","full_name":"Lin, Tian"},{"full_name":"Benyamin, Beben","first_name":"Beben","last_name":"Benyamin"},{"full_name":"Williams, Kelly L.","last_name":"Williams","first_name":"Kelly L."},{"first_name":"Fleur C.","last_name":"Garton","full_name":"Garton, Fleur C."},{"last_name":"Vinkhuyzen","first_name":"Anna A. E.","full_name":"Vinkhuyzen, Anna A. E."},{"first_name":"Futao","last_name":"Zhang","full_name":"Zhang, Futao"},{"last_name":"Vallerga","first_name":"Costanza L.","full_name":"Vallerga, Costanza L."},{"full_name":"Restuadi, Restuadi","first_name":"Restuadi","last_name":"Restuadi"},{"first_name":"Anna","last_name":"Freydenzon","full_name":"Freydenzon, Anna"},{"first_name":"Ramona A. J.","last_name":"Zwamborn","full_name":"Zwamborn, Ramona A. J."},{"first_name":"Paul J.","last_name":"Hop","full_name":"Hop, Paul J."},{"last_name":"Robinson","orcid":"0000-0001-8982-8813","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","full_name":"Robinson, Matthew Richard"},{"full_name":"Gratten, Jacob","first_name":"Jacob","last_name":"Gratten"},{"last_name":"Visscher","first_name":"Peter M.","full_name":"Visscher, Peter M."},{"first_name":"Eilis","last_name":"Hannon","full_name":"Hannon, Eilis"},{"first_name":"Jonathan","last_name":"Mill","full_name":"Mill, Jonathan"},{"last_name":"Brown","first_name":"Matthew A.","full_name":"Brown, Matthew A."},{"first_name":"Nigel G.","last_name":"Laing","full_name":"Laing, Nigel G."},{"full_name":"Mather, Karen A.","last_name":"Mather","first_name":"Karen A."},{"full_name":"Sachdev, Perminder S.","first_name":"Perminder S.","last_name":"Sachdev"},{"full_name":"Ngo, Shyuan T.","first_name":"Shyuan T.","last_name":"Ngo"},{"last_name":"Steyn","first_name":"Frederik J.","full_name":"Steyn, Frederik J."},{"full_name":"Wallace, Leanne","first_name":"Leanne","last_name":"Wallace"},{"full_name":"Henders, Anjali K.","first_name":"Anjali K.","last_name":"Henders"},{"last_name":"Needham","first_name":"Merrilee","full_name":"Needham, Merrilee"},{"last_name":"Veldink","first_name":"Jan H.","full_name":"Veldink, Jan H."},{"full_name":"Mathers, Susan","first_name":"Susan","last_name":"Mathers"},{"full_name":"Nicholson, Garth","last_name":"Nicholson","first_name":"Garth"},{"full_name":"Rowe, Dominic B.","first_name":"Dominic B.","last_name":"Rowe"},{"first_name":"Robert D.","last_name":"Henderson","full_name":"Henderson, Robert D."},{"full_name":"McCombe, Pamela A.","last_name":"McCombe","first_name":"Pamela A."},{"last_name":"Pamphlett","first_name":"Roger","full_name":"Pamphlett, Roger"},{"last_name":"Yang","first_name":"Jian","full_name":"Yang, Jian"},{"full_name":"Blair, Ian P.","last_name":"Blair","first_name":"Ian P."},{"full_name":"McRae, Allan F.","first_name":"Allan F.","last_name":"McRae"},{"full_name":"Wray, Naomi R.","last_name":"Wray","first_name":"Naomi R."}],"date_published":"2020-02-27T00:00:00Z","month":"02","intvolume":"         5","publisher":"Springer Nature","article_number":"10"},{"publication_status":"published","_id":"5681","quality_controlled":"1","publication_identifier":{"eissn":["19410506"],"issn":["10772626"]},"citation":{"apa":"Hikaru, I., Wojtan, C., Thuerey, N., Igarashi, T., &#38; Ando, R. (2020). Simulating liquids on dynamically warping grids. <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE. <a href=\"https://doi.org/10.1109/TVCG.2018.2883628\">https://doi.org/10.1109/TVCG.2018.2883628</a>","mla":"Hikaru, Ibayashi, et al. “Simulating Liquids on Dynamically Warping Grids.” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 26, no. 6, IEEE, 2020, pp. 2288–302, doi:<a href=\"https://doi.org/10.1109/TVCG.2018.2883628\">10.1109/TVCG.2018.2883628</a>.","short":"I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, R. Ando, IEEE Transactions on Visualization and Computer Graphics 26 (2020) 2288–2302.","ista":"Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. 2020. Simulating liquids on dynamically warping grids. IEEE Transactions on Visualization and Computer Graphics. 26(6), 2288–2302.","ieee":"I. Hikaru, C. Wojtan, N. Thuerey, T. Igarashi, and R. Ando, “Simulating liquids on dynamically warping grids,” <i>IEEE Transactions on Visualization and Computer Graphics</i>, vol. 26, no. 6. IEEE, pp. 2288–2302, 2020.","ama":"Hikaru I, Wojtan C, Thuerey N, Igarashi T, Ando R. Simulating liquids on dynamically warping grids. <i>IEEE Transactions on Visualization and Computer Graphics</i>. 2020;26(6):2288-2302. doi:<a href=\"https://doi.org/10.1109/TVCG.2018.2883628\">10.1109/TVCG.2018.2883628</a>","chicago":"Hikaru, Ibayashi, Chris Wojtan, Nils Thuerey, Takeo Igarashi, and Ryoichi Ando. “Simulating Liquids on Dynamically Warping Grids.” <i>IEEE Transactions on Visualization and Computer Graphics</i>. IEEE, 2020. <a href=\"https://doi.org/10.1109/TVCG.2018.2883628\">https://doi.org/10.1109/TVCG.2018.2883628</a>."},"scopus_import":"1","abstract":[{"text":"We introduce dynamically warping grids for adaptive liquid simulation. Our primary contributions are a strategy for dynamically deforming regular grids over the course of a simulation and a method for efficiently utilizing these deforming grids for liquid simulation. Prior work has shown that unstructured grids are very effective for adaptive fluid simulations. However, unstructured grids often lead to complicated implementations and a poor cache hit rate due to inconsistent memory access. Regular grids, on the other hand, provide a fast, fixed memory access pattern and straightforward implementation. Our method combines the advantages of both: we leverage the simplicity of regular grids while still achieving practical and controllable spatial adaptivity. We demonstrate that our method enables adaptive simulations that are fast, flexible, and robust to null-space issues. At the same time, our method is simple to implement and takes advantage of existing highly-tuned algorithms.","lang":"eng"}],"file_date_updated":"2020-10-08T08:34:53Z","type":"journal_article","language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"No","department":[{"_id":"ChWo"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"last_name":"Hikaru","first_name":"Ibayashi","full_name":"Hikaru, Ibayashi"},{"full_name":"Wojtan, Christopher J","id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher J","orcid":"0000-0001-6646-5546","last_name":"Wojtan"},{"full_name":"Thuerey, Nils","first_name":"Nils","last_name":"Thuerey"},{"full_name":"Igarashi, Takeo","first_name":"Takeo","last_name":"Igarashi"},{"first_name":"Ryoichi","last_name":"Ando","full_name":"Ando, Ryoichi"}],"title":"Simulating liquids on dynamically warping grids","file":[{"date_created":"2020-10-08T08:34:53Z","date_updated":"2020-10-08T08:34:53Z","success":1,"file_name":"preprint.pdf","relation":"main_file","access_level":"open_access","checksum":"8d4c55443a0ee335bb5bb652de503042","file_id":"8626","content_type":"application/pdf","file_size":21910098,"creator":"wojtan"}],"has_accepted_license":"1","publisher":"IEEE","oa_version":"Submitted Version","isi":1,"publication":"IEEE Transactions on Visualization and Computer Graphics","doi":"10.1109/TVCG.2018.2883628","date_created":"2018-12-16T22:59:21Z","ddc":["006"],"day":"01","status":"public","volume":26,"pmid":1,"year":"2020","external_id":{"pmid":["30507534"],"isi":["000532295600014"]},"page":"2288-2302","date_updated":"2023-09-18T09:30:01Z","acknowledged_ssus":[{"_id":"ScienComp"}],"oa":1,"issue":"6","date_published":"2020-06-01T00:00:00Z","intvolume":"        26","month":"06","acknowledgement":"This work was partially supported by JSPS Grant-in-Aid forYoung Scientists (Start-up) 16H07410, the ERC StartingGrantsrealFlow(StG-2015-637014) andBigSplash(StG-2014-638176). This research was supported by the Scientific Ser-vice Units (SSU) of IST Austria through resources providedby Scientific Computing. We would like to express my grati-tude to Nobuyuki Umetani and Tomas Skrivan for insight-ful discussion."},{"_id":"6184","quality_controlled":"1","citation":{"chicago":"Alt, Johannes, László Erdös, Torben H Krüger, and Dominik J Schröder. “Correlated Random Matrices: Band Rigidity and Edge Universality.” <i>Annals of Probability</i>. Institute of Mathematical Statistics, 2020. <a href=\"https://doi.org/10.1214/19-AOP1379\">https://doi.org/10.1214/19-AOP1379</a>.","short":"J. Alt, L. Erdös, T.H. Krüger, D.J. Schröder, Annals of Probability 48 (2020) 963–1001.","ista":"Alt J, Erdös L, Krüger TH, Schröder DJ. 2020. Correlated random matrices: Band rigidity and edge universality. Annals of Probability. 48(2), 963–1001.","ieee":"J. Alt, L. Erdös, T. H. Krüger, and D. J. Schröder, “Correlated random matrices: Band rigidity and edge universality,” <i>Annals of Probability</i>, vol. 48, no. 2. Institute of Mathematical Statistics, pp. 963–1001, 2020.","ama":"Alt J, Erdös L, Krüger TH, Schröder DJ. Correlated random matrices: Band rigidity and edge universality. <i>Annals of Probability</i>. 2020;48(2):963-1001. doi:<a href=\"https://doi.org/10.1214/19-AOP1379\">10.1214/19-AOP1379</a>","mla":"Alt, Johannes, et al. “Correlated Random Matrices: Band Rigidity and Edge Universality.” <i>Annals of Probability</i>, vol. 48, no. 2, Institute of Mathematical Statistics, 2020, pp. 963–1001, doi:<a href=\"https://doi.org/10.1214/19-AOP1379\">10.1214/19-AOP1379</a>.","apa":"Alt, J., Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2020). Correlated random matrices: Band rigidity and edge universality. <i>Annals of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/19-AOP1379\">https://doi.org/10.1214/19-AOP1379</a>"},"publication_identifier":{"issn":["0091-1798"]},"type":"journal_article","scopus_import":"1","arxiv":1,"abstract":[{"lang":"eng","text":"We prove edge universality for a general class of correlated real symmetric or complex Hermitian Wigner matrices with arbitrary expectation. Our theorem also applies to internal edges of the self-consistent density of states. In particular, we establish a strong form of band rigidity which excludes mismatches between location and label of eigenvalues close to internal edges in these general models."}],"project":[{"name":"Random matrices, universality and disordered quantum systems","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"338804"}],"publication_status":"published","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","title":"Correlated random matrices: Band rigidity and edge universality","author":[{"first_name":"Johannes","id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","last_name":"Alt","full_name":"Alt, Johannes"},{"full_name":"Erdös, László","last_name":"Erdös","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László"},{"last_name":"Krüger","orcid":"0000-0002-4821-3297","id":"3020C786-F248-11E8-B48F-1D18A9856A87","first_name":"Torben H","full_name":"Krüger, Torben H"},{"full_name":"Schröder, Dominik J","last_name":"Schröder","orcid":"0000-0002-2904-1856","id":"408ED176-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik J"}],"publisher":"Institute of Mathematical Statistics","language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"No","department":[{"_id":"LaEr"}],"date_created":"2019-03-28T09:20:08Z","status":"public","day":"01","volume":48,"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"149"},{"id":"6179","status":"public","relation":"dissertation_contains"}]},"isi":1,"ec_funded":1,"oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1804.07744"}],"doi":"10.1214/19-AOP1379","publication":"Annals of Probability","date_updated":"2024-02-22T14:34:33Z","issue":"2","oa":1,"intvolume":"        48","month":"03","date_published":"2020-03-01T00:00:00Z","year":"2020","external_id":{"isi":["000528269100013"],"arxiv":["1804.07744"]},"page":"963-1001"},{"year":"2020","external_id":{"arxiv":["1809.03971"],"isi":["000529483000001"]},"page":"1203-1278","date_updated":"2023-09-07T12:54:12Z","oa":1,"date_published":"2020-09-01T00:00:00Z","month":"09","intvolume":"       378","acknowledgement":"Open access funding provided by Institute of Science and Technology (IST Austria). The authors are very grateful to Johannes Alt for numerous discussions on the Dyson equation and for his invaluable help in adjusting [10] to the needs of the present work.","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"6179"}]},"ec_funded":1,"oa_version":"Published Version","isi":1,"publication":"Communications in Mathematical Physics","doi":"10.1007/s00220-019-03657-4","ddc":["530","510"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2019-03-28T10:21:15Z","day":"01","status":"public","volume":378,"language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"LaEr"}],"title":"Cusp universality for random matrices I: Local law and the complex Hermitian case","author":[{"orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László"},{"full_name":"Krüger, Torben H","orcid":"0000-0002-4821-3297","last_name":"Krüger","first_name":"Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-2904-1856","last_name":"Schröder","first_name":"Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","full_name":"Schröder, Dominik J"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file":[{"success":1,"file_name":"2020_CommMathPhysics_Erdoes.pdf","date_created":"2020-11-18T11:14:37Z","date_updated":"2020-11-18T11:14:37Z","file_id":"8771","content_type":"application/pdf","file_size":2904574,"creator":"dernst","relation":"main_file","checksum":"c3a683e2afdcea27afa6880b01e53dc2","access_level":"open_access"}],"has_accepted_license":"1","publisher":"Springer Nature","project":[{"name":"Random matrices, universality and disordered quantum systems","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","call_identifier":"FP7"},{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"publication_status":"published","_id":"6185","quality_controlled":"1","citation":{"apa":"Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2020). Cusp universality for random matrices I: Local law and the complex Hermitian case. <i>Communications in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00220-019-03657-4\">https://doi.org/10.1007/s00220-019-03657-4</a>","mla":"Erdös, László, et al. “Cusp Universality for Random Matrices I: Local Law and the Complex Hermitian Case.” <i>Communications in Mathematical Physics</i>, vol. 378, Springer Nature, 2020, pp. 1203–78, doi:<a href=\"https://doi.org/10.1007/s00220-019-03657-4\">10.1007/s00220-019-03657-4</a>.","short":"L. Erdös, T.H. Krüger, D.J. Schröder, Communications in Mathematical Physics 378 (2020) 1203–1278.","ieee":"L. Erdös, T. H. Krüger, and D. J. Schröder, “Cusp universality for random matrices I: Local law and the complex Hermitian case,” <i>Communications in Mathematical Physics</i>, vol. 378. Springer Nature, pp. 1203–1278, 2020.","ista":"Erdös L, Krüger TH, Schröder DJ. 2020. Cusp universality for random matrices I: Local law and the complex Hermitian case. Communications in Mathematical Physics. 378, 1203–1278.","ama":"Erdös L, Krüger TH, Schröder DJ. Cusp universality for random matrices I: Local law and the complex Hermitian case. <i>Communications in Mathematical Physics</i>. 2020;378:1203-1278. doi:<a href=\"https://doi.org/10.1007/s00220-019-03657-4\">10.1007/s00220-019-03657-4</a>","chicago":"Erdös, László, Torben H Krüger, and Dominik J Schröder. “Cusp Universality for Random Matrices I: Local Law and the Complex Hermitian Case.” <i>Communications in Mathematical Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s00220-019-03657-4\">https://doi.org/10.1007/s00220-019-03657-4</a>."},"publication_identifier":{"issn":["0010-3616"],"eissn":["1432-0916"]},"abstract":[{"lang":"eng","text":"For complex Wigner-type matrices, i.e. Hermitian random matrices with independent, not necessarily identically distributed entries above the diagonal, we show that at any cusp singularity of the limiting eigenvalue distribution the local eigenvalue statistics are universal and form a Pearcey process. Since the density of states typically exhibits only square root or cubic root cusp singularities, our work complements previous results on the bulk and edge universality and it thus completes the resolution of the Wigner–Dyson–Mehta universality conjecture for the last remaining universality type in the complex Hermitian class. Our analysis holds not only for exact cusps, but approximate cusps as well, where an extended Pearcey process emerges. As a main technical ingredient we prove an optimal local law at the cusp for both symmetry classes. This result is also the key input in the companion paper (Cipolloni et al. in Pure Appl Anal, 2018. arXiv:1811.04055) where the cusp universality for real symmetric Wigner-type matrices is proven. The novel cusp fluctuation mechanism is also essential for the recent results on the spectral radius of non-Hermitian random matrices (Alt et al. in Spectral radius of random matrices with independent entries, 2019. arXiv:1907.13631), and the non-Hermitian edge universality (Cipolloni et al. in Edge universality for non-Hermitian random matrices, 2019. arXiv:1908.00969)."}],"arxiv":1,"scopus_import":"1","file_date_updated":"2020-11-18T11:14:37Z","type":"journal_article"},{"external_id":{"isi":["000498933300001"],"arxiv":["1811.04572"]},"page":"319-378","year":"2020","date_published":"2020-01-01T00:00:00Z","month":"01","intvolume":"       178","date_updated":"2023-08-17T13:49:40Z","oa":1,"issue":"2","publication":"Journal of Statistical Physics","doi":"10.1007/s10955-019-02434-w","related_material":{"link":[{"url":"https://doi.org/10.1007/s10955-020-02671-4","relation":"erratum"}]},"oa_version":"Published Version","ec_funded":1,"isi":1,"volume":178,"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["500"],"date_created":"2019-04-30T07:34:18Z","day":"01","status":"public","article_processing_charge":"Yes (via OA deal)","department":[{"_id":"JaMa"}],"language":[{"iso":"eng"}],"article_type":"original","has_accepted_license":"1","publisher":"Springer Nature","title":"Non-commutative calculus, optimal transport and functional inequalities  in dissipative quantum systems","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"last_name":"Carlen","first_name":"Eric A.","full_name":"Carlen, Eric A."},{"first_name":"Jan","id":"4C5696CE-F248-11E8-B48F-1D18A9856A87","last_name":"Maas","orcid":"0000-0002-0845-1338","full_name":"Maas, Jan"}],"file":[{"file_name":"2019_JourStatistPhysics_Carlen.pdf","date_updated":"2020-07-14T12:47:28Z","date_created":"2019-12-23T12:03:09Z","file_id":"7209","content_type":"application/pdf","creator":"dernst","file_size":905538,"checksum":"7b04befbdc0d4982c0ee945d25d19872","access_level":"open_access","relation":"main_file"}],"project":[{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"},{"grant_number":"716117","call_identifier":"H2020","_id":"256E75B8-B435-11E9-9278-68D0E5697425","name":"Optimal Transport and Stochastic Dynamics"},{"grant_number":" F06504","call_identifier":"FWF","_id":"260482E2-B435-11E9-9278-68D0E5697425","name":"Taming Complexity in Partial Di erential Systems"}],"publication_status":"published","publication_identifier":{"issn":["00224715"],"eissn":["15729613"]},"citation":{"apa":"Carlen, E. A., &#38; Maas, J. (2020). Non-commutative calculus, optimal transport and functional inequalities  in dissipative quantum systems. <i>Journal of Statistical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10955-019-02434-w\">https://doi.org/10.1007/s10955-019-02434-w</a>","mla":"Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport and Functional Inequalities  in Dissipative Quantum Systems.” <i>Journal of Statistical Physics</i>, vol. 178, no. 2, Springer Nature, 2020, pp. 319–78, doi:<a href=\"https://doi.org/10.1007/s10955-019-02434-w\">10.1007/s10955-019-02434-w</a>.","short":"E.A. Carlen, J. Maas, Journal of Statistical Physics 178 (2020) 319–378.","ieee":"E. A. Carlen and J. Maas, “Non-commutative calculus, optimal transport and functional inequalities  in dissipative quantum systems,” <i>Journal of Statistical Physics</i>, vol. 178, no. 2. Springer Nature, pp. 319–378, 2020.","ista":"Carlen EA, Maas J. 2020. Non-commutative calculus, optimal transport and functional inequalities  in dissipative quantum systems. Journal of Statistical Physics. 178(2), 319–378.","ama":"Carlen EA, Maas J. Non-commutative calculus, optimal transport and functional inequalities  in dissipative quantum systems. <i>Journal of Statistical Physics</i>. 2020;178(2):319-378. doi:<a href=\"https://doi.org/10.1007/s10955-019-02434-w\">10.1007/s10955-019-02434-w</a>","chicago":"Carlen, Eric A., and Jan Maas. “Non-Commutative Calculus, Optimal Transport and Functional Inequalities  in Dissipative Quantum Systems.” <i>Journal of Statistical Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s10955-019-02434-w\">https://doi.org/10.1007/s10955-019-02434-w</a>."},"scopus_import":"1","abstract":[{"lang":"eng","text":"We study dynamical optimal transport metrics between density matricesassociated to symmetric Dirichlet forms on finite-dimensional C∗-algebras.  Our settingcovers  arbitrary  skew-derivations  and  it  provides  a  unified  framework  that  simultaneously  generalizes  recently  constructed  transport  metrics  for  Markov  chains,  Lindblad  equations,  and  the  Fermi  Ornstein–Uhlenbeck  semigroup.   We  develop  a  non-nommutative differential calculus that allows us to obtain non-commutative Ricci curvature  bounds,  logarithmic  Sobolev  inequalities,  transport-entropy  inequalities,  andspectral gap estimates."}],"arxiv":1,"file_date_updated":"2020-07-14T12:47:28Z","type":"journal_article","_id":"6358","quality_controlled":"1"},{"volume":25,"day":"16","status":"public","date_created":"2019-04-30T07:40:17Z","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["510"],"publication":"Electronic Journal of Probability","doi":"10.1214/20-EJP479","oa_version":"Published Version","isi":1,"article_number":"82","date_published":"2020-07-16T00:00:00Z","intvolume":"        25","month":"07","oa":1,"date_updated":"2023-10-16T09:22:50Z","external_id":{"isi":["000550150700001"],"arxiv":["1812.04583"]},"year":"2020","scopus_import":"1","arxiv":1,"abstract":[{"lang":"eng","text":"The strong rate of convergence of the Euler-Maruyama scheme for nondegenerate SDEs with irregular drift coefficients is considered. In the case of α-Hölder drift in the recent literature the rate α/2 was proved in many related situations. By exploiting the regularising effect of the noise more efficiently, we show that the rate is in fact arbitrarily close to 1/2 for all α>0. The result extends to Dini continuous coefficients, while in d=1 also to all bounded measurable coefficients."}],"type":"journal_article","file_date_updated":"2020-09-21T13:15:02Z","publication_identifier":{"eissn":["1083-6489"]},"citation":{"apa":"Dareiotis, K., &#38; Gerencser, M. (2020). On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/20-EJP479\">https://doi.org/10.1214/20-EJP479</a>","mla":"Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the Noise for the Euler-Maruyama Scheme with Irregular Drift.” <i>Electronic Journal of Probability</i>, vol. 25, 82, Institute of Mathematical Statistics, 2020, doi:<a href=\"https://doi.org/10.1214/20-EJP479\">10.1214/20-EJP479</a>.","ista":"Dareiotis K, Gerencser M. 2020. On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. Electronic Journal of Probability. 25, 82.","short":"K. Dareiotis, M. Gerencser, Electronic Journal of Probability 25 (2020).","ieee":"K. Dareiotis and M. Gerencser, “On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift,” <i>Electronic Journal of Probability</i>, vol. 25. Institute of Mathematical Statistics, 2020.","ama":"Dareiotis K, Gerencser M. On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift. <i>Electronic Journal of Probability</i>. 2020;25. doi:<a href=\"https://doi.org/10.1214/20-EJP479\">10.1214/20-EJP479</a>","chicago":"Dareiotis, Konstantinos, and Mate Gerencser. “On the Regularisation of the Noise for the Euler-Maruyama Scheme with Irregular Drift.” <i>Electronic Journal of Probability</i>. Institute of Mathematical Statistics, 2020. <a href=\"https://doi.org/10.1214/20-EJP479\">https://doi.org/10.1214/20-EJP479</a>."},"quality_controlled":"1","_id":"6359","publication_status":"published","publisher":"Institute of Mathematical Statistics","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Dareiotis","first_name":"Konstantinos","full_name":"Dareiotis, Konstantinos"},{"first_name":"Mate","id":"44ECEDF2-F248-11E8-B48F-1D18A9856A87","last_name":"Gerencser","full_name":"Gerencser, Mate"}],"title":"On the regularisation of the noise for the Euler-Maruyama scheme with irregular drift","file":[{"access_level":"open_access","relation":"main_file","checksum":"8e7c42e72596f6889d786e8e8b89994f","content_type":"application/pdf","file_id":"8549","file_size":273042,"creator":"dernst","date_updated":"2020-09-21T13:15:02Z","date_created":"2020-09-21T13:15:02Z","success":1,"file_name":"2020_EJournProbab_Dareiotis.pdf"}],"department":[{"_id":"JaMa"}],"article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}]},{"project":[{"name":"Random matrices, universality and disordered quantum systems","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","call_identifier":"FP7"},{"grant_number":"665385","call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"publication_status":"published","_id":"6488","quality_controlled":"1","citation":{"mla":"Cipolloni, Giorgio, and László Erdös. “Fluctuations for Differences of Linear Eigenvalue Statistics for Sample Covariance Matrices.” <i>Random Matrices: Theory and Application</i>, vol. 9, no. 3, 2050006, World Scientific Publishing, 2020, doi:<a href=\"https://doi.org/10.1142/S2010326320500069\">10.1142/S2010326320500069</a>.","apa":"Cipolloni, G., &#38; Erdös, L. (2020). Fluctuations for differences of linear eigenvalue statistics for sample covariance matrices. <i>Random Matrices: Theory and Application</i>. World Scientific Publishing. <a href=\"https://doi.org/10.1142/S2010326320500069\">https://doi.org/10.1142/S2010326320500069</a>","chicago":"Cipolloni, Giorgio, and László Erdös. “Fluctuations for Differences of Linear Eigenvalue Statistics for Sample Covariance Matrices.” <i>Random Matrices: Theory and Application</i>. World Scientific Publishing, 2020. <a href=\"https://doi.org/10.1142/S2010326320500069\">https://doi.org/10.1142/S2010326320500069</a>.","ista":"Cipolloni G, Erdös L. 2020. Fluctuations for differences of linear eigenvalue statistics for sample covariance matrices. Random Matrices: Theory and Application. 9(3), 2050006.","ieee":"G. Cipolloni and L. Erdös, “Fluctuations for differences of linear eigenvalue statistics for sample covariance matrices,” <i>Random Matrices: Theory and Application</i>, vol. 9, no. 3. World Scientific Publishing, 2020.","short":"G. Cipolloni, L. Erdös, Random Matrices: Theory and Application 9 (2020).","ama":"Cipolloni G, Erdös L. Fluctuations for differences of linear eigenvalue statistics for sample covariance matrices. <i>Random Matrices: Theory and Application</i>. 2020;9(3). doi:<a href=\"https://doi.org/10.1142/S2010326320500069\">10.1142/S2010326320500069</a>"},"publication_identifier":{"eissn":["20103271"],"issn":["20103263"]},"scopus_import":"1","arxiv":1,"abstract":[{"lang":"eng","text":"We prove a central limit theorem for the difference of linear eigenvalue statistics of a sample covariance matrix W˜ and its minor W. We find that the fluctuation of this difference is much smaller than those of the individual linear statistics, as a consequence of the strong correlation between the eigenvalues of W˜ and W. Our result identifies the fluctuation of the spatial derivative of the approximate Gaussian field in the recent paper by Dumitru and Paquette. Unlike in a similar result for Wigner matrices, for sample covariance matrices, the fluctuation may entirely vanish."}],"type":"journal_article","language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"No","department":[{"_id":"LaEr"}],"author":[{"id":"42198EFA-F248-11E8-B48F-1D18A9856A87","first_name":"Giorgio","last_name":"Cipolloni","orcid":"0000-0002-4901-7992","full_name":"Cipolloni, Giorgio"},{"first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","last_name":"Erdös","full_name":"Erdös, László"}],"title":"Fluctuations for differences of linear eigenvalue statistics for sample covariance matrices","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"World Scientific Publishing","oa_version":"Preprint","ec_funded":1,"isi":1,"publication":"Random Matrices: Theory and Application","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1806.08751"}],"doi":"10.1142/S2010326320500069","date_created":"2019-05-26T21:59:14Z","day":"01","status":"public","volume":9,"year":"2020","external_id":{"isi":["000547464400001"],"arxiv":["1806.08751"]},"date_updated":"2023-08-28T08:38:48Z","oa":1,"issue":"3","date_published":"2020-07-01T00:00:00Z","month":"07","intvolume":"         9","article_number":"2050006"},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"full_name":"Filakovský, Marek","last_name":"Filakovský","first_name":"Marek","id":"3E8AF77E-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Lukas","last_name":"Vokřínek","full_name":"Vokřínek, Lukas"}],"title":"Are two given maps homotopic? An algorithmic viewpoint","publisher":"Springer Nature","article_type":"original","language":[{"iso":"eng"}],"department":[{"_id":"UlWa"}],"article_processing_charge":"No","quality_controlled":"1","_id":"6563","scopus_import":"1","arxiv":1,"abstract":[{"lang":"eng","text":"This paper presents two algorithms. The first decides the existence of a pointed homotopy between given simplicial maps 𝑓,𝑔:𝑋→𝑌, and the second computes the group [𝛴𝑋,𝑌]∗ of pointed homotopy classes of maps from a suspension; in both cases, the target Y is assumed simply connected. More generally, these algorithms work relative to 𝐴⊆𝑋."}],"type":"journal_article","publication_identifier":{"issn":["16153375"],"eissn":["16153383"]},"citation":{"ama":"Filakovský M, Vokřínek L. Are two given maps homotopic? An algorithmic viewpoint. <i>Foundations of Computational Mathematics</i>. 2020;20:311-330. doi:<a href=\"https://doi.org/10.1007/s10208-019-09419-x\">10.1007/s10208-019-09419-x</a>","ista":"Filakovský M, Vokřínek L. 2020. Are two given maps homotopic? An algorithmic viewpoint. Foundations of Computational Mathematics. 20, 311–330.","short":"M. Filakovský, L. Vokřínek, Foundations of Computational Mathematics 20 (2020) 311–330.","ieee":"M. Filakovský and L. Vokřínek, “Are two given maps homotopic? An algorithmic viewpoint,” <i>Foundations of Computational Mathematics</i>, vol. 20. Springer Nature, pp. 311–330, 2020.","chicago":"Filakovský, Marek, and Lukas Vokřínek. “Are Two given Maps Homotopic? An Algorithmic Viewpoint.” <i>Foundations of Computational Mathematics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s10208-019-09419-x\">https://doi.org/10.1007/s10208-019-09419-x</a>.","apa":"Filakovský, M., &#38; Vokřínek, L. (2020). Are two given maps homotopic? An algorithmic viewpoint. <i>Foundations of Computational Mathematics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10208-019-09419-x\">https://doi.org/10.1007/s10208-019-09419-x</a>","mla":"Filakovský, Marek, and Lukas Vokřínek. “Are Two given Maps Homotopic? An Algorithmic Viewpoint.” <i>Foundations of Computational Mathematics</i>, vol. 20, Springer Nature, 2020, pp. 311–30, doi:<a href=\"https://doi.org/10.1007/s10208-019-09419-x\">10.1007/s10208-019-09419-x</a>."},"publication_status":"published","project":[{"name":"Algorithms for Embeddings and Homotopy Theory","_id":"26611F5C-B435-11E9-9278-68D0E5697425","grant_number":"P31312","call_identifier":"FWF"}],"oa":1,"date_updated":"2023-08-17T13:50:44Z","date_published":"2020-04-01T00:00:00Z","intvolume":"        20","month":"04","year":"2020","page":"311-330","external_id":{"arxiv":["1312.2337"],"isi":["000522437400004"]},"status":"public","day":"01","date_created":"2019-06-16T21:59:14Z","volume":20,"oa_version":"Preprint","isi":1,"publication":"Foundations of Computational Mathematics","main_file_link":[{"url":"https://arxiv.org/abs/1312.2337","open_access":"1"}],"doi":"10.1007/s10208-019-09419-x"},{"day":"01","status":"public","date_created":"2019-06-27T20:09:33Z","ddc":["000"],"volume":84,"isi":1,"oa_version":"Submitted Version","ec_funded":1,"doi":"10.1007/s11075-019-00758-y","publication":"Numerical Algorithms","oa":1,"date_updated":"2023-08-17T13:51:18Z","acknowledgement":"The research of this author is supported by the ERC grant at the IST.","intvolume":"        84","month":"05","date_published":"2020-05-01T00:00:00Z","year":"2020","page":"365-388","external_id":{"isi":["000528979000015"]},"quality_controlled":"1","_id":"6593","type":"journal_article","file_date_updated":"2020-07-14T12:47:34Z","abstract":[{"lang":"eng","text":"We consider the monotone variational inequality problem in a Hilbert space and describe a projection-type method with inertial terms under the following properties: (a) The method generates a strongly convergent iteration sequence; (b) The method requires, at each iteration, only one projection onto the feasible set and two evaluations of the operator; (c) The method is designed for variational inequality for which the underline operator is monotone and uniformly continuous; (d) The method includes an inertial term. The latter is also shown to speed up the convergence in our numerical results. A comparison with some related methods is given and indicates that the new method is promising."}],"scopus_import":"1","publication_identifier":{"issn":["1017-1398"],"eissn":["1572-9265"]},"citation":{"apa":"Shehu, Y., Li, X.-H., &#38; Dong, Q.-L. (2020). An efficient projection-type method for monotone variational inequalities in Hilbert spaces. <i>Numerical Algorithms</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s11075-019-00758-y\">https://doi.org/10.1007/s11075-019-00758-y</a>","mla":"Shehu, Yekini, et al. “An Efficient Projection-Type Method for Monotone Variational Inequalities in Hilbert Spaces.” <i>Numerical Algorithms</i>, vol. 84, Springer Nature, 2020, pp. 365–88, doi:<a href=\"https://doi.org/10.1007/s11075-019-00758-y\">10.1007/s11075-019-00758-y</a>.","ama":"Shehu Y, Li X-H, Dong Q-L. An efficient projection-type method for monotone variational inequalities in Hilbert spaces. <i>Numerical Algorithms</i>. 2020;84:365-388. doi:<a href=\"https://doi.org/10.1007/s11075-019-00758-y\">10.1007/s11075-019-00758-y</a>","ista":"Shehu Y, Li X-H, Dong Q-L. 2020. An efficient projection-type method for monotone variational inequalities in Hilbert spaces. Numerical Algorithms. 84, 365–388.","ieee":"Y. Shehu, X.-H. Li, and Q.-L. Dong, “An efficient projection-type method for monotone variational inequalities in Hilbert spaces,” <i>Numerical Algorithms</i>, vol. 84. Springer Nature, pp. 365–388, 2020.","short":"Y. Shehu, X.-H. Li, Q.-L. Dong, Numerical Algorithms 84 (2020) 365–388.","chicago":"Shehu, Yekini, Xiao-Huan Li, and Qiao-Li Dong. “An Efficient Projection-Type Method for Monotone Variational Inequalities in Hilbert Spaces.” <i>Numerical Algorithms</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1007/s11075-019-00758-y\">https://doi.org/10.1007/s11075-019-00758-y</a>."},"publication_status":"published","project":[{"name":"Discrete Optimization in Computer Vision: Theory and Practice","_id":"25FBA906-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"616160"}],"file":[{"creator":"kschuh","file_size":359654,"content_type":"application/pdf","file_id":"6927","checksum":"bb1a1eb3ebb2df380863d0db594673ba","access_level":"open_access","relation":"main_file","file_name":"ExtragradientMethodPaper.pdf","date_updated":"2020-07-14T12:47:34Z","date_created":"2019-10-01T13:14:10Z"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"orcid":"0000-0001-9224-7139","last_name":"Shehu","first_name":"Yekini","id":"3FC7CB58-F248-11E8-B48F-1D18A9856A87","full_name":"Shehu, Yekini"},{"last_name":"Li","first_name":"Xiao-Huan","full_name":"Li, Xiao-Huan"},{"first_name":"Qiao-Li","last_name":"Dong","full_name":"Dong, Qiao-Li"}],"title":"An efficient projection-type method for monotone variational inequalities in Hilbert spaces","publisher":"Springer Nature","has_accepted_license":"1","article_type":"original","language":[{"iso":"eng"}],"department":[{"_id":"VlKo"}],"article_processing_charge":"No"},{"_id":"14326","date_created":"2023-09-13T12:03:46Z","status":"public","quality_controlled":"1","volume":33,"publication_identifier":{"isbn":["9781713829546"]},"citation":{"apa":"Locatello, F., Weissenborn, D., Unterthiner, T., Mahendran, A., Heigold, G., Uszkoreit, J., … Kipf, T. (2020). Object-centric learning with slot attention. In <i>Advances in Neural Information Processing Systems</i> (Vol. 33, pp. 11525–11538). Virtual: Curran Associates.","mla":"Locatello, Francesco, et al. “Object-Centric Learning with Slot Attention.” <i>Advances in Neural Information Processing Systems</i>, vol. 33, Curran Associates, 2020, pp. 11525–38.","ama":"Locatello F, Weissenborn D, Unterthiner T, et al. Object-centric learning with slot attention. In: <i>Advances in Neural Information Processing Systems</i>. Vol 33. Curran Associates; 2020:11525-11538.","short":"F. Locatello, D. Weissenborn, T. Unterthiner, A. Mahendran, G. Heigold, J. Uszkoreit, A. Dosovitskiy, T. Kipf, in:, Advances in Neural Information Processing Systems, Curran Associates, 2020, pp. 11525–11538.","ieee":"F. Locatello <i>et al.</i>, “Object-centric learning with slot attention,” in <i>Advances in Neural Information Processing Systems</i>, Virtual, 2020, vol. 33, pp. 11525–11538.","ista":"Locatello F, Weissenborn D, Unterthiner T, Mahendran A, Heigold G, Uszkoreit J, Dosovitskiy A, Kipf T. 2020. Object-centric learning with slot attention. Advances in Neural Information Processing Systems. NeurIPS: Neural Information Processing Systems vol. 33, 11525–11538.","chicago":"Locatello, Francesco, Dirk Weissenborn, Thomas Unterthiner, Aravindh Mahendran, Georg Heigold, Jakob Uszkoreit, Alexey Dosovitskiy, and Thomas Kipf. “Object-Centric Learning with Slot Attention.” In <i>Advances in Neural Information Processing Systems</i>, 33:11525–38. Curran Associates, 2020."},"extern":"1","arxiv":1,"abstract":[{"lang":"eng","text":"Learning object-centric representations of complex scenes is a promising step towards enabling efficient abstract reasoning from low-level perceptual features. Yet, most deep learning approaches learn distributed representations that do not capture the compositional properties of natural scenes. In this paper, we present the Slot Attention module, an architectural component that interfaces with perceptual representations such as the output of a convolutional neural network and produces a set of task-dependent abstract representations which we call slots. These slots are exchangeable and can bind to any object in the input by specializing through a competitive procedure over multiple rounds of attention. We empirically demonstrate that Slot Attention can extract object-centric representations that enable generalization to unseen compositions when trained on unsupervised object discovery and supervised property prediction tasks.\r\n\r\n"}],"type":"conference","oa_version":"Preprint","publication":"Advances in Neural Information Processing Systems","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2006.15055","open_access":"1"}],"publication_status":"published","date_updated":"2023-09-13T12:19:19Z","title":"Object-centric learning with slot attention","author":[{"full_name":"Locatello, Francesco","last_name":"Locatello","orcid":"0000-0002-4850-0683","first_name":"Francesco","id":"26cfd52f-2483-11ee-8040-88983bcc06d4"},{"last_name":"Weissenborn","first_name":"Dirk","full_name":"Weissenborn, Dirk"},{"full_name":"Unterthiner, Thomas","first_name":"Thomas","last_name":"Unterthiner"},{"last_name":"Mahendran","first_name":"Aravindh","full_name":"Mahendran, Aravindh"},{"full_name":"Heigold, Georg","first_name":"Georg","last_name":"Heigold"},{"first_name":"Jakob","last_name":"Uszkoreit","full_name":"Uszkoreit, Jakob"},{"full_name":"Dosovitskiy, Alexey","first_name":"Alexey","last_name":"Dosovitskiy"},{"last_name":"Kipf","first_name":"Thomas","full_name":"Kipf, Thomas"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"date_published":"2020-01-01T00:00:00Z","intvolume":"        33","publisher":"Curran Associates","language":[{"iso":"eng"}],"year":"2020","page":"11525-11538","external_id":{"arxiv":["2006.15055"]},"article_processing_charge":"No","department":[{"_id":"FrLo"}],"conference":{"end_date":"2020-12-12","start_date":"2020-12-06","name":"NeurIPS: Neural Information Processing Systems","location":"Virtual"}},{"date_updated":"2024-02-21T12:44:48Z","file":[{"success":1,"file_name":"3Dprint-files_download_v2.zip","date_updated":"2023-11-22T14:58:44Z","date_created":"2023-11-22T14:58:44Z","content_type":"application/zip","file_id":"14593","file_size":49297,"creator":"fschur","relation":"main_file","checksum":"0108616e2a59e51879ea51299a29b091","access_level":"open_access"},{"content_type":"text/plain","file_id":"14637","creator":"cchlebak","file_size":641,"access_level":"open_access","checksum":"4c66ddedee4d01c1c4a7978208350cfc","relation":"main_file","success":1,"file_name":"readme.txt","date_created":"2023-12-01T10:39:59Z","date_updated":"2023-12-01T10:39:59Z"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy","author":[{"full_name":"Schur, Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian KM","orcid":"0000-0003-4790-8078","last_name":"Schur"}],"oa":1,"month":"12","has_accepted_license":"1","date_published":"2020-12-01T00:00:00Z","publisher":"Institute of Science and Technology Austria","year":"2020","article_processing_charge":"No","department":[{"_id":"FlSc"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","tmp":{"short":"CC BY-NC-SA (4.0)","image":"/images/cc_by_nc_sa.png","name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"_id":"14592","date_created":"2023-11-22T15:00:57Z","ddc":["570"],"status":"public","day":"01","citation":{"mla":"Schur, Florian KM. <i>STL-Files for 3D-Printed Grid Holders Described in  Fäßler F, Zens B, et Al.; 3D Printed Cell Culture Grid Holders for Improved Cellular Specimen Preparation in Cryo-Electron Microscopy</i>. Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14592\">10.15479/AT:ISTA:14592</a>.","apa":"Schur, F. K. (2020). STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:14592\">https://doi.org/10.15479/AT:ISTA:14592</a>","chicago":"Schur, Florian KM. “STL-Files for 3D-Printed Grid Holders Described in  Fäßler F, Zens B, et Al.; 3D Printed Cell Culture Grid Holders for Improved Cellular Specimen Preparation in Cryo-Electron Microscopy.” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:14592\">https://doi.org/10.15479/AT:ISTA:14592</a>.","ieee":"F. K. Schur, “STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy.” Institute of Science and Technology Austria, 2020.","short":"F.K. Schur, (2020).","ista":"Schur FK. 2020. STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:14592\">10.15479/AT:ISTA:14592</a>.","ama":"Schur FK. STL-files for 3D-printed grid holders described in  Fäßler F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen preparation in cryo-electron microscopy. 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:14592\">10.15479/AT:ISTA:14592</a>"},"file_date_updated":"2023-12-01T10:39:59Z","type":"research_data","abstract":[{"text":"Cryo-electron microscopy (cryo-EM) of cellular specimens provides insights into biological processes and structures within a native context. However, a major challenge still lies in the efficient and reproducible preparation of adherent cells for subsequent cryo-EM analysis. This is due to the sensitivity of many cellular specimens to the varying seeding and culturing conditions required for EM experiments, the often limited amount of cellular material and also the fragility of EM grids and their substrate. Here, we present low-cost and reusable 3D printed grid holders, designed to improve specimen preparation when culturing challenging cellular samples directly on grids. The described grid holders increase cell culture reproducibility and throughput, and reduce the resources required for cell culturing. We show that grid holders can be integrated into various cryo-EM workflows, including micro-patterning approaches to control cell seeding on grids, and for generating samples for cryo-focused ion beam milling and cryo-electron tomography experiments. Their adaptable design allows for the generation of specialized grid holders customized to a large variety of applications.","lang":"eng"}],"related_material":{"record":[{"relation":"research_data","status":"public","id":"8586"}]},"contributor":[{"last_name":"Fäßler","orcid":"0000-0001-7149-769X","first_name":"Florian","id":"404F5528-F248-11E8-B48F-1D18A9856A87","contributor_type":"researcher"},{"last_name":"Zens","id":"45FD126C-F248-11E8-B48F-1D18A9856A87","first_name":"Bettina","contributor_type":"researcher"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert","last_name":"Hauschild","contributor_type":"researcher"},{"contributor_type":"researcher","first_name":"Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","last_name":"Schur","orcid":"0000-0003-4790-8078"}],"oa_version":"Published Version","project":[{"grant_number":"P33367","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","name":"Structure and isoform diversity of the Arp2/3 complex"}],"doi":"10.15479/AT:ISTA:14592"},{"date_published":"2020-09-01T00:00:00Z","month":"09","intvolume":"        25","keyword":["General Mathematics"],"date_updated":"2023-12-18T10:46:09Z","oa":1,"external_id":{"arxiv":["1804.07752"]},"page":"1421-1539","year":"2020","volume":25,"date_created":"2023-12-18T10:37:43Z","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["510"],"status":"public","day":"01","publication":"Documenta Mathematica","doi":"10.4171/dm/780","related_material":{"record":[{"status":"public","relation":"earlier_version","id":"6183"}]},"oa_version":"Published Version","has_accepted_license":"1","publisher":"EMS Press","author":[{"full_name":"Alt, Johannes","last_name":"Alt","id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes"},{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","last_name":"Erdös","orcid":"0000-0001-5366-9603","full_name":"Erdös, László"},{"full_name":"Krüger, Torben H","last_name":"Krüger","orcid":"0000-0002-4821-3297","first_name":"Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"The Dyson equation with linear self-energy: Spectral bands, edges and cusps","file":[{"success":1,"file_name":"2020_DocumentaMathematica_Alt.pdf","date_created":"2023-12-18T10:42:32Z","date_updated":"2023-12-18T10:42:32Z","file_id":"14695","content_type":"application/pdf","file_size":1374708,"creator":"dernst","access_level":"open_access","relation":"main_file","checksum":"12aacc1d63b852ff9a51c1f6b218d4a6"}],"article_processing_charge":"Yes","department":[{"_id":"LaEr"}],"language":[{"iso":"eng"}],"article_type":"original","publication_identifier":{"eissn":["1431-0643"],"issn":["1431-0635"]},"citation":{"mla":"Alt, Johannes, et al. “The Dyson Equation with Linear Self-Energy: Spectral Bands, Edges and Cusps.” <i>Documenta Mathematica</i>, vol. 25, EMS Press, 2020, pp. 1421–539, doi:<a href=\"https://doi.org/10.4171/dm/780\">10.4171/dm/780</a>.","apa":"Alt, J., Erdös, L., &#38; Krüger, T. H. (2020). The Dyson equation with linear self-energy: Spectral bands, edges and cusps. <i>Documenta Mathematica</i>. EMS Press. <a href=\"https://doi.org/10.4171/dm/780\">https://doi.org/10.4171/dm/780</a>","chicago":"Alt, Johannes, László Erdös, and Torben H Krüger. “The Dyson Equation with Linear Self-Energy: Spectral Bands, Edges and Cusps.” <i>Documenta Mathematica</i>. EMS Press, 2020. <a href=\"https://doi.org/10.4171/dm/780\">https://doi.org/10.4171/dm/780</a>.","ama":"Alt J, Erdös L, Krüger TH. The Dyson equation with linear self-energy: Spectral bands, edges and cusps. <i>Documenta Mathematica</i>. 2020;25:1421-1539. doi:<a href=\"https://doi.org/10.4171/dm/780\">10.4171/dm/780</a>","ista":"Alt J, Erdös L, Krüger TH. 2020. The Dyson equation with linear self-energy: Spectral bands, edges and cusps. Documenta Mathematica. 25, 1421–1539.","short":"J. Alt, L. Erdös, T.H. Krüger, Documenta Mathematica 25 (2020) 1421–1539.","ieee":"J. Alt, L. Erdös, and T. H. Krüger, “The Dyson equation with linear self-energy: Spectral bands, edges and cusps,” <i>Documenta Mathematica</i>, vol. 25. EMS Press, pp. 1421–1539, 2020."},"abstract":[{"text":"We study the unique solution m of the Dyson equation \\( -m(z)^{-1} = z\\1 - a + S[m(z)] \\) on a von Neumann algebra A with the constraint Imm≥0. Here, z lies in the complex upper half-plane, a is a self-adjoint element of A and S is a positivity-preserving linear operator on A. We show that m is the Stieltjes transform of a compactly supported A-valued measure on R. Under suitable assumptions, we establish that this measure has a uniformly 1/3-Hölder continuous density with respect to the Lebesgue measure, which is supported on finitely many intervals, called bands. In fact, the density is analytic inside the bands with a square-root growth at the edges and internal cubic root cusps whenever the gap between two bands vanishes. The shape of these singularities is universal and no other singularity may occur. We give a precise asymptotic description of m near the singular points. These asymptotics generalize the analysis at the regular edges given in the companion paper on the Tracy-Widom universality for the edge eigenvalue statistics for correlated random matrices [the first author et al., Ann. Probab. 48, No. 2, 963--1001 (2020; Zbl 1434.60017)] and they play a key role in the proof of the Pearcey universality at the cusp for Wigner-type matrices [G. Cipolloni et al., Pure Appl. Anal. 1, No. 4, 615--707 (2019; Zbl 07142203); the second author et al., Commun. Math. Phys. 378, No. 2, 1203--1278 (2020; Zbl 07236118)]. We also extend the finite dimensional band mass formula from [the first author et al., loc. cit.] to the von Neumann algebra setting by showing that the spectral mass of the bands is topologically rigid under deformations and we conclude that these masses are quantized in some important cases.","lang":"eng"}],"arxiv":1,"type":"journal_article","file_date_updated":"2023-12-18T10:42:32Z","_id":"14694","quality_controlled":"1","publication_status":"published"},{"department":[{"_id":"RoSe"}],"article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}],"publisher":"Mathematical Sciences Publishers","title":" The local density approximation in density functional theory","author":[{"full_name":"Lewin, Mathieu","last_name":"Lewin","first_name":"Mathieu"},{"last_name":"Lieb","first_name":"Elliott H.","full_name":"Lieb, Elliott H."},{"full_name":"Seiringer, Robert","orcid":"0000-0002-6781-0521","last_name":"Seiringer","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","arxiv":1,"abstract":[{"text":"We give the first mathematically rigorous justification of the local density approximation in density functional theory. We provide a quantitative estimate on the difference between the grand-canonical Levy–Lieb energy of a given density (the lowest possible energy of all quantum states having this density) and the integral over the uniform electron gas energy of this density. The error involves gradient terms and justifies the use of the local density approximation in the situation where the density is very flat on sufficiently large regions in space.","lang":"eng"}],"scopus_import":"1","type":"journal_article","publication_identifier":{"issn":["2578-5893"],"eissn":["2578-5885"]},"citation":{"ama":"Lewin M, Lieb EH, Seiringer R.  The local density approximation in density functional theory. <i>Pure and Applied Analysis</i>. 2020;2(1):35-73. doi:<a href=\"https://doi.org/10.2140/paa.2020.2.35\">10.2140/paa.2020.2.35</a>","ieee":"M. Lewin, E. H. Lieb, and R. Seiringer, “ The local density approximation in density functional theory,” <i>Pure and Applied Analysis</i>, vol. 2, no. 1. Mathematical Sciences Publishers, pp. 35–73, 2020.","ista":"Lewin M, Lieb EH, Seiringer R. 2020.  The local density approximation in density functional theory. Pure and Applied Analysis. 2(1), 35–73.","short":"M. Lewin, E.H. Lieb, R. Seiringer, Pure and Applied Analysis 2 (2020) 35–73.","chicago":"Lewin, Mathieu, Elliott H. Lieb, and Robert Seiringer. “ The Local Density Approximation in Density Functional Theory.” <i>Pure and Applied Analysis</i>. Mathematical Sciences Publishers, 2020. <a href=\"https://doi.org/10.2140/paa.2020.2.35\">https://doi.org/10.2140/paa.2020.2.35</a>.","apa":"Lewin, M., Lieb, E. H., &#38; Seiringer, R. (2020).  The local density approximation in density functional theory. <i>Pure and Applied Analysis</i>. Mathematical Sciences Publishers. <a href=\"https://doi.org/10.2140/paa.2020.2.35\">https://doi.org/10.2140/paa.2020.2.35</a>","mla":"Lewin, Mathieu, et al. “ The Local Density Approximation in Density Functional Theory.” <i>Pure and Applied Analysis</i>, vol. 2, no. 1, Mathematical Sciences Publishers, 2020, pp. 35–73, doi:<a href=\"https://doi.org/10.2140/paa.2020.2.35\">10.2140/paa.2020.2.35</a>."},"quality_controlled":"1","_id":"14891","external_id":{"arxiv":["1903.04046"]},"page":"35-73","year":"2020","date_published":"2020-01-01T00:00:00Z","month":"01","intvolume":"         2","oa":1,"issue":"1","date_updated":"2024-01-29T09:01:12Z","publication":"Pure and Applied Analysis","doi":"10.2140/paa.2020.2.35","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.1903.04046","open_access":"1"}],"oa_version":"Preprint","volume":2,"status":"public","day":"01","date_created":"2024-01-28T23:01:44Z"},{"department":[{"_id":"MaLo"}],"article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}],"publisher":"Elsevier","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Molecular recognition at septin interfaces: The switches hold the key","author":[{"full_name":"Rosa, Higor Vinícius Dias","first_name":"Higor Vinícius Dias","last_name":"Rosa"},{"full_name":"Leonardo, Diego Antonio","last_name":"Leonardo","first_name":"Diego Antonio"},{"full_name":"Brognara, Gabriel","first_name":"Gabriel","id":"D96FFDA0-A884-11E9-9968-DC26E6697425","last_name":"Brognara"},{"last_name":"Brandão-Neto","first_name":"José","full_name":"Brandão-Neto, José"},{"last_name":"D'Muniz Pereira","first_name":"Humberto","full_name":"D'Muniz Pereira, Humberto"},{"first_name":"Ana Paula Ulian","last_name":"Araújo","full_name":"Araújo, Ana Paula Ulian"},{"last_name":"Garratt","first_name":"Richard Charles","full_name":"Garratt, Richard Charles"}],"publication_status":"published","abstract":[{"text":"The assembly of a septin filament requires that homologous monomers must distinguish between one another in establishing appropriate interfaces with their neighbors. To understand this phenomenon at the molecular level, we present the first four crystal structures of heterodimeric septin complexes. We describe in detail the two distinct types of G-interface present within the octameric particles, which must polymerize to form filaments. These are formed between SEPT2 and SEPT6 and between SEPT7 and SEPT3, and their description permits an understanding of the structural basis for the selectivity necessary for correct filament assembly. By replacing SEPT6 by SEPT8 or SEPT11, it is possible to rationalize Kinoshita's postulate, which predicts the exchangeability of septins from within a subgroup. Switches I and II, which in classical small GTPases provide a mechanism for nucleotide-dependent conformational change, have been repurposed in septins to play a fundamental role in molecular recognition. Specifically, it is switch I which holds the key to discriminating between the two different G-interfaces. Moreover, residues which are characteristic for a given subgroup play subtle, but pivotal, roles in guaranteeing that the correct interfaces are formed.","lang":"eng"}],"type":"journal_article","publication_identifier":{"issn":["0022-2836"]},"citation":{"mla":"Rosa, Higor Vinícius Dias, et al. “Molecular Recognition at Septin Interfaces: The Switches Hold the Key.” <i>Journal of Molecular Biology</i>, vol. 432, no. 21, Elsevier, 2020, pp. 5784–801, doi:<a href=\"https://doi.org/10.1016/j.jmb.2020.09.001\">10.1016/j.jmb.2020.09.001</a>.","apa":"Rosa, H. V. D., Leonardo, D. A., Brognara, G., Brandão-Neto, J., D’Muniz Pereira, H., Araújo, A. P. U., &#38; Garratt, R. C. (2020). Molecular recognition at septin interfaces: The switches hold the key. <i>Journal of Molecular Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jmb.2020.09.001\">https://doi.org/10.1016/j.jmb.2020.09.001</a>","chicago":"Rosa, Higor Vinícius Dias, Diego Antonio Leonardo, Gabriel Brognara, José Brandão-Neto, Humberto D’Muniz Pereira, Ana Paula Ulian Araújo, and Richard Charles Garratt. “Molecular Recognition at Septin Interfaces: The Switches Hold the Key.” <i>Journal of Molecular Biology</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.jmb.2020.09.001\">https://doi.org/10.1016/j.jmb.2020.09.001</a>.","ama":"Rosa HVD, Leonardo DA, Brognara G, et al. Molecular recognition at septin interfaces: The switches hold the key. <i>Journal of Molecular Biology</i>. 2020;432(21):5784-5801. doi:<a href=\"https://doi.org/10.1016/j.jmb.2020.09.001\">10.1016/j.jmb.2020.09.001</a>","ieee":"H. V. D. Rosa <i>et al.</i>, “Molecular recognition at septin interfaces: The switches hold the key,” <i>Journal of Molecular Biology</i>, vol. 432, no. 21. Elsevier, pp. 5784–5801, 2020.","short":"H.V.D. Rosa, D.A. Leonardo, G. Brognara, J. Brandão-Neto, H. D’Muniz Pereira, A.P.U. Araújo, R.C. Garratt, Journal of Molecular Biology 432 (2020) 5784–5801.","ista":"Rosa HVD, Leonardo DA, Brognara G, Brandão-Neto J, D’Muniz Pereira H, Araújo APU, Garratt RC. 2020. Molecular recognition at septin interfaces: The switches hold the key. Journal of Molecular Biology. 432(21), 5784–5801."},"quality_controlled":"1","_id":"15036","external_id":{"pmid":["32910969"]},"page":"5784-5801","year":"2020","date_published":"2020-10-02T00:00:00Z","intvolume":"       432","month":"10","oa":1,"issue":"21","keyword":["Molecular Biology","Structural Biology"],"date_updated":"2024-02-28T12:37:54Z","publication":"Journal of Molecular Biology","doi":"10.1016/j.jmb.2020.09.001","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.jmb.2020.09.001"}],"oa_version":"Published Version","volume":432,"pmid":1,"status":"public","day":"02","date_created":"2024-02-28T08:50:34Z"},{"publication_status":"published","publication_identifier":{"issn":["1674-2052"]},"citation":{"apa":"Moulinier-Anzola, J., Schwihla, M., De-Araújo, L., Artner, C., Jörg, L., Konstantinova, N., … Korbei, B. (2020). TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants. <i>Molecular Plant</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.molp.2020.02.012\">https://doi.org/10.1016/j.molp.2020.02.012</a>","mla":"Moulinier-Anzola, Jeanette, et al. “TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants.” <i>Molecular Plant</i>, vol. 13, no. 5, Elsevier, 2020, pp. 717–31, doi:<a href=\"https://doi.org/10.1016/j.molp.2020.02.012\">10.1016/j.molp.2020.02.012</a>.","short":"J. Moulinier-Anzola, M. Schwihla, L. De-Araújo, C. Artner, L. Jörg, N. Konstantinova, C. Luschnig, B. Korbei, Molecular Plant 13 (2020) 717–731.","ieee":"J. Moulinier-Anzola <i>et al.</i>, “TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants,” <i>Molecular Plant</i>, vol. 13, no. 5. Elsevier, pp. 717–731, 2020.","ista":"Moulinier-Anzola J, Schwihla M, De-Araújo L, Artner C, Jörg L, Konstantinova N, Luschnig C, Korbei B. 2020. TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants. Molecular Plant. 13(5), 717–731.","ama":"Moulinier-Anzola J, Schwihla M, De-Araújo L, et al. TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants. <i>Molecular Plant</i>. 2020;13(5):717-731. doi:<a href=\"https://doi.org/10.1016/j.molp.2020.02.012\">10.1016/j.molp.2020.02.012</a>","chicago":"Moulinier-Anzola, Jeanette, Maximilian Schwihla, Lucinda De-Araújo, Christina Artner, Lisa Jörg, Nataliia Konstantinova, Christian Luschnig, and Barbara Korbei. “TOLs Function as Ubiquitin Receptors in the Early Steps of the ESCRT Pathway in Higher Plants.” <i>Molecular Plant</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.molp.2020.02.012\">https://doi.org/10.1016/j.molp.2020.02.012</a>."},"file_date_updated":"2024-02-28T12:39:56Z","type":"journal_article","abstract":[{"text":"Protein abundance and localization at the plasma membrane (PM) shapes plant development and mediates adaptation to changing environmental conditions. It is regulated by ubiquitination, a post-translational modification crucial for the proper sorting of endocytosed PM proteins to the vacuole for subsequent degradation. To understand the significance and the variety of roles played by this reversible modification, the function of ubiquitin receptors, which translate the ubiquitin signature into a cellular response, needs to be elucidated. In this study, we show that TOL (TOM1-like) proteins function in plants as multivalent ubiquitin receptors, governing ubiquitinated cargo delivery to the vacuole via the conserved Endosomal Sorting Complex Required for Transport (ESCRT) pathway. TOL2 and TOL6 interact with components of the ESCRT machinery and bind to K63-linked ubiquitin via two tandemly arranged conserved ubiquitin-binding domains. Mutation of these domains results not only in a loss of ubiquitin binding but also altered localization, abolishing TOL6 ubiquitin receptor activity. Function and localization of TOL6 is itself regulated by ubiquitination, whereby TOL6 ubiquitination potentially modulates degradation of PM-localized cargoes, assisting in the fine-tuning of the delicate interplay between protein recycling and downregulation. Taken together, our findings demonstrate the function and regulation of a ubiquitin receptor that mediates vacuolar degradation of PM proteins in higher plants.","lang":"eng"}],"_id":"15037","quality_controlled":"1","article_processing_charge":"No","department":[{"_id":"EvBe"}],"language":[{"iso":"eng"}],"article_type":"original","has_accepted_license":"1","publisher":"Elsevier","file":[{"date_updated":"2024-02-28T12:39:56Z","date_created":"2024-02-28T12:39:56Z","success":1,"file_name":"2020_MolecularPlant_MoulinierAnzola.pdf","access_level":"open_access","relation":"main_file","checksum":"c538a5008f7827f62d17d40a3bfabe65","file_id":"15038","content_type":"application/pdf","creator":"dernst","file_size":3089212}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Moulinier-Anzola, Jeanette","first_name":"Jeanette","last_name":"Moulinier-Anzola"},{"full_name":"Schwihla, Maximilian","first_name":"Maximilian","last_name":"Schwihla"},{"last_name":"De-Araújo","first_name":"Lucinda","full_name":"De-Araújo, Lucinda"},{"last_name":"Artner","id":"45DF286A-F248-11E8-B48F-1D18A9856A87","first_name":"Christina","full_name":"Artner, Christina"},{"full_name":"Jörg, Lisa","first_name":"Lisa","last_name":"Jörg"},{"full_name":"Konstantinova, Nataliia","last_name":"Konstantinova","first_name":"Nataliia"},{"first_name":"Christian","last_name":"Luschnig","full_name":"Luschnig, Christian"},{"first_name":"Barbara","last_name":"Korbei","full_name":"Korbei, Barbara"}],"title":"TOLs function as ubiquitin receptors in the early steps of the ESCRT pathway in higher plants","doi":"10.1016/j.molp.2020.02.012","publication":"Molecular Plant","oa_version":"Published Version","pmid":1,"volume":13,"ddc":["580"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"date_created":"2024-02-28T08:55:56Z","status":"public","day":"04","page":"717-731","external_id":{"pmid":["32087370"]},"year":"2020","month":"05","intvolume":"        13","date_published":"2020-05-04T00:00:00Z","date_updated":"2024-02-28T12:41:52Z","keyword":["Plant Science","Molecular Biology"],"issue":"5","oa":1},{"language":[{"iso":"eng"}],"article_type":"original","article_processing_charge":"No","department":[{"_id":"KrCh"}],"title":"Reinforcement learning of risk-constrained policies in Markov decision processes","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Brázdil, Tomáš","last_name":"Brázdil","first_name":"Tomáš"},{"full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","first_name":"Krishnendu","last_name":"Chatterjee","orcid":"0000-0002-4561-241X"},{"full_name":"Novotný, Petr","first_name":"Petr","last_name":"Novotný"},{"first_name":"Jiří","last_name":"Vahala","full_name":"Vahala, Jiří"}],"publisher":"Association for the Advancement of Artificial Intelligence","project":[{"_id":"25863FF4-B435-11E9-9278-68D0E5697425","name":"Game Theory","grant_number":"S11407","call_identifier":"FWF"}],"publication_status":"published","_id":"15055","quality_controlled":"1","publication_identifier":{"issn":["2374-3468"]},"citation":{"apa":"Brázdil, T., Chatterjee, K., Novotný, P., &#38; Vahala, J. (2020). Reinforcement learning of risk-constrained policies in Markov decision processes. <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>. New York, NY, United States: Association for the Advancement of Artificial Intelligence. <a href=\"https://doi.org/10.1609/aaai.v34i06.6531\">https://doi.org/10.1609/aaai.v34i06.6531</a>","mla":"Brázdil, Tomáš, et al. “Reinforcement Learning of Risk-Constrained Policies in Markov Decision Processes.” <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>, vol. 34, no. 06, Association for the Advancement of Artificial Intelligence, 2020, pp. 9794–801, doi:<a href=\"https://doi.org/10.1609/aaai.v34i06.6531\">10.1609/aaai.v34i06.6531</a>.","ama":"Brázdil T, Chatterjee K, Novotný P, Vahala J. Reinforcement learning of risk-constrained policies in Markov decision processes. <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>. 2020;34(06):9794-9801. doi:<a href=\"https://doi.org/10.1609/aaai.v34i06.6531\">10.1609/aaai.v34i06.6531</a>","ieee":"T. Brázdil, K. Chatterjee, P. Novotný, and J. Vahala, “Reinforcement learning of risk-constrained policies in Markov decision processes,” <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>, vol. 34, no. 06. Association for the Advancement of Artificial Intelligence, pp. 9794–9801, 2020.","short":"T. Brázdil, K. Chatterjee, P. Novotný, J. Vahala, Proceedings of the 34th AAAI Conference on Artificial Intelligence 34 (2020) 9794–9801.","ista":"Brázdil T, Chatterjee K, Novotný P, Vahala J. 2020. Reinforcement learning of risk-constrained policies in Markov decision processes. Proceedings of the 34th AAAI Conference on Artificial Intelligence. 34(06), 9794–9801.","chicago":"Brázdil, Tomáš, Krishnendu Chatterjee, Petr Novotný, and Jiří Vahala. “Reinforcement Learning of Risk-Constrained Policies in Markov Decision Processes.” <i>Proceedings of the 34th AAAI Conference on Artificial Intelligence</i>. Association for the Advancement of Artificial Intelligence, 2020. <a href=\"https://doi.org/10.1609/aaai.v34i06.6531\">https://doi.org/10.1609/aaai.v34i06.6531</a>."},"type":"journal_article","abstract":[{"text":"<jats:p>Markov decision processes (MDPs) are the defacto framework for sequential decision making in the presence of stochastic uncertainty. A classical optimization criterion for MDPs is to maximize the expected discounted-sum payoff, which ignores low probability catastrophic events with highly negative impact on the system. On the other hand, risk-averse policies require the probability of undesirable events to be below a given threshold, but they do not account for optimization of the expected payoff. We consider MDPs with discounted-sum payoff with failure states which represent catastrophic outcomes. The objective of risk-constrained planning is to maximize the expected discounted-sum payoff among risk-averse policies that ensure the probability to encounter a failure state is below a desired threshold. Our main contribution is an efficient risk-constrained planning algorithm that combines UCT-like search with a predictor learned through interaction with the MDP (in the style of AlphaZero) and with a risk-constrained action selection via linear programming. We demonstrate the effectiveness of our approach with experiments on classical MDPs from the literature, including benchmarks with an order of 106 states.</jats:p>","lang":"eng"}],"arxiv":1,"year":"2020","page":"9794-9801","external_id":{"arxiv":["2002.12086"]},"conference":{"end_date":"2020-02-12","start_date":"2020-02-07","name":"AAAI: Conference on Artificial Intelligence","location":"New York, NY, United States"},"date_updated":"2024-03-04T08:30:16Z","keyword":["General Medicine"],"issue":"06","oa":1,"intvolume":"        34","month":"04","date_published":"2020-04-03T00:00:00Z","acknowledgement":"Krishnendu Chatterjee is supported by the Austrian Science Fund (FWF) NFN Grant No. S11407-N23 (RiSE/SHiNE), and COST Action GAMENET. Tomas Brazdil is supported by the Grant Agency of Masaryk University grant no. MUNI/G/0739/2017 and by the Czech Science Foundation grant No. 18-11193S. Petr Novotny and Jirı Vahala are supported by the Czech Science Foundation grant No. GJ19-15134Y.","oa_version":"Preprint","doi":"10.1609/aaai.v34i06.6531","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2002.12086","open_access":"1"}],"publication":"Proceedings of the 34th AAAI Conference on Artificial Intelligence","date_created":"2024-03-04T08:07:22Z","day":"03","status":"public","volume":34},{"abstract":[{"text":"Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show that VRK-1 increases organismal longevity by activating the cellular energy sensor, AMP-activated protein kinase (AMPK), via direct phosphorylation. We found that overexpression of vrk-1 in the soma of adult C. elegans increased life span and, conversely, inhibition of vrk-1 decreased life span. In addition, vrk-1 was required for longevity conferred by mutations that inhibit C. elegans mitochondrial respiration, which requires AMPK. VRK-1 directly phosphorylated and up-regulated AMPK in both C. elegans and cultured human cells. Thus, our data show that the somatic nuclear kinase, VRK-1, promotes longevity through AMPK activation, and this function appears to be conserved between C. elegans and humans.","lang":"eng"}],"type":"journal_article","file_date_updated":"2024-03-04T09:46:41Z","citation":{"mla":"Park, Sangsoon, et al. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>, vol. 6, no. 27, aaw7824, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>.","apa":"Park, S., Artan, M., Han, S. H., Park, H.-E. H., Jung, Y., Hwang, A. B., … Lee, S.-J. V. (2020). VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>","chicago":"Park, Sangsoon, Murat Artan, Seung Hyun Han, Hae-Eun H. Park, Yoonji Jung, Ara B. Hwang, Won Sik Shin, Kyong-Tai Kim, and Seung-Jae V. Lee. “VRK-1 Extends Life Span by Activation of AMPK via Phosphorylation.” <i>Science Advances</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/sciadv.aaw7824\">https://doi.org/10.1126/sciadv.aaw7824</a>.","ista":"Park S, Artan M, Han SH, Park H-EH, Jung Y, Hwang AB, Shin WS, Kim K-T, Lee S-JV. 2020. VRK-1 extends life span by activation of AMPK via phosphorylation. Science Advances. 6(27), aaw7824.","ieee":"S. Park <i>et al.</i>, “VRK-1 extends life span by activation of AMPK via phosphorylation,” <i>Science Advances</i>, vol. 6, no. 27. American Association for the Advancement of Science, 2020.","short":"S. Park, M. Artan, S.H. Han, H.-E.H. Park, Y. Jung, A.B. Hwang, W.S. Shin, K.-T. Kim, S.-J.V. Lee, Science Advances 6 (2020).","ama":"Park S, Artan M, Han SH, et al. VRK-1 extends life span by activation of AMPK via phosphorylation. <i>Science Advances</i>. 2020;6(27). doi:<a href=\"https://doi.org/10.1126/sciadv.aaw7824\">10.1126/sciadv.aaw7824</a>"},"publication_identifier":{"eissn":["2375-2548"]},"quality_controlled":"1","_id":"15057","publication_status":"published","publisher":"American Association for the Advancement of Science","has_accepted_license":"1","title":"VRK-1 extends life span by activation of AMPK via phosphorylation","author":[{"first_name":"Sangsoon","last_name":"Park","full_name":"Park, Sangsoon"},{"full_name":"Artan, Murat","id":"C407B586-6052-11E9-B3AE-7006E6697425","first_name":"Murat","last_name":"Artan","orcid":"0000-0001-8945-6992"},{"first_name":"Seung Hyun","last_name":"Han","full_name":"Han, Seung Hyun"},{"last_name":"Park","first_name":"Hae-Eun H.","full_name":"Park, Hae-Eun H."},{"full_name":"Jung, Yoonji","last_name":"Jung","first_name":"Yoonji"},{"full_name":"Hwang, Ara B.","first_name":"Ara B.","last_name":"Hwang"},{"full_name":"Shin, Won Sik","first_name":"Won Sik","last_name":"Shin"},{"first_name":"Kyong-Tai","last_name":"Kim","full_name":"Kim, Kyong-Tai"},{"full_name":"Lee, Seung-Jae V.","first_name":"Seung-Jae V.","last_name":"Lee"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"date_created":"2024-03-04T09:46:41Z","date_updated":"2024-03-04T09:46:41Z","success":1,"file_name":"2020_ScienceAdvances_Park.pdf","access_level":"open_access","relation":"main_file","checksum":"a37157cd0de709dce5fe03f4a31cd0b6","file_id":"15058","content_type":"application/pdf","creator":"dernst","file_size":1864415}],"department":[{"_id":"MaDe"}],"article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}],"volume":6,"status":"public","day":"01","tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"},"date_created":"2024-03-04T09:41:57Z","ddc":["570"],"publication":"Science Advances","doi":"10.1126/sciadv.aaw7824","oa_version":"Published Version","article_number":"aaw7824","acknowledgement":"This research was supported by grants NRF-2019R1A3B2067745 and NRF-2017R1A5A1015366 funded by the Korean Government (MSIT) through the National Research Foundation (NRF) of Korea to S.-J.V.L. and by grant Basic Science Research Program (No. 2019R1A2C2009440) funded by the Korean Government (MSIT) through the NRF of Korea to K.-T.K. ","date_published":"2020-07-01T00:00:00Z","intvolume":"         6","month":"07","oa":1,"issue":"27","date_updated":"2024-03-04T09:52:09Z","license":"https://creativecommons.org/licenses/by-nc/4.0/","year":"2020"},{"publication":"Proceedings of the National Academy of Sciences","main_file_link":[{"url":"https://doi.org/10.1073/pnas.191726911","open_access":"1"}],"doi":"10.1073/pnas.1917269117","oa_version":"Published Version","volume":117,"pmid":1,"day":"08","status":"public","date_created":"2024-03-04T10:03:52Z","external_id":{"pmid":["32848067"]},"page":"22101-22112","year":"2020","acknowledgement":"We thank the staff of the macromolecular crystallography (MX) and SAXS beamlines at the European Synchrotron Radiation facility, Diamond, and Swiss Light Source for excellent support, and the Life Sciences Facility of the Institute of Science and Technology Austria for usage of the rheometer. We thank Life Sciences editors for editing assistance. EM data were\r\nrecorded at the EM Facility of the Vienna BioCenter Core Facilities (Austria). Confocal microscopy was carried out at the Advanced Instrument Research Facility, Jawaharlal Nehru University. K.D.-C.’s research was supported by the Initial Training Network MUZIC (ITN-MUZIC) (N°238423), Austrian Science Fund (FWF) Projects I525, I1593, P22276, P19060, and W1221, Laura Bassi Centre of Optimized Structural Studies (N°253275), a Wellcome Trust Collaborative Award (201543/Z/16/Z), COST Action BM1405, Vienna Science and Technology Fund (WWTF) Chemical Biology Project LS17-008, and Christian Doppler Laboratory for High-Content Structural Biology and Biotechnology. K.Z., J.L.A., C.S., E.A.G., and A.S. were supported by the University of Vienna, J.K. by a Wellcome Trust Collaborative Award and by the Centre of Optimized Structural Studies, M.P. by FWF Project I1593, E.d.A.R. ITN-MUZIC, and FWF Projects I525 and I1593, and T.C.M. and L.C. by FWF Project I 2408-B22. E.A.G. acknowledges the PhD program Structure and Interaction of Biological Macromolecules. M.B. acknowledges the University Grant Commission, India, for a senior research fellowship. A.B. acknowledges a JC Bose Fellowship from the Science Engineering Research Council. ","date_published":"2020-09-08T00:00:00Z","intvolume":"       117","month":"09","acknowledged_ssus":[{"_id":"LifeSc"}],"oa":1,"issue":"36","date_updated":"2024-03-04T10:14:44Z","publication_status":"published","abstract":[{"text":"The actin cytoskeleton, a dynamic network of actin filaments and associated F-actin–binding proteins, is fundamentally important in eukaryotes. α-Actinins are major F-actin bundlers that are inhibited by Ca2+ in nonmuscle cells. Here we report the mechanism of Ca2+-mediated regulation of Entamoeba histolytica α-actinin-2 (EhActn2) with features expected for the common ancestor of Entamoeba and higher eukaryotic α-actinins. Crystal structures of Ca2+-free and Ca2+-bound EhActn2 reveal a calmodulin-like domain (CaMD) uniquely inserted within the rod domain. Integrative studies reveal an exceptionally high affinity of the EhActn2 CaMD for Ca2+, binding of which can only be regulated in the presence of physiological concentrations of Mg2+. Ca2+ binding triggers an increase in protein multidomain rigidity, reducing conformational flexibility of F-actin–binding domains via interdomain cross-talk and consequently inhibiting F-actin bundling. In vivo studies uncover that EhActn2 plays an important role in phagocytic cup formation and might constitute a new drug target for amoebic dysentery.","lang":"eng"}],"type":"journal_article","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"citation":{"mla":"Pinotsis, Nikos, et al. “Calcium Modulates the Domain Flexibility and Function of an α-Actinin Similar to the Ancestral α-Actinin.” <i>Proceedings of the National Academy of Sciences</i>, vol. 117, no. 36, Proceedings of the National Academy of Sciences, 2020, pp. 22101–12, doi:<a href=\"https://doi.org/10.1073/pnas.1917269117\">10.1073/pnas.1917269117</a>.","apa":"Pinotsis, N., Zielinska, K., Babuta, M., Arolas, J. L., Kostan, J., Khan, M. B., … Djinovic-Carugo, K. (2020). Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin. <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1917269117\">https://doi.org/10.1073/pnas.1917269117</a>","chicago":"Pinotsis, Nikos, Karolina Zielinska, Mrigya Babuta, Joan L. Arolas, Julius Kostan, Muhammad Bashir Khan, Claudia Schreiner, et al. “Calcium Modulates the Domain Flexibility and Function of an α-Actinin Similar to the Ancestral α-Actinin.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences, 2020. <a href=\"https://doi.org/10.1073/pnas.1917269117\">https://doi.org/10.1073/pnas.1917269117</a>.","ama":"Pinotsis N, Zielinska K, Babuta M, et al. Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin. <i>Proceedings of the National Academy of Sciences</i>. 2020;117(36):22101-22112. doi:<a href=\"https://doi.org/10.1073/pnas.1917269117\">10.1073/pnas.1917269117</a>","short":"N. Pinotsis, K. Zielinska, M. Babuta, J.L. Arolas, J. Kostan, M.B. Khan, C. Schreiner, A.P. Testa Salmazo, L. Ciccarelli, M. Puchinger, E.A. Gkougkoulia, E. de A. Ribeiro, T.C. Marlovits, A. Bhattacharya, K. Djinovic-Carugo, Proceedings of the National Academy of Sciences 117 (2020) 22101–22112.","ista":"Pinotsis N, Zielinska K, Babuta M, Arolas JL, Kostan J, Khan MB, Schreiner C, Testa Salmazo AP, Ciccarelli L, Puchinger M, Gkougkoulia EA, Ribeiro E de A, Marlovits TC, Bhattacharya A, Djinovic-Carugo K. 2020. Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin. Proceedings of the National Academy of Sciences. 117(36), 22101–22112.","ieee":"N. Pinotsis <i>et al.</i>, “Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin,” <i>Proceedings of the National Academy of Sciences</i>, vol. 117, no. 36. Proceedings of the National Academy of Sciences, pp. 22101–22112, 2020."},"quality_controlled":"1","_id":"15061","department":[{"_id":"CaBe"}],"article_processing_charge":"No","article_type":"original","language":[{"iso":"eng"}],"publisher":"Proceedings of the National Academy of Sciences","title":"Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Pinotsis","first_name":"Nikos","full_name":"Pinotsis, Nikos"},{"first_name":"Karolina","last_name":"Zielinska","full_name":"Zielinska, Karolina"},{"full_name":"Babuta, Mrigya","first_name":"Mrigya","last_name":"Babuta"},{"full_name":"Arolas, Joan L.","last_name":"Arolas","first_name":"Joan L."},{"full_name":"Kostan, Julius","last_name":"Kostan","first_name":"Julius"},{"full_name":"Khan, Muhammad Bashir","first_name":"Muhammad Bashir","last_name":"Khan"},{"first_name":"Claudia","last_name":"Schreiner","full_name":"Schreiner, Claudia"},{"full_name":"Testa Salmazo, Anita P","first_name":"Anita P","id":"41F1F098-F248-11E8-B48F-1D18A9856A87","last_name":"Testa Salmazo"},{"full_name":"Ciccarelli, Luciano","first_name":"Luciano","last_name":"Ciccarelli"},{"last_name":"Puchinger","first_name":"Martin","full_name":"Puchinger, Martin"},{"full_name":"Gkougkoulia, Eirini A.","last_name":"Gkougkoulia","first_name":"Eirini A."},{"full_name":"Ribeiro, Euripedes de Almeida","first_name":"Euripedes de Almeida","last_name":"Ribeiro"},{"first_name":"Thomas C.","last_name":"Marlovits","full_name":"Marlovits, Thomas C."},{"last_name":"Bhattacharya","first_name":"Alok","full_name":"Bhattacharya, Alok"},{"full_name":"Djinovic-Carugo, Kristina","last_name":"Djinovic-Carugo","first_name":"Kristina"}]}]
