[{"abstract":[{"text":"Left-right asymmetries can be considered a fundamental organizational principle of the vertebrate central nervous system. The hippocampal CA3-CA1 pyramidal cell synaptic connection shows an input-side dependent asymmetry where the hemispheric location of the presynaptic CA3 neuron determines the synaptic properties. Left-input synapses terminating on apical dendrites in stratum radiatum have a higher density of NMDA receptor subunit GluN2B, a lower density of AMPA receptor subunit GluA1 and smaller areas with less often perforated PSDs. On the other hand, left-input synapses terminating on basal dendrites in stratum oriens have lower GluN2B densities than right-input ones. Apical and basal synapses further employ different signaling pathways involved in LTP. SDS-digested freeze-fracture replica labeling can visualize synaptic membrane proteins with high sensitivity and resolution, and has been used to reveal the asymmetry at the electron microscopic level. However, it requires time-consuming manual demarcation of the synaptic surface for quantitative measurements. To facilitate the analysis of replica labeling, I first developed a software named Darea, which utilizes deep-learning to automatize this demarcation. With Darea I characterized the synaptic distribution of NMDA and AMPA receptors as well as the voltage-gated Ca2+ channels in CA1 stratum radiatum and oriens. Second, I explored the role of GluN2B and its carboxy-terminus in the establishment of input-side dependent hippocampal asymmetry. In conditional knock-out mice lacking GluN2B expression in CA1 and GluN2B-2A swap mice, where GluN2B carboxy-terminus was exchanged to that of GluN2A, no significant asymmetries of GluN2B, GluA1 and PSD area were detected. We further discovered a previously unknown functional asymmetry of GluN2A, which was also lost in the swap mouse. These results demonstrate that GluN2B carboxy-terminus plays a critical role in normal formation of input-side dependent asymmetry.","lang":"eng"}],"alternative_title":["ISTA Thesis"],"article_processing_charge":"No","publication_identifier":{"issn":["2663-337X"]},"file_date_updated":"2022-07-02T22:30:04Z","ddc":["570"],"publication_status":"published","language":[{"iso":"eng"}],"_id":"9562","department":[{"_id":"GradSch"},{"_id":"RySh"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","doi":"10.15479/at:ista:9562","supervisor":[{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi"}],"oa_version":"Published Version","year":"2021","type":"dissertation","status":"public","title":"2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning","author":[{"id":"42E121A4-F248-11E8-B48F-1D18A9856A87","full_name":"Kleindienst, David","last_name":"Kleindienst","first_name":"David"}],"oa":1,"acknowledged_ssus":[{"_id":"EM-Fac"}],"publisher":"Institute of Science and Technology Austria","page":"124","degree_awarded":"PhD","has_accepted_license":"1","month":"06","date_published":"2021-06-01T00:00:00Z","date_created":"2021-06-17T14:10:47Z","related_material":{"record":[{"id":"9756","relation":"part_of_dissertation","status":"public"},{"id":"9437","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"8532"},{"id":"612","relation":"part_of_dissertation","status":"public"}]},"date_updated":"2023-09-11T12:55:53Z","file":[{"checksum":"659df5518db495f679cb1df9e9bd1d94","embargo":"2022-07-01","date_updated":"2022-07-02T22:30:04Z","file_name":"Thesis.pdf","content_type":"application/pdf","access_level":"open_access","file_size":77299142,"creator":"dkleindienst","file_id":"9563","relation":"main_file","date_created":"2021-06-17T14:03:14Z"},{"date_updated":"2022-07-02T22:30:04Z","file_name":"Thesis_source.zip","checksum":"3bcf63a2b19e5b6663be051bea332748","file_size":369804895,"file_id":"9564","creator":"dkleindienst","relation":"source_file","embargo_to":"open_access","date_created":"2021-06-17T14:04:30Z","content_type":"application/zip","access_level":"closed"}],"citation":{"ieee":"D. Kleindienst, “2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning,” Institute of Science and Technology Austria, 2021.","apa":"Kleindienst, D. (2021). <i>2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:9562\">https://doi.org/10.15479/at:ista:9562</a>","short":"D. Kleindienst, 2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning, Institute of Science and Technology Austria, 2021.","chicago":"Kleindienst, David. “2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:9562\">https://doi.org/10.15479/at:ista:9562</a>.","mla":"Kleindienst, David. <i>2B or Not 2B: Hippocampal Asymmetries Mediated by NMDA Receptor Subunit GluN2B C-Terminus and High-Throughput Image Analysis by Deep-Learning</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:9562\">10.15479/at:ista:9562</a>.","ama":"Kleindienst D. 2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:9562\">10.15479/at:ista:9562</a>","ista":"Kleindienst D. 2021. 2B or not 2B: Hippocampal asymmetries mediated by NMDA receptor subunit GluN2B C-terminus and high-throughput image analysis by Deep-Learning. Institute of Science and Technology Austria."},"day":"01"},{"publication_status":"published","ddc":["540"],"_id":"9569","language":[{"iso":"eng"}],"external_id":{"isi":["000665644000048"]},"department":[{"_id":"KiMo"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"lang":"eng","text":"We report the synthesis and characterization of graphene functionalized with iron (Fe3+) oxide (G-Fe3O4) nanohybrids for radio-frequency magnetic hyperthermia application. We adopted the wet chemical procedure, using various contents of Fe3O4 (magnetite) from 0–100% for making two-dimensional graphene–Fe3O4 nanohybrids. The homogeneous dispersal of Fe3O4 nanoparticles decorated on the graphene surface combined with their biocompatibility and high thermal conductivity make them an excellent material for magnetic hyperthermia. The morphological and magnetic properties of the nanohybrids were studied using scanning electron microscopy (SEM) and a vibrating sample magnetometer (VSM), respectively. The smart magnetic platforms were exposed to an alternating current (AC) magnetic field of 633 kHz and of strength 9.1 mT for studying their hyperthermic performance. The localized antitumor effects were investigated with artificial neural network modeling. A neural net time-series model was developed for the assessment of the best nanohybrid composition to serve the purpose with an accuracy close to 100%. Six Nonlinear Autoregressive with External Input (NARX) models were obtained, one for each of the components. The assessment of the accuracy of the predicted results has been done on the basis of Mean Squared Error (MSE). The highest Mean Squared Error value was obtained for the nanohybrid containing 45% magnetite and 55% graphene (F45G55) in the training phase i.e., 0.44703, which is where the model achieved optimal results after 71 epochs. The F45G55 nanohybrid was found to be the best for hyperthermia applications in low dosage with the highest specific absorption rate (SAR) and mean squared error values."}],"publication_identifier":{"eissn":["2046-2069"]},"file_date_updated":"2021-06-23T13:09:34Z","article_processing_charge":"No","acknowledgement":"The research is funded by Higher Education Commission (HEC) Pakistan under start-up research grant program (SRGP) Project no. 2454.","isi":1,"type":"journal_article","year":"2021","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 3.0 Unported (CC BY 3.0)","short":"CC BY (3.0)","legal_code_url":"https://creativecommons.org/licenses/by/3.0/legalcode"},"doi":"10.1039/d1ra03428f","oa_version":"Published Version","issue":"35","publisher":"Royal Society of Chemistry","quality_controlled":"1","page":"21702-21715","intvolume":"        11","publication":"RSC Advances","title":"Heat induction in two-dimensional graphene–Fe3O4 nanohybrids for magnetic hyperthermia applications with artificial neural network modeling","status":"public","oa":1,"author":[{"first_name":"M. S.","last_name":"Dar","full_name":"Dar, M. S."},{"full_name":"Akram, Khush Bakhat","last_name":"Akram","first_name":"Khush Bakhat"},{"last_name":"Sohail","first_name":"Ayesha","full_name":"Sohail, Ayesha"},{"full_name":"Arif, Fatima","last_name":"Arif","first_name":"Fatima"},{"first_name":"Fatemeh","last_name":"Zabihi","full_name":"Zabihi, Fatemeh"},{"first_name":"Shengyuan","last_name":"Yang","full_name":"Yang, Shengyuan"},{"first_name":"Shamsa","last_name":"Munir","full_name":"Munir, Shamsa"},{"first_name":"Meifang","last_name":"Zhu","full_name":"Zhu, Meifang"},{"last_name":"Abid","first_name":"M.","full_name":"Abid, M."},{"orcid":"0000-0002-2111-4846","last_name":"Nauman","first_name":"Muhammad","id":"32c21954-2022-11eb-9d5f-af9f93c24e71","full_name":"Nauman, Muhammad"}],"file":[{"access_level":"open_access","content_type":"application/pdf","date_created":"2021-06-23T13:09:34Z","relation":"main_file","creator":"asandaue","file_id":"9596","file_size":2114557,"checksum":"cd582d67ace7151078e46b3a896871a9","success":1,"file_name":"2021_RSCAdvances_Dar.pdf","date_updated":"2021-06-23T13:09:34Z"}],"day":"18","citation":{"chicago":"Dar, M. S., Khush Bakhat Akram, Ayesha Sohail, Fatima Arif, Fatemeh Zabihi, Shengyuan Yang, Shamsa Munir, Meifang Zhu, M. Abid, and Muhammad Nauman. “Heat Induction in Two-Dimensional Graphene–Fe3O4 Nanohybrids for Magnetic Hyperthermia Applications with Artificial Neural Network Modeling.” <i>RSC Advances</i>. Royal Society of Chemistry, 2021. <a href=\"https://doi.org/10.1039/d1ra03428f\">https://doi.org/10.1039/d1ra03428f</a>.","mla":"Dar, M. S., et al. “Heat Induction in Two-Dimensional Graphene–Fe3O4 Nanohybrids for Magnetic Hyperthermia Applications with Artificial Neural Network Modeling.” <i>RSC Advances</i>, vol. 11, no. 35, Royal Society of Chemistry, 2021, pp. 21702–15, doi:<a href=\"https://doi.org/10.1039/d1ra03428f\">10.1039/d1ra03428f</a>.","ama":"Dar MS, Akram KB, Sohail A, et al. Heat induction in two-dimensional graphene–Fe3O4 nanohybrids for magnetic hyperthermia applications with artificial neural network modeling. <i>RSC Advances</i>. 2021;11(35):21702-21715. doi:<a href=\"https://doi.org/10.1039/d1ra03428f\">10.1039/d1ra03428f</a>","ista":"Dar MS, Akram KB, Sohail A, Arif F, Zabihi F, Yang S, Munir S, Zhu M, Abid M, Nauman M. 2021. Heat induction in two-dimensional graphene–Fe3O4 nanohybrids for magnetic hyperthermia applications with artificial neural network modeling. RSC Advances. 11(35), 21702–21715.","ieee":"M. S. Dar <i>et al.</i>, “Heat induction in two-dimensional graphene–Fe3O4 nanohybrids for magnetic hyperthermia applications with artificial neural network modeling,” <i>RSC Advances</i>, vol. 11, no. 35. Royal Society of Chemistry, pp. 21702–21715, 2021.","apa":"Dar, M. S., Akram, K. B., Sohail, A., Arif, F., Zabihi, F., Yang, S., … Nauman, M. (2021). Heat induction in two-dimensional graphene–Fe3O4 nanohybrids for magnetic hyperthermia applications with artificial neural network modeling. <i>RSC Advances</i>. Royal Society of Chemistry. <a href=\"https://doi.org/10.1039/d1ra03428f\">https://doi.org/10.1039/d1ra03428f</a>","short":"M.S. Dar, K.B. Akram, A. Sohail, F. Arif, F. Zabihi, S. Yang, S. Munir, M. Zhu, M. Abid, M. Nauman, RSC Advances 11 (2021) 21702–21715."},"date_updated":"2023-08-08T14:23:21Z","has_accepted_license":"1","article_type":"original","volume":11,"date_created":"2021-06-19T07:27:45Z","license":"https://creativecommons.org/licenses/by/3.0/","date_published":"2021-06-18T00:00:00Z","month":"06"},{"related_material":{"record":[{"relation":"research_data","id":"13080","status":"public"}]},"date_updated":"2023-08-08T14:08:08Z","day":"15","citation":{"chicago":"Puglia, Denise, E. A. Martinez, G. C. Ménard, A. Pöschl, S. Gronin, G. C. Gardner, R. Kallaher, et al. “Closing of the Induced Gap in a Hybrid Superconductor-Semiconductor Nanowire.” <i>Physical Review B</i>. American Physical Society, 2021. <a href=\"https://doi.org/10.1103/PhysRevB.103.235201\">https://doi.org/10.1103/PhysRevB.103.235201</a>.","mla":"Puglia, Denise, et al. “Closing of the Induced Gap in a Hybrid Superconductor-Semiconductor Nanowire.” <i>Physical Review B</i>, vol. 103, no. 23, 235201, American Physical Society, 2021, doi:<a href=\"https://doi.org/10.1103/PhysRevB.103.235201\">10.1103/PhysRevB.103.235201</a>.","ista":"Puglia D, Martinez EA, Ménard GC, Pöschl A, Gronin S, Gardner GC, Kallaher R, Manfra MJ, Marcus CM, Higginbotham AP, Casparis L. 2021. Closing of the induced gap in a hybrid superconductor-semiconductor nanowire. Physical Review B. 103(23), 235201.","ama":"Puglia D, Martinez EA, Ménard GC, et al. Closing of the induced gap in a hybrid superconductor-semiconductor nanowire. <i>Physical Review B</i>. 2021;103(23). doi:<a href=\"https://doi.org/10.1103/PhysRevB.103.235201\">10.1103/PhysRevB.103.235201</a>","ieee":"D. Puglia <i>et al.</i>, “Closing of the induced gap in a hybrid superconductor-semiconductor nanowire,” <i>Physical Review B</i>, vol. 103, no. 23. American Physical Society, 2021.","apa":"Puglia, D., Martinez, E. A., Ménard, G. C., Pöschl, A., Gronin, S., Gardner, G. C., … Casparis, L. (2021). Closing of the induced gap in a hybrid superconductor-semiconductor nanowire. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.103.235201\">https://doi.org/10.1103/PhysRevB.103.235201</a>","short":"D. Puglia, E.A. Martinez, G.C. Ménard, A. Pöschl, S. Gronin, G.C. Gardner, R. Kallaher, M.J. Manfra, C.M. Marcus, A.P. Higginbotham, L. Casparis, Physical Review B 103 (2021)."},"volume":103,"article_type":"original","month":"06","date_created":"2021-06-20T22:01:33Z","date_published":"2021-06-15T00:00:00Z","issue":"23","publication":"Physical Review B","intvolume":"       103","quality_controlled":"1","main_file_link":[{"url":"https://arxiv.org/abs/2006.01275","open_access":"1"}],"publisher":"American Physical Society","status":"public","title":"Closing of the induced gap in a hybrid superconductor-semiconductor nanowire","article_number":"235201","author":[{"first_name":"Denise","last_name":"Puglia","full_name":"Puglia, Denise","id":"4D495994-AE37-11E9-AC72-31CAE5697425"},{"first_name":"E. A.","last_name":"Martinez","full_name":"Martinez, E. A."},{"last_name":"Ménard","first_name":"G. C.","full_name":"Ménard, G. C."},{"full_name":"Pöschl, A.","first_name":"A.","last_name":"Pöschl"},{"full_name":"Gronin, S.","last_name":"Gronin","first_name":"S."},{"full_name":"Gardner, G. C.","last_name":"Gardner","first_name":"G. C."},{"last_name":"Kallaher","first_name":"R.","full_name":"Kallaher, R."},{"full_name":"Manfra, M. J.","first_name":"M. J.","last_name":"Manfra"},{"last_name":"Marcus","first_name":"C. M.","full_name":"Marcus, C. M."},{"orcid":"0000-0003-2607-2363","last_name":"Higginbotham","first_name":"Andrew P","full_name":"Higginbotham, Andrew P","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Casparis, L.","first_name":"L.","last_name":"Casparis"}],"oa":1,"isi":1,"type":"journal_article","arxiv":1,"year":"2021","scopus_import":"1","doi":"10.1103/PhysRevB.103.235201","oa_version":"Preprint","language":[{"iso":"eng"}],"_id":"9570","publication_status":"published","department":[{"_id":"AnHi"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000661512500002"],"arxiv":["2006.01275"]},"abstract":[{"lang":"eng","text":"We present conductance-matrix measurements in long, three-terminal hybrid superconductor-semiconductor nanowires, and compare with theoretical predictions of a magnetic-field-driven, topological quantum phase transition. By examining the nonlocal conductance, we identify the closure of the excitation gap in the bulk of the semiconductor before the emergence of zero-bias peaks, ruling out spurious gap-closure signatures from localized states. We observe that after the gap closes, nonlocal signals and zero-bias peaks fluctuate strongly at both ends, inconsistent with a simple picture of clean topological superconductivity."}],"acknowledgement":"We acknowledge insightful discussions with K. Flensberg, E. B. Hansen, T. Karzig, R. Lutchyn, D. Pikulin, E. Prada, and R. Aguado. This work was supported by Microsoft Project Q and the Danmarks Grundforskningsfond. C.M.M. acknowledges support from the Villum Fonden. A.P.H. and L.C. contributed equally to this work.","article_processing_charge":"No","publication_identifier":{"issn":["24699950"],"eissn":["24699969"]}},{"author":[{"last_name":"Ramezani-Kebrya","first_name":"Ali","full_name":"Ramezani-Kebrya, Ali"},{"full_name":"Faghri, Fartash","first_name":"Fartash","last_name":"Faghri"},{"full_name":"Markov, Ilya","last_name":"Markov","first_name":"Ilya"},{"id":"2980135A-F248-11E8-B48F-1D18A9856A87","full_name":"Aksenov, Vitalii","last_name":"Aksenov","first_name":"Vitalii"},{"full_name":"Alistarh, Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3650-940X","last_name":"Alistarh","first_name":"Dan-Adrian"},{"first_name":"Daniel M.","last_name":"Roy","full_name":"Roy, Daniel M."}],"oa":1,"status":"public","title":"NUQSGD: Provably communication-efficient data-parallel SGD via nonuniform quantization","intvolume":"        22","publication":"Journal of Machine Learning Research","publisher":"Journal of Machine Learning Research","quality_controlled":"1","main_file_link":[{"open_access":"1","url":"https://www.jmlr.org/papers/v22/20-255.html"}],"page":"1−43","issue":"114","month":"04","date_published":"2021-04-01T00:00:00Z","date_created":"2021-06-20T22:01:33Z","article_type":"original","volume":22,"has_accepted_license":"1","date_updated":"2024-03-06T12:22:07Z","file":[{"checksum":"6428aa8bcb67768b6949c99b55d5281d","file_name":"2021_JournalOfMachineLearningResearch_Ramezani-Kebrya.pdf","success":1,"date_updated":"2021-06-23T07:09:41Z","access_level":"open_access","content_type":"application/pdf","date_created":"2021-06-23T07:09:41Z","creator":"asandaue","relation":"main_file","file_id":"9595","file_size":11237154}],"citation":{"short":"A. Ramezani-Kebrya, F. Faghri, I. Markov, V. Aksenov, D.-A. Alistarh, D.M. Roy, Journal of Machine Learning Research 22 (2021) 1−43.","apa":"Ramezani-Kebrya, A., Faghri, F., Markov, I., Aksenov, V., Alistarh, D.-A., &#38; Roy, D. M. (2021). NUQSGD: Provably communication-efficient data-parallel SGD via nonuniform quantization. <i>Journal of Machine Learning Research</i>. Journal of Machine Learning Research.","ieee":"A. Ramezani-Kebrya, F. Faghri, I. Markov, V. Aksenov, D.-A. Alistarh, and D. M. Roy, “NUQSGD: Provably communication-efficient data-parallel SGD via nonuniform quantization,” <i>Journal of Machine Learning Research</i>, vol. 22, no. 114. Journal of Machine Learning Research, p. 1−43, 2021.","ista":"Ramezani-Kebrya A, Faghri F, Markov I, Aksenov V, Alistarh D-A, Roy DM. 2021. NUQSGD: Provably communication-efficient data-parallel SGD via nonuniform quantization. Journal of Machine Learning Research. 22(114), 1−43.","ama":"Ramezani-Kebrya A, Faghri F, Markov I, Aksenov V, Alistarh D-A, Roy DM. NUQSGD: Provably communication-efficient data-parallel SGD via nonuniform quantization. <i>Journal of Machine Learning Research</i>. 2021;22(114):1−43.","mla":"Ramezani-Kebrya, Ali, et al. “NUQSGD: Provably Communication-Efficient Data-Parallel SGD via Nonuniform Quantization.” <i>Journal of Machine Learning Research</i>, vol. 22, no. 114, Journal of Machine Learning Research, 2021, p. 1−43.","chicago":"Ramezani-Kebrya, Ali, Fartash Faghri, Ilya Markov, Vitalii Aksenov, Dan-Adrian Alistarh, and Daniel M. Roy. “NUQSGD: Provably Communication-Efficient Data-Parallel SGD via Nonuniform Quantization.” <i>Journal of Machine Learning Research</i>. Journal of Machine Learning Research, 2021."},"day":"01","article_processing_charge":"No","publication_identifier":{"issn":["15324435"],"eissn":["15337928"]},"file_date_updated":"2021-06-23T07:09:41Z","abstract":[{"text":"As the size and complexity of models and datasets grow, so does the need for communication-efficient variants of stochastic gradient descent that can be deployed to perform parallel model training. One popular communication-compression method for data-parallel SGD is QSGD (Alistarh et al., 2017), which quantizes and encodes gradients to reduce communication costs. The baseline variant of QSGD provides strong theoretical guarantees, however, for practical purposes, the authors proposed a heuristic variant which we call QSGDinf, which demonstrated impressive empirical gains for distributed training of large neural networks. In this paper, we build on this work to propose a new gradient quantization scheme, and show that it has both stronger theoretical guarantees than QSGD, and matches and exceeds the empirical performance of the QSGDinf heuristic and of other compression methods.","lang":"eng"}],"department":[{"_id":"DaAl"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"arxiv":["1908.06077"]},"publication_status":"published","ddc":["000"],"_id":"9571","language":[{"iso":"eng"}],"oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"scopus_import":"1","arxiv":1,"type":"journal_article","year":"2021"},{"doi":"10.1112/blms.12446","oa_version":"Preprint","year":"2021","type":"journal_article","arxiv":1,"scopus_import":"1","abstract":[{"text":"We prove that every n-vertex tournament G has an acyclic subgraph with chromatic number at least n5/9−o(1), while there exists an n-vertex tournament G whose every acyclic subgraph has chromatic number at most n3/4+o(1). This establishes in a strong form a conjecture of Nassar and Yuster and improves on another result of theirs. Our proof combines probabilistic and spectral techniques together with some additional ideas. In particular, we prove a lemma showing that every tournament with many transitive subtournaments has a large subtournament that is almost transitive. This may be of independent interest.","lang":"eng"}],"extern":"1","article_processing_charge":"No","publication_identifier":{"eissn":["1469-2120"],"issn":["0024-6093"]},"language":[{"iso":"eng"}],"_id":"9572","publication_status":"published","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","external_id":{"arxiv":["1912.07722"]},"volume":53,"article_type":"original","month":"04","date_created":"2021-06-21T06:11:56Z","date_published":"2021-04-03T00:00:00Z","date_updated":"2023-02-23T14:01:21Z","day":"03","citation":{"apa":"Fox, J., Kwan, M. A., &#38; Sudakov, B. (2021). Acyclic subgraphs of tournaments with high chromatic number. <i>Bulletin of the London Mathematical Society</i>. Wiley. <a href=\"https://doi.org/10.1112/blms.12446\">https://doi.org/10.1112/blms.12446</a>","short":"J. Fox, M.A. Kwan, B. Sudakov, Bulletin of the London Mathematical Society 53 (2021) 619–630.","ieee":"J. Fox, M. A. Kwan, and B. Sudakov, “Acyclic subgraphs of tournaments with high chromatic number,” <i>Bulletin of the London Mathematical Society</i>, vol. 53, no. 2. Wiley, pp. 619–630, 2021.","ama":"Fox J, Kwan MA, Sudakov B. Acyclic subgraphs of tournaments with high chromatic number. <i>Bulletin of the London Mathematical Society</i>. 2021;53(2):619-630. doi:<a href=\"https://doi.org/10.1112/blms.12446\">10.1112/blms.12446</a>","ista":"Fox J, Kwan MA, Sudakov B. 2021. Acyclic subgraphs of tournaments with high chromatic number. Bulletin of the London Mathematical Society. 53(2), 619–630.","mla":"Fox, Jacob, et al. “Acyclic Subgraphs of Tournaments with High Chromatic Number.” <i>Bulletin of the London Mathematical Society</i>, vol. 53, no. 2, Wiley, 2021, pp. 619–30, doi:<a href=\"https://doi.org/10.1112/blms.12446\">10.1112/blms.12446</a>.","chicago":"Fox, Jacob, Matthew Alan Kwan, and Benny Sudakov. “Acyclic Subgraphs of Tournaments with High Chromatic Number.” <i>Bulletin of the London Mathematical Society</i>. Wiley, 2021. <a href=\"https://doi.org/10.1112/blms.12446\">https://doi.org/10.1112/blms.12446</a>."},"status":"public","title":"Acyclic subgraphs of tournaments with high chromatic number","author":[{"full_name":"Fox, Jacob","last_name":"Fox","first_name":"Jacob"},{"full_name":"Kwan, Matthew Alan","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","first_name":"Matthew Alan","last_name":"Kwan","orcid":"0000-0002-4003-7567"},{"full_name":"Sudakov, Benny","last_name":"Sudakov","first_name":"Benny"}],"oa":1,"issue":"2","publication":"Bulletin of the London Mathematical Society","intvolume":"        53","page":"619-630","main_file_link":[{"url":"https://arxiv.org/abs/1912.07722","open_access":"1"}],"quality_controlled":"1","publisher":"Wiley"},{"status":"public","title":"Massively winning configurations in the convex grabbing game on the plane","author":[{"first_name":"Martin","last_name":"Dvorak","orcid":"0000-0001-5293-214X","full_name":"Dvorak, Martin","id":"40ED02A8-C8B4-11E9-A9C0-453BE6697425"},{"full_name":"Nicholson, Sara","last_name":"Nicholson","first_name":"Sara"}],"oa":1,"publication":"Proceedings of the 33rd Canadian Conference on Computational Geometry","quality_controlled":"1","keyword":["convex grabbing game","graph grabbing game","combinatorial game","convex geometry"],"has_accepted_license":"1","month":"06","license":"https://creativecommons.org/licenses/by-nd/4.0/","date_created":"2021-06-22T15:57:11Z","date_published":"2021-06-29T00:00:00Z","conference":{"location":"Halifax, NS, Canada","start_date":"2021-08-10","end_date":"2021-08-12","name":"CCCG: Canadian Conference on Computational Geometry"},"date_updated":"2021-08-12T10:57:39Z","file":[{"content_type":"application/pdf","access_level":"open_access","file_size":381306,"relation":"main_file","file_id":"9616","creator":"mdvorak","date_created":"2021-06-28T20:23:13Z","checksum":"45accb1de9b7e0e4bb2fbfe5fd3e6239","date_updated":"2021-06-28T20:23:13Z","file_name":"Convex-Grabbing-Game_CCCG_proc_version.pdf","success":1},{"date_updated":"2021-08-12T10:57:21Z","file_name":"Convex-Grabbing-Game_FULL-VERSION.pdf","success":1,"checksum":"9199cf18c65658553487458cc24d0ab2","file_id":"9902","creator":"kschuh","relation":"main_file","file_size":403645,"date_created":"2021-08-12T10:57:21Z","content_type":"application/pdf","access_level":"open_access"}],"day":"29","citation":{"ieee":"M. Dvorak and S. Nicholson, “Massively winning configurations in the convex grabbing game on the plane,” in <i>Proceedings of the 33rd Canadian Conference on Computational Geometry</i>, Halifax, NS, Canada.","apa":"Dvorak, M., &#38; Nicholson, S. (n.d.). Massively winning configurations in the convex grabbing game on the plane. In <i>Proceedings of the 33rd Canadian Conference on Computational Geometry</i>. Halifax, NS, Canada.","short":"M. Dvorak, S. Nicholson, in:, Proceedings of the 33rd Canadian Conference on Computational Geometry, n.d.","chicago":"Dvorak, Martin, and Sara Nicholson. “Massively Winning Configurations in the Convex Grabbing Game on the Plane.” In <i>Proceedings of the 33rd Canadian Conference on Computational Geometry</i>, n.d.","mla":"Dvorak, Martin, and Sara Nicholson. “Massively Winning Configurations in the Convex Grabbing Game on the Plane.” <i>Proceedings of the 33rd Canadian Conference on Computational Geometry</i>.","ista":"Dvorak M, Nicholson S. Massively winning configurations in the convex grabbing game on the plane. Proceedings of the 33rd Canadian Conference on Computational Geometry. CCCG: Canadian Conference on Computational Geometry.","ama":"Dvorak M, Nicholson S. Massively winning configurations in the convex grabbing game on the plane. In: <i>Proceedings of the 33rd Canadian Conference on Computational Geometry</i>."},"abstract":[{"lang":"eng","text":"The convex grabbing game is a game where two players, Alice and Bob, alternate taking extremal points from the convex hull of a point set on the plane. Rational weights are given to the points. The goal of each player is to maximize the total weight over all points that they obtain. We restrict the setting to the case of binary weights. We show a construction of an arbitrarily large odd-sized point set that allows Bob to obtain almost 3/4 of the total weight. This construction answers a question asked by Matsumoto, Nakamigawa, and Sakuma in [Graphs and Combinatorics, 36/1 (2020)]. We also present an arbitrarily large even-sized point set where Bob can obtain the entirety of the total weight. Finally, we discuss conjectures about optimum moves in the convex grabbing game for both players in general."}],"article_processing_charge":"No","file_date_updated":"2021-08-12T10:57:21Z","ddc":["516"],"publication_status":"accepted","language":[{"iso":"eng"}],"_id":"9592","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"GradSch"},{"_id":"VlKo"}],"external_id":{"arxiv":["2106.11247"]},"tmp":{"image":"/image/cc_by_nd.png","short":"CC BY-ND (4.0)","name":"Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nd/4.0/legalcode"},"oa_version":"Submitted Version","arxiv":1,"type":"conference","year":"2021"},{"abstract":[{"lang":"eng","text":"In mammalian genomes, differentially methylated regions (DMRs) and histone marks including trimethylation of histone 3 lysine 27 (H3K27me3) at imprinted genes are asymmetrically inherited to control parentally-biased gene expression. However, neither parent-of-origin-specific transcription nor imprints have been comprehensively mapped at the blastocyst stage of preimplantation development. Here, we address this by integrating transcriptomic and epigenomic approaches in mouse preimplantation embryos. We find that seventy-one genes exhibit previously unreported parent-of-origin-specific expression in blastocysts (nBiX: novel blastocyst-imprinted expressed). Uniparental expression of nBiX genes disappears soon after implantation. Micro-whole-genome bisulfite sequencing (µWGBS) of individual uniparental blastocysts detects 859 DMRs. We further find that 16% of nBiX genes are associated with a DMR, whereas most are associated with parentally-biased H3K27me3, suggesting a role for Polycomb-mediated imprinting in blastocysts. nBiX genes are clustered: five clusters contained at least one published imprinted gene, and five clusters exclusively contained nBiX genes. These data suggest that early development undergoes a complex program of stage-specific imprinting involving different tiers of regulation."}],"file_date_updated":"2021-06-28T08:04:22Z","publication_identifier":{"eissn":["20411723"]},"acknowledgement":"The authors thank Robert Feil and Anton Wutz for helpful discussions and comments, Samuel Collombet and Peter Fraser for sharing embryo TAD coordinates, and Andy Riddel at the Cambridge Stem Cell Institute and Thomas Sauer at the Max Perutz Laboratories FACS facility for flow-sorting. We thank the team of the Biomedical Sequencing Facility at the CeMM and the Vienna Biocenter Core Facilities (VBCF) for support with next-generation sequencing. We are grateful to animal care teams at the University of Bath and MRC Harwell. A.C.F.P. acknowledges support from the UK Medical Research Council (MR/N000080/1 and MR/N020294/1) and Biotechnology and Biological Sciences Research Council (BB/P009506/1). L.S. is part of the FWF doctoral programme SMICH and supported by an Austrian Academy of Sciences DOC Fellowship. M.L. is funded by a Vienna Research Group for Young Investigators grant (VRG14-006) by the Vienna Science and Technology Fund (WWTF) and by the Austrian Science Fund FWF (I3786 and P31334).","article_processing_charge":"No","_id":"9601","language":[{"iso":"eng"}],"ddc":["570"],"publication_status":"published","external_id":{"isi":["000667248600005"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"SiHi"}],"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1038/s41467-021-23510-4","oa_version":"Published Version","year":"2021","type":"journal_article","isi":1,"scopus_import":"1","title":"Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3","article_number":"3804","status":"public","oa":1,"author":[{"full_name":"Santini, Laura","last_name":"Santini","first_name":"Laura"},{"first_name":"Florian","last_name":"Halbritter","full_name":"Halbritter, Florian"},{"last_name":"Titz-Teixeira","first_name":"Fabian","full_name":"Titz-Teixeira, Fabian"},{"full_name":"Suzuki, Toru","last_name":"Suzuki","first_name":"Toru"},{"first_name":"Maki","last_name":"Asami","full_name":"Asami, Maki"},{"first_name":"Xiaoyan","last_name":"Ma","full_name":"Ma, Xiaoyan"},{"full_name":"Ramesmayer, Julia","last_name":"Ramesmayer","first_name":"Julia"},{"full_name":"Lackner, Andreas","last_name":"Lackner","first_name":"Andreas"},{"full_name":"Warr, Nick","last_name":"Warr","first_name":"Nick"},{"last_name":"Pauler","orcid":"0000-0002-7462-0048","first_name":"Florian","full_name":"Pauler, Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","first_name":"Simon","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer"},{"full_name":"Laue, Ernest","last_name":"Laue","first_name":"Ernest"},{"full_name":"Farlik, Matthias","last_name":"Farlik","first_name":"Matthias"},{"first_name":"Christoph","last_name":"Bock","full_name":"Bock, Christoph"},{"first_name":"Andreas","last_name":"Beyer","full_name":"Beyer, Andreas"},{"full_name":"Perry, Anthony C.F.","first_name":"Anthony C.F.","last_name":"Perry"},{"full_name":"Leeb, Martin","first_name":"Martin","last_name":"Leeb"}],"issue":"1","quality_controlled":"1","publisher":"Springer Nature","publication":"Nature Communications","intvolume":"        12","has_accepted_license":"1","volume":12,"article_type":"original","date_published":"2021-07-12T00:00:00Z","date_created":"2021-06-27T22:01:46Z","month":"07","citation":{"ieee":"L. Santini <i>et al.</i>, “Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021.","apa":"Santini, L., Halbritter, F., Titz-Teixeira, F., Suzuki, T., Asami, M., Ma, X., … Leeb, M. (2021). Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-23510-4\">https://doi.org/10.1038/s41467-021-23510-4</a>","short":"L. Santini, F. Halbritter, F. Titz-Teixeira, T. Suzuki, M. Asami, X. Ma, J. Ramesmayer, A. Lackner, N. Warr, F. Pauler, S. Hippenmeyer, E. Laue, M. Farlik, C. Bock, A. Beyer, A.C.F. Perry, M. Leeb, Nature Communications 12 (2021).","mla":"Santini, Laura, et al. “Genomic Imprinting in Mouse Blastocysts Is Predominantly Associated with H3K27me3.” <i>Nature Communications</i>, vol. 12, no. 1, 3804, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23510-4\">10.1038/s41467-021-23510-4</a>.","ama":"Santini L, Halbritter F, Titz-Teixeira F, et al. Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-23510-4\">10.1038/s41467-021-23510-4</a>","ista":"Santini L, Halbritter F, Titz-Teixeira F, Suzuki T, Asami M, Ma X, Ramesmayer J, Lackner A, Warr N, Pauler F, Hippenmeyer S, Laue E, Farlik M, Bock C, Beyer A, Perry ACF, Leeb M. 2021. Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3. Nature Communications. 12(1), 3804.","chicago":"Santini, Laura, Florian Halbritter, Fabian Titz-Teixeira, Toru Suzuki, Maki Asami, Xiaoyan Ma, Julia Ramesmayer, et al. “Genomic Imprinting in Mouse Blastocysts Is Predominantly Associated with H3K27me3.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23510-4\">https://doi.org/10.1038/s41467-021-23510-4</a>."},"day":"12","file":[{"checksum":"75dd89d09945185b2d14b2434a0bcb50","success":1,"file_name":"2021_NatureCommunications_Santini.pdf","date_updated":"2021-06-28T08:04:22Z","access_level":"open_access","content_type":"application/pdf","date_created":"2021-06-28T08:04:22Z","file_size":2156554,"creator":"asandaue","relation":"main_file","file_id":"9608"}],"date_updated":"2023-08-10T13:53:23Z"},{"month":"06","date_created":"2021-06-27T22:01:47Z","date_published":"2021-06-09T00:00:00Z","article_type":"original","volume":151,"has_accepted_license":"1","date_updated":"2023-08-10T13:38:00Z","file":[{"relation":"main_file","creator":"asandaue","file_id":"9612","file_size":418168,"date_created":"2021-06-28T13:33:23Z","content_type":"application/pdf","access_level":"open_access","date_updated":"2021-06-28T13:33:23Z","success":1,"file_name":"2021_JournalOfCombinatorialTheory_Pach.pdf","checksum":"15fbc9064cd9d1c777ac0043b78c8f12"}],"citation":{"chicago":"Pach, János, and István Tomon. “Erdős-Hajnal-Type Results for Monotone Paths.” <i>Journal of Combinatorial Theory. Series B</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.jctb.2021.05.004\">https://doi.org/10.1016/j.jctb.2021.05.004</a>.","ama":"Pach J, Tomon I. Erdős-Hajnal-type results for monotone paths. <i>Journal of Combinatorial Theory Series B</i>. 2021;151:21-37. doi:<a href=\"https://doi.org/10.1016/j.jctb.2021.05.004\">10.1016/j.jctb.2021.05.004</a>","ista":"Pach J, Tomon I. 2021. Erdős-Hajnal-type results for monotone paths. Journal of Combinatorial Theory. Series B. 151, 21–37.","mla":"Pach, János, and István Tomon. “Erdős-Hajnal-Type Results for Monotone Paths.” <i>Journal of Combinatorial Theory. Series B</i>, vol. 151, Elsevier, 2021, pp. 21–37, doi:<a href=\"https://doi.org/10.1016/j.jctb.2021.05.004\">10.1016/j.jctb.2021.05.004</a>.","short":"J. Pach, I. Tomon, Journal of Combinatorial Theory. Series B 151 (2021) 21–37.","apa":"Pach, J., &#38; Tomon, I. (2021). Erdős-Hajnal-type results for monotone paths. <i>Journal of Combinatorial Theory. Series B</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jctb.2021.05.004\">https://doi.org/10.1016/j.jctb.2021.05.004</a>","ieee":"J. Pach and I. Tomon, “Erdős-Hajnal-type results for monotone paths,” <i>Journal of Combinatorial Theory. Series B</i>, vol. 151. Elsevier, pp. 21–37, 2021."},"day":"09","author":[{"last_name":"Pach","first_name":"János","full_name":"Pach, János","id":"E62E3130-B088-11EA-B919-BF823C25FEA4"},{"first_name":"István","last_name":"Tomon","full_name":"Tomon, István"}],"oa":1,"status":"public","title":"Erdős-Hajnal-type results for monotone paths","intvolume":"       151","publication":"Journal of Combinatorial Theory. Series B","publisher":"Elsevier","quality_controlled":"1","page":"21-37","oa_version":"Published Version","doi":"10.1016/j.jctb.2021.05.004","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"scopus_import":"1","type":"journal_article","isi":1,"year":"2021","acknowledgement":"We would like to thank the anonymous referees for their useful comments and suggestions. János Pach is partially supported by Austrian Science Fund (FWF) grant Z 342-N31 and by ERC Advanced grant “GeoScape.” István Tomon is partially supported by Swiss National Science Foundation grant no. 200021_196965, and thanks the support of MIPT Moscow. Both authors are partially supported by The Russian Government in the framework of MegaGrant no. 075-15-2019-1926.","article_processing_charge":"No","publication_identifier":{"issn":["0095-8956"]},"file_date_updated":"2021-06-28T13:33:23Z","abstract":[{"text":"An ordered graph is a graph with a linear ordering on its vertex set. We prove that for every positive integer k, there exists a constant ck > 0 such that any ordered graph G on n vertices with the property that neither G nor its complement contains an induced monotone path of size k, has either a clique or an independent set of size at least n^ck . This strengthens a result of Bousquet, Lagoutte, and Thomassé, who proved the analogous result for unordered graphs.\r\nA key idea of the above paper was to show that any unordered graph on n vertices that does not contain an induced path of size k, and whose maximum degree is at most c(k)n for some small c(k) > 0, contains two disjoint linear size subsets with no edge between them. This approach fails for ordered graphs, because the analogous statement is false for k ≥ 3, by a construction of Fox. We provide some further examples showing that this statement also fails for ordered graphs avoiding other ordered trees.","lang":"eng"}],"department":[{"_id":"HeEd"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000702280800002"]},"project":[{"name":"The Wittgenstein Prize","grant_number":"Z00342","call_identifier":"FWF","_id":"268116B8-B435-11E9-9278-68D0E5697425"}],"ddc":["510"],"publication_status":"published","language":[{"iso":"eng"}],"_id":"9602"},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"SiHi"},{"_id":"LoSw"},{"_id":"PreCl"}],"project":[{"name":"Molecular Mechanisms of Radial Neuronal Migration","_id":"2625A13E-B435-11E9-9278-68D0E5697425","grant_number":"24812"},{"call_identifier":"FP7","grant_number":"618444","_id":"25D61E48-B435-11E9-9278-68D0E5697425","name":"Molecular Mechanisms of Cerebral Cortex Development"},{"_id":"260018B0-B435-11E9-9278-68D0E5697425","grant_number":"725780","call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development"}],"external_id":{"isi":["000664463600016"]},"language":[{"iso":"eng"}],"_id":"9603","ddc":["570"],"publication_status":"published","acknowledgement":"We thank the Bioimaging, Life Science, and Pre-Clinical Facilities at IST Austria; M.P. Postiglione, C. Simbriger, K. Valoskova, C. Schwayer, T. Hussain, M. Pieber, and V. Wimmer for initial experiments, technical support, and/or assistance; R. Shigemoto for sharing iv (Dnah11 mutant) mice; and M. Sixt and all members of the Hippenmeyer lab for discussion. This work was supported by National Institutes of Health grants ( R01-NS050580 to L.L. and F32MH096361 to L.A.S.). L.L. is an investigator of HHMI. N.A. received support from FWF Firnberg-Programm ( T 1031 ). A.H.H. is a recipient of a DOC Fellowship (24812) of the Austrian Academy of Sciences . This work also received support from IST Austria institutional funds , FWF SFB F78 to S.H., the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme ( FP7/2007-2013 ) under REA grant agreement no 618444 to S.H., and the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme (grant agreement no. 725780 LinPro ) to S.H.","article_processing_charge":"No","file_date_updated":"2021-06-28T14:06:24Z","publication_identifier":{"eissn":["22111247"]},"ec_funded":1,"abstract":[{"lang":"eng","text":"Mosaic analysis with double markers (MADM) offers one approach to visualize and concomitantly manipulate genetically defined cells in mice with single-cell resolution. MADM applications include the analysis of lineage, single-cell morphology and physiology, genomic imprinting phenotypes, and dissection of cell-autonomous gene functions in vivo in health and disease. Yet, MADM can only be applied to <25% of all mouse genes on select chromosomes to date. To overcome this limitation, we generate transgenic mice with knocked-in MADM cassettes near the centromeres of all 19 autosomes and validate their use across organs. With this resource, >96% of the entire mouse genome can now be subjected to single-cell genetic mosaic analysis. Beyond a proof of principle, we apply our MADM library to systematically trace sister chromatid segregation in distinct mitotic cell lineages. We find striking chromosome-specific biases in segregation patterns, reflecting a putative mechanism for the asymmetric segregation of genetic determinants in somatic stem cell division."}],"type":"journal_article","year":"2021","isi":1,"scopus_import":"1","oa_version":"Published Version","doi":"10.1016/j.celrep.2021.109274","tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"publication":"Cell Reports","intvolume":"        35","quality_controlled":"1","publisher":"Cell Press","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"PreCl"}],"issue":"12","author":[{"first_name":"Ximena","last_name":"Contreras","full_name":"Contreras, Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Nicole","last_name":"Amberg","orcid":"0000-0002-3183-8207","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","full_name":"Amberg, Nicole"},{"full_name":"Davaatseren, Amarbayasgalan","id":"70ADC922-B424-11E9-99E3-BA18E6697425","last_name":"Davaatseren","first_name":"Amarbayasgalan"},{"last_name":"Hansen","first_name":"Andi H","full_name":"Hansen, Andi H","id":"38853E16-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Sonntag","first_name":"Johanna","full_name":"Sonntag, Johanna","id":"32FE7D7C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Andersen","first_name":"Lill","full_name":"Andersen, Lill"},{"first_name":"Tina","last_name":"Bernthaler","full_name":"Bernthaler, Tina"},{"full_name":"Streicher, Carmen","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","first_name":"Carmen","last_name":"Streicher"},{"full_name":"Heger, Anna-Magdalena","id":"4B76FFD2-F248-11E8-B48F-1D18A9856A87","last_name":"Heger","first_name":"Anna-Magdalena"},{"first_name":"Randy L.","last_name":"Johnson","full_name":"Johnson, Randy L."},{"first_name":"Lindsay A.","last_name":"Schwarz","full_name":"Schwarz, Lindsay A."},{"full_name":"Luo, Liqun","last_name":"Luo","first_name":"Liqun"},{"last_name":"Rülicke","first_name":"Thomas","full_name":"Rülicke, Thomas"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","first_name":"Simon"}],"oa":1,"status":"public","title":"A genome-wide library of MADM mice for single-cell genetic mosaic analysis","article_number":"109274","date_updated":"2023-08-10T13:55:00Z","citation":{"ieee":"X. Contreras <i>et al.</i>, “A genome-wide library of MADM mice for single-cell genetic mosaic analysis,” <i>Cell Reports</i>, vol. 35, no. 12. Cell Press, 2021.","apa":"Contreras, X., Amberg, N., Davaatseren, A., Hansen, A. H., Sonntag, J., Andersen, L., … Hippenmeyer, S. (2021). A genome-wide library of MADM mice for single-cell genetic mosaic analysis. <i>Cell Reports</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.celrep.2021.109274\">https://doi.org/10.1016/j.celrep.2021.109274</a>","short":"X. Contreras, N. Amberg, A. Davaatseren, A.H. Hansen, J. Sonntag, L. Andersen, T. Bernthaler, C. Streicher, A.-M. Heger, R.L. Johnson, L.A. Schwarz, L. Luo, T. Rülicke, S. Hippenmeyer, Cell Reports 35 (2021).","mla":"Contreras, Ximena, et al. “A Genome-Wide Library of MADM Mice for Single-Cell Genetic Mosaic Analysis.” <i>Cell Reports</i>, vol. 35, no. 12, 109274, Cell Press, 2021, doi:<a href=\"https://doi.org/10.1016/j.celrep.2021.109274\">10.1016/j.celrep.2021.109274</a>.","ama":"Contreras X, Amberg N, Davaatseren A, et al. A genome-wide library of MADM mice for single-cell genetic mosaic analysis. <i>Cell Reports</i>. 2021;35(12). doi:<a href=\"https://doi.org/10.1016/j.celrep.2021.109274\">10.1016/j.celrep.2021.109274</a>","ista":"Contreras X, Amberg N, Davaatseren A, Hansen AH, Sonntag J, Andersen L, Bernthaler T, Streicher C, Heger A-M, Johnson RL, Schwarz LA, Luo L, Rülicke T, Hippenmeyer S. 2021. A genome-wide library of MADM mice for single-cell genetic mosaic analysis. Cell Reports. 35(12), 109274.","chicago":"Contreras, Ximena, Nicole Amberg, Amarbayasgalan Davaatseren, Andi H Hansen, Johanna Sonntag, Lill Andersen, Tina Bernthaler, et al. “A Genome-Wide Library of MADM Mice for Single-Cell Genetic Mosaic Analysis.” <i>Cell Reports</i>. Cell Press, 2021. <a href=\"https://doi.org/10.1016/j.celrep.2021.109274\">https://doi.org/10.1016/j.celrep.2021.109274</a>."},"day":"22","file":[{"content_type":"application/pdf","access_level":"open_access","relation":"main_file","creator":"asandaue","file_id":"9613","file_size":7653149,"date_created":"2021-06-28T14:06:24Z","checksum":"d49520fdcbbb5c2f883bddb67cee5d77","date_updated":"2021-06-28T14:06:24Z","file_name":"2021_CellReports_Contreras.pdf","success":1}],"related_material":{"link":[{"url":"https://ist.ac.at/en/news/boost-for-mouse-genetic-analysis/","relation":"press_release","description":"News on IST Homepage"}]},"month":"06","date_published":"2021-06-22T00:00:00Z","date_created":"2021-06-27T22:01:48Z","article_type":"original","volume":35,"has_accepted_license":"1"},{"author":[{"orcid":"0000-0002-5372-7890","last_name":"Biswas","first_name":"Ranita","id":"3C2B033E-F248-11E8-B48F-1D18A9856A87","full_name":"Biswas, Ranita"},{"id":"34D2A09C-F248-11E8-B48F-1D18A9856A87","full_name":"Cultrera di Montesano, Sebastiano","first_name":"Sebastiano","orcid":"0000-0001-6249-0832","last_name":"Cultrera di Montesano"},{"first_name":"Herbert","last_name":"Edelsbrunner","orcid":"0000-0002-9823-6833","id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert"},{"last_name":"Saghafian","first_name":"Morteza","full_name":"Saghafian, Morteza"}],"oa":1,"status":"public","article_number":"16","title":"Counting cells of order-k voronoi tessellations in ℝ<sup>3</sup> with morse theory","intvolume":"       189","publication":"Leibniz International Proceedings in Informatics","publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","quality_controlled":"1","month":"06","date_created":"2021-06-27T22:01:48Z","date_published":"2021-06-02T00:00:00Z","volume":189,"has_accepted_license":"1","date_updated":"2023-02-23T14:02:28Z","file":[{"date_created":"2021-06-28T13:11:39Z","file_id":"9611","creator":"asandaue","relation":"main_file","file_size":727817,"access_level":"open_access","content_type":"application/pdf","file_name":"2021_LIPIcs_Biswas.pdf","success":1,"date_updated":"2021-06-28T13:11:39Z","checksum":"22b11a719018b22ecba2471b51f2eb40"}],"day":"02","citation":{"chicago":"Biswas, Ranita, Sebastiano Cultrera di Montesano, Herbert Edelsbrunner, and Morteza Saghafian. “Counting Cells of Order-k Voronoi Tessellations in ℝ<sup>3</sup> with Morse Theory.” In <i>Leibniz International Proceedings in Informatics</i>, Vol. 189. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.16\">https://doi.org/10.4230/LIPIcs.SoCG.2021.16</a>.","mla":"Biswas, Ranita, et al. “Counting Cells of Order-k Voronoi Tessellations in ℝ<sup>3</sup> with Morse Theory.” <i>Leibniz International Proceedings in Informatics</i>, vol. 189, 16, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.16\">10.4230/LIPIcs.SoCG.2021.16</a>.","ama":"Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. Counting cells of order-k voronoi tessellations in ℝ<sup>3</sup> with morse theory. In: <i>Leibniz International Proceedings in Informatics</i>. Vol 189. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2021. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.16\">10.4230/LIPIcs.SoCG.2021.16</a>","ista":"Biswas R, Cultrera di Montesano S, Edelsbrunner H, Saghafian M. 2021. Counting cells of order-k voronoi tessellations in ℝ<sup>3</sup> with morse theory. Leibniz International Proceedings in Informatics. SoCG: International Symposium on Computational Geometry, LIPIcs, vol. 189, 16.","ieee":"R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, and M. Saghafian, “Counting cells of order-k voronoi tessellations in ℝ<sup>3</sup> with morse theory,” in <i>Leibniz International Proceedings in Informatics</i>, Online, 2021, vol. 189.","apa":"Biswas, R., Cultrera di Montesano, S., Edelsbrunner, H., &#38; Saghafian, M. (2021). Counting cells of order-k voronoi tessellations in ℝ<sup>3</sup> with morse theory. In <i>Leibniz International Proceedings in Informatics</i> (Vol. 189). Online: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.16\">https://doi.org/10.4230/LIPIcs.SoCG.2021.16</a>","short":"R. Biswas, S. Cultrera di Montesano, H. Edelsbrunner, M. Saghafian, in:, Leibniz International Proceedings in Informatics, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021."},"conference":{"location":"Online","start_date":"2021-06-07","end_date":"2021-06-11","name":"SoCG: International Symposium on Computational Geometry"},"article_processing_charge":"No","alternative_title":["LIPIcs"],"publication_identifier":{"issn":["18688969"],"isbn":["9783959771849"]},"file_date_updated":"2021-06-28T13:11:39Z","ec_funded":1,"abstract":[{"text":"Generalizing Lee’s inductive argument for counting the cells of higher order Voronoi tessellations in ℝ² to ℝ³, we get precise relations in terms of Morse theoretic quantities for piecewise constant functions on planar arrangements. Specifically, we prove that for a generic set of n ≥ 5 points in ℝ³, the number of regions in the order-k Voronoi tessellation is N_{k-1} - binom(k,2)n + n, for 1 ≤ k ≤ n-1, in which N_{k-1} is the sum of Euler characteristics of these function’s first k-1 sublevel sets. We get similar expressions for the vertices, edges, and polygons of the order-k Voronoi tessellation.","lang":"eng"}],"department":[{"_id":"HeEd"}],"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","project":[{"_id":"266A2E9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"788183","name":"Alpha Shape Theory Extended"},{"name":"The Wittgenstein Prize","_id":"268116B8-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"Z00342"},{"grant_number":"I4887","_id":"0aa4bc98-070f-11eb-9043-e6fff9c6a316","name":"Discretization in Geometry and Dynamics"}],"publication_status":"published","ddc":["516"],"_id":"9604","language":[{"iso":"eng"}],"oa_version":"Published Version","doi":"10.4230/LIPIcs.SoCG.2021.16","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"scopus_import":"1","year":"2021","type":"conference"},{"scopus_import":"1","type":"conference","year":"2021","arxiv":1,"oa_version":"Published Version","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.4230/LIPIcs.SoCG.2021.27","external_id":{"arxiv":["2103.07823"]},"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","department":[{"_id":"HeEd"}],"ddc":["516"],"publication_status":"published","_id":"9605","language":[{"iso":"eng"}],"publication_identifier":{"issn":["18688969"],"isbn":["9783959771849"]},"file_date_updated":"2021-06-28T12:40:47Z","alternative_title":["LIPIcs"],"acknowledgement":"The authors want to thank the reviewers for many helpful comments and suggestions.","article_processing_charge":"No","abstract":[{"text":"Given a finite set A ⊂ ℝ^d, let Cov_{r,k} denote the set of all points within distance r to at least k points of A. Allowing r and k to vary, we obtain a 2-parameter family of spaces that grow larger when r increases or k decreases, called the multicover bifiltration. Motivated by the problem of computing the homology of this bifiltration, we introduce two closely related combinatorial bifiltrations, one polyhedral and the other simplicial, which are both topologically equivalent to the multicover bifiltration and far smaller than a Čech-based model considered in prior work of Sheehy. Our polyhedral construction is a bifiltration of the rhomboid tiling of Edelsbrunner and Osang, and can be efficiently computed using a variant of an algorithm given by these authors as well. Using an implementation for dimension 2 and 3, we provide experimental results. Our simplicial construction is useful for understanding the polyhedral construction and proving its correctness. ","lang":"eng"}],"file":[{"access_level":"open_access","content_type":"application/pdf","date_created":"2021-06-28T12:40:47Z","relation":"main_file","creator":"cziletti","file_id":"9610","file_size":"1367983","checksum":"0de217501e7ba8b267d58deed0d51761","success":1,"file_name":"2021_LIPIcs_Corbet.pdf","date_updated":"2021-06-28T12:40:47Z"}],"citation":{"chicago":"Corbet, René, Michael Kerber, Michael Lesnick, and Georg F Osang. “Computing the Multicover Bifiltration.” In <i>Leibniz International Proceedings in Informatics</i>, Vol. 189. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.27\">https://doi.org/10.4230/LIPIcs.SoCG.2021.27</a>.","ista":"Corbet R, Kerber M, Lesnick M, Osang GF. 2021. Computing the multicover bifiltration. Leibniz International Proceedings in Informatics. SoCG: International Symposium on Computational Geometry, LIPIcs, vol. 189, 27.","ama":"Corbet R, Kerber M, Lesnick M, Osang GF. Computing the multicover bifiltration. In: <i>Leibniz International Proceedings in Informatics</i>. Vol 189. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2021. doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.27\">10.4230/LIPIcs.SoCG.2021.27</a>","mla":"Corbet, René, et al. “Computing the Multicover Bifiltration.” <i>Leibniz International Proceedings in Informatics</i>, vol. 189, 27, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021, doi:<a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.27\">10.4230/LIPIcs.SoCG.2021.27</a>.","short":"R. Corbet, M. Kerber, M. Lesnick, G.F. Osang, in:, Leibniz International Proceedings in Informatics, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2021.","apa":"Corbet, R., Kerber, M., Lesnick, M., &#38; Osang, G. F. (2021). Computing the multicover bifiltration. In <i>Leibniz International Proceedings in Informatics</i> (Vol. 189). Online: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.SoCG.2021.27\">https://doi.org/10.4230/LIPIcs.SoCG.2021.27</a>","ieee":"R. Corbet, M. Kerber, M. Lesnick, and G. F. Osang, “Computing the multicover bifiltration,” in <i>Leibniz International Proceedings in Informatics</i>, Online, 2021, vol. 189."},"day":"02","date_updated":"2023-10-04T12:03:39Z","related_material":{"record":[{"id":"12709","relation":"later_version","status":"public"}],"link":[{"relation":"extended_version","url":"https://arxiv.org/abs/2103.07823"}]},"conference":{"end_date":"2021-06-11","location":"Online","start_date":"2021-06-07","name":"SoCG: International Symposium on Computational Geometry"},"date_published":"2021-06-02T00:00:00Z","date_created":"2021-06-27T22:01:49Z","month":"06","has_accepted_license":"1","volume":189,"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","quality_controlled":"1","intvolume":"       189","publication":"Leibniz International Proceedings in Informatics","oa":1,"author":[{"first_name":"René","last_name":"Corbet","full_name":"Corbet, René"},{"last_name":"Kerber","first_name":"Michael","full_name":"Kerber, Michael"},{"full_name":"Lesnick, Michael","last_name":"Lesnick","first_name":"Michael"},{"first_name":"Georg F","last_name":"Osang","orcid":"0000-0002-8882-5116","id":"464B40D6-F248-11E8-B48F-1D18A9856A87","full_name":"Osang, Georg F"}],"article_number":"27","title":"Computing the multicover bifiltration","status":"public"},{"title":"Propagation of first and second sound in a two-dimensional Fermi superfluid","article_number":"L061303","status":"public","oa":1,"author":[{"last_name":"Tononi","first_name":"A.","full_name":"Tononi, A."},{"full_name":"Cappellaro, Alberto","id":"9d13b3cb-30a2-11eb-80dc-f772505e8660","first_name":"Alberto","orcid":"0000-0001-6110-2359","last_name":"Cappellaro"},{"orcid":"0000-0001-8823-9777","last_name":"Bighin","first_name":"Giacomo","id":"4CA96FD4-F248-11E8-B48F-1D18A9856A87","full_name":"Bighin, Giacomo"},{"last_name":"Salasnich","first_name":"L.","full_name":"Salasnich, L."}],"issue":"6","main_file_link":[{"url":"https://arxiv.org/abs/2009.06491","open_access":"1"}],"quality_controlled":"1","publisher":"American Physical Society","publication":"Physical Review A","intvolume":"       103","volume":103,"article_type":"letter_note","date_created":"2021-06-27T22:01:49Z","date_published":"2021-06-01T00:00:00Z","month":"06","day":"01","citation":{"ieee":"A. Tononi, A. Cappellaro, G. Bighin, and L. Salasnich, “Propagation of first and second sound in a two-dimensional Fermi superfluid,” <i>Physical Review A</i>, vol. 103, no. 6. American Physical Society, 2021.","apa":"Tononi, A., Cappellaro, A., Bighin, G., &#38; Salasnich, L. (2021). Propagation of first and second sound in a two-dimensional Fermi superfluid. <i>Physical Review A</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevA.103.L061303\">https://doi.org/10.1103/PhysRevA.103.L061303</a>","short":"A. Tononi, A. Cappellaro, G. Bighin, L. Salasnich, Physical Review A 103 (2021).","chicago":"Tononi, A., Alberto Cappellaro, Giacomo Bighin, and L. Salasnich. “Propagation of First and Second Sound in a Two-Dimensional Fermi Superfluid.” <i>Physical Review A</i>. American Physical Society, 2021. <a href=\"https://doi.org/10.1103/PhysRevA.103.L061303\">https://doi.org/10.1103/PhysRevA.103.L061303</a>.","mla":"Tononi, A., et al. “Propagation of First and Second Sound in a Two-Dimensional Fermi Superfluid.” <i>Physical Review A</i>, vol. 103, no. 6, L061303, American Physical Society, 2021, doi:<a href=\"https://doi.org/10.1103/PhysRevA.103.L061303\">10.1103/PhysRevA.103.L061303</a>.","ista":"Tononi A, Cappellaro A, Bighin G, Salasnich L. 2021. Propagation of first and second sound in a two-dimensional Fermi superfluid. Physical Review A. 103(6), L061303.","ama":"Tononi A, Cappellaro A, Bighin G, Salasnich L. Propagation of first and second sound in a two-dimensional Fermi superfluid. <i>Physical Review A</i>. 2021;103(6). doi:<a href=\"https://doi.org/10.1103/PhysRevA.103.L061303\">10.1103/PhysRevA.103.L061303</a>"},"date_updated":"2023-08-10T13:37:25Z","abstract":[{"lang":"eng","text":"Sound propagation is a macroscopic manifestation of the interplay between the equilibrium thermodynamics and the dynamical transport properties of fluids. Here, for a two-dimensional system of ultracold fermions, we calculate the first and second sound velocities across the whole BCS-BEC crossover, and we analyze the system response to an external perturbation. In the low-temperature regime we reproduce the recent measurements [Phys. Rev. Lett. 124, 240403 (2020)] of the first sound velocity, which, due to the decoupling of density and entropy fluctuations, is the sole mode excited by a density probe. Conversely, a heat perturbation excites only the second sound, which, being sensitive to the superfluid depletion, vanishes in the deep BCS regime and jumps discontinuously to zero at the Berezinskii-Kosterlitz-Thouless superfluid transition. A mixing between the modes occurs only in the finite-temperature BEC regime, where our theory converges to the purely bosonic results."}],"publication_identifier":{"eissn":["24699934"],"issn":["24699926"]},"article_processing_charge":"No","acknowledgement":"G.B. acknowledges support from the Austrian Science Fund (FWF), under Project No. M2641-N27. This work was\r\npartially supported by the University of Padua, BIRD project “Superfluid properties of Fermi gases in optical potentials.”\r\nThe authors thank Miki Ota, Tomoki Ozawa, Sandro Stringari, Tilman Enss, Hauke Biss, Henning Moritz, and Nicolò Defenu for fruitful discussions. The authors thank Henning Moritz and Markus Bohlen for providing their experimental\r\ndata.","_id":"9606","language":[{"iso":"eng"}],"publication_status":"published","external_id":{"arxiv":["2009.06491"],"isi":["000662296700014"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"MiLe"}],"doi":"10.1103/PhysRevA.103.L061303","oa_version":"Preprint","isi":1,"arxiv":1,"type":"journal_article","year":"2021","scopus_import":"1"},{"quality_controlled":"1","publisher":"eLife Sciences Publications","publication":"eLife","intvolume":"        10","oa":1,"author":[{"full_name":"Bespalov, Anton","first_name":"Anton","last_name":"Bespalov"},{"last_name":"Bernard","first_name":"René","full_name":"Bernard, René"},{"full_name":"Gilis, Anja","last_name":"Gilis","first_name":"Anja"},{"full_name":"Gerlach, Björn","last_name":"Gerlach","first_name":"Björn"},{"first_name":"Javier","last_name":"Guillén","full_name":"Guillén, Javier"},{"full_name":"Castagné, Vincent","first_name":"Vincent","last_name":"Castagné"},{"full_name":"Lefevre, Isabel A.","last_name":"Lefevre","first_name":"Isabel A."},{"last_name":"Ducrey","first_name":"Fiona","full_name":"Ducrey, Fiona"},{"full_name":"Monk, Lee","last_name":"Monk","first_name":"Lee"},{"first_name":"Sandrine","last_name":"Bongiovanni","full_name":"Bongiovanni, Sandrine"},{"full_name":"Altevogt, Bruce","first_name":"Bruce","last_name":"Altevogt"},{"full_name":"Arroyo-Araujo, María","last_name":"Arroyo-Araujo","first_name":"María"},{"first_name":"Lior","last_name":"Bikovski","full_name":"Bikovski, Lior"},{"last_name":"De Bruin","first_name":"Natasja","full_name":"De Bruin, Natasja"},{"full_name":"Castaños-Vélez, Esmeralda","first_name":"Esmeralda","last_name":"Castaños-Vélez"},{"last_name":"Dityatev","first_name":"Alexander","full_name":"Dityatev, Alexander"},{"last_name":"Emmerich","first_name":"Christoph H.","full_name":"Emmerich, Christoph H."},{"full_name":"Fares, Raafat","first_name":"Raafat","last_name":"Fares"},{"last_name":"Ferland-Beckham","first_name":"Chantelle","full_name":"Ferland-Beckham, Chantelle"},{"first_name":"Christelle","last_name":"Froger-Colléaux","full_name":"Froger-Colléaux, Christelle"},{"full_name":"Gailus-Durner, Valerie","first_name":"Valerie","last_name":"Gailus-Durner"},{"first_name":"Sabine M.","last_name":"Hölter","full_name":"Hölter, Sabine M."},{"full_name":"Hofmann, Martine Cj","first_name":"Martine Cj","last_name":"Hofmann"},{"last_name":"Kabitzke","first_name":"Patricia","full_name":"Kabitzke, Patricia"},{"full_name":"Kas, Martien Jh","first_name":"Martien Jh","last_name":"Kas"},{"full_name":"Kurreck, Claudia","first_name":"Claudia","last_name":"Kurreck"},{"first_name":"Paul","last_name":"Moser","full_name":"Moser, Paul"},{"last_name":"Pietraszek","first_name":"Malgorzata","full_name":"Pietraszek, Malgorzata"},{"last_name":"Popik","first_name":"Piotr","full_name":"Popik, Piotr"},{"first_name":"Heidrun","last_name":"Potschka","full_name":"Potschka, Heidrun"},{"full_name":"Prado Montes De Oca, Ernesto","last_name":"Prado Montes De Oca","first_name":"Ernesto"},{"full_name":"Restivo, Leonardo","first_name":"Leonardo","last_name":"Restivo"},{"full_name":"Riedel, Gernot","first_name":"Gernot","last_name":"Riedel"},{"full_name":"Ritskes-Hoitinga, Merel","first_name":"Merel","last_name":"Ritskes-Hoitinga"},{"full_name":"Samardzic, Janko","last_name":"Samardzic","first_name":"Janko"},{"full_name":"Schunn, Michael","id":"4272DB4A-F248-11E8-B48F-1D18A9856A87","first_name":"Michael","orcid":"0000-0003-4326-5300","last_name":"Schunn"},{"full_name":"Stöger, Claudia","last_name":"Stöger","first_name":"Claudia"},{"last_name":"Voikar","first_name":"Vootele","full_name":"Voikar, Vootele"},{"first_name":"Jan","last_name":"Vollert","full_name":"Vollert, Jan"},{"full_name":"Wever, Kimberley E.","last_name":"Wever","first_name":"Kimberley E."},{"last_name":"Wuyts","first_name":"Kathleen","full_name":"Wuyts, Kathleen"},{"first_name":"Malcolm R.","last_name":"Macleod","full_name":"Macleod, Malcolm R."},{"full_name":"Dirnagl, Ulrich","last_name":"Dirnagl","first_name":"Ulrich"},{"full_name":"Steckler, Thomas","first_name":"Thomas","last_name":"Steckler"}],"title":"Introduction to the EQIPD quality system","status":"public","day":"24","citation":{"apa":"Bespalov, A., Bernard, R., Gilis, A., Gerlach, B., Guillén, J., Castagné, V., … Steckler, T. (2021). Introduction to the EQIPD quality system. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.63294\">https://doi.org/10.7554/eLife.63294</a>","short":"A. Bespalov, R. Bernard, A. Gilis, B. Gerlach, J. Guillén, V. Castagné, I.A. Lefevre, F. Ducrey, L. Monk, S. Bongiovanni, B. Altevogt, M. Arroyo-Araujo, L. Bikovski, N. De Bruin, E. Castaños-Vélez, A. Dityatev, C.H. Emmerich, R. Fares, C. Ferland-Beckham, C. Froger-Colléaux, V. Gailus-Durner, S.M. Hölter, M.C. Hofmann, P. Kabitzke, M.J. Kas, C. Kurreck, P. Moser, M. Pietraszek, P. Popik, H. Potschka, E. Prado Montes De Oca, L. Restivo, G. Riedel, M. Ritskes-Hoitinga, J. Samardzic, M. Schunn, C. Stöger, V. Voikar, J. Vollert, K.E. Wever, K. Wuyts, M.R. Macleod, U. Dirnagl, T. Steckler, ELife 10 (2021).","ieee":"A. Bespalov <i>et al.</i>, “Introduction to the EQIPD quality system,” <i>eLife</i>, vol. 10. eLife Sciences Publications, 2021.","ama":"Bespalov A, Bernard R, Gilis A, et al. Introduction to the EQIPD quality system. <i>eLife</i>. 2021;10. doi:<a href=\"https://doi.org/10.7554/eLife.63294\">10.7554/eLife.63294</a>","ista":"Bespalov A, Bernard R, Gilis A, Gerlach B, Guillén J, Castagné V, Lefevre IA, Ducrey F, Monk L, Bongiovanni S, Altevogt B, Arroyo-Araujo M, Bikovski L, De Bruin N, Castaños-Vélez E, Dityatev A, Emmerich CH, Fares R, Ferland-Beckham C, Froger-Colléaux C, Gailus-Durner V, Hölter SM, Hofmann MC, Kabitzke P, Kas MJ, Kurreck C, Moser P, Pietraszek M, Popik P, Potschka H, Prado Montes De Oca E, Restivo L, Riedel G, Ritskes-Hoitinga M, Samardzic J, Schunn M, Stöger C, Voikar V, Vollert J, Wever KE, Wuyts K, Macleod MR, Dirnagl U, Steckler T. 2021. Introduction to the EQIPD quality system. eLife. 10.","mla":"Bespalov, Anton, et al. “Introduction to the EQIPD Quality System.” <i>ELife</i>, vol. 10, eLife Sciences Publications, 2021, doi:<a href=\"https://doi.org/10.7554/eLife.63294\">10.7554/eLife.63294</a>.","chicago":"Bespalov, Anton, René Bernard, Anja Gilis, Björn Gerlach, Javier Guillén, Vincent Castagné, Isabel A. Lefevre, et al. “Introduction to the EQIPD Quality System.” <i>ELife</i>. eLife Sciences Publications, 2021. <a href=\"https://doi.org/10.7554/eLife.63294\">https://doi.org/10.7554/eLife.63294</a>."},"file":[{"access_level":"open_access","content_type":"application/pdf","date_created":"2021-06-28T11:35:30Z","file_id":"9609","relation":"main_file","creator":"asandaue","file_size":2500720,"checksum":"885b746051a7a6b6e24e3d2781a48fde","file_name":"2021_ELife_Bespalov.pdf","success":1,"date_updated":"2021-06-28T11:35:30Z"}],"date_updated":"2023-08-10T13:36:50Z","date_created":"2021-06-27T22:01:49Z","date_published":"2021-05-24T00:00:00Z","month":"05","has_accepted_license":"1","volume":10,"article_type":"original","external_id":{"isi":["000661272000001"],"pmid":["34028353"]},"department":[{"_id":"PreCl"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","language":[{"iso":"eng"}],"_id":"9607","publication_status":"published","ddc":["570"],"file_date_updated":"2021-06-28T11:35:30Z","publication_identifier":{"eissn":["2050084X"]},"acknowledgement":"This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777364. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA. The authors are very grateful to Martin Heinrich (Abbvie, Ludwigshafen, Germany) for the exceptional IT support and programming the EQIPD Planning Tool and the Creator Tool and to Dr Shai Silberberg (NINDS, USA), Dr. Renza Roncarati (PAASP Italy) and Dr Judith Homberg (Radboud University, Nijmegen) for highly stimulating contributions to the discussions and comments on earlier versions of this manuscript. We also wish to express our thanks to Dr. Sara Stöber (concentris research management GmbH, Fürstenfeldbruck, Germany) for excellent and continuous support of this project. Creation of the EQIPD Stakeholder group was supported by Noldus Information Technology bv (Wageningen, the Netherlands).","article_processing_charge":"No","abstract":[{"text":"While high risk of failure is an inherent part of developing innovative therapies, it can be reduced by adherence to evidence-based rigorous research practices. Numerous analyses conducted to date have clearly identified measures that need to be taken to improve research rigor. Supported through the European Union's Innovative Medicines Initiative, the EQIPD consortium has developed a novel preclinical research quality system that can be applied in both public and private sectors and is free for anyone to use. The EQIPD Quality System was designed to be suited to boost innovation by ensuring the generation of robust and reliable preclinical data while being lean, effective and not becoming a burden that could negatively impact the freedom to explore scientific questions. EQIPD defines research quality as the extent to which research data are fit for their intended use. Fitness, in this context, is defined by the stakeholders, who are the scientists directly involved in the research, but also their funders, sponsors, publishers, research tool manufacturers and collaboration partners such as peers in a multi-site research project. The essence of the EQIPD Quality System is the set of 18 core requirements that can be addressed flexibly, according to user-specific needs and following a user-defined trajectory. The EQIPD Quality System proposes guidance on expectations for quality-related measures, defines criteria for adequate processes (i.e., performance standards) and provides examples of how such measures can be developed and implemented. However, it does not prescribe any pre-determined solutions. EQIPD has also developed tools (for optional use) to support users in implementing the system and assessment services for those research units that successfully implement the quality system and seek formal accreditation. Building upon the feedback from users and continuous improvement, a sustainable EQIPD Quality System will ultimately serve the entire community of scientists conducting non-regulated preclinical research, by helping them generate reliable data that are fit for their intended use.","lang":"eng"}],"year":"2021","isi":1,"type":"journal_article","scopus_import":"1","oa_version":"Published Version","pmid":1,"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.7554/eLife.63294"},{"language":[{"iso":"eng"}],"_id":"9618","ddc":["539"],"publication_status":"published","department":[{"_id":"MaSe"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","project":[{"grant_number":"850899","call_identifier":"H2020","_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control"}],"external_id":{"arxiv":["2012.12276"],"isi":["000636043400048"],"pmid":["33632894"]},"ec_funded":1,"abstract":[{"text":"The control of nonequilibrium quantum dynamics in many-body systems is challenging because interactions typically lead to thermalization and a chaotic spreading throughout Hilbert space. We investigate nonequilibrium dynamics after rapid quenches in a many-body system composed of 3 to 200 strongly interacting qubits in one and two spatial dimensions. Using a programmable quantum simulator based on Rydberg atom arrays, we show that coherent revivals associated with so-called quantum many-body scars can be stabilized by periodic driving, which generates a robust subharmonic response akin to discrete time-crystalline order. We map Hilbert space dynamics, geometry dependence, phase diagrams, and system-size dependence of this emergent phenomenon, demonstrating new ways to steer complex dynamics in many-body systems and enabling potential applications in quantum information science.","lang":"eng"}],"article_processing_charge":"No","acknowledgement":"We thank many members of the Harvard AMO community, particularly E. Urbach, S. Dakoulas, and J. Doyle for their efforts enabling safe and productive operation of our laboratories during 2020. We thank D. Abanin, I. Cong, F. Machado, H. Pichler, N. Yao, B. Ye, and H. Zhou for stimulating discussions. Funding: We acknowledge financial support from the Center for Ultracold Atoms, the National Science Foundation, the Vannevar Bush Faculty Fellowship, the U.S. Department of Energy (LBNL QSA Center and grant no. DE-SC0021013), the Office of Naval Research, the Army Research Office MURI, the DARPA DRINQS program (grant no. D18AC00033), and the DARPA ONISQ program (grant no. W911NF2010021). The authors acknowledge support from the NSF Graduate Research Fellowship Program (grant DGE1745303) and The Fannie and John Hertz Foundation (D.B.); a National Defense Science and Engineering Graduate (NDSEG) fellowship (H.L.); a fellowship from the Max Planck/Harvard Research Center for Quantum Optics (G.S.); Gordon College (T.T.W.); the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 850899) (A.A.M. and M.S.); a Department of Energy Computational Science Graduate Fellowship under award number DE-SC0021110 (N.M.); the Moore Foundation’s EPiQS Initiative grant no. GBMF4306, the NUS Development grant AY2019/2020, and the Stanford Institute of Theoretical Physics (W.W.H.); and the Miller Institute for Basic Research in Science (S.C.). Author contributions: D.B., A.O., H.L., A.K., G.S., S.E., and T.T.W. contributed to the building of the experimental setup, performed the measurements, and analyzed the data. A.A.M., N.M., W.W.H., S.C., and M.S. performed theoretical analysis. All work was supervised by M.G., V.V., and M.D.L. All authors discussed the results and contributed to the manuscript. Competing interests: M.G., V.V., and M.D.L. are co-founders and shareholders of QuEra Computing. A.O. is a shareholder of QuEra Computing. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and the supplementary materials.","file_date_updated":"2021-09-23T14:00:05Z","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"type":"journal_article","isi":1,"arxiv":1,"year":"2021","scopus_import":"1","doi":"10.1126/science.abg2530","pmid":1,"oa_version":"Preprint","issue":"6536","publication":"Science","intvolume":"       371","page":"1355-1359","keyword":["Multidisciplinary"],"quality_controlled":"1","publisher":"AAAS","status":"public","title":"Controlling quantum many-body dynamics in driven Rydberg atom arrays","author":[{"first_name":"D.","last_name":"Bluvstein","full_name":"Bluvstein, D."},{"first_name":"A.","last_name":"Omran","full_name":"Omran, A."},{"full_name":"Levine, H.","last_name":"Levine","first_name":"H."},{"full_name":"Keesling, A.","last_name":"Keesling","first_name":"A."},{"full_name":"Semeghini, G.","last_name":"Semeghini","first_name":"G."},{"full_name":"Ebadi, S.","last_name":"Ebadi","first_name":"S."},{"first_name":"T. T.","last_name":"Wang","full_name":"Wang, T. T."},{"orcid":"0000-0002-8443-1064","last_name":"Michailidis","first_name":"Alexios","full_name":"Michailidis, Alexios","id":"36EBAD38-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Maskara, N.","first_name":"N.","last_name":"Maskara"},{"full_name":"Ho, W. W.","first_name":"W. W.","last_name":"Ho"},{"first_name":"S.","last_name":"Choi","full_name":"Choi, S."},{"first_name":"Maksym","last_name":"Serbyn","orcid":"0000-0002-2399-5827","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","full_name":"Serbyn, Maksym"},{"first_name":"M.","last_name":"Greiner","full_name":"Greiner, M."},{"first_name":"V.","last_name":"Vuletić","full_name":"Vuletić, V."},{"full_name":"Lukin, M. D.","last_name":"Lukin","first_name":"M. D."}],"oa":1,"date_updated":"2023-08-10T13:57:07Z","citation":{"ieee":"D. Bluvstein <i>et al.</i>, “Controlling quantum many-body dynamics in driven Rydberg atom arrays,” <i>Science</i>, vol. 371, no. 6536. AAAS, pp. 1355–1359, 2021.","apa":"Bluvstein, D., Omran, A., Levine, H., Keesling, A., Semeghini, G., Ebadi, S., … Lukin, M. D. (2021). Controlling quantum many-body dynamics in driven Rydberg atom arrays. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.abg2530\">https://doi.org/10.1126/science.abg2530</a>","short":"D. Bluvstein, A. Omran, H. Levine, A. Keesling, G. Semeghini, S. Ebadi, T.T. Wang, A. Michailidis, N. Maskara, W.W. Ho, S. Choi, M. Serbyn, M. Greiner, V. Vuletić, M.D. Lukin, Science 371 (2021) 1355–1359.","mla":"Bluvstein, D., et al. “Controlling Quantum Many-Body Dynamics in Driven Rydberg Atom Arrays.” <i>Science</i>, vol. 371, no. 6536, AAAS, 2021, pp. 1355–59, doi:<a href=\"https://doi.org/10.1126/science.abg2530\">10.1126/science.abg2530</a>.","ama":"Bluvstein D, Omran A, Levine H, et al. Controlling quantum many-body dynamics in driven Rydberg atom arrays. <i>Science</i>. 2021;371(6536):1355-1359. doi:<a href=\"https://doi.org/10.1126/science.abg2530\">10.1126/science.abg2530</a>","ista":"Bluvstein D, Omran A, Levine H, Keesling A, Semeghini G, Ebadi S, Wang TT, Michailidis A, Maskara N, Ho WW, Choi S, Serbyn M, Greiner M, Vuletić V, Lukin MD. 2021. Controlling quantum many-body dynamics in driven Rydberg atom arrays. Science. 371(6536), 1355–1359.","chicago":"Bluvstein, D., A. Omran, H. Levine, A. Keesling, G. Semeghini, S. Ebadi, T. T. Wang, et al. “Controlling Quantum Many-Body Dynamics in Driven Rydberg Atom Arrays.” <i>Science</i>. AAAS, 2021. <a href=\"https://doi.org/10.1126/science.abg2530\">https://doi.org/10.1126/science.abg2530</a>."},"day":"26","file":[{"checksum":"0b356fd10ab9bb95177d4c047d4e9c1a","success":1,"file_name":"scars_subharmonic_combined_manuscript_2_11_2021 (2)-1.pdf","date_updated":"2021-09-23T14:00:05Z","access_level":"open_access","content_type":"application/pdf","date_created":"2021-09-23T14:00:05Z","file_size":3671159,"creator":"patrickd","relation":"main_file","file_id":"10040"}],"volume":371,"article_type":"original","has_accepted_license":"1","month":"03","date_published":"2021-03-26T00:00:00Z","date_created":"2021-06-29T12:04:05Z"},{"file_date_updated":"2021-07-01T11:21:40Z","publication_identifier":{"eisbn":["9783030795276"],"issn":["0302-9743"],"eissn":["1611-3349"],"isbn":["9783030795269"]},"article_processing_charge":"No","alternative_title":["LNCS"],"acknowledgement":"Peter Davies is supported by the European Union’s Horizon2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754411.","abstract":[{"lang":"eng","text":"In this note, we introduce a distributed twist on the classic coupon collector problem: a set of m collectors wish to each obtain a set of n coupons; for this, they can each sample coupons uniformly at random, but can also meet in pairwise interactions, during which they can exchange coupons. By doing so, they hope to reduce the number of coupons that must be sampled by each collector in order to obtain a full set. This extension is natural when considering real-world manifestations of the coupon collector phenomenon, and has been remarked upon and studied empirically (Hayes and Hannigan 2006, Ahmad et al. 2014, Delmarcelle 2019).\r\n\r\nWe provide the first theoretical analysis for such a scenario. We find that “coupon collecting with friends” can indeed significantly reduce the number of coupons each collector must sample, and raises interesting connections to the more traditional variants of the problem. While our analysis is in most cases asymptotically tight, there are several open questions raised, regarding finer-grained analysis of both “coupon collecting with friends,” and of a long-studied variant of the original problem in which a collector requires multiple full sets of coupons."}],"ec_funded":1,"project":[{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411"}],"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","department":[{"_id":"DaAl"}],"_id":"9620","language":[{"iso":"eng"}],"publication_status":"published","ddc":["000"],"oa_version":"Preprint","doi":"10.1007/978-3-030-79527-6_1","year":"2021","type":"conference","oa":1,"author":[{"orcid":"0000-0003-3650-940X","last_name":"Alistarh","first_name":"Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","full_name":"Alistarh, Dan-Adrian"},{"orcid":"0000-0002-5646-9524","last_name":"Davies","first_name":"Peter","id":"11396234-BB50-11E9-B24C-90FCE5697425","full_name":"Davies, Peter"}],"title":"Collecting coupons is faster with friends","status":"public","quality_controlled":"1","page":"3-12","publisher":"Springer Nature","publication":"Structural Information and Communication Complexity","intvolume":"     12810","date_published":"2021-06-20T00:00:00Z","date_created":"2021-07-01T11:04:43Z","month":"06","has_accepted_license":"1","volume":12810,"citation":{"apa":"Alistarh, D.-A., &#38; Davies, P. (2021). Collecting coupons is faster with friends. In <i>Structural Information and Communication Complexity</i> (Vol. 12810, pp. 3–12). Wrocław, Poland: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-79527-6_1\">https://doi.org/10.1007/978-3-030-79527-6_1</a>","short":"D.-A. Alistarh, P. Davies, in:, Structural Information and Communication Complexity, Springer Nature, 2021, pp. 3–12.","ieee":"D.-A. Alistarh and P. Davies, “Collecting coupons is faster with friends,” in <i>Structural Information and Communication Complexity</i>, Wrocław, Poland, 2021, vol. 12810, pp. 3–12.","chicago":"Alistarh, Dan-Adrian, and Peter Davies. “Collecting Coupons Is Faster with Friends.” In <i>Structural Information and Communication Complexity</i>, 12810:3–12. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/978-3-030-79527-6_1\">https://doi.org/10.1007/978-3-030-79527-6_1</a>.","ista":"Alistarh D-A, Davies P. 2021. Collecting coupons is faster with friends. Structural Information and Communication Complexity.  SIROCCO: International Colloquium on Structural Information and Communication Complexity, LNCS, vol. 12810, 3–12.","ama":"Alistarh D-A, Davies P. Collecting coupons is faster with friends. In: <i>Structural Information and Communication Complexity</i>. Vol 12810. Springer Nature; 2021:3-12. doi:<a href=\"https://doi.org/10.1007/978-3-030-79527-6_1\">10.1007/978-3-030-79527-6_1</a>","mla":"Alistarh, Dan-Adrian, and Peter Davies. “Collecting Coupons Is Faster with Friends.” <i>Structural Information and Communication Complexity</i>, vol. 12810, Springer Nature, 2021, pp. 3–12, doi:<a href=\"https://doi.org/10.1007/978-3-030-79527-6_1\">10.1007/978-3-030-79527-6_1</a>."},"day":"20","file":[{"checksum":"fe37fb9af3f5016c1084af9d6e7109bd","file_name":"Population_Coupon_Collector.pdf","date_updated":"2021-07-01T11:21:40Z","access_level":"open_access","content_type":"application/pdf","date_created":"2021-07-01T11:21:40Z","file_size":319728,"relation":"main_file","creator":"pdavies","file_id":"9621"}],"date_updated":"2023-02-23T14:02:46Z","conference":{"location":"Wrocław, Poland","start_date":"2021-06-28","end_date":"2021-07-01","name":" SIROCCO: International Colloquium on Structural Information and Communication Complexity"}},{"month":"07","date_published":"2021-07-01T00:00:00Z","date_created":"2021-07-01T14:50:17Z","degree_awarded":"PhD","has_accepted_license":"1","date_updated":"2023-09-07T13:33:27Z","citation":{"short":"S. Caballero Mancebo, Fertilization-Induced Deformations Are Controlled by the Actin Cortex and a Mitochondria-Rich Subcortical Layer in Ascidian Oocytes, Institute of Science and Technology Austria, 2021.","apa":"Caballero Mancebo, S. (2021). <i>Fertilization-induced deformations are controlled by the actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:9623\">https://doi.org/10.15479/at:ista:9623</a>","ieee":"S. Caballero Mancebo, “Fertilization-induced deformations are controlled by the actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes,” Institute of Science and Technology Austria, 2021.","chicago":"Caballero Mancebo, Silvia. “Fertilization-Induced Deformations Are Controlled by the Actin Cortex and a Mitochondria-Rich Subcortical Layer in Ascidian Oocytes.” Institute of Science and Technology Austria, 2021. <a href=\"https://doi.org/10.15479/at:ista:9623\">https://doi.org/10.15479/at:ista:9623</a>.","ista":"Caballero Mancebo S. 2021. Fertilization-induced deformations are controlled by the actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes. Institute of Science and Technology Austria.","ama":"Caballero Mancebo S. Fertilization-induced deformations are controlled by the actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes. 2021. doi:<a href=\"https://doi.org/10.15479/at:ista:9623\">10.15479/at:ista:9623</a>","mla":"Caballero Mancebo, Silvia. <i>Fertilization-Induced Deformations Are Controlled by the Actin Cortex and a Mitochondria-Rich Subcortical Layer in Ascidian Oocytes</i>. Institute of Science and Technology Austria, 2021, doi:<a href=\"https://doi.org/10.15479/at:ista:9623\">10.15479/at:ista:9623</a>."},"file":[{"checksum":"e039225a47ef32666d59bf35ddd30ecf","date_updated":"2022-07-02T22:30:06Z","file_name":"PhDThesis_SCM.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","access_level":"closed","file_size":131946790,"creator":"scaballe","relation":"source_file","file_id":"9624","embargo_to":"open_access","date_created":"2021-07-01T14:48:54Z"},{"file_name":"PhDThesis_SCM.pdf","date_updated":"2022-07-02T22:30:06Z","embargo":"2022-07-01","checksum":"dd4d78962ea94ad95e97ca7d9af08f4b","date_created":"2021-07-01T14:46:25Z","file_size":17094958,"creator":"scaballe","file_id":"9625","relation":"main_file","access_level":"open_access","content_type":"application/pdf"}],"related_material":{"record":[{"relation":"part_of_dissertation","id":"9750","status":"public"},{"relation":"part_of_dissertation","id":"9006","status":"public"}]},"author":[{"full_name":"Caballero Mancebo, Silvia","id":"2F1E1758-F248-11E8-B48F-1D18A9856A87","first_name":"Silvia","orcid":"0000-0002-5223-3346","last_name":"Caballero Mancebo"}],"oa":1,"status":"public","title":"Fertilization-induced deformations are controlled by the actin cortex and a mitochondria-rich subcortical layer in ascidian oocytes","page":"111","publisher":"Institute of Science and Technology Austria","acknowledged_ssus":[{"_id":"Bio"},{"_id":"EM-Fac"},{"_id":"NanoFab"},{"_id":"M-Shop"}],"oa_version":"Published Version","doi":"10.15479/at:ista:9623","supervisor":[{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J"}],"tmp":{"image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"type":"dissertation","year":"2021","article_processing_charge":"No","alternative_title":["ISTA Thesis"],"file_date_updated":"2022-07-02T22:30:06Z","publication_identifier":{"isbn":["978-3-99078-012-1"],"issn":["2663-337X"]},"abstract":[{"lang":"eng","text":"Cytoplasmic reorganizations are essential for morphogenesis. In large cells like oocytes, these reorganizations become crucial in patterning the oocyte for later stages of embryonic development. Ascidians oocytes reorganize their cytoplasm (ooplasm) in a spectacular manner. Ooplasmic reorganization is initiated at fertilization with the contraction of the actomyosin cortex along the animal-vegetal axis of the oocyte, driving the accumulation of cortical endoplasmic reticulum (cER), maternal mRNAs associated to it and a mitochondria-rich subcortical layer – the myoplasm – in a region of the vegetal pole termed contraction pole (CP). Here we have used the species Phallusia mammillata to investigate the changes in cell shape that accompany these reorganizations and the mechanochemical mechanisms underlining CP formation.\r\nWe report that the length of the animal-vegetal (AV) axis oscillates upon fertilization: it first undergoes a cycle of fast elongation-lengthening followed by a slow expansion of mainly the vegetal pole (VP) of the cell. We show that the fast oscillation corresponds to a dynamic polarization of the actin cortex as a result of a fertilization-induced increase in cortical tension in the oocyte that triggers a rupture of the cortex at the animal pole and the establishment of vegetal-directed cortical flows. These flows are responsible for the vegetal accumulation of actin causing the VP to flatten. \r\nWe find that the slow expansion of the VP, leading to CP formation, correlates with a relaxation of the vegetal cortex and that the myoplasm plays a role in the expansion. We show that the myoplasm is a solid-like layer that buckles under compression forces arising from the contracting actin cortex at the VP. Straightening of the myoplasm when actin flows stops, facilitates the expansion of the VP and the CP. Altogether, our results present a previously unrecognized role for the myoplasm in ascidian ooplasmic segregation. \r\n"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","department":[{"_id":"GradSch"},{"_id":"CaHe"}],"language":[{"iso":"eng"}],"_id":"9623","publication_status":"published","ddc":["570"]},{"title":"Self-adjoint extensions of bipartite Hamiltonians","status":"public","oa":1,"author":[{"full_name":"Lenz, Daniel","first_name":"Daniel","last_name":"Lenz"},{"full_name":"Weinmann, Timon","last_name":"Weinmann","first_name":"Timon"},{"last_name":"Wirth","orcid":"0000-0002-0519-4241","first_name":"Melchior","full_name":"Wirth, Melchior","id":"88644358-0A0E-11EA-8FA5-49A33DDC885E"}],"issue":"3","main_file_link":[{"url":"https://doi.org/10.1017/S0013091521000080","open_access":"1"}],"page":"443-447","quality_controlled":"1","publisher":"Cambridge University Press","publication":"Proceedings of the Edinburgh Mathematical Society","intvolume":"        64","article_type":"original","volume":64,"date_created":"2021-07-04T22:01:24Z","date_published":"2021-08-01T00:00:00Z","month":"08","day":"01","citation":{"short":"D. Lenz, T. Weinmann, M. Wirth, Proceedings of the Edinburgh Mathematical Society 64 (2021) 443–447.","apa":"Lenz, D., Weinmann, T., &#38; Wirth, M. (2021). Self-adjoint extensions of bipartite Hamiltonians. <i>Proceedings of the Edinburgh Mathematical Society</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/S0013091521000080\">https://doi.org/10.1017/S0013091521000080</a>","ieee":"D. Lenz, T. Weinmann, and M. Wirth, “Self-adjoint extensions of bipartite Hamiltonians,” <i>Proceedings of the Edinburgh Mathematical Society</i>, vol. 64, no. 3. Cambridge University Press, pp. 443–447, 2021.","chicago":"Lenz, Daniel, Timon Weinmann, and Melchior Wirth. “Self-Adjoint Extensions of Bipartite Hamiltonians.” <i>Proceedings of the Edinburgh Mathematical Society</i>. Cambridge University Press, 2021. <a href=\"https://doi.org/10.1017/S0013091521000080\">https://doi.org/10.1017/S0013091521000080</a>.","ama":"Lenz D, Weinmann T, Wirth M. Self-adjoint extensions of bipartite Hamiltonians. <i>Proceedings of the Edinburgh Mathematical Society</i>. 2021;64(3):443-447. doi:<a href=\"https://doi.org/10.1017/S0013091521000080\">10.1017/S0013091521000080</a>","ista":"Lenz D, Weinmann T, Wirth M. 2021. Self-adjoint extensions of bipartite Hamiltonians. Proceedings of the Edinburgh Mathematical Society. 64(3), 443–447.","mla":"Lenz, Daniel, et al. “Self-Adjoint Extensions of Bipartite Hamiltonians.” <i>Proceedings of the Edinburgh Mathematical Society</i>, vol. 64, no. 3, Cambridge University Press, 2021, pp. 443–47, doi:<a href=\"https://doi.org/10.1017/S0013091521000080\">10.1017/S0013091521000080</a>."},"date_updated":"2023-08-17T07:12:05Z","abstract":[{"lang":"eng","text":"We compute the deficiency spaces of operators of the form 𝐻𝐴⊗̂ 𝐼+𝐼⊗̂ 𝐻𝐵, for symmetric 𝐻𝐴 and self-adjoint 𝐻𝐵. This enables us to construct self-adjoint extensions (if they exist) by means of von Neumann's theory. The structure of the deficiency spaces for this case was asserted already in Ibort et al. [Boundary dynamics driven entanglement, J. Phys. A: Math. Theor. 47(38) (2014) 385301], but only proven under the restriction of 𝐻𝐵 having discrete, non-degenerate spectrum."}],"publication_identifier":{"issn":["0013-0915"],"eissn":["1464-3839"]},"article_processing_charge":"No","acknowledgement":"M. W. gratefully acknowledges financial support by the German Academic Scholarship Foundation (Studienstiftung des deutschen Volkes). T.W. thanks PAO Gazprom Neft, the Euler International Mathematical Institute in Saint Petersburg and ORISA GmbH for their financial support in the form of scholarships during his Master's and Bachelor's studies respectively. The authors want to thank Mark Malamud for pointing out the reference [1] to them. This work was supported by the Ministry of Science and Higher Education of the Russian Federation, agreement No 075-15-2019-1619.","_id":"9627","language":[{"iso":"eng"}],"publication_status":"published","external_id":{"arxiv":["1912.03670"],"isi":["000721363700003"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"JaMa"}],"doi":"10.1017/S0013091521000080","oa_version":"Published Version","arxiv":1,"isi":1,"year":"2021","type":"journal_article","scopus_import":"1"},{"day":"21","citation":{"chicago":"Yang, Qiutan, Shi-lei Xue, Chii Jou Chan, Markus Rempfler, Dario Vischi, Francisca Maurer-Gutierrez, Takashi Hiiragi, Edouard B Hannezo, and Prisca Liberali. “Cell Fate Coordinates Mechano-Osmotic Forces in Intestinal Crypt Formation.” <i>Nature Cell Biology</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41556-021-00700-2\">https://doi.org/10.1038/s41556-021-00700-2</a>.","ista":"Yang Q, Xue S, Chan CJ, Rempfler M, Vischi D, Maurer-Gutierrez F, Hiiragi T, Hannezo EB, Liberali P. 2021. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. Nature Cell Biology. 23, 733–744.","ama":"Yang Q, Xue S, Chan CJ, et al. Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. <i>Nature Cell Biology</i>. 2021;23:733–744. doi:<a href=\"https://doi.org/10.1038/s41556-021-00700-2\">10.1038/s41556-021-00700-2</a>","mla":"Yang, Qiutan, et al. “Cell Fate Coordinates Mechano-Osmotic Forces in Intestinal Crypt Formation.” <i>Nature Cell Biology</i>, vol. 23, Springer Nature, 2021, pp. 733–744, doi:<a href=\"https://doi.org/10.1038/s41556-021-00700-2\">10.1038/s41556-021-00700-2</a>.","short":"Q. Yang, S. Xue, C.J. Chan, M. Rempfler, D. Vischi, F. Maurer-Gutierrez, T. Hiiragi, E.B. Hannezo, P. Liberali, Nature Cell Biology 23 (2021) 733–744.","apa":"Yang, Q., Xue, S., Chan, C. J., Rempfler, M., Vischi, D., Maurer-Gutierrez, F., … Liberali, P. (2021). Cell fate coordinates mechano-osmotic forces in intestinal crypt formation. <i>Nature Cell Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41556-021-00700-2\">https://doi.org/10.1038/s41556-021-00700-2</a>","ieee":"Q. Yang <i>et al.</i>, “Cell fate coordinates mechano-osmotic forces in intestinal crypt formation,” <i>Nature Cell Biology</i>, vol. 23. Springer Nature, pp. 733–744, 2021."},"date_updated":"2023-08-10T13:57:36Z","volume":23,"article_type":"original","date_created":"2021-07-04T22:01:25Z","date_published":"2021-06-21T00:00:00Z","month":"06","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/2020.05.13.094359"}],"page":"733–744","quality_controlled":"1","publisher":"Springer Nature","publication":"Nature Cell Biology","intvolume":"        23","title":"Cell fate coordinates mechano-osmotic forces in intestinal crypt formation","status":"public","oa":1,"author":[{"last_name":"Yang","first_name":"Qiutan","full_name":"Yang, Qiutan"},{"first_name":"Shi-lei","last_name":"Xue","id":"31D2C804-F248-11E8-B48F-1D18A9856A87","full_name":"Xue, Shi-lei"},{"last_name":"Chan","first_name":"Chii Jou","full_name":"Chan, Chii Jou"},{"full_name":"Rempfler, Markus","first_name":"Markus","last_name":"Rempfler"},{"full_name":"Vischi, Dario","last_name":"Vischi","first_name":"Dario"},{"full_name":"Maurer-Gutierrez, Francisca","first_name":"Francisca","last_name":"Maurer-Gutierrez"},{"full_name":"Hiiragi, Takashi","last_name":"Hiiragi","first_name":"Takashi"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","last_name":"Hannezo","orcid":"0000-0001-6005-1561","first_name":"Edouard B"},{"first_name":"Prisca","last_name":"Liberali","full_name":"Liberali, Prisca"}],"year":"2021","type":"journal_article","isi":1,"scopus_import":"1","doi":"10.1038/s41556-021-00700-2","oa_version":"Preprint","pmid":1,"language":[{"iso":"eng"}],"_id":"9629","publication_status":"published","project":[{"name":"Design Principles of Branching Morphogenesis","_id":"05943252-7A3F-11EA-A408-12923DDC885E","grant_number":"851288","call_identifier":"H2020"},{"_id":"268294B6-B435-11E9-9278-68D0E5697425","grant_number":"P31639","call_identifier":"FWF","name":"Active mechano-chemical description of the cell cytoskeleton"}],"external_id":{"pmid":["34155381"],"isi":["000664016300003"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"EdHa"}],"abstract":[{"lang":"eng","text":"Intestinal organoids derived from single cells undergo complex crypt–villus patterning and morphogenesis. However, the nature and coordination of the underlying forces remains poorly characterized. Here, using light-sheet microscopy and large-scale imaging quantification, we demonstrate that crypt formation coincides with a stark reduction in lumen volume. We develop a 3D biophysical model to computationally screen different mechanical scenarios of crypt morphogenesis. Combining this with live-imaging data and multiple mechanical perturbations, we show that actomyosin-driven crypt apical contraction and villus basal tension work synergistically with lumen volume reduction to drive crypt morphogenesis, and demonstrate the existence of a critical point in differential tensions above which crypt morphology becomes robust to volume changes. Finally, we identified a sodium/glucose cotransporter that is specific to differentiated enterocytes that modulates lumen volume reduction through cell swelling in the villus region. Together, our study uncovers the cellular basis of how cell fate modulates osmotic and actomyosin forces to coordinate robust morphogenesis."}],"ec_funded":1,"publication_identifier":{"eissn":["1476-4679"],"issn":["1465-7392"]},"article_processing_charge":"No","acknowledgement":"We acknowledge the members of the Lennon-Duménil laboratory for sharing the mouse line of Myh9-GFP. We are grateful to the members of the Liberali laboratory and the FMI facilities for their support. We thank E. Tagliavini for IT support; L. Gelman for assistance and training; S. Bichet and A. Bogucki for helping with histology of mouse tissues; H. Kohler for fluorescence-activated cell sorting; G. Q. G. de Medeiros for maintenance of light-sheet microscopy; M. G. Stadler for scRNA-seq analysis; G. Gay for discussions on the 3D vertex model; the members of the Liberali laboratory, C. P. Heisenberg and C. Tsiairis for reading and providing feedback on the manuscript. Funding: Q.Y. is supported by a Postdoc fellowship from Peter und Taul Engelhorn Stiftung (PTES). This work received funding from the European Research Council (ERC) under the EU Horizon 2020 research and Innovation Programme Grant Agreement no. 758617 (to P.L.), the Swiss National Foundation (SNF) (POOP3_157531, to P.L.) and from the ERC under the EU Horizon 2020 Research and Innovation Program Grant Agreements 851288 (to E.H.) and the Austrian Science Fund (FWF) (P31639, to E.H.)."},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"AnHi"}],"publisher":"Institute of Science and Technology Austria","_id":"9636","author":[{"full_name":"Higginbotham, Andrew P","id":"4AD6785A-F248-11E8-B48F-1D18A9856A87","first_name":"Andrew P","orcid":"0000-0003-2607-2363","last_name":"Higginbotham"}],"article_processing_charge":"No","file_date_updated":"2021-07-07T20:37:28Z","oa":1,"status":"public","title":"Data for \"Breakdown of induced p ± ip pairing in a superconductor-semiconductor hybrid\"","date_updated":"2024-02-21T12:36:52Z","citation":{"chicago":"Higginbotham, Andrew P. “Data for ‘Breakdown of Induced p ± Ip Pairing in a Superconductor-Semiconductor Hybrid.’” Institute of Science and Technology Austria, 2021.","ista":"Higginbotham AP. 2021. Data for ‘Breakdown of induced p ± ip pairing in a superconductor-semiconductor hybrid’, Institute of Science and Technology Austria.","ama":"Higginbotham AP. Data for “Breakdown of induced p ± ip pairing in a superconductor-semiconductor hybrid.” 2021.","mla":"Higginbotham, Andrew P. <i>Data for “Breakdown of Induced p ± Ip Pairing in a Superconductor-Semiconductor Hybrid.”</i> Institute of Science and Technology Austria, 2021.","apa":"Higginbotham, A. P. (2021). Data for “Breakdown of induced p ± ip pairing in a superconductor-semiconductor hybrid.” Institute of Science and Technology Austria.","short":"A.P. Higginbotham, (2021).","ieee":"A. P. Higginbotham, “Data for ‘Breakdown of induced p ± ip pairing in a superconductor-semiconductor hybrid.’” Institute of Science and Technology Austria, 2021."},"file":[{"date_created":"2021-07-07T20:37:28Z","file_size":3345244,"creator":"ahigginb","relation":"main_file","file_id":"9637","access_level":"open_access","content_type":"application/zip","success":1,"file_name":"figures_data.zip","date_updated":"2021-07-07T20:37:28Z","checksum":"18e90687ec7bbd75f8bfea4d8293fb30"}],"related_material":{"record":[{"status":"public","id":"10029","relation":"used_in_publication"}]},"type":"research_data","year":"2021","license":"https://creativecommons.org/licenses/by-nc/4.0/","date_created":"2021-07-07T20:43:10Z","date_published":"2021-01-01T00:00:00Z","oa_version":"Submitted Version","has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png"}},{"oa_version":"Published Version","pmid":1,"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1038/s41467-021-24271-w","isi":1,"type":"journal_article","year":"2021","scopus_import":"1","file_date_updated":"2021-07-19T13:02:20Z","publication_identifier":{"eissn":["20411723"]},"acknowledgement":"K.C. acknowledges support from ERC Start grant no. (279307: Graph Games), ERC Consolidator grant no. (863818: ForM-SMart), Austrian Science Fund (FWF) grant no. P23499-N23 and S11407-N23 (RiSE). M.A.N. acknowledges support from Office of Naval Research grant N00014-16-1-2914 and from the John Templeton Foundation.","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Selection and random drift determine the probability that novel mutations fixate in a population. Population structure is known to affect the dynamics of the evolutionary process. Amplifiers of selection are population structures that increase the fixation probability of beneficial mutants compared to well-mixed populations. Over the past 15 years, extensive research has produced remarkable structures called strong amplifiers which guarantee that every beneficial mutation fixates with high probability. But strong amplification has come at the cost of considerably delaying the fixation event, which can slow down the overall rate of evolution. However, the precise relationship between fixation probability and time has remained elusive. Here we characterize the slowdown effect of strong amplification. First, we prove that all strong amplifiers must delay the fixation event at least to some extent. Second, we construct strong amplifiers that delay the fixation event only marginally as compared to the well-mixed populations. Our results thus establish a tight relationship between fixation probability and time: Strong amplification always comes at a cost of a slowdown, but more than a marginal slowdown is not needed."}],"ec_funded":1,"project":[{"name":"Quantitative Graph Games: Theory and Applications","grant_number":"279307","call_identifier":"FP7","_id":"2581B60A-B435-11E9-9278-68D0E5697425"},{"_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","grant_number":"863818","call_identifier":"H2020","name":"Formal Methods for Stochastic Models: Algorithms and Applications"},{"_id":"2584A770-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P 23499-N23","name":"Modern Graph Algorithmic Techniques in Formal Verification"},{"name":"Rigorous Systems Engineering","call_identifier":"FWF","grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425"}],"external_id":{"pmid":["34188036"],"isi":["000671752100003"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","department":[{"_id":"KrCh"}],"language":[{"iso":"eng"}],"_id":"9640","publication_status":"published","ddc":["510"],"date_published":"2021-06-29T00:00:00Z","date_created":"2021-07-11T22:01:15Z","month":"06","has_accepted_license":"1","article_type":"original","volume":12,"citation":{"ama":"Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. Fast and strong amplifiers of natural selection. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-24271-w\">10.1038/s41467-021-24271-w</a>","ista":"Tkadlec J, Pavlogiannis A, Chatterjee K, Nowak MA. 2021. Fast and strong amplifiers of natural selection. Nature Communications. 12(1), 4009.","mla":"Tkadlec, Josef, et al. “Fast and Strong Amplifiers of Natural Selection.” <i>Nature Communications</i>, vol. 12, no. 1, 4009, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-24271-w\">10.1038/s41467-021-24271-w</a>.","chicago":"Tkadlec, Josef, Andreas Pavlogiannis, Krishnendu Chatterjee, and Martin A. Nowak. “Fast and Strong Amplifiers of Natural Selection.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-24271-w\">https://doi.org/10.1038/s41467-021-24271-w</a>.","short":"J. Tkadlec, A. Pavlogiannis, K. Chatterjee, M.A. Nowak, Nature Communications 12 (2021).","apa":"Tkadlec, J., Pavlogiannis, A., Chatterjee, K., &#38; Nowak, M. A. (2021). Fast and strong amplifiers of natural selection. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-24271-w\">https://doi.org/10.1038/s41467-021-24271-w</a>","ieee":"J. Tkadlec, A. Pavlogiannis, K. Chatterjee, and M. A. Nowak, “Fast and strong amplifiers of natural selection,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021."},"day":"29","file":[{"file_name":"2021_NatCoom_Tkadlec.pdf","success":1,"date_updated":"2021-07-19T13:02:20Z","checksum":"5767418926a7f7fb76151de29473dae0","date_created":"2021-07-19T13:02:20Z","creator":"cziletti","relation":"main_file","file_id":"9692","file_size":628992,"access_level":"open_access","content_type":"application/pdf"}],"date_updated":"2025-07-14T09:10:05Z","oa":1,"author":[{"id":"3F24CCC8-F248-11E8-B48F-1D18A9856A87","full_name":"Tkadlec, Josef","orcid":"0000-0002-1097-9684","last_name":"Tkadlec","first_name":"Josef"},{"id":"49704004-F248-11E8-B48F-1D18A9856A87","full_name":"Pavlogiannis, Andreas","orcid":"0000-0002-8943-0722","last_name":"Pavlogiannis","first_name":"Andreas"},{"last_name":"Chatterjee","orcid":"0000-0002-4561-241X","first_name":"Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87","full_name":"Chatterjee, Krishnendu"},{"full_name":"Nowak, Martin A.","last_name":"Nowak","first_name":"Martin A."}],"title":"Fast and strong amplifiers of natural selection","article_number":"4009","status":"public","quality_controlled":"1","publisher":"Springer Nature","publication":"Nature Communications","intvolume":"        12","issue":"1"}]