[{"month":"01","ec_funded":1,"status":"public","publication_identifier":{"issn":["0024-3795"]},"oa":1,"_id":"8373","abstract":[{"lang":"eng","text":"It is well known that special Kubo-Ando operator means admit divergence center interpretations, moreover, they are also mean squared error estimators for certain metrics on positive definite operators. In this paper we give a divergence center interpretation for every symmetric Kubo-Ando mean. This characterization of the symmetric means naturally leads to a definition of weighted and multivariate versions of a large class of symmetric Kubo-Ando means. We study elementary properties of these weighted multivariate means, and note in particular that in the special case of the geometric mean we recover the weighted A#H-mean introduced by Kim, Lawson, and Lim."}],"arxiv":1,"date_updated":"2023-08-04T10:58:14Z","year":"2021","citation":{"apa":"Pitrik, J., &#38; Virosztek, D. (2021). A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means. <i>Linear Algebra and Its Applications</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.laa.2020.09.007\">https://doi.org/10.1016/j.laa.2020.09.007</a>","ista":"Pitrik J, Virosztek D. 2021. A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means. Linear Algebra and its Applications. 609, 203–217.","mla":"Pitrik, József, and Daniel Virosztek. “A Divergence Center Interpretation of General Symmetric Kubo-Ando Means, and Related Weighted Multivariate Operator Means.” <i>Linear Algebra and Its Applications</i>, vol. 609, Elsevier, 2021, pp. 203–17, doi:<a href=\"https://doi.org/10.1016/j.laa.2020.09.007\">10.1016/j.laa.2020.09.007</a>.","chicago":"Pitrik, József, and Daniel Virosztek. “A Divergence Center Interpretation of General Symmetric Kubo-Ando Means, and Related Weighted Multivariate Operator Means.” <i>Linear Algebra and Its Applications</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.laa.2020.09.007\">https://doi.org/10.1016/j.laa.2020.09.007</a>.","ama":"Pitrik J, Virosztek D. A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means. <i>Linear Algebra and its Applications</i>. 2021;609:203-217. doi:<a href=\"https://doi.org/10.1016/j.laa.2020.09.007\">10.1016/j.laa.2020.09.007</a>","ieee":"J. Pitrik and D. Virosztek, “A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means,” <i>Linear Algebra and its Applications</i>, vol. 609. Elsevier, pp. 203–217, 2021.","short":"J. Pitrik, D. Virosztek, Linear Algebra and Its Applications 609 (2021) 203–217."},"intvolume":"       609","main_file_link":[{"url":"https://arxiv.org/abs/2002.11678","open_access":"1"}],"oa_version":"Preprint","date_published":"2021-01-15T00:00:00Z","doi":"10.1016/j.laa.2020.09.007","publication_status":"published","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Elsevier","title":"A divergence center interpretation of general symmetric Kubo-Ando means, and related weighted multivariate operator means","isi":1,"author":[{"full_name":"Pitrik, József","last_name":"Pitrik","first_name":"József"},{"orcid":"0000-0003-1109-5511","first_name":"Daniel","id":"48DB45DA-F248-11E8-B48F-1D18A9856A87","last_name":"Virosztek","full_name":"Virosztek, Daniel"}],"project":[{"_id":"26A455A6-B435-11E9-9278-68D0E5697425","grant_number":"846294","name":"Geometric study of Wasserstein spaces and free probability","call_identifier":"H2020"},{"call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"acknowledgement":"The authors are grateful to Milán Mosonyi for fruitful discussions on the topic, and to the anonymous referee for his/her comments and suggestions.\r\nJ. Pitrik was supported by the Hungarian Academy of Sciences Lendület-Momentum Grant for Quantum Information Theory, No. 96 141, and by Hungarian National Research, Development and Innovation Office (NKFIH) via grants no. K119442, no. K124152, and no. KH129601. D. Virosztek was supported by the ISTFELLOW program of the Institute of Science and Technology Austria (project code IC1027FELL01), by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement No. 846294, and partially supported by the Hungarian National Research, Development and Innovation Office (NKFIH) via grants no. K124152, and no. KH129601.","day":"15","volume":609,"quality_controlled":"1","keyword":["Kubo-Ando mean","weighted multivariate mean","barycenter"],"external_id":{"arxiv":["2002.11678"],"isi":["000581730500011"]},"article_processing_charge":"No","article_type":"original","type":"journal_article","department":[{"_id":"LaEr"}],"language":[{"iso":"eng"}],"publication":"Linear Algebra and its Applications","page":"203-217","date_created":"2020-09-11T08:35:50Z"},{"article_type":"original","article_processing_charge":"No","volume":12,"quality_controlled":"1","external_id":{"isi":["000724450600023"]},"related_material":{"record":[{"status":"public","relation":"research_data","id":"13063"}]},"has_accepted_license":"1","publication":"Nature Communications","date_created":"2020-09-17T10:52:38Z","type":"journal_article","department":[{"_id":"MaRo"}],"language":[{"iso":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Springer Nature","title":"Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits","license":"https://creativecommons.org/licenses/by/4.0/","acknowledgement":"This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria. We would like to thank the participants of the cohort studies, and the Ecole Polytechnique Federal Lausanne (EPFL) SCITAS for their excellent compute resources, their generosity with their time and the kindness of their support. P.M.V. acknowledges funding from the Australian National Health and Medical Research Council (1113400) and the Australian Research Council (FL180100072). L.R. acknowledges funding from the Kjell & Märta Beijer Foundation (Stockholm, Sweden). We also would like to acknowledge Simone Rubinacci, Oliver Delanau, Alexander Terenin, Eleonora Porcu, and Mike Goddard for their useful comments and suggestions.","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"30","author":[{"full_name":"Patxot, Marion","last_name":"Patxot","first_name":"Marion"},{"full_name":"Trejo Banos, Daniel","first_name":"Daniel","last_name":"Trejo Banos"},{"full_name":"Kousathanas, Athanasios","last_name":"Kousathanas","first_name":"Athanasios"},{"last_name":"Orliac","first_name":"Etienne J","full_name":"Orliac, Etienne J"},{"full_name":"Ojavee, Sven E","last_name":"Ojavee","first_name":"Sven E"},{"full_name":"Moser, Gerhard","last_name":"Moser","first_name":"Gerhard"},{"full_name":"Sidorenko, Julia","last_name":"Sidorenko","first_name":"Julia"},{"first_name":"Zoltan","last_name":"Kutalik","full_name":"Kutalik, Zoltan"},{"full_name":"Magi, Reedik","last_name":"Magi","first_name":"Reedik"},{"full_name":"Visscher, Peter M","last_name":"Visscher","first_name":"Peter M"},{"last_name":"Ronnegard","first_name":"Lars","full_name":"Ronnegard, Lars"},{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson","orcid":"0000-0001-8982-8813","first_name":"Matthew Richard"}],"isi":1,"file":[{"date_created":"2021-12-06T07:47:11Z","date_updated":"2021-12-06T07:47:11Z","file_name":"2021_NatComm_Paxtot.pdf","access_level":"open_access","creator":"cchlebak","file_id":"10419","checksum":"384681be17aff902c149a48f52d13d4f","file_size":6519771,"success":1,"content_type":"application/pdf","relation":"main_file"}],"scopus_import":"1","file_date_updated":"2021-12-06T07:47:11Z","ddc":["610"],"intvolume":"        12","citation":{"chicago":"Patxot, Marion, Daniel Trejo Banos, Athanasios Kousathanas, Etienne J Orliac, Sven E Ojavee, Gerhard Moser, Julia Sidorenko, et al. “Probabilistic Inference of the Genetic Architecture Underlying Functional Enrichment of Complex Traits.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-27258-9\">https://doi.org/10.1038/s41467-021-27258-9</a>.","apa":"Patxot, M., Trejo Banos, D., Kousathanas, A., Orliac, E. J., Ojavee, S. E., Moser, G., … Robinson, M. R. (2021). Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-27258-9\">https://doi.org/10.1038/s41467-021-27258-9</a>","ista":"Patxot M, Trejo Banos D, Kousathanas A, Orliac EJ, Ojavee SE, Moser G, Sidorenko J, Kutalik Z, Magi R, Visscher PM, Ronnegard L, Robinson MR. 2021. Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. Nature Communications. 12(1), 6972.","mla":"Patxot, Marion, et al. “Probabilistic Inference of the Genetic Architecture Underlying Functional Enrichment of Complex Traits.” <i>Nature Communications</i>, vol. 12, no. 1, 6972, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-27258-9\">10.1038/s41467-021-27258-9</a>.","ama":"Patxot M, Trejo Banos D, Kousathanas A, et al. Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-27258-9\">10.1038/s41467-021-27258-9</a>","ieee":"M. Patxot <i>et al.</i>, “Probabilistic inference of the genetic architecture underlying functional enrichment of complex traits,” <i>Nature Communications</i>, vol. 12, no. 1. Springer Nature, 2021.","short":"M. Patxot, D. Trejo Banos, A. Kousathanas, E.J. Orliac, S.E. Ojavee, G. Moser, J. Sidorenko, Z. Kutalik, R. Magi, P.M. Visscher, L. Ronnegard, M.R. Robinson, Nature Communications 12 (2021)."},"doi":"10.1038/s41467-021-27258-9","publication_status":"published","oa_version":"Published Version","date_published":"2021-11-30T00:00:00Z","status":"public","oa":1,"publication_identifier":{"eissn":["2041-1723"]},"month":"11","abstract":[{"lang":"eng","text":"We develop a Bayesian model (BayesRR-RC) that provides robust SNP-heritability estimation, an alternative to marker discovery, and accurate genomic prediction, taking 22 seconds per iteration to estimate 8.4 million SNP-effects and 78 SNP-heritability parameters in the UK Biobank. We find that only ≤10% of the genetic variation captured for height, body mass index, cardiovascular disease, and type 2 diabetes is attributable to proximal regulatory regions within 10kb upstream of genes, while 12-25% is attributed to coding regions, 32–44% to introns, and 22-28% to distal 10-500kb upstream regions. Up to 24% of all cis and coding regions of each chromosome are associated with each trait, with over 3,100 independent exonic and intronic regions and over 5,400 independent regulatory regions having ≥95% probability of contributing ≥0.001% to the genetic variance of these four traits. Our open-source software (GMRM) provides a scalable alternative to current approaches for biobank data."}],"issue":"1","date_updated":"2023-09-26T10:36:14Z","year":"2021","article_number":"6972","_id":"8429"},{"article_processing_charge":"No","quality_controlled":"1","volume":12,"external_id":{"isi":["000642509600006"]},"related_material":{"link":[{"url":"https://ist.ac.at/en/news/predicting-the-onset-of-diseases/","relation":"press_release","description":"News on IST Homepage"}]},"has_accepted_license":"1","publication":"Nature Communications","date_created":"2020-09-17T10:53:00Z","type":"journal_article","department":[{"_id":"MaRo"}],"language":[{"iso":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Nature Research","title":"Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis","acknowledgement":"This project was funded by an SNSF Eccellenza Grant to MRR (PCEGP3-181181), and by core funding from the Institute of Science and Technology Austria and the University of Lausanne; the work of KF was supported by the grant PUT1665 by the Estonian Research Council. We would like to thank Mike Goddard for comments which greatly improved the work, the participants of the cohort studies, and the Ecole Polytechnique Federal Lausanne (EPFL) SCITAS for their excellent compute resources, their generosity with their time and the kindness of their support.","day":"20","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"author":[{"full_name":"Ojavee, Sven E","first_name":"Sven E","last_name":"Ojavee"},{"full_name":"Kousathanas, Athanasios","last_name":"Kousathanas","first_name":"Athanasios"},{"first_name":"Daniel","last_name":"Trejo Banos","full_name":"Trejo Banos, Daniel"},{"first_name":"Etienne J","last_name":"Orliac","full_name":"Orliac, Etienne J"},{"first_name":"Marion","last_name":"Patxot","full_name":"Patxot, Marion"},{"full_name":"Lall, Kristi","first_name":"Kristi","last_name":"Lall"},{"full_name":"Magi, Reedik","last_name":"Magi","first_name":"Reedik"},{"full_name":"Fischer, Krista","first_name":"Krista","last_name":"Fischer"},{"full_name":"Kutalik, Zoltan","last_name":"Kutalik","first_name":"Zoltan"},{"full_name":"Robinson, Matthew Richard","orcid":"0000-0001-8982-8813","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson"}],"isi":1,"project":[{"_id":"9B8D11D6-BA93-11EA-9121-9846C619BF3A","grant_number":"PCEGP3_181181","name":"Improving estimation and prediction of common complex disease risk"}],"file":[{"file_name":"2021_nature_communications_Ojavee.pdf","date_updated":"2021-05-04T15:07:50Z","date_created":"2021-05-04T15:07:50Z","creator":"kschuh","checksum":"eca8b9ae713835c5b785211dd08d8a2e","file_id":"9372","access_level":"open_access","relation":"main_file","content_type":"application/pdf","success":1,"file_size":6474239}],"file_date_updated":"2021-05-04T15:07:50Z","scopus_import":"1","ddc":["570"],"intvolume":"        12","citation":{"short":"S.E. Ojavee, A. Kousathanas, D. Trejo Banos, E.J. Orliac, M. Patxot, K. Lall, R. Magi, K. Fischer, Z. Kutalik, M.R. Robinson, Nature Communications 12 (2021).","ama":"Ojavee SE, Kousathanas A, Trejo Banos D, et al. Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. <i>Nature Communications</i>. 2021;12(1). doi:<a href=\"https://doi.org/10.1038/s41467-021-22538-w\">10.1038/s41467-021-22538-w</a>","ieee":"S. E. Ojavee <i>et al.</i>, “Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis,” <i>Nature Communications</i>, vol. 12, no. 1. Nature Research, 2021.","chicago":"Ojavee, Sven E, Athanasios Kousathanas, Daniel Trejo Banos, Etienne J Orliac, Marion Patxot, Kristi Lall, Reedik Magi, Krista Fischer, Zoltan Kutalik, and Matthew Richard Robinson. “Genomic Architecture and Prediction of Censored Time-to-Event Phenotypes with a Bayesian Genome-Wide Analysis.” <i>Nature Communications</i>. Nature Research, 2021. <a href=\"https://doi.org/10.1038/s41467-021-22538-w\">https://doi.org/10.1038/s41467-021-22538-w</a>.","ista":"Ojavee SE, Kousathanas A, Trejo Banos D, Orliac EJ, Patxot M, Lall K, Magi R, Fischer K, Kutalik Z, Robinson MR. 2021. Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. Nature Communications. 12(1), 2337.","apa":"Ojavee, S. E., Kousathanas, A., Trejo Banos, D., Orliac, E. J., Patxot, M., Lall, K., … Robinson, M. R. (2021). Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. <i>Nature Communications</i>. Nature Research. <a href=\"https://doi.org/10.1038/s41467-021-22538-w\">https://doi.org/10.1038/s41467-021-22538-w</a>","mla":"Ojavee, Sven E., et al. “Genomic Architecture and Prediction of Censored Time-to-Event Phenotypes with a Bayesian Genome-Wide Analysis.” <i>Nature Communications</i>, vol. 12, no. 1, 2337, Nature Research, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-22538-w\">10.1038/s41467-021-22538-w</a>."},"doi":"10.1038/s41467-021-22538-w","publication_status":"published","oa_version":"Published Version","date_published":"2021-04-20T00:00:00Z","status":"public","publication_identifier":{"eissn":["20411723"]},"oa":1,"month":"04","issue":"1","abstract":[{"lang":"eng","text":"While recent advancements in computation and modelling have improved the analysis of complex traits, our understanding of the genetic basis of the time at symptom onset remains limited. Here, we develop a Bayesian approach (BayesW) that provides probabilistic inference of the genetic architecture of age-at-onset phenotypes in a sampling scheme that facilitates biobank-scale time-to-event analyses. We show in extensive simulation work the benefits BayesW provides in terms of number of discoveries, model performance and genomic prediction. In the UK Biobank, we find many thousands of common genomic regions underlying the age-at-onset of high blood pressure (HBP), cardiac disease (CAD), and type-2 diabetes (T2D), and for the genetic basis of onset reflecting the underlying genetic liability to disease. Age-at-menopause and age-at-menarche are also highly polygenic, but with higher variance contributed by low frequency variants. Genomic prediction into the Estonian Biobank data shows that BayesW gives higher prediction accuracy than other approaches."}],"date_updated":"2023-08-04T11:00:17Z","year":"2021","article_number":"2337","_id":"8430"},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/2020.06.14.151258"}],"scopus_import":"1","intvolume":"       109","citation":{"mla":"Takeo, Yukari H., et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” <i>Neuron</i>, vol. 109, no. 4, Elsevier, 2021, p. P629–644.E8, doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.11.028\">10.1016/j.neuron.2020.11.028</a>.","ista":"Takeo YH, Shuster SA, Jiang L, Hu M, Luginbuhl DJ, Rülicke T, Contreras X, Hippenmeyer S, Wagner MJ, Ganguli S, Luo L. 2021. GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. Neuron. 109(4), P629–644.E8.","apa":"Takeo, Y. H., Shuster, S. A., Jiang, L., Hu, M., Luginbuhl, D. J., Rülicke, T., … Luo, L. (2021). GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2020.11.028\">https://doi.org/10.1016/j.neuron.2020.11.028</a>","chicago":"Takeo, Yukari H., S. Andrew Shuster, Linnie Jiang, Miley Hu, David J. Luginbuhl, Thomas Rülicke, Ximena Contreras, et al. “GluD2- and Cbln1-Mediated Competitive Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells.” <i>Neuron</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.neuron.2020.11.028\">https://doi.org/10.1016/j.neuron.2020.11.028</a>.","short":"Y.H. Takeo, S.A. Shuster, L. Jiang, M. Hu, D.J. Luginbuhl, T. Rülicke, X. Contreras, S. Hippenmeyer, M.J. Wagner, S. Ganguli, L. Luo, Neuron 109 (2021) P629–644.E8.","ieee":"Y. H. Takeo <i>et al.</i>, “GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells,” <i>Neuron</i>, vol. 109, no. 4. Elsevier, p. P629–644.E8, 2021.","ama":"Takeo YH, Shuster SA, Jiang L, et al. GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells. <i>Neuron</i>. 2021;109(4):P629-644.E8. doi:<a href=\"https://doi.org/10.1016/j.neuron.2020.11.028\">10.1016/j.neuron.2020.11.028</a>"},"doi":"10.1016/j.neuron.2020.11.028","publication_status":"published","date_published":"2021-02-17T00:00:00Z","oa_version":"Preprint","oa":1,"publication_identifier":{"eissn":["1097-4199"]},"status":"public","ec_funded":1,"month":"02","year":"2021","abstract":[{"text":"The synaptotrophic hypothesis posits that synapse formation stabilizes dendritic branches, yet this hypothesis has not been causally tested in vivo in the mammalian brain. Presynaptic ligand cerebellin-1 (Cbln1) and postsynaptic receptor GluD2 mediate synaptogenesis between granule cells and Purkinje cells in the molecular layer of the cerebellar cortex. Here we show that sparse but not global knockout of GluD2 causes under-elaboration of Purkinje cell dendrites in the deep molecular layer and overelaboration in the superficial molecular layer. Developmental, overexpression, structure-function, and genetic epistasis analyses indicate that dendrite morphogenesis defects result from competitive synaptogenesis in a Cbln1/GluD2-dependent manner. A generative model of dendritic growth based on competitive synaptogenesis largely recapitulates GluD2 sparse and global knockout phenotypes. Our results support the synaptotrophic hypothesis at initial stages of dendrite development, suggest a second mode in which cumulative synapse formation inhibits further dendrite growth, and highlight the importance of competition in dendrite morphogenesis.","lang":"eng"}],"issue":"4","date_updated":"2024-03-06T12:12:48Z","_id":"8544","article_processing_charge":"No","article_type":"original","quality_controlled":"1","volume":109,"publication":"Neuron","page":"P629-644.E8","date_created":"2020-09-21T11:59:47Z","department":[{"_id":"SiHi"}],"language":[{"iso":"eng"}],"type":"journal_article","title":"GluD2- and Cbln1-mediated competitive synaptogenesis shapes the dendritic arbors of cerebellar Purkinje cells","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Elsevier","day":"17","acknowledgement":"We thank M. Mishina for GluD2fl frozen embryos, T.C. Südhof and J.I. Morgan for Cbln1fl mice, L. Anderson for help in generating the MADM alleles, W. Joo for a previously unpublished construct, M. Yuzaki, K. Shen, J. Ding, and members of the Luo lab, including J.M. Kebschull, H. Li, J. Li, T. Li, C.M. McLaughlin, D. Pederick, J. Ren, D.C. Wang and C. Xu for discussions and critiques of the manuscript, and M. Yuzaki for supporting Y.H.T. during the final phase of this project. Y.H.T. was supported by a JSPS fellowship; S.A.S. was supported by a Stanford Graduate Fellowship and an NSF Predoctoral Fellowship; L.J. is supported by a Stanford Graduate Fellowship and an NSF Predoctoral Fellowship; M.J.W. is supported by a Burroughs Wellcome Fund CASI Award. This work was supported by an NIH grant (R01-NS050538) to L.L.; the European Research Council (ERC) under the European Union's Horizon 2020 research and innovations programme (No. 725780 LinPro) to S.H.; and Simons and James S. McDonnell Foundations and an NSF CAREER award to S.G.; L.L. is an HHMI investigator.","author":[{"first_name":"Yukari H.","last_name":"Takeo","full_name":"Takeo, Yukari H."},{"full_name":"Shuster, S. Andrew","last_name":"Shuster","first_name":"S. Andrew"},{"last_name":"Jiang","first_name":"Linnie","full_name":"Jiang, Linnie"},{"first_name":"Miley","last_name":"Hu","full_name":"Hu, Miley"},{"full_name":"Luginbuhl, David J.","last_name":"Luginbuhl","first_name":"David J."},{"full_name":"Rülicke, Thomas","first_name":"Thomas","last_name":"Rülicke"},{"id":"475990FE-F248-11E8-B48F-1D18A9856A87","last_name":"Contreras","first_name":"Ximena","full_name":"Contreras, Ximena"},{"full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer"},{"full_name":"Wagner, Mark J.","last_name":"Wagner","first_name":"Mark J."},{"first_name":"Surya","last_name":"Ganguli","full_name":"Ganguli, Surya"},{"last_name":"Luo","first_name":"Liqun","full_name":"Luo, Liqun"}],"project":[{"_id":"260018B0-B435-11E9-9278-68D0E5697425","grant_number":"725780","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020"}]},{"article_number":"109208","_id":"8546","date_updated":"2023-08-04T11:00:48Z","abstract":[{"lang":"eng","text":"Brain neurons arise from relatively few progenitors generating an enormous diversity of neuronal types. Nonetheless, a cardinal feature of mammalian brain neurogenesis is thought to be that excitatory and inhibitory neurons derive from separate, spatially segregated progenitors. Whether bi-potential progenitors with an intrinsic capacity to generate both lineages exist and how such a fate decision may be regulated are unknown. Using cerebellar development as a model, we discover that individual progenitors can give rise to both inhibitory and excitatory lineages. Gradations of Notch activity determine the fates of the progenitors and their daughters. Daughters with the highest levels of Notch activity retain the progenitor fate, while intermediate levels of Notch activity generate inhibitory neurons, and daughters with very low levels of Notch signaling adopt the excitatory fate. Therefore, Notch-mediated binary cell fate choice is a mechanism for regulating the ratio of excitatory to inhibitory neurons from common progenitors."}],"issue":"10","year":"2021","month":"06","ec_funded":1,"status":"public","oa":1,"publication_identifier":{"eissn":[" 22111247"]},"oa_version":"Published Version","date_published":"2021-06-08T00:00:00Z","publication_status":"published","doi":"10.1016/j.celrep.2021.109208","intvolume":"        35","citation":{"ieee":"T. Zhang <i>et al.</i>, “Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum,” <i>Cell Reports</i>, vol. 35, no. 10. Elsevier, 2021.","ama":"Zhang T, Liu T, Mora N, et al. Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum. <i>Cell Reports</i>. 2021;35(10). doi:<a href=\"https://doi.org/10.1016/j.celrep.2021.109208\">10.1016/j.celrep.2021.109208</a>","short":"T. Zhang, T. Liu, N. Mora, J. Guegan, M. Bertrand, X. Contreras, A.H. Hansen, C. Streicher, M. Anderle, N. Danda, L. Tiberi, S. Hippenmeyer, B.A. Hassan, Cell Reports 35 (2021).","chicago":"Zhang, Tingting, Tengyuan Liu, Natalia Mora, Justine Guegan, Mathilde Bertrand, Ximena Contreras, Andi H Hansen, et al. “Generation of Excitatory and Inhibitory Neurons from Common Progenitors via Notch Signaling in the Cerebellum.” <i>Cell Reports</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.celrep.2021.109208\">https://doi.org/10.1016/j.celrep.2021.109208</a>.","apa":"Zhang, T., Liu, T., Mora, N., Guegan, J., Bertrand, M., Contreras, X., … Hassan, B. A. (2021). Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum. <i>Cell Reports</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.celrep.2021.109208\">https://doi.org/10.1016/j.celrep.2021.109208</a>","ista":"Zhang T, Liu T, Mora N, Guegan J, Bertrand M, Contreras X, Hansen AH, Streicher C, Anderle M, Danda N, Tiberi L, Hippenmeyer S, Hassan BA. 2021. Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum. Cell Reports. 35(10), 109208.","mla":"Zhang, Tingting, et al. “Generation of Excitatory and Inhibitory Neurons from Common Progenitors via Notch Signaling in the Cerebellum.” <i>Cell Reports</i>, vol. 35, no. 10, 109208, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.celrep.2021.109208\">10.1016/j.celrep.2021.109208</a>."},"scopus_import":"1","file_date_updated":"2021-06-15T14:01:35Z","ddc":["570"],"project":[{"call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","_id":"260018B0-B435-11E9-9278-68D0E5697425"},{"name":"Molecular Mechanisms of Radial Neuronal Migration","grant_number":"24812","_id":"2625A13E-B435-11E9-9278-68D0E5697425"}],"author":[{"last_name":"Zhang","first_name":"Tingting","full_name":"Zhang, Tingting"},{"last_name":"Liu","first_name":"Tengyuan","full_name":"Liu, Tengyuan"},{"last_name":"Mora","first_name":"Natalia","full_name":"Mora, Natalia"},{"full_name":"Guegan, Justine","first_name":"Justine","last_name":"Guegan"},{"first_name":"Mathilde","last_name":"Bertrand","full_name":"Bertrand, Mathilde"},{"first_name":"Ximena","last_name":"Contreras","id":"475990FE-F248-11E8-B48F-1D18A9856A87","full_name":"Contreras, Ximena"},{"last_name":"Hansen","id":"38853E16-F248-11E8-B48F-1D18A9856A87","first_name":"Andi H","full_name":"Hansen, Andi H"},{"full_name":"Streicher, Carmen","first_name":"Carmen","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","last_name":"Streicher"},{"full_name":"Anderle, Marica","last_name":"Anderle","first_name":"Marica"},{"last_name":"Danda","first_name":"Natasha","full_name":"Danda, Natasha"},{"full_name":"Tiberi, Luca","last_name":"Tiberi","first_name":"Luca"},{"full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","first_name":"Simon"},{"first_name":"Bassem A.","last_name":"Hassan","full_name":"Hassan, Bassem A."}],"isi":1,"file":[{"date_created":"2021-06-15T14:01:35Z","file_name":"2021_CellReports_Zhang.pdf","date_updated":"2021-06-15T14:01:35Z","access_level":"open_access","creator":"cziletti","file_id":"9554","checksum":"7def3d42ebc8f5675efb6f38819e3e2e","success":1,"file_size":8900385,"relation":"main_file","content_type":"application/pdf"}],"acknowledgement":"This work was supported by the program “Investissements d’avenir” ANR-10-IAIHU-06 , ICM , a Sorbonne Université Emergence grant, an Allen Distinguished Investigator Award , and the Roger De Spoelberch Foundation Prize (to B.A.H.); Armenise-Harvard Foundation , AIRC , and CARITRO (to L.T.); and the European Research Council under the European Union’s Horizon 2020 research and innovation programme grant agreement no. 725780 LinPro (to S.H.). T.Z. and T.L. were supported by doctoral fellowships from the China Scholarship Council and A.H.H. by a doctoral DOC fellowship of the Austrian Academy of Sciences ( 24812 ). All animal work was conducted at the PHENO-ICMice facility. The Core is supported by 2 “Investissements d’avenir” (ANR-10- IAIHU-06 and ANR-11-INBS-0011-NeurATRIS) and the “Fondation pour la Recherche Médicale.” Light microscopy work was carried out at ICM’s imaging core facility, ICM.Quant, and analysis of scRNA-seq data was carried out at ICM’s bioinformatics core facility, iCONICS. We thank Paulina Ejsmont, Natalia Danda, and Nathalie De Geest for technical support. We are grateful to Dr. Shahragim TAJBAKHSH for providing R26Rstop-NICD-nGFP transgenic mice, Dr. Bart De Strooper for Psn1-deficient mice, Dr. Jean-Christophe Marine for Gt(ROSA)26SortdTom reporter mice, and Dr. Martinez Barbera for Sox2CreERT2 mice. We also give thanks to Dr. Mikio Hoshino for providing Atoh1 and Ptf1a antibodies. B.A.H. is an Einstein Visiting Fellow of the Berlin Institute of Health .","pmid":1,"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"day":"08","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","publisher":"Elsevier","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"SiHi"}],"has_accepted_license":"1","date_created":"2020-09-21T12:00:48Z","publication":"Cell Reports","external_id":{"isi":["000659894300001"],"pmid":["34107249 "]},"volume":35,"quality_controlled":"1","related_material":{"link":[{"url":"https://doi.org/10.1101/2020.03.18.997205","relation":"earlier_version"}]},"article_type":"original","article_processing_charge":"No"},{"ec_funded":1,"month":"01","publication_identifier":{"issn":["0028646X"],"eissn":["14698137"]},"oa":1,"status":"public","_id":"8582","acknowledged_ssus":[{"_id":"Bio"}],"year":"2021","date_updated":"2023-08-04T11:01:21Z","abstract":[{"lang":"eng","text":"Cell and tissue polarization is fundamental for plant growth and morphogenesis. The polar, cellular localization of Arabidopsis PIN‐FORMED (PIN) proteins is crucial for their function in directional auxin transport. The clustering of PIN polar cargoes within the plasma membrane has been proposed to be important for the maintenance of their polar distribution. However, the more detailed features of PIN clusters and the cellular requirements of cargo clustering remain unclear.\r\nHere, we characterized PIN clusters in detail by means of multiple advanced microscopy and quantification methods, such as 3D quantitative imaging or freeze‐fracture replica labeling. The size and aggregation types of PIN clusters were determined by electron microscopy at the nanometer level at different polar domains and at different developmental stages, revealing a strong preference for clustering at the polar domains.\r\nPharmacological and genetic studies revealed that PIN clusters depend on phosphoinositol pathways, cytoskeletal structures and specific cell‐wall components as well as connections between the cell wall and the plasma membrane.\r\nThis study identifies the role of different cellular processes and structures in polar cargo clustering and provides initial mechanistic insight into the maintenance of polarity in plants and other systems."}],"issue":"1","citation":{"ieee":"H. Li <i>et al.</i>, “Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana,” <i>New Phytologist</i>, vol. 229, no. 1. Wiley, pp. 351–369, 2021.","ama":"Li H, von Wangenheim D, Zhang X, et al. Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana. <i>New Phytologist</i>. 2021;229(1):351-369. doi:<a href=\"https://doi.org/10.1111/nph.16887\">10.1111/nph.16887</a>","short":"H. Li, D. von Wangenheim, X. Zhang, S. Tan, N. Darwish-Miranda, S. Naramoto, K.T. Wabnik, R. de Rycke, W. Kaufmann, D.J. Gütl, R. Tejos, P. Grones, M. Ke, X. Chen, J. Dettmer, J. Friml, New Phytologist 229 (2021) 351–369.","chicago":"Li, Hongjiang, Daniel von Wangenheim, Xixi Zhang, Shutang Tan, Nasser Darwish-Miranda, Satoshi Naramoto, Krzysztof T Wabnik, et al. “Cellular Requirements for PIN Polar Cargo Clustering in Arabidopsis Thaliana.” <i>New Phytologist</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/nph.16887\">https://doi.org/10.1111/nph.16887</a>.","ista":"Li H, von Wangenheim D, Zhang X, Tan S, Darwish-Miranda N, Naramoto S, Wabnik KT, de Rycke R, Kaufmann W, Gütl DJ, Tejos R, Grones P, Ke M, Chen X, Dettmer J, Friml J. 2021. Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana. New Phytologist. 229(1), 351–369.","apa":"Li, H., von Wangenheim, D., Zhang, X., Tan, S., Darwish-Miranda, N., Naramoto, S., … Friml, J. (2021). Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana. <i>New Phytologist</i>. Wiley. <a href=\"https://doi.org/10.1111/nph.16887\">https://doi.org/10.1111/nph.16887</a>","mla":"Li, Hongjiang, et al. “Cellular Requirements for PIN Polar Cargo Clustering in Arabidopsis Thaliana.” <i>New Phytologist</i>, vol. 229, no. 1, Wiley, 2021, pp. 351–69, doi:<a href=\"https://doi.org/10.1111/nph.16887\">10.1111/nph.16887</a>."},"intvolume":"       229","ddc":["580"],"file_date_updated":"2021-02-04T09:44:17Z","scopus_import":"1","date_published":"2021-01-01T00:00:00Z","oa_version":"Published Version","publication_status":"published","doi":"10.1111/nph.16887","title":"Cellular requirements for PIN polar cargo clustering in Arabidopsis thaliana","publisher":"Wiley","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file":[{"file_size":4061962,"success":1,"content_type":"application/pdf","relation":"main_file","date_created":"2021-02-04T09:44:17Z","date_updated":"2021-02-04T09:44:17Z","file_name":"2021_NewPhytologist_Li.pdf","access_level":"open_access","checksum":"b45621607b4cab97eeb1605ab58e896e","creator":"dernst","file_id":"9084"}],"project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425"},{"grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"}],"author":[{"full_name":"Li, Hongjiang","last_name":"Li","id":"33CA54A6-F248-11E8-B48F-1D18A9856A87","first_name":"Hongjiang","orcid":"0000-0001-5039-9660"},{"full_name":"von Wangenheim, Daniel","id":"49E91952-F248-11E8-B48F-1D18A9856A87","last_name":"von Wangenheim","orcid":"0000-0002-6862-1247","first_name":"Daniel"},{"full_name":"Zhang, Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A","last_name":"Zhang","first_name":"Xixi","orcid":"0000-0001-7048-4627"},{"orcid":"0000-0002-0471-8285","first_name":"Shutang","last_name":"Tan","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","full_name":"Tan, Shutang"},{"first_name":"Nasser","orcid":"0000-0002-8821-8236","id":"39CD9926-F248-11E8-B48F-1D18A9856A87","last_name":"Darwish-Miranda","full_name":"Darwish-Miranda, Nasser"},{"last_name":"Naramoto","first_name":"Satoshi","full_name":"Naramoto, Satoshi"},{"full_name":"Wabnik, Krzysztof T","last_name":"Wabnik","id":"4DE369A4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7263-0560","first_name":"Krzysztof T"},{"full_name":"de Rycke, Riet","first_name":"Riet","last_name":"de Rycke"},{"id":"3F99E422-F248-11E8-B48F-1D18A9856A87","last_name":"Kaufmann","first_name":"Walter","orcid":"0000-0001-9735-5315","full_name":"Kaufmann, Walter"},{"full_name":"Gütl, Daniel J","first_name":"Daniel J","id":"381929CE-F248-11E8-B48F-1D18A9856A87","last_name":"Gütl"},{"full_name":"Tejos, Ricardo","first_name":"Ricardo","last_name":"Tejos"},{"full_name":"Grones, Peter","id":"399876EC-F248-11E8-B48F-1D18A9856A87","last_name":"Grones","first_name":"Peter"},{"first_name":"Meiyu","last_name":"Ke","full_name":"Ke, Meiyu"},{"full_name":"Chen, Xu","first_name":"Xu","id":"4E5ADCAA-F248-11E8-B48F-1D18A9856A87","last_name":"Chen"},{"full_name":"Dettmer, Jan","last_name":"Dettmer","first_name":"Jan"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří","full_name":"Friml, Jiří"}],"isi":1,"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"01","acknowledgement":"We thank Dr Ingo Heilmann (Martin‐Luther‐University Halle‐Wittenberg) for the XVE>>PIP5K1‐YFP line, Dr Brad Day (Michigan State University) for the ndr1‐1 mutant and the complementation lines, and Dr Patricia C. Zambryski (University of California, Berkeley) for the 35S::P30‐GFP line, the Bioimaging team (IST Austria) for assistance with imaging, group members for discussions, Martine De Cock for help in preparing the manuscript and Nataliia Gnyliukh for critical reading and revision of the manuscript. This project received funding from the European Research Council (ERC) under the European Union's Horizon 2020 research and innovation program (grant agreement No. 742985) and Comisión Nacional de Investigación Científica y Tecnológica (Project CONICYT‐PAI 82130047). DvW received funding from the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007‐2013) under REA grant agreement no. 291734.","external_id":{"isi":["000570187900001"]},"volume":229,"quality_controlled":"1","article_type":"original","article_processing_charge":"Yes (via OA deal)","language":[{"iso":"eng"}],"department":[{"_id":"JiFr"},{"_id":"EM-Fac"},{"_id":"Bio"},{"_id":"EvBe"}],"type":"journal_article","page":"351-369","date_created":"2020-09-28T08:59:28Z","publication":"New Phytologist","has_accepted_license":"1"},{"tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"01","file":[{"relation":"main_file","content_type":"application/pdf","success":1,"file_size":497032,"file_id":"8612","checksum":"611ae28d6055e1e298d53a57beb05ef4","creator":"dernst","access_level":"open_access","file_name":"2020_ProbTheory_Cipolloni.pdf","date_updated":"2020-10-05T14:53:40Z","date_created":"2020-10-05T14:53:40Z"}],"isi":1,"author":[{"id":"42198EFA-F248-11E8-B48F-1D18A9856A87","last_name":"Cipolloni","orcid":"0000-0002-4901-7992","first_name":"Giorgio","full_name":"Cipolloni, Giorgio"},{"orcid":"0000-0001-5366-9603","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","last_name":"Erdös","full_name":"Erdös, László"},{"id":"408ED176-F248-11E8-B48F-1D18A9856A87","last_name":"Schröder","orcid":"0000-0002-2904-1856","first_name":"Dominik J","full_name":"Schröder, Dominik J"}],"project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"},{"grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7"},{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020"}],"title":"Edge universality for non-Hermitian random matrices","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publisher":"Springer Nature","publication":"Probability Theory and Related Fields","date_created":"2020-10-04T22:01:37Z","has_accepted_license":"1","department":[{"_id":"LaEr"}],"language":[{"iso":"eng"}],"type":"journal_article","article_processing_charge":"Yes (via OA deal)","article_type":"original","quality_controlled":"1","external_id":{"isi":["000572724600002"],"arxiv":["1908.00969"]},"year":"2021","arxiv":1,"abstract":[{"lang":"eng","text":"We consider large non-Hermitian real or complex random matrices X with independent, identically distributed centred entries. We prove that their local eigenvalue statistics near the spectral edge, the unit circle, coincide with those of the Ginibre ensemble, i.e. when the matrix elements of X are Gaussian. This result is the non-Hermitian counterpart of the universality of the Tracy–Widom distribution at the spectral edges of the Wigner ensemble."}],"date_updated":"2024-03-07T15:07:53Z","_id":"8601","oa":1,"publication_identifier":{"eissn":["14322064"],"issn":["01788051"]},"status":"public","ec_funded":1,"month":"02","doi":"10.1007/s00440-020-01003-7","publication_status":"published","date_published":"2021-02-01T00:00:00Z","oa_version":"Published Version","ddc":["510"],"file_date_updated":"2020-10-05T14:53:40Z","scopus_import":"1","citation":{"ama":"Cipolloni G, Erdös L, Schröder DJ. Edge universality for non-Hermitian random matrices. <i>Probability Theory and Related Fields</i>. 2021. doi:<a href=\"https://doi.org/10.1007/s00440-020-01003-7\">10.1007/s00440-020-01003-7</a>","ieee":"G. Cipolloni, L. Erdös, and D. J. Schröder, “Edge universality for non-Hermitian random matrices,” <i>Probability Theory and Related Fields</i>. Springer Nature, 2021.","short":"G. Cipolloni, L. Erdös, D.J. Schröder, Probability Theory and Related Fields (2021).","chicago":"Cipolloni, Giorgio, László Erdös, and Dominik J Schröder. “Edge Universality for Non-Hermitian Random Matrices.” <i>Probability Theory and Related Fields</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1007/s00440-020-01003-7\">https://doi.org/10.1007/s00440-020-01003-7</a>.","ista":"Cipolloni G, Erdös L, Schröder DJ. 2021. Edge universality for non-Hermitian random matrices. Probability Theory and Related Fields.","mla":"Cipolloni, Giorgio, et al. “Edge Universality for Non-Hermitian Random Matrices.” <i>Probability Theory and Related Fields</i>, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1007/s00440-020-01003-7\">10.1007/s00440-020-01003-7</a>.","apa":"Cipolloni, G., Erdös, L., &#38; Schröder, D. J. (2021). Edge universality for non-Hermitian random matrices. <i>Probability Theory and Related Fields</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00440-020-01003-7\">https://doi.org/10.1007/s00440-020-01003-7</a>"}},{"_id":"8602","date_updated":"2023-08-04T11:02:41Z","abstract":[{"lang":"eng","text":"Collective cell migration offers a rich field of study for non-equilibrium physics and cellular biology, revealing phenomena such as glassy dynamics, pattern formation and active turbulence. However, how mechanical and chemical signalling are integrated at the cellular level to give rise to such collective behaviours remains unclear. We address this by focusing on the highly conserved phenomenon of spatiotemporal waves of density and extracellular signal-regulated kinase (ERK) activation, which appear both in vitro and in vivo during collective cell migration and wound healing. First, we propose a biophysical theory, backed by mechanical and optogenetic perturbation experiments, showing that patterns can be quantitatively explained by a mechanochemical coupling between active cellular tensions and the mechanosensitive ERK pathway. Next, we demonstrate how this biophysical mechanism can robustly induce long-ranged order and migration in a desired orientation, and we determine the theoretically optimal wavelength and period for inducing maximal migration towards free edges, which fits well with experimentally observed dynamics. We thereby provide a bridge between the biophysical origin of spatiotemporal instabilities and the design principles of robust and efficient long-ranged migration."}],"year":"2021","month":"02","ec_funded":1,"status":"public","oa":1,"publication_identifier":{"eissn":["17452481"],"issn":["17452473"]},"oa_version":"Preprint","date_published":"2021-02-01T00:00:00Z","publication_status":"published","doi":"10.1038/s41567-020-01037-7","intvolume":"        17","citation":{"chicago":"Boocock, Daniel R, Naoya Hino, Natalia Ruzickova, Tsuyoshi Hirashima, and Edouard B Hannezo. “Theory of Mechanochemical Patterning and Optimal Migration in Cell Monolayers.” <i>Nature Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41567-020-01037-7\">https://doi.org/10.1038/s41567-020-01037-7</a>.","apa":"Boocock, D. R., Hino, N., Ruzickova, N., Hirashima, T., &#38; Hannezo, E. B. (2021). Theory of mechanochemical patterning and optimal migration in cell monolayers. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-020-01037-7\">https://doi.org/10.1038/s41567-020-01037-7</a>","mla":"Boocock, Daniel R., et al. “Theory of Mechanochemical Patterning and Optimal Migration in Cell Monolayers.” <i>Nature Physics</i>, vol. 17, Springer Nature, 2021, pp. 267–74, doi:<a href=\"https://doi.org/10.1038/s41567-020-01037-7\">10.1038/s41567-020-01037-7</a>.","ista":"Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. 2021. Theory of mechanochemical patterning and optimal migration in cell monolayers. Nature Physics. 17, 267–274.","short":"D.R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, E.B. Hannezo, Nature Physics 17 (2021) 267–274.","ieee":"D. R. Boocock, N. Hino, N. Ruzickova, T. Hirashima, and E. B. Hannezo, “Theory of mechanochemical patterning and optimal migration in cell monolayers,” <i>Nature Physics</i>, vol. 17. Springer Nature, pp. 267–274, 2021.","ama":"Boocock DR, Hino N, Ruzickova N, Hirashima T, Hannezo EB. Theory of mechanochemical patterning and optimal migration in cell monolayers. <i>Nature Physics</i>. 2021;17:267-274. doi:<a href=\"https://doi.org/10.1038/s41567-020-01037-7\">10.1038/s41567-020-01037-7</a>"},"main_file_link":[{"url":"https://doi.org/10.1101/2020.05.15.096479","open_access":"1"}],"scopus_import":"1","project":[{"_id":"268294B6-B435-11E9-9278-68D0E5697425","grant_number":"P31639","call_identifier":"FWF","name":"Active mechano-chemical description of the cell cytoskeleton"},{"call_identifier":"H2020","name":"Design Principles of Branching Morphogenesis","_id":"05943252-7A3F-11EA-A408-12923DDC885E","grant_number":"851288"},{"call_identifier":"H2020","name":"International IST Doctoral Program","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"isi":1,"author":[{"full_name":"Boocock, Daniel R","last_name":"Boocock","id":"453AF628-F248-11E8-B48F-1D18A9856A87","first_name":"Daniel R","orcid":"0000-0002-1585-2631"},{"first_name":"Naoya","last_name":"Hino","full_name":"Hino, Naoya"},{"full_name":"Ruzickova, Natalia","first_name":"Natalia","id":"D2761128-D73D-11E9-A1BF-BA0DE6697425","last_name":"Ruzickova"},{"full_name":"Hirashima, Tsuyoshi","last_name":"Hirashima","first_name":"Tsuyoshi"},{"full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","first_name":"Edouard B","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"acknowledgement":"We would like to thank G. Tkacik and all of the members of the Hannezo and Hirashima groups for useful discussions, X. Trepat for help on traction force microscopy and M. Matsuda for use of the lab facility. E.H. acknowledges grants from the Austrian Science Fund (FWF) (P 31639) and the European Research Council (851288). T.H. acknowledges a grant from JST, PRESTO (JPMJPR1949). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement no. 665385 (to D.B.), from JSPS KAKENHI grant no. 17J02107 (to N.H.) and from the SPIRITS 2018 of Kyoto University (to E.H. and T.H.).","day":"01","publisher":"Springer Nature","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Theory of mechanochemical patterning and optimal migration in cell monolayers","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"EdHa"}],"date_created":"2020-10-04T22:01:37Z","page":"267-274","publication":"Nature Physics","external_id":{"isi":["000573519500002"]},"volume":17,"quality_controlled":"1","related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/wound-healing-waves/"}],"record":[{"id":"12964","status":"public","relation":"dissertation_contains"}]},"article_type":"original","article_processing_charge":"No"},{"ddc":["510"],"scopus_import":"1","file_date_updated":"2021-03-11T10:03:30Z","citation":{"short":"R. Frank, R. Seiringer, Communications on Pure and Applied Mathematics 74 (2021) 544–588.","ieee":"R. Frank and R. Seiringer, “Quantum corrections to the Pekar asymptotics of a strongly coupled polaron,” <i>Communications on Pure and Applied Mathematics</i>, vol. 74, no. 3. Wiley, pp. 544–588, 2021.","ama":"Frank R, Seiringer R. Quantum corrections to the Pekar asymptotics of a strongly coupled polaron. <i>Communications on Pure and Applied Mathematics</i>. 2021;74(3):544-588. doi:<a href=\"https://doi.org/10.1002/cpa.21944\">10.1002/cpa.21944</a>","ista":"Frank R, Seiringer R. 2021. Quantum corrections to the Pekar asymptotics of a strongly coupled polaron. Communications on Pure and Applied Mathematics. 74(3), 544–588.","mla":"Frank, Rupert, and Robert Seiringer. “Quantum Corrections to the Pekar Asymptotics of a Strongly Coupled Polaron.” <i>Communications on Pure and Applied Mathematics</i>, vol. 74, no. 3, Wiley, 2021, pp. 544–88, doi:<a href=\"https://doi.org/10.1002/cpa.21944\">10.1002/cpa.21944</a>.","apa":"Frank, R., &#38; Seiringer, R. (2021). Quantum corrections to the Pekar asymptotics of a strongly coupled polaron. <i>Communications on Pure and Applied Mathematics</i>. Wiley. <a href=\"https://doi.org/10.1002/cpa.21944\">https://doi.org/10.1002/cpa.21944</a>","chicago":"Frank, Rupert, and Robert Seiringer. “Quantum Corrections to the Pekar Asymptotics of a Strongly Coupled Polaron.” <i>Communications on Pure and Applied Mathematics</i>. Wiley, 2021. <a href=\"https://doi.org/10.1002/cpa.21944\">https://doi.org/10.1002/cpa.21944</a>."},"intvolume":"        74","publication_status":"published","doi":"10.1002/cpa.21944","date_published":"2021-03-01T00:00:00Z","oa_version":"Published Version","publication_identifier":{"issn":["00103640"],"eissn":["10970312"]},"oa":1,"status":"public","ec_funded":1,"month":"03","year":"2021","date_updated":"2023-08-04T11:02:16Z","abstract":[{"lang":"eng","text":"We consider the Fröhlich polaron model in the strong coupling limit. It is well‐known that to leading order the ground state energy is given by the (classical) Pekar energy. In this work, we establish the subleading correction, describing quantum fluctuation about the classical limit. Our proof applies to a model of a confined polaron, where both the electron and the polarization field are restricted to a set of finite volume, with linear size determined by the natural length scale of the Pekar problem."}],"issue":"3","_id":"8603","article_processing_charge":"No","article_type":"original","external_id":{"isi":["000572991500001"]},"quality_controlled":"1","volume":74,"date_created":"2020-10-04T22:01:37Z","page":"544-588","publication":"Communications on Pure and Applied Mathematics","has_accepted_license":"1","language":[{"iso":"eng"}],"department":[{"_id":"RoSe"}],"type":"journal_article","title":"Quantum corrections to the Pekar asymptotics of a strongly coupled polaron","publisher":"Wiley","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"01","acknowledgement":"Partial support through National Science Foundation GrantDMS-1363432 (R.L.F.) and the European Research Council (ERC) under the Euro-pean Union’s Horizon 2020 research and innovation programme (grant agreementNo 694227; R.S.), is acknowledged. Open access funding enabled and organizedby Projekt DEAL.","file":[{"date_updated":"2021-03-11T10:03:30Z","file_name":"2021_CommPureApplMath_Frank.pdf","date_created":"2021-03-11T10:03:30Z","file_id":"9236","creator":"dernst","checksum":"5f665ffa6e6dd958aec5c3040cbcfa84","access_level":"open_access","content_type":"application/pdf","relation":"main_file","success":1,"file_size":334987}],"project":[{"call_identifier":"H2020","name":"Analysis of quantum many-body systems","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","grant_number":"694227"}],"isi":1,"author":[{"first_name":"Rupert","last_name":"Frank","full_name":"Frank, Rupert"},{"orcid":"0000-0002-6781-0521","first_name":"Robert","id":"4AFD0470-F248-11E8-B48F-1D18A9856A87","last_name":"Seiringer","full_name":"Seiringer, Robert"}]},{"publisher":"Wiley","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton","pmid":1,"acknowledgement":"We are thankful to Professor Yuxian Zhu from Wuhan University for his extremely valuable remarks and helpful comments on the manuscript. This work was supported by the Shaanxi Natural Science Foundation (2019JQ‐062 and 2020JQ‐410), Shaanxi Youth Entrusted Talents Program (20190205), China Postdoctoral Science Foundation (2018M640947, 2020T130394), Shaanxi Postdoctoral Project (2018BSHYDZZ76), Natural Science Basic Research Plan in Shaanxi Province of China (2018JZ3006), Fundamental Research Funds for the Central Universities (GK201903064, GK201901004, GK202002005 and GK202001004), and State Key Laboratory of Cotton Biology Open Fund (CB2020A12).","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"01","author":[{"last_name":"He","first_name":"P","full_name":"He, P"},{"first_name":"Yuzhou","orcid":"0000-0003-2627-6956","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87","last_name":"Zhang","full_name":"Zhang, Yuzhou"},{"first_name":"H","last_name":"Li","full_name":"Li, H"},{"first_name":"X","last_name":"Fu","full_name":"Fu, X"},{"last_name":"Shang","first_name":"H","full_name":"Shang, H"},{"full_name":"Zou, C","first_name":"C","last_name":"Zou"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří","full_name":"Friml, Jiří"},{"first_name":"G","last_name":"Xiao","full_name":"Xiao, G"}],"isi":1,"file":[{"access_level":"open_access","creator":"dernst","checksum":"63845be37fb962586e0c7773f2355970","file_id":"9321","date_created":"2021-04-12T12:29:07Z","file_name":"2021_PlantBiotechJournal_He.pdf","date_updated":"2021-04-12T12:29:07Z","file_size":15691871,"success":1,"relation":"main_file","content_type":"application/pdf"}],"article_processing_charge":"No","article_type":"original","external_id":{"isi":["000577682300001"],"pmid":["32981232"]},"quality_controlled":"1","volume":19,"has_accepted_license":"1","date_created":"2020-10-05T12:44:33Z","page":"548-562","publication":"Plant Biotechnology Journal","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"JiFr"}],"status":"public","oa":1,"publication_identifier":{"issn":["1467-7644","1467-7652"]},"month":"03","date_updated":"2023-08-04T11:03:10Z","issue":"3","abstract":[{"lang":"eng","text":"The leaf is a crucial organ evolved with remarkable morphological diversity to maximize plant photosynthesis. The leaf shape is a key trait that affects photosynthesis, flowering rates, disease resistance, and yield. Although many genes regulating leaf development have been identified in the past years, the precise regulatory architecture underlying the generation of diverse leaf shapes remains to be elucidated. We used cotton as a reference model to probe the genetic framework underlying divergent leaf forms. Comparative transcriptome analysis revealed that the GhARF16‐1 and GhKNOX2‐1 genes might be potential regulators of leaf shape. We functionally characterized the auxin‐responsive factor ARF16‐1 acting upstream of GhKNOX2‐1 to determine leaf morphology in cotton. The transcription of GhARF16‐1 was significantly higher in lobed‐leaved cotton than in smooth‐leaved cotton. Furthermore, the overexpression of GhARF16‐1 led to the upregulation of GhKNOX2‐1 and resulted in more and deeper serrations in cotton leaves, similar to the leaf shape of cotton plants overexpressing GhKNOX2‐1. We found that GhARF16‐1 specifically bound to the promoter of GhKNOX2‐1 to induce its expression. The heterologous expression of GhARF16‐1 and GhKNOX2‐1 in Arabidopsis led to lobed and curly leaves, and a genetic analysis revealed that GhKNOX2‐1 is epistatic to GhARF16‐1 in Arabidopsis, suggesting that the GhARF16‐1 and GhKNOX2‐1 interaction paradigm also functions to regulate leaf shape in Arabidopsis. To our knowledge, our results uncover a novel mechanism by which auxin, through the key component ARF16‐1 and its downstream‐activated gene KNOX2‐1, determines leaf morphology in eudicots."}],"year":"2021","_id":"8606","file_date_updated":"2021-04-12T12:29:07Z","scopus_import":"1","ddc":["580"],"intvolume":"        19","citation":{"chicago":"He, P, Yuzhou Zhang, H Li, X Fu, H Shang, C Zou, Jiří Friml, and G Xiao. “GhARF16-1 Modulates Leaf Development by Transcriptionally Regulating the GhKNOX2-1 Gene in Cotton.” <i>Plant Biotechnology Journal</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/pbi.13484\">https://doi.org/10.1111/pbi.13484</a>.","ista":"He P, Zhang Y, Li H, Fu X, Shang H, Zou C, Friml J, Xiao G. 2021. GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton. Plant Biotechnology Journal. 19(3), 548–562.","apa":"He, P., Zhang, Y., Li, H., Fu, X., Shang, H., Zou, C., … Xiao, G. (2021). GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton. <i>Plant Biotechnology Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/pbi.13484\">https://doi.org/10.1111/pbi.13484</a>","mla":"He, P., et al. “GhARF16-1 Modulates Leaf Development by Transcriptionally Regulating the GhKNOX2-1 Gene in Cotton.” <i>Plant Biotechnology Journal</i>, vol. 19, no. 3, Wiley, 2021, pp. 548–62, doi:<a href=\"https://doi.org/10.1111/pbi.13484\">10.1111/pbi.13484</a>.","short":"P. He, Y. Zhang, H. Li, X. Fu, H. Shang, C. Zou, J. Friml, G. Xiao, Plant Biotechnology Journal 19 (2021) 548–562.","ieee":"P. He <i>et al.</i>, “GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton,” <i>Plant Biotechnology Journal</i>, vol. 19, no. 3. Wiley, pp. 548–562, 2021.","ama":"He P, Zhang Y, Li H, et al. GhARF16-1 modulates leaf development by transcriptionally regulating the GhKNOX2-1 gene in cotton. <i>Plant Biotechnology Journal</i>. 2021;19(3):548-562. doi:<a href=\"https://doi.org/10.1111/pbi.13484\">10.1111/pbi.13484</a>"},"publication_status":"published","doi":"10.1111/pbi.13484","oa_version":"Published Version","date_published":"2021-03-01T00:00:00Z"},{"year":"2021","date_updated":"2023-09-05T16:06:24Z","abstract":[{"text":"To adapt to the diverse array of biotic and abiotic cues, plants have evolved sophisticated mechanisms to sense changes in environmental conditions and modulate their growth. Growth-promoting hormones and defence signalling fine tune plant development antagonistically. During host-pathogen interactions, this defence-growth trade-off is mediated by the counteractive effects of the defence hormone salicylic acid (SA) and the growth hormone auxin. Here we revealed an underlying mechanism of SA regulating auxin signalling by constraining the plasma membrane dynamics of PIN2 auxin efflux transporter in Arabidopsis thaliana roots. The lateral diffusion of PIN2 proteins is constrained by SA signalling, during which PIN2 proteins are condensed into hyperclusters depending on REM1.2-mediated nanodomain compartmentalisation. Furthermore, membrane nanodomain compartmentalisation by SA or Remorin (REM) assembly significantly suppressed clathrin-mediated endocytosis. Consequently, SA-induced heterogeneous surface condensation disrupted asymmetric auxin distribution and the resultant gravitropic response. Our results demonstrated a defence-growth trade-off mechanism by which SA signalling crosstalked with auxin transport by concentrating membrane-resident PIN2 into heterogeneous compartments.","lang":"eng"}],"issue":"2","_id":"8608","publication_identifier":{"issn":["0028-646x"],"eissn":["1469-8137"]},"oa":1,"status":"public","month":"01","publication_status":"published","doi":"10.1111/nph.16915","date_published":"2021-01-01T00:00:00Z","oa_version":"Published Version","ddc":["580"],"scopus_import":"1","file_date_updated":"2021-02-04T09:53:16Z","citation":{"ama":"Ke M, Ma Z, Wang D, et al. Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. <i>New Phytologist</i>. 2021;229(2):963-978. doi:<a href=\"https://doi.org/10.1111/nph.16915\">10.1111/nph.16915</a>","ieee":"M. Ke <i>et al.</i>, “Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana,” <i>New Phytologist</i>, vol. 229, no. 2. Wiley, pp. 963–978, 2021.","short":"M. Ke, Z. Ma, D. Wang, Y. Sun, C. Wen, D. Huang, Z. Chen, L. Yang, S. Tan, R. Li, J. Friml, Y. Miao, X. Chen, New Phytologist 229 (2021) 963–978.","mla":"Ke, M., et al. “Salicylic Acid Regulates PIN2 Auxin Transporter Hyper-Clustering and Root Gravitropic Growth via Remorin-Dependent Lipid Nanodomain Organization in Arabidopsis Thaliana.” <i>New Phytologist</i>, vol. 229, no. 2, Wiley, 2021, pp. 963–78, doi:<a href=\"https://doi.org/10.1111/nph.16915\">10.1111/nph.16915</a>.","apa":"Ke, M., Ma, Z., Wang, D., Sun, Y., Wen, C., Huang, D., … Chen, X. (2021). Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. <i>New Phytologist</i>. Wiley. <a href=\"https://doi.org/10.1111/nph.16915\">https://doi.org/10.1111/nph.16915</a>","ista":"Ke M, Ma Z, Wang D, Sun Y, Wen C, Huang D, Chen Z, Yang L, Tan S, Li R, Friml J, Miao Y, Chen X. 2021. Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana. New Phytologist. 229(2), 963–978.","chicago":"Ke, M, Z Ma, D Wang, Y Sun, C Wen, D Huang, Z Chen, et al. “Salicylic Acid Regulates PIN2 Auxin Transporter Hyper-Clustering and Root Gravitropic Growth via Remorin-Dependent Lipid Nanodomain Organization in Arabidopsis Thaliana.” <i>New Phytologist</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/nph.16915\">https://doi.org/10.1111/nph.16915</a>."},"intvolume":"       229","tmp":{"short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"01","acknowledgement":"This work was supported by the National Key Research andDevelopment Programme of China (2017YFA0506100), theNational Natural Science Foundation of China (31870170 and31701168), and the Fok Ying Tung Education Foundation(161027) to XC; NTU startup grant (M4081533) and NIM/01/2016 (NTU, Singapore) to YM. We thank Lei Shi andZhongquan Lin for microscopy assistance.","pmid":1,"file":[{"access_level":"open_access","checksum":"d36b6a8c6fafab66264e0d27114dae63","file_id":"9085","creator":"dernst","date_created":"2021-02-04T09:53:16Z","file_name":"2021_NewPhytologist_Ke.pdf","date_updated":"2021-02-04T09:53:16Z","file_size":3674502,"success":1,"content_type":"application/pdf","relation":"main_file"}],"isi":1,"author":[{"last_name":"Ke","first_name":"M","full_name":"Ke, M"},{"last_name":"Ma","first_name":"Z","full_name":"Ma, Z"},{"last_name":"Wang","first_name":"D","full_name":"Wang, D"},{"last_name":"Sun","first_name":"Y","full_name":"Sun, Y"},{"full_name":"Wen, C","last_name":"Wen","first_name":"C"},{"first_name":"D","last_name":"Huang","full_name":"Huang, D"},{"full_name":"Chen, Z","last_name":"Chen","first_name":"Z"},{"full_name":"Yang, L","first_name":"L","last_name":"Yang"},{"full_name":"Tan, Shutang","orcid":"0000-0002-0471-8285","first_name":"Shutang","last_name":"Tan","id":"2DE75584-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Li, R","first_name":"R","last_name":"Li"},{"full_name":"Friml, Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","first_name":"Jiří"},{"first_name":"Y","last_name":"Miao","full_name":"Miao, Y"},{"full_name":"Chen, X","last_name":"Chen","first_name":"X"}],"title":"Salicylic acid regulates PIN2 auxin transporter hyper-clustering and root gravitropic growth via Remorin-dependent lipid nanodomain organization in Arabidopsis thaliana","publisher":"Wiley","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","date_created":"2020-10-05T12:45:36Z","page":"963-978","publication":"New Phytologist","has_accepted_license":"1","language":[{"iso":"eng"}],"department":[{"_id":"JiFr"}],"type":"journal_article","article_processing_charge":"No","article_type":"original","external_id":{"pmid":["32901934"],"isi":["000573568000001"]},"volume":229,"quality_controlled":"1"},{"language":[{"iso":"eng"}],"department":[{"_id":"KiMo"}],"type":"journal_article","page":"240-244","date_created":"2020-10-18T22:01:37Z","publication":"Nature Physics","external_id":{"isi":["000575344700003"],"arxiv":["2005.04228"]},"volume":17,"quality_controlled":"1","article_processing_charge":"No","article_type":"original","isi":1,"author":[{"full_name":"Modic, Kimberly A","orcid":"0000-0001-9760-3147","first_name":"Kimberly A","last_name":"Modic","id":"13C26AC0-EB69-11E9-87C6-5F3BE6697425"},{"last_name":"McDonald","first_name":"Ross D.","full_name":"McDonald, Ross D."},{"full_name":"Ruff, J.P.C.","first_name":"J.P.C.","last_name":"Ruff"},{"full_name":"Bachmann, Maja D.","last_name":"Bachmann","first_name":"Maja D."},{"first_name":"You","last_name":"Lai","full_name":"Lai, You"},{"full_name":"Palmstrom, Johanna C.","first_name":"Johanna C.","last_name":"Palmstrom"},{"last_name":"Graf","first_name":"David","full_name":"Graf, David"},{"full_name":"Chan, Mun K.","first_name":"Mun K.","last_name":"Chan"},{"full_name":"Balakirev, F.F.","first_name":"F.F.","last_name":"Balakirev"},{"full_name":"Betts, J.B.","first_name":"J.B.","last_name":"Betts"},{"full_name":"Boebinger, G.S.","first_name":"G.S.","last_name":"Boebinger"},{"full_name":"Schmidt, Marcus","last_name":"Schmidt","first_name":"Marcus"},{"full_name":"Lawler, Michael J.","first_name":"Michael J.","last_name":"Lawler"},{"last_name":"Sokolov","first_name":"D.A.","full_name":"Sokolov, D.A."},{"full_name":"Moll, Philip J.W.","last_name":"Moll","first_name":"Philip J.W."},{"full_name":"Ramshaw, B.J.","first_name":"B.J.","last_name":"Ramshaw"},{"last_name":"Shekhter","first_name":"Arkady","full_name":"Shekhter, Arkady"}],"day":"01","acknowledgement":"We thank M. Baenitz, A. Bangura, R. Coldea, G. Jackeli, S. Kivelson, S. Nagler, R. Valenti, C. Varma, S. Winter and J. Zaanen for insightful discussions. Samples were grown at the Max Planck Institute for Chemical Physics of Solids. The d.c.-field measurements were made at the National High Magnetic Field Laboratory (NHMFL) in Tallahassee, FL. The pulsed-field measurements were made in the Pulsed Field Facility of the NHMFL in Los Alamos, NM. All work at the NHMFL is supported through the National Science Foundation Cooperative Agreement nos. DMR-1157490 and DMR-1644779, the US Department of Energy and the State of Florida. R.D.M. acknowledges support from LANL LDRD-DR 20160085 Topology and Strong Correlations. M.C. acknowledges support from the Department of Energy ‘Science of 100 tesla’ BES programme for high-field experiments. X-ray data acquisition and analysis was performed at Cornell University. Research conducted at the Cornell High Energy Synchrotron Source (CHESS) is supported by the National Science Foundation under award no. DMR-1332208. B.J.R. acknowledges support from the Institute for Quantum Matter, an Energy Frontier Research Center funded by the US Department of Energy, Office of Science, Office of Basic Energy Sciences under award no. DE-SC0019331. Y.L. acknowledges support from the US Department of Energy through the LANL/LDRD programme and the G.T. Seaborg institute. J.C.P. is supported by a Gabilan Stanford Graduate Fellowship and an NSF Graduate Research Fellowship (grant no. DGE-114747). P.J.W.M. acknowledges funding from the Swiss National Science Foundation through project no. PP00P2-176789.","title":"Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields","publisher":"Springer Nature","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2021-02-01T00:00:00Z","oa_version":"Preprint","publication_status":"published","doi":"10.1038/s41567-020-1028-0","citation":{"ista":"Modic KA, McDonald RD, Ruff JPC, Bachmann MD, Lai Y, Palmstrom JC, Graf D, Chan MK, Balakirev FF, Betts JB, Boebinger GS, Schmidt M, Lawler MJ, Sokolov DA, Moll PJW, Ramshaw BJ, Shekhter A. 2021. Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields. Nature Physics. 17, 240–244.","mla":"Modic, Kimberly A., et al. “Scale-Invariant Magnetic Anisotropy in RuCl3 at High Magnetic Fields.” <i>Nature Physics</i>, vol. 17, Springer Nature, 2021, pp. 240–44, doi:<a href=\"https://doi.org/10.1038/s41567-020-1028-0\">10.1038/s41567-020-1028-0</a>.","apa":"Modic, K. A., McDonald, R. D., Ruff, J. P. C., Bachmann, M. D., Lai, Y., Palmstrom, J. C., … Shekhter, A. (2021). Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-020-1028-0\">https://doi.org/10.1038/s41567-020-1028-0</a>","chicago":"Modic, Kimberly A, Ross D. McDonald, J.P.C. Ruff, Maja D. Bachmann, You Lai, Johanna C. Palmstrom, David Graf, et al. “Scale-Invariant Magnetic Anisotropy in RuCl3 at High Magnetic Fields.” <i>Nature Physics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41567-020-1028-0\">https://doi.org/10.1038/s41567-020-1028-0</a>.","short":"K.A. Modic, R.D. McDonald, J.P.C. Ruff, M.D. Bachmann, Y. Lai, J.C. Palmstrom, D. Graf, M.K. Chan, F.F. Balakirev, J.B. Betts, G.S. Boebinger, M. Schmidt, M.J. Lawler, D.A. Sokolov, P.J.W. Moll, B.J. Ramshaw, A. Shekhter, Nature Physics 17 (2021) 240–244.","ieee":"K. A. Modic <i>et al.</i>, “Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields,” <i>Nature Physics</i>, vol. 17. Springer Nature, pp. 240–244, 2021.","ama":"Modic KA, McDonald RD, Ruff JPC, et al. Scale-invariant magnetic anisotropy in RuCl3 at high magnetic fields. <i>Nature Physics</i>. 2021;17:240-244. doi:<a href=\"https://doi.org/10.1038/s41567-020-1028-0\">10.1038/s41567-020-1028-0</a>"},"intvolume":"        17","main_file_link":[{"url":"https://arxiv.org/abs/2005.04228","open_access":"1"}],"scopus_import":"1","_id":"8673","year":"2021","date_updated":"2023-08-04T11:03:39Z","arxiv":1,"abstract":[{"text":"In RuCl3, inelastic neutron scattering and Raman spectroscopy reveal a continuum of non-spin-wave excitations that persists to high temperature, suggesting the presence of a spin liquid state on a honeycomb lattice. In the context of the Kitaev model, finite magnetic fields introduce interactions between the elementary excitations, and thus the effects of high magnetic fields that are comparable to the spin-exchange energy scale must be explored. Here, we report measurements of the magnetotropic coefficient—the thermodynamic coefficient associated with magnetic anisotropy—over a wide range of magnetic fields and temperatures. We find that magnetic field and temperature compete to determine the magnetic response in a way that is independent of the large intrinsic exchange-interaction energy. This emergent scale-invariant magnetic anisotropy provides evidence for a high degree of exchange frustration that favours the formation of a spin liquid state in RuCl3.","lang":"eng"}],"month":"02","oa":1,"publication_identifier":{"eissn":["17452481"],"issn":["17452473"]},"status":"public"},{"date_updated":"2023-08-07T13:37:27Z","arxiv":1,"abstract":[{"text":"This paper continues the discussion started in [CK19] concerning Arnold's legacy on classical KAM theory and (some of) its modern developments. We prove a detailed and explicit `global' Arnold's KAM Theorem, which yields, in particular, the Whitney conjugacy of a non{degenerate, real{analytic, nearly-integrable Hamiltonian system to an integrable system on a closed, nowhere dense, positive measure subset of the phase space. Detailed measure estimates on the Kolmogorov's set are provided in the case the phase space is: (A) a uniform neighbourhood of an arbitrary (bounded) set times the d-torus and (B) a domain with C2 boundary times the d-torus. All constants are explicitly given.","lang":"eng"}],"issue":"1","year":"2021","_id":"8689","status":"public","oa":1,"publication_identifier":{"issn":["1560-3547"]},"month":"02","publication_status":"published","doi":"10.1134/S1560354721010044","oa_version":"Preprint","date_published":"2021-02-03T00:00:00Z","scopus_import":"1","main_file_link":[{"url":"https://arxiv.org/abs/2010.13243","open_access":"1"}],"ddc":["515"],"intvolume":"        26","citation":{"ista":"Chierchia L, Koudjinan E. 2021. V.I. Arnold’s ‘“Global”’ KAM theorem and geometric measure estimates. Regular and Chaotic Dynamics. 26(1), 61–88.","apa":"Chierchia, L., &#38; Koudjinan, E. (2021). V.I. Arnold’s “‘Global’” KAM theorem and geometric measure estimates. <i>Regular and Chaotic Dynamics</i>. Springer Nature. <a href=\"https://doi.org/10.1134/S1560354721010044\">https://doi.org/10.1134/S1560354721010044</a>","mla":"Chierchia, Luigi, and Edmond Koudjinan. “V.I. Arnold’s ‘“Global”’ KAM Theorem and Geometric Measure Estimates.” <i>Regular and Chaotic Dynamics</i>, vol. 26, no. 1, Springer Nature, 2021, pp. 61–88, doi:<a href=\"https://doi.org/10.1134/S1560354721010044\">10.1134/S1560354721010044</a>.","chicago":"Chierchia, Luigi, and Edmond Koudjinan. “V.I. Arnold’s ‘“Global”’ KAM Theorem and Geometric Measure Estimates.” <i>Regular and Chaotic Dynamics</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1134/S1560354721010044\">https://doi.org/10.1134/S1560354721010044</a>.","short":"L. Chierchia, E. Koudjinan, Regular and Chaotic Dynamics 26 (2021) 61–88.","ieee":"L. Chierchia and E. Koudjinan, “V.I. Arnold’s ‘“Global”’ KAM theorem and geometric measure estimates,” <i>Regular and Chaotic Dynamics</i>, vol. 26, no. 1. Springer Nature, pp. 61–88, 2021.","ama":"Chierchia L, Koudjinan E. V.I. Arnold’s “‘Global’” KAM theorem and geometric measure estimates. <i>Regular and Chaotic Dynamics</i>. 2021;26(1):61-88. doi:<a href=\"https://doi.org/10.1134/S1560354721010044\">10.1134/S1560354721010044</a>"},"day":"03","author":[{"full_name":"Chierchia, Luigi","last_name":"Chierchia","first_name":"Luigi"},{"full_name":"Koudjinan, Edmond","id":"52DF3E68-AEFA-11EA-95A4-124A3DDC885E","last_name":"Koudjinan","orcid":"0000-0003-2640-4049","first_name":"Edmond"}],"isi":1,"publisher":"Springer Nature","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"V.I. Arnold's ''Global'' KAM theorem and geometric measure estimates","date_created":"2020-10-21T14:56:47Z","page":"61-88","publication":"Regular and Chaotic Dynamics","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"VaKa"}],"article_processing_charge":"No","article_type":"original","external_id":{"isi":["000614454700004"],"arxiv":["2010.13243"]},"volume":26,"quality_controlled":"1","keyword":["Nearly{integrable Hamiltonian systems","perturbation theory","KAM Theory","Arnold's scheme","Kolmogorov's set","primary invariant tori","Lagrangian tori","measure estimates","small divisors","integrability on nowhere dense sets","Diophantine frequencies."]},{"article_processing_charge":"No","article_type":"original","volume":34,"quality_controlled":"1","external_id":{"isi":["000579599700001"],"pmid":["33045123"]},"related_material":{"record":[{"relation":"research_data","status":"public","id":"13073"}]},"publication":"Journal of Evolutionary Biology","date_created":"2020-10-25T23:01:20Z","page":"208-223","type":"journal_article","department":[{"_id":"BeVi"},{"_id":"NiBa"}],"language":[{"iso":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Wiley","title":"How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels","pmid":1,"acknowledgement":"Data used in this work were partly produced through the genotyping and sequencing facilities of ISEM and LabEx CeMEB, an ANR ‘Investissements d'avenir’ program (ANR‐10‐LABX‐04‐01) This project benefited from the Montpellier Bioinformatics Biodiversity platform supported by the LabEx CeMEB. We thank Norah Saarman, Grant Pogson, Célia Gosset and Pierre‐Alexandre Gagnaire for providing samples. This work was funded by a Languedoc‐Roussillon ‘Chercheur(se)s d'Avenir’ grant (Connect7 project). P. Strelkov was supported by the Russian Science Foundation project 19‐74‐20024. This is article 2020‐240 of Institut des Sciences de l'Evolution de Montpellier.","day":"01","isi":1,"author":[{"full_name":"Simon, Alexis","first_name":"Alexis","last_name":"Simon"},{"full_name":"Fraisse, Christelle","orcid":"0000-0001-8441-5075","first_name":"Christelle","id":"32DF5794-F248-11E8-B48F-1D18A9856A87","last_name":"Fraisse"},{"full_name":"El Ayari, Tahani","first_name":"Tahani","last_name":"El Ayari"},{"full_name":"Liautard‐Haag, Cathy","last_name":"Liautard‐Haag","first_name":"Cathy"},{"first_name":"Petr","last_name":"Strelkov","full_name":"Strelkov, Petr"},{"first_name":"John J","last_name":"Welch","full_name":"Welch, John J"},{"full_name":"Bierne, Nicolas","first_name":"Nicolas","last_name":"Bierne"}],"scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/818559"}],"citation":{"apa":"Simon, A., Fraisse, C., El Ayari, T., Liautard‐Haag, C., Strelkov, P., Welch, J. J., &#38; Bierne, N. (2021). How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels. <i>Journal of Evolutionary Biology</i>. Wiley. <a href=\"https://doi.org/10.1111/jeb.13709\">https://doi.org/10.1111/jeb.13709</a>","mla":"Simon, Alexis, et al. “How Do Species Barriers Decay? Concordance and Local Introgression in Mosaic Hybrid Zones of Mussels.” <i>Journal of Evolutionary Biology</i>, vol. 34, no. 1, Wiley, 2021, pp. 208–23, doi:<a href=\"https://doi.org/10.1111/jeb.13709\">10.1111/jeb.13709</a>.","ista":"Simon A, Fraisse C, El Ayari T, Liautard‐Haag C, Strelkov P, Welch JJ, Bierne N. 2021. How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels. Journal of Evolutionary Biology. 34(1), 208–223.","chicago":"Simon, Alexis, Christelle Fraisse, Tahani El Ayari, Cathy Liautard‐Haag, Petr Strelkov, John J Welch, and Nicolas Bierne. “How Do Species Barriers Decay? Concordance and Local Introgression in Mosaic Hybrid Zones of Mussels.” <i>Journal of Evolutionary Biology</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/jeb.13709\">https://doi.org/10.1111/jeb.13709</a>.","ieee":"A. Simon <i>et al.</i>, “How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels,” <i>Journal of Evolutionary Biology</i>, vol. 34, no. 1. Wiley, pp. 208–223, 2021.","ama":"Simon A, Fraisse C, El Ayari T, et al. How do species barriers decay? Concordance and local introgression in mosaic hybrid zones of mussels. <i>Journal of Evolutionary Biology</i>. 2021;34(1):208-223. doi:<a href=\"https://doi.org/10.1111/jeb.13709\">10.1111/jeb.13709</a>","short":"A. Simon, C. Fraisse, T. El Ayari, C. Liautard‐Haag, P. Strelkov, J.J. Welch, N. Bierne, Journal of Evolutionary Biology 34 (2021) 208–223."},"intvolume":"        34","doi":"10.1111/jeb.13709","publication_status":"published","oa_version":"Preprint","date_published":"2021-01-01T00:00:00Z","status":"public","publication_identifier":{"eissn":["14209101"],"issn":["1010061X"]},"oa":1,"month":"01","abstract":[{"text":"The Mytilus complex of marine mussel species forms a mosaic of hybrid zones, found across temperate regions of the globe. This allows us to study ‘replicated’ instances of secondary contact between closely related species. Previous work on this complex has shown that local introgression is both widespread and highly heterogeneous, and has identified SNPs that are outliers of differentiation between lineages. Here, we developed an ancestry‐informative panel of such SNPs. We then compared their frequencies in newly sampled populations, including samples from within the hybrid zones, and parental populations at different distances from the contact. Results show that close to the hybrid zones, some outlier loci are near to fixation for the heterospecific allele, suggesting enhanced local introgression, or the local sweep of a shared ancestral allele. Conversely, genomic cline analyses, treating local parental populations as the reference, reveal a globally high concordance among loci, albeit with a few signals of asymmetric introgression. Enhanced local introgression at specific loci is consistent with the early transfer of adaptive variants after contact, possibly including asymmetric bi‐stable variants (Dobzhansky‐Muller incompatibilities), or haplotypes loaded with fewer deleterious mutations. Having escaped one barrier, however, these variants can be trapped or delayed at the next barrier, confining the introgression locally. These results shed light on the decay of species barriers during phases of contact.","lang":"eng"}],"issue":"1","date_updated":"2023-08-04T11:04:11Z","year":"2021","_id":"8708"},{"language":[{"iso":"eng"}],"department":[{"_id":"DaAl"}],"type":"journal_article","date_created":"2020-11-05T15:25:43Z","publication":"IEEE Transactions on Parallel and Distributed Systems","external_id":{"arxiv":["2005.00124"],"isi":["000621405200019"]},"quality_controlled":"1","volume":32,"article_type":"original","article_processing_charge":"No","project":[{"call_identifier":"H2020","name":"Elastic Coordination for Scalable Machine Learning","_id":"268A44D6-B435-11E9-9278-68D0E5697425","grant_number":"805223"}],"author":[{"first_name":"Shigang","last_name":"Li","full_name":"Li, Shigang"},{"first_name":"Tal Ben-Nun","last_name":"Tal Ben-Nun","full_name":"Tal Ben-Nun, Tal Ben-Nun"},{"full_name":"Nadiradze, Giorgi","last_name":"Nadiradze","id":"3279A00C-F248-11E8-B48F-1D18A9856A87","first_name":"Giorgi"},{"full_name":"Girolamo, Salvatore Di","first_name":"Salvatore Di","last_name":"Girolamo"},{"last_name":"Dryden","first_name":"Nikoli","full_name":"Dryden, Nikoli"},{"full_name":"Alistarh, Dan-Adrian","id":"4A899BFC-F248-11E8-B48F-1D18A9856A87","last_name":"Alistarh","first_name":"Dan-Adrian","orcid":"0000-0003-3650-940X"},{"full_name":"Hoefler, Torsten","last_name":"Hoefler","first_name":"Torsten"}],"isi":1,"day":"01","acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Hori-\r\nzon 2020 programme under Grant DAPP, Grant 678880; EPi-GRAM-HS, Grant 801039; and ERC Starting Grant ScaleML, Grant 805223. The work of Tal Ben-Nun is supported by the Swiss National Science Foundation (Ambizione Project No. 185778). The work of Nikoli Dryden is supported by the ETH Postdoctoral Fellowship. The authors would like to thank the Swiss National Supercomputing Center for providing the computing resources and technical support.","title":"Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging","publisher":"IEEE","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_published":"2021-07-01T00:00:00Z","oa_version":"Preprint","publication_status":"published","doi":"10.1109/TPDS.2020.3040606","citation":{"short":"S. Li, T.B.-N. Tal Ben-Nun, G. Nadiradze, S.D. Girolamo, N. Dryden, D.-A. Alistarh, T. Hoefler, IEEE Transactions on Parallel and Distributed Systems 32 (2021).","ama":"Li S, Tal Ben-Nun TB-N, Nadiradze G, et al. Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging. <i>IEEE Transactions on Parallel and Distributed Systems</i>. 2021;32(7). doi:<a href=\"https://doi.org/10.1109/TPDS.2020.3040606\">10.1109/TPDS.2020.3040606</a>","ieee":"S. Li <i>et al.</i>, “Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging,” <i>IEEE Transactions on Parallel and Distributed Systems</i>, vol. 32, no. 7. IEEE, 2021.","apa":"Li, S., Tal Ben-Nun, T. B.-N., Nadiradze, G., Girolamo, S. D., Dryden, N., Alistarh, D.-A., &#38; Hoefler, T. (2021). Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging. <i>IEEE Transactions on Parallel and Distributed Systems</i>. IEEE. <a href=\"https://doi.org/10.1109/TPDS.2020.3040606\">https://doi.org/10.1109/TPDS.2020.3040606</a>","mla":"Li, Shigang, et al. “Breaking (Global) Barriers in Parallel Stochastic Optimization with Wait-Avoiding Group Averaging.” <i>IEEE Transactions on Parallel and Distributed Systems</i>, vol. 32, no. 7, 9271898, IEEE, 2021, doi:<a href=\"https://doi.org/10.1109/TPDS.2020.3040606\">10.1109/TPDS.2020.3040606</a>.","ista":"Li S, Tal Ben-Nun TB-N, Nadiradze G, Girolamo SD, Dryden N, Alistarh D-A, Hoefler T. 2021. Breaking (global) barriers in parallel stochastic optimization with wait-avoiding group averaging. IEEE Transactions on Parallel and Distributed Systems. 32(7), 9271898.","chicago":"Li, Shigang, Tal Ben-Nun Tal Ben-Nun, Giorgi Nadiradze, Salvatore Di Girolamo, Nikoli Dryden, Dan-Adrian Alistarh, and Torsten Hoefler. “Breaking (Global) Barriers in Parallel Stochastic Optimization with Wait-Avoiding Group Averaging.” <i>IEEE Transactions on Parallel and Distributed Systems</i>. IEEE, 2021. <a href=\"https://doi.org/10.1109/TPDS.2020.3040606\">https://doi.org/10.1109/TPDS.2020.3040606</a>."},"intvolume":"        32","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2005.00124"}],"_id":"8723","article_number":"9271898","year":"2021","date_updated":"2023-08-04T11:08:52Z","abstract":[{"text":"Deep learning at scale is dominated by communication time. Distributing samples across nodes usually yields the best performance, but poses scaling challenges due to global information dissemination and load imbalance across uneven sample lengths. State-of-the-art decentralized optimizers mitigate the problem, but require more iterations to achieve the same accuracy as their globally-communicating counterparts. We present Wait-Avoiding Group Model Averaging (WAGMA) SGD, a wait-avoiding stochastic optimizer that reduces global communication via subgroup weight exchange. The key insight is a combination of algorithmic changes to the averaging scheme and the use of a group allreduce operation. We prove the convergence of WAGMA-SGD, and empirically show that it retains convergence rates similar to Allreduce-SGD. For evaluation, we train ResNet-50 on ImageNet; Transformer for machine translation; and deep reinforcement learning for navigation at scale. Compared with state-of-the-art decentralized SGD variants, WAGMA-SGD significantly improves training throughput (e.g., 2.1× on 1,024 GPUs for reinforcement learning), and achieves the fastest time-to-solution (e.g., the highest score using the shortest training time for Transformer).","lang":"eng"}],"issue":"7","arxiv":1,"ec_funded":1,"month":"07","publication_identifier":{"issn":["10459219"]},"oa":1,"status":"public"},{"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8221757/"}],"scopus_import":"1","citation":{"short":"N. Tournier, S. Goutal, S. Mairinger, I. Lozano, T. Filip, M. Sauberer, F. Caillé, L. Breuil, J. Stanek, A. Freeman, G. Novarino, C. Truillet, T. Wanek, O. Langer, Journal of Cerebral Blood Flow and Metabolism 41 (2021) 1634–1646.","ama":"Tournier N, Goutal S, Mairinger S, et al. Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. <i>Journal of Cerebral Blood Flow and Metabolism</i>. 2021;41(7):1634-1646. doi:<a href=\"https://doi.org/10.1177/0271678X20965500\">10.1177/0271678X20965500</a>","ieee":"N. Tournier <i>et al.</i>, “Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib,” <i>Journal of Cerebral Blood Flow and Metabolism</i>, vol. 41, no. 7. SAGE Publications, pp. 1634–1646, 2021.","apa":"Tournier, N., Goutal, S., Mairinger, S., Lozano, I., Filip, T., Sauberer, M., … Langer, O. (2021). Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. <i>Journal of Cerebral Blood Flow and Metabolism</i>. SAGE Publications. <a href=\"https://doi.org/10.1177/0271678X20965500\">https://doi.org/10.1177/0271678X20965500</a>","ista":"Tournier N, Goutal S, Mairinger S, Lozano I, Filip T, Sauberer M, Caillé F, Breuil L, Stanek J, Freeman A, Novarino G, Truillet C, Wanek T, Langer O. 2021. Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib. Journal of Cerebral Blood Flow and Metabolism. 41(7), 1634–1646.","mla":"Tournier, N., et al. “Complete Inhibition of ABCB1 and ABCG2 at the Blood-Brain Barrier by Co-Infusion of Erlotinib and Tariquidar to Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” <i>Journal of Cerebral Blood Flow and Metabolism</i>, vol. 41, no. 7, SAGE Publications, 2021, pp. 1634–46, doi:<a href=\"https://doi.org/10.1177/0271678X20965500\">10.1177/0271678X20965500</a>.","chicago":"Tournier, N, S Goutal, S Mairinger, IH Lozano, T Filip, M Sauberer, F Caillé, et al. “Complete Inhibition of ABCB1 and ABCG2 at the Blood-Brain Barrier by Co-Infusion of Erlotinib and Tariquidar to Improve Brain Delivery of the Model ABCB1/ABCG2 Substrate [11C]Erlotinib.” <i>Journal of Cerebral Blood Flow and Metabolism</i>. SAGE Publications, 2021. <a href=\"https://doi.org/10.1177/0271678X20965500\">https://doi.org/10.1177/0271678X20965500</a>."},"intvolume":"        41","publication_status":"published","doi":"10.1177/0271678X20965500","oa_version":"Published Version","date_published":"2021-07-01T00:00:00Z","status":"public","publication_identifier":{"issn":["0271-678x"],"eissn":["1559-7016"]},"oa":1,"month":"07","date_updated":"2023-10-18T06:45:30Z","abstract":[{"text":"P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) restrict at the blood–brain barrier (BBB) the brain distribution of the majority of currently known molecularly targeted anticancer drugs. To improve brain delivery of dual ABCB1/ABCG2 substrates, both ABCB1 and ABCG2 need to be inhibited simultaneously at the BBB. We examined the feasibility of simultaneous ABCB1/ABCG2 inhibition with i.v. co-infusion of erlotinib and tariquidar by studying brain distribution of the model ABCB1/ABCG2 substrate [11C]erlotinib in mice and rhesus macaques with PET. Tolerability of the erlotinib/tariquidar combination was assessed in human embryonic stem cell-derived cerebral organoids. In mice and macaques, baseline brain distribution of [11C]erlotinib was low (brain distribution volume, VT,brain < 0.3 mL/cm3). Co-infusion of erlotinib and tariquidar increased VT,brain in mice by 3.0-fold and in macaques by 3.4- to 5.0-fold, while infusion of erlotinib alone or tariquidar alone led to less pronounced VT,brain increases in both species. Treatment of cerebral organoids with erlotinib/tariquidar led to an induction of Caspase-3-dependent apoptosis. Co-infusion of erlotinib/tariquidar may potentially allow for complete ABCB1/ABCG2 inhibition at the BBB, while simultaneously achieving brain-targeted EGFR inhibition. Our protocol may be applicable to enhance brain delivery of molecularly targeted anticancer drugs for a more effective treatment of brain tumors.","lang":"eng"}],"issue":"7","year":"2021","_id":"8730","article_processing_charge":"No","article_type":"original","external_id":{"isi":["000664214100012"],"pmid":["33081568"]},"quality_controlled":"1","volume":41,"date_created":"2020-11-06T08:39:01Z","page":"1634-1646","publication":"Journal of Cerebral Blood Flow and Metabolism","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"GaNo"}],"publisher":"SAGE Publications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib","pmid":1,"day":"01","author":[{"last_name":"Tournier","first_name":"N","full_name":"Tournier, N"},{"full_name":"Goutal, S","first_name":"S","last_name":"Goutal"},{"full_name":"Mairinger, S","last_name":"Mairinger","first_name":"S"},{"last_name":"Lozano","first_name":"IH","full_name":"Lozano, IH"},{"full_name":"Filip, T","first_name":"T","last_name":"Filip"},{"full_name":"Sauberer, M","last_name":"Sauberer","first_name":"M"},{"full_name":"Caillé, F","first_name":"F","last_name":"Caillé"},{"full_name":"Breuil, L","first_name":"L","last_name":"Breuil"},{"full_name":"Stanek, J","last_name":"Stanek","first_name":"J"},{"full_name":"Freeman, AF","first_name":"AF","last_name":"Freeman"},{"full_name":"Novarino, Gaia","first_name":"Gaia","orcid":"0000-0002-7673-7178","last_name":"Novarino","id":"3E57A680-F248-11E8-B48F-1D18A9856A87"},{"first_name":"C","last_name":"Truillet","full_name":"Truillet, C"},{"last_name":"Wanek","first_name":"T","full_name":"Wanek, T"},{"full_name":"Langer, O","first_name":"O","last_name":"Langer"}],"isi":1},{"article_processing_charge":"No","article_type":"original","volume":33,"quality_controlled":"1","external_id":{"arxiv":["2003.09593"],"isi":["000604750900008"]},"publication":"Forum Mathematicum","page":"147-165","date_created":"2020-11-08T23:01:25Z","department":[{"_id":"TiBr"}],"language":[{"iso":"eng"}],"type":"journal_article","title":"The geometric sieve for quadrics","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"De Gruyter","day":"01","author":[{"id":"35827D50-F248-11E8-B48F-1D18A9856A87","last_name":"Browning","first_name":"Timothy D","orcid":"0000-0002-8314-0177","full_name":"Browning, Timothy D"},{"full_name":"Heath-Brown, Roger","last_name":"Heath-Brown","first_name":"Roger"}],"isi":1,"project":[{"name":"New frontiers of the Manin conjecture","call_identifier":"FWF","grant_number":"P32428","_id":"26AEDAB2-B435-11E9-9278-68D0E5697425"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2003.09593"}],"scopus_import":"1","citation":{"chicago":"Browning, Timothy D, and Roger Heath-Brown. “The Geometric Sieve for Quadrics.” <i>Forum Mathematicum</i>. De Gruyter, 2021. <a href=\"https://doi.org/10.1515/forum-2020-0074\">https://doi.org/10.1515/forum-2020-0074</a>.","mla":"Browning, Timothy D., and Roger Heath-Brown. “The Geometric Sieve for Quadrics.” <i>Forum Mathematicum</i>, vol. 33, no. 1, De Gruyter, 2021, pp. 147–65, doi:<a href=\"https://doi.org/10.1515/forum-2020-0074\">10.1515/forum-2020-0074</a>.","apa":"Browning, T. D., &#38; Heath-Brown, R. (2021). The geometric sieve for quadrics. <i>Forum Mathematicum</i>. De Gruyter. <a href=\"https://doi.org/10.1515/forum-2020-0074\">https://doi.org/10.1515/forum-2020-0074</a>","ista":"Browning TD, Heath-Brown R. 2021. The geometric sieve for quadrics. Forum Mathematicum. 33(1), 147–165.","ama":"Browning TD, Heath-Brown R. The geometric sieve for quadrics. <i>Forum Mathematicum</i>. 2021;33(1):147-165. doi:<a href=\"https://doi.org/10.1515/forum-2020-0074\">10.1515/forum-2020-0074</a>","ieee":"T. D. Browning and R. Heath-Brown, “The geometric sieve for quadrics,” <i>Forum Mathematicum</i>, vol. 33, no. 1. De Gruyter, pp. 147–165, 2021.","short":"T.D. Browning, R. Heath-Brown, Forum Mathematicum 33 (2021) 147–165."},"intvolume":"        33","doi":"10.1515/forum-2020-0074","publication_status":"published","date_published":"2021-01-01T00:00:00Z","oa_version":"Preprint","publication_identifier":{"eissn":["1435-5337"],"issn":["0933-7741"]},"oa":1,"status":"public","month":"01","year":"2021","arxiv":1,"abstract":[{"lang":"eng","text":"We develop a version of Ekedahl’s geometric sieve for integral quadratic forms of rank at least five. As one ranges over the zeros of such quadratic forms, we use the sieve to compute the density of coprime values of polynomials, and furthermore, to address a question about local solubility in families of varieties parameterised by the zeros."}],"issue":"1","date_updated":"2023-10-17T07:39:01Z","_id":"8742"},{"publication_status":"published","doi":"10.1111/evo.14111","oa_version":"Submitted Version","date_published":"2021-02-01T00:00:00Z","main_file_link":[{"open_access":"1","url":"http://hdl.handle.net/10261/223937"}],"scopus_import":"1","citation":{"ieee":"A. Salces-Castellano <i>et al.</i>, “Long-term cloud forest response to climate warming revealed by insect speciation history,” <i>Evolution</i>, vol. 75, no. 2. Wiley, pp. 231–244, 2021.","ama":"Salces-Castellano A, Stankowski S, Arribas P, et al. Long-term cloud forest response to climate warming revealed by insect speciation history. <i>Evolution</i>. 2021;75(2):231-244. doi:<a href=\"https://doi.org/10.1111/evo.14111\">10.1111/evo.14111</a>","short":"A. Salces-Castellano, S. Stankowski, P. Arribas, J. Patino, D.N. Karger, R. Butlin, B.C. Emerson, Evolution 75 (2021) 231–244.","chicago":"Salces-Castellano, Antonia, Sean Stankowski, Paula Arribas, Jairo Patino, Dirk N.  Karger, Roger Butlin, and Brent C. Emerson. “Long-Term Cloud Forest Response to Climate Warming Revealed by Insect Speciation History.” <i>Evolution</i>. Wiley, 2021. <a href=\"https://doi.org/10.1111/evo.14111\">https://doi.org/10.1111/evo.14111</a>.","apa":"Salces-Castellano, A., Stankowski, S., Arribas, P., Patino, J., Karger, D. N., Butlin, R., &#38; Emerson, B. C. (2021). Long-term cloud forest response to climate warming revealed by insect speciation history. <i>Evolution</i>. Wiley. <a href=\"https://doi.org/10.1111/evo.14111\">https://doi.org/10.1111/evo.14111</a>","mla":"Salces-Castellano, Antonia, et al. “Long-Term Cloud Forest Response to Climate Warming Revealed by Insect Speciation History.” <i>Evolution</i>, vol. 75, no. 2, Wiley, 2021, pp. 231–44, doi:<a href=\"https://doi.org/10.1111/evo.14111\">10.1111/evo.14111</a>.","ista":"Salces-Castellano A, Stankowski S, Arribas P, Patino J, Karger DN, Butlin R, Emerson BC. 2021. Long-term cloud forest response to climate warming revealed by insect speciation history. Evolution. 75(2), 231–244."},"intvolume":"        75","date_updated":"2023-08-04T11:09:49Z","abstract":[{"text":"Montane cloud forests are areas of high endemism, and are one of the more vulnerable terrestrial ecosystems to climate change. Thus, understanding how they both contribute to the generation of biodiversity, and will respond to ongoing climate change, are important and related challenges. The widely accepted model for montane cloud forest dynamics involves upslope forcing of their range limits with global climate warming. However, limited climate data provides some support for an alternative model, where range limits are forced downslope with climate warming. Testing between these two models is challenging, due to the inherent limitations of climate and pollen records. We overcome this with an alternative source of historical information, testing between competing model predictions using genomic data and demographic analyses for a species of beetle tightly associated to an oceanic island cloud forest. Results unequivocally support the alternative model: populations that were isolated at higher elevation peaks during the Last Glacial Maximum are now in contact and hybridizing at lower elevations. Our results suggest that genomic data are a rich source of information to further understand how montane cloud forest biodiversity originates, and how it is likely to be impacted by ongoing climate change.","lang":"eng"}],"issue":"2","year":"2021","_id":"8743","status":"public","publication_identifier":{"issn":["0014-3820"],"eissn":["1558-5646"]},"oa":1,"month":"02","page":"231-244","date_created":"2020-11-08T23:01:26Z","publication":"Evolution","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"NiBa"}],"article_type":"original","article_processing_charge":"No","external_id":{"pmid":["33078844"],"isi":["000583190600001"]},"volume":75,"quality_controlled":"1","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1111/evo.14225"}]},"pmid":1,"acknowledgement":"This work was financed by the Spanish Agencia Estatal de Investigación (CGL2017‐85718‐P), awarded to BCE, and co‐financed by FEDER. It was also supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (EQC2018‐004418‐P), awarded to BCE. AS‐C was funded by the Spanish Ministerio de Ciencia, Innovación y Universidades through an FPU PhD fellowship (FPU014/02948). The authors thank Instituto Tecnológico y de Energías Renovables (ITER), S.A for providing access to the Teide High‐Performance Computing facility (Teide‐HPC). Fieldwork was supported by collecting permit AFF 107/17 (sigma number 2017‐00572) kindly provided by the Cabildo of Tenerife. The authors wish to thank the following for field work and sample sorting and identification: A. J. Pérez‐Delgado, H. López, and C. Andújar. We also thank V. García‐Olivares for assistance with laboratory and bioinformatic work.","day":"01","isi":1,"author":[{"full_name":"Salces-Castellano, Antonia","last_name":"Salces-Castellano","first_name":"Antonia"},{"last_name":"Stankowski","id":"43161670-5719-11EA-8025-FABC3DDC885E","first_name":"Sean","full_name":"Stankowski, Sean"},{"first_name":"Paula","last_name":"Arribas","full_name":"Arribas, Paula"},{"full_name":"Patino, Jairo","first_name":"Jairo","last_name":"Patino"},{"last_name":"Karger","first_name":"Dirk N. ","full_name":"Karger, Dirk N. "},{"first_name":"Roger","last_name":"Butlin","full_name":"Butlin, Roger"},{"full_name":"Emerson, Brent C.","first_name":"Brent C.","last_name":"Emerson"}],"publisher":"Wiley","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Long-term cloud forest response to climate warming revealed by insect speciation history"},{"department":[{"_id":"TiVo"}],"language":[{"iso":"eng"}],"type":"journal_article","publication":"Nature Reviews Neuroscience","page":"1-2","date_created":"2020-11-15T23:01:18Z","has_accepted_license":"1","volume":22,"quality_controlled":"1","external_id":{"isi":["000588256300001"],"pmid":["33173190"]},"article_type":"letter_note","article_processing_charge":"No","file":[{"relation":"main_file","content_type":"application/pdf","file_size":683634,"success":1,"checksum":"7985d7dff94c086e35b94a911d78d9ad","file_id":"9088","creator":"dernst","access_level":"open_access","file_name":"2021_NatureNeuroScience_Bozelos.pdf","date_updated":"2021-02-04T10:34:22Z","date_created":"2021-02-04T10:34:22Z"}],"isi":1,"author":[{"full_name":"Bozelos, Panagiotis","first_name":"Panagiotis","last_name":"Bozelos","id":"52e9c652-2982-11eb-81d4-b43d94c63700"},{"full_name":"Vogels, Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels","first_name":"Tim P","orcid":"0000-0003-3295-6181"}],"day":"01","pmid":1,"title":"Talking science, online","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Springer Nature","date_published":"2021-01-01T00:00:00Z","oa_version":"Published Version","doi":"10.1038/s41583-020-00408-6","publication_status":"published","citation":{"apa":"Bozelos, P., &#38; Vogels, T. P. (2021). Talking science, online. <i>Nature Reviews Neuroscience</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41583-020-00408-6\">https://doi.org/10.1038/s41583-020-00408-6</a>","ista":"Bozelos P, Vogels TP. 2021. Talking science, online. Nature Reviews Neuroscience. 22(1), 1–2.","mla":"Bozelos, Panagiotis, and Tim P. Vogels. “Talking Science, Online.” <i>Nature Reviews Neuroscience</i>, vol. 22, no. 1, Springer Nature, 2021, pp. 1–2, doi:<a href=\"https://doi.org/10.1038/s41583-020-00408-6\">10.1038/s41583-020-00408-6</a>.","chicago":"Bozelos, Panagiotis, and Tim P Vogels. “Talking Science, Online.” <i>Nature Reviews Neuroscience</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41583-020-00408-6\">https://doi.org/10.1038/s41583-020-00408-6</a>.","short":"P. Bozelos, T.P. Vogels, Nature Reviews Neuroscience 22 (2021) 1–2.","ieee":"P. Bozelos and T. P. Vogels, “Talking science, online,” <i>Nature Reviews Neuroscience</i>, vol. 22, no. 1. Springer Nature, pp. 1–2, 2021.","ama":"Bozelos P, Vogels TP. Talking science, online. <i>Nature Reviews Neuroscience</i>. 2021;22(1):1-2. doi:<a href=\"https://doi.org/10.1038/s41583-020-00408-6\">10.1038/s41583-020-00408-6</a>"},"intvolume":"        22","ddc":["570"],"file_date_updated":"2021-02-04T10:34:22Z","scopus_import":"1","_id":"8757","year":"2021","abstract":[{"text":"Traditional scientific conferences and seminar events have been hugely disrupted by the COVID-19 pandemic, paving the way for virtual forms of scientific communication to take hold and be put to the test.","lang":"eng"}],"issue":"1","date_updated":"2023-08-04T11:10:20Z","month":"01","oa":1,"publication_identifier":{"eissn":["14710048"],"issn":["1471003X"]},"status":"public"},{"project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"}],"isi":1,"author":[{"id":"70B7FDF6-608D-11E9-9333-8535E6697425","last_name":"Brown","first_name":"Adam","full_name":"Brown, Adam"},{"last_name":"Romanov","first_name":"Anna","full_name":"Romanov, Anna"}],"acknowledgement":"We would like to thank Peter Trapa for useful discussions, and Dragan Milicic and Arun Ram for valuable feedback on the structure of the paper. The first author acknowledges the support of the European Unions Horizon 2020 research and innovation programme under the Marie Skodowska-Curie Grant Agreement No. 754411. The second author is\r\nsupported by the National Science Foundation Award No. 1803059.","day":"01","publisher":"American Mathematical Society","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Contravariant forms on Whittaker modules","type":"journal_article","language":[{"iso":"eng"}],"department":[{"_id":"HeEd"}],"date_created":"2020-11-19T10:17:40Z","page":"37-52","publication":"Proceedings of the American Mathematical Society","external_id":{"isi":["000600416300004"],"arxiv":["1910.08286"]},"keyword":["Applied Mathematics","General Mathematics"],"volume":149,"quality_controlled":"1","article_type":"original","article_processing_charge":"No","_id":"8773","date_updated":"2023-08-04T11:11:47Z","abstract":[{"text":"Let g be a complex semisimple Lie algebra. We give a classification of contravariant forms on the nondegenerate Whittaker g-modules Y(χ,η) introduced by Kostant. We prove that the set of all contravariant forms on Y(χ,η) forms a vector space whose dimension is given by the cardinality of the Weyl group of g. We also describe a procedure for parabolically inducing contravariant forms. As a corollary, we deduce the existence of the Shapovalov form on a Verma module, and provide a formula for the dimension of the space of contravariant forms on the degenerate Whittaker modules M(χ,η) introduced by McDowell.","lang":"eng"}],"arxiv":1,"issue":"1","year":"2021","month":"01","ec_funded":1,"status":"public","publication_identifier":{"eissn":["1088-6826"],"issn":["0002-9939"]},"oa":1,"oa_version":"Preprint","date_published":"2021-01-01T00:00:00Z","publication_status":"published","doi":"10.1090/proc/15205","intvolume":"       149","citation":{"ama":"Brown A, Romanov A. Contravariant forms on Whittaker modules. <i>Proceedings of the American Mathematical Society</i>. 2021;149(1):37-52. doi:<a href=\"https://doi.org/10.1090/proc/15205\">10.1090/proc/15205</a>","ieee":"A. Brown and A. Romanov, “Contravariant forms on Whittaker modules,” <i>Proceedings of the American Mathematical Society</i>, vol. 149, no. 1. American Mathematical Society, pp. 37–52, 2021.","short":"A. Brown, A. Romanov, Proceedings of the American Mathematical Society 149 (2021) 37–52.","chicago":"Brown, Adam, and Anna Romanov. “Contravariant Forms on Whittaker Modules.” <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society, 2021. <a href=\"https://doi.org/10.1090/proc/15205\">https://doi.org/10.1090/proc/15205</a>.","ista":"Brown A, Romanov A. 2021. Contravariant forms on Whittaker modules. Proceedings of the American Mathematical Society. 149(1), 37–52.","mla":"Brown, Adam, and Anna Romanov. “Contravariant Forms on Whittaker Modules.” <i>Proceedings of the American Mathematical Society</i>, vol. 149, no. 1, American Mathematical Society, 2021, pp. 37–52, doi:<a href=\"https://doi.org/10.1090/proc/15205\">10.1090/proc/15205</a>.","apa":"Brown, A., &#38; Romanov, A. (2021). Contravariant forms on Whittaker modules. <i>Proceedings of the American Mathematical Society</i>. American Mathematical Society. <a href=\"https://doi.org/10.1090/proc/15205\">https://doi.org/10.1090/proc/15205</a>"},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1910.08286"}]}]