@article{724,
  abstract     = {We investigate the stationary and dynamical behavior of an Anderson localized chain coupled to a single central bound state. Although this coupling partially dilutes the Anderson localized peaks towards nearly resonant sites, the most weight of the original peaks remains unchanged. This leads to multifractal wave functions with a frozen spectrum of fractal dimensions, which is characteristic for localized phases in models with power-law hopping. Using a perturbative approach we identify two different dynamical regimes. At weak couplings to the central site, the transport of particles and information is logarithmic in time, a feature usually attributed to many-body localization. We connect such transport to the persistence of the Poisson statistics of level spacings in parts of the spectrum. In contrast, at stronger couplings the level repulsion is established in the entire spectrum, the problem can be mapped to the Fano resonance, and the transport is ballistic.},
  author       = {Hetterich, Daniel and Serbyn, Maksym and Domínguez, Fernando and Pollmann, Frank and Trauzettel, Björn},
  issn         = {24699950},
  journal      = {Physical Review B},
  number       = {10},
  publisher    = {American Physical Society},
  title        = {{Noninteracting central site model localization and logarithmic entanglement growth}},
  doi          = {10.1103/PhysRevB.96.104203},
  volume       = {96},
  year         = {2017},
}

@article{725,
  abstract     = {Individual computations and social interactions underlying collective behavior in groups of animals are of great ethological, behavioral, and theoretical interest. While complex individual behaviors have successfully been parsed into small dictionaries of stereotyped behavioral modes, studies of collective behavior largely ignored these findings; instead, their focus was on inferring single, mode-independent social interaction rules that reproduced macroscopic and often qualitative features of group behavior. Here, we bring these two approaches together to predict individual swimming patterns of adult zebrafish in a group. We show that fish alternate between an “active” mode, in which they are sensitive to the swimming patterns of conspecifics, and a “passive” mode, where they ignore them. Using a model that accounts for these two modes explicitly, we predict behaviors of individual fish with high accuracy, outperforming previous approaches that assumed a single continuous computation by individuals and simple metric or topological weighing of neighbors’ behavior. At the group level, switching between active and passive modes is uncorrelated among fish, but correlated directional swimming behavior still emerges. Our quantitative approach for studying complex, multi-modal individual behavior jointly with emergent group behavior is readily extensible to additional behavioral modes and their neural correlates as well as to other species.},
  author       = {Harpaz, Roy and Tkacik, Gasper and Schneidman, Elad},
  issn         = {00278424},
  journal      = {PNAS},
  number       = {38},
  pages        = {10149 -- 10154},
  publisher    = {National Academy of Sciences},
  title        = {{Discrete modes of social information processing predict individual behavior of fish in a group}},
  doi          = {10.1073/pnas.1703817114},
  volume       = {114},
  year         = {2017},
}

@article{726,
  abstract     = {The morphogenesis of branched organs remains a subject of abiding interest. Although much is known about the underlying signaling pathways, it remains unclear how macroscopic features of branched organs, including their size, network topology, and spatial patterning, are encoded. Here, we show that, in mouse mammary gland, kidney, and human prostate, these features can be explained quantitatively within a single unifying framework of branching and annihilating random walks. Based on quantitative analyses of large-scale organ reconstructions and proliferation kinetics measurements, we propose that morphogenesis follows from the proliferative activity of equipotent tips that stochastically branch and randomly explore their environment but compete neutrally for space, becoming proliferatively inactive when in proximity with neighboring ducts. These results show that complex branched epithelial structures develop as a self-organized process, reliant upon a strikingly simple but generic rule, without recourse to a rigid and deterministic sequence of genetically programmed events.},
  author       = {Hannezo, Edouard B and Scheele, Colinda and Moad, Mohammad and Drogo, Nicholas and Heer, Rakesh and Sampogna, Rosemary and Van Rheenen, Jacco and Simons, Benjamin},
  issn         = {00928674},
  journal      = {Cell},
  number       = {1},
  pages        = {242 -- 255},
  publisher    = {Cell Press},
  title        = {{A unifying theory of branching morphogenesis}},
  doi          = {10.1016/j.cell.2017.08.026},
  volume       = {171},
  year         = {2017},
}

@article{7289,
  abstract     = {Aprotic sodium–O2 batteries require the reversible formation/dissolution of sodium superoxide (NaO2) on cycling. Poor cycle life has been associated with parasitic chemistry caused by the reactivity of electrolyte and electrode with NaO2, a strong nucleophile and base. Its reactivity can, however, not consistently explain the side reactions and irreversibility. Herein we show that singlet oxygen (1O2) forms at all stages of cycling and that it is a main driver for parasitic chemistry. It was detected in‐ and ex‐situ via a 1O2 trap that selectively and rapidly forms a stable adduct with 1O2. The 1O2 formation mechanism involves proton‐mediated superoxide disproportionation on discharge, rest, and charge below ca. 3.3 V, and direct electrochemical 1O2 evolution above ca. 3.3 V. Trace water, which is needed for high capacities also drives parasitic chemistry. Controlling the highly reactive singlet oxygen is thus crucial for achieving highly reversible cell operation.},
  author       = {Schafzahl, Lukas and Mahne, Nika and Schafzahl, Bettina and Wilkening, Martin and Slugovc, Christian and Borisov, Sergey M. and Freunberger, Stefan Alexander},
  issn         = {1433-7851},
  journal      = {Angewandte Chemie International Edition},
  number       = {49},
  pages        = {15728--15732},
  publisher    = {Wiley},
  title        = {{Singlet oxygen during cycling of the aprotic sodium-O2 battery}},
  doi          = {10.1002/anie.201709351},
  volume       = {56},
  year         = {2017},
}

@article{7290,
  abstract     = {We report a family of Pt and Pd benzoporphyrin dyes with versatile photophysical properties and easy access from cheap and abundant chemicals. Attaching 4 or 8 alkylsulfone groups onto a meso-tetraphenyltetrabenzoporphyrin (TPTBP) macrocylcle renders the dyes highly soluble in organic solvents, photostable, and electron-deficient with the redox potential raised up to 0.65 V versus the parent porphyrin. The new dyes intensively absorb in the blue (Soret band, 440–480 nm) and in the red (Q-band, 620–650 nm) parts of the electromagnetic spectrum and show bright phosphorescence at room-temperature in the NIR with quantum yields up to 30% in solution. The small singlet–triplet energy gap yields unusually efficient thermally activated delayed fluorescence (TADF) at elevated temperatures in solution and in polymeric matrices with quantum yields as high as 27% at 120 °C, which is remarkable for benzoporphyrins. Apart from oxygen sensing, these properties enable unprecedented simultaneous, self-referenced oxygen and temperature sensing with a single indicator dye: whereas oxygen can be determined either via the decay time of phosphorescence or TADF, the temperature is accessed via the ratio of the two emissions. Moreover, the dyes are efficient sensitizers for triplet–triplet annihilation (TTA)-based upconversion making possible longer sensitization wavelength than the conventional benzoporphyrin complexes. The Pt-octa-sulfone dye also features interesting semireversible transformation in basic media, which generates new NIR absorbing species.},
  author       = {Zach, Peter W. and Freunberger, Stefan Alexander and Klimant, Ingo and Borisov, Sergey M.},
  issn         = {1944-8252},
  journal      = {ACS Applied Materials & Interfaces},
  number       = {43},
  pages        = {38008--38023},
  publisher    = {ACS},
  title        = {{Electron-deficient near-infrared Pt(II) and Pd(II) benzoporphyrins with dual phosphorescence and unusually efficient thermally activated delayed fluorescence: First demonstration of simultaneous oxygen and temperature sensing with a single emitter}},
  doi          = {10.1021/acsami.7b10669},
  volume       = {9},
  year         = {2017},
}

@article{7292,
  abstract     = {Rechargeable Li–O2 batteries have amongst the highest formal energy and could store significantly more energy than other rechargeable batteries in practice if at least a large part of their promise could be realized. Realization, however, still faces many challenges than can only be overcome by fundamental understanding of the processes taking place. Here, we review recent advances in understanding the chemistry of the Li–O2 cathode and provide a perspective on dominant research needs. We put particular emphasis on issues that are often grossly misunderstood: realistic performance metrics and their reporting as well as identifying reversibility and quantitative measures to do so. Parasitic reactions are the prime obstacle for reversible cell operation and have recently been identified to be predominantly caused by singlet oxygen and not by reduced oxygen species as thought before. We discuss the far reaching implications of this finding on electrolyte and cathode stability, electrocatalysis, and future research needs.},
  author       = {Mahne, Nika and Fontaine, Olivier and Thotiyl, Musthafa Ottakam and Wilkening, Martin and Freunberger, Stefan Alexander},
  issn         = {2041-6539},
  journal      = {Chemical Science},
  number       = {10},
  pages        = {6716--6729},
  publisher    = {RSC},
  title        = {{Mechanism and performance of lithium–oxygen batteries – a perspective}},
  doi          = {10.1039/c7sc02519j},
  volume       = {8},
  year         = {2017},
}

@article{732,
  abstract     = {Background: Social insects form densely crowded societies in environments with high pathogen loads, but have evolved collective defences that mitigate the impact of disease. However, colony-founding queens lack this protection and suffer high rates of mortality. The impact of pathogens may be exacerbated in species where queens found colonies together, as healthy individuals may contract pathogens from infectious co-founders. Therefore, we tested whether ant queens avoid founding colonies with pathogen-exposed conspecifics and how they might limit disease transmission from infectious individuals. Results: Using Lasius Niger queens and a naturally infecting fungal pathogen Metarhizium brunneum, we observed that queens were equally likely to found colonies with another pathogen-exposed or sham-treated queen. However, when one queen died, the surviving individual performed biting, burial and removal of the corpse. These undertaking behaviours were performed prophylactically, i.e. targeted equally towards non-infected and infected corpses, as well as carried out before infected corpses became infectious. Biting and burial reduced the risk of the queens contracting and dying from disease from an infectious corpse of a dead co-foundress. Conclusions: We show that co-founding ant queens express undertaking behaviours that, in mature colonies, are performed exclusively by workers. Such infection avoidance behaviours act before the queens can contract the disease and will therefore improve the overall chance of colony founding success in ant queens.},
  author       = {Pull, Christopher and Cremer, Sylvia},
  issn         = {14712148},
  journal      = {BMC Evolutionary Biology},
  number       = {1},
  publisher    = {BioMed Central},
  title        = {{Co-founding ant queens prevent disease by performing prophylactic undertaking behaviour}},
  doi          = {10.1186/s12862-017-1062-4},
  volume       = {17},
  year         = {2017},
}

@article{733,
  abstract     = {Let A and B be two N by N deterministic Hermitian matrices and let U be an N by N Haar distributed unitary matrix. It is well known that the spectral distribution of the sum H = A + UBU∗ converges weakly to the free additive convolution of the spectral distributions of A and B, as N tends to infinity. We establish the optimal convergence rate in the bulk of the spectrum.},
  author       = {Bao, Zhigang and Erdös, László and Schnelli, Kevin},
  journal      = {Advances in Mathematics},
  pages        = {251 -- 291},
  publisher    = {Academic Press},
  title        = {{Convergence rate for spectral distribution of addition of random matrices}},
  doi          = {10.1016/j.aim.2017.08.028},
  volume       = {319},
  year         = {2017},
}

@article{734,
  abstract     = {Social insect societies are long-standing models for understanding social behaviour and evolution. Unlike other advanced biological societies (such as the multicellular body), the component parts of social insect societies can be easily deconstructed and manipulated. Recent methodological and theoretical innovations have exploited this trait to address an expanded range of biological questions. We illustrate the broadening range of biological insight coming from social insect biology with four examples. These new frontiers promote open-minded, interdisciplinary exploration of one of the richest and most complex of biological phenomena: sociality.},
  author       = {Kennedy, Patrick and Baron, Gemma and Qiu, Bitao and Freitak, Dalial and Helantera, Heikki and Hunt, Edmund and Manfredini, Fabio and O'Shea Wheller, Thomas and Patalano, Solenn and Pull, Christopher and Sasaki, Takao and Taylor, Daisy and Wyatt, Christopher and Sumner, Seirian},
  issn         = {01695347},
  journal      = {Trends in Ecology and Evolution},
  number       = {11},
  pages        = {861 -- 872},
  publisher    = {Cell Press},
  title        = {{Deconstructing superorganisms and societies to address big questions in biology}},
  doi          = {10.1016/j.tree.2017.08.004},
  volume       = {32},
  year         = {2017},
}

@article{736,
  abstract     = {The neurotransmitter receptor subtype, number, density, and distribution relative to the location of transmitter release sites are key determinants of signal transmission. AMPA-type ionotropic glutamate receptors (AMPARs) containing GluA3 and GluA4 subunits are prominently expressed in subsets of neurons capable of firing action potentials at high frequencies, such as auditory relay neurons. The auditory nerve (AN) forms glutamatergic synapses on two types of relay neurons, bushy cells (BCs) and fusiform cells (FCs) of the cochlear nucleus. AN-BC and AN-FC synapses have distinct kinetics; thus, we investigated whether the number, density, and localization of GluA3 and GluA4 subunits in these synapses are differentially organized using quantitative freeze-fracture replica immunogold labeling. We identify a positive correlation between the number of AMPARs and the size of AN-BC and AN-FC synapses. Both types of AN synapses have similar numbers of AMPARs; however, the AN-BC have a higher density of AMPARs than AN-FC synapses, because the AN-BC synapses are smaller. A higher number and density of GluA3 subunits are observed at AN-BC synapses, whereas a higher number and density of GluA4 subunits are observed at AN-FC synapses. The intrasynaptic distribution of immunogold labeling revealed that AMPAR subunits, particularly GluA3, are concentrated at the center of the AN-BC synapses. The central distribution of AMPARs is absent in GluA3-knockout mice, and gold particles are evenly distributed along the postsynaptic density. GluA4 gold labeling was homogenously distributed along both synapse types. Thus, GluA3 and GluA4 subunits are distributed at AN synapses in a target-cell-dependent manner.},
  author       = {Rubio, María and Matsui, Ko and Fukazawa, Yugo and Kamasawa, Naomi and Harada, Harumi and Itakura, Makoto and Molnár, Elek and Abe, Manabu and Sakimura, Kenji and Shigemoto, Ryuichi},
  issn         = {18632653},
  journal      = {Brain Structure and Function},
  number       = {8},
  pages        = {3375 -- 3393},
  publisher    = {Springer},
  title        = {{The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells}},
  doi          = {10.1007/s00429-017-1408-0},
  volume       = {222},
  year         = {2017},
}

@article{7360,
  abstract     = {Inflammation, which is a highly regulated host response against danger signals, may be harmful if it is excessive and deregulated. Ideally, anti-inflammatory therapy should autonomously commence as soon as possible after the onset of inflammation, should be controllable by a physician, and should not systemically block beneficial immune response in the long term. We describe a genetically encoded anti-inflammatory mammalian cell device based on a modular engineered genetic circuit comprising a sensor, an amplifier, a “thresholder” to restrict activation of a positive-feedback loop, a combination of advanced clinically used biopharmaceutical proteins, and orthogonal regulatory elements that linked modules into the functional device. This genetic circuit was autonomously activated by inflammatory signals, including endogenous cecal ligation and puncture (CLP)-induced inflammation in mice and serum from a systemic juvenile idiopathic arthritis (sIJA) patient, and could be reset externally by a chemical signal. The microencapsulated anti-inflammatory device significantly reduced the pathology in dextran sodium sulfate (DSS)-induced acute murine colitis, demonstrating a synthetic immunological approach for autonomous anti-inflammatory therapy.},
  author       = {Smole, Anže and Lainšček, Duško and Bezeljak, Urban and Horvat, Simon and Jerala, Roman},
  issn         = {1525-0016},
  journal      = {Molecular Therapy},
  number       = {1},
  pages        = {102--119},
  publisher    = {Elsevier},
  title        = {{A synthetic mammalian therapeutic gene circuit for sensing and suppressing inflammation}},
  doi          = {10.1016/j.ymthe.2016.10.005},
  volume       = {25},
  year         = {2017},
}

@article{739,
  abstract     = {We study the norm approximation to the Schrödinger dynamics of N bosons in with an interaction potential of the form . Assuming that in the initial state the particles outside of the condensate form a quasi-free state with finite kinetic energy, we show that in the large N limit, the fluctuations around the condensate can be effectively described using Bogoliubov approximation for all . The range of β is expected to be optimal for this large class of initial states.},
  author       = {Nam, Phan and Napiórkowski, Marcin M},
  issn         = {00217824},
  journal      = {Journal de Mathématiques Pures et Appliquées},
  number       = {5},
  pages        = {662 -- 688},
  publisher    = {Elsevier},
  title        = {{A note on the validity of Bogoliubov correction to mean field dynamics}},
  doi          = {10.1016/j.matpur.2017.05.013},
  volume       = {108},
  year         = {2017},
}

@article{740,
  abstract     = {Developments in bioengineering and molecular biology have introduced a palette of genetically encoded probes for identification of specific cell populations in electron microscopy. These probes can be targeted to distinct cellular compartments, rendering them electron dense through a subsequent chemical reaction. These electron densities strongly increase the local contrast in samples prepared for electron microscopy, allowing three major advances in ultrastructural mapping of circuits: genetic identification of circuit components, targeted imaging of regions of interest and automated analysis of the tagged circuits. Together, the gains from these advances can decrease the time required for the analysis of targeted circuit motifs by over two orders of magnitude. These genetic encoded tags for electron microscopy promise to simplify the analysis of circuit motifs and become a central tool for structure‐function studies of synaptic connections in the brain. We review the current state‐of‐the‐art with an emphasis on connectomics, the quantitative analysis of neuronal structures and motifs.},
  author       = {Shigemoto, Ryuichi and Jösch, Maximilian A},
  issn         = {17597684},
  journal      = {WIREs Developmental Biology},
  number       = {6},
  publisher    = {Wiley-Blackwell},
  title        = {{The genetic encoded toolbox for electron microscopy and connectomics}},
  doi          = {10.1002/wdev.288},
  volume       = {6},
  year         = {2017},
}

@article{741,
  abstract     = {We prove that a system of N fermions interacting with an additional particle via point interactions is stable if the ratio of the mass of the additional particle to the one of the fermions is larger than some critical m*. The value of m* is independent of N and turns out to be less than 1. This fact has important implications for the stability of the unitary Fermi gas. We also characterize the domain of the Hamiltonian of this model, and establish the validity of the Tan relations for all wave functions in the domain.},
  author       = {Moser, Thomas and Seiringer, Robert},
  issn         = {00103616},
  journal      = {Communications in Mathematical Physics},
  number       = {1},
  pages        = {329 -- 355},
  publisher    = {Springer},
  title        = {{Stability of a fermionic N+1 particle system with point interactions}},
  doi          = {10.1007/s00220-017-2980-0},
  volume       = {356},
  year         = {2017},
}

@article{744,
  abstract     = {In evolutionary game theory interactions between individuals are often assumed obligatory. However, in many real-life situations, individuals can decide to opt out of an interaction depending on the information they have about the opponent. We consider a simple evolutionary game theoretic model to study such a scenario, where at each encounter between two individuals the type of the opponent (cooperator/defector) is known with some probability, and where each individual either accepts or opts out of the interaction. If the type of the opponent is unknown, a trustful individual accepts the interaction, whereas a suspicious individual opts out of the interaction. If either of the two individuals opt out both individuals remain without an interaction. We show that in the prisoners dilemma optional interactions along with suspicious behaviour facilitates the emergence of trustful cooperation.},
  author       = {Priklopil, Tadeas and Chatterjee, Krishnendu and Nowak, Martin},
  issn         = {00225193},
  journal      = { Journal of Theoretical Biology},
  pages        = {64 -- 72},
  publisher    = {Elsevier},
  title        = {{Optional interactions and suspicious behaviour facilitates trustful cooperation in prisoners dilemma}},
  doi          = {10.1016/j.jtbi.2017.08.025},
  volume       = {433},
  year         = {2017},
}

@article{745,
  abstract     = {Fluid flows in nature and applications are frequently subject to periodic velocity modulations. Surprisingly, even for the generic case of flow through a straight pipe, there is little consensus regarding the influence of pulsation on the transition threshold to turbulence: while most studies predict a monotonically increasing threshold with pulsation frequency (i.e. Womersley number, ), others observe a decreasing threshold for identical parameters and only observe an increasing threshold at low . In the present study we apply recent advances in the understanding of transition in steady shear flows to pulsating pipe flow. For moderate pulsation amplitudes we find that the first instability encountered is subcritical (i.e. requiring finite amplitude disturbances) and gives rise to localized patches of turbulence ('puffs') analogous to steady pipe flow. By monitoring the impact of pulsation on the lifetime of turbulence we map the onset of turbulence in parameter space. Transition in pulsatile flow can be separated into three regimes. At small Womersley numbers the dynamics is dominated by the decay turbulence suffers during the slower part of the cycle and hence transition is delayed significantly. As shown in this regime thresholds closely agree with estimates based on a quasi-steady flow assumption only taking puff decay rates into account. The transition point predicted in the zero limit equals to the critical point for steady pipe flow offset by the oscillation Reynolds number (i.e. the dimensionless oscillation amplitude). In the high frequency limit on the other hand, puff lifetimes are identical to those in steady pipe flow and hence the transition threshold appears to be unaffected by flow pulsation. In the intermediate frequency regime the transition threshold sharply drops (with increasing ) from the decay dominated (quasi-steady) threshold to the steady pipe flow level.},
  author       = {Xu, Duo and Warnecke, Sascha and Song, Baofang and Ma, Xingyu and Hof, Björn},
  issn         = {00221120},
  journal      = {Journal of Fluid Mechanics},
  pages        = {418 -- 432},
  publisher    = {Cambridge University Press},
  title        = {{Transition to turbulence in pulsating pipe flow}},
  doi          = {10.1017/jfm.2017.620},
  volume       = {831},
  year         = {2017},
}

@article{746,
  abstract     = {Metabotropic glutamate receptor subtype 5 (mGluR5) is crucially implicated in the pathophysiology of Fragile X Syndrome (FXS); however, its dysfunction at the sub-cellular level, and related synaptic and cognitive phenotypes are unexplored. Here, we probed the consequences of mGluR5/Homer scaffold disruption for mGluR5 cell-surface mobility, synaptic N-methyl-D-Aspartate receptor (NMDAR) function, and behavioral phenotypes in the second-generation Fmr1 knockout (KO) mouse. Using single-molecule tracking, we found that mGluR5 was significantly more mobile at synapses in hippocampal Fmr1 KO neurons, causing an increased synaptic surface co-clustering of mGluR5 and NMDAR. This correlated with a reduced amplitude of synaptic NMDAR currents, a lack of their mGluR5-Activated long-Term depression, and NMDAR/hippocampus dependent cognitive deficits. These synaptic and behavioral phenomena were reversed by knocking down Homer1a in Fmr1 KO mice. Our study provides a mechanistic link between changes of mGluR5 dynamics and pathological phenotypes of FXS, unveiling novel targets for mGluR5-based therapeutics.},
  author       = {Aloisi, Elisabetta and Le Corf, Katy and Dupuis, Julien and Zhang, Pei and Ginger, Melanie and Labrousse, Virginie and Spatuzza, Michela and Georg Haberl, Matthias and Costa, Lara and Shigemoto, Ryuichi and Tappe Theodor, Anke and Drago, Fillippo and Vincenzo Piazza, Pier and Mulle, Christophe and Groc, Laurent and Ciranna, Lucia and Catania, Maria and Frick, Andreas},
  issn         = {20411723},
  journal      = {Nature Communications},
  number       = {1},
  publisher    = {Nature Publishing Group},
  title        = {{Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice}},
  doi          = {10.1038/s41467-017-01191-2},
  volume       = {8},
  year         = {2017},
}

@article{747,
  abstract     = {Bradykinin (BK), a component of the kallikrein-kininogen-kinin system exerts multiple effects via B1 and B2 receptor activation. In the cardiovascular system, bradykinin has cardioprotective and vasodilator properties. We investigated the effect of BK on cardiac-projecting neurons of nucleus ambiguus, a key site for the parasympathetic cardiac regulation. BK produced a dose-dependent increase in cytosolic Ca2+ concentration. Pretreatment with HOE140, a B2 receptor antagonist, but not with R715, a B1 receptor antagonist, abolished the response to BK. A selective B2 receptor agonist, but not a B1 receptor agonist, elicited an increase in cytosolic Ca2+ similarly to BK. Inhibition of N-type voltage-gated Ca2+ channels with ω-conotoxin GVIA had no effect on the Ca2+ signal produced by BK, while pretreatment with ω-conotoxin MVIIC, a blocker of P/Q-type of Ca2+ channels, significantly diminished the effect of BK. Pretreatment with xestospongin C and 2-aminoethoxydiphenyl borate, antagonists of inositol 1,4,5-trisphosphate receptors, abolished the response to BK. Inhibition of ryanodine receptors reduced the BK-induced Ca2+ increase, while disruption of lysosomal Ca2+ stores with bafilomycin A1 did not affect the response. BK produced a dose-dependent depolarization of nucleus ambiguus neurons, which was prevented by the B2 receptor antagonist. In vivo studies indicate that microinjection of BK into nucleus ambiguus elicited bradycardia in conscious rats via B2 receptors. In summary, in cardiac vagal neurons of nucleus ambiguus, BK activates B2 receptors promoting Ca2+ influx and Ca2+ release from endoplasmic reticulum, and membrane depolarization; these effects are translated in vivo by bradycardia.},
  author       = {Brǎiloiu, Eugen and Mcguire, Matthew and Shuler, Shadaria and Deliu, Elena and Barr, Jeffrey and Abood, Mary and Brailoiu, Gabriela},
  issn         = {03064522},
  journal      = {Neuroscience},
  pages        = {23 -- 32},
  publisher    = {Elsevier},
  title        = {{Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus}},
  doi          = {10.1016/j.neuroscience.2017.09.034},
  volume       = {365},
  year         = {2017},
}

@article{749,
  abstract     = {Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly expressed in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output synapses of these neurons produce only minimal asynchronous release and show depression rather than facilitation. To resolve this apparent contradiction, we examined the effects of genetic elimination of Syt7 on synaptic transmission at the GABAergic basket cell (BC)-Purkinje cell (PC) synapse in cerebellum. Our results indicate that at the BC-PC synapse, Syt7 contributes to asynchronous release, pool replenishment, and facilitation. In combination, these three effects ensure efficient transmitter release during high-frequency activity and guarantee frequency independence of inhibition. Our results identify a distinct function of Syt7: ensuring the efficiency of high-frequency inhibitory synaptic transmission},
  author       = {Chen, Chong and Satterfield, Rachel and Young, Samuel and Jonas, Peter M},
  issn         = {22111247},
  journal      = {Cell Reports},
  number       = {8},
  pages        = {2082 -- 2089},
  publisher    = {Cell Press},
  title        = {{Triple function of Synaptotagmin 7 ensures efficiency of high-frequency transmission at central GABAergic synapses}},
  doi          = {10.1016/j.celrep.2017.10.122},
  volume       = {21},
  year         = {2017},
}

@article{751,
  abstract     = {The basement membrane (BM) is a thin layer of extracellular matrix (ECM) beneath nearly all epithelial cell types that is critical for cellular and tissue function. It is composed of numerous components conserved among all bilaterians [1]; however, it is unknown how all of these components are generated and subsequently constructed to form a fully mature BM in the living animal. Although BM formation is thought to simply involve a process of self-assembly [2], this concept suffers from a number of logistical issues when considering its construction in vivo. First, incorporation of BM components appears to be hierarchical [3-5], yet it is unclear whether their production during embryogenesis must also be regulated in a temporal fashion. Second, many BM proteins are produced not only by the cells residing on the BM but also by surrounding cell types [6-9], and it is unclear how large, possibly insoluble protein complexes [10] are delivered into the matrix. Here we exploit our ability to live image and genetically dissect de novo BM formation during Drosophila development. This reveals that there is a temporal hierarchy of BM protein production that is essential for proper component incorporation. Furthermore, we show that BM components require secretion by migrating macrophages (hemocytes) during their developmental dispersal, which is critical for embryogenesis. Indeed, hemocyte migration is essential to deliver a subset of ECM components evenly throughout the embryo. This reveals that de novo BM construction requires a combination of both production and distribution logistics allowing for the timely delivery of core components.},
  author       = {Matsubayashi, Yutaka and Louani, Adam and Dragu, Anca and Sanchez Sanchez, Besaiz and Serna Morales, Eduardo and Yolland, Lawrence and György, Attila and Vizcay, Gema and Fleck, Roland and Heddleston, John and Chew, Teng and Siekhaus, Daria E and Stramer, Brian},
  issn         = {09609822},
  journal      = {Current Biology},
  number       = {22},
  pages        = {3526 -- 3534e.4},
  publisher    = {Cell Press},
  title        = {{A moving source of matrix components is essential for De Novo basement membrane formation}},
  doi          = {10.1016/j.cub.2017.10.001},
  volume       = {27},
  year         = {2017},
}