@article{12595, abstract = {The seasonal dynamic changes of Tibetan glaciers have seen little prior investigation, despite the increase in geodetic studies of multi-year changes. This study compares seasonal glacier dynamics (“cold” and “warm” seasons) in the ablation zone of Parlung No. 4 Glacier, a temperate glacier in the monsoon-influenced southeastern Tibetan Plateau, by using repeat unpiloted aerial vehicle (UAV) surveys combined with Structure-from-Motion (SfM) photogrammetry and ground stake measurements. Our results showed that the surveyed ablation zone had a mean change of −2.7 m of ice surface elevation during the period of September 2018 to October 2019 but is characterized by significant seasonal cyclic variations with ice surface elevation lifting (+2.0 m) in the cold season (September 2018 to June 2019) but lowering (−4.7 m) in the warm season (June 2019 to October 2019). Over an annual timescale, surface lowering was greatly suppressed by the resupply of ice from the glacier’s accumulation area—the annual emergence velocity compensates for about 55% of surface ablation in our study area. Cold season emergence velocities (3.0 ± 1.2 m) were ~5-times larger than those observed in the warm season (0.6 ± 1.0 m). Distinct spring precipitation patterns may contribute to these distinct seasonal signals. Such seasonal dynamic conditions are possibly critical for different glacier responses to climate change in this region of the Tibetan Plateau, and perhaps further afield.}, author = {Yang, Wei and Zhao, Chuanxi and Westoby, Matthew and Yao, Tandong and Wang, Yongjie and Pellicciotti, Francesca and Zhou, Jianmin and He, Zhen and Miles, Evan}, issn = {2072-4292}, journal = {Remote Sensing}, number = {15}, publisher = {MDPI}, title = {{Seasonal dynamics of a temperate Tibetan glacier revealed by high-resolution UAV photogrammetry and in situ measurements}}, doi = {10.3390/rs12152389}, volume = {12}, year = {2020}, } @article{12596, abstract = {As glaciers adjust their size in response to climate variations, long-term changes in meltwater production can be expected, affecting the local availability of water resources. We investigate glacier runoff in the period 1955–2016 in the Maipo River basin (4843 km2, 33.0–34.3∘ S, 69.8–70.5∘ W), in the semiarid Andes of Chile. The basin contains more than 800 glaciers, which cover 378 km2 in total (inventoried in 2000). We model the mass balance and runoff contribution of 26 glaciers with the physically oriented and fully distributed TOPKAPI (Topographic Kinematic Approximation and Integration)-ETH glacio-hydrological model and extrapolate the results to the entire basin. TOPKAPI-ETH is run at a daily time step using several glaciological and meteorological datasets, and its results are evaluated against streamflow records, remotely sensed snow cover, and geodetic mass balances for the periods 1955–2000 and 2000–2013. Results show that in 1955–2016 glacier mass balance had a general decreasing trend as a basin average but also had differences between the main sub-catchments. Glacier volume decreased by one-fifth (from 18.6±4.5 to 14.9±2.9 km3). Runoff from the initially glacierized areas was 177±25 mm yr−1 (16±7 % of the total contributions to the basin), but it shows a decreasing sequence of maxima, which can be linked to the interplay between a decrease in precipitation since the 1980s and the reduction of ice melt. Glaciers in the Maipo River basin will continue retreating because they are not in equilibrium with the current climate. In a hypothetical constant climate scenario, glacier volume would reduce to 81±38 % of the year 2000 volume, and glacier runoff would be 78±30 % of the 1955–2016 average. This would considerably decrease the drought mitigation capacity of the basin.}, author = {Ayala, Álvaro and Farías-Barahona, David and Huss, Matthias and Pellicciotti, Francesca and McPhee, James and Farinotti, Daniel}, issn = {1994-0424}, journal = {The Cryosphere}, keywords = {Earth-Surface Processes, Water Science and Technology}, number = {6}, pages = {2005--2027}, publisher = {Copernicus Publications}, title = {{Glacier runoff variations since 1955 in the Maipo River basin, in the semiarid Andes of central Chile}}, doi = {10.5194/tc-14-2005-2020}, volume = {14}, year = {2020}, } @article{12597, abstract = {We examine the spatial patterns of near-surface air temperature (Ta) over a melting glacier using a multi-annual dataset from McCall Glacier, Alaska. The dataset consists of a 10-year (2005–2014) meteorological record along the glacier centreline up to an upper glacier cirque, spanning an elevation difference of 900 m. We test the validity of on-glacier linear lapse rates, and a model that calculates Ta based on the influence of katabatic winds and other heat sources along the glacier flow line. During the coldest hours of each summer (10% of time), average lapse rates across the entire glacier range from −4.7 to −6.7°C km−1, with a strong relationship between Ta and elevation (R2 > 0.7). During warm conditions, Ta shows more complex, non-linear patterns that are better explained by the flow line-dependent model, reducing errors by up to 0.5°C compared with linear lapse rates, although more uncertainty might be associated with these observations due to occasionally poor sensor ventilation. We conclude that Ta spatial distribution can vary significantly from year to year, and from one glacier section to another. Importantly, extrapolations using linear lapse rates from the ablation zone might lead to large underestimations of Ta on the upper glacier areas.}, author = {Troxler, Patrick and Ayala, Álvaro and Shaw, Thomas E. and Nolan, Matt and Brock, Ben W. and Pellicciotti, Francesca}, issn = {1727-5652}, journal = {Journal of Glaciology}, keywords = {Earth-Surface Processes}, number = {257}, pages = {386--400}, publisher = {Cambridge University Press}, title = {{Modelling spatial patterns of near-surface air temperature over a decade of melt seasons on McCall Glacier, Alaska}}, doi = {10.1017/jog.2020.12}, volume = {66}, year = {2020}, } @article{12598, abstract = {Obtaining detailed information about high mountain snowpacks is often limited by insufficient ground-based observations and uncertainty in the (re)distribution of solid precipitation. We utilize high-resolution optical images from Pléiades satellites to generate a snow depth map, at a spatial resolution of 4 m, for a high mountain catchment of central Chile. Results are negatively biased (median difference of −0.22 m) when compared against observations from a terrestrial Light Detection And Ranging scan, though replicate general snow depth variability well. Additionally, the Pléiades dataset is subject to data gaps (17% of total pixels), negative values for shallow snow (12%), and noise on slopes >40–50° (2%). We correct and filter the Pléiades snow depths using surface classification techniques of snow-free areas and a random forest model for data gap filling. Snow depths (with an estimated error of ~0.36 m) average 1.66 m and relate well to topographical parameters such as elevation and northness in a similar way to previous studies. However, estimations of snow depth based upon topography (TOPO) or physically based modeling (DBSM) cannot resolve localized processes (i.e., avalanching or wind scouring) that are detected by Pléiades, even when forced with locally calibrated data. Comparing these alternative model approaches to corrected Pléiades snow depths reveals total snow volume differences between −28% (DBSM) and +54% (TOPO) for the catchment and large differences across most elevation bands. Pléiades represents an important contribution to understanding snow accumulation at sparsely monitored catchments, though ideally requires a careful systematic validation procedure to identify catchment-scale biases and errors in the snow depth derivation.}, author = {Shaw, Thomas E. and Gascoin, Simon and Mendoza, Pablo A. and Pellicciotti, Francesca and McPhee, James}, issn = {1944-7973}, journal = {Water Resources Research}, keywords = {Water Science and Technology}, number = {2}, publisher = {American Geophysical Union}, title = {{Snow depth patterns in a high mountain Andean catchment from satellite optical tristereoscopic remote sensing}}, doi = {10.1029/2019wr024880}, volume = {56}, year = {2020}, } @article{12939, abstract = {Linear tetrapyrroles, called phyllobilins, are obtained as major catabolites upon chlorophyll degradation. Primarily, colorless phylloleucobilins featuring four deconjugated pyrrole units were identified. Their yellow counterparts, phylloxanthobilins, were discovered more recently. Although the two catabolites differ only by one double bond, physicochemical properties are very distinct. Moreover, the presence of the double bond seems to enhance physiologically relevant bioactivities: in contrast to phylloleucobilin, we identified a potent anti-proliferative activity for a phylloxanthobilin, and show that this natural product induces apoptotic cell death and a cell cycle arrest in cancer cells. Interestingly, upon modifying inactive phylloleucobilin by esterification, an anti-proliferative activity can be observed that increases with the chain lengths of the alkyl esters. We provide first evidence for anti-cancer activity of phyllobilins, report a novel plant source for a phylloxanthobilin, and by using paper spray MS, show that these bioactive yellow chlorophyll catabolites are more prevalent in Nature than previously assumed.}, author = {Karg, Cornelia A. and Wang, Pengyu and Kluibenschedl, Florian and Müller, Thomas and Allmendinger, Lars and Vollmar, Angelika M. and Moser, Simone}, issn = {1434-193X}, journal = {European Journal of Organic Chemistry}, keywords = {Organic Chemistry, Physical and Theoretical Chemistry}, number = {29}, pages = {4499--4509}, publisher = {Wiley}, title = {{Phylloxanthobilins are abundant linear tetrapyrroles from chlorophyll breakdown with activities against cancer cells}}, doi = {10.1002/ejoc.202000692}, volume = {2020}, year = {2020}, } @article{12940, abstract = {Desorption electrospray ionization (DESI), easy ambient sonic-spray ionization (EASI) and low-temperature plasma (LTP) ionization are powerful ambient ionization techniques for mass spectrometry. However, every single method has its limitation in terms of polarity and molecular weight of analyte molecules. After the miniaturization of every possible component of the different ion sources, we finally were able to embed two emitters and an ion transfer tubing into a small, hand-held device. The pen-like interface is connected to the mass spectrometer and a separate control unit via a bundle of flexible tubing and cables. The novel device allows the user to ionize an extended range of chemicals by simple switching between DESI, voltage-free EASI, or LTP ionization as well as to freely move the interface over a surface of interest. A mini camera, which is mounted on the tip of the pen, magnifies the desorption area and enables a simple positioning of the pen. The interface was successfully tested using different types of chemicals, pharmaceuticals, and real life samples. Moreover, the combination of optical data from the camera module and chemical data obtained by mass analysis facilitates a novel type of imaging mass spectrometry, which we name “interactive mass spectrometry imaging (IMSI)”.}, author = {Meisenbichler, Christina and Kluibenschedl, Florian and Müller, Thomas}, issn = {0003-2700}, journal = {Analytical Chemistry}, keywords = {Analytical Chemistry}, number = {21}, pages = {14314--14318}, publisher = {American Chemical Society}, title = {{A 3-in-1 hand-held ambient mass spectrometry interface for identification and 2D localization of chemicals on surfaces}}, doi = {10.1021/acs.analchem.0c02615}, volume = {92}, year = {2020}, } @misc{13056, abstract = {This datasets comprises all data shown in plots of the submitted article "Converting microwave and telecom photons with a silicon photonic nanomechanical interface". Additional raw data are available from the corresponding author on reasonable request.}, author = {Arnold, Georg M and Wulf, Matthias and Barzanjeh, Shabir and Redchenko, Elena and Rueda Sanchez, Alfredo R and Hease, William J and Hassani, Farid and Fink, Johannes M}, publisher = {Zenodo}, title = {{Converting microwave and telecom photons with a silicon photonic nanomechanical interface}}, doi = {10.5281/ZENODO.3961561}, year = {2020}, } @misc{13060, abstract = {Coinfections with multiple pathogens can result in complex within-host dynamics affecting virulence and transmission. Whilst multiple infections are intensively studied in solitary hosts, it is so far unresolved how social host interactions interfere with pathogen competition, and if this depends on coinfection diversity. We studied how the collective disease defenses of ants – their social immunity ­– influence pathogen competition in coinfections of same or different fungal pathogen species. Social immunity reduced virulence for all pathogen combinations, but interfered with spore production only in different-species coinfections. Here, it decreased overall pathogen sporulation success, whilst simultaneously increasing co-sporulation on individual cadavers and maintaining a higher pathogen diversity at the community-level. Mathematical modeling revealed that host sanitary care alone can modulate competitive outcomes between pathogens, giving advantage to fast-germinating, thus less grooming-sensitive ones. Host social interactions can hence modulate infection dynamics in coinfected group members, thereby altering pathogen communities at the host- and population-level.}, author = {Milutinovic, Barbara and Stock, Miriam and Grasse, Anna V and Naderlinger, Elisabeth and Hilbe, Christian and Cremer, Sylvia}, publisher = {Dryad}, title = {{Social immunity modulates competition between coinfecting pathogens}}, doi = {10.5061/DRYAD.CRJDFN318}, year = {2020}, } @misc{13065, abstract = {Domestication is a human-induced selection process that imprints the genomes of domesticated populations over a short evolutionary time scale, and that occurs in a given demographic context. Reconstructing historical gene flow, effective population size changes and their timing is therefore of fundamental interest to understand how plant demography and human selection jointly shape genomic divergence during domestication. Yet, the comparison under a single statistical framework of independent domestication histories across different crop species has been little evaluated so far. Thus, it is unclear whether domestication leads to convergent demographic changes that similarly affect crop genomes. To address this question, we used existing and new transcriptome data on three crop species of Solanaceae (eggplant, pepper and tomato), together with their close wild relatives. We fitted twelve demographic models of increasing complexity on the unfolded joint allele frequency spectrum for each wild/crop pair, and we found evidence for both shared and species-specific demographic processes between species. A convergent history of domestication with gene-flow was inferred for all three species, along with evidence of strong reduction in the effective population size during the cultivation stage of tomato and pepper. The absence of any reduction in size of the crop in eggplant stands out from the classical view of the domestication process; as does the existence of a “protracted period” of management before cultivation. Our results also suggest divergent management strategies of modern cultivars among species as their current demography substantially differs. Finally, the timing of domestication is species-specific and supported by the few historical records available.}, author = {Arnoux, Stephanie and Fraisse, Christelle and Sauvage, Christopher}, publisher = {Dryad}, title = {{VCF files of synonymous SNPs related to: Genomic inference of complex domestication histories in three Solanaceae species}}, doi = {10.5061/DRYAD.Q2BVQ83HD}, year = {2020}, } @misc{13070, abstract = {This dataset comprises all data shown in the figures of the submitted article "Surpassing the resistance quantum with a geometric superinductor". Additional raw data are available from the corresponding author on reasonable request.}, author = {Peruzzo, Matilda and Trioni, Andrea and Hassani, Farid and Zemlicka, Martin and Fink, Johannes M}, publisher = {Zenodo}, title = {{Surpassing the resistance quantum with a geometric superinductor}}, doi = {10.5281/ZENODO.4052882}, year = {2020}, } @misc{13071, abstract = {This dataset comprises all data shown in the plots of the main part of the submitted article "Bidirectional Electro-Optic Wavelength Conversion in the Quantum Ground State". Additional raw data are available from the corresponding author on reasonable request.}, author = {Hease, William J and Rueda Sanchez, Alfredo R and Sahu, Rishabh and Wulf, Matthias and Arnold, Georg M and Schwefel, Harald and Fink, Johannes M}, publisher = {Zenodo}, title = {{Bidirectional electro-optic wavelength conversion in the quantum ground state}}, doi = {10.5281/ZENODO.4266025}, year = {2020}, } @misc{13073, abstract = {The Mytilus complex of marine mussel species forms a mosaic of hybrid zones, found across temperate regions of the globe. This allows us to study "replicated" instances of secondary contact between closely-related species. Previous work on this complex has shown that local introgression is both widespread and highly heterogeneous, and has identified SNPs that are outliers of differentiation between lineages. Here, we developed an ancestry-informative panel of such SNPs. We then compared their frequencies in newly-sampled populations, including samples from within the hybrid zones, and parental populations at different distances from the contact. Results show that close to the hybrid zones, some outlier loci are near to fixation for the heterospecific allele, suggesting enhanced local introgression, or the local sweep of a shared ancestral allele. Conversely, genomic cline analyses, treating local parental populations as the reference, reveal a globally high concordance among loci, albeit with a few signals of asymmetric introgression. Enhanced local introgression at specific loci is consistent with the early transfer of adaptive variants after contact, possibly including asymmetric bi-stable variants (Dobzhansky-Muller incompatibilities), or haplotypes loaded with fewer deleterious mutations. Having escaped one barrier, however, these variants can be trapped or delayed at the next barrier, confining the introgression locally. These results shed light on the decay of species barriers during phases of contact.}, author = {Simon, Alexis and Fraisse, Christelle and El Ayari, Tahani and Liautard-Haag, Cathy and Strelkov, Petr and Welch, John and Bierne, Nicolas}, publisher = {Dryad}, title = {{How do species barriers decay? concordance and local introgression in mosaic hybrid zones of mussels}}, doi = {10.5061/DRYAD.R4XGXD29N}, year = {2020}, } @article{13341, abstract = {Scanning nanoscale superconducting quantum interference devices (nanoSQUIDs) are of growing interest for highly sensitive quantitative imaging of magnetic, spintronic, and transport properties of low-dimensional systems. Utilizing specifically designed grooved quartz capillaries pulled into a sharp pipette, we have fabricated the smallest SQUID-on-tip (SOT) devices with effective diameters down to 39 nm. Integration of a resistive shunt in close proximity to the pipette apex combined with self-aligned deposition of In and Sn, have resulted in SOT with a flux noise of 42 n$\Phi_0$Hz$^{-1/2}$, yielding a record low spin noise of 0.29 $\mu_B$Hz$^{-1/2}$. In addition, the new SOTs function at sub-Kelvin temperatures and in high magnetic fields of over 2.5 T. Integrating the SOTs into a scanning probe microscope allowed us to image the stray field of a single Fe$_3$O$_4$ nanocube at 300 mK. Our results show that the easy magnetization axis direction undergoes a transition from the (111) direction at room temperature to an in-plane orientation, which could be attributed to the Verwey phase transition in Fe$_3$O$_4$.}, author = {Anahory, Y. and Naren, H. R. and Lachman, E. O. and Sinai, S. Buhbut and Uri, A. and Embon, L. and Yaakobi, E. and Myasoedov, Y. and Huber, M. E. and Klajn, Rafal and Zeldov, E.}, issn = {2040-3372}, journal = {Nanoscale}, number = {5}, pages = {3174--3182}, publisher = {Royal Society of Chemistry}, title = {{SQUID-on-tip with single-electron spin sensitivity for high-field and ultra-low temperature nanomagnetic imaging}}, doi = {10.1039/C9NR08578E}, volume = {12}, year = {2020}, } @article{8199, abstract = {We investigate a mechanism to transiently stabilize topological phenomena in long-lived quasi-steady states of isolated quantum many-body systems driven at low frequencies. We obtain an analytical bound for the lifetime of the quasi-steady states which is exponentially large in the inverse driving frequency. Within this lifetime, the quasi-steady state is characterized by maximum entropy subject to the constraint of fixed number of particles in the system's Floquet-Bloch bands. In such a state, all the non-universal properties of these bands are washed out, hence only the topological properties persist.}, author = {Gulden, Tobias and Berg, Erez and Rudner, Mark Spencer and Lindner, Netanel}, issn = {2542-4653}, journal = {SciPost Physics}, publisher = {SciPost Foundation}, title = {{Exponentially long lifetime of universal quasi-steady states in topological Floquet pumps}}, doi = {10.21468/scipostphys.9.1.015}, volume = {9}, year = {2020}, } @article{8203, abstract = {Using inelastic cotunneling spectroscopy we observe a zero field splitting within the spin triplet manifold of Ge hut wire quantum dots. The states with spin ±1 in the confinement direction are energetically favored by up to 55 μeV compared to the spin 0 triplet state because of the strong spin–orbit coupling. The reported effect should be observable in a broad class of strongly confined hole quantum-dot systems and might need to be considered when operating hole spin qubits.}, author = {Katsaros, Georgios and Kukucka, Josip and Vukušić, Lada and Watzinger, Hannes and Gao, Fei and Wang, Ting and Zhang, Jian-Jun and Held, Karsten}, issn = {1530-6992}, journal = {Nano Letters}, number = {7}, pages = {5201--5206}, publisher = {American Chemical Society}, title = {{Zero field splitting of heavy-hole states in quantum dots}}, doi = {10.1021/acs.nanolett.0c01466}, volume = {20}, year = {2020}, } @article{8220, abstract = {Understanding to what extent stem cell potential is a cell-intrinsic property or an emergent behavior coming from global tissue dynamics and geometry is a key outstanding question of systems and stem cell biology. Here, we propose a theory of stem cell dynamics as a stochastic competition for access to a spatially localized niche, giving rise to a stochastic conveyor-belt model. Cell divisions produce a steady cellular stream which advects cells away from the niche, while random rearrangements enable cells away from the niche to be favorably repositioned. Importantly, even when assuming that all cells in a tissue are molecularly equivalent, we predict a common (“universal”) functional dependence of the long-term clonal survival probability on distance from the niche, as well as the emergence of a well-defined number of functional stem cells, dependent only on the rate of random movements vs. mitosis-driven advection. We test the predictions of this theory on datasets of pubertal mammary gland tips and embryonic kidney tips, as well as homeostatic intestinal crypts. Importantly, we find good agreement for the predicted functional dependency of the competition as a function of position, and thus functional stem cell number in each organ. This argues for a key role of positional fluctuations in dictating stem cell number and dynamics, and we discuss the applicability of this theory to other settings.}, author = {Corominas-Murtra, Bernat and Scheele, Colinda L.G.J. and Kishi, Kasumi and Ellenbroek, Saskia I.J. and Simons, Benjamin D. and Van Rheenen, Jacco and Hannezo, Edouard B}, issn = {10916490}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, number = {29}, pages = {16969--16975}, publisher = {National Academy of Sciences}, title = {{Stem cell lineage survival as a noisy competition for niche access}}, doi = {10.1073/pnas.1921205117}, volume = {117}, year = {2020}, } @article{8225, abstract = {Birch pollen allergy is among the most prevalent pollen allergies in Northern and Central Europe. This IgE-mediated disease can be treated with allergen immunotherapy (AIT), which typically gives rise to IgG antibodies inducing tolerance. Although the main mechanisms of allergen immunotherapy (AIT) are known, questions regarding possible Fc-mediated effects of IgG antibodies remain unanswered. This can mainly be attributed to the unavailability of appropriate tools, i.e., well-characterised recombinant antibodies (rAbs). We hereby aimed at providing human rAbs of several classes for mechanistic studies and as possible candidates for passive immunotherapy. We engineered IgE, IgG1, and IgG4 sharing the same variable region against the major birch pollen allergen Bet v 1 using Polymerase Incomplete Primer Extension (PIPE) cloning. We tested IgE functionality and IgG blocking capabilities using appropriate model cell lines. In vitro studies showed IgE engagement with FcεRI and CD23 and Bet v 1-dependent degranulation. Overall, we hereby present fully functional, human IgE, IgG1, and IgG4 sharing the same variable region against Bet v 1 and showcase possible applications in first mechanistic studies. Furthermore, our IgG antibodies might be useful candidates for passive immunotherapy of birch pollen allergy.}, author = {Köhler, Verena K. and Crescioli, Silvia and Fazekas-Singer, Judit and Bax, Heather J. and Hofer, Gerhard and Pranger, Christina L. and Hufnagl, Karin and Bianchini, Rodolfo and Flicker, Sabine and Keller, Walter and Karagiannis, Sophia N. and Jensen-Jarolim, Erika}, issn = {1422-0067}, journal = {International Journal of Molecular Sciences}, number = {16}, publisher = {MDPI}, title = {{Filling the antibody pipeline in allergy: PIPE cloning of IgE, IgG1 and IgG4 against the major birch pollen allergen Bet v 1}}, doi = {10.3390/ijms21165693}, volume = {21}, year = {2020}, } @article{8226, author = {Gotovina, Jelena and Bianchini, Rodolfo and Fazekas-Singer, Judit and Herrmann, Ina and Pellizzari, Giulia and Haidl, Ian D. and Hufnagl, Karin and Karagiannis, Sophia N. and Marshall, Jean S. and Jensen‐Jarolim, Erika}, issn = {0105-4538}, journal = {Allergy}, publisher = {Wiley}, title = {{Epinephrine drives human M2a allergic macrophages to a regulatory phenotype reducing mast cell degranulation in vitro}}, doi = {10.1111/all.14299}, year = {2020}, } @article{8250, abstract = {Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by “translation bottlenecks”: points in the translation cycle where antibiotics block ribosomal progression. To elucidate the underlying mechanisms of drug interactions between translation inhibitors, we generate translation bottlenecks genetically using inducible control of translation factors that regulate well-defined translation cycle steps. These perturbations accurately mimic antibiotic action and drug interactions, supporting that the interplay of different translation bottlenecks causes these interactions. We further show that growth laws, combined with drug uptake and binding kinetics, enable the direct prediction of a large fraction of observed interactions, yet fail to predict suppression. However, varying two translation bottlenecks simultaneously supports that dense traffic of ribosomes and competition for translation factors account for the previously unexplained suppression. These results highlight the importance of “continuous epistasis” in bacterial physiology.}, author = {Kavcic, Bor and Tkačik, Gašper and Bollenbach, Tobias}, issn = {2041-1723}, journal = {Nature Communications}, publisher = {Springer Nature}, title = {{Mechanisms of drug interactions between translation-inhibiting antibiotics}}, doi = {10.1038/s41467-020-17734-z}, volume = {11}, year = {2020}, } @misc{8254, abstract = {Here are the research data underlying the publication "Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus)". Further information are summed up in the README document. The files for this record have been updated and are now found in the linked DOI https://doi.org/10.15479/AT:ISTA:9192.}, author = {Arathoon, Louise S}, publisher = {Institute of Science and Technology Austria}, title = {{Estimating inbreeding and its effects in a long-term study of snapdragons (Antirrhinum majus)}}, doi = {10.15479/AT:ISTA:8254}, year = {2020}, }