---
_id: '7128'
abstract:
- lang: eng
  text: Loss of functional cardiomyocytes is a major determinant of heart failure
    after myocardial infarction. Previous high throughput screening studies have identified
    a few microRNAs (miRNAs) that can induce cardiomyocyte proliferation and stimulate
    cardiac regeneration in mice. Here, we show that all of the most effective of
    these miRNAs activate nuclear localization of the master transcriptional cofactor
    Yes-associated protein (YAP) and induce expression of YAP-responsive genes. In
    particular, miR-199a-3p directly targets two mRNAs coding for proteins impinging
    on the Hippo pathway, the upstream YAP inhibitory kinase TAOK1, and the E3 ubiquitin
    ligase β-TrCP, which leads to YAP degradation. Several of the pro-proliferative
    miRNAs (including miR-199a-3p) also inhibit filamentous actin depolymerization
    by targeting Cofilin2, a process that by itself activates YAP nuclear translocation.
    Thus, activation of YAP and modulation of the actin cytoskeleton are major components
    of the pro-proliferative action of miR-199a-3p and other miRNAs that induce cardiomyocyte
    proliferation.
article_processing_charge: Yes
article_type: original
author:
- first_name: Consuelo
  full_name: Torrini, Consuelo
  last_name: Torrini
- first_name: Ryan J
  full_name: Cubero, Ryan J
  id: 850B2E12-9CD4-11E9-837F-E719E6697425
  last_name: Cubero
  orcid: 0000-0003-0002-1867
- first_name: Ellen
  full_name: Dirkx, Ellen
  last_name: Dirkx
- first_name: Luca
  full_name: Braga, Luca
  last_name: Braga
- first_name: Hashim
  full_name: Ali, Hashim
  last_name: Ali
- first_name: Giulia
  full_name: Prosdocimo, Giulia
  last_name: Prosdocimo
- first_name: Maria Ines
  full_name: Gutierrez, Maria Ines
  last_name: Gutierrez
- first_name: Chiara
  full_name: Collesi, Chiara
  last_name: Collesi
- first_name: Danilo
  full_name: Licastro, Danilo
  last_name: Licastro
- first_name: Lorena
  full_name: Zentilin, Lorena
  last_name: Zentilin
- first_name: Miguel
  full_name: Mano, Miguel
  last_name: Mano
- first_name: Serena
  full_name: Zacchigna, Serena
  last_name: Zacchigna
- first_name: Michele
  full_name: Vendruscolo, Michele
  last_name: Vendruscolo
- first_name: Matteo
  full_name: Marsili, Matteo
  last_name: Marsili
- first_name: Areejit
  full_name: Samal, Areejit
  last_name: Samal
- first_name: Mauro
  full_name: Giacca, Mauro
  last_name: Giacca
citation:
  ama: Torrini C, Cubero RJ, Dirkx E, et al. Common regulatory pathways mediate activity
    of microRNAs inducing cardiomyocyte proliferation. <i>Cell Reports</i>. 2019;27(9):2759-2771.e5.
    doi:<a href="https://doi.org/10.1016/j.celrep.2019.05.005">10.1016/j.celrep.2019.05.005</a>
  apa: Torrini, C., Cubero, R. J., Dirkx, E., Braga, L., Ali, H., Prosdocimo, G.,
    … Giacca, M. (2019). Common regulatory pathways mediate activity of microRNAs
    inducing cardiomyocyte proliferation. <i>Cell Reports</i>. Elsevier. <a href="https://doi.org/10.1016/j.celrep.2019.05.005">https://doi.org/10.1016/j.celrep.2019.05.005</a>
  chicago: Torrini, Consuelo, Ryan J Cubero, Ellen Dirkx, Luca Braga, Hashim Ali,
    Giulia Prosdocimo, Maria Ines Gutierrez, et al. “Common Regulatory Pathways Mediate
    Activity of MicroRNAs Inducing Cardiomyocyte Proliferation.” <i>Cell Reports</i>.
    Elsevier, 2019. <a href="https://doi.org/10.1016/j.celrep.2019.05.005">https://doi.org/10.1016/j.celrep.2019.05.005</a>.
  ieee: C. Torrini <i>et al.</i>, “Common regulatory pathways mediate activity of
    microRNAs inducing cardiomyocyte proliferation,” <i>Cell Reports</i>, vol. 27,
    no. 9. Elsevier, p. 2759–2771.e5, 2019.
  ista: Torrini C, Cubero RJ, Dirkx E, Braga L, Ali H, Prosdocimo G, Gutierrez MI,
    Collesi C, Licastro D, Zentilin L, Mano M, Zacchigna S, Vendruscolo M, Marsili
    M, Samal A, Giacca M. 2019. Common regulatory pathways mediate activity of microRNAs
    inducing cardiomyocyte proliferation. Cell Reports. 27(9), 2759–2771.e5.
  mla: Torrini, Consuelo, et al. “Common Regulatory Pathways Mediate Activity of MicroRNAs
    Inducing Cardiomyocyte Proliferation.” <i>Cell Reports</i>, vol. 27, no. 9, Elsevier,
    2019, p. 2759–2771.e5, doi:<a href="https://doi.org/10.1016/j.celrep.2019.05.005">10.1016/j.celrep.2019.05.005</a>.
  short: C. Torrini, R.J. Cubero, E. Dirkx, L. Braga, H. Ali, G. Prosdocimo, M.I.
    Gutierrez, C. Collesi, D. Licastro, L. Zentilin, M. Mano, S. Zacchigna, M. Vendruscolo,
    M. Marsili, A. Samal, M. Giacca, Cell Reports 27 (2019) 2759–2771.e5.
date_created: 2019-11-26T22:30:07Z
date_published: 2019-05-28T00:00:00Z
date_updated: 2021-01-12T08:11:56Z
day: '28'
ddc:
- '576'
doi: 10.1016/j.celrep.2019.05.005
extern: '1'
external_id:
  pmid:
  - '31141697'
file:
- access_level: open_access
  checksum: c5d855d07263bfec718673385d0ea2d7
  content_type: application/pdf
  creator: rcubero
  date_created: 2019-11-26T22:30:43Z
  date_updated: 2020-07-14T12:47:50Z
  file_id: '7129'
  file_name: torrini_cellreports_2019.pdf
  file_size: 4650750
  relation: main_file
file_date_updated: 2020-07-14T12:47:50Z
has_accepted_license: '1'
intvolume: '        27'
issue: '9'
keyword:
- cardiomyocyte
- cell cycle
- Cofilin2
- cytoskeleton
- Hippo
- microRNA
- regeneration
- YAP
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 2759-2771.e5
pmid: 1
publication: Cell Reports
publication_identifier:
  issn:
  - 2211-1247
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte
  proliferation
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2019'
...