---
_id: '8653'
abstract:
- lang: eng
  text: "Mutations are the raw material of evolution and come in many different flavors.
    Point mutations change a single letter in the DNA sequence, while copy number
    mutations like duplications or deletions add or remove many letters of the DNA
    sequence simultaneously.  Each type of mutation exhibits specific properties like
    its rate of formation and reversal. \r\nGene expression is a fundamental phenotype
    that can be altered by both, point and copy number mutations. The following thesis
    is concerned with the dynamics of gene expression evolution and how it is affected
    by the properties exhibited by point and copy number mutations. Specifically,
    we are considering i) copy number mutations during adaptation to fluctuating environments
    and ii) the interaction of copy number and point mutations during adaptation to
    constant environments.  "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Isabella
  full_name: Tomanek, Isabella
  id: 3981F020-F248-11E8-B48F-1D18A9856A87
  last_name: Tomanek
  orcid: 0000-0001-6197-363X
citation:
  ama: Tomanek I. The evolution of gene expression by copy number and point mutations.
    2020. doi:<a href="https://doi.org/10.15479/AT:ISTA:8653">10.15479/AT:ISTA:8653</a>
  apa: Tomanek, I. (2020). <i>The evolution of gene expression by copy number and
    point mutations</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:8653">https://doi.org/10.15479/AT:ISTA:8653</a>
  chicago: Tomanek, Isabella. “The Evolution of Gene Expression by Copy Number and
    Point Mutations.” Institute of Science and Technology Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:8653">https://doi.org/10.15479/AT:ISTA:8653</a>.
  ieee: I. Tomanek, “The evolution of gene expression by copy number and point mutations,”
    Institute of Science and Technology Austria, 2020.
  ista: Tomanek I. 2020. The evolution of gene expression by copy number and point
    mutations. Institute of Science and Technology Austria.
  mla: Tomanek, Isabella. <i>The Evolution of Gene Expression by Copy Number and Point
    Mutations</i>. Institute of Science and Technology Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:8653">10.15479/AT:ISTA:8653</a>.
  short: I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations,
    Institute of Science and Technology Austria, 2020.
date_created: 2020-10-13T13:02:33Z
date_published: 2020-10-13T00:00:00Z
date_updated: 2023-09-07T13:22:42Z
day: '13'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:8653
file:
- access_level: closed
  checksum: c01d9f59794b4b70528f37637c17ad02
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: itomanek
  date_created: 2020-10-16T12:14:21Z
  date_updated: 2021-10-20T22:30:03Z
  embargo_to: open_access
  file_id: '8666'
  file_name: Thesis_ITomanek_final_201016.docx
  file_size: 25131884
  relation: source_file
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  content_type: application/pdf
  creator: itomanek
  date_created: 2020-10-16T12:14:21Z
  date_updated: 2021-10-20T22:30:03Z
  embargo: 2021-10-19
  file_id: '8667'
  file_name: Thesis_ITomanek_final_201016.pdf
  file_size: 15405675
  relation: main_file
file_date_updated: 2021-10-20T22:30:03Z
has_accepted_license: '1'
keyword:
- duplication
- amplification
- promoter
- CNV
- AMGET
- experimental evolution
- Escherichia coli
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '117'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '7652'
    relation: research_data
    status: public
status: public
supervisor:
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
title: The evolution of gene expression by copy number and point mutations
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...
---
_id: '5554'
abstract:
- lang: eng
  text: "The data stored here is used in Murat Tugrul's PhD thesis (Chapter 3), which
    is related to the evolution of bacterial RNA polymerase binding.\r\nMagdalena
    Steinrueck (PhD Student in Calin Guet's group at IST Austria) performed the experiments
    and created the data on de novo promoter evolution. Fabienne Jesse (PhD Student
    in Jon Bollback's group at IST Austria) performed the experiments and created
    the data on lac promoter evolution."
article_processing_charge: No
author:
- first_name: Murat
  full_name: Tugrul, Murat
  id: 37C323C6-F248-11E8-B48F-1D18A9856A87
  last_name: Tugrul
  orcid: 0000-0002-8523-0758
citation:
  ama: Tugrul M. Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase.
    2016. doi:<a href="https://doi.org/10.15479/AT:ISTA:43">10.15479/AT:ISTA:43</a>
  apa: Tugrul, M. (2016). Experimental Data for Binding Site Evolution of Bacterial
    RNA Polymerase. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:43">https://doi.org/10.15479/AT:ISTA:43</a>
  chicago: Tugrul, Murat. “Experimental Data for Binding Site Evolution of Bacterial
    RNA Polymerase.” Institute of Science and Technology Austria, 2016. <a href="https://doi.org/10.15479/AT:ISTA:43">https://doi.org/10.15479/AT:ISTA:43</a>.
  ieee: M. Tugrul, “Experimental Data for Binding Site Evolution of Bacterial RNA
    Polymerase.” Institute of Science and Technology Austria, 2016.
  ista: Tugrul M. 2016. Experimental Data for Binding Site Evolution of Bacterial
    RNA Polymerase, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT:ISTA:43">10.15479/AT:ISTA:43</a>.
  mla: Tugrul, Murat. <i>Experimental Data for Binding Site Evolution of Bacterial
    RNA Polymerase</i>. Institute of Science and Technology Austria, 2016, doi:<a
    href="https://doi.org/10.15479/AT:ISTA:43">10.15479/AT:ISTA:43</a>.
  short: M. Tugrul, (2016).
contributor:
- contributor_type: researcher
  first_name: Magdalena
  id: 2C023F40-F248-11E8-B48F-1D18A9856A87
  last_name: Steinrück
- contributor_type: researcher
  first_name: Fabienne
  id: 4C8C26A4-F248-11E8-B48F-1D18A9856A87
  last_name: Jesse
datarep_id: '43'
date_created: 2018-12-12T12:31:30Z
date_published: 2016-05-12T00:00:00Z
date_updated: 2024-02-21T13:50:34Z
day: '12'
department:
- _id: NiBa
- _id: JoBo
doi: 10.15479/AT:ISTA:43
file:
- access_level: open_access
  checksum: 1fc0a10bb7ce110fcb5e1fbe3cf0c4e2
  content_type: application/zip
  creator: system
  date_created: 2018-12-12T13:03:08Z
  date_updated: 2020-07-14T12:47:01Z
  file_id: '5626'
  file_name: IST-2016-43-v1+1_DATA_MTugrul_PhDThesis_Chapter3.zip
  file_size: 1123495
  relation: main_file
file_date_updated: 2020-07-14T12:47:01Z
has_accepted_license: '1'
keyword:
- RNAP binding
- de novo promoter evolution
- lac promoter
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '05'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '1131'
    relation: used_in_publication
    status: public
status: public
title: Experimental Data for Binding Site Evolution of Bacterial RNA Polymerase
tmp:
  image: /images/cc_0.png
  legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
  name: Creative Commons Public Domain Dedication (CC0 1.0)
  short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2016'
...