@article{9999,
  abstract     = {The developmental strategies used by progenitor cells to endure a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here we uncovered a progenitor cell allocation mechanism that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra-embryonic tissues. Progenitors of the zebrafish laterality organ originate from the surface epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long-term apical contacts that enable the epithelial layer to pull a subset of progenitors along their way towards the vegetal pole. The remaining delaminated progenitors follow apically-attached progenitors’ movement by a co-attraction mechanism, avoiding sequestration by the adjacent endoderm, ensuring their fate and collective allocation at the differentiation site. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. Impact Statement: Incomplete delamination serves as a cellular platform for coordinated tissue movements during development, guiding newly formed progenitor cell groups to the differentiation site.},
  author       = {Pulgar, Eduardo and Schwayer, Cornelia and Guerrero, Néstor and López, Loreto and Márquez, Susana and Härtel, Steffen and Soto, Rodrigo and Heisenberg, Carl Philipp and Concha, Miguel L.},
  issn         = {2050-084X},
  journal      = {eLife},
  keywords     = {cell delamination, apical constriction, dragging, mechanical forces, collective 18 locomotion, dorsal forerunner cells, zebrafish},
  publisher    = {eLife Sciences Publications},
  title        = {{Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism}},
  doi          = {10.7554/eLife.66483},
  volume       = {10},
  year         = {2021},
}