[{"issue":"1","article_type":"original","intvolume":"        16","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"lang":"eng","text":"SnSe has emerged as one of the most promising materials for thermoelectric energy conversion due to its extraordinary performance in its single-crystal form and its low-cost constituent elements. However, to achieve an economic impact, the polycrystalline counterpart needs to replicate the performance of the single crystal. Herein, we optimize the thermoelectric performance of polycrystalline SnSe produced by consolidating solution-processed and surface-engineered SnSe particles. In particular, the SnSe particles are coated with CdSe molecular complexes that crystallize during the sintering process, forming CdSe nanoparticles. The presence of CdSe nanoparticles inhibits SnSe grain growth during the consolidation step due to Zener pinning, yielding a material with a high density of grain boundaries. Moreover, the resulting SnSe–CdSe nanocomposites present a large number of defects at different length scales, which significantly reduce the thermal conductivity. The produced SnSe–CdSe nanocomposites exhibit thermoelectric figures of merit up to 2.2 at 786 K, which is among the highest reported for solution-processed SnSe."}],"volume":16,"scopus_import":"1","title":"Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance","date_created":"2021-09-24T07:55:12Z","language":[{"iso":"eng"}],"department":[{"_id":"MaIb"}],"type":"journal_article","day":"25","citation":{"mla":"Liu, Yu, et al. “Defect Engineering in Solution-Processed Polycrystalline SnSe Leads to High Thermoelectric Performance.” <i>ACS Nano</i>, vol. 16, no. 1, American Chemical Society , 2022, pp. 78–88, doi:<a href=\"https://doi.org/10.1021/acsnano.1c06720\">10.1021/acsnano.1c06720</a>.","chicago":"Liu, Yu, Mariano Calcabrini, Yuan Yu, Seungho Lee, Cheng Chang, Jérémy David, Tanmoy Ghosh, et al. “Defect Engineering in Solution-Processed Polycrystalline SnSe Leads to High Thermoelectric Performance.” <i>ACS Nano</i>. American Chemical Society , 2022. <a href=\"https://doi.org/10.1021/acsnano.1c06720\">https://doi.org/10.1021/acsnano.1c06720</a>.","ista":"Liu Y, Calcabrini M, Yu Y, Lee S, Chang C, David J, Ghosh T, Spadaro MC, Xie C, Cojocaru-Mirédin O, Arbiol J, Ibáñez M. 2022. Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance. ACS Nano. 16(1), 78–88.","apa":"Liu, Y., Calcabrini, M., Yu, Y., Lee, S., Chang, C., David, J., … Ibáñez, M. (2022). Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance. <i>ACS Nano</i>. American Chemical Society . <a href=\"https://doi.org/10.1021/acsnano.1c06720\">https://doi.org/10.1021/acsnano.1c06720</a>","ieee":"Y. Liu <i>et al.</i>, “Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance,” <i>ACS Nano</i>, vol. 16, no. 1. American Chemical Society , pp. 78–88, 2022.","short":"Y. Liu, M. Calcabrini, Y. Yu, S. Lee, C. Chang, J. David, T. Ghosh, M.C. Spadaro, C. Xie, O. Cojocaru-Mirédin, J. Arbiol, M. Ibáñez, ACS Nano 16 (2022) 78–88.","ama":"Liu Y, Calcabrini M, Yu Y, et al. Defect engineering in solution-processed polycrystalline SnSe leads to high thermoelectric performance. <i>ACS Nano</i>. 2022;16(1):78-88. doi:<a href=\"https://doi.org/10.1021/acsnano.1c06720\">10.1021/acsnano.1c06720</a>"},"related_material":{"record":[{"relation":"dissertation_contains","id":"12885","status":"public"}]},"doi":"10.1021/acsnano.1c06720","quality_controlled":"1","oa_version":"Published Version","isi":1,"oa":1,"author":[{"orcid":"0000-0001-7313-6740","full_name":"Liu, Yu","first_name":"Yu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87","last_name":"Liu"},{"first_name":"Mariano","full_name":"Calcabrini, Mariano","id":"45D7531A-F248-11E8-B48F-1D18A9856A87","last_name":"Calcabrini"},{"last_name":"Yu","first_name":"Yuan","full_name":"Yu, Yuan"},{"last_name":"Lee","id":"BB243B88-D767-11E9-B658-BC13E6697425","orcid":"0000-0002-6962-8598","full_name":"Lee, Seungho","first_name":"Seungho"},{"last_name":"Chang","id":"9E331C2E-9F27-11E9-AE48-5033E6697425","first_name":"Cheng","full_name":"Chang, Cheng","orcid":"0000-0002-9515-4277"},{"first_name":"Jérémy","full_name":"David, Jérémy","last_name":"David"},{"last_name":"Ghosh","id":"a5fc9bc3-feff-11ea-93fe-e8015a3c7e9d","full_name":"Ghosh, Tanmoy","first_name":"Tanmoy"},{"first_name":"Maria Chiara","full_name":"Spadaro, Maria Chiara","last_name":"Spadaro"},{"full_name":"Xie, Chenyang","first_name":"Chenyang","last_name":"Xie"},{"full_name":"Cojocaru-Mirédin, Oana","first_name":"Oana","last_name":"Cojocaru-Mirédin"},{"last_name":"Arbiol","first_name":"Jordi","full_name":"Arbiol, Jordi"},{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","last_name":"Ibáñez","full_name":"Ibáñez, Maria","first_name":"Maria","orcid":"0000-0001-5013-2843"}],"keyword":["tin selenide","nanocomposite","grain growth","Zener pinning","thermoelectricity","annealing","solution processing"],"external_id":{"isi":["000767223400008"],"pmid":["34549956"]},"acknowledgement":"This work was financially supported by IST Austria and the Werner Siemens Foundation. Y.L. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement No. 754411. S.L. and M.C. received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant Agreement No. 665385. J.D. acknowledges funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 665919 (P-SPHERE) cofunded by Severo Ochoa Programme. C.C. acknowledges funding from the FWF “Lise Meitner Fellowship” grant agreement M 2889-N. Y.Y. and O.C.-M. acknowledge the financial support from DFG within the project SFB 917: Nanoswitches. M.C.S. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 754510 (PROBIST) and the Severo Ochoa programme. J.D. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No. 665919 (P-SPHERE) cofunded by Severo Ochoa Programme. The ICN2 is funded by the CERCA Program/Generalitat de Catalunya and by the Severo Ochoa program of the Spanish Ministry of Economy, Industry, and Competitiveness (MINECO, grant no. SEV-2017-0706). ICN2 acknowledges funding from Generalitat de Catalunya 2017 SGR 327 and the Spanish MINECO project NANOGEN (PID2020-116093RB-C43). This project received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 823717-ESTEEM3. The FIB sample preparation was conducted in the LMA-INA-Universidad de Zaragoza.","year":"2022","publication_identifier":{"eissn":["1936-086X"],"issn":["1936-0851"]},"date_published":"2022-01-25T00:00:00Z","status":"public","ddc":["540"],"page":"78-88","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"Yes (via OA deal)","ec_funded":1,"publication_status":"published","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"},{"call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program"},{"_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A","name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery"},{"name":"Bottom-up Engineering for Thermoelectric Applications","grant_number":"M02889","_id":"9B8804FC-BA93-11EA-9121-9846C619BF3A"}],"date_updated":"2023-08-02T14:41:05Z","_id":"10042","publisher":"American Chemical Society ","has_accepted_license":"1","file_date_updated":"2022-03-02T16:17:29Z","pmid":1,"publication":"ACS Nano","file":[{"date_updated":"2022-03-02T16:17:29Z","creator":"cchlebak","access_level":"open_access","file_id":"10808","file_name":"2022_ACSNano_Liu.pdf","date_created":"2022-03-02T16:17:29Z","checksum":"74f9c1aa5f95c0b992a4328e8e0247b4","file_size":9050764,"success":1,"relation":"main_file","content_type":"application/pdf"}],"month":"01"},{"volume":22,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"lang":"eng","text":"Size control is a fundamental question in biology, showing incremental complexity in plants, whose cells possess a rigid cell wall. The phytohormone auxin is a vital growth regulator with central importance for differential growth control. Our results indicate that auxin-reliant growth programs affect the molecular complexity of xyloglucans, the major type of cell wall hemicellulose in eudicots. Auxin-dependent induction and repression of growth coincide with reduced and enhanced molecular complexity of xyloglucans, respectively. In agreement with a proposed function in growth control, genetic interference with xyloglucan side decorations distinctly modulates auxin-dependent differential growth rates. Our work proposes that auxin-dependent growth programs have a spatially defined effect on xyloglucan’s molecular structure, which in turn affects cell wall mechanics and specifies differential, gravitropic hypocotyl growth."}],"article_type":"original","issue":"17","article_number":"9222","intvolume":"        22","department":[{"_id":"EvBe"}],"date_created":"2021-09-05T22:01:24Z","language":[{"iso":"eng"}],"scopus_import":"1","title":"Xyloglucan remodeling defines auxin-dependent differential tissue expansion in plants","citation":{"chicago":"Velasquez, Silvia Melina, Xiaoyuan Guo, Marçal Gallemi, Bibek Aryal, Peter Venhuizen, Elke Barbez, Kai Alexander Dünser, et al. “Xyloglucan Remodeling Defines Auxin-Dependent Differential Tissue Expansion in Plants.” <i>International Journal of Molecular Sciences</i>. MDPI, 2021. <a href=\"https://doi.org/10.3390/ijms22179222\">https://doi.org/10.3390/ijms22179222</a>.","ista":"Velasquez SM, Guo X, Gallemi M, Aryal B, Venhuizen P, Barbez E, Dünser KA, Darino M, Pӗnčík A, Novák O, Kalyna M, Mouille G, Benková E, Bhalerao RP, Mravec J, Kleine-Vehn J. 2021. Xyloglucan remodeling defines auxin-dependent differential tissue expansion in plants. International Journal of Molecular Sciences. 22(17), 9222.","apa":"Velasquez, S. M., Guo, X., Gallemi, M., Aryal, B., Venhuizen, P., Barbez, E., … Kleine-Vehn, J. (2021). Xyloglucan remodeling defines auxin-dependent differential tissue expansion in plants. <i>International Journal of Molecular Sciences</i>. MDPI. <a href=\"https://doi.org/10.3390/ijms22179222\">https://doi.org/10.3390/ijms22179222</a>","ama":"Velasquez SM, Guo X, Gallemi M, et al. Xyloglucan remodeling defines auxin-dependent differential tissue expansion in plants. <i>International Journal of Molecular Sciences</i>. 2021;22(17). doi:<a href=\"https://doi.org/10.3390/ijms22179222\">10.3390/ijms22179222</a>","short":"S.M. Velasquez, X. Guo, M. Gallemi, B. Aryal, P. Venhuizen, E. Barbez, K.A. Dünser, M. Darino, A. Pӗnčík, O. Novák, M. Kalyna, G. Mouille, E. Benková, R.P. Bhalerao, J. Mravec, J. Kleine-Vehn, International Journal of Molecular Sciences 22 (2021).","ieee":"S. M. Velasquez <i>et al.</i>, “Xyloglucan remodeling defines auxin-dependent differential tissue expansion in plants,” <i>International Journal of Molecular Sciences</i>, vol. 22, no. 17. MDPI, 2021.","mla":"Velasquez, Silvia Melina, et al. “Xyloglucan Remodeling Defines Auxin-Dependent Differential Tissue Expansion in Plants.” <i>International Journal of Molecular Sciences</i>, vol. 22, no. 17, 9222, MDPI, 2021, doi:<a href=\"https://doi.org/10.3390/ijms22179222\">10.3390/ijms22179222</a>."},"type":"journal_article","day":"26","oa_version":"Published Version","quality_controlled":"1","doi":"10.3390/ijms22179222","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"Yes","publication_identifier":{"eissn":["1422-0067"],"issn":["1661-6596"]},"year":"2021","date_published":"2021-08-26T00:00:00Z","ddc":["575"],"status":"public","acknowledgement":"We are grateful to Paul Knox, Markus Pauly, Malcom O’Neill, and Ignacio Zarra for providing published material; the BOKU-VIBT Imaging Center for access and M. Debreczeny for expertise; J.I. Thaker and Georg Seifert for critical reading.\r\n","external_id":{"isi":["000694347100001"],"pmid":["34502129"]},"author":[{"first_name":"Silvia Melina","full_name":"Velasquez, Silvia Melina","last_name":"Velasquez"},{"last_name":"Guo","full_name":"Guo, Xiaoyuan","first_name":"Xiaoyuan"},{"last_name":"Gallemi","id":"460C6802-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4675-6893","full_name":"Gallemi, Marçal","first_name":"Marçal"},{"first_name":"Bibek","full_name":"Aryal, Bibek","last_name":"Aryal"},{"last_name":"Venhuizen","first_name":"Peter","full_name":"Venhuizen, Peter"},{"last_name":"Barbez","first_name":"Elke","full_name":"Barbez, Elke"},{"last_name":"Dünser","full_name":"Dünser, Kai Alexander","first_name":"Kai Alexander"},{"full_name":"Darino, Martin","first_name":"Martin","last_name":"Darino"},{"first_name":"Aleš","full_name":"Pӗnčík, Aleš","last_name":"Pӗnčík"},{"full_name":"Novák, Ondřej","first_name":"Ondřej","last_name":"Novák"},{"last_name":"Kalyna","full_name":"Kalyna, Maria","first_name":"Maria"},{"first_name":"Gregory","full_name":"Mouille, Gregory","last_name":"Mouille"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","last_name":"Benková","first_name":"Eva","full_name":"Benková, Eva","orcid":"0000-0002-8510-9739"},{"full_name":"Bhalerao, Rishikesh P.","first_name":"Rishikesh P.","last_name":"Bhalerao"},{"last_name":"Mravec","first_name":"Jozef","full_name":"Mravec, Jozef"},{"full_name":"Kleine-Vehn, Jürgen","first_name":"Jürgen","last_name":"Kleine-Vehn"}],"keyword":["auxin","growth","cell wall","xyloglucans","hypocotyls","gravitropism"],"oa":1,"isi":1,"_id":"9986","date_updated":"2023-10-31T19:29:38Z","publication_status":"published","file_date_updated":"2021-09-07T09:04:53Z","has_accepted_license":"1","publisher":"MDPI","month":"08","file":[{"checksum":"6b7055cf89f1b7ed8594c3fdf56f000b","file_size":2162247,"content_type":"application/pdf","relation":"main_file","creator":"cchlebak","date_updated":"2021-09-07T09:04:53Z","access_level":"open_access","file_id":"9988","date_created":"2021-09-06T12:50:19Z","file_name":"2021_IntJMolecularSciences_Velasquez.pdf"}],"publication":"International Journal of Molecular Sciences","pmid":1},{"doi":"10.15479/AT:ISTA:8097","oa_version":"Published Version","file":[{"file_name":"natComm_2020_scripts.zip","date_created":"2020-07-06T20:38:27Z","file_id":"8098","date_updated":"2020-07-14T12:48:09Z","creator":"bkavcic","access_level":"open_access","content_type":"application/zip","relation":"main_file","checksum":"5c321dbbb6d4b3c85da786fd3ebbdc98","file_size":255770756}],"month":"07","publisher":"Institute of Science and Technology Austria","has_accepted_license":"1","file_date_updated":"2020-07-14T12:48:09Z","day":"15","type":"research_data","citation":{"mla":"Kavcic, Bor. <i>Analysis Scripts and Research Data for the Paper “Mechanisms of Drug Interactions between Translation-Inhibiting Antibiotics.”</i> Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8097\">10.15479/AT:ISTA:8097</a>.","apa":"Kavcic, B. (2020). Analysis scripts and research data for the paper “Mechanisms of drug interactions between translation-inhibiting antibiotics.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8097\">https://doi.org/10.15479/AT:ISTA:8097</a>","ista":"Kavcic B. 2020. Analysis scripts and research data for the paper ‘Mechanisms of drug interactions between translation-inhibiting antibiotics’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:8097\">10.15479/AT:ISTA:8097</a>.","chicago":"Kavcic, Bor. “Analysis Scripts and Research Data for the Paper ‘Mechanisms of Drug Interactions between Translation-Inhibiting Antibiotics.’” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8097\">https://doi.org/10.15479/AT:ISTA:8097</a>.","ieee":"B. Kavcic, “Analysis scripts and research data for the paper ‘Mechanisms of drug interactions between translation-inhibiting antibiotics.’” Institute of Science and Technology Austria, 2020.","ama":"Kavcic B. Analysis scripts and research data for the paper “Mechanisms of drug interactions between translation-inhibiting antibiotics.” 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8097\">10.15479/AT:ISTA:8097</a>","short":"B. Kavcic, (2020)."},"title":"Analysis scripts and research data for the paper \"Mechanisms of drug interactions between translation-inhibiting antibiotics\"","contributor":[{"first_name":"Gašper","contributor_type":"research_group","orcid":"0000-0002-6699-1455","last_name":"Tkačik","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Bollenbach","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","first_name":"Tobias","contributor_type":"research_group"}],"date_updated":"2024-02-21T12:40:51Z","_id":"8097","date_created":"2020-07-06T20:40:19Z","department":[{"_id":"GaTk"}],"author":[{"orcid":"0000-0001-6041-254X","full_name":"Kavcic, Bor","first_name":"Bor","last_name":"Kavcic","id":"350F91D2-F248-11E8-B48F-1D18A9856A87"}],"oa":1,"keyword":["Escherichia coli","antibiotic combinations","translation","growth laws","drug interactions","bacterial physiology","translation inhibitors"],"date_published":"2020-07-15T00:00:00Z","status":"public","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"year":"2020","acknowledged_ssus":[{"_id":"LifeSc"}],"abstract":[{"text":"Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by \"translation bottlenecks\": points in the translation cycle where antibiotics block ribosomal progression. To elucidate the underlying mechanisms of drug interactions between translation inhibitors, we generate translation bottlenecks genetically using inducible control of translation factors that regulate well-defined translation cycle steps. These perturbations accurately mimic antibiotic action and drug interactions, supporting that the interplay of different translation bottlenecks causes these interactions. We further show that growth laws, combined with drug uptake and binding kinetics, enable the direct prediction of a large fraction of observed interactions, yet fail to predict suppression. However, varying two translation bottlenecks simultaneously supports that dense traffic of ribosomes and competition for translation factors account for the previously unexplained suppression. These results highlight the importance of \"continuous epistasis\" in bacterial physiology.","lang":"eng"}],"article_processing_charge":"No","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"doi":"10.15479/AT:ISTA:8930","file":[{"checksum":"60a818edeffaa7da1ebf5f8fbea9ba18","file_size":315494370,"success":1,"content_type":"application/zip","relation":"main_file","file_id":"8932","creator":"bkavcic","date_updated":"2020-12-09T15:00:19Z","access_level":"open_access","date_created":"2020-12-09T15:00:19Z","file_name":"PLoSCompBiol2020_datarep.zip"}],"oa_version":"Published Version","month":"12","has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","type":"research_data","day":"10","file_date_updated":"2020-12-09T15:00:19Z","citation":{"mla":"Kavcic, Bor. <i>Analysis Scripts and Research Data for the Paper “Minimal Biophysical Model of Combined Antibiotic Action.”</i> Institute of Science and Technology Austria, 2020, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8930\">10.15479/AT:ISTA:8930</a>.","short":"B. Kavcic, (2020).","ieee":"B. Kavcic, “Analysis scripts and research data for the paper ‘Minimal biophysical model of combined antibiotic action.’” Institute of Science and Technology Austria, 2020.","ama":"Kavcic B. Analysis scripts and research data for the paper “Minimal biophysical model of combined antibiotic action.” 2020. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:8930\">10.15479/AT:ISTA:8930</a>","ista":"Kavcic B. 2020. Analysis scripts and research data for the paper ‘Minimal biophysical model of combined antibiotic action’, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:8930\">10.15479/AT:ISTA:8930</a>.","apa":"Kavcic, B. (2020). Analysis scripts and research data for the paper “Minimal biophysical model of combined antibiotic action.” Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:8930\">https://doi.org/10.15479/AT:ISTA:8930</a>","chicago":"Kavcic, Bor. “Analysis Scripts and Research Data for the Paper ‘Minimal Biophysical Model of Combined Antibiotic Action.’” Institute of Science and Technology Austria, 2020. <a href=\"https://doi.org/10.15479/AT:ISTA:8930\">https://doi.org/10.15479/AT:ISTA:8930</a>."},"related_material":{"record":[{"id":"8997","status":"public","relation":"used_in_publication"}]},"contributor":[{"contributor_type":"supervisor","first_name":"Gašper","orcid":"0000-0002-6699-1455","last_name":"Tkačik","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87"},{"id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","last_name":"Bollenbach","contributor_type":"supervisor","first_name":"Tobias"}],"title":"Analysis scripts and research data for the paper \"Minimal biophysical model of combined antibiotic action\"","date_updated":"2024-02-21T12:41:42Z","date_created":"2020-12-09T15:04:02Z","_id":"8930","department":[{"_id":"GaTk"}],"keyword":["Escherichia coli","antibiotic combinations","translation","growth laws","drug interactions","bacterial physiology","translation inhibitors"],"oa":1,"author":[{"last_name":"Kavcic","id":"350F91D2-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6041-254X","first_name":"Bor","full_name":"Kavcic, Bor"}],"year":"2020","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"abstract":[{"text":"Phenomenological relations such as Ohm’s or Fourier’s law have a venerable history in physics but are still scarce in biology. This situation restrains predictive theory. Here, we build on bacterial “growth laws,” which capture physiological feedback between translation and cell growth, to construct a minimal biophysical model for the combined action of ribosome-targeting antibiotics. Our model predicts drug interactions like antagonism or synergy solely from responses to individual drugs. We provide analytical results for limiting cases, which agree well with numerical results. We systematically refine the model by including direct physical interactions of different antibiotics on the ribosome. In a limiting case, our model provides a mechanistic underpinning for recent predictions of higher-order interactions that were derived using entropy maximization. We further refine the model to include the effects of antibiotics that mimic starvation and the presence of resistance genes. We describe the impact of a starvation-mimicking antibiotic on drug interactions analytically and verify it experimentally. Our extended model suggests a change in the type of drug interaction that depends on the strength of resistance, which challenges established rescaling paradigms. We experimentally show that the presence of unregulated resistance genes can lead to altered drug interaction, which agrees with the prediction of the model. While minimal, the model is readily adaptable and opens the door to predicting interactions of second and higher-order in a broad range of biological systems.","lang":"eng"}],"ddc":["570"],"status":"public","date_published":"2020-12-10T00:00:00Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No"},{"_id":"6566","date_updated":"2023-08-28T12:20:53Z","project":[{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"ec_funded":1,"publication_status":"published","article_processing_charge":"Yes (in subscription journal)","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"6572-6580","date_published":"2019-06-25T00:00:00Z","status":"public","ddc":["540"],"year":"2019","publication_identifier":{"issn":["1936-0851"],"eissn":["1936-086X"]},"keyword":["colloidal nanoparticles","asymmetric nanoparticles","inorganic ligands","heterostructures","catalyst assisted growth","nanocomposites","thermoelectrics"],"isi":1,"oa":1,"external_id":{"pmid":["31185159"],"isi":["000473248300043"]},"author":[{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","last_name":"Ibáñez","full_name":"Ibáñez, Maria","first_name":"Maria","orcid":"0000-0001-5013-2843"},{"last_name":"Genç","first_name":"Aziz","full_name":"Genç, Aziz"},{"first_name":"Roger","full_name":"Hasler, Roger","last_name":"Hasler"},{"orcid":"0000-0001-7313-6740","first_name":"Yu","full_name":"Liu, Yu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87","last_name":"Liu"},{"last_name":"Dobrozhan","first_name":"Oleksandr","full_name":"Dobrozhan, Oleksandr"},{"full_name":"Nazarenko, Olga","first_name":"Olga","last_name":"Nazarenko"},{"last_name":"Mata","full_name":"Mata, María de la","first_name":"María de la"},{"first_name":"Jordi","full_name":"Arbiol, Jordi","last_name":"Arbiol"},{"first_name":"Andreu","full_name":"Cabot, Andreu","last_name":"Cabot"},{"first_name":"Maksym V.","full_name":"Kovalenko, Maksym V.","last_name":"Kovalenko"}],"month":"06","file":[{"date_created":"2019-07-16T14:17:09Z","file_name":"2019_ACSNano_Ibanez.pdf","date_updated":"2020-07-14T12:47:33Z","creator":"dernst","access_level":"open_access","file_id":"6644","relation":"main_file","content_type":"application/pdf","file_size":8628690}],"publication":"ACS Nano","pmid":1,"file_date_updated":"2020-07-14T12:47:33Z","has_accepted_license":"1","publisher":"American Chemical Society","department":[{"_id":"MaIb"}],"language":[{"iso":"eng"}],"date_created":"2019-06-18T13:54:34Z","title":"Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks","scopus_import":"1","volume":13,"abstract":[{"lang":"eng","text":"Methodologies that involve the use of nanoparticles as “artificial atoms” to rationally build materials in a bottom-up fashion are particularly well-suited to control the matter at the nanoscale. Colloidal synthetic routes allow for an exquisite control over such “artificial atoms” in terms of size, shape, and crystal phase as well as core and surface compositions. We present here a bottom-up approach to produce Pb–Ag–K–S–Te nanocomposites, which is a highly promising system for thermoelectric energy conversion. First, we developed a high-yield and scalable colloidal synthesis route to uniform lead sulfide (PbS) nanorods, whose tips are made of silver sulfide (Ag2S). We then took advantage of the large surface-to-volume ratio to introduce a p-type dopant (K) by replacing native organic ligands with K2Te. Upon thermal consolidation, K2Te-surface modified PbS–Ag2S nanorods yield p-type doped nanocomposites with PbTe and PbS as major phases and Ag2S and Ag2Te as embedded nanoinclusions. Thermoelectric characterization of such consolidated nanosolids showed a high thermoelectric figure-of-merit of 1 at 620 K."}],"intvolume":"        13","issue":"6","article_type":"original","oa_version":"Published Version","doi":"10.1021/acsnano.9b00346","quality_controlled":"1","citation":{"chicago":"Ibáñez, Maria, Aziz Genç, Roger Hasler, Yu Liu, Oleksandr Dobrozhan, Olga Nazarenko, María de la Mata, Jordi Arbiol, Andreu Cabot, and Maksym V. Kovalenko. “Tuning Transport Properties in Thermoelectric Nanocomposites through Inorganic Ligands and Heterostructured Building Blocks.” <i>ACS Nano</i>. American Chemical Society, 2019. <a href=\"https://doi.org/10.1021/acsnano.9b00346\">https://doi.org/10.1021/acsnano.9b00346</a>.","ista":"Ibáñez M, Genç A, Hasler R, Liu Y, Dobrozhan O, Nazarenko O, Mata M de la, Arbiol J, Cabot A, Kovalenko MV. 2019. Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. ACS Nano. 13(6), 6572–6580.","apa":"Ibáñez, M., Genç, A., Hasler, R., Liu, Y., Dobrozhan, O., Nazarenko, O., … Kovalenko, M. V. (2019). Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. <i>ACS Nano</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsnano.9b00346\">https://doi.org/10.1021/acsnano.9b00346</a>","ama":"Ibáñez M, Genç A, Hasler R, et al. Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. <i>ACS Nano</i>. 2019;13(6):6572-6580. doi:<a href=\"https://doi.org/10.1021/acsnano.9b00346\">10.1021/acsnano.9b00346</a>","ieee":"M. Ibáñez <i>et al.</i>, “Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks,” <i>ACS Nano</i>, vol. 13, no. 6. American Chemical Society, pp. 6572–6580, 2019.","short":"M. Ibáñez, A. Genç, R. Hasler, Y. Liu, O. Dobrozhan, O. Nazarenko, M. de la Mata, J. Arbiol, A. Cabot, M.V. Kovalenko, ACS Nano 13 (2019) 6572–6580.","mla":"Ibáñez, Maria, et al. “Tuning Transport Properties in Thermoelectric Nanocomposites through Inorganic Ligands and Heterostructured Building Blocks.” <i>ACS Nano</i>, vol. 13, no. 6, American Chemical Society, 2019, pp. 6572–80, doi:<a href=\"https://doi.org/10.1021/acsnano.9b00346\">10.1021/acsnano.9b00346</a>."},"type":"journal_article","day":"25"}]