[{"date_published":"2009-11-17T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["1534-5807"]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.1016/j.devcel.2009.10.007","open_access":"1"}],"status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","publication":"Developmental Cell","oa_version":"Published Version","month":"11","language":[{"iso":"eng"}],"keyword":["Developmental Biology","Cell Biology","General Biochemistry","Genetics and Molecular Biology","Molecular Biology"],"date_updated":"2022-07-18T08:55:01Z","citation":{"chicago":"Hetzer, Martin, and Susan R. Wente. “Border Control at the Nucleus: Biogenesis and Organization of the Nuclear Membrane and Pore Complexes.” <i>Developmental Cell</i>. Elsevier, 2009. <a href=\"https://doi.org/10.1016/j.devcel.2009.10.007\">https://doi.org/10.1016/j.devcel.2009.10.007</a>.","ieee":"M. Hetzer and S. R. Wente, “Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes,” <i>Developmental Cell</i>, vol. 17, no. 5. Elsevier, pp. 606–616, 2009.","apa":"Hetzer, M., &#38; Wente, S. R. (2009). Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2009.10.007\">https://doi.org/10.1016/j.devcel.2009.10.007</a>","ama":"Hetzer M, Wente SR. Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. <i>Developmental Cell</i>. 2009;17(5):606-616. doi:<a href=\"https://doi.org/10.1016/j.devcel.2009.10.007\">10.1016/j.devcel.2009.10.007</a>","ista":"Hetzer M, Wente SR. 2009. Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. Developmental Cell. 17(5), 606–616.","mla":"Hetzer, Martin, and Susan R. Wente. “Border Control at the Nucleus: Biogenesis and Organization of the Nuclear Membrane and Pore Complexes.” <i>Developmental Cell</i>, vol. 17, no. 5, Elsevier, 2009, pp. 606–16, doi:<a href=\"https://doi.org/10.1016/j.devcel.2009.10.007\">10.1016/j.devcel.2009.10.007</a>.","short":"M. Hetzer, S.R. Wente, Developmental Cell 17 (2009) 606–616."},"year":"2009","external_id":{"pmid":["19922866"]},"doi":"10.1016/j.devcel.2009.10.007","day":"17","abstract":[{"text":"Over the last decade, the nuclear envelope (NE) has emerged as a key component in the organization and function of the nuclear genome. As many as 100 different proteins are thought to specifically localize to this double membrane that separates the cytoplasm and the nucleoplasm of eukaryotic cells. Selective portals through the NE are formed at sites where the inner and outer nuclear membranes are fused, and the coincident assembly of ∼30 proteins into nuclear pore complexes occurs. These nuclear pore complexes are essential for the control of nucleocytoplasmic exchange. Many of the NE and nuclear pore proteins are thought to play crucial roles in gene regulation and thus are increasingly linked to human diseases.","lang":"eng"}],"volume":17,"extern":"1","_id":"11103","pmid":1,"scopus_import":"1","author":[{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER"},{"last_name":"Wente","first_name":"Susan R.","full_name":"Wente, Susan R."}],"issue":"5","publication_status":"published","article_processing_charge":"No","date_created":"2022-04-07T07:53:45Z","title":"Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes","intvolume":"        17","page":"606-616","quality_controlled":"1","publisher":"Elsevier","article_type":"review"},{"volume":10,"extern":"1","citation":{"mla":"Capelson, Maya, and Martin Hetzer. “The Role of Nuclear Pores in Gene Regulation, Development and Disease.” <i>EMBO Reports</i>, vol. 10, no. 7, EMBO, 2009, pp. 697–705, doi:<a href=\"https://doi.org/10.1038/embor.2009.147\">10.1038/embor.2009.147</a>.","short":"M. Capelson, M. Hetzer, EMBO Reports 10 (2009) 697–705.","ista":"Capelson M, Hetzer M. 2009. The role of nuclear pores in gene regulation, development and disease. EMBO reports. 10(7), 697–705.","ama":"Capelson M, Hetzer M. The role of nuclear pores in gene regulation, development and disease. <i>EMBO reports</i>. 2009;10(7):697-705. doi:<a href=\"https://doi.org/10.1038/embor.2009.147\">10.1038/embor.2009.147</a>","apa":"Capelson, M., &#38; Hetzer, M. (2009). The role of nuclear pores in gene regulation, development and disease. <i>EMBO Reports</i>. EMBO. <a href=\"https://doi.org/10.1038/embor.2009.147\">https://doi.org/10.1038/embor.2009.147</a>","ieee":"M. Capelson and M. Hetzer, “The role of nuclear pores in gene regulation, development and disease,” <i>EMBO reports</i>, vol. 10, no. 7. EMBO, pp. 697–705, 2009.","chicago":"Capelson, Maya, and Martin Hetzer. “The Role of Nuclear Pores in Gene Regulation, Development and Disease.” <i>EMBO Reports</i>. EMBO, 2009. <a href=\"https://doi.org/10.1038/embor.2009.147\">https://doi.org/10.1038/embor.2009.147</a>."},"year":"2009","date_updated":"2022-07-18T08:42:44Z","external_id":{"pmid":["19543230"]},"day":"01","doi":"10.1038/embor.2009.147","abstract":[{"text":"Nuclear-pore complexes (NPCs) are large protein channels that span the nuclear envelope (NE), which is a double membrane that encloses the nuclear genome of eukaryotes. Each of the typically 2,000–4,000 pores in the NE of vertebrate cells is composed of multiple copies of 30 different proteins known as nucleoporins. The evolutionarily conserved NPC proteins have the well-characterized function of mediating the transport of molecules between the nucleoplasm and the cytoplasm. Mutations in nucleoporins are often linked to specific developmental defects and disease, and the resulting phenotypes are usually interpreted as the consequences of perturbed nuclear transport activity. However, recent evidence suggests that NPCs have additional functions in chromatin organization and gene regulation, some of which might be independent of nuclear transport. Here, we review the transport-dependent and transport-independent roles of NPCs in the regulation of nuclear function and gene expression.","lang":"eng"}],"quality_controlled":"1","page":"697-705","publisher":"EMBO","article_type":"original","scopus_import":"1","pmid":1,"_id":"11105","issue":"7","author":[{"full_name":"Capelson, Maya","last_name":"Capelson","first_name":"Maya"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"}],"date_created":"2022-04-07T07:54:06Z","article_processing_charge":"No","publication_status":"published","intvolume":"        10","title":"The role of nuclear pores in gene regulation, development and disease","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/embor.2009.147"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public","related_material":{"link":[{"url":"https://doi.org/10.1038/embor.2009.176","relation":"erratum"}]},"type":"journal_article","date_published":"2009-07-01T00:00:00Z","publication_identifier":{"issn":["1469-221X"],"eissn":["1469-3178"]},"oa":1,"keyword":["Genetics","Molecular Biology","Biochemistry"],"language":[{"iso":"eng"}],"publication":"EMBO reports","oa_version":"Published Version","month":"07"},{"publication":"Cell","month":"01","oa_version":"Published Version","keyword":["General Biochemistry","Genetics and Molecular Biology"],"language":[{"iso":"eng"}],"type":"journal_article","date_published":"2009-01-23T00:00:00Z","oa":1,"publication_identifier":{"issn":["0092-8674"]},"status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cell.2008.11.037"}],"issue":"2","author":[{"first_name":"Maximiliano A.","last_name":"D'Angelo","full_name":"D'Angelo, Maximiliano A."},{"last_name":"Raices","first_name":"Marcela","full_name":"Raices, Marcela"},{"full_name":"Panowski, Siler H.","last_name":"Panowski","first_name":"Siler H."},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER"}],"scopus_import":"1","pmid":1,"_id":"11108","intvolume":"       136","title":"Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells","date_created":"2022-04-07T07:54:52Z","article_processing_charge":"No","publication_status":"published","quality_controlled":"1","page":"284-295","article_type":"original","publisher":"Elsevier","external_id":{"pmid":["19167330"]},"citation":{"short":"M.A. D’Angelo, M. Raices, S.H. Panowski, M. Hetzer, Cell 136 (2009) 284–295.","mla":"D’Angelo, Maximiliano A., et al. “Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells.” <i>Cell</i>, vol. 136, no. 2, Elsevier, 2009, pp. 284–95, doi:<a href=\"https://doi.org/10.1016/j.cell.2008.11.037\">10.1016/j.cell.2008.11.037</a>.","ista":"D’Angelo MA, Raices M, Panowski SH, Hetzer M. 2009. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 136(2), 284–295.","ama":"D’Angelo MA, Raices M, Panowski SH, Hetzer M. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. <i>Cell</i>. 2009;136(2):284-295. doi:<a href=\"https://doi.org/10.1016/j.cell.2008.11.037\">10.1016/j.cell.2008.11.037</a>","apa":"D’Angelo, M. A., Raices, M., Panowski, S. H., &#38; Hetzer, M. (2009). Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2008.11.037\">https://doi.org/10.1016/j.cell.2008.11.037</a>","ieee":"M. A. D’Angelo, M. Raices, S. H. Panowski, and M. Hetzer, “Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells,” <i>Cell</i>, vol. 136, no. 2. Elsevier, pp. 284–295, 2009.","chicago":"D’Angelo, Maximiliano A., Marcela Raices, Siler H. Panowski, and Martin Hetzer. “Age-Dependent Deterioration of Nuclear Pore Complexes Causes a Loss of Nuclear Integrity in Postmitotic Cells.” <i>Cell</i>. Elsevier, 2009. <a href=\"https://doi.org/10.1016/j.cell.2008.11.037\">https://doi.org/10.1016/j.cell.2008.11.037</a>."},"year":"2009","date_updated":"2022-07-18T08:55:29Z","abstract":[{"lang":"eng","text":"In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC components, like Nup153 and Nup50, are continuously exchanged, scaffold nucleoporins, like the Nup107/160 complex, are extremely long-lived and remain incorporated in the nuclear membrane during the entire cellular life span. Besides the lack of nucleoporin expression and NPC turnover, we discovered an age-related deterioration of NPCs, leading to an increase in nuclear permeability and the leaking of cytoplasmic proteins into the nucleus. Our finding that nuclear “leakiness” is dramatically accelerated during aging and that a subset of nucleoporins is oxidatively damaged in old cells suggests that the accumulation of damage at the NPC might be a crucial aging event."}],"day":"23","doi":"10.1016/j.cell.2008.11.037","extern":"1","volume":136},{"status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/sj.embor.7400889"}],"oa":1,"publication_identifier":{"eissn":["1469-3178"],"issn":["1469-221X"]},"date_published":"2007-01-19T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"keyword":["Genetics","Molecular Biology","Biochemistry"],"month":"01","oa_version":"Published Version","publication":"EMBO reports","extern":"1","volume":8,"abstract":[{"text":"The metazoan nuclear envelope (NE) breaks down and re-forms during each cell cycle. Nuclear pore complexes (NPCs), which allow nucleocytoplasmic transport during interphase, assemble into the re-forming NE at the end of mitosis. Using in vitro NE assembly, we show that the vertebrate homologue of MEL-28 (maternal effect lethal), a recently discovered NE component in Caenorhabditis elegans, functions in postmitotic NPC assembly. MEL-28 interacts with the Nup107–160 complex (Nup for nucleoporin), an important building block of the NPC, and is essential for the recruitment of the Nup107–160 complex to chromatin. We suggest that MEL-28 acts as a seeding point for NPC assembly.","lang":"eng"}],"doi":"10.1038/sj.embor.7400889","day":"19","external_id":{"pmid":["17235358"]},"date_updated":"2022-07-18T08:56:40Z","year":"2007","citation":{"ista":"Franz C, Walczak R, Yavuz S, Santarella R, Gentzel M, Askjaer P, Galy V, Hetzer M, Mattaj IW, Antonin W. 2007. MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. EMBO reports. 8(2), 165–172.","short":"C. Franz, R. Walczak, S. Yavuz, R. Santarella, M. Gentzel, P. Askjaer, V. Galy, M. Hetzer, I.W. Mattaj, W. Antonin, EMBO Reports 8 (2007) 165–172.","mla":"Franz, Cerstin, et al. “MEL‐28/ELYS Is Required for the Recruitment of Nucleoporins to Chromatin and Postmitotic Nuclear Pore Complex Assembly.” <i>EMBO Reports</i>, vol. 8, no. 2, EMBO, 2007, pp. 165–72, doi:<a href=\"https://doi.org/10.1038/sj.embor.7400889\">10.1038/sj.embor.7400889</a>.","chicago":"Franz, Cerstin, Rudolf Walczak, Sevil Yavuz, Rachel Santarella, Marc Gentzel, Peter Askjaer, Vincent Galy, Martin Hetzer, Iain W Mattaj, and Wolfram Antonin. “MEL‐28/ELYS Is Required for the Recruitment of Nucleoporins to Chromatin and Postmitotic Nuclear Pore Complex Assembly.” <i>EMBO Reports</i>. EMBO, 2007. <a href=\"https://doi.org/10.1038/sj.embor.7400889\">https://doi.org/10.1038/sj.embor.7400889</a>.","ieee":"C. Franz <i>et al.</i>, “MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly,” <i>EMBO reports</i>, vol. 8, no. 2. EMBO, pp. 165–172, 2007.","apa":"Franz, C., Walczak, R., Yavuz, S., Santarella, R., Gentzel, M., Askjaer, P., … Antonin, W. (2007). MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. <i>EMBO Reports</i>. EMBO. <a href=\"https://doi.org/10.1038/sj.embor.7400889\">https://doi.org/10.1038/sj.embor.7400889</a>","ama":"Franz C, Walczak R, Yavuz S, et al. MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly. <i>EMBO reports</i>. 2007;8(2):165-172. doi:<a href=\"https://doi.org/10.1038/sj.embor.7400889\">10.1038/sj.embor.7400889</a>"},"article_type":"original","publisher":"EMBO","page":"165-172","quality_controlled":"1","title":"MEL‐28/ELYS is required for the recruitment of nucleoporins to chromatin and postmitotic nuclear pore complex assembly","intvolume":"         8","publication_status":"published","article_processing_charge":"No","date_created":"2022-04-07T07:56:13Z","author":[{"first_name":"Cerstin","last_name":"Franz","full_name":"Franz, Cerstin"},{"full_name":"Walczak, Rudolf","last_name":"Walczak","first_name":"Rudolf"},{"first_name":"Sevil","last_name":"Yavuz","full_name":"Yavuz, Sevil"},{"full_name":"Santarella, Rachel","last_name":"Santarella","first_name":"Rachel"},{"last_name":"Gentzel","first_name":"Marc","full_name":"Gentzel, Marc"},{"full_name":"Askjaer, Peter","first_name":"Peter","last_name":"Askjaer"},{"full_name":"Galy, Vincent","last_name":"Galy","first_name":"Vincent"},{"orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"},{"full_name":"Mattaj, Iain W","first_name":"Iain W","last_name":"Mattaj"},{"first_name":"Wolfram","last_name":"Antonin","full_name":"Antonin, Wolfram"}],"issue":"2","pmid":1,"_id":"11116","scopus_import":"1"},{"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_published":"2007-10-01T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0168-9525"]},"language":[{"iso":"eng"}],"keyword":["Genetics"],"publication":"Trends in Genetics","oa_version":"None","month":"10","acknowledgement":"X.F. holds a Clarendon Scholarship from the University of Oxford. We thank Angela Hay and Jill Harrison for helpful advice and discussion.","volume":23,"extern":"1","date_updated":"2023-05-08T10:58:47Z","citation":{"apa":"Feng, X., &#38; Dickinson, H. G. (2007). Packaging the male germline in plants. <i>Trends in Genetics</i>. Elsevier BV. <a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">https://doi.org/10.1016/j.tig.2007.08.005</a>","ama":"Feng X, Dickinson HG. Packaging the male germline in plants. <i>Trends in Genetics</i>. 2007;23(10):503-510. doi:<a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">10.1016/j.tig.2007.08.005</a>","chicago":"Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.” <i>Trends in Genetics</i>. Elsevier BV, 2007. <a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">https://doi.org/10.1016/j.tig.2007.08.005</a>.","ieee":"X. Feng and H. G. Dickinson, “Packaging the male germline in plants,” <i>Trends in Genetics</i>, vol. 23, no. 10. Elsevier BV, pp. 503–510, 2007.","mla":"Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.” <i>Trends in Genetics</i>, vol. 23, no. 10, Elsevier BV, 2007, pp. 503–10, doi:<a href=\"https://doi.org/10.1016/j.tig.2007.08.005\">10.1016/j.tig.2007.08.005</a>.","short":"X. Feng, H.G. Dickinson, Trends in Genetics 23 (2007) 503–510.","ista":"Feng X, Dickinson HG. 2007. Packaging the male germline in plants. Trends in Genetics. 23(10), 503–510."},"year":"2007","external_id":{"pmid":["17825943"]},"doi":"10.1016/j.tig.2007.08.005","abstract":[{"text":"The development of plant lateral organs is interesting because, although many of the same genes seem to be involved in the early growth of primordia, completely different gene combinations are required for the complete development of organs such as leaves and stamens. Thus, the genes common to the development of most organs, which generally form and polarize the primordial ‘envelope’, must at some stage interact with those that ‘install’ the functional content of the organ – in the case of the stamen, the four microsporangia. Although distinct genetic pathways of organ initiation, polarity establishment and setting up the reproductive cell line can readily be recognized, they do not occur sequentially. Rather, they are activated early and run in parallel. There is evidence for continuing crosstalk between these pathways.","lang":"eng"}],"page":"503-510","quality_controlled":"1","publisher":"Elsevier BV","article_type":"original","_id":"12201","pmid":1,"scopus_import":"1","author":[{"id":"e0164712-22ee-11ed-b12a-d80fcdf35958","last_name":"Feng","first_name":"Xiaoqi","full_name":"Feng, Xiaoqi","orcid":"0000-0002-4008-1234"},{"full_name":"Dickinson, Hugh G.","first_name":"Hugh G.","last_name":"Dickinson"}],"issue":"10","publication_status":"published","department":[{"_id":"XiFe"}],"article_processing_charge":"No","date_created":"2023-01-16T09:22:44Z","title":"Packaging the male germline in plants","intvolume":"        23"},{"publication":"DNA Sequence","oa_version":"None","language":[{"iso":"eng"}],"keyword":["Endocrinology","Genetics","Molecular Biology","Biochemistry"],"date_published":"2004-01-01T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["1042-5179"]},"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"last_name":"Liao","first_name":"Zhihua","full_name":"Liao, Zhihua"},{"first_name":"Min","last_name":"Chen","full_name":"Chen, Min"},{"full_name":"Gong, Yifu","last_name":"Gong","first_name":"Yifu"},{"full_name":"Guo, Liang","first_name":"Liang","last_name":"Guo"},{"full_name":"Tan, Qiumin","last_name":"Tan","first_name":"Qiumin"},{"id":"e0164712-22ee-11ed-b12a-d80fcdf35958","full_name":"Feng, Xiaoqi","orcid":"0000-0002-4008-1234","last_name":"Feng","first_name":"Xiaoqi"},{"full_name":"Sun, Xiaofen","last_name":"Sun","first_name":"Xiaofen"},{"last_name":"Tan","first_name":"Feng","full_name":"Tan, Feng"},{"first_name":"Kexuan","last_name":"Tang","full_name":"Tang, Kexuan"}],"issue":"2","_id":"12203","pmid":1,"scopus_import":"1","title":"A new geranylgeranyl Diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides","intvolume":"        15","publication_status":"published","department":[{"_id":"XiFe"}],"article_processing_charge":"No","date_created":"2023-01-16T09:24:50Z","page":"153-158","quality_controlled":"1","article_type":"original","publisher":"Informa UK Limited","external_id":{"pmid":["15352294"]},"date_updated":"2023-05-08T10:58:29Z","citation":{"apa":"Liao, Z., Chen, M., Gong, Y., Guo, L., Tan, Q., Feng, X., … Tang, K. (2004). A new geranylgeranyl Diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides. <i>DNA Sequence</i>. Informa UK Limited. <a href=\"https://doi.org/10.1080/10425170410001667348\">https://doi.org/10.1080/10425170410001667348</a>","ama":"Liao Z, Chen M, Gong Y, et al. A new geranylgeranyl Diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides. <i>DNA Sequence</i>. 2004;15(2):153-158. doi:<a href=\"https://doi.org/10.1080/10425170410001667348\">10.1080/10425170410001667348</a>","ieee":"Z. Liao <i>et al.</i>, “A new geranylgeranyl Diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides,” <i>DNA Sequence</i>, vol. 15, no. 2. Informa UK Limited, pp. 153–158, 2004.","chicago":"Liao, Zhihua, Min Chen, Yifu Gong, Liang Guo, Qiumin Tan, Xiaoqi Feng, Xiaofen Sun, Feng Tan, and Kexuan Tang. “A New Geranylgeranyl Diphosphate Synthase Gene from Ginkgo Biloba, Which Intermediates the Biosynthesis of the Key Precursor for Ginkgolides.” <i>DNA Sequence</i>. Informa UK Limited, 2004. <a href=\"https://doi.org/10.1080/10425170410001667348\">https://doi.org/10.1080/10425170410001667348</a>.","short":"Z. Liao, M. Chen, Y. Gong, L. Guo, Q. Tan, X. Feng, X. Sun, F. Tan, K. Tang, DNA Sequence 15 (2004) 153–158.","mla":"Liao, Zhihua, et al. “A New Geranylgeranyl Diphosphate Synthase Gene from Ginkgo Biloba, Which Intermediates the Biosynthesis of the Key Precursor for Ginkgolides.” <i>DNA Sequence</i>, vol. 15, no. 2, Informa UK Limited, 2004, pp. 153–58, doi:<a href=\"https://doi.org/10.1080/10425170410001667348\">10.1080/10425170410001667348</a>.","ista":"Liao Z, Chen M, Gong Y, Guo L, Tan Q, Feng X, Sun X, Tan F, Tang K. 2004. A new geranylgeranyl Diphosphate synthase gene from Ginkgo biloba, which intermediates the biosynthesis of the key precursor for ginkgolides. DNA Sequence. 15(2), 153–158."},"year":"2004","abstract":[{"text":"Geranylgeranyl diphosphate synthase (GGPPS, EC: 2.5.1.29) catalyzes the biosynthesis of geranylgeranyl diphosphate (GGPP), which is a key precursor for ginkgolide biosynthesis. Here we reported for the first time the cloning of a new full-length cDNA encoding GGPPS from the living fossil plant Ginkgo biloba. The full-length cDNA encoding G. biloba GGPPS (designated as GbGGPPS) was 1657bp long and contained a 1176bp open reading frame encoding a 391 amino acid protein. Comparative analysis showed that GbGGPPS possessed a 79 amino acid transit peptide at its N-terminal, which directed GbGGPPS to target to the plastids. Bioinformatic analysis revealed that GbGGPPS was a member of polyprenyltransferases with two highly conserved aspartate-rich motifs like other plant GGPPSs. Phylogenetic tree analysis indicated that plant GGPPSs could be classified into two groups, angiosperm and gymnosperm GGPPSs, while GbGGPPS had closer relationship with gymnosperm plant GGPPSs.","lang":"eng"}],"doi":"10.1080/10425170410001667348","extern":"1","acknowledgement":"This study was financially supported by China National High-Tech “863” Program. The authors are very thankful to Dr Li Wang (School of Life Sciences, Fudan University, Shanghai, China) for her kind help with constructing the phylogenetic tree.","volume":15},{"issue":"2","author":[{"last_name":"Walther","first_name":"Tobias C.","full_name":"Walther, Tobias C."},{"full_name":"Alves, Annabelle","first_name":"Annabelle","last_name":"Alves"},{"last_name":"Pickersgill","first_name":"Helen","full_name":"Pickersgill, Helen"},{"full_name":"Loı̈odice, Isabelle","first_name":"Isabelle","last_name":"Loı̈odice"},{"first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"},{"first_name":"Vincent","last_name":"Galy","full_name":"Galy, Vincent"},{"full_name":"Hülsmann, Bastian B.","first_name":"Bastian B.","last_name":"Hülsmann"},{"full_name":"Köcher, Thomas","last_name":"Köcher","first_name":"Thomas"},{"first_name":"Matthias","last_name":"Wilm","full_name":"Wilm, Matthias"},{"full_name":"Allen, Terry","last_name":"Allen","first_name":"Terry"},{"last_name":"Mattaj","first_name":"Iain W.","full_name":"Mattaj, Iain W."},{"first_name":"Valérie","last_name":"Doye","full_name":"Doye, Valérie"}],"scopus_import":"1","_id":"11122","pmid":1,"intvolume":"       113","title":"The conserved Nup107-160 complex is critical for nuclear pore complex assembly","article_processing_charge":"No","date_created":"2022-04-07T07:57:10Z","publication_status":"published","quality_controlled":"1","page":"195-206","article_type":"original","publisher":"Elsevier","external_id":{"pmid":["12705868"]},"year":"2003","citation":{"ama":"Walther TC, Alves A, Pickersgill H, et al. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. <i>Cell</i>. 2003;113(2):195-206. doi:<a href=\"https://doi.org/10.1016/s0092-8674(03)00235-6\">10.1016/s0092-8674(03)00235-6</a>","apa":"Walther, T. C., Alves, A., Pickersgill, H., Loı̈odice, I., Hetzer, M., Galy, V., … Doye, V. (2003). The conserved Nup107-160 complex is critical for nuclear pore complex assembly. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/s0092-8674(03)00235-6\">https://doi.org/10.1016/s0092-8674(03)00235-6</a>","chicago":"Walther, Tobias C., Annabelle Alves, Helen Pickersgill, Isabelle Loı̈odice, Martin Hetzer, Vincent Galy, Bastian B. Hülsmann, et al. “The Conserved Nup107-160 Complex Is Critical for Nuclear Pore Complex Assembly.” <i>Cell</i>. Elsevier, 2003. <a href=\"https://doi.org/10.1016/s0092-8674(03)00235-6\">https://doi.org/10.1016/s0092-8674(03)00235-6</a>.","ieee":"T. C. Walther <i>et al.</i>, “The conserved Nup107-160 complex is critical for nuclear pore complex assembly,” <i>Cell</i>, vol. 113, no. 2. Elsevier, pp. 195–206, 2003.","mla":"Walther, Tobias C., et al. “The Conserved Nup107-160 Complex Is Critical for Nuclear Pore Complex Assembly.” <i>Cell</i>, vol. 113, no. 2, Elsevier, 2003, pp. 195–206, doi:<a href=\"https://doi.org/10.1016/s0092-8674(03)00235-6\">10.1016/s0092-8674(03)00235-6</a>.","short":"T.C. Walther, A. Alves, H. Pickersgill, I. Loı̈odice, M. Hetzer, V. Galy, B.B. Hülsmann, T. Köcher, M. Wilm, T. Allen, I.W. Mattaj, V. Doye, Cell 113 (2003) 195–206.","ista":"Walther TC, Alves A, Pickersgill H, Loı̈odice I, Hetzer M, Galy V, Hülsmann BB, Köcher T, Wilm M, Allen T, Mattaj IW, Doye V. 2003. The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell. 113(2), 195–206."},"date_updated":"2022-07-18T08:57:42Z","abstract":[{"text":"Nuclear pore complexes (NPCs) are large multiprotein assemblies that allow traffic between the cytoplasm and the nucleus. During mitosis in higher eukaryotes, the Nuclear Envelope (NE) breaks down and NPCs disassemble. How NPCs reassemble and incorporate into the NE upon mitotic exit is poorly understood. We demonstrate a function for the conserved Nup107-160 complex in this process. Partial in vivo depletion of Nup133 or Nup107 via RNAi in HeLa cells resulted in reduced levels of multiple nucleoporins and decreased NPC density in the NE. Immunodepletion of the entire Nup107-160 complex from in vitro nuclear assembly reactions produced nuclei with a continuous NE but no NPCs. This phenotype was reversible only if Nup107-160 complex was readded before closed NE formation. Depletion also prevented association of FG-repeat nucleoporins with chromatin. We propose a stepwise model in which postmitotic NPC assembly initiates on chromatin via early recruitment of the Nup107-160 complex.","lang":"eng"}],"day":"17","doi":"10.1016/s0092-8674(03)00235-6","extern":"1","volume":113,"publication":"Cell","month":"04","oa_version":"Published Version","keyword":["General Biochemistry","Genetics and Molecular Biology"],"language":[{"iso":"eng"}],"type":"journal_article","date_published":"2003-04-17T00:00:00Z","publication_identifier":{"issn":["0092-8674"]},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public"},{"type":"journal_article","date_published":"2002-07-09T00:00:00Z","publication_identifier":{"issn":["0960-9822"]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.1016/S0960-9822(02)00927-2","open_access":"1"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public","publication":"Current Biology","oa_version":"Published Version","month":"07","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"language":[{"iso":"eng"}],"citation":{"short":"D. Bilbao-Cortés, M. Hetzer, G. Längst, P.B. Becker, I.W. Mattaj, Current Biology 12 (2002) 1151–1156.","mla":"Bilbao-Cortés, Daniel, et al. “Ran Binds to Chromatin by Two Distinct Mechanisms.” <i>Current Biology</i>, vol. 12, no. 13, Elsevier BV, 2002, pp. 1151–56, doi:<a href=\"https://doi.org/10.1016/s0960-9822(02)00927-2\">10.1016/s0960-9822(02)00927-2</a>.","ista":"Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. 2002. Ran binds to chromatin by two distinct mechanisms. Current Biology. 12(13), 1151–1156.","apa":"Bilbao-Cortés, D., Hetzer, M., Längst, G., Becker, P. B., &#38; Mattaj, I. W. (2002). Ran binds to chromatin by two distinct mechanisms. <i>Current Biology</i>. Elsevier BV. <a href=\"https://doi.org/10.1016/s0960-9822(02)00927-2\">https://doi.org/10.1016/s0960-9822(02)00927-2</a>","ama":"Bilbao-Cortés D, Hetzer M, Längst G, Becker PB, Mattaj IW. Ran binds to chromatin by two distinct mechanisms. <i>Current Biology</i>. 2002;12(13):1151-1156. doi:<a href=\"https://doi.org/10.1016/s0960-9822(02)00927-2\">10.1016/s0960-9822(02)00927-2</a>","ieee":"D. Bilbao-Cortés, M. Hetzer, G. Längst, P. B. Becker, and I. W. Mattaj, “Ran binds to chromatin by two distinct mechanisms,” <i>Current Biology</i>, vol. 12, no. 13. Elsevier BV, pp. 1151–1156, 2002.","chicago":"Bilbao-Cortés, Daniel, Martin Hetzer, Gernot Längst, Peter B. Becker, and Iain W. Mattaj. “Ran Binds to Chromatin by Two Distinct Mechanisms.” <i>Current Biology</i>. Elsevier BV, 2002. <a href=\"https://doi.org/10.1016/s0960-9822(02)00927-2\">https://doi.org/10.1016/s0960-9822(02)00927-2</a>."},"year":"2002","date_updated":"2022-07-18T08:58:05Z","external_id":{"pmid":["12121625"]},"day":"09","doi":"10.1016/s0960-9822(02)00927-2","abstract":[{"lang":"eng","text":"Ran GTPase plays important roles in nucleocytoplasmic transport in interphase [1, 2] and in both spindle formation and nuclear envelope (NE) assembly during mitosis [3, 4, 5]. The latter functions rely on the presence of high local concentrations of GTP-bound Ran near mitotic chromatin [3, 4, 5]. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin [6, 7, 8, 9], but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes. We propose that the Ran binding capacity of chromatin contributes to localized spindle and NE assembly."}],"volume":12,"extern":"1","scopus_import":"1","pmid":1,"_id":"11124","issue":"13","author":[{"first_name":"Daniel","last_name":"Bilbao-Cortés","full_name":"Bilbao-Cortés, Daniel"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"},{"last_name":"Längst","first_name":"Gernot","full_name":"Längst, Gernot"},{"first_name":"Peter B.","last_name":"Becker","full_name":"Becker, Peter B."},{"full_name":"Mattaj, Iain W.","first_name":"Iain W.","last_name":"Mattaj"}],"article_processing_charge":"No","date_created":"2022-04-07T07:57:31Z","publication_status":"published","intvolume":"        12","title":"Ran binds to chromatin by two distinct mechanisms","quality_controlled":"1","page":"1151-1156","publisher":"Elsevier BV","article_type":"letter_note"}]