[{"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy"],"publication":"SciPost Physics","has_accepted_license":"1","oa_version":"Published Version","project":[{"_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411","name":"ISTplus - Postdoctoral Fellowships"}],"month":"09","article_number":"048","file":[{"file_name":"2021_SciPostPhys_DeNicola.pdf","content_type":"application/pdf","date_updated":"2021-09-02T14:05:43Z","file_size":373833,"checksum":"e4ec69d893e31811efc6093cb6ea8eb7","date_created":"2021-09-02T14:05:43Z","creator":"cchlebak","file_id":"9984","relation":"main_file","success":1,"access_level":"open_access"}],"status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2021-09-02T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["2542-4653"],"eissn":["2666-9366"]},"oa":1,"ec_funded":1,"quality_controlled":"1","file_date_updated":"2021-09-02T14:05:43Z","publisher":"SciPost","article_type":"original","_id":"9981","license":"https://creativecommons.org/licenses/by/4.0/","author":[{"orcid":"0000-0002-4842-6671","full_name":"De Nicola, Stefano","first_name":"Stefano","last_name":"De Nicola","id":"42832B76-F248-11E8-B48F-1D18A9856A87"}],"issue":"3","publication_status":"published","department":[{"_id":"MaSe"}],"date_created":"2021-09-02T11:49:47Z","article_processing_charge":"No","title":"Importance sampling scheme for the stochastic simulation of quantum spin dynamics","intvolume":"        11","volume":11,"ddc":["519"],"date_updated":"2023-08-11T10:59:29Z","year":"2021","citation":{"ista":"De Nicola S. 2021. Importance sampling scheme for the stochastic simulation of quantum spin dynamics. SciPost Physics. 11(3), 048.","mla":"De Nicola, Stefano. “Importance Sampling Scheme for the Stochastic Simulation of Quantum Spin Dynamics.” <i>SciPost Physics</i>, vol. 11, no. 3, 048, SciPost, 2021, doi:<a href=\"https://doi.org/10.21468/scipostphys.11.3.048\">10.21468/scipostphys.11.3.048</a>.","short":"S. De Nicola, SciPost Physics 11 (2021).","chicago":"De Nicola, Stefano. “Importance Sampling Scheme for the Stochastic Simulation of Quantum Spin Dynamics.” <i>SciPost Physics</i>. SciPost, 2021. <a href=\"https://doi.org/10.21468/scipostphys.11.3.048\">https://doi.org/10.21468/scipostphys.11.3.048</a>.","ieee":"S. De Nicola, “Importance sampling scheme for the stochastic simulation of quantum spin dynamics,” <i>SciPost Physics</i>, vol. 11, no. 3. SciPost, 2021.","ama":"De Nicola S. Importance sampling scheme for the stochastic simulation of quantum spin dynamics. <i>SciPost Physics</i>. 2021;11(3). doi:<a href=\"https://doi.org/10.21468/scipostphys.11.3.048\">10.21468/scipostphys.11.3.048</a>","apa":"De Nicola, S. (2021). Importance sampling scheme for the stochastic simulation of quantum spin dynamics. <i>SciPost Physics</i>. SciPost. <a href=\"https://doi.org/10.21468/scipostphys.11.3.048\">https://doi.org/10.21468/scipostphys.11.3.048</a>"},"isi":1,"external_id":{"arxiv":["2103.16468"],"isi":["000692534200001"]},"arxiv":1,"doi":"10.21468/scipostphys.11.3.048","day":"02","abstract":[{"lang":"eng","text":"The numerical simulation of dynamical phenomena in interacting quantum systems is a notoriously hard problem. Although a number of promising numerical methods exist, they often have limited applicability due to the growth of entanglement or the presence of the so-called sign problem. In this work, we develop an importance sampling scheme for the simulation of quantum spin dynamics, building on a recent approach mapping quantum spin systems to classical stochastic processes. The importance sampling scheme is based on identifying the classical trajectory that yields the largest contribution to a given quantum observable. An exact transformation is then carried out to preferentially sample trajectories that are close to the dominant one. We demonstrate that this approach is capable of reducing the temporal growth of fluctuations in the stochastic quantities, thus extending the range of accessible times and system sizes compared to direct sampling. We discuss advantages and limitations of the proposed approach, outlining directions\r\nfor further developments."}]},{"acknowledgement":"We thank Yuan Chen for performing supplementary FEM simulations and Andrew Higginbotham, Ralf Riedinger, Sungkun Hong, and Lorenzo Magrini for valuable discussions. This work was supported by IST Austria, the IST nanofabrication facility (NFF), the European Union’s Horizon 2020 research and innovation program under grant agreement no. 732894 (FET Proactive HOT) and the European Research Council under grant agreement no. 758053 (ERC StG QUNNECT). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 754411. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (F71), a NOMIS foundation research grant, and the EU’s Horizon 2020 research and innovation program under grant agreement no. 862644 (FET Open QUARTET).","volume":11,"ddc":["530"],"date_updated":"2024-08-07T07:11:51Z","citation":{"short":"G.M. Arnold, M. Wulf, S. Barzanjeh, E. Redchenko, A.R. Rueda Sanchez, W.J. Hease, F. Hassani, J.M. Fink, Nature Communications 11 (2020).","mla":"Arnold, Georg M., et al. “Converting Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.” <i>Nature Communications</i>, vol. 11, 4460, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18269-z\">10.1038/s41467-020-18269-z</a>.","ista":"Arnold GM, Wulf M, Barzanjeh S, Redchenko E, Rueda Sanchez AR, Hease WJ, Hassani F, Fink JM. 2020. Converting microwave and telecom photons with a silicon photonic nanomechanical interface. Nature Communications. 11, 4460.","apa":"Arnold, G. M., Wulf, M., Barzanjeh, S., Redchenko, E., Rueda Sanchez, A. R., Hease, W. J., … Fink, J. M. (2020). Converting microwave and telecom photons with a silicon photonic nanomechanical interface. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18269-z\">https://doi.org/10.1038/s41467-020-18269-z</a>","ama":"Arnold GM, Wulf M, Barzanjeh S, et al. Converting microwave and telecom photons with a silicon photonic nanomechanical interface. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18269-z\">10.1038/s41467-020-18269-z</a>","ieee":"G. M. Arnold <i>et al.</i>, “Converting microwave and telecom photons with a silicon photonic nanomechanical interface,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","chicago":"Arnold, Georg M, Matthias Wulf, Shabir Barzanjeh, Elena Redchenko, Alfredo R Rueda Sanchez, William J Hease, Farid Hassani, and Johannes M Fink. “Converting Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18269-z\">https://doi.org/10.1038/s41467-020-18269-z</a>."},"year":"2020","isi":1,"external_id":{"isi":["000577280200001"]},"doi":"10.1038/s41467-020-18269-z","day":"08","abstract":[{"text":"Practical quantum networks require low-loss and noise-resilient optical interconnects as well as non-Gaussian resources for entanglement distillation and distributed quantum computation. The latter could be provided by superconducting circuits but existing solutions to interface the microwave and optical domains lack either scalability or efficiency, and in most cases the conversion noise is not known. In this work we utilize the unique opportunities of silicon photonics, cavity optomechanics and superconducting circuits to demonstrate a fully integrated, coherent transducer interfacing the microwave X and the telecom S bands with a total (internal) bidirectional transduction efficiency of 1.2% (135%) at millikelvin temperatures. The coupling relies solely on the radiation pressure interaction mediated by the femtometer-scale motion of two silicon nanobeams reaching a <jats:italic>V</jats:italic><jats:sub><jats:italic>π</jats:italic></jats:sub> as low as 16 μV for sub-nanowatt pump powers. Without the associated optomechanical gain, we achieve a total (internal) pure conversion efficiency of up to 0.019% (1.6%), relevant for future noise-free operation on this qubit-compatible platform.","lang":"eng"}],"quality_controlled":"1","ec_funded":1,"file_date_updated":"2020-09-18T13:02:37Z","publisher":"Springer Nature","article_type":"original","_id":"8529","author":[{"full_name":"Arnold, Georg M","orcid":"0000-0003-1397-7876","last_name":"Arnold","first_name":"Georg M","id":"3770C838-F248-11E8-B48F-1D18A9856A87"},{"id":"45598606-F248-11E8-B48F-1D18A9856A87","first_name":"Matthias","last_name":"Wulf","orcid":"0000-0001-6613-1378","full_name":"Wulf, Matthias"},{"id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0415-1423","full_name":"Barzanjeh, Shabir","first_name":"Shabir","last_name":"Barzanjeh"},{"id":"2C21D6E8-F248-11E8-B48F-1D18A9856A87","last_name":"Redchenko","first_name":"Elena","full_name":"Redchenko, Elena"},{"id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","last_name":"Rueda Sanchez","first_name":"Alfredo R","full_name":"Rueda Sanchez, Alfredo R","orcid":"0000-0001-6249-5860"},{"id":"29705398-F248-11E8-B48F-1D18A9856A87","last_name":"Hease","first_name":"William J","full_name":"Hease, William J","orcid":"0000-0001-9868-2166"},{"full_name":"Hassani, Farid","orcid":"0000-0001-6937-5773","last_name":"Hassani","first_name":"Farid","id":"2AED110C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Fink","first_name":"Johannes M","full_name":"Fink, Johannes M","orcid":"0000-0001-8112-028X","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87"}],"publication_status":"published","date_created":"2020-09-18T10:56:20Z","department":[{"_id":"JoFi"}],"article_processing_charge":"No","title":"Converting microwave and telecom photons with a silicon photonic nanomechanical interface","intvolume":"        11","file":[{"file_name":"2020_NatureComm_Arnold.pdf","content_type":"application/pdf","date_updated":"2020-09-18T13:02:37Z","checksum":"88f92544889eb18bb38e25629a422a86","file_size":1002818,"date_created":"2020-09-18T13:02:37Z","creator":"dernst","file_id":"8530","relation":"main_file","access_level":"open_access","success":1}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","related_material":{"record":[{"status":"public","relation":"research_data","id":"13056"}],"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41467-020-18912-9"},{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/how-to-transport-microwave-quantum-information-via-optical-fiber/"}]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2020-09-08T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["2041-1723"]},"oa":1,"language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"publication":"Nature Communications","has_accepted_license":"1","acknowledged_ssus":[{"_id":"NanoFab"}],"oa_version":"Published Version","project":[{"_id":"257EB838-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Hybrid Optomechanical Technologies","grant_number":"732894"},{"grant_number":"758053","name":"A Fiber Optic Transceiver for Superconducting Qubits","_id":"26336814-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"name":"ISTplus - Postdoctoral Fellowships","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"name":"Quantum readout techniques and technologies","grant_number":"862644","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","call_identifier":"H2020"},{"_id":"2671EB66-B435-11E9-9278-68D0E5697425","name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies"}],"month":"09","article_number":"4460"},{"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"language":[{"iso":"eng"}],"has_accepted_license":"1","publication":"Nature Communications","oa_version":"Published Version","article_number":"4838","month":"09","file":[{"access_level":"open_access","relation":"main_file","success":1,"creator":"dernst","file_id":"8585","checksum":"eada7bc8dd16a49390137cff882ef328","file_size":1822469,"date_created":"2020-09-28T13:16:15Z","content_type":"application/pdf","file_name":"2020_NatureComm_Prehal.pdf","date_updated":"2020-09-28T13:16:15Z"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41467-020-19720-x"}]},"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","date_published":"2020-09-24T00:00:00Z","publication_identifier":{"issn":["2041-1723"]},"oa":1,"quality_controlled":"1","file_date_updated":"2020-09-28T13:16:15Z","publisher":"Springer Nature","article_type":"original","_id":"8568","author":[{"first_name":"Christian","last_name":"Prehal","full_name":"Prehal, Christian"},{"full_name":"Fitzek, Harald","first_name":"Harald","last_name":"Fitzek"},{"first_name":"Gerald","last_name":"Kothleitner","full_name":"Kothleitner, Gerald"},{"full_name":"Presser, Volker","last_name":"Presser","first_name":"Volker"},{"full_name":"Gollas, Bernhard","last_name":"Gollas","first_name":"Bernhard"},{"first_name":"Stefan Alexander","last_name":"Freunberger","orcid":"0000-0003-2902-5319","full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"},{"full_name":"Abbas, Qamar","last_name":"Abbas","first_name":"Qamar"}],"date_created":"2020-09-25T07:23:13Z","article_processing_charge":"No","department":[{"_id":"StFr"}],"publication_status":"published","intvolume":"        11","title":"Persistent and reversible solid iodine electrodeposition in nanoporous carbons","volume":11,"ddc":["530"],"citation":{"ama":"Prehal C, Fitzek H, Kothleitner G, et al. Persistent and reversible solid iodine electrodeposition in nanoporous carbons. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18610-6\">10.1038/s41467-020-18610-6</a>","apa":"Prehal, C., Fitzek, H., Kothleitner, G., Presser, V., Gollas, B., Freunberger, S. A., &#38; Abbas, Q. (2020). Persistent and reversible solid iodine electrodeposition in nanoporous carbons. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18610-6\">https://doi.org/10.1038/s41467-020-18610-6</a>","ieee":"C. Prehal <i>et al.</i>, “Persistent and reversible solid iodine electrodeposition in nanoporous carbons,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","chicago":"Prehal, Christian, Harald Fitzek, Gerald Kothleitner, Volker Presser, Bernhard Gollas, Stefan Alexander Freunberger, and Qamar Abbas. “Persistent and Reversible Solid Iodine Electrodeposition in Nanoporous Carbons.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18610-6\">https://doi.org/10.1038/s41467-020-18610-6</a>.","mla":"Prehal, Christian, et al. “Persistent and Reversible Solid Iodine Electrodeposition in Nanoporous Carbons.” <i>Nature Communications</i>, vol. 11, 4838, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18610-6\">10.1038/s41467-020-18610-6</a>.","short":"C. Prehal, H. Fitzek, G. Kothleitner, V. Presser, B. Gollas, S.A. Freunberger, Q. Abbas, Nature Communications 11 (2020).","ista":"Prehal C, Fitzek H, Kothleitner G, Presser V, Gollas B, Freunberger SA, Abbas Q. 2020. Persistent and reversible solid iodine electrodeposition in nanoporous carbons. Nature Communications. 11, 4838."},"year":"2020","date_updated":"2023-08-22T09:37:24Z","external_id":{"isi":["000573756600004"]},"isi":1,"day":"24","doi":"10.1038/s41467-020-18610-6","abstract":[{"text":"Aqueous iodine based electrochemical energy storage is considered a potential candidate to improve sustainability and performance of current battery and supercapacitor technology. It harnesses the redox activity of iodide, iodine, and polyiodide species in the confined geometry of nanoporous carbon electrodes. However, current descriptions of the electrochemical reaction mechanism to interconvert these species are elusive. Here we show that electrochemical oxidation of iodide in nanoporous carbons forms persistent solid iodine deposits. Confinement slows down dissolution into triiodide and pentaiodide, responsible for otherwise significant self-discharge via shuttling. The main tools for these insights are in situ Raman spectroscopy and in situ small and wide-angle X-ray scattering (in situ SAXS/WAXS). In situ Raman confirms the reversible formation of triiodide and pentaiodide. In situ SAXS/WAXS indicates remarkable amounts of solid iodine deposited in the carbon nanopores. Combined with stochastic modeling, in situ SAXS allows quantifying the solid iodine volume fraction and visualizing the iodine structure on 3D lattice models at the sub-nanometer scale. Based on the derived mechanism, we demonstrate strategies for improved iodine pore filling capacity and prevention of self-discharge, applicable to hybrid supercapacitors and batteries.","lang":"eng"}]},{"volume":152,"acknowledgement":"We are grateful to Areg Ghazaryan for valuable discussions. M.L. acknowledges support from the Austrian Science Fund (FWF) under Project No. P29902-N27 and from the European Research Council (ERC) Starting Grant No. 801770 (ANGULON). G.B. acknowledges support from the Austrian Science Fund (FWF) under Project No. M2461-N27. A.D. acknowledges funding from the European Union’s Horizon 2020 research and innovation programme under the European Research Council (ERC) Grant Agreement No. 694227 and under the Marie Sklodowska-Curie Grant Agreement No. 836146. R.S. was supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy – EXC-2111 – 390814868.","abstract":[{"lang":"eng","text":"Inspired by the possibility to experimentally manipulate and enhance chemical reactivity in helium nanodroplets, we investigate the effective interaction and the resulting correlations between two diatomic molecules immersed in a bath of bosons. By analogy with the bipolaron, we introduce the biangulon quasiparticle describing two rotating molecules that align with respect to each other due to the effective attractive interaction mediated by the excitations of the bath. We study this system in different parameter regimes and apply several theoretical approaches to describe its properties. Using a Born–Oppenheimer approximation, we investigate the dependence of the effective intermolecular interaction on the rotational state of the two molecules. In the strong-coupling regime, a product-state ansatz shows that the molecules tend to have a strong alignment in the ground state. To investigate the system in the weak-coupling regime, we apply a one-phonon excitation variational ansatz, which allows us to access the energy spectrum. In comparison to the angulon quasiparticle, the biangulon shows shifted angulon instabilities and an additional spectral instability, where resonant angular momentum transfer between the molecules and the bath takes place. These features are proposed as an experimentally observable signature for the formation of the biangulon quasiparticle. Finally, by using products of single angulon and bare impurity wave functions as basis states, we introduce a diagonalization scheme that allows us to describe the transition from two separated angulons to a biangulon as a function of the distance between the two molecules."}],"arxiv":1,"doi":"10.1063/1.5144759","day":"27","isi":1,"external_id":{"arxiv":["1912.02658"],"isi":["000530448300001"]},"date_updated":"2024-08-07T07:16:53Z","year":"2020","citation":{"ista":"Li X, Yakaboylu E, Bighin G, Schmidt R, Lemeshko M, Deuchert A. 2020. Intermolecular forces and correlations mediated by a phonon bath. The Journal of Chemical Physics. 152(16), 164302.","mla":"Li, Xiang, et al. “Intermolecular Forces and Correlations Mediated by a Phonon Bath.” <i>The Journal of Chemical Physics</i>, vol. 152, no. 16, 164302, AIP Publishing, 2020, doi:<a href=\"https://doi.org/10.1063/1.5144759\">10.1063/1.5144759</a>.","short":"X. Li, E. Yakaboylu, G. Bighin, R. Schmidt, M. Lemeshko, A. Deuchert, The Journal of Chemical Physics 152 (2020).","ieee":"X. Li, E. Yakaboylu, G. Bighin, R. Schmidt, M. Lemeshko, and A. Deuchert, “Intermolecular forces and correlations mediated by a phonon bath,” <i>The Journal of Chemical Physics</i>, vol. 152, no. 16. AIP Publishing, 2020.","chicago":"Li, Xiang, Enderalp Yakaboylu, Giacomo Bighin, Richard Schmidt, Mikhail Lemeshko, and Andreas Deuchert. “Intermolecular Forces and Correlations Mediated by a Phonon Bath.” <i>The Journal of Chemical Physics</i>. AIP Publishing, 2020. <a href=\"https://doi.org/10.1063/1.5144759\">https://doi.org/10.1063/1.5144759</a>.","apa":"Li, X., Yakaboylu, E., Bighin, G., Schmidt, R., Lemeshko, M., &#38; Deuchert, A. (2020). Intermolecular forces and correlations mediated by a phonon bath. <i>The Journal of Chemical Physics</i>. AIP Publishing. <a href=\"https://doi.org/10.1063/1.5144759\">https://doi.org/10.1063/1.5144759</a>","ama":"Li X, Yakaboylu E, Bighin G, Schmidt R, Lemeshko M, Deuchert A. Intermolecular forces and correlations mediated by a phonon bath. <i>The Journal of Chemical Physics</i>. 2020;152(16). doi:<a href=\"https://doi.org/10.1063/1.5144759\">10.1063/1.5144759</a>"},"article_type":"original","publisher":"AIP Publishing","quality_controlled":"1","ec_funded":1,"title":"Intermolecular forces and correlations mediated by a phonon bath","intvolume":"       152","publication_status":"published","article_processing_charge":"No","department":[{"_id":"MiLe"},{"_id":"RoSe"}],"date_created":"2020-09-30T10:33:17Z","author":[{"first_name":"Xiang","last_name":"Li","full_name":"Li, Xiang","id":"4B7E523C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Yakaboylu","first_name":"Enderalp","full_name":"Yakaboylu, Enderalp","orcid":"0000-0001-5973-0874","id":"38CB71F6-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-8823-9777","full_name":"Bighin, Giacomo","first_name":"Giacomo","last_name":"Bighin","id":"4CA96FD4-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Schmidt","first_name":"Richard","full_name":"Schmidt, Richard"},{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","last_name":"Lemeshko","orcid":"0000-0002-6990-7802","full_name":"Lemeshko, Mikhail"},{"first_name":"Andreas","last_name":"Deuchert","orcid":"0000-0003-3146-6746","full_name":"Deuchert, Andreas","id":"4DA65CD0-F248-11E8-B48F-1D18A9856A87"}],"issue":"16","_id":"8587","status":"public","related_material":{"record":[{"relation":"dissertation_contains","id":"8958","status":"public"}]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","main_file_link":[{"url":"https://arxiv.org/abs/1912.02658","open_access":"1"}],"oa":1,"publication_identifier":{"eissn":["1089-7690"],"issn":["0021-9606"]},"date_published":"2020-04-27T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"keyword":["Physical and Theoretical Chemistry","General Physics and Astronomy"],"month":"04","article_number":"164302","oa_version":"Preprint","project":[{"call_identifier":"FWF","_id":"26031614-B435-11E9-9278-68D0E5697425","grant_number":"P29902","name":"Quantum rotations in the presence of a many-body environment"},{"grant_number":"801770","name":"Angulon: physics and applications of a new quasiparticle","_id":"2688CF98-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"name":"A path-integral approach to composite impurities","grant_number":"M02641","_id":"26986C82-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","name":"Analysis of quantum many-body systems","grant_number":"694227"}],"publication":"The Journal of Chemical Physics"},{"date_published":"2020-11-04T00:00:00Z","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"oa":1,"publication_identifier":{"issn":["2198-3844"]},"status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","file":[{"date_created":"2020-12-10T14:07:24Z","checksum":"92818c23ecc70e35acfa671f3cfb9909","file_size":7835833,"date_updated":"2020-12-10T14:07:24Z","file_name":"2020_AdvScience_Tian.pdf","content_type":"application/pdf","success":1,"access_level":"open_access","relation":"main_file","file_id":"8938","creator":"dernst"}],"publication":"Advanced Science","has_accepted_license":"1","month":"11","article_number":"2001724","oa_version":"Published Version","project":[{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","call_identifier":"H2020","_id":"260018B0-B435-11E9-9278-68D0E5697425"}],"language":[{"iso":"eng"}],"keyword":["General Engineering","General Physics and Astronomy","General Materials Science","Medicine (miscellaneous)","General Chemical Engineering","Biochemistry","Genetics and Molecular Biology (miscellaneous)"],"isi":1,"external_id":{"isi":["000573860700001"]},"date_updated":"2023-08-22T09:53:01Z","year":"2020","citation":{"mla":"Tian, Anhao, et al. “Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting.” <i>Advanced Science</i>, vol. 7, no. 21, 2001724, Wiley, 2020, doi:<a href=\"https://doi.org/10.1002/advs.202001724\">10.1002/advs.202001724</a>.","short":"A. Tian, B. Kang, B. Li, B. Qiu, W. Jiang, F. Shao, Q. Gao, R. Liu, C. Cai, R. Jing, W. Wang, P. Chen, Q. Liang, L. Bao, J. Man, Y. Wang, Y. Shi, J. Li, M. Yang, L. Wang, J. Zhang, S. Hippenmeyer, J. Zhu, X. Bian, Y. Wang, C. Liu, Advanced Science 7 (2020).","ista":"Tian A, Kang B, Li B, Qiu B, Jiang W, Shao F, Gao Q, Liu R, Cai C, Jing R, Wang W, Chen P, Liang Q, Bao L, Man J, Wang Y, Shi Y, Li J, Yang M, Wang L, Zhang J, Hippenmeyer S, Zhu J, Bian X, Wang Y, Liu C. 2020. Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting. Advanced Science. 7(21), 2001724.","apa":"Tian, A., Kang, B., Li, B., Qiu, B., Jiang, W., Shao, F., … Liu, C. (2020). Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting. <i>Advanced Science</i>. Wiley. <a href=\"https://doi.org/10.1002/advs.202001724\">https://doi.org/10.1002/advs.202001724</a>","ama":"Tian A, Kang B, Li B, et al. Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting. <i>Advanced Science</i>. 2020;7(21). doi:<a href=\"https://doi.org/10.1002/advs.202001724\">10.1002/advs.202001724</a>","ieee":"A. Tian <i>et al.</i>, “Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting,” <i>Advanced Science</i>, vol. 7, no. 21. Wiley, 2020.","chicago":"Tian, Anhao, Bo Kang, Baizhou Li, Biying Qiu, Wenhong Jiang, Fangjie Shao, Qingqing Gao, et al. “Oncogenic State and Cell Identity Combinatorially Dictate the Susceptibility of Cells within Glioma Development Hierarchy to IGF1R Targeting.” <i>Advanced Science</i>. Wiley, 2020. <a href=\"https://doi.org/10.1002/advs.202001724\">https://doi.org/10.1002/advs.202001724</a>."},"abstract":[{"text":"Glioblastoma is the most malignant cancer in the brain and currently incurable. It is urgent to identify effective targets for this lethal disease. Inhibition of such targets should suppress the growth of cancer cells and, ideally also precancerous cells for early prevention, but minimally affect their normal counterparts. Using genetic mouse models with neural stem cells (NSCs) or oligodendrocyte precursor cells (OPCs) as the cells‐of‐origin/mutation, it is shown that the susceptibility of cells within the development hierarchy of glioma to the knockout of insulin‐like growth factor I receptor (IGF1R) is determined not only by their oncogenic states, but also by their cell identities/states. Knockout of IGF1R selectively disrupts the growth of mutant and transformed, but not normal OPCs, or NSCs. The desirable outcome of IGF1R knockout on cell growth requires the mutant cells to commit to the OPC identity regardless of its development hierarchical status. At the molecular level, oncogenic mutations reprogram the cellular network of OPCs and force them to depend more on IGF1R for their growth. A new‐generation brain‐penetrable, orally available IGF1R inhibitor harnessing tumor OPCs in the brain is also developed. The findings reveal the cellular window of IGF1R targeting and establish IGF1R as an effective target for the prevention and treatment of glioblastoma.","lang":"eng"}],"doi":"10.1002/advs.202001724","day":"04","ddc":["570"],"acknowledgement":"The authors thank Drs. J. Eisen, QR. Lu, S. Duan, Z‐H. Li, W. Mo, and Q. Wu for their critical comments on the manuscript. They also thank Dr. H. Zong for providing the CKO_NG2‐CreER model. This work is supported by the National Key Research and Development Program of China, Stem Cell and Translational Research (2016YFA0101201 to C.L., 2016YFA0100303 to Y.J.W.), the National Natural Science Foundation of China (81673035 and 81972915 to C.L., 81472722 to Y.J.W.), the Science Foundation for Distinguished Young Scientists of Zhejiang Province (LR17H160001 to C.L.), Fundamental Research Funds for the Central Universities (2016QNA7023 and 2017QNA7028 to C.L.) and the Thousand Talent Program for Young Outstanding Scientists, China (to C.L.), IST Austria institutional funds (to S.H.), European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (725780 LinPro to S.H.). C.L. is a scholar of K. C. Wong Education Foundation.","volume":7,"author":[{"full_name":"Tian, Anhao","last_name":"Tian","first_name":"Anhao"},{"full_name":"Kang, Bo","last_name":"Kang","first_name":"Bo"},{"last_name":"Li","first_name":"Baizhou","full_name":"Li, Baizhou"},{"full_name":"Qiu, Biying","first_name":"Biying","last_name":"Qiu"},{"full_name":"Jiang, Wenhong","last_name":"Jiang","first_name":"Wenhong"},{"first_name":"Fangjie","last_name":"Shao","full_name":"Shao, Fangjie"},{"full_name":"Gao, Qingqing","last_name":"Gao","first_name":"Qingqing"},{"full_name":"Liu, Rui","first_name":"Rui","last_name":"Liu"},{"full_name":"Cai, Chengwei","last_name":"Cai","first_name":"Chengwei"},{"full_name":"Jing, Rui","first_name":"Rui","last_name":"Jing"},{"full_name":"Wang, Wei","last_name":"Wang","first_name":"Wei"},{"full_name":"Chen, Pengxiang","first_name":"Pengxiang","last_name":"Chen"},{"first_name":"Qinghui","last_name":"Liang","full_name":"Liang, Qinghui"},{"first_name":"Lili","last_name":"Bao","full_name":"Bao, Lili"},{"full_name":"Man, Jianghong","last_name":"Man","first_name":"Jianghong"},{"last_name":"Wang","first_name":"Yan","full_name":"Wang, Yan"},{"full_name":"Shi, Yu","first_name":"Yu","last_name":"Shi"},{"last_name":"Li","first_name":"Jin","full_name":"Li, Jin"},{"full_name":"Yang, Minmin","last_name":"Yang","first_name":"Minmin"},{"full_name":"Wang, Lisha","last_name":"Wang","first_name":"Lisha"},{"full_name":"Zhang, Jianmin","first_name":"Jianmin","last_name":"Zhang"},{"first_name":"Simon","last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Zhu, Junming","last_name":"Zhu","first_name":"Junming"},{"full_name":"Bian, Xiuwu","first_name":"Xiuwu","last_name":"Bian"},{"full_name":"Wang, Ying‐Jie","first_name":"Ying‐Jie","last_name":"Wang"},{"first_name":"Chong","last_name":"Liu","full_name":"Liu, Chong"}],"issue":"21","_id":"8592","title":"Oncogenic state and cell identity combinatorially dictate the susceptibility of cells within glioma development hierarchy to IGF1R targeting","intvolume":"         7","publication_status":"published","date_created":"2020-10-01T09:44:13Z","department":[{"_id":"SiHi"}],"article_processing_charge":"No","file_date_updated":"2020-12-10T14:07:24Z","quality_controlled":"1","ec_funded":1,"article_type":"original","publisher":"Wiley"},{"publication_status":"published","department":[{"_id":"BjHo"}],"date_created":"2020-10-08T17:27:32Z","article_processing_charge":"No","title":"Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits","intvolume":"       125","_id":"8634","author":[{"full_name":"Suri, Balachandra","last_name":"Suri","first_name":"Balachandra","id":"47A5E706-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kageorge, Logan","last_name":"Kageorge","first_name":"Logan"},{"full_name":"Grigoriev, Roman O.","last_name":"Grigoriev","first_name":"Roman O."},{"full_name":"Schatz, Michael F.","last_name":"Schatz","first_name":"Michael F."}],"issue":"6","publisher":"American Physical Society","article_type":"original","ec_funded":1,"quality_controlled":"1","arxiv":1,"doi":"10.1103/physrevlett.125.064501","day":"05","abstract":[{"text":"In laboratory studies and numerical simulations, we observe clear signatures of unstable time-periodic solutions in a moderately turbulent quasi-two-dimensional flow. We validate the dynamical relevance of such solutions by demonstrating that turbulent flows in both experiment and numerics transiently display time-periodic dynamics when they shadow unstable periodic orbits (UPOs). We show that UPOs we computed are also statistically significant, with turbulent flows spending a sizable fraction of the total time near these solutions. As a result, the average rates of energy input and dissipation for the turbulent flow and frequently visited UPOs differ only by a few percent.","lang":"eng"}],"date_updated":"2023-09-05T12:08:29Z","year":"2020","citation":{"ista":"Suri B, Kageorge L, Grigoriev RO, Schatz MF. 2020. Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits. Physical Review Letters. 125(6), 064501.","mla":"Suri, Balachandra, et al. “Capturing Turbulent Dynamics and Statistics in Experiments with Unstable Periodic Orbits.” <i>Physical Review Letters</i>, vol. 125, no. 6, 064501, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/physrevlett.125.064501\">10.1103/physrevlett.125.064501</a>.","short":"B. Suri, L. Kageorge, R.O. Grigoriev, M.F. Schatz, Physical Review Letters 125 (2020).","ieee":"B. Suri, L. Kageorge, R. O. Grigoriev, and M. F. Schatz, “Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits,” <i>Physical Review Letters</i>, vol. 125, no. 6. American Physical Society, 2020.","chicago":"Suri, Balachandra, Logan Kageorge, Roman O. Grigoriev, and Michael F. Schatz. “Capturing Turbulent Dynamics and Statistics in Experiments with Unstable Periodic Orbits.” <i>Physical Review Letters</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/physrevlett.125.064501\">https://doi.org/10.1103/physrevlett.125.064501</a>.","apa":"Suri, B., Kageorge, L., Grigoriev, R. O., &#38; Schatz, M. F. (2020). Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.125.064501\">https://doi.org/10.1103/physrevlett.125.064501</a>","ama":"Suri B, Kageorge L, Grigoriev RO, Schatz MF. Capturing turbulent dynamics and statistics in experiments with unstable periodic orbits. <i>Physical Review Letters</i>. 2020;125(6). doi:<a href=\"https://doi.org/10.1103/physrevlett.125.064501\">10.1103/physrevlett.125.064501</a>"},"isi":1,"external_id":{"isi":["000555785600005"],"arxiv":["2008.02367"]},"acknowledgement":"M. F. S. and R. O. G. acknowledge funding from the National Science Foundation (CMMI-1234436, DMS1125302, CMMI-1725587) and Defense Advanced Research Projects Agency (HR0011-16-2-0033). B. S.has received funding from the People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7/2007–2013/ under REA Grant Agreement No. 291734.","volume":125,"oa_version":"Preprint","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"}],"month":"08","article_number":"064501","publication":"Physical Review Letters","language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy"],"publication_identifier":{"issn":["0031-9007"],"eissn":["1079-7114"]},"oa":1,"date_published":"2020-08-05T00:00:00Z","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2008.02367"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","status":"public"},{"doi":"10.1038/s41467-020-19372-x","day":"04","abstract":[{"lang":"eng","text":"Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate the eye-lens protein γB-crystallin in the ribosomal exit tunnel. Using mass spectrometry, theoretical simulations, dynamic nuclear polarization-enhanced solid-state nuclear magnetic resonance and cryo-electron microscopy, we show that thiol groups of cysteine residues undergo S-glutathionylation and S-nitrosylation and form non-native disulfide bonds. Thus, covalent modification chemistry occurs already prior to nascent chain release as the ribosome exit tunnel provides sufficient space even for disulfide bond formation which can guide protein folding."}],"date_updated":"2023-08-22T12:36:07Z","citation":{"short":"L. Schulte, J. Mao, J. Reitz, S. Sreeramulu, D. Kudlinzki, V.-V. Hodirnau, J. Meier-Credo, K. Saxena, F. Buhr, J.D. Langer, M. Blackledge, A.S. Frangakis, C. Glaubitz, H. Schwalbe, Nature Communications 11 (2020).","mla":"Schulte, Linda, et al. “Cysteine Oxidation and Disulfide Formation in the Ribosomal Exit Tunnel.” <i>Nature Communications</i>, vol. 11, 5569, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-19372-x\">10.1038/s41467-020-19372-x</a>.","ista":"Schulte L, Mao J, Reitz J, Sreeramulu S, Kudlinzki D, Hodirnau V-V, Meier-Credo J, Saxena K, Buhr F, Langer JD, Blackledge M, Frangakis AS, Glaubitz C, Schwalbe H. 2020. Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nature Communications. 11, 5569.","ama":"Schulte L, Mao J, Reitz J, et al. Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-19372-x\">10.1038/s41467-020-19372-x</a>","apa":"Schulte, L., Mao, J., Reitz, J., Sreeramulu, S., Kudlinzki, D., Hodirnau, V.-V., … Schwalbe, H. (2020). Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-19372-x\">https://doi.org/10.1038/s41467-020-19372-x</a>","chicago":"Schulte, Linda, Jiafei Mao, Julian Reitz, Sridhar Sreeramulu, Denis Kudlinzki, Victor-Valentin Hodirnau, Jakob Meier-Credo, et al. “Cysteine Oxidation and Disulfide Formation in the Ribosomal Exit Tunnel.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-19372-x\">https://doi.org/10.1038/s41467-020-19372-x</a>.","ieee":"L. Schulte <i>et al.</i>, “Cysteine oxidation and disulfide formation in the ribosomal exit tunnel,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020."},"year":"2020","isi":1,"external_id":{"isi":["000592028600001"]},"acknowledgement":"We acknowledge help from Anja Seybert, Margot Frangakis, Diana Grewe, Mikhail Eltsov, Utz Ermel, and Shintaro Aibara. The work was supported by Deutsche Forschungsgemeinschaft in the CLiC graduate school. Work at the Center for Biomolecular Magnetic Resonance (BMRZ) is supported by the German state of Hesse. The work at BMRZ has been supported by the state of Hesse. L.S. has been supported by the DFG graduate college: CLiC.","volume":11,"ddc":["570"],"publication_status":"published","department":[{"_id":"EM-Fac"}],"date_created":"2020-11-09T07:49:36Z","article_processing_charge":"No","title":"Cysteine oxidation and disulfide formation in the ribosomal exit tunnel","intvolume":"        11","_id":"8744","scopus_import":"1","author":[{"last_name":"Schulte","first_name":"Linda","full_name":"Schulte, Linda"},{"first_name":"Jiafei","last_name":"Mao","full_name":"Mao, Jiafei"},{"first_name":"Julian","last_name":"Reitz","full_name":"Reitz, Julian"},{"first_name":"Sridhar","last_name":"Sreeramulu","full_name":"Sreeramulu, Sridhar"},{"full_name":"Kudlinzki, Denis","first_name":"Denis","last_name":"Kudlinzki"},{"last_name":"Hodirnau","first_name":"Victor-Valentin","full_name":"Hodirnau, Victor-Valentin","id":"3661B498-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jakob","last_name":"Meier-Credo","full_name":"Meier-Credo, Jakob"},{"first_name":"Krishna","last_name":"Saxena","full_name":"Saxena, Krishna"},{"full_name":"Buhr, Florian","first_name":"Florian","last_name":"Buhr"},{"first_name":"Julian D.","last_name":"Langer","full_name":"Langer, Julian D."},{"first_name":"Martin","last_name":"Blackledge","full_name":"Blackledge, Martin"},{"last_name":"Frangakis","first_name":"Achilleas S.","full_name":"Frangakis, Achilleas S."},{"first_name":"Clemens","last_name":"Glaubitz","full_name":"Glaubitz, Clemens"},{"full_name":"Schwalbe, Harald","first_name":"Harald","last_name":"Schwalbe"}],"publisher":"Springer Nature","article_type":"original","quality_controlled":"1","file_date_updated":"2020-11-09T07:56:24Z","publication_identifier":{"issn":["2041-1723"]},"oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_published":"2020-11-04T00:00:00Z","type":"journal_article","file":[{"checksum":"b2688f0347e69e6629bba582077278c5","file_size":1670898,"date_created":"2020-11-09T07:56:24Z","content_type":"application/pdf","file_name":"2020_NatureComm_Schulte.pdf","date_updated":"2020-11-09T07:56:24Z","success":1,"relation":"main_file","access_level":"open_access","creator":"dernst","file_id":"8745"}],"status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","month":"11","article_number":"5569","publication":"Nature Communications","has_accepted_license":"1","language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"]},{"oa":1,"publication_identifier":{"issn":["2041-1723"]},"date_published":"2020-12-22T00:00:00Z","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/cutting-edge-technology-reveals-structures-within-cells/"}]},"file":[{"file_name":"2020_NatureComm_Faessler.pdf","content_type":"application/pdf","date_updated":"2020-12-28T08:16:10Z","file_size":3958727,"checksum":"55d43ea0061cc4027ba45e966e1db8cc","date_created":"2020-12-28T08:16:10Z","creator":"dernst","file_id":"8975","relation":"main_file","access_level":"open_access","success":1}],"month":"12","article_number":"6437","oa_version":"Published Version","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"project":[{"name":"Structure and isoform diversity of the Arp2/3 complex","grant_number":"P33367","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A"},{"name":"Protein structure and function in filopodia across scales","grant_number":"M02495","_id":"2674F658-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"publication":"Nature Communications","has_accepted_license":"1","language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"abstract":[{"lang":"eng","text":"The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly regulated and involves complex structural rearrangements and actin filament binding, which are yet to be understood. Here, we report a 9.0 Å resolution structure of the actin filament Arp2/3 complex branch junction in cells using cryo-electron tomography and subtomogram averaging. This allows us to generate an accurate model of the active Arp2/3 complex in the branch junction and its interaction with actin filaments. Notably, our model reveals a previously undescribed set of interactions of the Arp2/3 complex with the mother filament, significantly different to the previous branch junction model. Our structure also indicates a central role for the ArpC3 subunit in stabilizing the active conformation."}],"doi":"10.1038/s41467-020-20286-x","day":"22","isi":1,"external_id":{"isi":["000603078000003"]},"date_updated":"2023-08-24T11:01:50Z","citation":{"apa":"Fäßler, F., Dimchev, G. A., Hodirnau, V.-V., Wan, W., &#38; Schur, F. K. (2020). Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-20286-x\">https://doi.org/10.1038/s41467-020-20286-x</a>","ama":"Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-20286-x\">10.1038/s41467-020-20286-x</a>","chicago":"Fäßler, Florian, Georgi A Dimchev, Victor-Valentin Hodirnau, William Wan, and Florian KM Schur. “Cryo-Electron Tomography Structure of Arp2/3 Complex in Cells Reveals New Insights into the Branch Junction.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-20286-x\">https://doi.org/10.1038/s41467-020-20286-x</a>.","ieee":"F. Fäßler, G. A. Dimchev, V.-V. Hodirnau, W. Wan, and F. K. Schur, “Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","short":"F. Fäßler, G.A. Dimchev, V.-V. Hodirnau, W. Wan, F.K. Schur, Nature Communications 11 (2020).","mla":"Fäßler, Florian, et al. “Cryo-Electron Tomography Structure of Arp2/3 Complex in Cells Reveals New Insights into the Branch Junction.” <i>Nature Communications</i>, vol. 11, 6437, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-20286-x\">10.1038/s41467-020-20286-x</a>.","ista":"Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. 2020. Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. Nature Communications. 11, 6437."},"year":"2020","ddc":["570"],"volume":11,"acknowledgement":"This research was supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the BioImaging Facility (BIF), and the Electron Microscopy Facility (EMF). We also thank Dimitry Tegunov (MPI for Biophysical Chemistry) for helpful discussions\r\nabout the M software, and Michael Sixt (IST Austria) and Klemens Rottner (Technical University Braunschweig, HZI Braunschweig) for critical reading of the manuscript. We also thank Gregory Voth (University of Chicago) for providing us the MD-derived branch junction model for comparison. The authors acknowledge support from IST Austria and from the Austrian Science Fund (FWF): M02495 to G.D. and Austrian Science Fund (FWF): P33367 to F.K.M.S. ","title":"Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction","intvolume":"        11","publication_status":"published","department":[{"_id":"FlSc"},{"_id":"EM-Fac"}],"date_created":"2020-12-23T08:25:45Z","article_processing_charge":"No","author":[{"id":"404F5528-F248-11E8-B48F-1D18A9856A87","full_name":"Fäßler, Florian","orcid":"0000-0001-7149-769X","last_name":"Fäßler","first_name":"Florian"},{"first_name":"Georgi A","last_name":"Dimchev","orcid":"0000-0001-8370-6161","full_name":"Dimchev, Georgi A","id":"38C393BE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hodirnau","first_name":"Victor-Valentin","full_name":"Hodirnau, Victor-Valentin","id":"3661B498-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Wan, William","first_name":"William","last_name":"Wan"},{"last_name":"Schur","first_name":"Florian KM","full_name":"Schur, Florian KM","orcid":"0000-0003-4790-8078","id":"48AD8942-F248-11E8-B48F-1D18A9856A87"}],"_id":"8971","scopus_import":"1","article_type":"original","publisher":"Springer Nature","file_date_updated":"2020-12-28T08:16:10Z","quality_controlled":"1"},{"publication":"Nature Physics","month":"07","oa_version":"None","language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy"],"date_published":"2020-07-01T00:00:00Z","type":"journal_article","publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","author":[{"last_name":"Biswas","first_name":"Shubhadeep","full_name":"Biswas, Shubhadeep"},{"last_name":"Förg","first_name":"Benjamin","full_name":"Förg, Benjamin"},{"full_name":"Ortmann, Lisa","first_name":"Lisa","last_name":"Ortmann"},{"first_name":"Johannes","last_name":"Schötz","full_name":"Schötz, Johannes"},{"last_name":"Schweinberger","first_name":"Wolfgang","full_name":"Schweinberger, Wolfgang"},{"last_name":"Zimmermann","first_name":"Tomáš","full_name":"Zimmermann, Tomáš"},{"first_name":"Liangwen","last_name":"Pi","full_name":"Pi, Liangwen"},{"full_name":"Baykusheva, Denitsa Rangelova","last_name":"Baykusheva","first_name":"Denitsa Rangelova","id":"71b4d059-2a03-11ee-914d-dfa3beed6530"},{"first_name":"Hafiz A.","last_name":"Masood","full_name":"Masood, Hafiz A."},{"full_name":"Liontos, Ioannis","first_name":"Ioannis","last_name":"Liontos"},{"full_name":"Kamal, Amgad M.","last_name":"Kamal","first_name":"Amgad M."},{"full_name":"Kling, Nora G.","last_name":"Kling","first_name":"Nora G."},{"full_name":"Alharbi, Abdullah F.","last_name":"Alharbi","first_name":"Abdullah F."},{"full_name":"Alharbi, Meshaal","last_name":"Alharbi","first_name":"Meshaal"},{"full_name":"Azzeer, Abdallah M.","last_name":"Azzeer","first_name":"Abdallah M."},{"first_name":"Gregor","last_name":"Hartmann","full_name":"Hartmann, Gregor"},{"last_name":"Wörner","first_name":"Hans J.","full_name":"Wörner, Hans J."},{"last_name":"Landsman","first_name":"Alexandra S.","full_name":"Landsman, Alexandra S."},{"full_name":"Kling, Matthias F.","last_name":"Kling","first_name":"Matthias F."}],"issue":"7","_id":"13999","scopus_import":"1","title":"Probing molecular environment through photoemission delays","intvolume":"        16","publication_status":"published","date_created":"2023-08-09T13:10:07Z","article_processing_charge":"No","page":"778-783","quality_controlled":"1","article_type":"original","publisher":"Springer Nature","date_updated":"2023-08-22T07:38:04Z","year":"2020","citation":{"short":"S. Biswas, B. Förg, L. Ortmann, J. Schötz, W. Schweinberger, T. Zimmermann, L. Pi, D.R. Baykusheva, H.A. Masood, I. Liontos, A.M. Kamal, N.G. Kling, A.F. Alharbi, M. Alharbi, A.M. Azzeer, G. Hartmann, H.J. Wörner, A.S. Landsman, M.F. Kling, Nature Physics 16 (2020) 778–783.","mla":"Biswas, Shubhadeep, et al. “Probing Molecular Environment through Photoemission Delays.” <i>Nature Physics</i>, vol. 16, no. 7, Springer Nature, 2020, pp. 778–83, doi:<a href=\"https://doi.org/10.1038/s41567-020-0887-8\">10.1038/s41567-020-0887-8</a>.","ista":"Biswas S, Förg B, Ortmann L, Schötz J, Schweinberger W, Zimmermann T, Pi L, Baykusheva DR, Masood HA, Liontos I, Kamal AM, Kling NG, Alharbi AF, Alharbi M, Azzeer AM, Hartmann G, Wörner HJ, Landsman AS, Kling MF. 2020. Probing molecular environment through photoemission delays. Nature Physics. 16(7), 778–783.","ama":"Biswas S, Förg B, Ortmann L, et al. Probing molecular environment through photoemission delays. <i>Nature Physics</i>. 2020;16(7):778-783. doi:<a href=\"https://doi.org/10.1038/s41567-020-0887-8\">10.1038/s41567-020-0887-8</a>","apa":"Biswas, S., Förg, B., Ortmann, L., Schötz, J., Schweinberger, W., Zimmermann, T., … Kling, M. F. (2020). Probing molecular environment through photoemission delays. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-020-0887-8\">https://doi.org/10.1038/s41567-020-0887-8</a>","chicago":"Biswas, Shubhadeep, Benjamin Förg, Lisa Ortmann, Johannes Schötz, Wolfgang Schweinberger, Tomáš Zimmermann, Liangwen Pi, et al. “Probing Molecular Environment through Photoemission Delays.” <i>Nature Physics</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41567-020-0887-8\">https://doi.org/10.1038/s41567-020-0887-8</a>.","ieee":"S. Biswas <i>et al.</i>, “Probing molecular environment through photoemission delays,” <i>Nature Physics</i>, vol. 16, no. 7. Springer Nature, pp. 778–783, 2020."},"abstract":[{"text":"Attosecond chronoscopy has revealed small but measurable delays in photoionization, characterized by the ejection of an electron on absorption of a single photon. Ionization-delay measurements in atomic targets provide a wealth of information about the timing of the photoelectric effect, resonances, electron correlations and transport. However, extending this approach to molecules presents challenges, such as identifying the correct ionization channels and the effect of the anisotropic molecular landscape on the measured delays. Here, we measure ionization delays from ethyl iodide around a giant dipole resonance. By using the theoretical value for the iodine atom as a reference, we disentangle the contribution from the functional ethyl group, which is responsible for the characteristic chemical reactivity of a molecule. We find a substantial additional delay caused by the presence of a functional group, which encodes the effect of the molecular potential on the departing electron. Such information is inaccessible to the conventional approach of measuring photoionization cross-sections. The results establish ionization-delay measurements as a valuable tool in investigating the electronic properties of molecules.","lang":"eng"}],"doi":"10.1038/s41567-020-0887-8","day":"01","extern":"1","volume":16},{"year":"2020","citation":{"chicago":"Speck, Thomas, Julien Tailleur, and Jérémie A Palacci. “Focus on Active Colloids and Nanoparticles.” <i>New Journal of Physics</i>. IOP Publishing, 2020. <a href=\"https://doi.org/10.1088/1367-2630/ab90d9\">https://doi.org/10.1088/1367-2630/ab90d9</a>.","ieee":"T. Speck, J. Tailleur, and J. A. Palacci, “Focus on active colloids and nanoparticles,” <i>New Journal of Physics</i>, vol. 22, no. 6. IOP Publishing, 2020.","ama":"Speck T, Tailleur J, Palacci JA. Focus on active colloids and nanoparticles. <i>New Journal of Physics</i>. 2020;22(6). doi:<a href=\"https://doi.org/10.1088/1367-2630/ab90d9\">10.1088/1367-2630/ab90d9</a>","apa":"Speck, T., Tailleur, J., &#38; Palacci, J. A. (2020). Focus on active colloids and nanoparticles. <i>New Journal of Physics</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1367-2630/ab90d9\">https://doi.org/10.1088/1367-2630/ab90d9</a>","ista":"Speck T, Tailleur J, Palacci JA. 2020. Focus on active colloids and nanoparticles. New Journal of Physics. 22(6), 060201.","mla":"Speck, Thomas, et al. “Focus on Active Colloids and Nanoparticles.” <i>New Journal of Physics</i>, vol. 22, no. 6, 060201, IOP Publishing, 2020, doi:<a href=\"https://doi.org/10.1088/1367-2630/ab90d9\">10.1088/1367-2630/ab90d9</a>.","short":"T. Speck, J. Tailleur, J.A. Palacci, New Journal of Physics 22 (2020)."},"date_updated":"2021-02-18T14:57:39Z","day":"01","doi":"10.1088/1367-2630/ab90d9","volume":22,"ddc":["530"],"extern":"1","scopus_import":"1","_id":"9164","issue":"6","author":[{"full_name":"Speck, Thomas","last_name":"Speck","first_name":"Thomas"},{"full_name":"Tailleur, Julien","last_name":"Tailleur","first_name":"Julien"},{"first_name":"Jérémie A","last_name":"Palacci","orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d"}],"date_created":"2021-02-18T14:17:32Z","article_processing_charge":"No","publication_status":"published","intvolume":"        22","title":"Focus on active colloids and nanoparticles","quality_controlled":"1","file_date_updated":"2021-02-18T14:53:33Z","publisher":"IOP Publishing","article_type":"letter_note","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","date_published":"2020-06-01T00:00:00Z","publication_identifier":{"issn":["1367-2630"]},"oa":1,"file":[{"creator":"cziletti","file_id":"9169","access_level":"open_access","success":1,"relation":"main_file","content_type":"application/pdf","file_name":"2020_NewJournPhys_Speck.pdf","date_updated":"2021-02-18T14:53:33Z","checksum":"02759f3ab228c1a061e747155a20f851","file_size":953338,"date_created":"2021-02-18T14:53:33Z"}],"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","status":"public","has_accepted_license":"1","publication":"New Journal of Physics","oa_version":"Published Version","article_number":"060201","month":"06","keyword":["General Physics and Astronomy"],"language":[{"iso":"eng"}]},{"publication":"Physical Review Letters","month":"01","article_number":"048102","oa_version":"Preprint","language":[{"iso":"eng"}],"keyword":["general physics and astronomy"],"date_published":"2020-01-31T00:00:00Z","type":"journal_article","oa":1,"publication_identifier":{"eissn":["1079-7114"],"issn":["0031-9007"]},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","status":"public","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/553248","open_access":"1"}],"author":[{"full_name":"Paraschiv, Alexandru","first_name":"Alexandru","last_name":"Paraschiv"},{"first_name":"Smitha","last_name":"Hegde","full_name":"Hegde, Smitha"},{"first_name":"Raman","last_name":"Ganti","full_name":"Ganti, Raman"},{"last_name":"Pilizota","first_name":"Teuta","full_name":"Pilizota, Teuta"},{"id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","first_name":"Anđela","last_name":"Šarić"}],"issue":"4","pmid":1,"_id":"10353","scopus_import":"1","title":"Dynamic clustering regulates activity of mechanosensitive membrane channels","intvolume":"       124","publication_status":"published","date_created":"2021-11-26T09:57:01Z","article_processing_charge":"No","quality_controlled":"1","article_type":"original","publisher":"American Physical Society","external_id":{"pmid":["32058787"]},"date_updated":"2021-11-26T11:21:12Z","citation":{"ista":"Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. 2020. Dynamic clustering regulates activity of mechanosensitive membrane channels. Physical Review Letters. 124(4), 048102.","mla":"Paraschiv, Alexandru, et al. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.” <i>Physical Review Letters</i>, vol. 124, no. 4, 048102, American Physical Society, 2020, doi:<a href=\"https://doi.org/10.1103/physrevlett.124.048102\">10.1103/physrevlett.124.048102</a>.","short":"A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, A. Šarić, Physical Review Letters 124 (2020).","chicago":"Paraschiv, Alexandru, Smitha Hegde, Raman Ganti, Teuta Pilizota, and Anđela Šarić. “Dynamic Clustering Regulates Activity of Mechanosensitive Membrane Channels.” <i>Physical Review Letters</i>. American Physical Society, 2020. <a href=\"https://doi.org/10.1103/physrevlett.124.048102\">https://doi.org/10.1103/physrevlett.124.048102</a>.","ieee":"A. Paraschiv, S. Hegde, R. Ganti, T. Pilizota, and A. Šarić, “Dynamic clustering regulates activity of mechanosensitive membrane channels,” <i>Physical Review Letters</i>, vol. 124, no. 4. American Physical Society, 2020.","ama":"Paraschiv A, Hegde S, Ganti R, Pilizota T, Šarić A. Dynamic clustering regulates activity of mechanosensitive membrane channels. <i>Physical Review Letters</i>. 2020;124(4). doi:<a href=\"https://doi.org/10.1103/physrevlett.124.048102\">10.1103/physrevlett.124.048102</a>","apa":"Paraschiv, A., Hegde, S., Ganti, R., Pilizota, T., &#38; Šarić, A. (2020). Dynamic clustering regulates activity of mechanosensitive membrane channels. <i>Physical Review Letters</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevlett.124.048102\">https://doi.org/10.1103/physrevlett.124.048102</a>"},"year":"2020","abstract":[{"lang":"eng","text":"Experiments have suggested that bacterial mechanosensitive channels separate into 2D clusters, the role of which is unclear. By developing a coarse-grained computer model we find that clustering promotes the channel closure, which is highly dependent on the channel concentration and membrane stress. This behaviour yields a tightly regulated gating system, whereby at high tensions channels gate individually, and at lower tensions the channels spontaneously aggregate and inactivate. We implement this positive feedback into the model for cell volume regulation, and find that the channel clustering protects the cell against excessive loss of cytoplasmic content."}],"doi":"10.1103/physrevlett.124.048102","day":"31","extern":"1","acknowledgement":"We thank Samantha Miller, Bert Poolman, and the members of Šarić and Pilizota laboratories for useful discussion. We acknowledge support from the Engineering and Physical Sciences Research Council (A.P. and A.Š.), the UCL Institute for the Physics of Living Systems (A.P. and A.Š.), Darwin Trust of University of Edinburgh (H.S.), Industrial Biotechnology Innovation Centre (H.S. and T.P.), BBSRC Council Crossing Biological Membrane Network (H.S. and T.P.), BBSRC/EPSRC/MRC Synthetic Biology Research Centre (T.P.), and the Royal Society (A.Š.).","volume":124},{"extern":"1","volume":10,"abstract":[{"lang":"eng","text":"Atomic-resolution structure determination is crucial for understanding protein function. Cryo-EM and NMR spectroscopy both provide structural information, but currently cryo-EM does not routinely give access to atomic-level structural data, and, generally, NMR structure determination is restricted to small (<30 kDa) proteins. We introduce an integrated structure determination approach that simultaneously uses NMR and EM data to overcome the limits of each of these methods. The approach enables structure determination of the 468 kDa large dodecameric aminopeptidase TET2 to a precision and accuracy below 1 Å by combining secondary-structure information obtained from near-complete magic-angle-spinning NMR assignments of the 39 kDa-large subunits, distance restraints from backbone amides and ILV methyl groups, and a 4.1 Å resolution EM map. The resulting structure exceeds current standards of NMR and EM structure determination in terms of molecular weight and precision. Importantly, the approach is successful even in cases where only medium-resolution cryo-EM data are available."}],"doi":"10.1038/s41467-019-10490-9","day":"19","external_id":{"pmid":["31217444"]},"date_updated":"2021-01-12T08:19:03Z","year":"2019","citation":{"apa":"Gauto, D. F., Estrozi, L. F., Schwieters, C. D., Effantin, G., Macek, P., Sounier, R., … Boisbouvier, J. (2019). Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-10490-9\">https://doi.org/10.1038/s41467-019-10490-9</a>","ama":"Gauto DF, Estrozi LF, Schwieters CD, et al. Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-10490-9\">10.1038/s41467-019-10490-9</a>","chicago":"Gauto, Diego F., Leandro F. Estrozi, Charles D. Schwieters, Gregory Effantin, Pavel Macek, Remy Sounier, Astrid C. Sivertsen, et al. “Integrated NMR and Cryo-EM Atomic-Resolution Structure Determination of a Half-Megadalton Enzyme Complex.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-10490-9\">https://doi.org/10.1038/s41467-019-10490-9</a>.","ieee":"D. F. Gauto <i>et al.</i>, “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","mla":"Gauto, Diego F., et al. “Integrated NMR and Cryo-EM Atomic-Resolution Structure Determination of a Half-Megadalton Enzyme Complex.” <i>Nature Communications</i>, vol. 10, 2697, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-10490-9\">10.1038/s41467-019-10490-9</a>.","short":"D.F. Gauto, L.F. Estrozi, C.D. Schwieters, G. Effantin, P. Macek, R. Sounier, A.C. Sivertsen, E. Schmidt, R. Kerfah, G. Mas, J.-P. Colletier, P. Güntert, A. Favier, G. Schoehn, P. Schanda, J. Boisbouvier, Nature Communications 10 (2019).","ista":"Gauto DF, Estrozi LF, Schwieters CD, Effantin G, Macek P, Sounier R, Sivertsen AC, Schmidt E, Kerfah R, Mas G, Colletier J-P, Güntert P, Favier A, Schoehn G, Schanda P, Boisbouvier J. 2019. Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. Nature Communications. 10, 2697."},"article_type":"original","publisher":"Springer Nature","quality_controlled":"1","title":"Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex","intvolume":"        10","publication_status":"published","date_created":"2020-09-17T10:28:25Z","article_processing_charge":"No","author":[{"last_name":"Gauto","first_name":"Diego F.","full_name":"Gauto, Diego F."},{"first_name":"Leandro F.","last_name":"Estrozi","full_name":"Estrozi, Leandro F."},{"last_name":"Schwieters","first_name":"Charles D.","full_name":"Schwieters, Charles D."},{"full_name":"Effantin, Gregory","last_name":"Effantin","first_name":"Gregory"},{"last_name":"Macek","first_name":"Pavel","full_name":"Macek, Pavel"},{"full_name":"Sounier, Remy","first_name":"Remy","last_name":"Sounier"},{"last_name":"Sivertsen","first_name":"Astrid C.","full_name":"Sivertsen, Astrid C."},{"full_name":"Schmidt, Elena","last_name":"Schmidt","first_name":"Elena"},{"last_name":"Kerfah","first_name":"Rime","full_name":"Kerfah, Rime"},{"first_name":"Guillaume","last_name":"Mas","full_name":"Mas, Guillaume"},{"full_name":"Colletier, Jacques-Philippe","last_name":"Colletier","first_name":"Jacques-Philippe"},{"full_name":"Güntert, Peter","last_name":"Güntert","first_name":"Peter"},{"last_name":"Favier","first_name":"Adrien","full_name":"Favier, Adrien"},{"last_name":"Schoehn","first_name":"Guy","full_name":"Schoehn, Guy"},{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","last_name":"Schanda","first_name":"Paul"},{"first_name":"Jerome","last_name":"Boisbouvier","full_name":"Boisbouvier, Jerome"}],"pmid":1,"_id":"8405","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-019-10490-9"}],"oa":1,"publication_identifier":{"issn":["2041-1723"]},"date_published":"2019-06-19T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"month":"06","article_number":"2697","oa_version":"Published Version","publication":"Nature Communications"},{"oa":1,"publication_identifier":{"issn":["2041-1723"]},"date_published":"2019-07-29T00:00:00Z","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"status":"public","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","file":[{"date_updated":"2021-02-02T13:47:21Z","file_name":"2019_NatureComm_Ramananarivo.pdf","content_type":"application/pdf","date_created":"2021-02-02T13:47:21Z","file_size":2820337,"checksum":"70c6e5d6fbea0932b0669505ab6633ec","file_id":"9061","creator":"cziletti","relation":"main_file","access_level":"open_access","success":1}],"month":"07","article_number":"3380","oa_version":"Published Version","publication":"Nature Communications","has_accepted_license":"1","language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"abstract":[{"lang":"eng","text":"Molecular motors are essential to the living, generating fluctuations that boost transport and assist assembly. Active colloids, that consume energy to move, hold similar potential for man-made materials controlled by forces generated from within. Yet, their use as a powerhouse in materials science lacks. Here we show a massive acceleration of the annealing of a monolayer of passive beads by moderate addition of self-propelled microparticles. We rationalize our observations with a model of collisions that drive active fluctuations and activate the annealing. The experiment is quantitatively compared with Brownian dynamic simulations that further unveil a dynamical transition in the mechanism of annealing. Active dopants travel uniformly in the system or co-localize at the grain boundaries as a result of the persistence of their motion. Our findings uncover the potential of internal activity to control materials and lay the groundwork for the rise of materials science beyond equilibrium."}],"arxiv":1,"doi":"10.1038/s41467-019-11362-y","day":"29","external_id":{"pmid":["31358762"],"arxiv":["1909.07382"]},"date_updated":"2023-02-23T13:47:59Z","year":"2019","citation":{"ista":"Ramananarivo S, Ducrot E, Palacci JA. 2019. Activity-controlled annealing of colloidal monolayers. Nature Communications. 10(1), 3380.","short":"S. Ramananarivo, E. Ducrot, J.A. Palacci, Nature Communications 10 (2019).","mla":"Ramananarivo, Sophie, et al. “Activity-Controlled Annealing of Colloidal Monolayers.” <i>Nature Communications</i>, vol. 10, no. 1, 3380, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-11362-y\">10.1038/s41467-019-11362-y</a>.","chicago":"Ramananarivo, Sophie, Etienne Ducrot, and Jérémie A Palacci. “Activity-Controlled Annealing of Colloidal Monolayers.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-11362-y\">https://doi.org/10.1038/s41467-019-11362-y</a>.","ieee":"S. Ramananarivo, E. Ducrot, and J. A. Palacci, “Activity-controlled annealing of colloidal monolayers,” <i>Nature Communications</i>, vol. 10, no. 1. Springer Nature, 2019.","apa":"Ramananarivo, S., Ducrot, E., &#38; Palacci, J. A. (2019). Activity-controlled annealing of colloidal monolayers. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-11362-y\">https://doi.org/10.1038/s41467-019-11362-y</a>","ama":"Ramananarivo S, Ducrot E, Palacci JA. Activity-controlled annealing of colloidal monolayers. <i>Nature Communications</i>. 2019;10(1). doi:<a href=\"https://doi.org/10.1038/s41467-019-11362-y\">10.1038/s41467-019-11362-y</a>"},"extern":"1","ddc":["530"],"volume":10,"title":"Activity-controlled annealing of colloidal monolayers","intvolume":"        10","publication_status":"published","article_processing_charge":"No","date_created":"2021-02-02T13:43:36Z","author":[{"first_name":"Sophie","last_name":"Ramananarivo","full_name":"Ramananarivo, Sophie"},{"full_name":"Ducrot, Etienne","first_name":"Etienne","last_name":"Ducrot"},{"first_name":"Jérémie A","last_name":"Palacci","orcid":"0000-0002-7253-9465","full_name":"Palacci, Jérémie A","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d"}],"issue":"1","pmid":1,"_id":"9060","scopus_import":"1","article_type":"original","publisher":"Springer Nature","file_date_updated":"2021-02-02T13:47:21Z","quality_controlled":"1"},{"publication_identifier":{"issn":["1745-2473"],"eissn":["1745-2481"]},"type":"journal_article","date_published":"2019-12-16T00:00:00Z","status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","month":"12","oa_version":"None","publication":"Nature Physics","keyword":["General Physics and Astronomy"],"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Partially filled Landau levels host competing electronic orders. For example, electron solids may prevail close to integer filling of the Landau levels before giving way to fractional quantum Hall liquids at higher carrier density1,2. Here, we report the observation of an electron solid with non-collinear spin texture in monolayer graphene, consistent with solidification of skyrmions3—topological spin textures characterized by quantized electrical charge4,5. We probe the spin texture of the solids using a modified Corbino geometry that allows ferromagnetic magnons to be launched and detected6,7. We find that magnon transport is highly efficient when one Landau level is filled (ν=1), consistent with quantum Hall ferromagnetic spin polarization. However, even minimal doping immediately quenches the magnon signal while leaving the vanishing low-temperature charge conductivity unchanged. Our results can be understood by the formation of a solid of charged skyrmions near ν=1, whose non-collinear spin texture leads to rapid magnon decay. Data near fractional fillings show evidence of several fractional skyrmion solids, suggesting that graphene hosts a highly tunable landscape of coupled spin and charge orders."}],"day":"16","doi":"10.1038/s41567-019-0729-8","citation":{"ama":"Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. Solids of quantum Hall skyrmions in graphene. <i>Nature Physics</i>. 2019;16(2):154-158. doi:<a href=\"https://doi.org/10.1038/s41567-019-0729-8\">10.1038/s41567-019-0729-8</a>","apa":"Zhou, H., Polshyn, H., Taniguchi, T., Watanabe, K., &#38; Young, A. F. (2019). Solids of quantum Hall skyrmions in graphene. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-019-0729-8\">https://doi.org/10.1038/s41567-019-0729-8</a>","ieee":"H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young, “Solids of quantum Hall skyrmions in graphene,” <i>Nature Physics</i>, vol. 16, no. 2. Springer Nature, pp. 154–158, 2019.","chicago":"Zhou, H., Hryhoriy Polshyn, T. Taniguchi, K. Watanabe, and A. F. Young. “Solids of Quantum Hall Skyrmions in Graphene.” <i>Nature Physics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41567-019-0729-8\">https://doi.org/10.1038/s41567-019-0729-8</a>.","mla":"Zhou, H., et al. “Solids of Quantum Hall Skyrmions in Graphene.” <i>Nature Physics</i>, vol. 16, no. 2, Springer Nature, 2019, pp. 154–58, doi:<a href=\"https://doi.org/10.1038/s41567-019-0729-8\">10.1038/s41567-019-0729-8</a>.","short":"H. Zhou, H. Polshyn, T. Taniguchi, K. Watanabe, A.F. Young, Nature Physics 16 (2019) 154–158.","ista":"Zhou H, Polshyn H, Taniguchi T, Watanabe K, Young AF. 2019. Solids of quantum Hall skyrmions in graphene. Nature Physics. 16(2), 154–158."},"year":"2019","date_updated":"2022-01-13T15:34:44Z","extern":"1","acknowledgement":"We acknowledge discussions with B. Halperin, C. Huang, A. Macdonald and M. Zalatel. Experimental work at UCSB was supported by the Army Research Office under awards nos. MURI W911NF-16-1-0361 and W911NF-16-1-0482. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by MEXT (Japan) and CREST (JPMJCR15F3), JST. A.F.Y. acknowledges the support of the David and Lucile Packard Foundation and and Alfred. P. Sloan Foundation.","volume":16,"intvolume":"        16","title":"Solids of quantum Hall skyrmions in graphene","date_created":"2022-01-13T14:45:16Z","article_processing_charge":"No","publication_status":"published","issue":"2","author":[{"last_name":"Zhou","first_name":"H.","full_name":"Zhou, H."},{"id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","full_name":"Polshyn, Hryhoriy","orcid":"0000-0001-8223-8896","last_name":"Polshyn","first_name":"Hryhoriy"},{"first_name":"T.","last_name":"Taniguchi","full_name":"Taniguchi, T."},{"full_name":"Watanabe, K.","first_name":"K.","last_name":"Watanabe"},{"full_name":"Young, A. F.","first_name":"A. F.","last_name":"Young"}],"scopus_import":"1","_id":"10620","article_type":"original","publisher":"Springer Nature","quality_controlled":"1","page":"154-158"},{"oa_version":"Preprint","month":"08","publication":"Nature Physics","keyword":["general physics and astronomy"],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1745-2481"],"issn":["1745-2473"]},"oa":1,"type":"journal_article","date_published":"2019-08-05T00:00:00Z","main_file_link":[{"url":"https://arxiv.org/abs/1902.00763","open_access":"1"}],"status":"public","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","date_created":"2022-01-13T15:00:58Z","publication_status":"published","intvolume":"        15","title":"Large linear-in-temperature resistivity in twisted bilayer graphene","scopus_import":"1","_id":"10621","issue":"10","author":[{"orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy","first_name":"Hryhoriy","last_name":"Polshyn","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48"},{"full_name":"Yankowitz, Matthew","first_name":"Matthew","last_name":"Yankowitz"},{"last_name":"Chen","first_name":"Shaowen","full_name":"Chen, Shaowen"},{"first_name":"Yuxuan","last_name":"Zhang","full_name":"Zhang, Yuxuan"},{"first_name":"K.","last_name":"Watanabe","full_name":"Watanabe, K."},{"full_name":"Taniguchi, T.","last_name":"Taniguchi","first_name":"T."},{"first_name":"Cory R.","last_name":"Dean","full_name":"Dean, Cory R."},{"full_name":"Young, Andrea F.","last_name":"Young","first_name":"Andrea F."}],"publisher":"Springer Nature","article_type":"original","quality_controlled":"1","page":"1011-1016","day":"05","doi":"10.1038/s41567-019-0596-3","arxiv":1,"abstract":[{"lang":"eng","text":"Twisted bilayer graphene has recently emerged as a platform for hosting correlated phenomena. For twist angles near θ ≈ 1.1°, the low-energy electronic structure of twisted bilayer graphene features isolated bands with a flat dispersion1,2. Recent experiments have observed a variety of low-temperature phases that appear to be driven by electron interactions, including insulating states, superconductivity and magnetism3,4,5,6. Here we report electrical transport measurements up to room temperature for twist angles varying between 0.75° and 2°. We find that the resistivity, ρ, scales linearly with temperature, T, over a wide range of T before falling again owing to interband activation. The T-linear response is much larger than observed in monolayer graphene for all measured devices, and in particular increases by more than three orders of magnitude in the range where the flat band exists. Our results point to the dominant role of electron–phonon scattering in twisted bilayer graphene, with possible implications for the origin of the observed superconductivity."}],"citation":{"ieee":"H. Polshyn <i>et al.</i>, “Large linear-in-temperature resistivity in twisted bilayer graphene,” <i>Nature Physics</i>, vol. 15, no. 10. Springer Nature, pp. 1011–1016, 2019.","chicago":"Polshyn, Hryhoriy, Matthew Yankowitz, Shaowen Chen, Yuxuan Zhang, K. Watanabe, T. Taniguchi, Cory R. Dean, and Andrea F. Young. “Large Linear-in-Temperature Resistivity in Twisted Bilayer Graphene.” <i>Nature Physics</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41567-019-0596-3\">https://doi.org/10.1038/s41567-019-0596-3</a>.","ama":"Polshyn H, Yankowitz M, Chen S, et al. Large linear-in-temperature resistivity in twisted bilayer graphene. <i>Nature Physics</i>. 2019;15(10):1011-1016. doi:<a href=\"https://doi.org/10.1038/s41567-019-0596-3\">10.1038/s41567-019-0596-3</a>","apa":"Polshyn, H., Yankowitz, M., Chen, S., Zhang, Y., Watanabe, K., Taniguchi, T., … Young, A. F. (2019). Large linear-in-temperature resistivity in twisted bilayer graphene. <i>Nature Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41567-019-0596-3\">https://doi.org/10.1038/s41567-019-0596-3</a>","ista":"Polshyn H, Yankowitz M, Chen S, Zhang Y, Watanabe K, Taniguchi T, Dean CR, Young AF. 2019. Large linear-in-temperature resistivity in twisted bilayer graphene. Nature Physics. 15(10), 1011–1016.","short":"H. Polshyn, M. Yankowitz, S. Chen, Y. Zhang, K. Watanabe, T. Taniguchi, C.R. Dean, A.F. Young, Nature Physics 15 (2019) 1011–1016.","mla":"Polshyn, Hryhoriy, et al. “Large Linear-in-Temperature Resistivity in Twisted Bilayer Graphene.” <i>Nature Physics</i>, vol. 15, no. 10, Springer Nature, 2019, pp. 1011–16, doi:<a href=\"https://doi.org/10.1038/s41567-019-0596-3\">10.1038/s41567-019-0596-3</a>."},"year":"2019","date_updated":"2022-01-20T09:33:38Z","external_id":{"arxiv":["1902.00763"]},"volume":15,"acknowledgement":"The authors thank S. Das Sarma and F. Wu for sharing their unpublished theoretical results, and acknowledge further discussions with L. Balents and T. Senthil. Work at both Columbia and UCSB was funded by the Army Research Office under award W911NF-17-1-0323. Sample device design and fabrication was partially supported by DoE Pro-QM EFRC (DE-SC0019443). A.F.Y. and C.R.D. separately acknowledge the support of the David and Lucile Packard Foundation. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan and the CREST (JPMJCR15F3), JST. A portion of this work was carried out at the KITP, Santa Barbara, supported by the National Science Foundation under grant number NSF PHY-1748958.","extern":"1"},{"publisher":"The Royal Society","article_type":"original","quality_controlled":"1","language":[{"iso":"eng"}],"keyword":["General Engineering","General Physics and Astronomy","General Mathematics"],"publication_status":"published","oa_version":"None","date_created":"2020-09-17T10:42:01Z","article_processing_charge":"No","month":"10","title":"On the integrability of Birkhoff billiards","intvolume":"       376","article_number":"20170419","publication":"Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences","_id":"8419","author":[{"id":"FE553552-CDE8-11E9-B324-C0EBE5697425","last_name":"Kaloshin","first_name":"Vadim","full_name":"Kaloshin, Vadim","orcid":"0000-0002-6051-2628"},{"full_name":"Sorrentino, Alfonso","first_name":"Alfonso","last_name":"Sorrentino"}],"issue":"2131","volume":376,"extern":"1","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","doi":"10.1098/rsta.2017.0419","publication_identifier":{"issn":["1364-503X","1471-2962"]},"day":"28","abstract":[{"text":"In this survey, we provide a concise introduction to convex billiards and describe some recent results, obtained by the authors and collaborators, on the classification of integrable billiards, namely the so-called Birkhoff conjecture.\r\n\r\nThis article is part of the theme issue ‘Finite dimensional integrable systems: new trends and methods’.","lang":"eng"}],"date_updated":"2021-01-12T08:19:09Z","year":"2018","citation":{"ieee":"V. Kaloshin and A. Sorrentino, “On the integrability of Birkhoff billiards,” <i>Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences</i>, vol. 376, no. 2131. The Royal Society, 2018.","chicago":"Kaloshin, Vadim, and Alfonso Sorrentino. “On the Integrability of Birkhoff Billiards.” <i>Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences</i>. The Royal Society, 2018. <a href=\"https://doi.org/10.1098/rsta.2017.0419\">https://doi.org/10.1098/rsta.2017.0419</a>.","apa":"Kaloshin, V., &#38; Sorrentino, A. (2018). On the integrability of Birkhoff billiards. <i>Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences</i>. The Royal Society. <a href=\"https://doi.org/10.1098/rsta.2017.0419\">https://doi.org/10.1098/rsta.2017.0419</a>","ama":"Kaloshin V, Sorrentino A. On the integrability of Birkhoff billiards. <i>Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences</i>. 2018;376(2131). doi:<a href=\"https://doi.org/10.1098/rsta.2017.0419\">10.1098/rsta.2017.0419</a>","ista":"Kaloshin V, Sorrentino A. 2018. On the integrability of Birkhoff billiards. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences. 376(2131), 20170419.","short":"V. Kaloshin, A. Sorrentino, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 376 (2018).","mla":"Kaloshin, Vadim, and Alfonso Sorrentino. “On the Integrability of Birkhoff Billiards.” <i>Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences</i>, vol. 376, no. 2131, 20170419, The Royal Society, 2018, doi:<a href=\"https://doi.org/10.1098/rsta.2017.0419\">10.1098/rsta.2017.0419</a>."},"date_published":"2018-10-28T00:00:00Z","type":"journal_article"},{"page":"5214-5234","quality_controlled":"1","article_type":"original","publisher":"IOP Publishing","author":[{"id":"FE553552-CDE8-11E9-B324-C0EBE5697425","full_name":"Kaloshin, Vadim","orcid":"0000-0002-6051-2628","last_name":"Kaloshin","first_name":"Vadim"},{"full_name":"Zhang, Ke","last_name":"Zhang","first_name":"Ke"}],"issue":"11","_id":"8420","title":"Density of convex billiards with rational caustics","intvolume":"        31","publication_status":"published","article_processing_charge":"No","date_created":"2020-09-17T10:42:09Z","extern":"1","volume":31,"external_id":{"arxiv":["1706.07968"]},"date_updated":"2021-01-12T08:19:10Z","year":"2018","citation":{"mla":"Kaloshin, Vadim, and Ke Zhang. “Density of Convex Billiards with Rational Caustics.” <i>Nonlinearity</i>, vol. 31, no. 11, IOP Publishing, 2018, pp. 5214–34, doi:<a href=\"https://doi.org/10.1088/1361-6544/aadc12\">10.1088/1361-6544/aadc12</a>.","short":"V. Kaloshin, K. Zhang, Nonlinearity 31 (2018) 5214–5234.","ista":"Kaloshin V, Zhang K. 2018. Density of convex billiards with rational caustics. Nonlinearity. 31(11), 5214–5234.","apa":"Kaloshin, V., &#38; Zhang, K. (2018). Density of convex billiards with rational caustics. <i>Nonlinearity</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/1361-6544/aadc12\">https://doi.org/10.1088/1361-6544/aadc12</a>","ama":"Kaloshin V, Zhang K. Density of convex billiards with rational caustics. <i>Nonlinearity</i>. 2018;31(11):5214-5234. doi:<a href=\"https://doi.org/10.1088/1361-6544/aadc12\">10.1088/1361-6544/aadc12</a>","ieee":"V. Kaloshin and K. Zhang, “Density of convex billiards with rational caustics,” <i>Nonlinearity</i>, vol. 31, no. 11. IOP Publishing, pp. 5214–5234, 2018.","chicago":"Kaloshin, Vadim, and Ke Zhang. “Density of Convex Billiards with Rational Caustics.” <i>Nonlinearity</i>. IOP Publishing, 2018. <a href=\"https://doi.org/10.1088/1361-6544/aadc12\">https://doi.org/10.1088/1361-6544/aadc12</a>."},"abstract":[{"text":"We show that in the space of all convex billiard boundaries, the set of boundaries with rational caustics is dense. More precisely, the set of billiard boundaries with caustics of rotation number 1/q is polynomially sense in the smooth case, and exponentially dense in the analytic case.","lang":"eng"}],"doi":"10.1088/1361-6544/aadc12","arxiv":1,"day":"15","language":[{"iso":"eng"}],"keyword":["Mathematical Physics","General Physics and Astronomy","Applied Mathematics","Statistical and Nonlinear Physics"],"publication":"Nonlinearity","month":"10","oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","main_file_link":[{"url":"https://arxiv.org/abs/1706.07968","open_access":"1"}],"date_published":"2018-10-15T00:00:00Z","type":"journal_article","oa":1,"publication_identifier":{"issn":["0951-7715","1361-6544"]}},{"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"month":"02","article_number":"641","oa_version":"Published Version","publication":"Nature Communications","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"link":[{"url":"https://doi.org/10.1038/s41467-018-03701-2","relation":"erratum"}]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-017-02715-6"}],"oa":1,"publication_identifier":{"eissn":["2041-1723"]},"date_published":"2018-02-13T00:00:00Z","type":"journal_article","article_type":"original","publisher":"Springer Nature","quality_controlled":"1","title":"Reversible chromism of spiropyran in the cavity of a flexible coordination cage","intvolume":"         9","publication_status":"published","date_created":"2023-08-01T09:39:32Z","article_processing_charge":"No","author":[{"full_name":"Samanta, Dipak","last_name":"Samanta","first_name":"Dipak"},{"first_name":"Daria","last_name":"Galaktionova","full_name":"Galaktionova, Daria"},{"full_name":"Gemen, Julius","last_name":"Gemen","first_name":"Julius"},{"full_name":"Shimon, Linda J. W.","first_name":"Linda J. W.","last_name":"Shimon"},{"full_name":"Diskin-Posner, Yael","first_name":"Yael","last_name":"Diskin-Posner"},{"first_name":"Liat","last_name":"Avram","full_name":"Avram, Liat"},{"first_name":"Petr","last_name":"Král","full_name":"Král, Petr"},{"last_name":"Klajn","first_name":"Rafal","full_name":"Klajn, Rafal","id":"8e84690e-1e48-11ed-a02b-a1e6fb8bb53b"}],"pmid":1,"_id":"13374","scopus_import":"1","extern":"1","volume":9,"abstract":[{"text":"Confining molecules to volumes only slightly larger than the molecules themselves can profoundly alter their properties. Molecular switches—entities that can be toggled between two or more forms upon exposure to an external stimulus—often require conformational freedom to isomerize. Therefore, placing these switches in confined spaces can render them non-operational. To preserve the switchability of these species under confinement, we work with a water-soluble coordination cage that is flexible enough to adapt its shape to the conformation of the encapsulated guest. We show that owing to its flexibility, the cage is not only capable of accommodating—and solubilizing in water—several light-responsive spiropyran-based molecular switches, but, more importantly, it also provides an environment suitable for the efficient, reversible photoisomerization of the bound guests. Our findings pave the way towards studying various molecular switching processes in confined environments.","lang":"eng"}],"doi":"10.1038/s41467-017-02715-6","day":"13","external_id":{"pmid":["29440687"]},"date_updated":"2023-08-07T10:54:05Z","citation":{"chicago":"Samanta, Dipak, Daria Galaktionova, Julius Gemen, Linda J. W. Shimon, Yael Diskin-Posner, Liat Avram, Petr Král, and Rafal Klajn. “Reversible Chromism of Spiropyran in the Cavity of a Flexible Coordination Cage.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-017-02715-6\">https://doi.org/10.1038/s41467-017-02715-6</a>.","ieee":"D. Samanta <i>et al.</i>, “Reversible chromism of spiropyran in the cavity of a flexible coordination cage,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","apa":"Samanta, D., Galaktionova, D., Gemen, J., Shimon, L. J. W., Diskin-Posner, Y., Avram, L., … Klajn, R. (2018). Reversible chromism of spiropyran in the cavity of a flexible coordination cage. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-017-02715-6\">https://doi.org/10.1038/s41467-017-02715-6</a>","ama":"Samanta D, Galaktionova D, Gemen J, et al. Reversible chromism of spiropyran in the cavity of a flexible coordination cage. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-017-02715-6\">10.1038/s41467-017-02715-6</a>","ista":"Samanta D, Galaktionova D, Gemen J, Shimon LJW, Diskin-Posner Y, Avram L, Král P, Klajn R. 2018. Reversible chromism of spiropyran in the cavity of a flexible coordination cage. Nature Communications. 9, 641.","short":"D. Samanta, D. Galaktionova, J. Gemen, L.J.W. Shimon, Y. Diskin-Posner, L. Avram, P. Král, R. Klajn, Nature Communications 9 (2018).","mla":"Samanta, Dipak, et al. “Reversible Chromism of Spiropyran in the Cavity of a Flexible Coordination Cage.” <i>Nature Communications</i>, vol. 9, 641, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-017-02715-6\">10.1038/s41467-017-02715-6</a>."},"year":"2018"},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1103/PhysRevX.8.031060"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2018-07-01T00:00:00Z","type":"journal_article","publication_identifier":{"eissn":["2160-3308"]},"oa":1,"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy"],"publication":"Physical Review X","oa_version":"Published Version","month":"07","article_number":"031060","volume":8,"extern":"1","date_updated":"2023-08-22T07:42:07Z","citation":{"short":"D.R. Baykusheva, H.J. Wörner, Physical Review X 8 (2018).","mla":"Baykusheva, Denitsa Rangelova, and Hans Jakob Wörner. “Chiral Discrimination through Bielliptical High-Harmonic Spectroscopy.” <i>Physical Review X</i>, vol. 8, no. 3, 031060, American Physical Society, 2018, doi:<a href=\"https://doi.org/10.1103/physrevx.8.031060\">10.1103/physrevx.8.031060</a>.","ista":"Baykusheva DR, Wörner HJ. 2018. Chiral discrimination through bielliptical high-harmonic spectroscopy. Physical Review X. 8(3), 031060.","apa":"Baykusheva, D. R., &#38; Wörner, H. J. (2018). Chiral discrimination through bielliptical high-harmonic spectroscopy. <i>Physical Review X</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevx.8.031060\">https://doi.org/10.1103/physrevx.8.031060</a>","ama":"Baykusheva DR, Wörner HJ. Chiral discrimination through bielliptical high-harmonic spectroscopy. <i>Physical Review X</i>. 2018;8(3). doi:<a href=\"https://doi.org/10.1103/physrevx.8.031060\">10.1103/physrevx.8.031060</a>","chicago":"Baykusheva, Denitsa Rangelova, and Hans Jakob Wörner. “Chiral Discrimination through Bielliptical High-Harmonic Spectroscopy.” <i>Physical Review X</i>. American Physical Society, 2018. <a href=\"https://doi.org/10.1103/physrevx.8.031060\">https://doi.org/10.1103/physrevx.8.031060</a>.","ieee":"D. R. Baykusheva and H. J. Wörner, “Chiral discrimination through bielliptical high-harmonic spectroscopy,” <i>Physical Review X</i>, vol. 8, no. 3. American Physical Society, 2018."},"year":"2018","doi":"10.1103/physrevx.8.031060","day":"01","abstract":[{"lang":"eng","text":"Molecular chirality plays an essential role in most biochemical processes. The observation and quantification of chirality-sensitive signals, however, remains extremely challenging, especially on ultrafast timescales and in dilute media. Here, we describe the experimental realization of an all-optical and ultrafast scheme for detecting chiral dynamics in molecules. This technique is based on high-harmonic generation by a combination of two-color counterrotating femtosecond laser pulses with polarization states tunable from linear to circular. We demonstrate two different implementations of chiral-sensitive high-harmonic spectroscopy on an ensemble of randomly oriented methyloxirane molecules in the gas phase. Using two elliptically polarized fields, we observe that the ellipticities maximizing the harmonic signal reach up to \r\n4.4\r\n±\r\n0.2\r\n%\r\n (at 17.6 eV). Using two circularly polarized fields, we observe circular dichroisms ranging up to \r\n13\r\n±\r\n6\r\n%\r\n (28.3–33.1 eV). Our theoretical analysis confirms that the observed chiral response originates from subfemtosecond electron dynamics driven by the magnetic component of the driving laser field. This assignment is supported by the experimental observation of a strong intensity dependence of the chiral effects and its agreement with theory. We moreover report and explain a pronounced variation of the signal strength and dichroism with the driving-field ellipticities and harmonic orders. Finally, we demonstrate the sensitivity of the experimental observables to the shape of the electron hole. This technique for chiral discrimination will yield femtosecond temporal resolution when integrated in a pump-probe scheme and subfemtosecond resolution on chiral charge migration in a self-probing scheme."}],"quality_controlled":"1","publisher":"American Physical Society","article_type":"original","_id":"14003","scopus_import":"1","author":[{"first_name":"Denitsa Rangelova","last_name":"Baykusheva","full_name":"Baykusheva, Denitsa Rangelova","id":"71b4d059-2a03-11ee-914d-dfa3beed6530"},{"full_name":"Wörner, Hans Jakob","first_name":"Hans Jakob","last_name":"Wörner"}],"issue":"3","publication_status":"published","date_created":"2023-08-10T06:34:48Z","article_processing_charge":"No","title":"Chiral discrimination through bielliptical high-harmonic spectroscopy","intvolume":"         8"},{"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"language":[{"iso":"eng"}],"publication":"Nature Communications","article_number":"1806","month":"05","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","main_file_link":[{"url":"https://doi.org/10.1038/s41467-018-04139-2","open_access":"1"}],"type":"journal_article","date_published":"2018-05-04T00:00:00Z","oa":1,"publication_identifier":{"issn":["2041-1723"]},"quality_controlled":"1","article_type":"original","publisher":"Springer Nature","author":[{"full_name":"Bräuning, Bastian","last_name":"Bräuning","first_name":"Bastian"},{"first_name":"Eva","last_name":"Bertosin","full_name":"Bertosin, Eva"},{"last_name":"Praetorius","first_name":"Florian M","full_name":"Praetorius, Florian M","id":"dfec9381-4341-11ee-8fd8-faa02bba7d62"},{"full_name":"Ihling, Christian","first_name":"Christian","last_name":"Ihling"},{"full_name":"Schatt, Alexandra","last_name":"Schatt","first_name":"Alexandra"},{"last_name":"Adler","first_name":"Agnes","full_name":"Adler, Agnes"},{"last_name":"Richter","first_name":"Klaus","full_name":"Richter, Klaus"},{"full_name":"Sinz, Andrea","first_name":"Andrea","last_name":"Sinz"},{"full_name":"Dietz, Hendrik","first_name":"Hendrik","last_name":"Dietz"},{"full_name":"Groll, Michael","first_name":"Michael","last_name":"Groll"}],"scopus_import":"1","pmid":1,"_id":"14284","intvolume":"         9","title":"Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB","article_processing_charge":"No","date_created":"2023-09-06T12:07:33Z","publication_status":"published","extern":"1","volume":9,"external_id":{"pmid":["29728606"]},"year":"2018","citation":{"ista":"Bräuning B, Bertosin E, Praetorius FM, Ihling C, Schatt A, Adler A, Richter K, Sinz A, Dietz H, Groll M. 2018. Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB. Nature Communications. 9, 1806.","short":"B. Bräuning, E. Bertosin, F.M. Praetorius, C. Ihling, A. Schatt, A. Adler, K. Richter, A. Sinz, H. Dietz, M. Groll, Nature Communications 9 (2018).","mla":"Bräuning, Bastian, et al. “Structure and Mechanism of the Two-Component α-Helical Pore-Forming Toxin YaxAB.” <i>Nature Communications</i>, vol. 9, 1806, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-04139-2\">10.1038/s41467-018-04139-2</a>.","chicago":"Bräuning, Bastian, Eva Bertosin, Florian M Praetorius, Christian Ihling, Alexandra Schatt, Agnes Adler, Klaus Richter, Andrea Sinz, Hendrik Dietz, and Michael Groll. “Structure and Mechanism of the Two-Component α-Helical Pore-Forming Toxin YaxAB.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-04139-2\">https://doi.org/10.1038/s41467-018-04139-2</a>.","ieee":"B. Bräuning <i>et al.</i>, “Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","apa":"Bräuning, B., Bertosin, E., Praetorius, F. M., Ihling, C., Schatt, A., Adler, A., … Groll, M. (2018). Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-04139-2\">https://doi.org/10.1038/s41467-018-04139-2</a>","ama":"Bräuning B, Bertosin E, Praetorius FM, et al. Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-018-04139-2\">10.1038/s41467-018-04139-2</a>"},"date_updated":"2023-11-07T11:46:12Z","abstract":[{"lang":"eng","text":"Pore-forming toxins (PFT) are virulence factors that transform from soluble to membrane-bound states. The Yersinia YaxAB system represents a family of binary α-PFTs with orthologues in human, insect, and plant pathogens, with unknown structures. YaxAB was shown to be cytotoxic and likely involved in pathogenesis, though the molecular basis for its two-component lytic mechanism remains elusive. Here, we present crystal structures of YaxA and YaxB, together with a cryo-electron microscopy map of the YaxAB complex. Our structures reveal a pore predominantly composed of decamers of YaxA–YaxB heterodimers. Both subunits bear membrane-active moieties, but only YaxA is capable of binding to membranes by itself. YaxB can subsequently be recruited to membrane-associated YaxA and induced to present its lytic transmembrane helices. Pore formation can progress by further oligomerization of YaxA–YaxB dimers. Our results allow for a comparison between pore assemblies belonging to the wider ClyA-like family of α-PFTs, highlighting diverse pore architectures."}],"day":"04","doi":"10.1038/s41467-018-04139-2"}]