---
_id: '8653'
abstract:
- lang: eng
  text: "Mutations are the raw material of evolution and come in many different flavors.
    Point mutations change a single letter in the DNA sequence, while copy number
    mutations like duplications or deletions add or remove many letters of the DNA
    sequence simultaneously.  Each type of mutation exhibits specific properties like
    its rate of formation and reversal. \r\nGene expression is a fundamental phenotype
    that can be altered by both, point and copy number mutations. The following thesis
    is concerned with the dynamics of gene expression evolution and how it is affected
    by the properties exhibited by point and copy number mutations. Specifically,
    we are considering i) copy number mutations during adaptation to fluctuating environments
    and ii) the interaction of copy number and point mutations during adaptation to
    constant environments.  "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Isabella
  full_name: Tomanek, Isabella
  id: 3981F020-F248-11E8-B48F-1D18A9856A87
  last_name: Tomanek
  orcid: 0000-0001-6197-363X
citation:
  ama: Tomanek I. The evolution of gene expression by copy number and point mutations.
    2020. doi:<a href="https://doi.org/10.15479/AT:ISTA:8653">10.15479/AT:ISTA:8653</a>
  apa: Tomanek, I. (2020). <i>The evolution of gene expression by copy number and
    point mutations</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT:ISTA:8653">https://doi.org/10.15479/AT:ISTA:8653</a>
  chicago: Tomanek, Isabella. “The Evolution of Gene Expression by Copy Number and
    Point Mutations.” Institute of Science and Technology Austria, 2020. <a href="https://doi.org/10.15479/AT:ISTA:8653">https://doi.org/10.15479/AT:ISTA:8653</a>.
  ieee: I. Tomanek, “The evolution of gene expression by copy number and point mutations,”
    Institute of Science and Technology Austria, 2020.
  ista: Tomanek I. 2020. The evolution of gene expression by copy number and point
    mutations. Institute of Science and Technology Austria.
  mla: Tomanek, Isabella. <i>The Evolution of Gene Expression by Copy Number and Point
    Mutations</i>. Institute of Science and Technology Austria, 2020, doi:<a href="https://doi.org/10.15479/AT:ISTA:8653">10.15479/AT:ISTA:8653</a>.
  short: I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations,
    Institute of Science and Technology Austria, 2020.
date_created: 2020-10-13T13:02:33Z
date_published: 2020-10-13T00:00:00Z
date_updated: 2023-09-07T13:22:42Z
day: '13'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:8653
file:
- access_level: closed
  checksum: c01d9f59794b4b70528f37637c17ad02
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  creator: itomanek
  date_created: 2020-10-16T12:14:21Z
  date_updated: 2021-10-20T22:30:03Z
  embargo_to: open_access
  file_id: '8666'
  file_name: Thesis_ITomanek_final_201016.docx
  file_size: 25131884
  relation: source_file
- access_level: open_access
  checksum: f8edbc3b0f81a780e13ca1e561d42d8b
  content_type: application/pdf
  creator: itomanek
  date_created: 2020-10-16T12:14:21Z
  date_updated: 2021-10-20T22:30:03Z
  embargo: 2021-10-19
  file_id: '8667'
  file_name: Thesis_ITomanek_final_201016.pdf
  file_size: 15405675
  relation: main_file
file_date_updated: 2021-10-20T22:30:03Z
has_accepted_license: '1'
keyword:
- duplication
- amplification
- promoter
- CNV
- AMGET
- experimental evolution
- Escherichia coli
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: '117'
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '7652'
    relation: research_data
    status: public
status: public
supervisor:
- first_name: Calin C
  full_name: Guet, Calin C
  id: 47F8433E-F248-11E8-B48F-1D18A9856A87
  last_name: Guet
  orcid: 0000-0001-6220-2052
title: The evolution of gene expression by copy number and point mutations
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2020'
...