---
_id: '9999'
abstract:
- lang: eng
  text: 'The developmental strategies used by progenitor cells to endure a safe journey
    from their induction place towards the site of terminal differentiation are still
    poorly understood. Here we uncovered a progenitor cell allocation mechanism that
    stems from an incomplete process of epithelial delamination that allows progenitors
    to coordinate their movement with adjacent extra-embryonic tissues. Progenitors
    of the zebrafish laterality organ originate from the surface epithelial enveloping
    layer by an apical constriction process of cell delamination. During this process,
    progenitors retain long-term apical contacts that enable the epithelial layer
    to pull a subset of progenitors along their way towards the vegetal pole. The
    remaining delaminated progenitors follow apically-attached progenitors’ movement
    by a co-attraction mechanism, avoiding sequestration by the adjacent endoderm,
    ensuring their fate and collective allocation at the differentiation site. Thus,
    we reveal that incomplete delamination serves as a cellular platform for coordinated
    tissue movements during development. Impact Statement: Incomplete delamination
    serves as a cellular platform for coordinated tissue movements during development,
    guiding newly formed progenitor cell groups to the differentiation site.'
article_number: e66483
article_processing_charge: Yes
article_type: original
author:
- first_name: Eduardo
  full_name: Pulgar, Eduardo
  last_name: Pulgar
- first_name: Cornelia
  full_name: Schwayer, Cornelia
  id: 3436488C-F248-11E8-B48F-1D18A9856A87
  last_name: Schwayer
  orcid: 0000-0001-5130-2226
- first_name: Néstor
  full_name: Guerrero, Néstor
  last_name: Guerrero
- first_name: Loreto
  full_name: López, Loreto
  last_name: López
- first_name: Susana
  full_name: Márquez, Susana
  last_name: Márquez
- first_name: Steffen
  full_name: Härtel, Steffen
  last_name: Härtel
- first_name: Rodrigo
  full_name: Soto, Rodrigo
  last_name: Soto
- first_name: Carl Philipp
  full_name: Heisenberg, Carl Philipp
  last_name: Heisenberg
- first_name: Miguel L.
  full_name: Concha, Miguel L.
  last_name: Concha
citation:
  ama: Pulgar E, Schwayer C, Guerrero N, et al. Apical contacts stemming from incomplete
    delamination guide progenitor cell allocation through a dragging mechanism. <i>eLife</i>.
    2021;10. doi:<a href="https://doi.org/10.7554/eLife.66483">10.7554/eLife.66483</a>
  apa: Pulgar, E., Schwayer, C., Guerrero, N., López, L., Márquez, S., Härtel, S.,
    … Concha, M. L. (2021). Apical contacts stemming from incomplete delamination
    guide progenitor cell allocation through a dragging mechanism. <i>ELife</i>. eLife
    Sciences Publications. <a href="https://doi.org/10.7554/eLife.66483">https://doi.org/10.7554/eLife.66483</a>
  chicago: Pulgar, Eduardo, Cornelia Schwayer, Néstor Guerrero, Loreto López, Susana
    Márquez, Steffen Härtel, Rodrigo Soto, Carl Philipp Heisenberg, and Miguel L.
    Concha. “Apical Contacts Stemming from Incomplete Delamination Guide Progenitor
    Cell Allocation through a Dragging Mechanism.” <i>ELife</i>. eLife Sciences Publications,
    2021. <a href="https://doi.org/10.7554/eLife.66483">https://doi.org/10.7554/eLife.66483</a>.
  ieee: E. Pulgar <i>et al.</i>, “Apical contacts stemming from incomplete delamination
    guide progenitor cell allocation through a dragging mechanism,” <i>eLife</i>,
    vol. 10. eLife Sciences Publications, 2021.
  ista: Pulgar E, Schwayer C, Guerrero N, López L, Márquez S, Härtel S, Soto R, Heisenberg
    CP, Concha ML. 2021. Apical contacts stemming from incomplete delamination guide
    progenitor cell allocation through a dragging mechanism. eLife. 10, e66483.
  mla: Pulgar, Eduardo, et al. “Apical Contacts Stemming from Incomplete Delamination
    Guide Progenitor Cell Allocation through a Dragging Mechanism.” <i>ELife</i>,
    vol. 10, e66483, eLife Sciences Publications, 2021, doi:<a href="https://doi.org/10.7554/eLife.66483">10.7554/eLife.66483</a>.
  short: E. Pulgar, C. Schwayer, N. Guerrero, L. López, S. Márquez, S. Härtel, R.
    Soto, C.P. Heisenberg, M.L. Concha, ELife 10 (2021).
date_created: 2021-09-12T22:01:23Z
date_published: 2021-08-27T00:00:00Z
date_updated: 2023-08-14T06:53:33Z
day: '27'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.7554/eLife.66483
ec_funded: 1
external_id:
  isi:
  - '000700428500001'
  pmid:
  - '34448451'
file:
- access_level: open_access
  checksum: a3f82b0499cc822ac1eab48a01f3f57e
  content_type: application/pdf
  creator: dernst
  date_created: 2022-05-13T08:03:37Z
  date_updated: 2022-05-13T08:03:37Z
  file_id: '11371'
  file_name: 2021_eLife_Pulgar.pdf
  file_size: 9010446
  relation: main_file
  success: 1
file_date_updated: 2022-05-13T08:03:37Z
has_accepted_license: '1'
intvolume: '        10'
isi: 1
keyword:
- cell delamination
- apical constriction
- dragging
- mechanical forces
- collective 18 locomotion
- dorsal forerunner cells
- zebrafish
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '742573'
  name: Interaction and feedback between cell mechanics and fate specification in
    vertebrate gastrulation
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: Apical contacts stemming from incomplete delamination guide progenitor cell
  allocation through a dragging mechanism
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2021'
...