---
_id: '10815'
abstract:
- lang: eng
  text: In the last several decades, developmental biology has clarified the molecular
    mechanisms of embryogenesis and organogenesis. In particular, it has demonstrated
    that the “tool-kit genes” essential for regulating developmental processes are
    not only highly conserved among species, but are also used as systems at various
    times and places in an organism to control distinct developmental events. Therefore,
    mutations in many of these tool-kit genes may cause congenital diseases involving
    morphological abnormalities. This link between genes and abnormal morphological
    phenotypes underscores the importance of understanding how cells behave and contribute
    to morphogenesis as a result of gene function. Recent improvements in live imaging
    and in quantitative analyses of cellular dynamics will advance our understanding
    of the cellular pathogenesis of congenital diseases associated with aberrant morphologies.
    In these studies, it is critical to select an appropriate model organism for the
    particular phenomenon of interest.
acknowledgement: The authors thank all the members of the Division of Morphogenesis,
  National Institute for Basic Biology, for their contributions to the research, their
  encouragement, and helpful discussions, particularly Dr M. Suzuki for his critical
  reading of the manuscript. We also thank the Model Animal Research and Spectrography
  and Bioimaging Facilities, NIBB Core Research Facilities, for technical support.
  M.H. was supported by a research fellowship from the Japan Society for the Promotion
  of Science (JSPS). Our work introduced in this review was supported by a Grant-in-Aid
  for Scientific Research on Innovative Areas from the Ministry of Education, Culture,
  Sports, Science, and Technology (MEXT), Japan, to N.U.
article_processing_charge: No
article_type: original
author:
- first_name: Masakazu
  full_name: Hashimoto, Masakazu
  last_name: Hashimoto
- first_name: Hitoshi
  full_name: Morita, Hitoshi
  id: 4C6E54C6-F248-11E8-B48F-1D18A9856A87
  last_name: Morita
- first_name: Naoto
  full_name: Ueno, Naoto
  last_name: Ueno
citation:
  ama: Hashimoto M, Morita H, Ueno N. Molecular and cellular mechanisms of development
    underlying congenital diseases. <i>Congenital Anomalies</i>. 2014;54(1):1-7. doi:<a
    href="https://doi.org/10.1111/cga.12039">10.1111/cga.12039</a>
  apa: Hashimoto, M., Morita, H., &#38; Ueno, N. (2014). Molecular and cellular mechanisms
    of development underlying congenital diseases. <i>Congenital Anomalies</i>. Wiley.
    <a href="https://doi.org/10.1111/cga.12039">https://doi.org/10.1111/cga.12039</a>
  chicago: Hashimoto, Masakazu, Hitoshi Morita, and Naoto Ueno. “Molecular and Cellular
    Mechanisms of Development Underlying Congenital Diseases.” <i>Congenital Anomalies</i>.
    Wiley, 2014. <a href="https://doi.org/10.1111/cga.12039">https://doi.org/10.1111/cga.12039</a>.
  ieee: M. Hashimoto, H. Morita, and N. Ueno, “Molecular and cellular mechanisms of
    development underlying congenital diseases,” <i>Congenital Anomalies</i>, vol.
    54, no. 1. Wiley, pp. 1–7, 2014.
  ista: Hashimoto M, Morita H, Ueno N. 2014. Molecular and cellular mechanisms of
    development underlying congenital diseases. Congenital Anomalies. 54(1), 1–7.
  mla: Hashimoto, Masakazu, et al. “Molecular and Cellular Mechanisms of Development
    Underlying Congenital Diseases.” <i>Congenital Anomalies</i>, vol. 54, no. 1,
    Wiley, 2014, pp. 1–7, doi:<a href="https://doi.org/10.1111/cga.12039">10.1111/cga.12039</a>.
  short: M. Hashimoto, H. Morita, N. Ueno, Congenital Anomalies 54 (2014) 1–7.
date_created: 2022-03-04T08:17:25Z
date_published: 2014-02-01T00:00:00Z
date_updated: 2022-03-04T08:26:05Z
day: '01'
department:
- _id: CaHe
doi: 10.1111/cga.12039
external_id:
  pmid:
  - '24666178'
intvolume: '        54'
issue: '1'
keyword:
- Developmental Biology
- Embryology
- General Medicine
- Pediatrics
- Perinatology
- and Child Health
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1111/cga.12039
month: '02'
oa: 1
oa_version: None
page: 1-7
pmid: 1
publication: Congenital Anomalies
publication_identifier:
  issn:
  - 0914-3505
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular and cellular mechanisms of development underlying congenital diseases
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2014'
...