[{"pmid":1,"department":[{"_id":"MaSe"}],"acknowledgement":"We thank many members of the Harvard AMO community, particularly E. Urbach, S. Dakoulas, and J. Doyle for their efforts enabling safe and productive operation of our laboratories during 2020. We thank D. Abanin, I. Cong, F. Machado, H. Pichler, N. Yao, B. Ye, and H. Zhou for stimulating discussions. Funding: We acknowledge financial support from the Center for Ultracold Atoms, the National Science Foundation, the Vannevar Bush Faculty Fellowship, the U.S. Department of Energy (LBNL QSA Center and grant no. DE-SC0021013), the Office of Naval Research, the Army Research Office MURI, the DARPA DRINQS program (grant no. D18AC00033), and the DARPA ONISQ program (grant no. W911NF2010021). The authors acknowledge support from the NSF Graduate Research Fellowship Program (grant DGE1745303) and The Fannie and John Hertz Foundation (D.B.); a National Defense Science and Engineering Graduate (NDSEG) fellowship (H.L.); a fellowship from the Max Planck/Harvard Research Center for Quantum Optics (G.S.); Gordon College (T.T.W.); the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 850899) (A.A.M. and M.S.); a Department of Energy Computational Science Graduate Fellowship under award number DE-SC0021110 (N.M.); the Moore Foundation’s EPiQS Initiative grant no. GBMF4306, the NUS Development grant AY2019/2020, and the Stanford Institute of Theoretical Physics (W.W.H.); and the Miller Institute for Basic Research in Science (S.C.). Author contributions: D.B., A.O., H.L., A.K., G.S., S.E., and T.T.W. contributed to the building of the experimental setup, performed the measurements, and analyzed the data. A.A.M., N.M., W.W.H., S.C., and M.S. performed theoretical analysis. All work was supervised by M.G., V.V., and M.D.L. All authors discussed the results and contributed to the manuscript. Competing interests: M.G., V.V., and M.D.L. are co-founders and shareholders of QuEra Computing. A.O. is a shareholder of QuEra Computing. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and the supplementary materials.","date_created":"2021-06-29T12:04:05Z","keyword":["Multidisciplinary"],"intvolume":"       371","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","ddc":["539"],"file_date_updated":"2021-09-23T14:00:05Z","quality_controlled":"1","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"month":"03","volume":371,"article_type":"original","isi":1,"publisher":"AAAS","year":"2021","language":[{"iso":"eng"}],"doi":"10.1126/science.abg2530","type":"journal_article","oa":1,"_id":"9618","author":[{"full_name":"Bluvstein, D.","first_name":"D.","last_name":"Bluvstein"},{"first_name":"A.","full_name":"Omran, A.","last_name":"Omran"},{"last_name":"Levine","full_name":"Levine, H.","first_name":"H."},{"last_name":"Keesling","first_name":"A.","full_name":"Keesling, A."},{"full_name":"Semeghini, G.","first_name":"G.","last_name":"Semeghini"},{"first_name":"S.","full_name":"Ebadi, S.","last_name":"Ebadi"},{"first_name":"T. T.","full_name":"Wang, T. T.","last_name":"Wang"},{"full_name":"Michailidis, Alexios","first_name":"Alexios","orcid":"0000-0002-8443-1064","last_name":"Michailidis","id":"36EBAD38-F248-11E8-B48F-1D18A9856A87"},{"first_name":"N.","full_name":"Maskara, N.","last_name":"Maskara"},{"last_name":"Ho","full_name":"Ho, W. W.","first_name":"W. W."},{"full_name":"Choi, S.","first_name":"S.","last_name":"Choi"},{"id":"47809E7E-F248-11E8-B48F-1D18A9856A87","last_name":"Serbyn","orcid":"0000-0002-2399-5827","first_name":"Maksym","full_name":"Serbyn, Maksym"},{"first_name":"M.","full_name":"Greiner, M.","last_name":"Greiner"},{"first_name":"V.","full_name":"Vuletić, V.","last_name":"Vuletić"},{"first_name":"M. D.","full_name":"Lukin, M. D.","last_name":"Lukin"}],"date_published":"2021-03-26T00:00:00Z","project":[{"_id":"23841C26-32DE-11EA-91FC-C7463DDC885E","name":"Non-Ergodic Quantum Matter: Universality, Dynamics and Control","call_identifier":"H2020","grant_number":"850899"}],"citation":{"ista":"Bluvstein D, Omran A, Levine H, Keesling A, Semeghini G, Ebadi S, Wang TT, Michailidis A, Maskara N, Ho WW, Choi S, Serbyn M, Greiner M, Vuletić V, Lukin MD. 2021. Controlling quantum many-body dynamics in driven Rydberg atom arrays. Science. 371(6536), 1355–1359.","apa":"Bluvstein, D., Omran, A., Levine, H., Keesling, A., Semeghini, G., Ebadi, S., … Lukin, M. D. (2021). Controlling quantum many-body dynamics in driven Rydberg atom arrays. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.abg2530\">https://doi.org/10.1126/science.abg2530</a>","mla":"Bluvstein, D., et al. “Controlling Quantum Many-Body Dynamics in Driven Rydberg Atom Arrays.” <i>Science</i>, vol. 371, no. 6536, AAAS, 2021, pp. 1355–59, doi:<a href=\"https://doi.org/10.1126/science.abg2530\">10.1126/science.abg2530</a>.","short":"D. Bluvstein, A. Omran, H. Levine, A. Keesling, G. Semeghini, S. Ebadi, T.T. Wang, A. Michailidis, N. Maskara, W.W. Ho, S. Choi, M. Serbyn, M. Greiner, V. Vuletić, M.D. Lukin, Science 371 (2021) 1355–1359.","ama":"Bluvstein D, Omran A, Levine H, et al. Controlling quantum many-body dynamics in driven Rydberg atom arrays. <i>Science</i>. 2021;371(6536):1355-1359. doi:<a href=\"https://doi.org/10.1126/science.abg2530\">10.1126/science.abg2530</a>","chicago":"Bluvstein, D., A. Omran, H. Levine, A. Keesling, G. Semeghini, S. Ebadi, T. T. Wang, et al. “Controlling Quantum Many-Body Dynamics in Driven Rydberg Atom Arrays.” <i>Science</i>. AAAS, 2021. <a href=\"https://doi.org/10.1126/science.abg2530\">https://doi.org/10.1126/science.abg2530</a>.","ieee":"D. Bluvstein <i>et al.</i>, “Controlling quantum many-body dynamics in driven Rydberg atom arrays,” <i>Science</i>, vol. 371, no. 6536. AAAS, pp. 1355–1359, 2021."},"arxiv":1,"has_accepted_license":"1","issue":"6536","scopus_import":"1","external_id":{"isi":["000636043400048"],"arxiv":["2012.12276"],"pmid":["33632894"]},"title":"Controlling quantum many-body dynamics in driven Rydberg atom arrays","file":[{"success":1,"date_updated":"2021-09-23T14:00:05Z","file_id":"10040","checksum":"0b356fd10ab9bb95177d4c047d4e9c1a","date_created":"2021-09-23T14:00:05Z","file_size":3671159,"file_name":"scars_subharmonic_combined_manuscript_2_11_2021 (2)-1.pdf","content_type":"application/pdf","relation":"main_file","access_level":"open_access","creator":"patrickd"}],"publication":"Science","date_updated":"2023-08-10T13:57:07Z","status":"public","ec_funded":1,"abstract":[{"lang":"eng","text":"The control of nonequilibrium quantum dynamics in many-body systems is challenging because interactions typically lead to thermalization and a chaotic spreading throughout Hilbert space. We investigate nonequilibrium dynamics after rapid quenches in a many-body system composed of 3 to 200 strongly interacting qubits in one and two spatial dimensions. Using a programmable quantum simulator based on Rydberg atom arrays, we show that coherent revivals associated with so-called quantum many-body scars can be stabilized by periodic driving, which generates a robust subharmonic response akin to discrete time-crystalline order. We map Hilbert space dynamics, geometry dependence, phase diagrams, and system-size dependence of this emergent phenomenon, demonstrating new ways to steer complex dynamics in many-body systems and enabling potential applications in quantum information science."}],"oa_version":"Preprint","page":"1355-1359","publication_status":"published","day":"26"},{"isi":1,"article_type":"original","month":"09","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"quality_controlled":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","keyword":["condensed matter - mesoscale and nanoscale physics","condensed matter - strongly correlated electrons","multidisciplinary"],"date_created":"2021-09-19T22:01:25Z","department":[{"_id":"MaSe"},{"_id":"MiLe"}],"acknowledgement":"The authors acknowledge discussions with A. Macdonald, L. Fu, F. Wang and M. Zaletel. AFY acknowledges support of the National Science Foundation under DMR1654186, and the Gordon and Betty Moore Foundation under award GBMF9471. The authors acknowledge the use of the research facilities within the California NanoSystems Institute, supported by the University of California, Santa Barbara and the University of California, Office of the President.\r\nK.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan, Grant Number JPMXP0112101001 and JSPS KAKENHI, Grant Number JP20H00354. EB and TH were supported by the European Research Council (ERC) under grant HQMAT (Grant Agreement No. 817799). A.G. acknowledges support by the European Unions Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Grant Agreement\r\nNo. 754411.\r\n","date_published":"2021-09-01T00:00:00Z","author":[{"full_name":"Zhou, Haoxin","first_name":"Haoxin","last_name":"Zhou"},{"last_name":"Xie","full_name":"Xie, Tian","first_name":"Tian"},{"first_name":"Areg","full_name":"Ghazaryan, Areg","last_name":"Ghazaryan","id":"4AF46FD6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9666-3543"},{"first_name":"Tobias","full_name":"Holder, Tobias","last_name":"Holder"},{"last_name":"Ehrets","first_name":"James R.","full_name":"Ehrets, James R."},{"last_name":"Spanton","full_name":"Spanton, Eric M.","first_name":"Eric M."},{"full_name":"Taniguchi, Takashi","first_name":"Takashi","last_name":"Taniguchi"},{"full_name":"Watanabe, Kenji","first_name":"Kenji","last_name":"Watanabe"},{"first_name":"Erez","full_name":"Berg, Erez","last_name":"Berg"},{"orcid":"0000-0002-2399-5827","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","last_name":"Serbyn","first_name":"Maksym","full_name":"Serbyn, Maksym"},{"last_name":"Young","full_name":"Young, Andrea F.","first_name":"Andrea F."}],"_id":"10025","oa":1,"type":"journal_article","doi":"10.1038/s41586-021-03938-w","language":[{"iso":"eng"}],"year":"2021","publisher":"Springer Nature","publication":"Nature","title":"Half and quarter metals in rhombohedral trilayer graphene","external_id":{"isi":["000706977400002"],"arxiv":["2104.00653"]},"related_material":{"link":[{"url":"https://doi.org/10.1038/s41586-021-04181-z","relation":"erratum"}]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2104.00653"}],"scopus_import":"1","citation":{"ama":"Zhou H, Xie T, Ghazaryan A, et al. Half and quarter metals in rhombohedral trilayer graphene. <i>Nature</i>. 2021. doi:<a href=\"https://doi.org/10.1038/s41586-021-03938-w\">10.1038/s41586-021-03938-w</a>","short":"H. Zhou, T. Xie, A. Ghazaryan, T. Holder, J.R. Ehrets, E.M. Spanton, T. Taniguchi, K. Watanabe, E. Berg, M. Serbyn, A.F. Young, Nature (2021).","apa":"Zhou, H., Xie, T., Ghazaryan, A., Holder, T., Ehrets, J. R., Spanton, E. M., … Young, A. F. (2021). Half and quarter metals in rhombohedral trilayer graphene. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-021-03938-w\">https://doi.org/10.1038/s41586-021-03938-w</a>","ista":"Zhou H, Xie T, Ghazaryan A, Holder T, Ehrets JR, Spanton EM, Taniguchi T, Watanabe K, Berg E, Serbyn M, Young AF. 2021. Half and quarter metals in rhombohedral trilayer graphene. Nature.","mla":"Zhou, Haoxin, et al. “Half and Quarter Metals in Rhombohedral Trilayer Graphene.” <i>Nature</i>, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41586-021-03938-w\">10.1038/s41586-021-03938-w</a>.","ieee":"H. Zhou <i>et al.</i>, “Half and quarter metals in rhombohedral trilayer graphene,” <i>Nature</i>. Springer Nature, 2021.","chicago":"Zhou, Haoxin, Tian Xie, Areg Ghazaryan, Tobias Holder, James R. Ehrets, Eric M. Spanton, Takashi Taniguchi, et al. “Half and Quarter Metals in Rhombohedral Trilayer Graphene.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-021-03938-w\">https://doi.org/10.1038/s41586-021-03938-w</a>."},"arxiv":1,"project":[{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411","call_identifier":"H2020"}],"day":"01","oa_version":"Preprint","publication_status":"published","abstract":[{"lang":"eng","text":"Ferromagnetism is most common in transition metal compounds but may also arise in low-density two-dimensional electron systems, with signatures observed in silicon, III-V semiconductor systems, and graphene moiré heterostructures. Here we show that gate-tuned van Hove singularities in rhombohedral trilayer graphene drive the spontaneous ferromagnetic polarization of the electron system into one or more spin- and valley flavors. Using capacitance measurements on graphite-gated van der Waals heterostructures, we find a cascade of density- and electronic displacement field tuned phase transitions marked by negative electronic compressibility. The transitions define the boundaries between phases where quantum oscillations have either four-fold, two-fold, or one-fold degeneracy, associated with a spin and valley degenerate normal metal, spin-polarized `half-metal', and spin and valley polarized `quarter metal', respectively. For electron doping, the salient features are well captured by a phenomenological Stoner model with a valley-anisotropic Hund's coupling, likely arising from interactions at the lattice scale. For hole filling, we observe a richer phase diagram featuring a delicate interplay of broken symmetries and transitions in the Fermi surface topology. Finally, by rotational alignment of a hexagonal boron nitride substrate to induce a moiré superlattice, we find that the superlattice perturbs the preexisting isospin order only weakly, leaving the basic phase diagram intact while catalyzing the formation of topologically nontrivial gapped states whenever itinerant half- or quarter metal states occur at half- or quarter superlattice band filling. Our results show that rhombohedral trilayer graphene is an ideal platform for well-controlled tests of many-body theory and reveal magnetism in moiré materials to be fundamentally itinerant in nature."}],"ec_funded":1,"status":"public","date_updated":"2023-08-14T07:04:06Z"},{"type":"journal_article","year":"2021","publisher":"Springer Nature","doi":"10.1038/s41586-021-04037-6","language":[{"iso":"eng"}],"date_published":"2021-11-11T00:00:00Z","_id":"10223","oa":1,"author":[{"last_name":"Li","id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5607-272X","first_name":"Lanxin","full_name":"Li, Lanxin"},{"orcid":"0000-0001-7241-2328","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87","last_name":"Verstraeten","first_name":"Inge","full_name":"Verstraeten, Inge"},{"last_name":"Roosjen","full_name":"Roosjen, Mark","first_name":"Mark"},{"last_name":"Takahashi","full_name":"Takahashi, Koji","first_name":"Koji"},{"orcid":"0000-0002-7244-7237","id":"3922B506-F248-11E8-B48F-1D18A9856A87","last_name":"Rodriguez Solovey","full_name":"Rodriguez Solovey, Lesia","first_name":"Lesia"},{"first_name":"Jack","full_name":"Merrin, Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","last_name":"Merrin","orcid":"0000-0001-5145-4609"},{"first_name":"Jian","full_name":"Chen, Jian","last_name":"Chen"},{"last_name":"Shabala","first_name":"Lana","full_name":"Shabala, Lana"},{"last_name":"Smet","full_name":"Smet, Wouter","first_name":"Wouter"},{"last_name":"Ren","first_name":"Hong","full_name":"Ren, Hong"},{"full_name":"Vanneste, Steffen","first_name":"Steffen","last_name":"Vanneste"},{"last_name":"Shabala","first_name":"Sergey","full_name":"Shabala, Sergey"},{"last_name":"De Rybel","full_name":"De Rybel, Bert","first_name":"Bert"},{"last_name":"Weijers","first_name":"Dolf","full_name":"Weijers, Dolf"},{"first_name":"Toshinori","full_name":"Kinoshita, Toshinori","last_name":"Kinoshita"},{"last_name":"Gray","full_name":"Gray, William M.","first_name":"William M."},{"orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří"}],"intvolume":"       599","keyword":["Multidisciplinary"],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_processing_charge":"No","acknowledgement":"We thank N. Gnyliukh and L. Hörmayer for technical assistance and N. Paris for sharing PM-Cyto seeds. We gratefully acknowledge the Life Science, Machine Shop and Bioimaging Facilities of IST Austria. This project has received funding from the European Research Council Advanced Grant (ETAP-742985) and the Austrian Science Fund (FWF) under I 3630-B25 to J.F., the National Institutes of Health (GM067203) to W.M.G., the Netherlands Organization for Scientific Research (NWO; VIDI-864.13.001), Research Foundation-Flanders (FWO; Odysseus II G0D0515N) and a European Research Council Starting Grant (TORPEDO-714055) to W.S. and B.D.R., the VICI grant (865.14.001) from the Netherlands Organization for Scientific Research to M.R. and D.W., the Australian Research Council and China National Distinguished Expert Project (WQ20174400441) to S.S., the MEXT/JSPS KAKENHI to K.T. (20K06685) and T.K. (20H05687 and 20H05910), the European Union’s Horizon 2020 research and innovation programme under Marie Skłodowska-Curie grant agreement no. 665385 and the DOC Fellowship of the Austrian Academy of Sciences to L.L., and the China Scholarship Council to J.C.","department":[{"_id":"JiFr"},{"_id":"NanoFab"}],"pmid":1,"date_created":"2021-11-07T23:01:25Z","volume":599,"article_type":"original","isi":1,"publication_identifier":{"issn":["00280836"],"eissn":["14764687"]},"quality_controlled":"1","month":"11","status":"public","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"Bio"}],"date_updated":"2024-10-29T10:22:45Z","abstract":[{"text":"Growth regulation tailors development in plants to their environment. A prominent example of this is the response to gravity, in which shoots bend up and roots bend down1. This paradox is based on opposite effects of the phytohormone auxin, which promotes cell expansion in shoots while inhibiting it in roots via a yet unknown cellular mechanism2. Here, by combining microfluidics, live imaging, genetic engineering and phosphoproteomics in Arabidopsis thaliana, we advance understanding of how auxin inhibits root growth. We show that auxin activates two distinct, antagonistically acting signalling pathways that converge on rapid regulation of apoplastic pH, a causative determinant of growth. Cell surface-based TRANSMEMBRANE KINASE1 (TMK1) interacts with and mediates phosphorylation and activation of plasma membrane H+-ATPases for apoplast acidification, while intracellular canonical auxin signalling promotes net cellular H+ influx, causing apoplast alkalinization. Simultaneous activation of these two counteracting mechanisms poises roots for rapid, fine-tuned growth modulation in navigating complex soil environments.","lang":"eng"}],"ec_funded":1,"day":"11","page":"273-277","oa_version":"Preprint","publication_status":"published","scopus_import":"1","issue":"7884","citation":{"ama":"Li L, Verstraeten I, Roosjen M, et al. Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth. <i>Nature</i>. 2021;599(7884):273-277. doi:<a href=\"https://doi.org/10.1038/s41586-021-04037-6\">10.1038/s41586-021-04037-6</a>","mla":"Li, Lanxin, et al. “Cell Surface and Intracellular Auxin Signalling for H<sup>+</sup> Fluxes in Root Growth.” <i>Nature</i>, vol. 599, no. 7884, Springer Nature, 2021, pp. 273–77, doi:<a href=\"https://doi.org/10.1038/s41586-021-04037-6\">10.1038/s41586-021-04037-6</a>.","short":"L. Li, I. Verstraeten, M. Roosjen, K. Takahashi, L. Rodriguez Solovey, J. Merrin, J. Chen, L. Shabala, W. Smet, H. Ren, S. Vanneste, S. Shabala, B. De Rybel, D. Weijers, T. Kinoshita, W.M. Gray, J. Friml, Nature 599 (2021) 273–277.","apa":"Li, L., Verstraeten, I., Roosjen, M., Takahashi, K., Rodriguez Solovey, L., Merrin, J., … Friml, J. (2021). Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-021-04037-6\">https://doi.org/10.1038/s41586-021-04037-6</a>","ista":"Li L, Verstraeten I, Roosjen M, Takahashi K, Rodriguez Solovey L, Merrin J, Chen J, Shabala L, Smet W, Ren H, Vanneste S, Shabala S, De Rybel B, Weijers D, Kinoshita T, Gray WM, Friml J. 2021. Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth. Nature. 599(7884), 273–277.","ieee":"L. Li <i>et al.</i>, “Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth,” <i>Nature</i>, vol. 599, no. 7884. Springer Nature, pp. 273–277, 2021.","chicago":"Li, Lanxin, Inge Verstraeten, Mark Roosjen, Koji Takahashi, Lesia Rodriguez Solovey, Jack Merrin, Jian Chen, et al. “Cell Surface and Intracellular Auxin Signalling for H<sup>+</sup> Fluxes in Root Growth.” <i>Nature</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41586-021-04037-6\">https://doi.org/10.1038/s41586-021-04037-6</a>."},"project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","call_identifier":"H2020"},{"call_identifier":"FWF","grant_number":"I03630","name":"Molecular mechanisms of endocytic cargo recognition in plants","_id":"26538374-B435-11E9-9278-68D0E5697425"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020"},{"name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root","_id":"26B4D67E-B435-11E9-9278-68D0E5697425","grant_number":"25351"}],"title":"Cell surface and intracellular auxin signalling for H<sup>+</sup> fluxes in root growth","external_id":{"isi":["000713338100006"],"pmid":["34707283"]},"related_material":{"link":[{"url":"https://ist.ac.at/en/news/stop-and-grow/","relation":"press_release","description":"News on IST Webpage"}],"record":[{"status":"public","id":"10095","relation":"earlier_version"}]},"publication":"Nature","main_file_link":[{"open_access":"1","url":"https://www.doi.org/10.21203/rs.3.rs-266395/v3"}]},{"abstract":[{"lang":"eng","text":"Turbulence generally arises in shear flows if velocities and hence, inertial forces are sufficiently large. In striking contrast, viscoelastic fluids can exhibit disordered motion even at vanishing inertia. Intermediate between these cases, a state of chaotic motion, “elastoinertial turbulence” (EIT), has been observed in a narrow Reynolds number interval. We here determine the origin of EIT in experiments and show that characteristic EIT structures can be detected across an unexpectedly wide range of parameters. Close to onset, a pattern of chevron-shaped streaks emerges in qualitative agreement with linear and weakly nonlinear theory. However, in experiments, the dynamics remain weakly chaotic, and the instability can be traced to far lower Reynolds numbers than permitted by theory. For increasing inertia, the flow undergoes a transformation to a wall mode composed of inclined near-wall streaks and shear layers. This mode persists to what is known as the “maximum drag reduction limit,” and overall EIT is found to dominate viscoelastic flows across more than three orders of magnitude in Reynolds number."}],"day":"03","publication_status":"published","oa_version":"Preprint","status":"public","date_updated":"2023-08-14T11:50:10Z","title":"Experimental observation of the origin and structure of elastoinertial turbulence","external_id":{"arxiv":["2103.00023"],"pmid":[" 34732570"],"isi":["000720926900019"]},"publication":"Proceedings of the National Academy of Sciences","main_file_link":[{"url":"https://arxiv.org/abs/2103.00023","open_access":"1"}],"scopus_import":"1","issue":"45","arxiv":1,"citation":{"apa":"Choueiri, G. H., Lopez Alonso, J. M., Varshney, A., Sankar, S., &#38; Hof, B. (2021). Experimental observation of the origin and structure of elastoinertial turbulence. <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2102350118\">https://doi.org/10.1073/pnas.2102350118</a>","mla":"Choueiri, George H., et al. “Experimental Observation of the Origin and Structure of Elastoinertial Turbulence.” <i>Proceedings of the National Academy of Sciences</i>, vol. 118, no. 45, e2102350118, National Academy of Sciences, 2021, doi:<a href=\"https://doi.org/10.1073/pnas.2102350118\">10.1073/pnas.2102350118</a>.","ista":"Choueiri GH, Lopez Alonso JM, Varshney A, Sankar S, Hof B. 2021. Experimental observation of the origin and structure of elastoinertial turbulence. Proceedings of the National Academy of Sciences. 118(45), e2102350118.","short":"G.H. Choueiri, J.M. Lopez Alonso, A. Varshney, S. Sankar, B. Hof, Proceedings of the National Academy of Sciences 118 (2021).","ama":"Choueiri GH, Lopez Alonso JM, Varshney A, Sankar S, Hof B. Experimental observation of the origin and structure of elastoinertial turbulence. <i>Proceedings of the National Academy of Sciences</i>. 2021;118(45). doi:<a href=\"https://doi.org/10.1073/pnas.2102350118\">10.1073/pnas.2102350118</a>","chicago":"Choueiri, George H, Jose M Lopez Alonso, Atul Varshney, Sarath Sankar, and Björn Hof. “Experimental Observation of the Origin and Structure of Elastoinertial Turbulence.” <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences, 2021. <a href=\"https://doi.org/10.1073/pnas.2102350118\">https://doi.org/10.1073/pnas.2102350118</a>.","ieee":"G. H. Choueiri, J. M. Lopez Alonso, A. Varshney, S. Sankar, and B. Hof, “Experimental observation of the origin and structure of elastoinertial turbulence,” <i>Proceedings of the National Academy of Sciences</i>, vol. 118, no. 45. National Academy of Sciences, 2021."},"project":[{"grant_number":"I04188","call_identifier":"FWF","_id":"238B8092-32DE-11EA-91FC-C7463DDC885E","name":"Instabilities in pulsating pipe flow of Newtonian and complex fluids"}],"date_published":"2021-11-03T00:00:00Z","_id":"10299","oa":1,"author":[{"last_name":"Choueiri","id":"448BD5BC-F248-11E8-B48F-1D18A9856A87","full_name":"Choueiri, George H","first_name":"George H"},{"last_name":"Lopez Alonso","id":"40770848-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0384-2022","first_name":"Jose M","full_name":"Lopez Alonso, Jose M"},{"id":"2A2006B2-F248-11E8-B48F-1D18A9856A87","last_name":"Varshney","orcid":"0000-0002-3072-5999","first_name":"Atul","full_name":"Varshney, Atul"},{"first_name":"Sarath","full_name":"Sankar, Sarath","last_name":"Sankar"},{"first_name":"Björn","full_name":"Hof, Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","last_name":"Hof","orcid":"0000-0003-2057-2754"}],"type":"journal_article","year":"2021","publisher":"National Academy of Sciences","doi":"10.1073/pnas.2102350118","language":[{"iso":"eng"}],"volume":118,"article_type":"original","isi":1,"publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"quality_controlled":"1","month":"11","intvolume":"       118","keyword":["multidisciplinary","elastoinertial turbulence","viscoelastic flows","elastic instability","drag reduction"],"article_processing_charge":"No","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"We thank Y. Dubief, R. Kerswell, E. Marensi, V. Shankar, V. Steinberg, and V. Terrapon for discussions and helpful comments. A.V. and B.H. acknowledge funding from the Austrian Science Fund, grant I4188-N30, within the Deutsche Forschungsgemeinschaft research unit FOR 2688.","department":[{"_id":"BjHo"}],"pmid":1,"article_number":"e2102350118","date_created":"2021-11-17T13:24:24Z"},{"status":"public","date_updated":"2022-01-13T14:11:36Z","abstract":[{"text":"Electrons in moiré flat band systems can spontaneously break time-reversal symmetry, giving rise to a quantized anomalous Hall effect. In this study, we use a superconducting quantum interference device to image stray magnetic fields in twisted bilayer graphene aligned to hexagonal boron nitride. We find a magnetization of several Bohr magnetons per charge carrier, demonstrating that the magnetism is primarily orbital in nature. Our measurements reveal a large change in the magnetization as the chemical potential is swept across the quantum anomalous Hall gap, consistent with the expected contribution of chiral edge states to the magnetization of an orbital Chern insulator. Mapping the spatial evolution of field-driven magnetic reversal, we find a series of reproducible micrometer-scale domains pinned to structural disorder.","lang":"eng"}],"day":"27","publication_status":"published","oa_version":"Preprint","page":"1323-1327","scopus_import":"1","issue":"6548","citation":{"ieee":"C. L. Tschirhart <i>et al.</i>, “Imaging orbital ferromagnetism in a moiré Chern insulator,” <i>Science</i>, vol. 372, no. 6548. American Association for the Advancement of Science, pp. 1323–1327, 2021.","chicago":"Tschirhart, C. L., M. Serlin, Hryhoriy Polshyn, A. Shragai, Z. Xia, J. Zhu, Y. Zhang, et al. “Imaging Orbital Ferromagnetism in a Moiré Chern Insulator.” <i>Science</i>. American Association for the Advancement of Science, 2021. <a href=\"https://doi.org/10.1126/science.abd3190\">https://doi.org/10.1126/science.abd3190</a>.","ama":"Tschirhart CL, Serlin M, Polshyn H, et al. Imaging orbital ferromagnetism in a moiré Chern insulator. <i>Science</i>. 2021;372(6548):1323-1327. doi:<a href=\"https://doi.org/10.1126/science.abd3190\">10.1126/science.abd3190</a>","short":"C.L. Tschirhart, M. Serlin, H. Polshyn, A. Shragai, Z. Xia, J. Zhu, Y. Zhang, K. Watanabe, T. Taniguchi, M.E. Huber, A.F. Young, Science 372 (2021) 1323–1327.","ista":"Tschirhart CL, Serlin M, Polshyn H, Shragai A, Xia Z, Zhu J, Zhang Y, Watanabe K, Taniguchi T, Huber ME, Young AF. 2021. Imaging orbital ferromagnetism in a moiré Chern insulator. Science. 372(6548), 1323–1327.","mla":"Tschirhart, C. L., et al. “Imaging Orbital Ferromagnetism in a Moiré Chern Insulator.” <i>Science</i>, vol. 372, no. 6548, American Association for the Advancement of Science, 2021, pp. 1323–27, doi:<a href=\"https://doi.org/10.1126/science.abd3190\">10.1126/science.abd3190</a>.","apa":"Tschirhart, C. L., Serlin, M., Polshyn, H., Shragai, A., Xia, Z., Zhu, J., … Young, A. F. (2021). Imaging orbital ferromagnetism in a moiré Chern insulator. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abd3190\">https://doi.org/10.1126/science.abd3190</a>"},"arxiv":1,"title":"Imaging orbital ferromagnetism in a moiré Chern insulator","external_id":{"arxiv":["2006.08053"],"pmid":["34045322"]},"publication":"Science","main_file_link":[{"url":"https://arxiv.org/abs/2006.08053","open_access":"1"}],"type":"journal_article","year":"2021","publisher":"American Association for the Advancement of Science","doi":"10.1126/science.abd3190","language":[{"iso":"eng"}],"date_published":"2021-05-27T00:00:00Z","_id":"10616","oa":1,"author":[{"first_name":"C. L.","full_name":"Tschirhart, C. L.","last_name":"Tschirhart"},{"full_name":"Serlin, M.","first_name":"M.","last_name":"Serlin"},{"first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","orcid":"0000-0001-8223-8896"},{"first_name":"A.","full_name":"Shragai, A.","last_name":"Shragai"},{"first_name":"Z.","full_name":"Xia, Z.","last_name":"Xia"},{"full_name":"Zhu, J.","first_name":"J.","last_name":"Zhu"},{"last_name":"Zhang","full_name":"Zhang, Y.","first_name":"Y."},{"full_name":"Watanabe, K.","first_name":"K.","last_name":"Watanabe"},{"full_name":"Taniguchi, T.","first_name":"T.","last_name":"Taniguchi"},{"last_name":"Huber","first_name":"M. E.","full_name":"Huber, M. E."},{"full_name":"Young, A. F.","first_name":"A. F.","last_name":"Young"}],"intvolume":"       372","keyword":["multidisciplinary"],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","extern":"1","acknowledgement":"We thank A. H. Macdonald, J. Zhu, M. Zaletel, and D. Xiao for discussions of the results and E. Lachman for comments on the manuscript. Funding: The work was primarily funded by the US Department of Energy under DE-SC0020043, with additional support for instrumentation development supported by the Army Research Office under grant W911NF-16-1-0361. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by MEXT, Japan, grant JPMXP0112101001; JSPS KAKENHI grant JP20H00354 and CREST grant JPMJCR15F3, JST. C.L.T. acknowledges support from the Hertz Foundation and from the National Science Foundation Graduate Research Fellowship Program under grant 1650114. This project is funded in part by the Gordon and Betty Moore Foundation’s EPiQS Initiative, grant GBMF9471 to A.F.Y.","pmid":1,"date_created":"2022-01-13T12:17:45Z","article_type":"original","volume":372,"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"quality_controlled":"1","month":"05"},{"status":"public","date_updated":"2023-05-08T10:56:39Z","abstract":[{"text":"Genomes of germ cells present an existential vulnerability to organisms because germ cell mutations will propagate to future generations. Transposable elements are one source of such mutations. In the small flowering plant Arabidopsis, Long et al. found that genome methylation in the male germline is directed by small interfering RNAs (siRNAs) imperfectly transcribed from transposons (see the Perspective by Mosher). These germline siRNAs silence germline transposons and establish inherited methylation patterns in sperm, thus maintaining the integrity of the plant genome across generations.","lang":"eng"}],"publication_status":"published","oa_version":"None","day":"02","issue":"6550","scopus_import":"1","citation":{"ieee":"J. Long <i>et al.</i>, “Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis,” <i>Science</i>, vol. 373, no. 6550. American Association for the Advancement of Science (AAAS), 2021.","chicago":"Long, Jincheng, James Walker, Wenjing She, Billy Aldridge, Hongbo Gao, Samuel Deans, Martin Vickers, and Xiaoqi Feng. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic Inheritance in Arabidopsis.” <i>Science</i>. American Association for the Advancement of Science (AAAS), 2021. <a href=\"https://doi.org/10.1126/science.abh0556\">https://doi.org/10.1126/science.abh0556</a>.","ama":"Long J, Walker J, She W, et al. Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. <i>Science</i>. 2021;373(6550). doi:<a href=\"https://doi.org/10.1126/science.abh0556\">10.1126/science.abh0556</a>","apa":"Long, J., Walker, J., She, W., Aldridge, B., Gao, H., Deans, S., … Feng, X. (2021). Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. <i>Science</i>. American Association for the Advancement of Science (AAAS). <a href=\"https://doi.org/10.1126/science.abh0556\">https://doi.org/10.1126/science.abh0556</a>","ista":"Long J, Walker J, She W, Aldridge B, Gao H, Deans S, Vickers M, Feng X. 2021. Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis. Science. 373(6550).","mla":"Long, Jincheng, et al. “Nurse Cell--Derived Small RNAs Define Paternal Epigenetic Inheritance in Arabidopsis.” <i>Science</i>, vol. 373, no. 6550, American Association for the Advancement of Science (AAAS), 2021, doi:<a href=\"https://doi.org/10.1126/science.abh0556\">10.1126/science.abh0556</a>.","short":"J. Long, J. Walker, W. She, B. Aldridge, H. Gao, S. Deans, M. Vickers, X. Feng, Science 373 (2021)."},"external_id":{"pmid":["34210850"]},"title":"Nurse cell--derived small RNAs define paternal epigenetic inheritance in Arabidopsis","publication":"Science","type":"journal_article","publisher":"American Association for the Advancement of Science (AAAS)","year":"2021","language":[{"iso":"eng"}],"doi":"10.1126/science.abh0556","date_published":"2021-07-02T00:00:00Z","_id":"12187","author":[{"first_name":"Jincheng","full_name":"Long, Jincheng","last_name":"Long"},{"last_name":"Walker","full_name":"Walker, James","first_name":"James"},{"last_name":"She","full_name":"She, Wenjing","first_name":"Wenjing"},{"full_name":"Aldridge, Billy","first_name":"Billy","last_name":"Aldridge"},{"first_name":"Hongbo","full_name":"Gao, Hongbo","last_name":"Gao"},{"full_name":"Deans, Samuel","first_name":"Samuel","last_name":"Deans"},{"first_name":"Martin","full_name":"Vickers, Martin","last_name":"Vickers"},{"orcid":"0000-0002-4008-1234","last_name":"Feng","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","full_name":"Feng, Xiaoqi","first_name":"Xiaoqi"}],"keyword":["Multidisciplinary"],"intvolume":"       373","article_processing_charge":"No","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"acknowledgement":"We thank the John Innes Centre Bioimaging Facility (S. Lopez, E. Wegel, and K. Findlay) for their assistance with microscopy and the Norwich BioScience Institute Partnership Computing Infrastructure for Science Group for high-performance computing resources. Funding: This work was funded by a European Research Council Starting Grant (“SexMeth” 804981; J.L., J.W., and X.F.), a Sainsbury Charitable Foundation studentship (J.W.), two Biotechnology and Biological Sciences Research Council (BBSRC) grants (BBS0096201 and BBP0135111; W.S., M.V., and X.F.), two John Innes Foundation studentships (B.A. and S.D.), and a BBSRC David Phillips Fellowship (BBL0250431; H.G. and X.F.). Author contributions: J.L., J.W., and X.F. designed the study and wrote the manuscript; J.L., W.S., B.A., H.G., and S.D. performed the experiments; and J.L., J.W., B.A., H.G., S.D., M.V., and X.F. analyzed the data. Competing interests: The authors declare no competing interests. Data and material availability: All sequencing data have been deposited in the Gene Expression Omnibus (GEO) under accession no. GSE161625. Accession nos. of published datasets used in this study are listed in table S6. Published software used in this study include Bowtie v1.2.2 (https://doi.org/10.1002/0471250953.bi1107s32), Bismark v0.22.2 (https://doi.org/10.1093/bioinformatics/btr167), Kallisto v0.43.0 (https://doi.org/10.1038/nbt0816-888d), Shortstack v3.8.5 (https://doi.org/10.1534/g3.116.030452), and Cutadapt v1.15 (https://doi.org/10.1089/cmb.2017.0096). TrimGalore v0.4.1 and MarkDuplicates v1.141 are available from https://github.com/FelixKrueger/TrimGalore and https://github.com/broadinstitute/picard, respectively. All remaining data are in the main paper or the supplementary materials.","department":[{"_id":"XiFe"}],"date_created":"2023-01-16T09:15:14Z","volume":373,"article_type":"original","quality_controlled":"1","publication_identifier":{"issn":["0036-8075","1095-9203"]},"month":"07"},{"date_published":"2021-05-17T00:00:00Z","author":[{"first_name":"Evan","full_name":"Miles, Evan","last_name":"Miles"},{"first_name":"Michael","full_name":"McCarthy, Michael","last_name":"McCarthy"},{"last_name":"Dehecq","full_name":"Dehecq, Amaury","first_name":"Amaury"},{"first_name":"Marin","full_name":"Kneib, Marin","last_name":"Kneib"},{"last_name":"Fugger","full_name":"Fugger, Stefan","first_name":"Stefan"},{"full_name":"Pellicciotti, Francesca","first_name":"Francesca","last_name":"Pellicciotti","id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70"}],"oa":1,"_id":"12585","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1038/s41467-021-23073-4","publisher":"Springer Nature","year":"2021","article_type":"original","volume":12,"month":"05","quality_controlled":"1","publication_identifier":{"issn":["2041-1723"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","extern":"1","keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"intvolume":"        12","date_created":"2023-02-20T08:11:29Z","article_number":"2868","oa_version":"Published Version","publication_status":"published","day":"17","abstract":[{"lang":"eng","text":"Glaciers in High Mountain Asia generate meltwater that supports the water needs of 250 million people, but current knowledge of annual accumulation and ablation is limited to sparse field measurements biased in location and glacier size. Here, we present altitudinally-resolved specific mass balances (surface, internal, and basal combined) for 5527 glaciers in High Mountain Asia for 2000–2016, derived by correcting observed glacier thinning patterns for mass redistribution due to ice flow. We find that 41% of glaciers accumulated mass over less than 20% of their area, and only 60% ± 10% of regional annual ablation was compensated by accumulation. Even without 21st century warming, 21% ± 1% of ice volume will be lost by 2100 due to current climatic-geometric imbalance, representing a reduction in glacier ablation into rivers of 28% ± 1%. The ablation of glaciers in the Himalayas and Tien Shan was mostly unsustainable and ice volume in these regions will reduce by at least 30% by 2100. The most important and vulnerable glacier-fed river basins (Amu Darya, Indus, Syr Darya, Tarim Interior) were supplied with >50% sustainable glacier ablation but will see long-term reductions in ice mass and glacier meltwater supply regardless of the Karakoram Anomaly."}],"status":"public","date_updated":"2023-02-28T13:21:51Z","publication":"Nature Communications","title":"Health and sustainability of glaciers in High Mountain Asia","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-021-23073-4"}],"scopus_import":"1","citation":{"ista":"Miles E, McCarthy M, Dehecq A, Kneib M, Fugger S, Pellicciotti F. 2021. Health and sustainability of glaciers in High Mountain Asia. Nature Communications. 12, 2868.","mla":"Miles, Evan, et al. “Health and Sustainability of Glaciers in High Mountain Asia.” <i>Nature Communications</i>, vol. 12, 2868, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41467-021-23073-4\">10.1038/s41467-021-23073-4</a>.","short":"E. Miles, M. McCarthy, A. Dehecq, M. Kneib, S. Fugger, F. Pellicciotti, Nature Communications 12 (2021).","apa":"Miles, E., McCarthy, M., Dehecq, A., Kneib, M., Fugger, S., &#38; Pellicciotti, F. (2021). Health and sustainability of glaciers in High Mountain Asia. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-021-23073-4\">https://doi.org/10.1038/s41467-021-23073-4</a>","ama":"Miles E, McCarthy M, Dehecq A, Kneib M, Fugger S, Pellicciotti F. Health and sustainability of glaciers in High Mountain Asia. <i>Nature Communications</i>. 2021;12. doi:<a href=\"https://doi.org/10.1038/s41467-021-23073-4\">10.1038/s41467-021-23073-4</a>","chicago":"Miles, Evan, Michael McCarthy, Amaury Dehecq, Marin Kneib, Stefan Fugger, and Francesca Pellicciotti. “Health and Sustainability of Glaciers in High Mountain Asia.” <i>Nature Communications</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41467-021-23073-4\">https://doi.org/10.1038/s41467-021-23073-4</a>.","ieee":"E. Miles, M. McCarthy, A. Dehecq, M. Kneib, S. Fugger, and F. Pellicciotti, “Health and sustainability of glaciers in High Mountain Asia,” <i>Nature Communications</i>, vol. 12. Springer Nature, 2021."}},{"_id":"9997","oa":1,"author":[{"full_name":"Schmid, Laura","first_name":"Laura","id":"38B437DE-F248-11E8-B48F-1D18A9856A87","last_name":"Schmid","orcid":"0000-0002-6978-7329"},{"first_name":"Pouya","full_name":"Shati, Pouya","last_name":"Shati"},{"full_name":"Hilbe, Christian","first_name":"Christian","last_name":"Hilbe"},{"full_name":"Chatterjee, Krishnendu","first_name":"Krishnendu","orcid":"0000-0002-4561-241X","last_name":"Chatterjee","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2021-08-31T00:00:00Z","year":"2021","publisher":"Springer Nature","doi":"10.1038/s41598-021-96932-1","language":[{"iso":"eng"}],"type":"journal_article","publication_identifier":{"eissn":["2045-2322"]},"quality_controlled":"1","month":"08","article_type":"original","volume":11,"isi":1,"department":[{"_id":"GradSch"},{"_id":"KrCh"}],"acknowledgement":"This work was supported by the European Research Council CoG 863818 (ForM-SMArt) (to K.C.) and the European Research Council Starting Grant 850529: E-DIRECT (to C.H.). L.S. received additional partial support by the Austrian Science Fund (FWF) under Grant Z211-N23 (Wittgenstein Award).","pmid":1,"date_created":"2021-09-11T16:22:02Z","article_number":"17443","intvolume":"        11","keyword":["Multidisciplinary"],"file_date_updated":"2021-09-13T10:31:21Z","article_processing_charge":"Yes","ddc":["003"],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"lang":"eng","text":"Indirect reciprocity is a mechanism for the evolution of cooperation based on social norms. This mechanism requires that individuals in a population observe and judge each other’s behaviors. Individuals with a good reputation are more likely to receive help from others. Previous work suggests that indirect reciprocity is only effective when all relevant information is reliable and publicly available. Otherwise, individuals may disagree on how to assess others, even if they all apply the same social norm. Such disagreements can lead to a breakdown of cooperation. Here we explore whether the predominantly studied ‘leading eight’ social norms of indirect reciprocity can be made more robust by equipping them with an element of generosity. To this end, we distinguish between two kinds of generosity. According to assessment generosity, individuals occasionally assign a good reputation to group members who would usually be regarded as bad. According to action generosity, individuals occasionally cooperate with group members with whom they would usually defect. Using individual-based simulations, we show that the two kinds of generosity have a very different effect on the resulting reputation dynamics. Assessment generosity tends to add to the overall noise and allows defectors to invade. In contrast, a limited amount of action generosity can be beneficial in a few cases. However, even when action generosity is beneficial, the respective simulations do not result in full cooperation. Our results suggest that while generosity can favor cooperation when individuals use the most simple strategies of reciprocity, it is disadvantageous when individuals use more complex social norms."}],"ec_funded":1,"day":"31","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"oa_version":"Published Version","publication_status":"published","date_updated":"2025-07-14T09:10:09Z","status":"public","file":[{"access_level":"open_access","relation":"main_file","content_type":"application/pdf","creator":"cchlebak","date_created":"2021-09-13T10:31:21Z","checksum":"19df8816cf958b272b85841565c73182","file_id":"10006","date_updated":"2021-09-13T10:31:21Z","success":1,"file_name":"2021_ScientificReports_Schmid.pdf","file_size":2424943}],"title":"The evolution of indirect reciprocity under action and assessment generosity","external_id":{"isi":["000692406400018"],"pmid":["34465830"]},"related_material":{"record":[{"relation":"dissertation_contains","id":"10293","status":"public"}]},"publication":"Scientific Reports","citation":{"ieee":"L. Schmid, P. Shati, C. Hilbe, and K. Chatterjee, “The evolution of indirect reciprocity under action and assessment generosity,” <i>Scientific Reports</i>, vol. 11, no. 1. Springer Nature, 2021.","chicago":"Schmid, Laura, Pouya Shati, Christian Hilbe, and Krishnendu Chatterjee. “The Evolution of Indirect Reciprocity under Action and Assessment Generosity.” <i>Scientific Reports</i>. Springer Nature, 2021. <a href=\"https://doi.org/10.1038/s41598-021-96932-1\">https://doi.org/10.1038/s41598-021-96932-1</a>.","ama":"Schmid L, Shati P, Hilbe C, Chatterjee K. The evolution of indirect reciprocity under action and assessment generosity. <i>Scientific Reports</i>. 2021;11(1). doi:<a href=\"https://doi.org/10.1038/s41598-021-96932-1\">10.1038/s41598-021-96932-1</a>","short":"L. Schmid, P. Shati, C. Hilbe, K. Chatterjee, Scientific Reports 11 (2021).","apa":"Schmid, L., Shati, P., Hilbe, C., &#38; Chatterjee, K. (2021). The evolution of indirect reciprocity under action and assessment generosity. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-021-96932-1\">https://doi.org/10.1038/s41598-021-96932-1</a>","mla":"Schmid, Laura, et al. “The Evolution of Indirect Reciprocity under Action and Assessment Generosity.” <i>Scientific Reports</i>, vol. 11, no. 1, 17443, Springer Nature, 2021, doi:<a href=\"https://doi.org/10.1038/s41598-021-96932-1\">10.1038/s41598-021-96932-1</a>.","ista":"Schmid L, Shati P, Hilbe C, Chatterjee K. 2021. The evolution of indirect reciprocity under action and assessment generosity. Scientific Reports. 11(1), 17443."},"project":[{"grant_number":"863818","call_identifier":"H2020","_id":"0599E47C-7A3F-11EA-A408-12923DDC885E","name":"Formal Methods for Stochastic Models: Algorithms and Applications"},{"grant_number":"Z211","call_identifier":"FWF","_id":"25F42A32-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize"}],"has_accepted_license":"1","issue":"1"},{"citation":{"chicago":"Tsai, Tony Y.-C., Mateusz K Sikora, Peng Xia, Tugba Colak-Champollion, Holger Knaut, Carl-Philipp J Heisenberg, and Sean G. Megason. “An Adhesion Code Ensures Robust Pattern Formation during Tissue Morphogenesis.” <i>Science</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/science.aba6637\">https://doi.org/10.1126/science.aba6637</a>.","ieee":"T. Y.-C. Tsai <i>et al.</i>, “An adhesion code ensures robust pattern formation during tissue morphogenesis,” <i>Science</i>, vol. 370, no. 6512. American Association for the Advancement of Science, pp. 113–116, 2020.","short":"T.Y.-C. Tsai, M.K. Sikora, P. Xia, T. Colak-Champollion, H. Knaut, C.-P.J. Heisenberg, S.G. Megason, Science 370 (2020) 113–116.","apa":"Tsai, T. Y.-C., Sikora, M. K., Xia, P., Colak-Champollion, T., Knaut, H., Heisenberg, C.-P. J., &#38; Megason, S. G. (2020). An adhesion code ensures robust pattern formation during tissue morphogenesis. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aba6637\">https://doi.org/10.1126/science.aba6637</a>","mla":"Tsai, Tony Y. C., et al. “An Adhesion Code Ensures Robust Pattern Formation during Tissue Morphogenesis.” <i>Science</i>, vol. 370, no. 6512, American Association for the Advancement of Science, 2020, pp. 113–16, doi:<a href=\"https://doi.org/10.1126/science.aba6637\">10.1126/science.aba6637</a>.","ista":"Tsai TY-C, Sikora MK, Xia P, Colak-Champollion T, Knaut H, Heisenberg C-PJ, Megason SG. 2020. An adhesion code ensures robust pattern formation during tissue morphogenesis. Science. 370(6512), 113–116.","ama":"Tsai TY-C, Sikora MK, Xia P, et al. An adhesion code ensures robust pattern formation during tissue morphogenesis. <i>Science</i>. 2020;370(6512):113-116. doi:<a href=\"https://doi.org/10.1126/science.aba6637\">10.1126/science.aba6637</a>"},"project":[{"_id":"260F1432-B435-11E9-9278-68D0E5697425","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","grant_number":"742573","call_identifier":"H2020"}],"scopus_import":"1","issue":"6512","main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/803635v1"}],"title":"An adhesion code ensures robust pattern formation during tissue morphogenesis","related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/sticking-together/"}]},"external_id":{"isi":["000579169000053"]},"publication":"Science","date_updated":"2023-08-22T10:36:35Z","status":"public","abstract":[{"text":"Animal development entails the organization of specific cell types in space and time, and spatial patterns must form in a robust manner. In the zebrafish spinal cord, neural progenitors form stereotypic patterns despite noisy morphogen signaling and large-scale cellular rearrangements during morphogenesis and growth. By directly measuring adhesion forces and preferences for three types of endogenous neural progenitors, we provide evidence for the differential adhesion model in which differences in intercellular adhesion mediate cell sorting. Cell type–specific combinatorial expression of different classes of cadherins (N-cadherin, cadherin 11, and protocadherin 19) results in homotypic preference ex vivo and patterning robustness in vivo. Furthermore, the differential adhesion code is regulated by the sonic hedgehog morphogen gradient. We propose that robust patterning during tissue morphogenesis results from interplay between adhesion-based self-organization and morphogen-directed patterning.","lang":"eng"}],"ec_funded":1,"day":"02","publication_status":"published","oa_version":"Preprint","page":"113-116","department":[{"_id":"CaHe"}],"acknowledgement":"We thank the members of the Megason and Heisenberg labs for critical discussions of and technical assistance during the work and B. Appel, S. Holley, J. Jontes, and D. Gilmour for transgenic fish. This work is supported by the Damon Runyon Cancer Foundation, a NICHD K99 fellowship (1K99HD092623), a Travelling Fellowship of the Company of Biologists, a Collaborative Research grant from the Burroughs Wellcome Foundation (T.Y.-C.T.), NIH grant  01GM107733 (T.Y.-C.T. and S.G.M.), NIH grant R01NS102322 (T.C.-C. and H.K.), and an ERC advanced grant\r\n(MECSPEC) (C.-P.H.).","date_created":"2020-10-19T14:09:38Z","intvolume":"       370","keyword":["Multidisciplinary"],"article_processing_charge":"No","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"quality_controlled":"1","month":"10","volume":370,"article_type":"original","isi":1,"year":"2020","publisher":"American Association for the Advancement of Science","doi":"10.1126/science.aba6637","language":[{"iso":"eng"}],"type":"journal_article","_id":"8680","oa":1,"author":[{"last_name":"Tsai","first_name":"Tony Y.-C.","full_name":"Tsai, Tony Y.-C."},{"last_name":"Sikora","id":"2F74BCDE-F248-11E8-B48F-1D18A9856A87","full_name":"Sikora, Mateusz K","first_name":"Mateusz K"},{"full_name":"Xia, Peng","first_name":"Peng","id":"4AB6C7D0-F248-11E8-B48F-1D18A9856A87","last_name":"Xia","orcid":"0000-0002-5419-7756"},{"full_name":"Colak-Champollion, Tugba","first_name":"Tugba","last_name":"Colak-Champollion"},{"first_name":"Holger","full_name":"Knaut, Holger","last_name":"Knaut"},{"orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J"},{"last_name":"Megason","first_name":"Sean G.","full_name":"Megason, Sean G."}],"date_published":"2020-10-02T00:00:00Z"},{"status":"public","date_updated":"2023-02-23T13:47:55Z","abstract":[{"text":"From rock salt to nanoparticle superlattices, complex structure can emerge from simple building blocks that attract each other through Coulombic forces1-4. On the micrometre scale, however, colloids in water defy the intuitively simple idea of forming crystals from oppositely charged partners, instead forming non-equilibrium structures such as clusters and gels5-7. Although various systems have been engineered to grow binary crystals8-11, native surface charge in aqueous conditions has not been used to assemble crystalline materials. Here we form ionic colloidal crystals in water through an approach that we refer to as polymer-attenuated Coulombic self-assembly. The key to crystallization is the use of a neutral polymer to keep particles separated by well defined distances, allowing us to tune the attractive overlap of electrical double layers, directing particles to disperse, crystallize or become permanently fixed on demand. The nucleation and growth of macroscopic single crystals is demonstrated by using the Debye screening length to fine-tune assembly. Using a variety of colloidal particles and commercial polymers, ionic colloidal crystals isostructural to caesium chloride, sodium chloride, aluminium diboride and K4C60 are selected according to particle size ratios. Once fixed by simply diluting out solution salts, crystals are pulled out of the water for further manipulation, demonstrating an accurate translation from solution-phase assembly to dried solid structures. In contrast to other assembly approaches, in which particles must be carefully engineered to encode binding information12-18, polymer-attenuated Coulombic self-assembly enables conventional colloids to be used as model colloidal ions, primed for crystallization. ","lang":"eng"}],"day":"23","publication_status":"published","oa_version":"None","page":"487-490","scopus_import":"1","issue":"7804","citation":{"ieee":"T. Hueckel, G. M. Hocky, J. A. Palacci, and S. Sacanna, “Ionic solids from common colloids,” <i>Nature</i>, vol. 580, no. 7804. Springer Nature, pp. 487–490, 2020.","chicago":"Hueckel, Theodore, Glen M. Hocky, Jérémie A Palacci, and Stefano Sacanna. “Ionic Solids from Common Colloids.” <i>Nature</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41586-020-2205-0\">https://doi.org/10.1038/s41586-020-2205-0</a>.","ama":"Hueckel T, Hocky GM, Palacci JA, Sacanna S. Ionic solids from common colloids. <i>Nature</i>. 2020;580(7804):487-490. doi:<a href=\"https://doi.org/10.1038/s41586-020-2205-0\">10.1038/s41586-020-2205-0</a>","apa":"Hueckel, T., Hocky, G. M., Palacci, J. A., &#38; Sacanna, S. (2020). Ionic solids from common colloids. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-020-2205-0\">https://doi.org/10.1038/s41586-020-2205-0</a>","ista":"Hueckel T, Hocky GM, Palacci JA, Sacanna S. 2020. Ionic solids from common colloids. Nature. 580(7804), 487–490.","short":"T. Hueckel, G.M. Hocky, J.A. Palacci, S. Sacanna, Nature 580 (2020) 487–490.","mla":"Hueckel, Theodore, et al. “Ionic Solids from Common Colloids.” <i>Nature</i>, vol. 580, no. 7804, Springer Nature, 2020, pp. 487–90, doi:<a href=\"https://doi.org/10.1038/s41586-020-2205-0\">10.1038/s41586-020-2205-0</a>."},"title":"Ionic solids from common colloids","external_id":{"pmid":["32322078"]},"publication":"Nature","type":"journal_article","year":"2020","publisher":"Springer Nature","doi":"10.1038/s41586-020-2205-0","language":[{"iso":"eng"}],"date_published":"2020-04-23T00:00:00Z","_id":"9059","author":[{"last_name":"Hueckel","full_name":"Hueckel, Theodore","first_name":"Theodore"},{"last_name":"Hocky","first_name":"Glen M.","full_name":"Hocky, Glen M."},{"full_name":"Palacci, Jérémie A","first_name":"Jérémie A","last_name":"Palacci","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","orcid":"0000-0002-7253-9465"},{"first_name":"Stefano","full_name":"Sacanna, Stefano","last_name":"Sacanna"}],"intvolume":"       580","keyword":["Multidisciplinary"],"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","extern":"1","article_processing_charge":"No","pmid":1,"date_created":"2021-02-02T13:30:50Z","article_type":"original","volume":580,"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"quality_controlled":"1","month":"04"},{"publication":"Science Advances","file":[{"creator":"cchlebak","relation":"main_file","content_type":"application/pdf","access_level":"open_access","file_size":10381298,"file_name":"2020_SciAdv_Tian.pdf","date_updated":"2021-11-26T06:50:09Z","success":1,"file_id":"10343","checksum":"3ba2eca975930cdb0b1ce1ae876885a7","date_created":"2021-11-26T06:50:09Z"}],"title":"On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias","external_id":{"pmid":["33246953"]},"main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.04.04.025866v1","open_access":"1"}],"scopus_import":"1","issue":"48","has_accepted_license":"1","citation":{"ieee":"X. Tian <i>et al.</i>, “On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias,” <i>Science Advances</i>, vol. 6, no. 48. American Association for the Advancement of Science, 2020.","chicago":"Tian, Xiaohe, Diana M. Leite, Edoardo Scarpa, Sophie Nyberg, Gavin Fullstone, Joe Forth, Diana Matias, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” <i>Science Advances</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/sciadv.abc4397\">https://doi.org/10.1126/sciadv.abc4397</a>.","ama":"Tian X, Leite DM, Scarpa E, et al. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. <i>Science Advances</i>. 2020;6(48). doi:<a href=\"https://doi.org/10.1126/sciadv.abc4397\">10.1126/sciadv.abc4397</a>","short":"X. Tian, D.M. Leite, E. Scarpa, S. Nyberg, G. Fullstone, J. Forth, D. Matias, A. Apriceno, A. Poma, A. Duro-Castano, M. Vuyyuru, L. Harker-Kirschneck, A. Šarić, Z. Zhang, P. Xiang, B. Fang, Y. Tian, L. Luo, L. Rizzello, G. Battaglia, Science Advances 6 (2020).","mla":"Tian, Xiaohe, et al. “On the Shuttling across the Blood-Brain Barrier via Tubule Formation: Mechanism and Cargo Avidity Bias.” <i>Science Advances</i>, vol. 6, no. 48, eabc4397, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/sciadv.abc4397\">10.1126/sciadv.abc4397</a>.","ista":"Tian X, Leite DM, Scarpa E, Nyberg S, Fullstone G, Forth J, Matias D, Apriceno A, Poma A, Duro-Castano A, Vuyyuru M, Harker-Kirschneck L, Šarić A, Zhang Z, Xiang P, Fang B, Tian Y, Luo L, Rizzello L, Battaglia G. 2020. On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. Science Advances. 6(48), eabc4397.","apa":"Tian, X., Leite, D. M., Scarpa, E., Nyberg, S., Fullstone, G., Forth, J., … Battaglia, G. (2020). On the shuttling across the blood-brain barrier via tubule formation: Mechanism and cargo avidity bias. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.abc4397\">https://doi.org/10.1126/sciadv.abc4397</a>"},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"day":"27","publication_status":"published","oa_version":"Published Version","abstract":[{"text":"The blood-brain barrier is made of polarized brain endothelial cells (BECs) phenotypically conditioned by the central nervous system (CNS). Although transport across BECs is of paramount importance for nutrient uptake as well as ridding the brain of waste products, the intracellular sorting mechanisms that regulate successful receptor-mediated transcytosis in BECs remain to be elucidated. Here, we used a synthetic multivalent system with tunable avidity to the low-density lipoprotein receptor–related protein 1 (LRP1) to investigate the mechanisms of transport across BECs. We used a combination of conventional and super-resolution microscopy, both in vivo and in vitro, accompanied with biophysical modeling of transport kinetics and membrane-bound interactions to elucidate the role of membrane-sculpting protein syndapin-2 on fast transport via tubule formation. We show that high-avidity cargo biases the LRP1 toward internalization associated with fast degradation, while mid-avidity augments the formation of syndapin-2 tubular carriers promoting a fast shuttling across.","lang":"eng"}],"status":"public","date_updated":"2021-11-26T07:00:24Z","article_type":"original","volume":6,"month":"11","publication_identifier":{"issn":["2375-2548"]},"quality_controlled":"1","file_date_updated":"2021-11-26T06:50:09Z","ddc":["611"],"article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","extern":"1","intvolume":"         6","keyword":["multidisciplinary"],"article_number":"eabc4397 ","date_created":"2021-11-26T06:40:28Z","acknowledgement":"Funding: G.B. thanks the ERC for the starting grant (MEViC 278793) and consolidator award (CheSSTaG 769798), EPSRC/BTG Healthcare Partnership (EP/I001697/1), EPSRC Established Career Fellowship (EP/N026322/1), EPSRC/SomaNautix Healthcare Partnership EP/R024723/1, and Children with Cancer UK for the research project (16-227). X.T. and G.B. thank that Anhui 100 Talent program for facilitating data sharing and research visits. A.D.-C. and L.R. acknowledge the Royal Society for a Newton fellowship and the Marie Skłodowska-Curie Actions for a European Fellowship. Author contributions: X.T. prepared and characterized POs, performed all the fast imaging in both conventional and STED microscopy, set up the initial BBB model, encapsulated the PtA2 in POs, and supervised the PtA2-PO animal work. D.M.L. prepared and characterized POs; performed all the permeability studies, PLA assays, WB and associated data analysis, and part of the colocalization assays; and performed experiments with the shRNA for knockdown of syndapin-2. E.S. prepared and characterized POs and performed part of colocalization assays and Cy7-labeled PO animal experiments. S.N. prepared and characterized POs and performed part of the colocalization and inhibition assays. G.F. designed, performed, and analyzed the agent-based simulations of transcytosis. J.F. designed the image-based algorithm to analyze the PLA data. D.M. prepared and characterized POs and helped with Cy7-labeled PO animal experiments. A.A. performed TEM imaging of the POs. A.P. and A.D.-C. synthesized the dye- and peptide-functionalized and pristine copolymers. M.V., L.H.-K., and A.Š. designed, performed, and analyzed the MD simulations. Z.Z. supervised and supported STED imaging. P.X., B.F., and Y.T. synthesized and characterized the PtA2 compound. L.L. performed some of the animal work. L.R. supported and helped with the BBB characterization. G.B. analyzed all fast imaging and supervised and coordinated the overall work. X.T., D.M.L., E.S., and G.B. wrote the manuscript. Competing interests: The authors declare that part of the work is associated with the UCL spin-out company SomaNautix Ltd. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials. Additional data related to this paper may be requested from the authors.","pmid":1,"date_published":"2020-11-27T00:00:00Z","author":[{"last_name":"Tian","full_name":"Tian, Xiaohe","first_name":"Xiaohe"},{"last_name":"Leite","first_name":"Diana M.","full_name":"Leite, Diana M."},{"last_name":"Scarpa","first_name":"Edoardo","full_name":"Scarpa, Edoardo"},{"full_name":"Nyberg, Sophie","first_name":"Sophie","last_name":"Nyberg"},{"last_name":"Fullstone","first_name":"Gavin","full_name":"Fullstone, Gavin"},{"last_name":"Forth","first_name":"Joe","full_name":"Forth, Joe"},{"last_name":"Matias","full_name":"Matias, Diana","first_name":"Diana"},{"last_name":"Apriceno","first_name":"Azzurra","full_name":"Apriceno, Azzurra"},{"last_name":"Poma","full_name":"Poma, Alessandro","first_name":"Alessandro"},{"last_name":"Duro-Castano","full_name":"Duro-Castano, Aroa","first_name":"Aroa"},{"full_name":"Vuyyuru, Manish","first_name":"Manish","last_name":"Vuyyuru"},{"first_name":"Lena","full_name":"Harker-Kirschneck, Lena","last_name":"Harker-Kirschneck"},{"full_name":"Šarić, Anđela","first_name":"Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","last_name":"Šarić","orcid":"0000-0002-7854-2139"},{"last_name":"Zhang","full_name":"Zhang, Zhongping","first_name":"Zhongping"},{"first_name":"Pan","full_name":"Xiang, Pan","last_name":"Xiang"},{"first_name":"Bin","full_name":"Fang, Bin","last_name":"Fang"},{"first_name":"Yupeng","full_name":"Tian, Yupeng","last_name":"Tian"},{"first_name":"Lei","full_name":"Luo, Lei","last_name":"Luo"},{"first_name":"Loris","full_name":"Rizzello, Loris","last_name":"Rizzello"},{"full_name":"Battaglia, Giuseppe","first_name":"Giuseppe","last_name":"Battaglia"}],"_id":"10342","oa":1,"type":"journal_article","doi":"10.1126/sciadv.abc4397","language":[{"iso":"eng"}],"year":"2020","publisher":"American Association for the Advancement of Science"},{"date_created":"2021-11-26T07:48:27Z","acknowledgement":"We acknowledge support from Peterhouse, Cambridge (T.C.T.M.); the Swiss National Science Foundation (T.C.T.M.); the Royal Society (A.S. and S.C.); the Academy of Medical Sciences (A.S.); Sidney Sussex College, Cambridge (G.M.); Newnham College, Cambridge (G.T.H.); the Wellcome Trust (T.P.J.K.); the Cambridge Center for Misfolding Diseases (T.P.J.K. and M.V.); the Biotechnology and Biological Sciences Research Council (T.P.J.K.); the Frances and Augustus Newman Foundation (T.P.J.K.); and the Synapsis Foundation for Alzheimer’s disease (P.A.). The research leading to these results has received funding from the European Research Council (ERC) under the European Union’s Seventh Framework Program (FP7/2007-2013) through the ERC Grant PhysProt (Agreement 337969).","pmid":1,"article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","extern":"1","intvolume":"       117","keyword":["multidisciplinary"],"month":"09","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"quality_controlled":"1","volume":117,"article_type":"original","doi":"10.1073/pnas.2006684117","language":[{"iso":"eng"}],"year":"2020","publisher":"National Academy of Sciences","type":"journal_article","author":[{"first_name":"Thomas C. T.","full_name":"Michaels, Thomas C. T.","last_name":"Michaels"},{"id":"bf63d406-f056-11eb-b41d-f263a6566d8b","last_name":"Šarić","orcid":"0000-0002-7854-2139","first_name":"Anđela","full_name":"Šarić, Anđela"},{"last_name":"Meisl","first_name":"Georg","full_name":"Meisl, Georg"},{"last_name":"Heller","first_name":"Gabriella T.","full_name":"Heller, Gabriella T."},{"last_name":"Curk","first_name":"Samo","full_name":"Curk, Samo"},{"last_name":"Arosio","full_name":"Arosio, Paolo","first_name":"Paolo"},{"first_name":"Sara","full_name":"Linse, Sara","last_name":"Linse"},{"last_name":"Dobson","full_name":"Dobson, Christopher M.","first_name":"Christopher M."},{"last_name":"Vendruscolo","full_name":"Vendruscolo, Michele","first_name":"Michele"},{"last_name":"Knowles","first_name":"Tuomas P. J.","full_name":"Knowles, Tuomas P. J."}],"_id":"10347","oa":1,"date_published":"2020-09-14T00:00:00Z","citation":{"ieee":"T. C. T. Michaels <i>et al.</i>, “Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors,” <i>Proceedings of the National Academy of Sciences</i>, vol. 117, no. 39. National Academy of Sciences, pp. 24251–24257, 2020.","chicago":"Michaels, Thomas C. T., Anđela Šarić, Georg Meisl, Gabriella T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher M. Dobson, Michele Vendruscolo, and Tuomas P. J. Knowles. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation Inhibitors.” <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences, 2020. <a href=\"https://doi.org/10.1073/pnas.2006684117\">https://doi.org/10.1073/pnas.2006684117</a>.","ama":"Michaels TCT, Šarić A, Meisl G, et al. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. <i>Proceedings of the National Academy of Sciences</i>. 2020;117(39):24251-24257. doi:<a href=\"https://doi.org/10.1073/pnas.2006684117\">10.1073/pnas.2006684117</a>","short":"T.C.T. Michaels, A. Šarić, G. Meisl, G.T. Heller, S. Curk, P. Arosio, S. Linse, C.M. Dobson, M. Vendruscolo, T.P.J. Knowles, Proceedings of the National Academy of Sciences 117 (2020) 24251–24257.","mla":"Michaels, Thomas C. T., et al. “Thermodynamic and Kinetic Design Principles for Amyloid-Aggregation Inhibitors.” <i>Proceedings of the National Academy of Sciences</i>, vol. 117, no. 39, National Academy of Sciences, 2020, pp. 24251–57, doi:<a href=\"https://doi.org/10.1073/pnas.2006684117\">10.1073/pnas.2006684117</a>.","apa":"Michaels, T. C. T., Šarić, A., Meisl, G., Heller, G. T., Curk, S., Arosio, P., … Knowles, T. P. J. (2020). Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2006684117\">https://doi.org/10.1073/pnas.2006684117</a>","ista":"Michaels TCT, Šarić A, Meisl G, Heller GT, Curk S, Arosio P, Linse S, Dobson CM, Vendruscolo M, Knowles TPJ. 2020. Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors. Proceedings of the National Academy of Sciences. 117(39), 24251–24257."},"scopus_import":"1","issue":"39","main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/2020.02.22.960716","open_access":"1"}],"publication":"Proceedings of the National Academy of Sciences","title":"Thermodynamic and kinetic design principles for amyloid-aggregation inhibitors","external_id":{"pmid":["32929030"]},"date_updated":"2021-11-26T08:59:06Z","status":"public","day":"14","page":"24251-24257","publication_status":"published","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Understanding the mechanism of action of compounds capable of inhibiting amyloid-fibril formation is critical to the development of potential therapeutics against protein-misfolding diseases. A fundamental challenge for progress is the range of possible target species and the disparate timescales involved, since the aggregating proteins are simultaneously the reactants, products, intermediates, and catalysts of the reaction. It is a complex problem, therefore, to choose the states of the aggregating proteins that should be bound by the compounds to achieve the most potent inhibition. We present here a comprehensive kinetic theory of amyloid-aggregation inhibition that reveals the fundamental thermodynamic and kinetic signatures characterizing effective inhibitors by identifying quantitative relationships between the aggregation and binding rate constants. These results provide general physical laws to guide the design and optimization of inhibitors of amyloid-fibril formation, revealing in particular the important role of on-rates in the binding of the inhibitors."}]},{"date_published":"2020-08-07T00:00:00Z","author":[{"last_name":"Tarrason Risa","full_name":"Tarrason Risa, Gabriel","first_name":"Gabriel"},{"last_name":"Hurtig","full_name":"Hurtig, Fredrik","first_name":"Fredrik"},{"last_name":"Bray","full_name":"Bray, Sian","first_name":"Sian"},{"full_name":"Hafner, Anne E.","first_name":"Anne E.","last_name":"Hafner"},{"first_name":"Lena","full_name":"Harker-Kirschneck, Lena","last_name":"Harker-Kirschneck"},{"first_name":"Peter","full_name":"Faull, Peter","last_name":"Faull"},{"last_name":"Davis","full_name":"Davis, Colin","first_name":"Colin"},{"first_name":"Dimitra","full_name":"Papatziamou, Dimitra","last_name":"Papatziamou"},{"full_name":"Mutavchiev, Delyan R.","first_name":"Delyan R.","last_name":"Mutavchiev"},{"last_name":"Fan","first_name":"Catherine","full_name":"Fan, Catherine"},{"first_name":"Leticia","full_name":"Meneguello, Leticia","last_name":"Meneguello"},{"full_name":"Arashiro Pulschen, Andre","first_name":"Andre","last_name":"Arashiro Pulschen"},{"first_name":"Gautam","full_name":"Dey, Gautam","last_name":"Dey"},{"first_name":"Siân","full_name":"Culley, Siân","last_name":"Culley"},{"full_name":"Kilkenny, Mairi","first_name":"Mairi","last_name":"Kilkenny"},{"full_name":"Souza, Diorge P.","first_name":"Diorge P.","last_name":"Souza"},{"full_name":"Pellegrini, Luca","first_name":"Luca","last_name":"Pellegrini"},{"first_name":"Robertus A. M.","full_name":"de Bruin, Robertus A. M.","last_name":"de Bruin"},{"first_name":"Ricardo","full_name":"Henriques, Ricardo","last_name":"Henriques"},{"last_name":"Snijders","full_name":"Snijders, Ambrosius P.","first_name":"Ambrosius P."},{"last_name":"Šarić","id":"bf63d406-f056-11eb-b41d-f263a6566d8b","orcid":"0000-0002-7854-2139","full_name":"Šarić, Anđela","first_name":"Anđela"},{"last_name":"Lindås","full_name":"Lindås, Ann-Christin","first_name":"Ann-Christin"},{"last_name":"Robinson","first_name":"Nicholas P.","full_name":"Robinson, Nicholas P."},{"full_name":"Baum, Buzz","first_name":"Buzz","last_name":"Baum"}],"_id":"10349","oa":1,"type":"journal_article","doi":"10.1126/science.aaz2532","language":[{"iso":"eng"}],"year":"2020","publisher":"American Association for the Advancement of Science","volume":369,"article_type":"original","month":"08","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"quality_controlled":"1","extern":"1","article_processing_charge":"No","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","intvolume":"       369","keyword":["multidisciplinary"],"date_created":"2021-11-26T08:21:34Z","acknowledgement":"We thank the MRC LMCB at UCL for their support; the flow cytometry STP at the Francis Crick Institute for assistance, with special thanks to S. Purewal and D. Davis; C. Bertoli for mentorship\r\nand advice; J. M. Garcia-Arcos for help early on in this project; the entire Baum lab for their input throughout the project; the Albers lab for advice and reagents, with special thanks to M. Van Wolferen and S. Albers; the members of the Wellcome consortium for archaeal cytoskeleton studies for advice and comments; and J. Löwe, S. Oliferenko, M. Balasubramanian, and D. Gerlich for discussions and advice on the manuscript. N.P.R. and S.B. would like to thank N. Rzechorzek, A. Simon, and S. Anjum for discussion and advice.","pmid":1,"day":"07","oa_version":"Preprint","publication_status":"published","abstract":[{"text":"Sulfolobus acidocaldarius is the closest experimentally tractable archaeal relative of eukaryotes and, despite lacking obvious cyclin-dependent kinase and cyclin homologs, has an ordered eukaryote-like cell cycle with distinct phases of DNA replication and division. Here, in exploring the mechanism of cell division in S. acidocaldarius, we identify a role for the archaeal proteasome in regulating the transition from the end of one cell cycle to the beginning of the next. Further, we identify the archaeal ESCRT-III homolog, CdvB, as a key target of the proteasome and show that its degradation triggers division by allowing constriction of the CdvB1:CdvB2 ESCRT-III division ring. These findings offer a minimal mechanism for ESCRT-III–mediated membrane remodeling and point to a conserved role for the proteasome in eukaryotic and archaeal cell cycle control.","lang":"eng"}],"status":"public","date_updated":"2021-11-26T08:58:33Z","publication":"Science","title":"The proteasome controls ESCRT-III–mediated cell division in an archaeon","external_id":{"pmid":["32764038"]},"main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/774273v1"}],"scopus_import":"1","issue":"6504","citation":{"chicago":"Tarrason Risa, Gabriel, Fredrik Hurtig, Sian Bray, Anne E. Hafner, Lena Harker-Kirschneck, Peter Faull, Colin Davis, et al. “The Proteasome Controls ESCRT-III–Mediated Cell Division in an Archaeon.” <i>Science</i>. American Association for the Advancement of Science, 2020. <a href=\"https://doi.org/10.1126/science.aaz2532\">https://doi.org/10.1126/science.aaz2532</a>.","ieee":"G. Tarrason Risa <i>et al.</i>, “The proteasome controls ESCRT-III–mediated cell division in an archaeon,” <i>Science</i>, vol. 369, no. 6504. American Association for the Advancement of Science, 2020.","short":"G. Tarrason Risa, F. Hurtig, S. Bray, A.E. Hafner, L. Harker-Kirschneck, P. Faull, C. Davis, D. Papatziamou, D.R. Mutavchiev, C. Fan, L. Meneguello, A. Arashiro Pulschen, G. Dey, S. Culley, M. Kilkenny, D.P. Souza, L. Pellegrini, R.A.M. de Bruin, R. Henriques, A.P. Snijders, A. Šarić, A.-C. Lindås, N.P. Robinson, B. Baum, Science 369 (2020).","apa":"Tarrason Risa, G., Hurtig, F., Bray, S., Hafner, A. E., Harker-Kirschneck, L., Faull, P., … Baum, B. (2020). The proteasome controls ESCRT-III–mediated cell division in an archaeon. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aaz2532\">https://doi.org/10.1126/science.aaz2532</a>","mla":"Tarrason Risa, Gabriel, et al. “The Proteasome Controls ESCRT-III–Mediated Cell Division in an Archaeon.” <i>Science</i>, vol. 369, no. 6504, American Association for the Advancement of Science, 2020, doi:<a href=\"https://doi.org/10.1126/science.aaz2532\">10.1126/science.aaz2532</a>.","ista":"Tarrason Risa G, Hurtig F, Bray S, Hafner AE, Harker-Kirschneck L, Faull P, Davis C, Papatziamou D, Mutavchiev DR, Fan C, Meneguello L, Arashiro Pulschen A, Dey G, Culley S, Kilkenny M, Souza DP, Pellegrini L, de Bruin RAM, Henriques R, Snijders AP, Šarić A, Lindås A-C, Robinson NP, Baum B. 2020. The proteasome controls ESCRT-III–mediated cell division in an archaeon. Science. 369(6504).","ama":"Tarrason Risa G, Hurtig F, Bray S, et al. The proteasome controls ESCRT-III–mediated cell division in an archaeon. <i>Science</i>. 2020;369(6504). doi:<a href=\"https://doi.org/10.1126/science.aaz2532\">10.1126/science.aaz2532</a>"}},{"publication":"Nature","title":"Electrical switching of magnetic order in an orbital Chern insulator","external_id":{"pmid":["33230333"],"arxiv":["2004.11353"]},"main_file_link":[{"url":"https://arxiv.org/abs/2004.11353","open_access":"1"}],"scopus_import":"1","issue":"7836","arxiv":1,"citation":{"ama":"Polshyn H, Zhu J, Kumar MA, et al. Electrical switching of magnetic order in an orbital Chern insulator. <i>Nature</i>. 2020;588(7836):66-70. doi:<a href=\"https://doi.org/10.1038/s41586-020-2963-8\">10.1038/s41586-020-2963-8</a>","mla":"Polshyn, Hryhoriy, et al. “Electrical Switching of Magnetic Order in an Orbital Chern Insulator.” <i>Nature</i>, vol. 588, no. 7836, Springer Nature, 2020, pp. 66–70, doi:<a href=\"https://doi.org/10.1038/s41586-020-2963-8\">10.1038/s41586-020-2963-8</a>.","apa":"Polshyn, H., Zhu, J., Kumar, M. A., Zhang, Y., Yang, F., Tschirhart, C. L., … Young, A. F. (2020). Electrical switching of magnetic order in an orbital Chern insulator. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-020-2963-8\">https://doi.org/10.1038/s41586-020-2963-8</a>","short":"H. Polshyn, J. Zhu, M.A. Kumar, Y. Zhang, F. Yang, C.L. Tschirhart, M. Serlin, K. Watanabe, T. Taniguchi, A.H. MacDonald, A.F. Young, Nature 588 (2020) 66–70.","ista":"Polshyn H, Zhu J, Kumar MA, Zhang Y, Yang F, Tschirhart CL, Serlin M, Watanabe K, Taniguchi T, MacDonald AH, Young AF. 2020. Electrical switching of magnetic order in an orbital Chern insulator. Nature. 588(7836), 66–70.","ieee":"H. Polshyn <i>et al.</i>, “Electrical switching of magnetic order in an orbital Chern insulator,” <i>Nature</i>, vol. 588, no. 7836. Springer Nature, pp. 66–70, 2020.","chicago":"Polshyn, Hryhoriy, J. Zhu, M. A. Kumar, Y. Zhang, F. Yang, C. L. Tschirhart, M. Serlin, et al. “Electrical Switching of Magnetic Order in an Orbital Chern Insulator.” <i>Nature</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41586-020-2963-8\">https://doi.org/10.1038/s41586-020-2963-8</a>."},"day":"23","page":"66-70","oa_version":"Preprint","publication_status":"published","abstract":[{"text":"Magnetism typically arises from the joint effect of Fermi statistics and repulsive Coulomb interactions, which favours ground states with non-zero electron spin. As a result, controlling spin magnetism with electric fields—a longstanding technological goal in spintronics and multiferroics1,2—can be achieved only indirectly. Here we experimentally demonstrate direct electric-field control of magnetic states in an orbital Chern insulator3,4,5,6, a magnetic system in which non-trivial band topology favours long-range order of orbital angular momentum but the spins are thought to remain disordered7,8,9,10,11,12,13,14. We use van der Waals heterostructures consisting of a graphene monolayer rotationally faulted with respect to a Bernal-stacked bilayer to realize narrow and topologically non-trivial valley-projected moiré minibands15,16,17. At fillings of one and three electrons per moiré unit cell within these bands, we observe quantized anomalous Hall effects18 with transverse resistance approximately equal to h/2e2 (where h is Planck’s constant and e is the charge on the electron), which is indicative of spontaneous polarization of the system into a single-valley-projected band with a Chern number equal to two. At a filling of three electrons per moiré unit cell, we find that the sign of the quantum anomalous Hall effect can be reversed via field-effect control of the chemical potential; moreover, this transition is hysteretic, which we use to demonstrate non-volatile electric-field-induced reversal of the magnetic state. A theoretical analysis19 indicates that the effect arises from the topological edge states, which drive a change in sign of the magnetization and thus a reversal in the favoured magnetic state. Voltage control of magnetic states can be used to electrically pattern non-volatile magnetic-domain structures hosting chiral edge states, with applications ranging from reconfigurable microwave circuit elements to ultralow-power magnetic memories.","lang":"eng"}],"status":"public","date_updated":"2022-01-13T14:21:04Z","volume":588,"article_type":"original","month":"11","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"quality_controlled":"1","extern":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","intvolume":"       588","keyword":["multidisciplinary"],"date_created":"2022-01-13T14:12:17Z","acknowledgement":"We acknowledge discussions with J. Checkelsky, S. Chen, C. Dean, M. Yankowitz, D. Reilly, I. Sodemann and M. Zaletel. Work at UCSB was primarily supported by the ARO under MURI W911NF-16-1-0361. Measurements of twisted bilayer graphene (Extended Data Fig. 8) and measurements at elevated temperatures (Extended Data Fig. 3) were supported by a SEED grant and made use of shared facilities of the UCSB MRSEC (NSF DMR 1720256), a member of the Materials Research Facilities Network (www.mrfn.org). A.F.Y. acknowledges the support of the David and Lucille Packard Foundation under award 2016-65145. A.H.M. and J.Z. were supported by the National Science Foundation through the Center for Dynamics and Control of Materials, an NSF MRSEC under Cooperative Agreement number DMR-1720595, and by the Welch Foundation under grant TBF1473. C.L.T. acknowledges support from the Hertz Foundation and from the National Science Foundation Graduate Research Fellowship Program under grant 1650114. K.W. and T.T. acknowledge support from the Elemental Strategy Initiative conducted by the MEXT, Japan, Grant Number JPMXP0112101001, JSPS KAKENHI grant numbers JP20H00354 and the CREST(JPMJCR15F3), JST.","pmid":1,"date_published":"2020-11-23T00:00:00Z","author":[{"last_name":"Polshyn","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","orcid":"0000-0001-8223-8896","full_name":"Polshyn, Hryhoriy","first_name":"Hryhoriy"},{"first_name":"J.","full_name":"Zhu, J.","last_name":"Zhu"},{"full_name":"Kumar, M. A.","first_name":"M. A.","last_name":"Kumar"},{"last_name":"Zhang","first_name":"Y.","full_name":"Zhang, Y."},{"full_name":"Yang, F.","first_name":"F.","last_name":"Yang"},{"full_name":"Tschirhart, C. L.","first_name":"C. L.","last_name":"Tschirhart"},{"last_name":"Serlin","full_name":"Serlin, M.","first_name":"M."},{"first_name":"K.","full_name":"Watanabe, K.","last_name":"Watanabe"},{"last_name":"Taniguchi","full_name":"Taniguchi, T.","first_name":"T."},{"last_name":"MacDonald","first_name":"A. H.","full_name":"MacDonald, A. H."},{"last_name":"Young","full_name":"Young, A. F.","first_name":"A. F."}],"_id":"10618","oa":1,"type":"journal_article","doi":"10.1038/s41586-020-2963-8","language":[{"iso":"eng"}],"year":"2020","publisher":"Springer Nature"},{"status":"public","date_updated":"2023-05-08T10:53:55Z","page":"16660-16666","oa_version":"Published Version","publication_status":"published","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"day":"22","abstract":[{"lang":"eng","text":"Molecular mechanisms enabling the switching and maintenance of epigenetic states are not fully understood. Distinct histone modifications are often associated with ON/OFF epigenetic states, but how these states are stably maintained through DNA replication, yet in certain situations switch from one to another remains unclear. Here, we address this problem through identification of Arabidopsis INCURVATA11 (ICU11) as a Polycomb Repressive Complex 2 accessory protein. ICU11 robustly immunoprecipitated in vivo with PRC2 core components and the accessory proteins, EMBRYONIC FLOWER 1 (EMF1), LIKE HETEROCHROMATIN PROTEIN1 (LHP1), and TELOMERE_REPEAT_BINDING FACTORS (TRBs). ICU11 encodes a 2-oxoglutarate-dependent dioxygenase, an activity associated with histone demethylation in other organisms, and mutant plants show defects in multiple aspects of the Arabidopsis epigenome. To investigate its primary molecular function we identified the Arabidopsis FLOWERING LOCUS C (FLC) as a direct target and found icu11 disrupted the cold-induced, Polycomb-mediated silencing underlying vernalization. icu11 prevented reduction in H3K36me3 levels normally seen during the early cold phase, supporting a role for ICU11 in H3K36me3 demethylation. This was coincident with an attenuation of H3K27me3 at the internal nucleation site in FLC, and reduction in H3K27me3 levels across the body of the gene after plants were returned to the warm. Thus, ICU11 is required for the cold-induced epigenetic switching between the mutually exclusive chromatin states at FLC, from the active H3K36me3 state to the silenced H3K27me3 state. These data support the importance of physical coupling of histone modification activities to promote epigenetic switching between opposing chromatin states."}],"issue":"28","scopus_import":"1","has_accepted_license":"1","citation":{"ama":"Bloomer RH, Hutchison CE, Bäurle I, et al. The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2. <i>Proceedings of the National Academy of Sciences</i>. 2020;117(28):16660-16666. doi:<a href=\"https://doi.org/10.1073/pnas.1920621117\">10.1073/pnas.1920621117</a>","apa":"Bloomer, R. H., Hutchison, C. E., Bäurle, I., Walker, J., Fang, X., Perera, P., … Dean, C. (2020). The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2. <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1920621117\">https://doi.org/10.1073/pnas.1920621117</a>","short":"R.H. Bloomer, C.E. Hutchison, I. Bäurle, J. Walker, X. Fang, P. Perera, C.N. Velanis, S. Gümüs, C. Spanos, J. Rappsilber, X. Feng, J. Goodrich, C. Dean, Proceedings of the National Academy of Sciences 117 (2020) 16660–16666.","ista":"Bloomer RH, Hutchison CE, Bäurle I, Walker J, Fang X, Perera P, Velanis CN, Gümüs S, Spanos C, Rappsilber J, Feng X, Goodrich J, Dean C. 2020. The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2. Proceedings of the National Academy of Sciences. 117(28), 16660–16666.","mla":"Bloomer, Rebecca H., et al. “The  Arabidopsis Epigenetic Regulator ICU11 as an Accessory Protein of Polycomb Repressive Complex 2.” <i>Proceedings of the National Academy of Sciences</i>, vol. 117, no. 28, Proceedings of the National Academy of Sciences, 2020, pp. 16660–66, doi:<a href=\"https://doi.org/10.1073/pnas.1920621117\">10.1073/pnas.1920621117</a>.","ieee":"R. H. Bloomer <i>et al.</i>, “The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2,” <i>Proceedings of the National Academy of Sciences</i>, vol. 117, no. 28. Proceedings of the National Academy of Sciences, pp. 16660–16666, 2020.","chicago":"Bloomer, Rebecca H., Claire E. Hutchison, Isabel Bäurle, James Walker, Xiaofeng Fang, Pumi Perera, Christos N. Velanis, et al. “The  Arabidopsis Epigenetic Regulator ICU11 as an Accessory Protein of Polycomb Repressive Complex 2.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences, 2020. <a href=\"https://doi.org/10.1073/pnas.1920621117\">https://doi.org/10.1073/pnas.1920621117</a>."},"publication":"Proceedings of the National Academy of Sciences","external_id":{"pmid":["32601198"]},"title":"The  Arabidopsis epigenetic regulator ICU11 as an accessory protein of polycomb repressive complex 2","file":[{"file_size":1105414,"file_name":"2020_PNAS_Bloomer.pdf","date_updated":"2023-02-07T11:29:55Z","success":1,"file_id":"12526","date_created":"2023-02-07T11:29:55Z","checksum":"cedee184cb12f454f2fba4158ff47db9","creator":"alisjak","relation":"main_file","content_type":"application/pdf","access_level":"open_access"}],"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368280/"}],"type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1073/pnas.1920621117","publisher":"Proceedings of the National Academy of Sciences","year":"2020","date_published":"2020-05-22T00:00:00Z","author":[{"full_name":"Bloomer, Rebecca H.","first_name":"Rebecca H.","last_name":"Bloomer"},{"last_name":"Hutchison","first_name":"Claire E.","full_name":"Hutchison, Claire E."},{"first_name":"Isabel","full_name":"Bäurle, Isabel","last_name":"Bäurle"},{"last_name":"Walker","full_name":"Walker, James","first_name":"James"},{"first_name":"Xiaofeng","full_name":"Fang, Xiaofeng","last_name":"Fang"},{"first_name":"Pumi","full_name":"Perera, Pumi","last_name":"Perera"},{"last_name":"Velanis","full_name":"Velanis, Christos N.","first_name":"Christos N."},{"last_name":"Gümüs","full_name":"Gümüs, Serin","first_name":"Serin"},{"first_name":"Christos","full_name":"Spanos, Christos","last_name":"Spanos"},{"full_name":"Rappsilber, Juri","first_name":"Juri","last_name":"Rappsilber"},{"last_name":"Feng","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","orcid":"0000-0002-4008-1234","full_name":"Feng, Xiaoqi","first_name":"Xiaoqi"},{"last_name":"Goodrich","first_name":"Justin","full_name":"Goodrich, Justin"},{"last_name":"Dean","full_name":"Dean, Caroline","first_name":"Caroline"}],"oa":1,"_id":"12188","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["580"],"extern":"1","article_processing_charge":"No","file_date_updated":"2023-02-07T11:29:55Z","keyword":["Multidisciplinary"],"intvolume":"       117","date_created":"2023-01-16T09:15:44Z","pmid":1,"acknowledgement":"We would like to thank Scott Berry for help with ICU-GFP nuclear localization microscopy, Hao Yu and Lisha Shen for assistance with 6mA DNA methylation analysis, Donna Gibson for graphic design assistance, and members of the C.D. and Howard laboratories for helpful discussions. This work was funded by the European Research Council grants to “MEXTIM” (to C.D.) and “SexMeth” (to X. Feng), by the Biotechnological and Biological Sciences Research Council (BBSRC) Institute Strategic Programmes GRO (BB/J004588/1), GEN (BB/P013511/1), BBSRC grant (to X. Feng) (BB/S009620/1), and the Marie Sklodowska–Curie Postdoctoral Fellowships “UNRAVEL” (to R.H.B.) and \"WISDOM\" (to X. Fang). Additional funding via the Wellcome Trust through a Senior Research Fellowship (to J.R.) (103139) and a multiuser equipment grant (108504). The Wellcome Centre for Cell Biology is supported by core funding from the Wellcome Trust (203149).","department":[{"_id":"XiFe"}],"article_type":"original","volume":117,"month":"05","quality_controlled":"1","publication_identifier":{"issn":["0027-8424","1091-6490"]}},{"date_published":"2019-11-13T00:00:00Z","_id":"14001","oa":1,"author":[{"last_name":"Baykusheva","id":"71b4d059-2a03-11ee-914d-dfa3beed6530","first_name":"Denitsa Rangelova","full_name":"Baykusheva, Denitsa Rangelova"},{"first_name":"Daniel","full_name":"Zindel, Daniel","last_name":"Zindel"},{"full_name":"Svoboda, Vít","first_name":"Vít","last_name":"Svoboda"},{"first_name":"Elias","full_name":"Bommeli, Elias","last_name":"Bommeli"},{"full_name":"Ochsner, Manuel","first_name":"Manuel","last_name":"Ochsner"},{"last_name":"Tehlar","full_name":"Tehlar, Andres","first_name":"Andres"},{"last_name":"Wörner","first_name":"Hans Jakob","full_name":"Wörner, Hans Jakob"}],"type":"journal_article","year":"2019","publisher":"Proceedings of the National Academy of Sciences","doi":"10.1073/pnas.1907189116","language":[{"iso":"eng"}],"article_type":"original","volume":116,"publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"quality_controlled":"1","month":"11","intvolume":"       116","keyword":["Multidisciplinary"],"extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","pmid":1,"date_created":"2023-08-09T13:10:36Z","abstract":[{"text":"Chiral molecules interact and react differently with other chiral objects, depending on their handedness. Therefore, it is essential to understand and ultimately control the evolution of molecular chirality during chemical reactions. Although highly sophisticated techniques for the controlled synthesis of chiral molecules have been developed, the observation of chirality on the natural femtosecond time scale of a chemical reaction has so far remained out of reach in the gas phase. Here, we demonstrate a general experimental technique, based on high-harmonic generation in tailored laser fields, and apply it to probe the time evolution of molecular chirality during the photodissociation of 2-iodobutane. These measurements show a change in sign and a pronounced increase in the magnitude of the chiral response over the first 100 fs, followed by its decay within less than 500 fs, revealing the photodissociation to achiral products. The observed time evolution is explained in terms of the variation of the electric and magnetic transition-dipole moments between the lowest electronic states of the cation as a function of the reaction coordinate. These results open the path to investigations of the chirality of molecular-reaction pathways, light-induced chirality in chemical processes, and the control of molecular chirality through tailored laser pulses.","lang":"eng"}],"day":"13","oa_version":"Published Version","page":"23923-23929","publication_status":"published","status":"public","date_updated":"2023-08-22T07:40:05Z","title":"Real-time probing of chirality during a chemical reaction","external_id":{"arxiv":["1906.10818"],"pmid":["31723044"]},"publication":"Proceedings of the National Academy of Sciences","main_file_link":[{"url":"https://doi.org/10.1073/pnas.1907189116","open_access":"1"}],"scopus_import":"1","issue":"48","arxiv":1,"citation":{"mla":"Baykusheva, Denitsa Rangelova, et al. “Real-Time Probing of Chirality during a Chemical Reaction.” <i>Proceedings of the National Academy of Sciences</i>, vol. 116, no. 48, Proceedings of the National Academy of Sciences, 2019, pp. 23923–29, doi:<a href=\"https://doi.org/10.1073/pnas.1907189116\">10.1073/pnas.1907189116</a>.","apa":"Baykusheva, D. R., Zindel, D., Svoboda, V., Bommeli, E., Ochsner, M., Tehlar, A., &#38; Wörner, H. J. (2019). Real-time probing of chirality during a chemical reaction. <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1907189116\">https://doi.org/10.1073/pnas.1907189116</a>","ista":"Baykusheva DR, Zindel D, Svoboda V, Bommeli E, Ochsner M, Tehlar A, Wörner HJ. 2019. Real-time probing of chirality during a chemical reaction. Proceedings of the National Academy of Sciences. 116(48), 23923–23929.","short":"D.R. Baykusheva, D. Zindel, V. Svoboda, E. Bommeli, M. Ochsner, A. Tehlar, H.J. Wörner, Proceedings of the National Academy of Sciences 116 (2019) 23923–23929.","ama":"Baykusheva DR, Zindel D, Svoboda V, et al. Real-time probing of chirality during a chemical reaction. <i>Proceedings of the National Academy of Sciences</i>. 2019;116(48):23923-23929. doi:<a href=\"https://doi.org/10.1073/pnas.1907189116\">10.1073/pnas.1907189116</a>","chicago":"Baykusheva, Denitsa Rangelova, Daniel Zindel, Vít Svoboda, Elias Bommeli, Manuel Ochsner, Andres Tehlar, and Hans Jakob Wörner. “Real-Time Probing of Chirality during a Chemical Reaction.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences, 2019. <a href=\"https://doi.org/10.1073/pnas.1907189116\">https://doi.org/10.1073/pnas.1907189116</a>.","ieee":"D. R. Baykusheva <i>et al.</i>, “Real-time probing of chirality during a chemical reaction,” <i>Proceedings of the National Academy of Sciences</i>, vol. 116, no. 48. Proceedings of the National Academy of Sciences, pp. 23923–23929, 2019."}},{"citation":{"chicago":"Kim, M. Yvonne, Akemi Ono, Stefan Scholten, Tetsu Kinoshita, Daniel Zilberman, Takashi Okamoto, and Robert L. Fischer. “DNA Demethylation by ROS1a in Rice Vegetative Cells Promotes Methylation in Sperm.” <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences, 2019. <a href=\"https://doi.org/10.1073/pnas.1821435116\">https://doi.org/10.1073/pnas.1821435116</a>.","ieee":"M. Y. Kim <i>et al.</i>, “DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm,” <i>Proceedings of the National Academy of Sciences</i>, vol. 116, no. 19. National Academy of Sciences, pp. 9652–9657, 2019.","ista":"Kim MY, Ono A, Scholten S, Kinoshita T, Zilberman D, Okamoto T, Fischer RL. 2019. DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. Proceedings of the National Academy of Sciences. 116(19), 9652–9657.","apa":"Kim, M. Y., Ono, A., Scholten, S., Kinoshita, T., Zilberman, D., Okamoto, T., &#38; Fischer, R. L. (2019). DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. <i>Proceedings of the National Academy of Sciences</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1821435116\">https://doi.org/10.1073/pnas.1821435116</a>","short":"M.Y. Kim, A. Ono, S. Scholten, T. Kinoshita, D. Zilberman, T. Okamoto, R.L. Fischer, Proceedings of the National Academy of Sciences 116 (2019) 9652–9657.","mla":"Kim, M. Yvonne, et al. “DNA Demethylation by ROS1a in Rice Vegetative Cells Promotes Methylation in Sperm.” <i>Proceedings of the National Academy of Sciences</i>, vol. 116, no. 19, National Academy of Sciences, 2019, pp. 9652–57, doi:<a href=\"https://doi.org/10.1073/pnas.1821435116\">10.1073/pnas.1821435116</a>.","ama":"Kim MY, Ono A, Scholten S, et al. DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. <i>Proceedings of the National Academy of Sciences</i>. 2019;116(19):9652-9657. doi:<a href=\"https://doi.org/10.1073/pnas.1821435116\">10.1073/pnas.1821435116</a>"},"has_accepted_license":"1","issue":"19","scopus_import":"1","external_id":{"pmid":["31000601"]},"file":[{"creator":"asandaue","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_name":"2019_PNAS_Kim.pdf","file_size":1142540,"date_created":"2021-06-04T12:50:47Z","file_id":"9461","checksum":"5b0ae3779b8b21b5223bd2d3cceede3a","success":1,"date_updated":"2021-06-04T12:50:47Z"}],"title":"DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm","publication":"Proceedings of the National Academy of Sciences","date_updated":"2021-12-14T07:52:30Z","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","status":"public","abstract":[{"text":"Epigenetic reprogramming is required for proper regulation of gene expression in eukaryotic organisms. In Arabidopsis, active DNA demethylation is crucial for seed viability, pollen function, and successful reproduction. The DEMETER (DME) DNA glycosylase initiates localized DNA demethylation in vegetative and central cells, so-called companion cells that are adjacent to sperm and egg gametes, respectively. In rice, the central cell genome displays local DNA hypomethylation, suggesting that active DNA demethylation also occurs in rice; however, the enzyme responsible for this process is unknown. One candidate is the rice REPRESSOR OF SILENCING 1a (ROS1a) gene, which is related to DME and is essential for rice seed viability and pollen function. Here, we report genome-wide analyses of DNA methylation in wild-type and ros1a mutant sperm and vegetative cells. We find that the rice vegetative cell genome is locally hypomethylated compared with sperm by a process that requires ROS1a activity. We show that many ROS1a target sequences in the vegetative cell are hypomethylated in the rice central cell, suggesting that ROS1a also demethylates the central cell genome. Similar to Arabidopsis, we show that sperm non-CG methylation is indirectly promoted by DNA demethylation in the vegetative cell. These results reveal that DNA glycosylase-mediated DNA demethylation processes are conserved in Arabidopsis and rice, plant species that diverged 150 million years ago. Finally, although global non-CG methylation levels of sperm and egg differ, the maternal and paternal embryo genomes show similar non-CG methylation levels, suggesting that rice gamete genomes undergo dynamic DNA methylation reprogramming after cell fusion.","lang":"eng"}],"publication_status":"published","oa_version":"Published Version","page":"9652-9657","day":"07","tmp":{"image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"pmid":1,"department":[{"_id":"DaZi"}],"date_created":"2021-06-04T12:38:20Z","keyword":["Multidisciplinary"],"intvolume":"       116","extern":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","ddc":["580"],"file_date_updated":"2021-06-04T12:50:47Z","quality_controlled":"1","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"month":"05","volume":116,"article_type":"original","publisher":"National Academy of Sciences","year":"2019","language":[{"iso":"eng"}],"doi":"10.1073/pnas.1821435116","type":"journal_article","oa":1,"_id":"9460","author":[{"last_name":"Kim","first_name":"M. Yvonne","full_name":"Kim, M. Yvonne"},{"last_name":"Ono","full_name":"Ono, Akemi","first_name":"Akemi"},{"last_name":"Scholten","full_name":"Scholten, Stefan","first_name":"Stefan"},{"last_name":"Kinoshita","full_name":"Kinoshita, Tetsu","first_name":"Tetsu"},{"first_name":"Daniel","full_name":"Zilberman, Daniel","last_name":"Zilberman","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","orcid":"0000-0002-0123-8649"},{"full_name":"Okamoto, Takashi","first_name":"Takashi","last_name":"Okamoto"},{"last_name":"Fischer","first_name":"Robert L.","full_name":"Fischer, Robert L."}],"date_published":"2019-05-07T00:00:00Z"},{"scopus_import":"1","issue":"6480","arxiv":1,"citation":{"ama":"Serlin M, Tschirhart CL, Polshyn H, et al. Intrinsic quantized anomalous Hall effect in a moiré heterostructure. <i>Science</i>. 2019;367(6480):900-903. doi:<a href=\"https://doi.org/10.1126/science.aay5533\">10.1126/science.aay5533</a>","apa":"Serlin, M., Tschirhart, C. L., Polshyn, H., Zhang, Y., Zhu, J., Watanabe, K., … Young, A. F. (2019). Intrinsic quantized anomalous Hall effect in a moiré heterostructure. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.aay5533\">https://doi.org/10.1126/science.aay5533</a>","short":"M. Serlin, C.L. Tschirhart, H. Polshyn, Y. Zhang, J. Zhu, K. Watanabe, T. Taniguchi, L. Balents, A.F. Young, Science 367 (2019) 900–903.","ista":"Serlin M, Tschirhart CL, Polshyn H, Zhang Y, Zhu J, Watanabe K, Taniguchi T, Balents L, Young AF. 2019. Intrinsic quantized anomalous Hall effect in a moiré heterostructure. Science. 367(6480), 900–903.","mla":"Serlin, M., et al. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure.” <i>Science</i>, vol. 367, no. 6480, American Association for the Advancement of Science, 2019, pp. 900–03, doi:<a href=\"https://doi.org/10.1126/science.aay5533\">10.1126/science.aay5533</a>.","ieee":"M. Serlin <i>et al.</i>, “Intrinsic quantized anomalous Hall effect in a moiré heterostructure,” <i>Science</i>, vol. 367, no. 6480. American Association for the Advancement of Science, pp. 900–903, 2019.","chicago":"Serlin, M., C. L. Tschirhart, Hryhoriy Polshyn, Y. Zhang, J. Zhu, K. Watanabe, T. Taniguchi, L. Balents, and A. F. Young. “Intrinsic Quantized Anomalous Hall Effect in a Moiré Heterostructure.” <i>Science</i>. American Association for the Advancement of Science, 2019. <a href=\"https://doi.org/10.1126/science.aay5533\">https://doi.org/10.1126/science.aay5533</a>."},"publication":"Science","title":"Intrinsic quantized anomalous Hall effect in a moiré heterostructure","related_material":{"record":[{"relation":"other","id":"10697","status":"public"},{"id":"10698","status":"public","relation":"other"},{"status":"public","id":"10699","relation":"other"}]},"external_id":{"pmid":["31857492"],"arxiv":["1907.00261"]},"main_file_link":[{"url":"https://arxiv.org/abs/1907.00261","open_access":"1"}],"status":"public","date_updated":"2023-02-21T16:00:09Z","day":"19","publication_status":"published","page":"900-903","oa_version":"Preprint","abstract":[{"text":"The quantum anomalous Hall (QAH) effect combines topology and magnetism to produce precisely quantized Hall resistance at zero magnetic field. We report the observation of a QAH effect in twisted bilayer graphene aligned to hexagonal boron nitride. The effect is driven by intrinsic strong interactions, which polarize the electrons into a single spin- and valley-resolved moiré miniband with Chern number C = 1. In contrast to magnetically doped systems, the measured transport energy gap is larger than the Curie temperature for magnetic ordering, and quantization to within 0.1% of the von Klitzing constant persists to temperatures of several kelvin at zero magnetic field. Electrical currents as small as 1 nanoampere controllably switch the magnetic order between states of opposite polarization, forming an electrically rewritable magnetic memory.","lang":"eng"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","extern":"1","intvolume":"       367","keyword":["multidisciplinary"],"date_created":"2022-01-13T14:21:32Z","acknowledgement":"The authors acknowledge discussions with A. Macdonald, Y. Saito, and M. Zaletel.","pmid":1,"volume":367,"article_type":"original","month":"12","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"quality_controlled":"1","type":"journal_article","doi":"10.1126/science.aay5533","language":[{"iso":"eng"}],"year":"2019","publisher":"American Association for the Advancement of Science","date_published":"2019-12-19T00:00:00Z","author":[{"first_name":"M.","full_name":"Serlin, M.","last_name":"Serlin"},{"first_name":"C. L.","full_name":"Tschirhart, C. L.","last_name":"Tschirhart"},{"first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy","id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","orcid":"0000-0001-8223-8896"},{"last_name":"Zhang","full_name":"Zhang, Y.","first_name":"Y."},{"last_name":"Zhu","full_name":"Zhu, J.","first_name":"J."},{"full_name":"Watanabe, K.","first_name":"K.","last_name":"Watanabe"},{"last_name":"Taniguchi","first_name":"T.","full_name":"Taniguchi, T."},{"last_name":"Balents","full_name":"Balents, L.","first_name":"L."},{"first_name":"A. F.","full_name":"Young, A. F.","last_name":"Young"}],"_id":"10619","oa":1},{"date_created":"2022-01-14T12:14:58Z","acknowledgement":"We thank J. Zhu and H. Zhou for experimental assistance and D. Shahar, A. Millis, O. Vafek, M. Zaletel, L. Balents, C. Xu, A. Bernevig, L. Fu, M. Koshino, and P. Moon for helpful discussions.","pmid":1,"extern":"1","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","article_processing_charge":"No","intvolume":"       363","keyword":["multidisciplinary"],"month":"01","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"quality_controlled":"1","article_type":"original","volume":363,"doi":"10.1126/science.aav1910","language":[{"iso":"eng"}],"year":"2019","publisher":"American Association for the Advancement of Science (AAAS)","type":"journal_article","author":[{"first_name":"Matthew","full_name":"Yankowitz, Matthew","last_name":"Yankowitz"},{"full_name":"Chen, Shaowen","first_name":"Shaowen","last_name":"Chen"},{"id":"edfc7cb1-526e-11ec-b05a-e6ecc27e4e48","last_name":"Polshyn","orcid":"0000-0001-8223-8896","first_name":"Hryhoriy","full_name":"Polshyn, Hryhoriy"},{"last_name":"Zhang","first_name":"Yuxuan","full_name":"Zhang, Yuxuan"},{"last_name":"Watanabe","first_name":"K.","full_name":"Watanabe, K."},{"full_name":"Taniguchi, T.","first_name":"T.","last_name":"Taniguchi"},{"first_name":"David","full_name":"Graf, David","last_name":"Graf"},{"full_name":"Young, Andrea F.","first_name":"Andrea F.","last_name":"Young"},{"last_name":"Dean","first_name":"Cory R.","full_name":"Dean, Cory R."}],"_id":"10625","oa":1,"date_published":"2019-01-24T00:00:00Z","citation":{"apa":"Yankowitz, M., Chen, S., Polshyn, H., Zhang, Y., Watanabe, K., Taniguchi, T., … Dean, C. R. (2019). Tuning superconductivity in twisted bilayer graphene. <i>Science</i>. American Association for the Advancement of Science (AAAS). <a href=\"https://doi.org/10.1126/science.aav1910\">https://doi.org/10.1126/science.aav1910</a>","ista":"Yankowitz M, Chen S, Polshyn H, Zhang Y, Watanabe K, Taniguchi T, Graf D, Young AF, Dean CR. 2019. Tuning superconductivity in twisted bilayer graphene. Science. 363(6431), 1059–1064.","mla":"Yankowitz, Matthew, et al. “Tuning Superconductivity in Twisted Bilayer Graphene.” <i>Science</i>, vol. 363, no. 6431, American Association for the Advancement of Science (AAAS), 2019, pp. 1059–64, doi:<a href=\"https://doi.org/10.1126/science.aav1910\">10.1126/science.aav1910</a>.","short":"M. Yankowitz, S. Chen, H. Polshyn, Y. Zhang, K. Watanabe, T. Taniguchi, D. Graf, A.F. Young, C.R. Dean, Science 363 (2019) 1059–1064.","ama":"Yankowitz M, Chen S, Polshyn H, et al. Tuning superconductivity in twisted bilayer graphene. <i>Science</i>. 2019;363(6431):1059-1064. doi:<a href=\"https://doi.org/10.1126/science.aav1910\">10.1126/science.aav1910</a>","chicago":"Yankowitz, Matthew, Shaowen Chen, Hryhoriy Polshyn, Yuxuan Zhang, K. Watanabe, T. Taniguchi, David Graf, Andrea F. Young, and Cory R. Dean. “Tuning Superconductivity in Twisted Bilayer Graphene.” <i>Science</i>. American Association for the Advancement of Science (AAAS), 2019. <a href=\"https://doi.org/10.1126/science.aav1910\">https://doi.org/10.1126/science.aav1910</a>.","ieee":"M. Yankowitz <i>et al.</i>, “Tuning superconductivity in twisted bilayer graphene,” <i>Science</i>, vol. 363, no. 6431. American Association for the Advancement of Science (AAAS), pp. 1059–1064, 2019."},"arxiv":1,"scopus_import":"1","issue":"6431","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1808.07865"}],"publication":"Science","title":"Tuning superconductivity in twisted bilayer graphene","external_id":{"pmid":["30679385 "],"arxiv":["1808.07865"]},"date_updated":"2022-01-14T13:48:32Z","status":"public","day":"24","oa_version":"Preprint","publication_status":"published","page":"1059-1064","abstract":[{"lang":"eng","text":"The discovery of superconductivity and exotic insulating phases in twisted bilayer graphene has established this material as a model system of strongly correlated electrons. To achieve superconductivity, the two layers of graphene need to be at a very precise angle with respect to each other. Yankowitz et al. now show that another experimental knob, hydrostatic pressure, can be used to tune the phase diagram of twisted bilayer graphene (see the Perspective by Feldman). Applying pressure increased the coupling between the layers, which shifted the superconducting transition to higher angles and somewhat higher temperatures."}]},{"publication":"Scientific Reports","external_id":{"pmid":["29426833"],"isi":["000424630400037"]},"file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","creator":"dernst","success":1,"date_updated":"2020-10-06T16:35:16Z","checksum":"e642080fcbde9584c63544f587c74f03","date_created":"2020-10-06T16:35:16Z","file_id":"8619","file_size":2818077,"file_name":"2018_ScientificReports_Gregor.pdf"}],"title":"Novel reversibly switchable fluorescent proteins for RESOLFT and STED nanoscopy engineered from the bacterial photoreceptor YtvA","citation":{"mla":"Gregor, Carola, et al. “Novel Reversibly Switchable Fluorescent Proteins for RESOLFT and STED Nanoscopy Engineered from the Bacterial Photoreceptor YtvA.” <i>Scientific Reports</i>, vol. 8, 2724, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41598-018-19947-1\">10.1038/s41598-018-19947-1</a>.","apa":"Gregor, C., Sidenstein, S. C., Andresen, M., Sahl, S. J., Danzl, J. G., &#38; Hell, S. W. (2018). Novel reversibly switchable fluorescent proteins for RESOLFT and STED nanoscopy engineered from the bacterial photoreceptor YtvA. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-018-19947-1\">https://doi.org/10.1038/s41598-018-19947-1</a>","short":"C. Gregor, S.C. Sidenstein, M. Andresen, S.J. Sahl, J.G. Danzl, S.W. Hell, Scientific Reports 8 (2018).","ista":"Gregor C, Sidenstein SC, Andresen M, Sahl SJ, Danzl JG, Hell SW. 2018. Novel reversibly switchable fluorescent proteins for RESOLFT and STED nanoscopy engineered from the bacterial photoreceptor YtvA. Scientific Reports. 8, 2724.","ama":"Gregor C, Sidenstein SC, Andresen M, Sahl SJ, Danzl JG, Hell SW. Novel reversibly switchable fluorescent proteins for RESOLFT and STED nanoscopy engineered from the bacterial photoreceptor YtvA. <i>Scientific Reports</i>. 2018;8. doi:<a href=\"https://doi.org/10.1038/s41598-018-19947-1\">10.1038/s41598-018-19947-1</a>","chicago":"Gregor, Carola, Sven C. Sidenstein, Martin Andresen, Steffen J. Sahl, Johann G Danzl, and Stefan W. Hell. “Novel Reversibly Switchable Fluorescent Proteins for RESOLFT and STED Nanoscopy Engineered from the Bacterial Photoreceptor YtvA.” <i>Scientific Reports</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41598-018-19947-1\">https://doi.org/10.1038/s41598-018-19947-1</a>.","ieee":"C. Gregor, S. C. Sidenstein, M. Andresen, S. J. Sahl, J. G. Danzl, and S. W. Hell, “Novel reversibly switchable fluorescent proteins for RESOLFT and STED nanoscopy engineered from the bacterial photoreceptor YtvA,” <i>Scientific Reports</i>, vol. 8. Springer Nature, 2018."},"has_accepted_license":"1","oa_version":"Published Version","publication_status":"published","day":"09","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"abstract":[{"lang":"eng","text":"The reversibly switchable fluorescent proteins (RSFPs) commonly used for RESOLFT nanoscopy have been developed from fluorescent proteins of the GFP superfamily. These proteins are bright, but exhibit several drawbacks such as relatively large size, oxygen-dependence, sensitivity to low pH, and limited switching speed. Therefore, RSFPs from other origins with improved properties need to be explored. Here, we report the development of two RSFPs based on the LOV domain of the photoreceptor protein YtvA from Bacillus subtilis. LOV domains obtain their fluorescence by association with the abundant cellular cofactor flavin mononucleotide (FMN). Under illumination with blue and ultraviolet light, they undergo a photocycle, making these proteins inherently photoswitchable. Our first improved variant, rsLOV1, can be used for RESOLFT imaging, whereas rsLOV2 proved useful for STED nanoscopy of living cells with a resolution of down to 50 nm. In addition to their smaller size compared to GFP-related proteins (17 kDa instead of 27 kDa) and their usability at low pH, rsLOV1 and rsLOV2 exhibit faster switching kinetics, switching on and off 3 times faster than rsEGFP2, the fastest-switching RSFP reported to date. Therefore, LOV-domain-based RSFPs have potential for applications where the switching speed of GFP-based proteins is limiting."}],"date_updated":"2023-09-19T15:04:49Z","status":"public","month":"02","quality_controlled":"1","publication_identifier":{"issn":["2045-2322"]},"isi":1,"volume":8,"article_type":"original","date_created":"2020-10-06T16:33:37Z","article_number":"2724","pmid":1,"department":[{"_id":"JoDa"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","ddc":["570"],"article_processing_charge":"No","file_date_updated":"2020-10-06T16:35:16Z","keyword":["Multidisciplinary"],"intvolume":"         8","author":[{"last_name":"Gregor","full_name":"Gregor, Carola","first_name":"Carola"},{"last_name":"Sidenstein","first_name":"Sven C.","full_name":"Sidenstein, Sven C."},{"last_name":"Andresen","first_name":"Martin","full_name":"Andresen, Martin"},{"full_name":"Sahl, Steffen J.","first_name":"Steffen J.","last_name":"Sahl"},{"first_name":"Johann G","full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","last_name":"Danzl"},{"first_name":"Stefan W.","full_name":"Hell, Stefan W.","last_name":"Hell"}],"oa":1,"_id":"8618","date_published":"2018-02-09T00:00:00Z","language":[{"iso":"eng"}],"doi":"10.1038/s41598-018-19947-1","publisher":"Springer Nature","year":"2018","type":"journal_article"}]