[{"date_created":"2023-11-27T07:56:37Z","department":[{"_id":"AnSa"}],"language":[{"iso":"eng"}],"publisher":"Springer Nature","article_type":"original","date_published":"2023-11-15T00:00:00Z","month":"11","publication":"Nature","status":"public","type":"journal_article","day":"15","related_material":{"record":[{"status":"public","relation":"research_data","id":"14472"}],"link":[{"url":"https://doi.org/10.1038/s41586-023-06882-z","relation":"erratum"}]},"main_file_link":[{"url":"https://doi.org/10.1038/s41586-023-06726-w","open_access":"1"}],"title":"Stress granules plug and stabilize damaged endolysosomal membranes","external_id":{"pmid":["37968398"]},"year":"2023","doi":"10.1038/s41586-023-06726-w","acknowledgement":"We thank the Human Embryonic Stem Cell Unit, Advanced Light Microscopy and High-throughput Screening facilities at the Crick for their support in various aspects of the work. We thank the laboratory of P. Anderson for providing the G3BP-DKO U2OS cells. The authors thank N. Chen for providing the purified glycinin protein; Z. Zhao for providing the microfluidic chip wafers; and M. Amaral and F. Frey for helpful discussions and valuable input regarding analysis methods. This work was supported by the Francis Crick Institute (to M.G.G.), which receives its core funding from Cancer Research UK (FC001092), the UK Medical Research Council (FC001092) and the Wellcome Trust (FC001092). This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 772022 to M.G.G.). C.B. has received funding from the European Respiratory Society and the European Union’s H2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 713406. A.M. acknowledges support from Alexander von Humboldt Foundation and C.V.-C. acknowledges funding by the Royal Society and the European Research Council under the European Union’s Horizon 2020 Research and Innovation Programme (grant no. 802960 to A.S.). All simulations were carried out on the high-performance computing cluster at the Institute of Science and Technology Austria. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission.\r\nOpen Access funding provided by The Francis Crick Institute.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa_version":"Published Version","_id":"14610","pmid":1,"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"date_updated":"2023-11-27T09:05:08Z","oa":1,"article_processing_charge":"Yes (via OA deal)","keyword":["Multidisciplinary"],"author":[{"full_name":"Bussi, Claudio","last_name":"Bussi","first_name":"Claudio"},{"first_name":"Agustín","last_name":"Mangiarotti","full_name":"Mangiarotti, Agustín"},{"last_name":"Vanhille-Campos","full_name":"Vanhille-Campos, Christian Eduardo","first_name":"Christian Eduardo","id":"3adeca52-9313-11ed-b1ac-c170b2505714"},{"full_name":"Aylan, Beren","last_name":"Aylan","first_name":"Beren"},{"first_name":"Enrica","last_name":"Pellegrino","full_name":"Pellegrino, Enrica"},{"full_name":"Athanasiadi, Natalia","last_name":"Athanasiadi","first_name":"Natalia"},{"first_name":"Antony","full_name":"Fearns, Antony","last_name":"Fearns"},{"full_name":"Rodgers, Angela","last_name":"Rodgers","first_name":"Angela"},{"full_name":"Franzmann, Titus M.","last_name":"Franzmann","first_name":"Titus M."},{"first_name":"Anđela","orcid":"0000-0002-7854-2139","last_name":"Šarić","full_name":"Šarić, Anđela","id":"bf63d406-f056-11eb-b41d-f263a6566d8b"},{"full_name":"Dimova, Rumiana","last_name":"Dimova","first_name":"Rumiana"},{"last_name":"Gutierrez","full_name":"Gutierrez, Maximiliano G.","first_name":"Maximiliano G."}],"abstract":[{"lang":"eng","text":"<jats:title>Abstract</jats:title><jats:p>Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells<jats:sup>1,2</jats:sup>. To cope with this threat, cells possess mechanisms that repair the damage and restore cellular homeostasis<jats:sup>3–7</jats:sup>. Endomembrane damage also results in organelle instability and the mechanisms by which cells stabilize damaged endomembranes to enable membrane repair remains unknown. Here, by combining in vitro and in cellulo studies with computational modelling we uncover a biological function for stress granules whereby these biomolecular condensates form rapidly at endomembrane damage sites and act as a plug that stabilizes the ruptured membrane. Functionally, we demonstrate that stress granule formation and membrane stabilization enable efficient repair of damaged endolysosomes, through both ESCRT (endosomal sorting complex required for transport)-dependent and independent mechanisms. We also show that blocking stress granule formation in human macrophages creates a permissive environment for <jats:italic>Mycobacterium tuberculosis</jats:italic>, a human pathogen that exploits endomembrane damage to survive within the host.</jats:p>"}],"publication_status":"epub_ahead","citation":{"ista":"Bussi C, Mangiarotti A, Vanhille-Campos CE, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG. 2023. Stress granules plug and stabilize damaged endolysosomal membranes. Nature.","short":"C. Bussi, A. Mangiarotti, C.E. Vanhille-Campos, B. Aylan, E. Pellegrino, N. Athanasiadi, A. Fearns, A. Rodgers, T.M. Franzmann, A. Šarić, R. Dimova, M.G. Gutierrez, Nature (2023).","ama":"Bussi C, Mangiarotti A, Vanhille-Campos CE, et al. Stress granules plug and stabilize damaged endolysosomal membranes. <i>Nature</i>. 2023. doi:<a href=\"https://doi.org/10.1038/s41586-023-06726-w\">10.1038/s41586-023-06726-w</a>","mla":"Bussi, Claudio, et al. “Stress Granules Plug and Stabilize Damaged Endolysosomal Membranes.” <i>Nature</i>, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1038/s41586-023-06726-w\">10.1038/s41586-023-06726-w</a>.","chicago":"Bussi, Claudio, Agustín Mangiarotti, Christian Eduardo Vanhille-Campos, Beren Aylan, Enrica Pellegrino, Natalia Athanasiadi, Antony Fearns, et al. “Stress Granules Plug and Stabilize Damaged Endolysosomal Membranes.” <i>Nature</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41586-023-06726-w\">https://doi.org/10.1038/s41586-023-06726-w</a>.","apa":"Bussi, C., Mangiarotti, A., Vanhille-Campos, C. E., Aylan, B., Pellegrino, E., Athanasiadi, N., … Gutierrez, M. G. (2023). Stress granules plug and stabilize damaged endolysosomal membranes. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-023-06726-w\">https://doi.org/10.1038/s41586-023-06726-w</a>","ieee":"C. Bussi <i>et al.</i>, “Stress granules plug and stabilize damaged endolysosomal membranes,” <i>Nature</i>. Springer Nature, 2023."}},{"publication":"Science Advances","issue":"34","file_date_updated":"2024-01-16T09:35:28Z","day":"25","type":"journal_article","intvolume":"         9","status":"public","has_accepted_license":"1","department":[{"_id":"FlSc"}],"file":[{"success":1,"relation":"main_file","content_type":"application/pdf","creator":"dernst","file_id":"14809","file_size":1596639,"file_name":"2023_ScienceAdvances_GallardoDodd.pdf","checksum":"b9072e20e2d5d9d34d2c53319bafee41","date_created":"2024-01-16T09:35:28Z","access_level":"open_access","date_updated":"2024-01-16T09:35:28Z"}],"date_created":"2024-01-10T09:48:01Z","month":"08","date_published":"2023-08-25T00:00:00Z","article_type":"original","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"article_processing_charge":"Yes","oa":1,"volume":9,"date_updated":"2024-01-16T09:38:58Z","publication_identifier":{"issn":["2375-2548"]},"_id":"14784","pmid":1,"quality_controlled":"1","oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This work was supported by a postdoctoral fellowship from the Swedish Society for Medical Research to J.R., a CAPES-STINT joint grant to R.G.G. and L.S.W., a PhD fellowship from Karolinska Institutet (KID) to E.D., a PhD fellowship from Fundação para a Ciência e a Tecnologia and European Social Fund to M.M.S.O., the program of fundamental research (theme 65.1) of the Institute for Biomedical Problems of the Russian Academy of Sciences (IBMP RAS) to A.A.S., S.M.S., V.A.S., O.V.K., D.D.V., K.D.O., M.P.R., and S.A.P., the Tamkeen under the NYU Abu Dhabi Research Institute Award to the NYUAD Center for Genomics and Systems Biology (ADHPG-CGSB) to P.P., the Knut and Alice Wallenberg foundation to C.K., the Swedish National Space Agency to N.V.K. and L.S.W., Swedish Research Council, Gösta Fraenckel Foundation, and Karolinska Institutet to L.S.W.","citation":{"ieee":"C. J. Gallardo-Dodd <i>et al.</i>, “Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells,” <i>Science Advances</i>, vol. 9, no. 34. American Association for the Advancement of Science, 2023.","apa":"Gallardo-Dodd, C. J., Oertlin, C., Record, J., Galvani, R. G., Sommerauer, C., Kuznetsov, N. V., … Westerberg, L. S. (2023). Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.adg1610\">https://doi.org/10.1126/sciadv.adg1610</a>","chicago":"Gallardo-Dodd, Carlos J., Christian Oertlin, Julien Record, Rômulo G. Galvani, Christian Sommerauer, Nikolai V. Kuznetsov, Evangelos Doukoumopoulos, et al. “Exposure of Volunteers to Microgravity by Dry Immersion Bed over 21 Days Results in Gene Expression Changes and Adaptation of T Cells.” <i>Science Advances</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/sciadv.adg1610\">https://doi.org/10.1126/sciadv.adg1610</a>.","mla":"Gallardo-Dodd, Carlos J., et al. “Exposure of Volunteers to Microgravity by Dry Immersion Bed over 21 Days Results in Gene Expression Changes and Adaptation of T Cells.” <i>Science Advances</i>, vol. 9, no. 34, adg1610, American Association for the Advancement of Science, 2023, doi:<a href=\"https://doi.org/10.1126/sciadv.adg1610\">10.1126/sciadv.adg1610</a>.","ama":"Gallardo-Dodd CJ, Oertlin C, Record J, et al. Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells. <i>Science Advances</i>. 2023;9(34). doi:<a href=\"https://doi.org/10.1126/sciadv.adg1610\">10.1126/sciadv.adg1610</a>","ista":"Gallardo-Dodd CJ, Oertlin C, Record J, Galvani RG, Sommerauer C, Kuznetsov NV, Doukoumopoulos E, Ali L, Oliveira MMS, Seitz C, Percipalle M, Nikić T, Sadova AA, Shulgina SM, Shmarov VA, Kutko OV, Vlasova DD, Orlova KD, Rykova MP, Andersson J, Percipalle P, Kutter C, Ponomarev SA, Westerberg LS. 2023. Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells. Science Advances. 9(34), adg1610.","short":"C.J. Gallardo-Dodd, C. Oertlin, J. Record, R.G. Galvani, C. Sommerauer, N.V. Kuznetsov, E. Doukoumopoulos, L. Ali, M.M.S. Oliveira, C. Seitz, M. Percipalle, T. Nikić, A.A. Sadova, S.M. Shulgina, V.A. Shmarov, O.V. Kutko, D.D. Vlasova, K.D. Orlova, M.P. Rykova, J. Andersson, P. Percipalle, C. Kutter, S.A. Ponomarev, L.S. Westerberg, Science Advances 9 (2023)."},"publication_status":"published","abstract":[{"lang":"eng","text":"The next steps of deep space exploration are manned missions to Moon and Mars. For safe space missions for crew members, it is important to understand the impact of space flight on the immune system. We studied the effects of 21 days dry immersion (DI) exposure on the transcriptomes of T cells isolated from blood samples of eight healthy volunteers. Samples were collected 7 days before DI, at day 7, 14, and 21 during DI, and 7 days after DI. RNA sequencing of CD3+T cells revealed transcriptional alterations across all time points, with most changes occurring 14 days after DI exposure. At day 21, T cells showed evidence of adaptation with a transcriptional profile resembling that of 7 days before DI. At 7 days after DI, T cells again changed their transcriptional profile. These data suggest that T cells adapt by rewiring their transcriptomes in response to simulated weightlessness and that remodeling cues persist when reexposed to normal gravity."}],"keyword":["Multidisciplinary"],"author":[{"full_name":"Gallardo-Dodd, Carlos J.","last_name":"Gallardo-Dodd","first_name":"Carlos J."},{"first_name":"Christian","full_name":"Oertlin, Christian","last_name":"Oertlin"},{"first_name":"Julien","full_name":"Record, Julien","last_name":"Record"},{"first_name":"Rômulo G.","full_name":"Galvani, Rômulo G.","last_name":"Galvani"},{"first_name":"Christian","last_name":"Sommerauer","full_name":"Sommerauer, Christian"},{"first_name":"Nikolai V.","full_name":"Kuznetsov, Nikolai V.","last_name":"Kuznetsov"},{"last_name":"Doukoumopoulos","full_name":"Doukoumopoulos, Evangelos","first_name":"Evangelos"},{"first_name":"Liaqat","full_name":"Ali, Liaqat","last_name":"Ali"},{"full_name":"Oliveira, Mariana M. S.","last_name":"Oliveira","first_name":"Mariana M. S."},{"first_name":"Christina","full_name":"Seitz, Christina","last_name":"Seitz"},{"first_name":"Mathias","full_name":"Percipalle, Mathias","last_name":"Percipalle","id":"45adb726-eb97-11eb-a6c2-c7c3d3caabe9"},{"full_name":"Nikić, Tijana","last_name":"Nikić","first_name":"Tijana"},{"first_name":"Anastasia A.","last_name":"Sadova","full_name":"Sadova, Anastasia A."},{"first_name":"Sofia M.","full_name":"Shulgina, Sofia M.","last_name":"Shulgina"},{"first_name":"Vjacheslav A.","full_name":"Shmarov, Vjacheslav A.","last_name":"Shmarov"},{"full_name":"Kutko, Olga V.","last_name":"Kutko","first_name":"Olga V."},{"last_name":"Vlasova","full_name":"Vlasova, Daria D.","first_name":"Daria D."},{"full_name":"Orlova, Kseniya D.","last_name":"Orlova","first_name":"Kseniya D."},{"first_name":"Marina P.","last_name":"Rykova","full_name":"Rykova, Marina P."},{"full_name":"Andersson, John","last_name":"Andersson","first_name":"John"},{"first_name":"Piergiorgio","last_name":"Percipalle","full_name":"Percipalle, Piergiorgio"},{"last_name":"Kutter","full_name":"Kutter, Claudia","first_name":"Claudia"},{"first_name":"Sergey A.","full_name":"Ponomarev, Sergey A.","last_name":"Ponomarev"},{"last_name":"Westerberg","full_name":"Westerberg, Lisa S.","first_name":"Lisa S."}],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"isi":1,"article_number":"adg1610","ddc":["570"],"year":"2023","doi":"10.1126/sciadv.adg1610","external_id":{"isi":["001054596800007"],"pmid":["37624890"]},"title":"Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells"},{"abstract":[{"lang":"eng","text":"Quantum entanglement is a key resource in currently developed quantum technologies. Sharing this fragile property between superconducting microwave circuits and optical or atomic systems would enable new functionalities, but this has been hindered by an energy scale mismatch of >104 and the resulting mutually imposed loss and noise. In this work, we created and verified entanglement between microwave and optical fields in a millikelvin environment. Using an optically pulsed superconducting electro-optical device, we show entanglement between propagating microwave and optical fields in the continuous variable domain. This achievement not only paves the way for entanglement between superconducting circuits and telecom wavelength light, but also has wide-ranging implications for hybrid quantum networks in the context of modularization, scaling, sensing, and cross-platform verification."}],"keyword":["Multidisciplinary"],"author":[{"full_name":"Sahu, Rishabh","last_name":"Sahu","orcid":"0000-0001-6264-2162","first_name":"Rishabh","id":"47D26E34-F248-11E8-B48F-1D18A9856A87"},{"id":"45e99c0d-1eb1-11eb-9b96-ed8ab2983cac","first_name":"Liu","full_name":"Qiu, Liu","last_name":"Qiu","orcid":"0000-0003-4345-4267"},{"first_name":"William J","last_name":"Hease","full_name":"Hease, William J","orcid":"0000-0001-9868-2166","id":"29705398-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Arnold, Georg M","last_name":"Arnold","orcid":"0000-0003-1397-7876","first_name":"Georg M","id":"3770C838-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Y.","last_name":"Minoguchi","full_name":"Minoguchi, Y."},{"full_name":"Rabl, P.","last_name":"Rabl","first_name":"P."},{"id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes M","full_name":"Fink, Johannes M","last_name":"Fink","orcid":"0000-0001-8112-028X"}],"publication_status":"published","citation":{"ieee":"R. Sahu <i>et al.</i>, “Entangling microwaves with light,” American Association for the Advancement of Science, 2023.","apa":"Sahu, R., Qiu, L., Hease, W. J., Arnold, G. M., Minoguchi, Y., Rabl, P., &#38; Fink, J. M. (2023). <i>Entangling microwaves with light</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adg3812\">https://doi.org/10.1126/science.adg3812</a>","chicago":"Sahu, Rishabh, Liu Qiu, William J Hease, Georg M Arnold, Y. Minoguchi, P. Rabl, and Johannes M Fink. “Entangling Microwaves with Light.” American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.adg3812\">https://doi.org/10.1126/science.adg3812</a>.","ama":"Sahu R, Qiu L, Hease WJ, et al. Entangling microwaves with light. 2023;380:718-721. doi:<a href=\"https://doi.org/10.1126/science.adg3812\">10.1126/science.adg3812</a>","mla":"Sahu, Rishabh, et al. <i>Entangling Microwaves with Light</i>. Vol. 380, American Association for the Advancement of Science, 2023, pp. 718–21, doi:<a href=\"https://doi.org/10.1126/science.adg3812\">10.1126/science.adg3812</a>.","ista":"Sahu R, Qiu L, Hease WJ, Arnold GM, Minoguchi Y, Rabl P, Fink JM. 2023. Entangling microwaves with light. American Association for the Advancement of Science.","short":"R. Sahu, L. Qiu, W.J. Hease, G.M. Arnold, Y. Minoguchi, P. Rabl, J.M. Fink, Entangling Microwaves with Light, American Association for the Advancement of Science, 2023."},"_id":"13106","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","acknowledgement":"This work was supported by the European Research Council (grant no. 758053, ERC StG QUNNECT) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 899354, FETopen SuperQuLAN). L.Q. acknowledges generous support from the ISTFELLOW program. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 Research and Innovation Program (Marie Sklodowska-Curie grant no. 754411). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (grant no. F7105) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 862644, FETopen QUARTET).","oa_version":"Preprint","project":[{"call_identifier":"H2020","_id":"26336814-B435-11E9-9278-68D0E5697425","name":"A Fiber Optic Transceiver for Superconducting Qubits","grant_number":"758053"},{"call_identifier":"H2020","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A","name":"Quantum Local Area Networks with Superconducting Qubits","grant_number":"899354"},{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"},{"call_identifier":"FWF","name":"Integrating superconducting quantum circuits","_id":"26927A52-B435-11E9-9278-68D0E5697425","grant_number":"F07105"},{"_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","name":"Quantum readout techniques and technologies","call_identifier":"H2020","grant_number":"862644"},{"name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies","_id":"2671EB66-B435-11E9-9278-68D0E5697425"}],"arxiv":1,"date_updated":"2025-07-15T09:17:40Z","oa":1,"volume":380,"article_processing_charge":"No","external_id":{"isi":["000996515200004"],"arxiv":["2301.03315"]},"title":"Entangling microwaves with light","doi":"10.1126/science.adg3812","year":"2023","ec_funded":1,"related_material":{"record":[{"id":"13122","relation":"research_data","status":"public"}],"link":[{"url":"https://ista.ac.at/en/news/wiring-up-quantum-circuits-with-light/","relation":"press_release","description":"News on ISTA Website"}]},"isi":1,"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2301.03315","open_access":"1"}],"intvolume":"       380","status":"public","day":"18","type":"dissertation","page":"718-721","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"month":"05","date_published":"2023-05-18T00:00:00Z","date_created":"2023-05-31T11:39:24Z","degree_awarded":"PhD","department":[{"_id":"JoFi"}]},{"date_created":"2023-08-09T13:06:59Z","month":"06","date_published":"2023-06-14T00:00:00Z","article_type":"original","publisher":"Springer Nature","scopus_import":"1","language":[{"iso":"eng"}],"publication":"Nature Communications","day":"14","type":"journal_article","intvolume":"        14","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-023-38540-3"}],"article_number":"3512","doi":"10.1038/s41467-023-38540-3","year":"2023","title":"Witnessing light-driven entanglement using time-resolved resonant inelastic X-ray scattering","external_id":{"pmid":["37316515"],"arxiv":["2209.02283"]},"arxiv":1,"oa":1,"volume":14,"date_updated":"2023-08-22T06:50:04Z","article_processing_charge":"No","pmid":1,"_id":"13989","publication_identifier":{"eissn":["2041-1723"]},"extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa_version":"Published Version","publication_status":"published","citation":{"ieee":"J. Hales <i>et al.</i>, “Witnessing light-driven entanglement using time-resolved resonant inelastic X-ray scattering,” <i>Nature Communications</i>, vol. 14. Springer Nature, 2023.","apa":"Hales, J., Bajpai, U., Liu, T., Baykusheva, D. R., Li, M., Mitrano, M., &#38; Wang, Y. (2023). Witnessing light-driven entanglement using time-resolved resonant inelastic X-ray scattering. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-023-38540-3\">https://doi.org/10.1038/s41467-023-38540-3</a>","chicago":"Hales, Jordyn, Utkarsh Bajpai, Tongtong Liu, Denitsa Rangelova Baykusheva, Mingda Li, Matteo Mitrano, and Yao Wang. “Witnessing Light-Driven Entanglement Using Time-Resolved Resonant Inelastic X-Ray Scattering.” <i>Nature Communications</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41467-023-38540-3\">https://doi.org/10.1038/s41467-023-38540-3</a>.","mla":"Hales, Jordyn, et al. “Witnessing Light-Driven Entanglement Using Time-Resolved Resonant Inelastic X-Ray Scattering.” <i>Nature Communications</i>, vol. 14, 3512, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1038/s41467-023-38540-3\">10.1038/s41467-023-38540-3</a>.","ama":"Hales J, Bajpai U, Liu T, et al. Witnessing light-driven entanglement using time-resolved resonant inelastic X-ray scattering. <i>Nature Communications</i>. 2023;14. doi:<a href=\"https://doi.org/10.1038/s41467-023-38540-3\">10.1038/s41467-023-38540-3</a>","ista":"Hales J, Bajpai U, Liu T, Baykusheva DR, Li M, Mitrano M, Wang Y. 2023. Witnessing light-driven entanglement using time-resolved resonant inelastic X-ray scattering. Nature Communications. 14, 3512.","short":"J. Hales, U. Bajpai, T. Liu, D.R. Baykusheva, M. Li, M. Mitrano, Y. Wang, Nature Communications 14 (2023)."},"abstract":[{"lang":"eng","text":"Characterizing and controlling entanglement in quantum materials is crucial for the development of next-generation quantum technologies. However, defining a quantifiable figure of merit for entanglement in macroscopic solids is theoretically and experimentally challenging. At equilibrium the presence of entanglement can be diagnosed by extracting entanglement witnesses from spectroscopic observables and a nonequilibrium extension of this method could lead to the discovery of novel dynamical phenomena. Here, we propose a systematic approach to quantify the time-dependent quantum Fisher information and entanglement depth of transient states of quantum materials with time-resolved resonant inelastic x-ray scattering. Using a quarter-filled extended Hubbard model as an example, we benchmark the efficiency of this approach and predict a light-enhanced many-body entanglement due to the proximity to a phase boundary. Our work sets the stage for experimentally witnessing and controlling entanglement in light-driven quantum materials via ultrafast spectroscopic measurements."}],"author":[{"full_name":"Hales, Jordyn","last_name":"Hales","first_name":"Jordyn"},{"full_name":"Bajpai, Utkarsh","last_name":"Bajpai","first_name":"Utkarsh"},{"first_name":"Tongtong","last_name":"Liu","full_name":"Liu, Tongtong"},{"id":"71b4d059-2a03-11ee-914d-dfa3beed6530","last_name":"Baykusheva","full_name":"Baykusheva, Denitsa Rangelova","first_name":"Denitsa Rangelova"},{"first_name":"Mingda","last_name":"Li","full_name":"Li, Mingda"},{"last_name":"Mitrano","full_name":"Mitrano, Matteo","first_name":"Matteo"},{"last_name":"Wang","full_name":"Wang, Yao","first_name":"Yao"}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"]},{"article_type":"original","date_published":"2023-01-20T00:00:00Z","month":"01","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"American Association for the Advancement of Science","department":[{"_id":"FlSc"},{"_id":"EM-Fac"}],"has_accepted_license":"1","date_created":"2023-01-23T07:26:42Z","file":[{"date_created":"2023-01-23T07:45:54Z","checksum":"ce81a6d0b84170e5e8c62f6acfa15d9e","file_name":"2023_ScienceAdvances_Faessler.pdf","file_size":1756234,"date_updated":"2023-01-23T07:45:54Z","access_level":"open_access","success":1,"creator":"dernst","file_id":"12335","content_type":"application/pdf","relation":"main_file"}],"type":"journal_article","day":"20","status":"public","intvolume":"         9","file_date_updated":"2023-01-23T07:45:54Z","publication":"Science Advances","issue":"3","year":"2023","doi":"10.1126/sciadv.add6495","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"external_id":{"isi":["000964550100015"]},"title":"ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning","article_number":"add6495","isi":1,"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["570"],"related_material":{"record":[{"id":"14562","relation":"research_data","status":"public"}]},"citation":{"ista":"Fäßler F, Javoor M, Datler J, Döring H, Hofer F, Dimchev GA, Hodirnau V-V, Faix J, Rottner K, Schur FK. 2023. ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. Science Advances. 9(3), add6495.","short":"F. Fäßler, M. Javoor, J. Datler, H. Döring, F. Hofer, G.A. Dimchev, V.-V. Hodirnau, J. Faix, K. Rottner, F.K. Schur, Science Advances 9 (2023).","ama":"Fäßler F, Javoor M, Datler J, et al. ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. <i>Science Advances</i>. 2023;9(3). doi:<a href=\"https://doi.org/10.1126/sciadv.add6495\">10.1126/sciadv.add6495</a>","mla":"Fäßler, Florian, et al. “ArpC5 Isoforms Regulate Arp2/3 Complex–Dependent Protrusion through Differential Ena/VASP Positioning.” <i>Science Advances</i>, vol. 9, no. 3, add6495, American Association for the Advancement of Science, 2023, doi:<a href=\"https://doi.org/10.1126/sciadv.add6495\">10.1126/sciadv.add6495</a>.","chicago":"Fäßler, Florian, Manjunath Javoor, Julia Datler, Hermann Döring, Florian Hofer, Georgi A Dimchev, Victor-Valentin Hodirnau, Jan Faix, Klemens Rottner, and Florian KM Schur. “ArpC5 Isoforms Regulate Arp2/3 Complex–Dependent Protrusion through Differential Ena/VASP Positioning.” <i>Science Advances</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/sciadv.add6495\">https://doi.org/10.1126/sciadv.add6495</a>.","apa":"Fäßler, F., Javoor, M., Datler, J., Döring, H., Hofer, F., Dimchev, G. A., … Schur, F. K. (2023). ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.add6495\">https://doi.org/10.1126/sciadv.add6495</a>","ieee":"F. Fäßler <i>et al.</i>, “ArpC5 isoforms regulate Arp2/3 complex–dependent protrusion through differential Ena/VASP positioning,” <i>Science Advances</i>, vol. 9, no. 3. American Association for the Advancement of Science, 2023."},"publication_status":"published","author":[{"id":"404F5528-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","last_name":"Fäßler","full_name":"Fäßler, Florian","orcid":"0000-0001-7149-769X"},{"id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","first_name":"Manjunath","last_name":"Javoor","full_name":"Javoor, Manjunath"},{"orcid":"0000-0002-3616-8580","last_name":"Datler","full_name":"Datler, Julia","first_name":"Julia","id":"3B12E2E6-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Döring","full_name":"Döring, Hermann","first_name":"Hermann"},{"first_name":"Florian","last_name":"Hofer","full_name":"Hofer, Florian","id":"b9d234ba-9e33-11ed-95b6-cd561df280e6"},{"first_name":"Georgi A","full_name":"Dimchev, Georgi A","last_name":"Dimchev","orcid":"0000-0001-8370-6161","id":"38C393BE-F248-11E8-B48F-1D18A9856A87"},{"id":"3661B498-F248-11E8-B48F-1D18A9856A87","first_name":"Victor-Valentin","last_name":"Hodirnau","full_name":"Hodirnau, Victor-Valentin"},{"first_name":"Jan","last_name":"Faix","full_name":"Faix, Jan"},{"first_name":"Klemens","full_name":"Rottner, Klemens","last_name":"Rottner"},{"id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian KM","orcid":"0000-0003-4790-8078","last_name":"Schur","full_name":"Schur, Florian KM"}],"keyword":["Multidisciplinary"],"abstract":[{"lang":"eng","text":"Regulation of the Arp2/3 complex is required for productive nucleation of branched actin networks. An emerging aspect of regulation is the incorporation of subunit isoforms into the Arp2/3 complex. Specifically, both ArpC5 subunit isoforms, ArpC5 and ArpC5L, have been reported to fine-tune nucleation activity and branch junction stability. We have combined reverse genetics and cellular structural biology to describe how ArpC5 and ArpC5L differentially affect cell migration. Both define the structural stability of ArpC1 in branch junctions and, in turn, by determining protrusion characteristics, affect protein dynamics and actin network ultrastructure. ArpC5 isoforms also affect the positioning of members of the Ena/Vasodilator-stimulated phosphoprotein (VASP) family of actin filament elongators, which mediate ArpC5 isoform–specific effects on the actin assembly level. Our results suggest that ArpC5 and Ena/VASP proteins are part of a signaling pathway enhancing cell migration.</jats:p>"}],"article_processing_charge":"No","volume":9,"oa":1,"date_updated":"2023-11-21T08:05:35Z","project":[{"_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","name":"Structure and isoform diversity of the Arp2/3 complex","grant_number":"P33367"}],"quality_controlled":"1","oa_version":"Published Version","acknowledgement":"We would like to thank K. von Peinen and B. Denker (Helmholtz Centre for Infection Research, Braunschweig, Germany) for experimental and technical assistance, respectively.\r\nThis research was supported by the Scientific Service Units (SSUs) of ISTA through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the Imaging and Optics facility (IOF), and the Electron Microscopy Facility (EMF). We acknowledge support from ISTA and from the Austrian Science Fund (FWF) (P33367) to F.K.M.S., from the Research Training Group GRK2223 and the Helmholtz Society to K.R,. and from the Deutsche Forschungsgemeinschaft (DFG) to J.F. and K.R.","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["2375-2548"]},"_id":"12334"},{"file_date_updated":"2023-05-22T07:57:37Z","publication":"Scientific Reports","issue":"1","status":"public","intvolume":"        13","type":"journal_article","day":"17","date_created":"2023-05-19T11:12:25Z","file":[{"success":1,"creator":"dernst","file_id":"13047","content_type":"application/pdf","relation":"main_file","date_created":"2023-05-22T07:57:37Z","checksum":"8c1b769693ff4288df8376e59ad1176d","file_name":"2023_ScientificReports_Zavadakova.pdf","file_size":3055077,"date_updated":"2023-05-22T07:57:37Z","access_level":"open_access"}],"department":[{"_id":"Bio"}],"has_accepted_license":"1","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"Springer Nature","date_published":"2023-05-17T00:00:00Z","article_type":"original","month":"05","quality_controlled":"1","oa_version":"Published Version","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"The study was supported by Project No. CZ.02.1.01/0.0/0.0/16_019/0000787 “Fighting INfectious Diseases”, awarded by the MEYS CR, financed from EFRR, by the Cooperatio Program, research area DIAG and research area MED/DIAG, by the profiBONE project (TO01000309) benefitting from a € (1.433.000) grant from Iceland, Liechtenstein and Norway through the EEA Grants and the Technology Agency of the Czech Republic and by a Grant (#1926990) to PRM and SRC Biosciences from the National Science Foundation (U.S. Public Health Service). The authors acknowledge the invaluable assistance provided by Iveta Paurova via her support in terms of the provision of laboratory services.","publication_identifier":{"issn":["2045-2322"]},"_id":"13033","article_processing_charge":"No","date_updated":"2023-08-01T14:46:06Z","volume":13,"oa":1,"keyword":["Multidisciplinary"],"author":[{"full_name":"Zavadakova, Anna","last_name":"Zavadakova","first_name":"Anna"},{"last_name":"Vistejnova","full_name":"Vistejnova, Lucie","first_name":"Lucie"},{"id":"0bf89b6a-d28b-11eb-8bd6-f43768e4d368","full_name":"Belinova, Tereza","last_name":"Belinova","first_name":"Tereza"},{"first_name":"Filip","full_name":"Tichanek, Filip","last_name":"Tichanek"},{"first_name":"Dagmar","full_name":"Bilikova, Dagmar","last_name":"Bilikova"},{"full_name":"Mouton, Peter R.","last_name":"Mouton","first_name":"Peter R."}],"abstract":[{"text":"Current methods for assessing cell proliferation in 3D scaffolds rely on changes in metabolic activity or total DNA, however, direct quantification of cell number in 3D scaffolds remains a challenge. To address this issue, we developed an unbiased stereology approach that uses systematic-random sampling and thin focal-plane optical sectioning of the scaffolds followed by estimation of total cell number (StereoCount). This approach was validated against an indirect method for measuring the total DNA (DNA content); and the Bürker counting chamber, the current reference method for quantifying cell number. We assessed the total cell number for cell seeding density (cells per unit volume) across four values and compared the methods in terms of accuracy, ease-of-use and time demands. The accuracy of StereoCount markedly outperformed the DNA content for cases with ~ 10,000 and ~ 125,000 cells/scaffold. For cases with ~ 250,000 and ~ 375,000 cells/scaffold both StereoCount and DNA content showed lower accuracy than the Bürker but did not differ from each other. In terms of ease-of-use, there was a strong advantage for the StereoCount due to output in terms of absolute cell numbers along with the possibility for an overview of cell distribution and future use of automation for high throughput analysis. Taking together, the StereoCount method is an efficient approach for direct cell quantification in 3D collagen scaffolds. Its major benefit is that automated StereoCount could accelerate research using 3D scaffolds focused on drug discovery for a wide variety of human diseases.","lang":"eng"}],"citation":{"chicago":"Zavadakova, Anna, Lucie Vistejnova, Tereza Belinova, Filip Tichanek, Dagmar Bilikova, and Peter R. Mouton. “Novel Stereological Method for Estimation of Cell Counts in 3D Collagen Scaffolds.” <i>Scientific Reports</i>. Springer Nature, 2023. <a href=\"https://doi.org/10.1038/s41598-023-35162-z\">https://doi.org/10.1038/s41598-023-35162-z</a>.","ieee":"A. Zavadakova, L. Vistejnova, T. Belinova, F. Tichanek, D. Bilikova, and P. R. Mouton, “Novel stereological method for estimation of cell counts in 3D collagen scaffolds,” <i>Scientific Reports</i>, vol. 13, no. 1. Springer Nature, 2023.","apa":"Zavadakova, A., Vistejnova, L., Belinova, T., Tichanek, F., Bilikova, D., &#38; Mouton, P. R. (2023). Novel stereological method for estimation of cell counts in 3D collagen scaffolds. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-023-35162-z\">https://doi.org/10.1038/s41598-023-35162-z</a>","short":"A. Zavadakova, L. Vistejnova, T. Belinova, F. Tichanek, D. Bilikova, P.R. Mouton, Scientific Reports 13 (2023).","ista":"Zavadakova A, Vistejnova L, Belinova T, Tichanek F, Bilikova D, Mouton PR. 2023. Novel stereological method for estimation of cell counts in 3D collagen scaffolds. Scientific Reports. 13(1), 7959.","ama":"Zavadakova A, Vistejnova L, Belinova T, Tichanek F, Bilikova D, Mouton PR. Novel stereological method for estimation of cell counts in 3D collagen scaffolds. <i>Scientific Reports</i>. 2023;13(1). doi:<a href=\"https://doi.org/10.1038/s41598-023-35162-z\">10.1038/s41598-023-35162-z</a>","mla":"Zavadakova, Anna, et al. “Novel Stereological Method for Estimation of Cell Counts in 3D Collagen Scaffolds.” <i>Scientific Reports</i>, vol. 13, no. 1, 7959, Springer Nature, 2023, doi:<a href=\"https://doi.org/10.1038/s41598-023-35162-z\">10.1038/s41598-023-35162-z</a>."},"publication_status":"published","ddc":["570"],"related_material":{"link":[{"url":"https://doi.org/10.1038/s41598-023-37265-z","relation":"erratum"}]},"isi":1,"article_number":"7959","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"title":"Novel stereological method for estimation of cell counts in 3D collagen scaffolds","external_id":{"isi":["000995271600104"]},"year":"2023","doi":"10.1038/s41598-023-35162-z"},{"date_created":"2022-08-04T20:06:49Z","file":[{"access_level":"open_access","date_updated":"2022-08-08T07:42:09Z","file_size":2506262,"file_name":"2022_PNAS_Li.pdf","checksum":"ae6f19b0d9efba6687f9e4dc1bab1d6e","date_created":"2022-08-08T07:42:09Z","relation":"main_file","content_type":"application/pdf","creator":"dernst","file_id":"11747","success":1}],"has_accepted_license":"1","department":[{"_id":"GradSch"},{"_id":"JiFr"}],"publisher":"Proceedings of the National Academy of Sciences","scopus_import":"1","language":[{"iso":"eng"}],"month":"07","article_type":"original","date_published":"2022-07-25T00:00:00Z","issue":"31","publication":"Proceedings of the National Academy of Sciences","file_date_updated":"2022-08-08T07:42:09Z","intvolume":"       119","status":"public","day":"25","type":"journal_article","ddc":["580"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"isi":1,"article_number":"e2121058119","title":"RALF1 peptide triggers biphasic root growth inhibition upstream of auxin biosynthesis","external_id":{"isi":["000881496900002"],"pmid":["35878023"]},"doi":"10.1073/pnas.2121058119","year":"2022","_id":"11723","pmid":1,"publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"acknowledgement":"We thank Sarah M. Assmann, Kris Vissenberg, and Nadine Paris for kindly sharing seeds; Matyáš Fendrych for initiating this project and providing constant support; Lukas Fiedler for revising the manuscript; and Huibin Han and Arseny Savin for contributing to genotyping. This work was supported by the Austrian Science Fund (FWF) I 3630-B25 (to J.F.) and the Doctoral Fellowship Progrmme of the Austrian Academy of Sciences (to L.L.) We also acknowledge Taif University Researchers Supporting Project TURSP-HC2021/02 and funding “Plants as a tool for sustainable global development (no. CZ.02.1.01/0.0/0.0/16_019/0000827).”","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","project":[{"grant_number":"I03630","call_identifier":"FWF","name":"Molecular mechanisms of endocytic cargo recognition in plants","_id":"26538374-B435-11E9-9278-68D0E5697425"},{"_id":"26B4D67E-B435-11E9-9278-68D0E5697425","name":"A Case Study of Plant Growth Regulation: Molecular Mechanism of Auxin-mediated Rapid Growth Inhibition in Arabidopsis Root","grant_number":"25351"}],"quality_controlled":"1","oa_version":"Published Version","oa":1,"date_updated":"2024-10-29T10:12:30Z","volume":119,"article_processing_charge":"No","abstract":[{"text":"Plant cell growth responds rapidly to various stimuli, adapting architecture to environmental changes. Two major endogenous signals regulating growth are the phytohormone auxin and the secreted peptides rapid alkalinization factors (RALFs). Both trigger very rapid cellular responses and also exert long-term effects [Du et al., Annu. Rev. Plant Biol. 71, 379–402 (2020); Blackburn et al., Plant Physiol. 182, 1657–1666 (2020)]. However, the way, in which these distinct signaling pathways converge to regulate growth, remains unknown. Here, using vertical confocal microscopy combined with a microfluidic chip, we addressed the mechanism of RALF action on growth. We observed correlation between RALF1-induced rapid Arabidopsis thaliana root growth inhibition and apoplast alkalinization during the initial phase of the response, and revealed that RALF1 reversibly inhibits primary root growth through apoplast alkalinization faster than within 1 min. This rapid apoplast alkalinization was the result of RALF1-induced net H+ influx and was mediated by the receptor FERONIA (FER). Furthermore, we investigated the cross-talk between RALF1 and the auxin signaling pathways during root growth regulation. The results showed that RALF-FER signaling triggered auxin signaling with a delay of approximately 1 h by up-regulating auxin biosynthesis, thus contributing to sustained RALF1-induced growth inhibition. This biphasic RALF1 action on growth allows plants to respond rapidly to environmental stimuli and also reprogram growth and development in the long term.","lang":"eng"}],"author":[{"id":"367EF8FA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5607-272X","last_name":"Li","full_name":"Li, Lanxin","first_name":"Lanxin"},{"id":"83c96512-15b2-11ec-abd3-b7eede36184f","first_name":"Huihuang","full_name":"Chen, Huihuang","last_name":"Chen"},{"full_name":"Alotaibi, Saqer S.","last_name":"Alotaibi","first_name":"Saqer S."},{"first_name":"Aleš","full_name":"Pěnčík, Aleš","last_name":"Pěnčík"},{"full_name":"Adamowski, Maciek","last_name":"Adamowski","orcid":"0000-0001-6463-5257","first_name":"Maciek","id":"45F536D2-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Novák, Ondřej","last_name":"Novák","first_name":"Ondřej"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","last_name":"Friml","first_name":"Jiří"}],"keyword":["Multidisciplinary"],"publication_status":"published","citation":{"apa":"Li, L., Chen, H., Alotaibi, S. S., Pěnčík, A., Adamowski, M., Novák, O., &#38; Friml, J. (2022). RALF1 peptide triggers biphasic root growth inhibition upstream of auxin biosynthesis. <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2121058119\">https://doi.org/10.1073/pnas.2121058119</a>","ieee":"L. Li <i>et al.</i>, “RALF1 peptide triggers biphasic root growth inhibition upstream of auxin biosynthesis,” <i>Proceedings of the National Academy of Sciences</i>, vol. 119, no. 31. Proceedings of the National Academy of Sciences, 2022.","chicago":"Li, Lanxin, Huihuang Chen, Saqer S. Alotaibi, Aleš Pěnčík, Maciek Adamowski, Ondřej Novák, and Jiří Friml. “RALF1 Peptide Triggers Biphasic Root Growth Inhibition Upstream of Auxin Biosynthesis.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences, 2022. <a href=\"https://doi.org/10.1073/pnas.2121058119\">https://doi.org/10.1073/pnas.2121058119</a>.","ama":"Li L, Chen H, Alotaibi SS, et al. RALF1 peptide triggers biphasic root growth inhibition upstream of auxin biosynthesis. <i>Proceedings of the National Academy of Sciences</i>. 2022;119(31). doi:<a href=\"https://doi.org/10.1073/pnas.2121058119\">10.1073/pnas.2121058119</a>","mla":"Li, Lanxin, et al. “RALF1 Peptide Triggers Biphasic Root Growth Inhibition Upstream of Auxin Biosynthesis.” <i>Proceedings of the National Academy of Sciences</i>, vol. 119, no. 31, e2121058119, Proceedings of the National Academy of Sciences, 2022, doi:<a href=\"https://doi.org/10.1073/pnas.2121058119\">10.1073/pnas.2121058119</a>.","ista":"Li L, Chen H, Alotaibi SS, Pěnčík A, Adamowski M, Novák O, Friml J. 2022. RALF1 peptide triggers biphasic root growth inhibition upstream of auxin biosynthesis. Proceedings of the National Academy of Sciences. 119(31), e2121058119.","short":"L. Li, H. Chen, S.S. Alotaibi, A. Pěnčík, M. Adamowski, O. Novák, J. Friml, Proceedings of the National Academy of Sciences 119 (2022)."}},{"title":"Molecular engineering enables bright blue LEDs","external_id":{"pmid":["36543947"]},"year":"2022","doi":"10.1038/d41586-022-04447-0","keyword":["Multidisciplinary"],"author":[{"full_name":"Utzat, Hendrik","last_name":"Utzat","first_name":"Hendrik"},{"first_name":"Maria","orcid":"0000-0001-5013-2843","full_name":"Ibáñez, Maria","last_name":"Ibáñez","id":"43C61214-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"text":"Future LEDs could be based on lead halide perovskites. A breakthrough in preparing device-compatible solids composed of nanoscale perovskite crystals overcomes a long-standing hurdle in making blue perovskite LEDs.","lang":"eng"}],"citation":{"ista":"Utzat H, Ibáñez M. 2022. Molecular engineering enables bright blue LEDs. Nature. 612(7941), 638–639.","short":"H. Utzat, M. Ibáñez, Nature 612 (2022) 638–639.","mla":"Utzat, Hendrik, and Maria Ibáñez. “Molecular Engineering Enables Bright Blue LEDs.” <i>Nature</i>, vol. 612, no. 7941, Springer Nature, 2022, pp. 638–39, doi:<a href=\"https://doi.org/10.1038/d41586-022-04447-0\">10.1038/d41586-022-04447-0</a>.","ama":"Utzat H, Ibáñez M. Molecular engineering enables bright blue LEDs. <i>Nature</i>. 2022;612(7941):638-639. doi:<a href=\"https://doi.org/10.1038/d41586-022-04447-0\">10.1038/d41586-022-04447-0</a>","chicago":"Utzat, Hendrik, and Maria Ibáñez. “Molecular Engineering Enables Bright Blue LEDs.” <i>Nature</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/d41586-022-04447-0\">https://doi.org/10.1038/d41586-022-04447-0</a>.","ieee":"H. Utzat and M. Ibáñez, “Molecular engineering enables bright blue LEDs,” <i>Nature</i>, vol. 612, no. 7941. Springer Nature, pp. 638–639, 2022.","apa":"Utzat, H., &#38; Ibáñez, M. (2022). Molecular engineering enables bright blue LEDs. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/d41586-022-04447-0\">https://doi.org/10.1038/d41586-022-04447-0</a>"},"publication_status":"published","quality_controlled":"1","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"pmid":1,"_id":"14437","article_processing_charge":"No","date_updated":"2023-10-18T06:26:30Z","volume":612,"language":[{"iso":"eng"}],"publisher":"Springer Nature","article_type":"letter_note","date_published":"2022-12-21T00:00:00Z","month":"12","date_created":"2023-10-17T11:14:43Z","department":[{"_id":"MaIb"}],"status":"public","intvolume":"       612","type":"journal_article","day":"21","page":"638-639","publication":"Nature","issue":"7941"},{"publication":"Science Advances","issue":"28","day":"15","type":"journal_article","intvolume":"         8","status":"public","date_created":"2023-08-09T13:08:04Z","month":"07","date_published":"2022-07-15T00:00:00Z","article_type":"original","scopus_import":"1","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"arxiv":1,"article_processing_charge":"No","oa":1,"date_updated":"2023-08-22T07:24:01Z","volume":8,"extern":"1","publication_identifier":{"eissn":["2375-2548"]},"_id":"13992","pmid":1,"oa_version":"Published Version","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ieee":"V. Svoboda <i>et al.</i>, “Femtosecond photoelectron circular dichroism of chemical reactions,” <i>Science Advances</i>, vol. 8, no. 28. American Association for the Advancement of Science, 2022.","apa":"Svoboda, V., Ram, N. B., Baykusheva, D. R., Zindel, D., Waters, M. D. J., Spenger, B., … Wörner, H. J. (2022). Femtosecond photoelectron circular dichroism of chemical reactions. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.abq2811\">https://doi.org/10.1126/sciadv.abq2811</a>","chicago":"Svoboda, Vít, Niraghatam Bhargava Ram, Denitsa Rangelova Baykusheva, Daniel Zindel, Max D. J. Waters, Benjamin Spenger, Manuel Ochsner, Holger Herburger, Jürgen Stohner, and Hans Jakob Wörner. “Femtosecond Photoelectron Circular Dichroism of Chemical Reactions.” <i>Science Advances</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/sciadv.abq2811\">https://doi.org/10.1126/sciadv.abq2811</a>.","mla":"Svoboda, Vít, et al. “Femtosecond Photoelectron Circular Dichroism of Chemical Reactions.” <i>Science Advances</i>, vol. 8, no. 28, abq2811, American Association for the Advancement of Science, 2022, doi:<a href=\"https://doi.org/10.1126/sciadv.abq2811\">10.1126/sciadv.abq2811</a>.","ama":"Svoboda V, Ram NB, Baykusheva DR, et al. Femtosecond photoelectron circular dichroism of chemical reactions. <i>Science Advances</i>. 2022;8(28). doi:<a href=\"https://doi.org/10.1126/sciadv.abq2811\">10.1126/sciadv.abq2811</a>","short":"V. Svoboda, N.B. Ram, D.R. Baykusheva, D. Zindel, M.D.J. Waters, B. Spenger, M. Ochsner, H. Herburger, J. Stohner, H.J. Wörner, Science Advances 8 (2022).","ista":"Svoboda V, Ram NB, Baykusheva DR, Zindel D, Waters MDJ, Spenger B, Ochsner M, Herburger H, Stohner J, Wörner HJ. 2022. Femtosecond photoelectron circular dichroism of chemical reactions. Science Advances. 8(28), abq2811."},"publication_status":"published","abstract":[{"text":"Understanding the chirality of molecular reaction pathways is essential for a broad range of fundamental and applied sciences. However, the current ability to probe chirality on the time scale of primary processes underlying chemical reactions remains very limited. Here, we demonstrate time-resolved photoelectron circular dichroism (TRPECD) with ultrashort circularly polarized vacuum-ultraviolet (VUV) pulses from a tabletop source. We demonstrate the capabilities of VUV-TRPECD by resolving the chirality changes in time during the photodissociation of atomic iodine from two chiral molecules. We identify several general key features of TRPECD, which include the ability to probe dynamical chirality along the complete photochemical reaction path, the sensitivity to the local chirality of the evolving scattering potential, and the influence of electron scattering off dissociating photofragments. Our results are interpreted by comparison with high-level ab-initio calculations of transient PECDs from molecular photoionization calculations. Our experimental and theoretical techniques define a general approach to femtochirality.","lang":"eng"}],"author":[{"last_name":"Svoboda","full_name":"Svoboda, Vít","first_name":"Vít"},{"first_name":"Niraghatam Bhargava","full_name":"Ram, Niraghatam Bhargava","last_name":"Ram"},{"first_name":"Denitsa Rangelova","last_name":"Baykusheva","full_name":"Baykusheva, Denitsa Rangelova","id":"71b4d059-2a03-11ee-914d-dfa3beed6530"},{"last_name":"Zindel","full_name":"Zindel, Daniel","first_name":"Daniel"},{"last_name":"Waters","full_name":"Waters, Max D. J.","first_name":"Max D. J."},{"full_name":"Spenger, Benjamin","last_name":"Spenger","first_name":"Benjamin"},{"first_name":"Manuel","full_name":"Ochsner, Manuel","last_name":"Ochsner"},{"full_name":"Herburger, Holger","last_name":"Herburger","first_name":"Holger"},{"full_name":"Stohner, Jürgen","last_name":"Stohner","first_name":"Jürgen"},{"last_name":"Wörner","full_name":"Wörner, Hans Jakob","first_name":"Hans Jakob"}],"keyword":["Multidisciplinary"],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1126/sciadv.abq2811"}],"article_number":"abq2811","year":"2022","doi":"10.1126/sciadv.abq2811","title":"Femtosecond photoelectron circular dichroism of chemical reactions","external_id":{"arxiv":["2206.04099"],"pmid":["35857523"]}},{"article_type":"original","date_published":"2022-08-16T00:00:00Z","month":"08","language":[{"iso":"eng"}],"publisher":"Springer Nature","department":[{"_id":"JoCs"},{"_id":"PeJo"},{"_id":"JoDa"}],"has_accepted_license":"1","file":[{"date_updated":"2022-08-26T11:51:40Z","access_level":"open_access","date_created":"2022-08-26T11:51:40Z","checksum":"405936d9e4d33625d80c093c9713a91f","file_name":"2022_NatureCommunications_BenSimon.pdf","file_size":5910357,"file_id":"11990","creator":"dernst","content_type":"application/pdf","relation":"main_file","success":1}],"date_created":"2022-08-24T08:25:50Z","type":"journal_article","day":"16","status":"public","intvolume":"        13","file_date_updated":"2022-08-26T11:51:40Z","publication":"Nature Communications","ec_funded":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"SSU"}],"year":"2022","doi":"10.1038/s41467-022-32559-8","title":"A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory","external_id":{"isi":["000841396400008"]},"isi":1,"article_number":"4826","tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["570"],"publication_status":"published","citation":{"ama":"Ben Simon Y, Käfer K, Velicky P, Csicsvari JL, Danzl JG, Jonas PM. A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-32559-8\">10.1038/s41467-022-32559-8</a>","mla":"Ben Simon, Yoav, et al. “A Direct Excitatory Projection from Entorhinal Layer 6b Neurons to the Hippocampus Contributes to Spatial Coding and Memory.” <i>Nature Communications</i>, vol. 13, 4826, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-32559-8\">10.1038/s41467-022-32559-8</a>.","ista":"Ben Simon Y, Käfer K, Velicky P, Csicsvari JL, Danzl JG, Jonas PM. 2022. A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory. Nature Communications. 13, 4826.","short":"Y. Ben Simon, K. Käfer, P. Velicky, J.L. Csicsvari, J.G. Danzl, P.M. Jonas, Nature Communications 13 (2022).","ieee":"Y. Ben Simon, K. Käfer, P. Velicky, J. L. Csicsvari, J. G. Danzl, and P. M. Jonas, “A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","apa":"Ben Simon, Y., Käfer, K., Velicky, P., Csicsvari, J. L., Danzl, J. G., &#38; Jonas, P. M. (2022). A direct excitatory projection from entorhinal layer 6b neurons to the hippocampus contributes to spatial coding and memory. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-32559-8\">https://doi.org/10.1038/s41467-022-32559-8</a>","chicago":"Ben Simon, Yoav, Karola Käfer, Philipp Velicky, Jozsef L Csicsvari, Johann G Danzl, and Peter M Jonas. “A Direct Excitatory Projection from Entorhinal Layer 6b Neurons to the Hippocampus Contributes to Spatial Coding and Memory.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-32559-8\">https://doi.org/10.1038/s41467-022-32559-8</a>."},"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"author":[{"id":"43DF3136-F248-11E8-B48F-1D18A9856A87","full_name":"Ben Simon, Yoav","last_name":"Ben Simon","first_name":"Yoav"},{"first_name":"Karola","last_name":"Käfer","full_name":"Käfer, Karola","id":"2DAA49AA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Philipp","orcid":"0000-0002-2340-7431","full_name":"Velicky, Philipp","last_name":"Velicky","id":"39BDC62C-F248-11E8-B48F-1D18A9856A87"},{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","last_name":"Csicsvari","first_name":"Jozsef L"},{"id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","first_name":"Johann G","last_name":"Danzl","full_name":"Danzl, Johann G","orcid":"0000-0001-8559-3973"},{"first_name":"Peter M","last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"text":"The mammalian hippocampal formation (HF) plays a key role in several higher brain functions, such as spatial coding, learning and memory. Its simple circuit architecture is often viewed as a trisynaptic loop, processing input originating from the superficial layers of the entorhinal cortex (EC) and sending it back to its deeper layers. Here, we show that excitatory neurons in layer 6b of the mouse EC project to all sub-regions comprising the HF and receive input from the CA1, thalamus and claustrum. Furthermore, their output is characterized by unique slow-decaying excitatory postsynaptic currents capable of driving plateau-like potentials in their postsynaptic targets. Optogenetic inhibition of the EC-6b pathway affects spatial coding in CA1 pyramidal neurons, while cell ablation impairs not only acquisition of new spatial memories, but also degradation of previously acquired ones. Our results provide evidence of a functional role for cortical layer 6b neurons in the adult brain.","lang":"eng"}],"volume":13,"date_updated":"2023-08-03T13:01:19Z","oa":1,"article_processing_charge":"No","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"We thank F. Marr and A. Schlögl for technical assistance, E. Kralli-Beller for manuscript editing, as well as C. Sommer and the Imaging and Optics Facility of the Institute of Science and Technology Austria (ISTA) for image analysis scripts and microscopy support. We extend our gratitude to J. Wallenschus and D. Rangel Guerrero for technical assistance acquiring single-unit data and I. Gridchyn for help with single-unit clustering. Finally, we also thank B. Suter for discussions, A. Saunders, M. Jösch, and H. Monyer for critically reading earlier versions of the manuscript, C. Petersen for sharing clearing protocols, and the Scientific Service Units of ISTA for efficient support. This project was funded by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (ERC advanced grant No 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award for P.J. and I3600-B27 for J.G.D. and P.V.).","project":[{"grant_number":"692692","call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","name":"Biophysics and circuit function of a giant cortical glumatergic synapse"},{"name":"Optical control of synaptic function via adhesion molecules","_id":"265CB4D0-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"I03600"},{"grant_number":"Z00312","call_identifier":"FWF","name":"The Wittgenstein Prize","_id":"25C5A090-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","oa_version":"Published Version","_id":"11951","publication_identifier":{"issn":["2041-1723"]}},{"citation":{"apa":"Valentini, M., Borovkov, M., Prada, E., Martí-Sánchez, S., Botifoll, M., Hofmann, A. C., … Katsaros, G. (2022). Majorana-like Coulomb spectroscopy in the absence of zero-bias peaks. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-022-05382-w\">https://doi.org/10.1038/s41586-022-05382-w</a>","ieee":"M. Valentini <i>et al.</i>, “Majorana-like Coulomb spectroscopy in the absence of zero-bias peaks,” <i>Nature</i>, vol. 612, no. 7940. Springer Nature, pp. 442–447, 2022.","chicago":"Valentini, Marco, Maksim Borovkov, Elsa Prada, Sara Martí-Sánchez, Marc Botifoll, Andrea C Hofmann, Jordi Arbiol, Ramón Aguado, Pablo San-Jose, and Georgios Katsaros. “Majorana-like Coulomb Spectroscopy in the Absence of Zero-Bias Peaks.” <i>Nature</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41586-022-05382-w\">https://doi.org/10.1038/s41586-022-05382-w</a>.","mla":"Valentini, Marco, et al. “Majorana-like Coulomb Spectroscopy in the Absence of Zero-Bias Peaks.” <i>Nature</i>, vol. 612, no. 7940, Springer Nature, 2022, pp. 442–47, doi:<a href=\"https://doi.org/10.1038/s41586-022-05382-w\">10.1038/s41586-022-05382-w</a>.","ama":"Valentini M, Borovkov M, Prada E, et al. Majorana-like Coulomb spectroscopy in the absence of zero-bias peaks. <i>Nature</i>. 2022;612(7940):442-447. doi:<a href=\"https://doi.org/10.1038/s41586-022-05382-w\">10.1038/s41586-022-05382-w</a>","ista":"Valentini M, Borovkov M, Prada E, Martí-Sánchez S, Botifoll M, Hofmann AC, Arbiol J, Aguado R, San-Jose P, Katsaros G. 2022. Majorana-like Coulomb spectroscopy in the absence of zero-bias peaks. Nature. 612(7940), 442–447.","short":"M. Valentini, M. Borovkov, E. Prada, S. Martí-Sánchez, M. Botifoll, A.C. Hofmann, J. Arbiol, R. Aguado, P. San-Jose, G. Katsaros, Nature 612 (2022) 442–447."},"publication_status":"published","author":[{"first_name":"Marco","full_name":"Valentini, Marco","last_name":"Valentini","id":"C0BB2FAC-D767-11E9-B658-BC13E6697425"},{"first_name":"Maksim","full_name":"Borovkov, Maksim","last_name":"Borovkov","id":"2ac7a0a2-3562-11eb-9256-fbd18ea55087"},{"first_name":"Elsa","full_name":"Prada, Elsa","last_name":"Prada"},{"full_name":"Martí-Sánchez, Sara","last_name":"Martí-Sánchez","first_name":"Sara"},{"first_name":"Marc","last_name":"Botifoll","full_name":"Botifoll, Marc"},{"full_name":"Hofmann, Andrea C","last_name":"Hofmann","first_name":"Andrea C","id":"340F461A-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jordi","last_name":"Arbiol","full_name":"Arbiol, Jordi"},{"first_name":"Ramón","full_name":"Aguado, Ramón","last_name":"Aguado"},{"first_name":"Pablo","last_name":"San-Jose","full_name":"San-Jose, Pablo"},{"last_name":"Katsaros","full_name":"Katsaros, Georgios","orcid":"0000-0001-8342-202X","first_name":"Georgios","id":"38DB5788-F248-11E8-B48F-1D18A9856A87"}],"keyword":["Multidisciplinary"],"abstract":[{"lang":"eng","text":"Hybrid semiconductor–superconductor devices hold great promise for realizing topological quantum computing with Majorana zero modes1,2,3,4,5. However, multiple claims of Majorana detection, based on either tunnelling6,7,8,9,10 or Coulomb blockade (CB) spectroscopy11,12, remain disputed. Here we devise an experimental protocol that allows us to perform both types of measurement on the same hybrid island by adjusting its charging energy via tunable junctions to the normal leads. This method reduces ambiguities of Majorana detections by checking the consistency between CB spectroscopy and zero-bias peaks in non-blockaded transport. Specifically, we observe junction-dependent, even–odd modulated, single-electron CB peaks in InAs/Al hybrid nanowires without concomitant low-bias peaks in tunnelling spectroscopy. We provide a theoretical interpretation of the experimental observations in terms of low-energy, longitudinally confined island states rather than overlapping Majorana modes. Our results highlight the importance of combined measurements on the same device for the identification of topological Majorana zero modes."}],"article_processing_charge":"No","date_updated":"2024-02-21T12:35:33Z","volume":612,"oa":1,"arxiv":1,"project":[{"grant_number":"844511","_id":"26A151DA-B435-11E9-9278-68D0E5697425","name":"Majorana bound states in Ge/SiGe heterostructures","call_identifier":"H2020"}],"quality_controlled":"1","oa_version":"Preprint","acknowledgement":"We thank P. Krogstrup for providing us with the NW materials. We thank A. Higginbotham, E. J. H. Lee, C. Marcus and S. Vaitiekėnas for helpful discussions and G. Steffensen for his input on the diffusive Little-Parks theory. This research was supported by the Scientific Service Units of ISTA through resources provided by the MIBA Machine Shop and the nanofabrication facility; the NOMIS Foundation; the CSIC Interdisciplinary Thematic Platform (PTI+) on Quantum Technologies (PTI-QTEP+). A.H. acknowledges support from H2020-MSCA-IF-2018/844511. ICN2 also acknowledges funding from Generalitat de Catalunya 2017 SGR 327. ICN2 is supported by the Severo Ochoa Program from Spanish MINECO (Grant no. SEV-2017-0706) and is funded by the CERCA Programme/Generalitat de Catalunya. Part of the present work has been performed in the framework of Universitat Autònoma de Barcelona Materials Science PhD programme. Authors acknowledge the use of instrumentation as well as the technical advice provided by the National Facility ELECMI ICTS, node ‘Laboratorio de Microscopías Avanzadas’ at University of Zaragoza. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 823717-ESTEEM3. This study was supported by MCIN with funding from European Union NextGenerationEU (PRTR-C17.I1) and Generalitat de Catalunya. This research is part of the CSIC programme for the Spanish Recovery, Transformation and Resilience Plan funded by the Recovery and Resilience Facility of the European Union, established by the Regulation (EU) 2020/2094. We thank support from Grant PGC2018-097018-BI00, project FlagERA TOPOGRAPH (PCI2018-093026) and project NANOGEN (PID2020-116093RB-C43), funded by MCIN/AEI/10.13039/501100011033/ and by ‘ERDF A way of making Europe’, by the European Union. M. Botifoll acknowledges support from SUR Generalitat de Catalunya and the EU Social Fund (project ref. 2020 FI 00103).","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"_id":"12118","ec_funded":1,"year":"2022","doi":"10.1038/s41586-022-05382-w","acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"NanoFab"}],"title":"Majorana-like Coulomb spectroscopy in the absence of zero-bias peaks","external_id":{"arxiv":["2203.07829"],"isi":["000899725400001"]},"main_file_link":[{"url":" https://doi.org/10.48550/arXiv.2203.07829","open_access":"1"}],"isi":1,"related_material":{"link":[{"relation":"press_release","description":"News on ISTA Website","url":"https://ista.ac.at/en/news/imposter-particles-revealed-and-explained/"}],"record":[{"status":"public","id":"13286","relation":"dissertation_contains"},{"status":"public","relation":"research_data","id":"12522"}]},"type":"journal_article","day":"15","status":"public","intvolume":"       612","page":"442-447","publication":"Nature","issue":"7940","article_type":"original","date_published":"2022-12-15T00:00:00Z","month":"12","language":[{"iso":"eng"}],"scopus_import":"1","publisher":"Springer Nature","department":[{"_id":"GeKa"}],"date_created":"2023-01-12T11:56:45Z"},{"pmid":1,"_id":"12130","publication_identifier":{"issn":["2041-1723"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"We thank A. Cheung,W. Lukowitz, V.Walbot, D.Weijers, and R. Yadegari for critically reading the manuscript; E. Xiong and G. Zhang for preparing some experiments, T. Schuck, J. Gonnering, and P. Engevold for plant care, the Arabidopsis Biological Resource Center (ABRC) for ARF10,ARF16, ARF17, EMS1,MIR160a BAC clones and cDNAs, the SALK_090804 seed, T. Nakagawa for pGBW vectors, Y. Zhao for the YUC1 cDNA, Q. Chen for the pHEE401E vector, R. Yadegari for pAT5G01860::n1GFP, pAT5G45980:n1GFP, pAT5G50490::n1GFP, pAT5G56200:n1GFP vectors, and D.Weijers for the pGreenII KAN SV40-3×GFP and R2D2 vectors, W. Yang for the splmutant, Y. Qin for the pKNU::KNU-VENUS vector and seed, G. Tang for the STTM160/160-48 vector, and L. Colombo for pPIN1::PIN1-GFP spl and pin1-5 seeds. This work was supported by the US National Science Foundation (NSF)-Israel Binational Science Foundation (BSF) research grant to D.Z. (IOS-1322796) and T.A. (2012756). D.Z. also\r\ngratefully acknowledges supports of the Shaw Scientist Award from the Greater Milwaukee Foundation, USDA National Institute of Food and Agriculture (NIFA, 2022-67013-36294), the UWM Discovery and Innovation Grant, the Bradley Catalyst Award from the UWM Research\r\nFoundation, and WiSys and UW System Applied Research Funding Programs.","quality_controlled":"1","oa_version":"Published Version","oa":1,"volume":13,"date_updated":"2023-08-04T08:52:01Z","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Germline determination is essential for species survival and evolution in multicellular organisms. In most flowering plants, formation of the female germline is initiated with specification of one megaspore mother cell (MMC) in each ovule; however, the molecular mechanism underlying this key event remains unclear. Here we report that spatially restricted auxin signaling promotes MMC fate in Arabidopsis. Our results show that the microRNA160 (miR160) targeted gene ARF17 (AUXIN RESPONSE FACTOR17) is required for promoting MMC specification by genetically interacting with the SPL/NZZ (SPOROCYTELESS/NOZZLE) gene. Alterations of auxin signaling cause formation of supernumerary MMCs in an ARF17- and SPL/NZZ-dependent manner. Furthermore, miR160 and ARF17 are indispensable for attaining a normal auxin maximum at the ovule apex via modulating the expression domain of PIN1 (PIN-FORMED1) auxin transporter. Our findings elucidate the mechanism by which auxin signaling promotes the acquisition of female germline cell fate in plants."}],"author":[{"full_name":"Huang, Jian","last_name":"Huang","first_name":"Jian"},{"last_name":"Zhao","full_name":"Zhao, Lei","first_name":"Lei"},{"first_name":"Shikha","full_name":"Malik, Shikha","last_name":"Malik"},{"first_name":"Benjamin R.","last_name":"Gentile","full_name":"Gentile, Benjamin R."},{"first_name":"Va","full_name":"Xiong, Va","last_name":"Xiong"},{"first_name":"Tzahi","last_name":"Arazi","full_name":"Arazi, Tzahi"},{"first_name":"Heather A.","last_name":"Owen","full_name":"Owen, Heather A."},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří","full_name":"Friml, Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596"},{"last_name":"Zhao","full_name":"Zhao, Dazhong","first_name":"Dazhong"}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"publication_status":"published","citation":{"short":"J. Huang, L. Zhao, S. Malik, B.R. Gentile, V. Xiong, T. Arazi, H.A. Owen, J. Friml, D. Zhao, Nature Communications 13 (2022).","ista":"Huang J, Zhao L, Malik S, Gentile BR, Xiong V, Arazi T, Owen HA, Friml J, Zhao D. 2022. Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis. Nature Communications. 13, 6960.","mla":"Huang, Jian, et al. “Specification of Female Germline by MicroRNA Orchestrated Auxin Signaling in Arabidopsis.” <i>Nature Communications</i>, vol. 13, 6960, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-34723-6\">10.1038/s41467-022-34723-6</a>.","ama":"Huang J, Zhao L, Malik S, et al. Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-34723-6\">10.1038/s41467-022-34723-6</a>","chicago":"Huang, Jian, Lei Zhao, Shikha Malik, Benjamin R. Gentile, Va Xiong, Tzahi Arazi, Heather A. Owen, Jiří Friml, and Dazhong Zhao. “Specification of Female Germline by MicroRNA Orchestrated Auxin Signaling in Arabidopsis.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-34723-6\">https://doi.org/10.1038/s41467-022-34723-6</a>.","ieee":"J. Huang <i>et al.</i>, “Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","apa":"Huang, J., Zhao, L., Malik, S., Gentile, B. R., Xiong, V., Arazi, T., … Zhao, D. (2022). Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-34723-6\">https://doi.org/10.1038/s41467-022-34723-6</a>"},"ddc":["580"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_number":"6960","isi":1,"external_id":{"isi":["000884426700001"],"pmid":["36379956"]},"title":"Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis","doi":"10.1038/s41467-022-34723-6","year":"2022","publication":"Nature Communications","file_date_updated":"2023-01-23T11:17:33Z","intvolume":"        13","status":"public","day":"15","type":"journal_article","date_created":"2023-01-12T12:02:41Z","file":[{"success":1,"content_type":"application/pdf","relation":"main_file","creator":"dernst","file_id":"12346","file_name":"2022_NatureCommunications_Huang.pdf","file_size":3375249,"date_created":"2023-01-23T11:17:33Z","checksum":"233922a7b9507d9d48591e6799e4526e","date_updated":"2023-01-23T11:17:33Z","access_level":"open_access"}],"has_accepted_license":"1","department":[{"_id":"JiFr"}],"publisher":"Springer Nature","scopus_import":"1","language":[{"iso":"eng"}],"month":"11","date_published":"2022-11-15T00:00:00Z","article_type":"original"},{"abstract":[{"text":"Complex I is the first enzyme in the respiratory chain, which is responsible for energy production in mitochondria and bacteria1. Complex I couples the transfer of two electrons from NADH to quinone and the translocation of four protons across the membrane2, but the coupling mechanism remains contentious. Here we present cryo-electron microscopy structures of Escherichia coli complex I (EcCI) in different redox states, including catalytic turnover. EcCI exists mostly in the open state, in which the quinone cavity is exposed to the cytosol, allowing access for water molecules, which enable quinone movements. Unlike the mammalian paralogues3, EcCI can convert to the closed state only during turnover, showing that closed and open states are genuine turnover intermediates. The open-to-closed transition results in the tightly engulfed quinone cavity being connected to the central axis of the membrane arm, a source of substrate protons. Consistently, the proportion of the closed state increases with increasing pH. We propose a detailed but straightforward and robust mechanism comprising a ‘domino effect’ series of proton transfers and electrostatic interactions: the forward wave (‘dominoes stacking’) primes the pump, and the reverse wave (‘dominoes falling’) results in the ejection of all pumped protons from the distal subunit NuoL. This mechanism explains why protons exit exclusively from the NuoL subunit and is supported by our mutagenesis data. We contend that this is a universal coupling mechanism of complex I and related enzymes.","lang":"eng"}],"author":[{"full_name":"Kravchuk, Vladyslav","last_name":"Kravchuk","first_name":"Vladyslav","id":"4D62F2A6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Olga","last_name":"Petrova","full_name":"Petrova, Olga","id":"5D8C9660-5D49-11EA-8188-567B3DDC885E"},{"first_name":"Domen","full_name":"Kampjut, Domen","last_name":"Kampjut","id":"37233050-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Wojciechowska-Bason","full_name":"Wojciechowska-Bason, Anna","first_name":"Anna"},{"first_name":"Zara","last_name":"Breese","full_name":"Breese, Zara"},{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A","last_name":"Sazanov","first_name":"Leonid A"}],"keyword":["Multidisciplinary"],"publication_status":"published","citation":{"ama":"Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov LA. A universal coupling mechanism of respiratory complex I. <i>Nature</i>. 2022;609(7928):808-814. doi:<a href=\"https://doi.org/10.1038/s41586-022-05199-7\">10.1038/s41586-022-05199-7</a>","mla":"Kravchuk, Vladyslav, et al. “A Universal Coupling Mechanism of Respiratory Complex I.” <i>Nature</i>, vol. 609, no. 7928, Springer Nature, 2022, pp. 808–14, doi:<a href=\"https://doi.org/10.1038/s41586-022-05199-7\">10.1038/s41586-022-05199-7</a>.","ista":"Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov LA. 2022. A universal coupling mechanism of respiratory complex I. Nature. 609(7928), 808–814.","short":"V. Kravchuk, O. Petrova, D. Kampjut, A. Wojciechowska-Bason, Z. Breese, L.A. Sazanov, Nature 609 (2022) 808–814.","ieee":"V. Kravchuk, O. Petrova, D. Kampjut, A. Wojciechowska-Bason, Z. Breese, and L. A. Sazanov, “A universal coupling mechanism of respiratory complex I,” <i>Nature</i>, vol. 609, no. 7928. Springer Nature, pp. 808–814, 2022.","apa":"Kravchuk, V., Petrova, O., Kampjut, D., Wojciechowska-Bason, A., Breese, Z., &#38; Sazanov, L. A. (2022). A universal coupling mechanism of respiratory complex I. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-022-05199-7\">https://doi.org/10.1038/s41586-022-05199-7</a>","chicago":"Kravchuk, Vladyslav, Olga Petrova, Domen Kampjut, Anna Wojciechowska-Bason, Zara Breese, and Leonid A Sazanov. “A Universal Coupling Mechanism of Respiratory Complex I.” <i>Nature</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41586-022-05199-7\">https://doi.org/10.1038/s41586-022-05199-7</a>."},"_id":"12138","pmid":1,"publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"This research was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Electron Microscopy Facility (EMF), the Life Science Facility (LSF) and the IST high-performance computing cluster. We thank V.-V. Hodirnau from IST Austria EMF, M. Babiak from CEITEC for assistance with collecting cryo-EM data and A. Charnagalov for the assistance with protein purification. V.K. was a recipient of a DOC Fellowship of the Austrian Academy of Sciences at the Institute of Science and Technology, Austria. V.K. and O.P. are funded by the ERC Advanced Grant 101020697 RESPICHAIN to L.S. This work was also supported by the Medical Research Council (UK).","quality_controlled":"1","oa_version":"Submitted Version","project":[{"name":"Structural characterization of E. coli complex I: an important mechanistic model","_id":"238A0A5A-32DE-11EA-91FC-C7463DDC885E","grant_number":"25541"},{"call_identifier":"H2020","_id":"627abdeb-2b32-11ec-9570-ec31a97243d3","name":"Structure and mechanism of respiratory chain molecular machines","grant_number":"101020697"}],"volume":609,"date_updated":"2023-08-04T08:54:52Z","oa":1,"article_processing_charge":"No","title":"A universal coupling mechanism of respiratory complex I","external_id":{"pmid":["36104567"],"isi":["000854788200001"]},"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"LifeSc"},{"_id":"ScienComp"}],"year":"2022","doi":"10.1038/s41586-022-05199-7","ec_funded":1,"related_material":{"record":[{"id":"12781","relation":"dissertation_contains","status":"public"}],"link":[{"url":"https://doi.org/10.1038/s41586-022-05457-8","relation":"erratum"},{"relation":"press_release","description":"News on ISTA website","url":"https://ista.ac.at/en/news/proton-dominos-kick-off-life/"}]},"ddc":["572"],"isi":1,"intvolume":"       609","status":"public","day":"22","type":"journal_article","issue":"7928","publication":"Nature","page":"808-814","file_date_updated":"2023-05-30T17:07:05Z","publisher":"Springer Nature","scopus_import":"1","language":[{"iso":"eng"}],"month":"09","article_type":"original","date_published":"2022-09-22T00:00:00Z","date_created":"2023-01-12T12:04:33Z","file":[{"date_created":"2023-05-30T17:05:31Z","checksum":"d42a93e24f59e883ef0b5429832391d0","file_name":"EcCxI_manuscript_rev3_noSI_updated_withFigs_opt.pdf","file_size":1425655,"date_updated":"2023-05-30T17:05:31Z","access_level":"open_access","success":1,"file_id":"13104","creator":"lsazanov","content_type":"application/pdf","relation":"main_file"},{"date_created":"2023-05-30T17:07:05Z","checksum":"5422bc0a73b3daadafa262c7ea6deae3","file_name":"EcCxI_manuscript_rev3_SI_All_opt_upd.pdf","file_size":9842513,"date_updated":"2023-05-30T17:07:05Z","access_level":"open_access","success":1,"creator":"lsazanov","file_id":"13105","content_type":"application/pdf","relation":"main_file"}],"has_accepted_license":"1","department":[{"_id":"LeSa"}]},{"month":"10","date_published":"2022-10-24T00:00:00Z","article_type":"original","scopus_import":"1","publisher":"Springer Nature","language":[{"iso":"eng"}],"has_accepted_license":"1","department":[{"_id":"StFr"}],"file":[{"content_type":"application/pdf","relation":"main_file","file_id":"12411","creator":"dernst","success":1,"date_updated":"2023-01-27T07:19:11Z","access_level":"open_access","file_name":"2022_NatureCommunications_Prehal.pdf","file_size":4216931,"date_created":"2023-01-27T07:19:11Z","checksum":"5034336dbf0f860030ef745c08df9e0e"}],"date_created":"2023-01-16T09:45:09Z","day":"24","type":"journal_article","intvolume":"        13","status":"public","publication":"Nature Communications","file_date_updated":"2023-01-27T07:19:11Z","doi":"10.1038/s41467-022-33931-4","year":"2022","title":"On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering","external_id":{"isi":["000871563700006"],"pmid":["36280671"]},"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_number":"6326","isi":1,"ddc":["540"],"citation":{"short":"C. Prehal, J.-M. von Mentlen, S. Drvarič Talian, A. Vizintin, R. Dominko, H. Amenitsch, L. Porcar, S.A. Freunberger, V. Wood, Nature Communications 13 (2022).","ista":"Prehal C, von Mentlen J-M, Drvarič Talian S, Vizintin A, Dominko R, Amenitsch H, Porcar L, Freunberger SA, Wood V. 2022. On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. Nature Communications. 13, 6326.","mla":"Prehal, Christian, et al. “On the Nanoscale Structural Evolution of Solid Discharge Products in Lithium-Sulfur Batteries Using Operando Scattering.” <i>Nature Communications</i>, vol. 13, 6326, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-33931-4\">10.1038/s41467-022-33931-4</a>.","ama":"Prehal C, von Mentlen J-M, Drvarič Talian S, et al. On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-33931-4\">10.1038/s41467-022-33931-4</a>","chicago":"Prehal, Christian, Jean-Marc von Mentlen, Sara Drvarič Talian, Alen Vizintin, Robert Dominko, Heinz Amenitsch, Lionel Porcar, Stefan Alexander Freunberger, and Vanessa Wood. “On the Nanoscale Structural Evolution of Solid Discharge Products in Lithium-Sulfur Batteries Using Operando Scattering.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-33931-4\">https://doi.org/10.1038/s41467-022-33931-4</a>.","ieee":"C. Prehal <i>et al.</i>, “On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","apa":"Prehal, C., von Mentlen, J.-M., Drvarič Talian, S., Vizintin, A., Dominko, R., Amenitsch, H., … Wood, V. (2022). On the nanoscale structural evolution of solid discharge products in lithium-sulfur batteries using operando scattering. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-33931-4\">https://doi.org/10.1038/s41467-022-33931-4</a>"},"publication_status":"published","abstract":[{"lang":"eng","text":"The inadequate understanding of the mechanisms that reversibly convert molecular sulfur (S) into lithium sulfide (Li<jats:sub>2</jats:sub>S) via soluble polysulfides (PSs) formation impedes the development of high-performance lithium-sulfur (Li-S) batteries with non-aqueous electrolyte solutions. Here, we use operando small and wide angle X-ray scattering and operando small angle neutron scattering (SANS) measurements to track the nucleation, growth and dissolution of solid deposits from atomic to sub-micron scales during real-time Li-S cell operation. In particular, stochastic modelling based on the SANS data allows quantifying the nanoscale phase evolution during battery cycling. We show that next to nano-crystalline Li<jats:sub>2</jats:sub>S the deposit comprises solid short-chain PSs particles. The analysis of the experimental data suggests that initially, Li<jats:sub>2</jats:sub>S<jats:sub>2</jats:sub> precipitates from the solution and then is partially converted via solid-state electroreduction to Li<jats:sub>2</jats:sub>S. We further demonstrate that mass transport, rather than electron transport through a thin passivating film, limits the discharge capacity and rate performance in Li-S cells."}],"author":[{"first_name":"Christian","full_name":"Prehal, Christian","last_name":"Prehal"},{"full_name":"von Mentlen, Jean-Marc","last_name":"von Mentlen","first_name":"Jean-Marc"},{"full_name":"Drvarič Talian, Sara","last_name":"Drvarič Talian","first_name":"Sara"},{"first_name":"Alen","last_name":"Vizintin","full_name":"Vizintin, Alen"},{"last_name":"Dominko","full_name":"Dominko, Robert","first_name":"Robert"},{"last_name":"Amenitsch","full_name":"Amenitsch, Heinz","first_name":"Heinz"},{"first_name":"Lionel","last_name":"Porcar","full_name":"Porcar, Lionel"},{"first_name":"Stefan Alexander","last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425"},{"full_name":"Wood, Vanessa","last_name":"Wood","first_name":"Vanessa"}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"article_processing_charge":"No","oa":1,"volume":13,"date_updated":"2023-08-04T09:15:31Z","publication_identifier":{"issn":["2041-1723"]},"pmid":1,"_id":"12208","oa_version":"Published Version","quality_controlled":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant NanoEvolution, grant agreement No 894042. The authors acknowledge the CERIC-ERIC Consortium for the access to the Austrian SAXS beamline and TU Graz for support through the Lead Project LP-03.\r\nLikewise, the use of SOMAPP Lab, a core facility supported by the Austrian Federal Ministry of Education, Science and Research, the Graz University of Technology, the University of Graz, and Anton Paar GmbH is acknowledged. In addition, the authors acknowledge access to the D-22SANS beamline at the ILL neutron source. Electron microscopy measurements were performed at the Scientific Scenter for Optical and Electron Microscopy (ScopeM) of the Swiss Federal Institute of Technology. C.P. and J.M.M. thank A. Senol for her support with the SANS\r\nbeamtime preparation. S.D.T, A.V. and R.D. acknowledge the financial support by the Slovenian Research Agency (ARRS) research core funding P2-0393 and P2-0423. Furthermore, A.V. acknowledge the funding from the Slovenian Research Agency, research project Z2−1863.\r\nS.A.F. is indebted to IST Austria for support. "},{"publication":"Nature Communications","file_date_updated":"2023-01-27T08:14:48Z","intvolume":"        13","status":"public","day":"05","type":"journal_article","date_created":"2023-01-16T09:46:53Z","file":[{"checksum":"295261b5172274fd5b8f85a6a6058828","date_created":"2023-01-27T08:14:48Z","file_size":22645149,"file_name":"2022_NatureCommunications_Randriamanantsoa.pdf","access_level":"open_access","date_updated":"2023-01-27T08:14:48Z","success":1,"creator":"dernst","file_id":"12416","relation":"main_file","content_type":"application/pdf"}],"has_accepted_license":"1","department":[{"_id":"EdHa"}],"publisher":"Springer Nature","scopus_import":"1","language":[{"iso":"eng"}],"month":"09","date_published":"2022-09-05T00:00:00Z","article_type":"original","_id":"12217","publication_identifier":{"issn":["2041-1723"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"A.R.B. acknowledges the financial support of the European Research Council (ERC) through the funding of the grant Principles of Integrin Mechanics and Adhesion (PoINT) and the German Research Foundation (DFG, SFB 1032, project ID 201269156). E.H. was supported by the European Union (European Research Council Starting Grant 851288). D.S., M.R., and R.R. acknowledge the support by the German Research Foundation (DFG, SFB1321 Modeling and Targeting Pancreatic Cancer, Project S01, project ID 329628492). C.S. and M.R. acknowledge the support by the German Research Foundation (DFG, SFB1321 Modeling and Targeting Pancreatic Cancer, Project 12, project ID 329628492). M.R. was supported by the German Research Foundation (DFG RE 3723/4-1). A.P. and M.R. were supported by the German Cancer Aid (Max-Eder Program 111273 and 70114328).\r\nOpen Access funding enabled and organized by Projekt DEAL.","project":[{"grant_number":"851288","_id":"05943252-7A3F-11EA-A408-12923DDC885E","name":"Design Principles of Branching Morphogenesis","call_identifier":"H2020"}],"oa_version":"Published Version","quality_controlled":"1","volume":13,"date_updated":"2023-08-04T09:25:23Z","oa":1,"article_processing_charge":"No","abstract":[{"lang":"eng","text":"The development dynamics and self-organization of glandular branched epithelia is of utmost importance for our understanding of diverse processes ranging from normal tissue growth to the growth of cancerous tissues. Using single primary murine pancreatic ductal adenocarcinoma (PDAC) cells embedded in a collagen matrix and adapted media supplementation, we generate organoids that self-organize into highly branched structures displaying a seamless lumen connecting terminal end buds, replicating in vivo PDAC architecture. We identify distinct morphogenesis phases, each characterized by a unique pattern of cell invasion, matrix deformation, protein expression, and respective molecular dependencies. We propose a minimal theoretical model of a branching and proliferating tissue, capturing the dynamics of the first phases. Observing the interaction of morphogenesis, mechanical environment and gene expression in vitro sets a benchmark for the understanding of self-organization processes governing complex organoid structure formation processes and branching morphogenesis."}],"author":[{"full_name":"Randriamanantsoa, S.","last_name":"Randriamanantsoa","first_name":"S."},{"first_name":"A.","last_name":"Papargyriou","full_name":"Papargyriou, A."},{"first_name":"H. C.","full_name":"Maurer, H. C.","last_name":"Maurer"},{"first_name":"K.","last_name":"Peschke","full_name":"Peschke, K."},{"last_name":"Schuster","full_name":"Schuster, M.","first_name":"M."},{"first_name":"G.","full_name":"Zecchin, G.","last_name":"Zecchin"},{"last_name":"Steiger","full_name":"Steiger, K.","first_name":"K."},{"first_name":"R.","last_name":"Öllinger","full_name":"Öllinger, R."},{"full_name":"Saur, D.","last_name":"Saur","first_name":"D."},{"first_name":"C.","last_name":"Scheel","full_name":"Scheel, C."},{"full_name":"Rad, R.","last_name":"Rad","first_name":"R."},{"first_name":"Edouard B","orcid":"0000-0001-6005-1561","last_name":"Hannezo","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"},{"first_name":"M.","full_name":"Reichert, M.","last_name":"Reichert"},{"full_name":"Bausch, A. R.","last_name":"Bausch","first_name":"A. R."}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"publication_status":"published","citation":{"ista":"Randriamanantsoa S, Papargyriou A, Maurer HC, Peschke K, Schuster M, Zecchin G, Steiger K, Öllinger R, Saur D, Scheel C, Rad R, Hannezo EB, Reichert M, Bausch AR. 2022. Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. Nature Communications. 13, 5219.","short":"S. Randriamanantsoa, A. Papargyriou, H.C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, R. Öllinger, D. Saur, C. Scheel, R. Rad, E.B. Hannezo, M. Reichert, A.R. Bausch, Nature Communications 13 (2022).","mla":"Randriamanantsoa, S., et al. “Spatiotemporal Dynamics of Self-Organized Branching in Pancreas-Derived Organoids.” <i>Nature Communications</i>, vol. 13, 5219, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41467-022-32806-y\">10.1038/s41467-022-32806-y</a>.","ama":"Randriamanantsoa S, Papargyriou A, Maurer HC, et al. Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. <i>Nature Communications</i>. 2022;13. doi:<a href=\"https://doi.org/10.1038/s41467-022-32806-y\">10.1038/s41467-022-32806-y</a>","chicago":"Randriamanantsoa, S., A. Papargyriou, H. C. Maurer, K. Peschke, M. Schuster, G. Zecchin, K. Steiger, et al. “Spatiotemporal Dynamics of Self-Organized Branching in Pancreas-Derived Organoids.” <i>Nature Communications</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41467-022-32806-y\">https://doi.org/10.1038/s41467-022-32806-y</a>.","ieee":"S. Randriamanantsoa <i>et al.</i>, “Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids,” <i>Nature Communications</i>, vol. 13. Springer Nature, 2022.","apa":"Randriamanantsoa, S., Papargyriou, A., Maurer, H. C., Peschke, K., Schuster, M., Zecchin, G., … Bausch, A. R. (2022). Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-022-32806-y\">https://doi.org/10.1038/s41467-022-32806-y</a>"},"related_material":{"record":[{"relation":"research_data","id":"13068","status":"public"}]},"ddc":["570"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_number":"5219","isi":1,"title":"Spatiotemporal dynamics of self-organized branching in pancreas-derived organoids","external_id":{"isi":["000850348400025"]},"year":"2022","doi":"10.1038/s41467-022-32806-y","ec_funded":1},{"scopus_import":"1","publisher":"Springer Nature","language":[{"iso":"eng"}],"month":"06","article_type":"original","date_published":"2022-06-02T00:00:00Z","file":[{"access_level":"open_access","date_updated":"2023-01-27T08:56:18Z","file_size":3625627,"file_name":"2022_ScientificReports_Currin.pdf","checksum":"e024a75f14ce5667795a31e44a259c52","date_created":"2023-01-27T08:56:18Z","relation":"main_file","content_type":"application/pdf","creator":"dernst","file_id":"12418","success":1}],"date_created":"2023-01-16T09:48:30Z","has_accepted_license":"1","department":[{"_id":"TiVo"}],"intvolume":"        12","status":"public","day":"02","type":"journal_article","publication":"Scientific Reports","file_date_updated":"2023-01-27T08:56:18Z","external_id":{"pmid":["35654942"],"isi":["000805561200024"]},"title":"Depolarization of echo chambers by random dynamical nudge","doi":"10.1038/s41598-022-12494-w","year":"2022","ddc":["570"],"tmp":{"image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_number":"9234","isi":1,"abstract":[{"text":"In social networks, users often engage with like-minded peers. This selective exposure to opinions might result in echo chambers, i.e., political fragmentation and social polarization of user interactions. When echo chambers form, opinions have a bimodal distribution with two peaks on opposite sides. In certain issues, where either extreme positions contain a degree of misinformation, neutral consensus is preferable for promoting discourse. In this paper, we use an opinion dynamics model that naturally forms echo chambers in order to find a feedback mechanism that bridges these communities and leads to a neutral consensus. We introduce the <jats:italic>random dynamical nudge</jats:italic> (RDN), which presents each agent with input from a random selection of other agents’ opinions and does not require surveillance of every person’s opinions. Our computational results in two different models suggest that the RDN leads to a unimodal distribution of opinions centered around the neutral consensus. Furthermore, the RDN is effective both for preventing the formation of echo chambers and also for depolarizing existing echo chambers. Due to the simple and robust nature of the RDN, social media networks might be able to implement a version of this self-feedback mechanism, when appropriate, to prevent the segregation of online communities on complex social issues.","lang":"eng"}],"keyword":["Multidisciplinary"],"author":[{"id":"e8321fc5-3091-11eb-8a53-83f309a11ac9","first_name":"Christopher","last_name":"Currin","full_name":"Currin, Christopher","orcid":"0000-0002-4809-5059"},{"last_name":"Vera","full_name":"Vera, Sebastián Vallejo","first_name":"Sebastián Vallejo"},{"first_name":"Ali","full_name":"Khaledi-Nasab, Ali","last_name":"Khaledi-Nasab"}],"citation":{"apa":"Currin, C., Vera, S. V., &#38; Khaledi-Nasab, A. (2022). Depolarization of echo chambers by random dynamical nudge. <i>Scientific Reports</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41598-022-12494-w\">https://doi.org/10.1038/s41598-022-12494-w</a>","ieee":"C. Currin, S. V. Vera, and A. Khaledi-Nasab, “Depolarization of echo chambers by random dynamical nudge,” <i>Scientific Reports</i>, vol. 12. Springer Nature, 2022.","chicago":"Currin, Christopher, Sebastián Vallejo Vera, and Ali Khaledi-Nasab. “Depolarization of Echo Chambers by Random Dynamical Nudge.” <i>Scientific Reports</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41598-022-12494-w\">https://doi.org/10.1038/s41598-022-12494-w</a>.","ama":"Currin C, Vera SV, Khaledi-Nasab A. Depolarization of echo chambers by random dynamical nudge. <i>Scientific Reports</i>. 2022;12. doi:<a href=\"https://doi.org/10.1038/s41598-022-12494-w\">10.1038/s41598-022-12494-w</a>","mla":"Currin, Christopher, et al. “Depolarization of Echo Chambers by Random Dynamical Nudge.” <i>Scientific Reports</i>, vol. 12, 9234, Springer Nature, 2022, doi:<a href=\"https://doi.org/10.1038/s41598-022-12494-w\">10.1038/s41598-022-12494-w</a>.","short":"C. Currin, S.V. Vera, A. Khaledi-Nasab, Scientific Reports 12 (2022).","ista":"Currin C, Vera SV, Khaledi-Nasab A. 2022. Depolarization of echo chambers by random dynamical nudge. Scientific Reports. 12, 9234."},"publication_status":"published","publication_identifier":{"issn":["2045-2322"]},"_id":"12225","pmid":1,"quality_controlled":"1","oa_version":"Published Version","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","acknowledgement":"CBC and AKN would like to thank Neuromatch Academy https://www.neuromatchacademy.org for introducing the authors to each other. We thank Dr. Krešimir Josic (University of Houston) , Fabian Baumann (Humboldt University) and Dr. Igor M. Sokolov (Humboldt University) for carefully reading the early versions of the manuscript and providing constructive feedback. CBC is supported by the German Deutscher Akademischer Austauschdienst (DAAD, https://daad.de), the South African National Research Foundation (NRF, https://nrf.ac.za), the University of Cape Town (UCT, https://uct.ac.za), and the NOMIS Foundation through the NOMIS Fellowships at IST Austria program (https://nomisfoundation.ch). SVV appreciate the generosity of Tecnológico de Monterrey for covering the publication fee.","article_processing_charge":"No","date_updated":"2023-08-04T09:26:30Z","volume":12,"oa":1},{"publisher":"Springer Nature","scopus_import":"1","language":[{"iso":"eng"}],"month":"07","date_published":"2022-07-13T00:00:00Z","article_type":"original","date_created":"2023-01-16T10:01:29Z","department":[{"_id":"EdHa"}],"intvolume":"       607","status":"public","day":"13","type":"journal_article","issue":"7919","publication":"Nature","page":"548-554","title":"Retrograde movements determine effective stem cell numbers in the intestine","external_id":{"pmid":["35831497"],"isi":["000824430000004"]},"doi":"10.1038/s41586-022-04962-0","year":"2022","ec_funded":1,"related_material":{"link":[{"relation":"software","url":"https://github.com/JaccovanRheenenLab/Retrograde_movement_Azkanaz_Nature_2022"}]},"main_file_link":[{"url":"https://helda.helsinki.fi/items/94433455-4854-45c0-9de8-7326caea8780","open_access":"1"}],"isi":1,"abstract":[{"lang":"eng","text":"The morphology and functionality of the epithelial lining differ along the intestinal tract, but tissue renewal at all sites is driven by stem cells at the base of crypts1,2,3. Whether stem cell numbers and behaviour vary at different sites is unknown. Here we show using intravital microscopy that, despite similarities in the number and distribution of proliferative cells with an Lgr5 signature in mice, small intestinal crypts contain twice as many effective stem cells as large intestinal crypts. We find that, although passively displaced by a conveyor-belt-like upward movement, small intestinal cells positioned away from the crypt base can function as long-term effective stem cells owing to Wnt-dependent retrograde cellular movement. By contrast, the near absence of retrograde movement in the large intestine restricts cell repositioning, leading to a reduction in effective stem cell number. Moreover, after suppression of the retrograde movement in the small intestine, the number of effective stem cells is reduced, and the rate of monoclonal conversion of crypts is accelerated. Together, these results show that the number of effective stem cells is determined by active retrograde movement, revealing a new channel of stem cell regulation that can be experimentally and pharmacologically manipulated."}],"author":[{"first_name":"Maria","full_name":"Azkanaz, Maria","last_name":"Azkanaz"},{"id":"43BE2298-F248-11E8-B48F-1D18A9856A87","full_name":"Corominas-Murtra, Bernat","last_name":"Corominas-Murtra","orcid":"0000-0001-9806-5643","first_name":"Bernat"},{"first_name":"Saskia I. J.","full_name":"Ellenbroek, Saskia I. J.","last_name":"Ellenbroek"},{"first_name":"Lotte","full_name":"Bruens, Lotte","last_name":"Bruens"},{"last_name":"Webb","full_name":"Webb, Anna T.","first_name":"Anna T."},{"first_name":"Dimitrios","last_name":"Laskaris","full_name":"Laskaris, Dimitrios"},{"full_name":"Oost, Koen C.","last_name":"Oost","first_name":"Koen C."},{"full_name":"Lafirenze, Simona J. A.","last_name":"Lafirenze","first_name":"Simona J. A."},{"first_name":"Karl","last_name":"Annusver","full_name":"Annusver, Karl"},{"last_name":"Messal","full_name":"Messal, Hendrik A.","first_name":"Hendrik A."},{"first_name":"Sharif","full_name":"Iqbal, Sharif","last_name":"Iqbal"},{"first_name":"Dustin J.","full_name":"Flanagan, Dustin J.","last_name":"Flanagan"},{"first_name":"David J.","full_name":"Huels, David J.","last_name":"Huels"},{"first_name":"Felipe","full_name":"Rojas-Rodríguez, Felipe","last_name":"Rojas-Rodríguez"},{"first_name":"Miguel","last_name":"Vizoso","full_name":"Vizoso, Miguel"},{"first_name":"Maria","last_name":"Kasper","full_name":"Kasper, Maria"},{"full_name":"Sansom, Owen J.","last_name":"Sansom","first_name":"Owen J."},{"full_name":"Snippert, Hugo J.","last_name":"Snippert","first_name":"Hugo J."},{"full_name":"Liberali, Prisca","last_name":"Liberali","first_name":"Prisca"},{"full_name":"Simons, Benjamin D.","last_name":"Simons","first_name":"Benjamin D."},{"full_name":"Katajisto, Pekka","last_name":"Katajisto","first_name":"Pekka"},{"first_name":"Edouard B","orcid":"0000-0001-6005-1561","last_name":"Hannezo","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Jacco","full_name":"van Rheenen, Jacco","last_name":"van Rheenen"}],"keyword":["Multidisciplinary"],"publication_status":"published","citation":{"chicago":"Azkanaz, Maria, Bernat Corominas-Murtra, Saskia I. J. Ellenbroek, Lotte Bruens, Anna T. Webb, Dimitrios Laskaris, Koen C. Oost, et al. “Retrograde Movements Determine Effective Stem Cell Numbers in the Intestine.” <i>Nature</i>. Springer Nature, 2022. <a href=\"https://doi.org/10.1038/s41586-022-04962-0\">https://doi.org/10.1038/s41586-022-04962-0</a>.","apa":"Azkanaz, M., Corominas-Murtra, B., Ellenbroek, S. I. J., Bruens, L., Webb, A. T., Laskaris, D., … van Rheenen, J. (2022). Retrograde movements determine effective stem cell numbers in the intestine. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-022-04962-0\">https://doi.org/10.1038/s41586-022-04962-0</a>","ieee":"M. Azkanaz <i>et al.</i>, “Retrograde movements determine effective stem cell numbers in the intestine,” <i>Nature</i>, vol. 607, no. 7919. Springer Nature, pp. 548–554, 2022.","ista":"Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo EB, van Rheenen J. 2022. Retrograde movements determine effective stem cell numbers in the intestine. Nature. 607(7919), 548–554.","short":"M. Azkanaz, B. Corominas-Murtra, S.I.J. Ellenbroek, L. Bruens, A.T. Webb, D. Laskaris, K.C. Oost, S.J.A. Lafirenze, K. Annusver, H.A. Messal, S. Iqbal, D.J. Flanagan, D.J. Huels, F. Rojas-Rodríguez, M. Vizoso, M. Kasper, O.J. Sansom, H.J. Snippert, P. Liberali, B.D. Simons, P. Katajisto, E.B. Hannezo, J. van Rheenen, Nature 607 (2022) 548–554.","ama":"Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, et al. Retrograde movements determine effective stem cell numbers in the intestine. <i>Nature</i>. 2022;607(7919):548-554. doi:<a href=\"https://doi.org/10.1038/s41586-022-04962-0\">10.1038/s41586-022-04962-0</a>","mla":"Azkanaz, Maria, et al. “Retrograde Movements Determine Effective Stem Cell Numbers in the Intestine.” <i>Nature</i>, vol. 607, no. 7919, Springer Nature, 2022, pp. 548–54, doi:<a href=\"https://doi.org/10.1038/s41586-022-04962-0\">10.1038/s41586-022-04962-0</a>."},"pmid":1,"_id":"12274","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"acknowledgement":"We thank the members of the van Rheenen laboratory for reading the manuscript, and the members of the bioimaging, FACS and animal facility of the NKI for experimental support. We acknowledge the staff at the MedH Flow Cytometry core facility, Karolinska Institutet, and LCI facility/Nikon Center of Excellence, Karolinska Institutet. This work was financially supported by the Netherlands Organization of Scientific Research NWO (Veni grant 863.15.011 to S.I.J.E. and Vici grant 09150182110004 to J.v.R.) and the CancerGenomics.nl (Netherlands Organisation for Scientific Research) program (to J.v.R.) the Doctor Josef Steiner Foundation (to J.v.R). B.D.S. acknowledges funding from the Royal Society E.P. Abraham Research Professorship (RP\\R1\\180165) and the Wellcome Trust (098357/Z/12/Z and 219478/Z/19/Z). B.C.-M. acknowledges the support of the field of excellence ‘Complexity of life in basic research and innovation’ of the University of Graz. O.J.S. and their laboratory acknowledge CRUK core funding to the CRUK Beatson Institute (A17196 and A31287) and CRUK core funding to the Sansom laboratory (A21139). P.K. and their laboratory are supported by grants from the Swedish Research Council (2018-03078), Cancerfonden (190634), Academy of Finland Centre of Excellence (266869, 304591 and 320185) and the Jane and Aatos Erkko Foundation. P.L. has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 758617). E.H. acknowledges funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement no. 851288).","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","project":[{"grant_number":"851288","call_identifier":"H2020","_id":"05943252-7A3F-11EA-A408-12923DDC885E","name":"Design Principles of Branching Morphogenesis"}],"oa_version":"Submitted Version","volume":607,"date_updated":"2023-10-03T11:16:30Z","oa":1,"article_processing_charge":"No"},{"author":[{"first_name":"Achille","last_name":"Jouberton","full_name":"Jouberton, Achille"},{"first_name":"Thomas E.","last_name":"Shaw","full_name":"Shaw, Thomas E."},{"first_name":"Evan","last_name":"Miles","full_name":"Miles, Evan"},{"last_name":"McCarthy","full_name":"McCarthy, Michael","first_name":"Michael"},{"last_name":"Fugger","full_name":"Fugger, Stefan","first_name":"Stefan"},{"first_name":"Shaoting","full_name":"Ren, Shaoting","last_name":"Ren"},{"last_name":"Dehecq","full_name":"Dehecq, Amaury","first_name":"Amaury"},{"first_name":"Wei","full_name":"Yang, Wei","last_name":"Yang"},{"id":"b28f055a-81ea-11ed-b70c-a9fe7f7b0e70","last_name":"Pellicciotti","full_name":"Pellicciotti, Francesca","first_name":"Francesca"}],"keyword":["Multidisciplinary"],"abstract":[{"text":"Glaciers are key components of the mountain water towers of Asia and are vital for downstream domestic, agricultural, and industrial uses. The glacier mass loss rate over the southeastern Tibetan Plateau is among the highest in Asia and has accelerated in recent decades. This acceleration has been attributed to increased warming, but the mechanisms behind these glaciers’ high sensitivity to warming remain unclear, while the influence of changes in precipitation over the past decades is poorly quantified. Here, we reconstruct glacier mass changes and catchment runoff since 1975 at a benchmark glacier, Parlung No. 4, to shed light on the drivers of recent mass losses for the monsoonal, spring-accumulation glaciers of the Tibetan Plateau. Our modeling demonstrates how a temperature increase (mean of 0.39<jats:sup>∘</jats:sup>C ⋅dec<jats:sup>−1</jats:sup>since 1990) has accelerated mass loss rates by altering both the ablation and accumulation regimes in a complex manner. The majority of the post-2000 mass loss occurred during the monsoon months, caused by simultaneous decreases in the solid precipitation ratio (from 0.70 to 0.56) and precipitation amount (–10%), leading to reduced monsoon accumulation (–26%). Higher solid precipitation in spring (+18%) during the last two decades was increasingly important in mitigating glacier mass loss by providing mass to the glacier and protecting it from melting in the early monsoon. With bare ice exposed to warmer temperatures for longer periods, icemelt and catchment discharge have unsustainably intensified since the start of the 21st century, raising concerns for long-term water supply and hazard occurrence in the region.","lang":"eng"}],"publication_status":"published","citation":{"ieee":"A. Jouberton <i>et al.</i>, “Warming-induced monsoon precipitation phase change intensifies glacier mass loss in the southeastern Tibetan Plateau,” <i>PNAS</i>, vol. 119, no. 37. Proceedings of the National Academy of Sciences, 2022.","apa":"Jouberton, A., Shaw, T. E., Miles, E., McCarthy, M., Fugger, S., Ren, S., … Pellicciotti, F. (2022). Warming-induced monsoon precipitation phase change intensifies glacier mass loss in the southeastern Tibetan Plateau. <i>PNAS</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2109796119\">https://doi.org/10.1073/pnas.2109796119</a>","chicago":"Jouberton, Achille, Thomas E. Shaw, Evan Miles, Michael McCarthy, Stefan Fugger, Shaoting Ren, Amaury Dehecq, Wei Yang, and Francesca Pellicciotti. “Warming-Induced Monsoon Precipitation Phase Change Intensifies Glacier Mass Loss in the Southeastern Tibetan Plateau.” <i>PNAS</i>. Proceedings of the National Academy of Sciences, 2022. <a href=\"https://doi.org/10.1073/pnas.2109796119\">https://doi.org/10.1073/pnas.2109796119</a>.","mla":"Jouberton, Achille, et al. “Warming-Induced Monsoon Precipitation Phase Change Intensifies Glacier Mass Loss in the Southeastern Tibetan Plateau.” <i>PNAS</i>, vol. 119, no. 37, e2109796119, Proceedings of the National Academy of Sciences, 2022, doi:<a href=\"https://doi.org/10.1073/pnas.2109796119\">10.1073/pnas.2109796119</a>.","ama":"Jouberton A, Shaw TE, Miles E, et al. Warming-induced monsoon precipitation phase change intensifies glacier mass loss in the southeastern Tibetan Plateau. <i>PNAS</i>. 2022;119(37). doi:<a href=\"https://doi.org/10.1073/pnas.2109796119\">10.1073/pnas.2109796119</a>","short":"A. Jouberton, T.E. Shaw, E. Miles, M. McCarthy, S. Fugger, S. Ren, A. Dehecq, W. Yang, F. Pellicciotti, PNAS 119 (2022).","ista":"Jouberton A, Shaw TE, Miles E, McCarthy M, Fugger S, Ren S, Dehecq A, Yang W, Pellicciotti F. 2022. Warming-induced monsoon precipitation phase change intensifies glacier mass loss in the southeastern Tibetan Plateau. PNAS. 119(37), e2109796119."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","oa_version":"None","_id":"12577","extern":"1","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"date_updated":"2023-02-28T13:50:37Z","volume":119,"article_processing_charge":"No","title":"Warming-induced monsoon precipitation phase change intensifies glacier mass loss in the southeastern Tibetan Plateau","year":"2022","doi":"10.1073/pnas.2109796119","article_number":"e2109796119","status":"public","intvolume":"       119","type":"journal_article","day":"06","issue":"37","publication":"PNAS","language":[{"iso":"eng"}],"publisher":"Proceedings of the National Academy of Sciences","scopus_import":"1","article_type":"original","date_published":"2022-09-06T00:00:00Z","month":"09","date_created":"2023-02-20T08:10:02Z"},{"page":"678-679","issue":"6530","publication":"Science","type":"journal_article","day":"12","status":"public","intvolume":"       371","department":[{"_id":"MaIb"}],"date_created":"2022-03-03T09:51:48Z","article_type":"letter_note","date_published":"2021-02-12T00:00:00Z","month":"02","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","scopus_import":"1","date_updated":"2023-08-17T07:00:35Z","volume":371,"article_processing_charge":"No","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","quality_controlled":"1","oa_version":"None","pmid":1,"_id":"10809","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"publication_status":"published","citation":{"chicago":"Liu, Yu, and Maria Ibáñez. “Tidying up the Mess.” <i>Science</i>. American Association for the Advancement of Science, 2021. <a href=\"https://doi.org/10.1126/science.abg0886\">https://doi.org/10.1126/science.abg0886</a>.","apa":"Liu, Y., &#38; Ibáñez, M. (2021). Tidying up the mess. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abg0886\">https://doi.org/10.1126/science.abg0886</a>","ieee":"Y. Liu and M. Ibáñez, “Tidying up the mess,” <i>Science</i>, vol. 371, no. 6530. American Association for the Advancement of Science, pp. 678–679, 2021.","short":"Y. Liu, M. Ibáñez, Science 371 (2021) 678–679.","ista":"Liu Y, Ibáñez M. 2021. Tidying up the mess. Science. 371(6530), 678–679.","ama":"Liu Y, Ibáñez M. Tidying up the mess. <i>Science</i>. 2021;371(6530):678-679. doi:<a href=\"https://doi.org/10.1126/science.abg0886\">10.1126/science.abg0886</a>","mla":"Liu, Yu, and Maria Ibáñez. “Tidying up the Mess.” <i>Science</i>, vol. 371, no. 6530, American Association for the Advancement of Science, 2021, pp. 678–79, doi:<a href=\"https://doi.org/10.1126/science.abg0886\">10.1126/science.abg0886</a>."},"author":[{"id":"2A70014E-F248-11E8-B48F-1D18A9856A87","first_name":"Yu","orcid":"0000-0001-7313-6740","full_name":"Liu, Yu","last_name":"Liu"},{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","orcid":"0000-0001-5013-2843","last_name":"Ibáñez","full_name":"Ibáñez, Maria"}],"keyword":["multidisciplinary"],"abstract":[{"text":"Thermoelectric materials are engines that convert heat into an electrical current. Intuitively, the efficiency of this process depends on how many electrons (charge carriers) can move and how easily they do so, how much energy those moving electrons transport, and how easily the temperature gradient is maintained. In terms of material properties, an excellent thermoelectric material requires a high electrical conductivity σ, a high Seebeck coefficient S (a measure of the induced thermoelectric voltage as a function of temperature gradient), and a low thermal conductivity κ. The challenge is that these three properties are strongly interrelated in a conflicting manner (1). On page 722 of this issue, Roychowdhury et al. (2) have found a way to partially break these ties in silver antimony telluride (AgSbTe2) with the addition of cadmium (Cd) cations, which increase the ordering in this inherently disordered thermoelectric material.","lang":"eng"}],"isi":1,"doi":"10.1126/science.abg0886","year":"2021","title":"Tidying up the mess","external_id":{"pmid":["33574201"],"isi":["000617551600027"]}},{"article_number":"abj8121","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1126/sciadv.abj8121"}],"year":"2021","doi":"10.1126/sciadv.abj8121","external_id":{"pmid":["34860540"]},"title":"Attosecond interferometry of shape resonances in the recoil frame of CF4","oa":1,"date_updated":"2023-08-22T07:30:25Z","volume":7,"article_processing_charge":"No","_id":"13995","pmid":1,"publication_identifier":{"eissn":["2375-2548"]},"extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","quality_controlled":"1","publication_status":"published","citation":{"ieee":"S. Heck <i>et al.</i>, “Attosecond interferometry of shape resonances in the recoil frame of CF4,” <i>Science Advances</i>, vol. 7, no. 49. American Association for the Advancement of Science, 2021.","apa":"Heck, S., Baykusheva, D. R., Han, M., Ji, J.-B., Perry, C., Gong, X., &#38; Wörner, H. J. (2021). Attosecond interferometry of shape resonances in the recoil frame of CF4. <i>Science Advances</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/sciadv.abj8121\">https://doi.org/10.1126/sciadv.abj8121</a>","chicago":"Heck, Saijoscha, Denitsa Rangelova Baykusheva, Meng Han, Jia-Bao Ji, Conaill Perry, Xiaochun Gong, and Hans Jakob Wörner. “Attosecond Interferometry of Shape Resonances in the Recoil Frame of CF4.” <i>Science Advances</i>. American Association for the Advancement of Science, 2021. <a href=\"https://doi.org/10.1126/sciadv.abj8121\">https://doi.org/10.1126/sciadv.abj8121</a>.","mla":"Heck, Saijoscha, et al. “Attosecond Interferometry of Shape Resonances in the Recoil Frame of CF4.” <i>Science Advances</i>, vol. 7, no. 49, abj8121, American Association for the Advancement of Science, 2021, doi:<a href=\"https://doi.org/10.1126/sciadv.abj8121\">10.1126/sciadv.abj8121</a>.","ama":"Heck S, Baykusheva DR, Han M, et al. Attosecond interferometry of shape resonances in the recoil frame of CF4. <i>Science Advances</i>. 2021;7(49). doi:<a href=\"https://doi.org/10.1126/sciadv.abj8121\">10.1126/sciadv.abj8121</a>","ista":"Heck S, Baykusheva DR, Han M, Ji J-B, Perry C, Gong X, Wörner HJ. 2021. Attosecond interferometry of shape resonances in the recoil frame of CF4. Science Advances. 7(49), abj8121.","short":"S. Heck, D.R. Baykusheva, M. Han, J.-B. Ji, C. Perry, X. Gong, H.J. Wörner, Science Advances 7 (2021)."},"abstract":[{"lang":"eng","text":"Shape resonances play a central role in many areas of science, but the real-time measurement of the associated many-body dynamics remains challenging. Here, we present measurements of recoil frame angle-resolved photoionization delays in the vicinity of shape resonances of CF4. This technique provides insights into the spatiotemporal photoionization dynamics of molecular shape resonances. We find delays of up to ∼600 as in the ionization out of the highest occupied molecular orbital (HOMO) with a strong dependence on the emission direction and a pronounced asymmetry along the dissociation axis. Comparison with quantum-scattering calculations traces the asymmetries to the interference of a small subset of partial waves at low kinetic energies and, additionally, to the interference of two overlapping shape resonances in the HOMO-1 channel. Our experimental and theoretical results establish a broadly applicable approach to space- and time-resolved photoionization dynamics in the molecular frame."}],"keyword":["Multidisciplinary"],"author":[{"first_name":"Saijoscha","last_name":"Heck","full_name":"Heck, Saijoscha"},{"first_name":"Denitsa Rangelova","full_name":"Baykusheva, Denitsa Rangelova","last_name":"Baykusheva","id":"71b4d059-2a03-11ee-914d-dfa3beed6530"},{"last_name":"Han","full_name":"Han, Meng","first_name":"Meng"},{"first_name":"Jia-Bao","last_name":"Ji","full_name":"Ji, Jia-Bao"},{"last_name":"Perry","full_name":"Perry, Conaill","first_name":"Conaill"},{"full_name":"Gong, Xiaochun","last_name":"Gong","first_name":"Xiaochun"},{"full_name":"Wörner, Hans Jakob","last_name":"Wörner","first_name":"Hans Jakob"}],"date_created":"2023-08-09T13:09:02Z","month":"12","article_type":"original","date_published":"2021-12-03T00:00:00Z","publisher":"American Association for the Advancement of Science","scopus_import":"1","language":[{"iso":"eng"}],"issue":"49","publication":"Science Advances","day":"03","type":"journal_article","intvolume":"         7","status":"public"}]