[{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/lsa.2016.170"}],"oa":1,"publication_identifier":{"eissn":["2047-7538"]},"date_published":"2016-11-01T00:00:00Z","type":"journal_article","language":[{"iso":"eng"}],"keyword":["Atomic and Molecular Physics","and Optics","Electronic","Optical and Magnetic Materials"],"month":"11","oa_version":"Published Version","publication":"Light: Science & Applications","extern":"1","volume":5,"abstract":[{"text":"Monochromatization of high-harmonic sources has opened fascinating perspectives regarding time-resolved photoemission from all phases of matter. Such studies have invariably involved the use of spectral filters or spectrally dispersive optical components that are inherently lossy and technically complex. Here we present a new technique for the spectral selection of near-threshold harmonics and their spatial separation from the driving beams without any optical elements. We discover the existence of a narrow phase-matching gate resulting from the combination of the non-collinear generation geometry in an extended medium, atomic resonances and absorption. Our technique offers a filter contrast of up to 104 for the selected harmonics against the adjacent ones and offers multiple temporally synchronized beamlets in a single unified scheme. We demonstrate the selective generation of 133, 80 or 56 nm femtosecond pulses from a 400-nm driver, which is specific to the target gas. These results open new pathways towards phase-sensitive multi-pulse spectroscopy in the vacuum- and extreme-ultraviolet, and frequency-selective output coupling from enhancement cavities.","lang":"eng"}],"doi":"10.1038/lsa.2016.170","day":"01","external_id":{"pmid":["30167130"]},"date_updated":"2023-08-22T08:46:05Z","citation":{"ista":"Rajeev R, Hellwagner J, Schumacher A, Jordan I, Huppert M, Tehlar A, Niraghatam BR, Baykusheva DR, Lin N, von Conta A, Wörner HJ. 2016. In situ frequency gating and beam splitting of vacuum- and extreme-ultraviolet pulses. Light: Science &#38; Applications. 5(11), e16170–e16170.","short":"R. Rajeev, J. Hellwagner, A. Schumacher, I. Jordan, M. Huppert, A. Tehlar, B.R. Niraghatam, D.R. Baykusheva, N. Lin, A. von Conta, H.J. Wörner, Light: Science &#38; Applications 5 (2016) e16170–e16170.","mla":"Rajeev, Rajendran, et al. “In Situ Frequency Gating and Beam Splitting of Vacuum- and Extreme-Ultraviolet Pulses.” <i>Light: Science &#38; Applications</i>, vol. 5, no. 11, Springer Nature, 2016, pp. e16170–e16170, doi:<a href=\"https://doi.org/10.1038/lsa.2016.170\">10.1038/lsa.2016.170</a>.","ieee":"R. Rajeev <i>et al.</i>, “In situ frequency gating and beam splitting of vacuum- and extreme-ultraviolet pulses,” <i>Light: Science &#38; Applications</i>, vol. 5, no. 11. Springer Nature, pp. e16170–e16170, 2016.","chicago":"Rajeev, Rajendran, Johannes Hellwagner, Anne Schumacher, Inga Jordan, Martin Huppert, Andres Tehlar, Bhargava Ram Niraghatam, et al. “In Situ Frequency Gating and Beam Splitting of Vacuum- and Extreme-Ultraviolet Pulses.” <i>Light: Science &#38; Applications</i>. Springer Nature, 2016. <a href=\"https://doi.org/10.1038/lsa.2016.170\">https://doi.org/10.1038/lsa.2016.170</a>.","ama":"Rajeev R, Hellwagner J, Schumacher A, et al. In situ frequency gating and beam splitting of vacuum- and extreme-ultraviolet pulses. <i>Light: Science &#38; Applications</i>. 2016;5(11):e16170-e16170. doi:<a href=\"https://doi.org/10.1038/lsa.2016.170\">10.1038/lsa.2016.170</a>","apa":"Rajeev, R., Hellwagner, J., Schumacher, A., Jordan, I., Huppert, M., Tehlar, A., … Wörner, H. J. (2016). In situ frequency gating and beam splitting of vacuum- and extreme-ultraviolet pulses. <i>Light: Science &#38; Applications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/lsa.2016.170\">https://doi.org/10.1038/lsa.2016.170</a>"},"year":"2016","article_type":"original","publisher":"Springer Nature","page":"e16170-e16170","quality_controlled":"1","title":"In situ frequency gating and beam splitting of vacuum- and extreme-ultraviolet pulses","intvolume":"         5","publication_status":"published","article_processing_charge":"No","date_created":"2023-08-10T06:37:25Z","author":[{"last_name":"Rajeev","first_name":"Rajendran","full_name":"Rajeev, Rajendran"},{"full_name":"Hellwagner, Johannes","first_name":"Johannes","last_name":"Hellwagner"},{"last_name":"Schumacher","first_name":"Anne","full_name":"Schumacher, Anne"},{"first_name":"Inga","last_name":"Jordan","full_name":"Jordan, Inga"},{"first_name":"Martin","last_name":"Huppert","full_name":"Huppert, Martin"},{"full_name":"Tehlar, Andres","first_name":"Andres","last_name":"Tehlar"},{"first_name":"Bhargava Ram","last_name":"Niraghatam","full_name":"Niraghatam, Bhargava Ram"},{"id":"71b4d059-2a03-11ee-914d-dfa3beed6530","last_name":"Baykusheva","first_name":"Denitsa Rangelova","full_name":"Baykusheva, Denitsa Rangelova"},{"first_name":"Nan","last_name":"Lin","full_name":"Lin, Nan"},{"full_name":"von Conta, Aaron","first_name":"Aaron","last_name":"von Conta"},{"full_name":"Wörner, Hans Jakob","last_name":"Wörner","first_name":"Hans Jakob"}],"issue":"11","pmid":1,"_id":"14012","scopus_import":"1"},{"scopus_import":"1","_id":"11073","pmid":1,"issue":"7","author":[{"full_name":"Hatch, Emily M.","last_name":"Hatch","first_name":"Emily M."},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"}],"article_processing_charge":"No","date_created":"2022-04-07T07:48:49Z","publication_status":"published","intvolume":"       161","title":"Linking micronuclei to chromosome fragmentation","quality_controlled":"1","page":"1502-1504","publisher":"Elsevier","article_type":"original","citation":{"ama":"Hatch EM, Hetzer M. Linking micronuclei to chromosome fragmentation. <i>Cell</i>. 2015;161(7):1502-1504. doi:<a href=\"https://doi.org/10.1016/j.cell.2015.06.005\">10.1016/j.cell.2015.06.005</a>","apa":"Hatch, E. M., &#38; Hetzer, M. (2015). Linking micronuclei to chromosome fragmentation. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2015.06.005\">https://doi.org/10.1016/j.cell.2015.06.005</a>","ieee":"E. M. Hatch and M. Hetzer, “Linking micronuclei to chromosome fragmentation,” <i>Cell</i>, vol. 161, no. 7. Elsevier, pp. 1502–1504, 2015.","chicago":"Hatch, Emily M., and Martin Hetzer. “Linking Micronuclei to Chromosome Fragmentation.” <i>Cell</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.cell.2015.06.005\">https://doi.org/10.1016/j.cell.2015.06.005</a>.","mla":"Hatch, Emily M., and Martin Hetzer. “Linking Micronuclei to Chromosome Fragmentation.” <i>Cell</i>, vol. 161, no. 7, Elsevier, 2015, pp. 1502–04, doi:<a href=\"https://doi.org/10.1016/j.cell.2015.06.005\">10.1016/j.cell.2015.06.005</a>.","short":"E.M. Hatch, M. Hetzer, Cell 161 (2015) 1502–1504.","ista":"Hatch EM, Hetzer M. 2015. Linking micronuclei to chromosome fragmentation. Cell. 161(7), 1502–1504."},"year":"2015","date_updated":"2022-07-18T08:34:33Z","external_id":{"pmid":["26091034"]},"day":"18","doi":"10.1016/j.cell.2015.06.005","abstract":[{"lang":"eng","text":"Human cancer cells bear complex chromosome rearrangements that can be potential drivers of cancer development. However, the molecular mechanisms underlying these rearrangements have been unclear. Zhang et al. use a new technique combining live-cell imaging and single-cell sequencing to demonstrate that chromosomes mis-segregated to micronuclei frequently undergo chromothripsis-like rearrangements in the subsequent cell cycle."}],"volume":161,"extern":"1","publication":"Cell","oa_version":"Published Version","month":"06","keyword":["General Biochemistry","Genetics and Molecular Biology"],"language":[{"iso":"eng"}],"type":"journal_article","date_published":"2015-06-18T00:00:00Z","publication_identifier":{"issn":["0092-8674"]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.1016/j.cell.2015.06.005","open_access":"1"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public"},{"day":"18","doi":"10.1016/j.cub.2015.02.033","year":"2015","citation":{"ieee":"E. M. Hatch and M. Hetzer, “Chromothripsis,” <i>Current Biology</i>, vol. 25, no. 10. Elsevier, pp. PR397-R399, 2015.","chicago":"Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” <i>Current Biology</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.cub.2015.02.033\">https://doi.org/10.1016/j.cub.2015.02.033</a>.","ama":"Hatch EM, Hetzer M. Chromothripsis. <i>Current Biology</i>. 2015;25(10):PR397-R399. doi:<a href=\"https://doi.org/10.1016/j.cub.2015.02.033\">10.1016/j.cub.2015.02.033</a>","apa":"Hatch, E. M., &#38; Hetzer, M. (2015). Chromothripsis. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2015.02.033\">https://doi.org/10.1016/j.cub.2015.02.033</a>","ista":"Hatch EM, Hetzer M. 2015. Chromothripsis. Current Biology. 25(10), PR397-R399.","mla":"Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” <i>Current Biology</i>, vol. 25, no. 10, Elsevier, 2015, pp. PR397-R399, doi:<a href=\"https://doi.org/10.1016/j.cub.2015.02.033\">10.1016/j.cub.2015.02.033</a>.","short":"E.M. Hatch, M. Hetzer, Current Biology 25 (2015) PR397-R399."},"date_updated":"2022-07-18T08:34:34Z","external_id":{"pmid":["25989073"]},"volume":25,"extern":"1","date_created":"2022-04-07T07:49:00Z","article_processing_charge":"No","publication_status":"published","intvolume":"        25","title":"Chromothripsis","scopus_import":"1","pmid":1,"_id":"11074","issue":"10","author":[{"full_name":"Hatch, Emily M.","first_name":"Emily M.","last_name":"Hatch"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER"}],"publisher":"Elsevier","article_type":"original","quality_controlled":"1","page":"PR397-R399","publication_identifier":{"issn":["0960-9822"]},"oa":1,"type":"journal_article","date_published":"2015-05-18T00:00:00Z","main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2015.02.033","open_access":"1"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public","oa_version":"Published Version","month":"05","publication":"Current Biology","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"language":[{"iso":"eng"}]},{"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.stem.2015.09.001"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public","type":"journal_article","date_published":"2015-12-03T00:00:00Z","publication_identifier":{"issn":["1934-5909"]},"oa":1,"keyword":["Cell Biology","Genetics","Molecular Medicine"],"language":[{"iso":"eng"}],"publication":"Cell Stem Cell","oa_version":"Published Version","month":"12","volume":17,"extern":"1","year":"2015","citation":{"mla":"Mertens, Jerome, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” <i>Cell Stem Cell</i>, vol. 17, no. 6, Elsevier, 2015, pp. 705–18, doi:<a href=\"https://doi.org/10.1016/j.stem.2015.09.001\">10.1016/j.stem.2015.09.001</a>.","short":"J. Mertens, A.C.M. Paquola, M. Ku, E. Hatch, L. Böhnke, S. Ladjevardi, S. McGrath, B. Campbell, H. Lee, J.R. Herdy, J.T. Gonçalves, T. Toda, Y. Kim, J. Winkler, J. Yao, M. Hetzer, F.H. Gage, Cell Stem Cell 17 (2015) 705–718.","ista":"Mertens J, Paquola ACM, Ku M, Hatch E, Böhnke L, Ladjevardi S, McGrath S, Campbell B, Lee H, Herdy JR, Gonçalves JT, Toda T, Kim Y, Winkler J, Yao J, Hetzer M, Gage FH. 2015. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. Cell Stem Cell. 17(6), 705–718.","apa":"Mertens, J., Paquola, A. C. M., Ku, M., Hatch, E., Böhnke, L., Ladjevardi, S., … Gage, F. H. (2015). Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. <i>Cell Stem Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.stem.2015.09.001\">https://doi.org/10.1016/j.stem.2015.09.001</a>","ama":"Mertens J, Paquola ACM, Ku M, et al. Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects. <i>Cell Stem Cell</i>. 2015;17(6):705-718. doi:<a href=\"https://doi.org/10.1016/j.stem.2015.09.001\">10.1016/j.stem.2015.09.001</a>","chicago":"Mertens, Jerome, Apuã C.M. Paquola, Manching Ku, Emily Hatch, Lena Böhnke, Shauheen Ladjevardi, Sean McGrath, et al. “Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects.” <i>Cell Stem Cell</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.stem.2015.09.001\">https://doi.org/10.1016/j.stem.2015.09.001</a>.","ieee":"J. Mertens <i>et al.</i>, “Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects,” <i>Cell Stem Cell</i>, vol. 17, no. 6. Elsevier, pp. 705–718, 2015."},"date_updated":"2022-07-18T08:44:21Z","external_id":{"pmid":["26456686"]},"day":"03","doi":"10.1016/j.stem.2015.09.001","abstract":[{"lang":"eng","text":"Aging is a major risk factor for many human diseases, and in vitro generation of human neurons is an attractive approach for modeling aging-related brain disorders. However, modeling aging in differentiated human neurons has proved challenging. We generated neurons from human donors across a broad range of ages, either by iPSC-based reprogramming and differentiation or by direct conversion into induced neurons (iNs). While iPSCs and derived neurons did not retain aging-associated gene signatures, iNs displayed age-specific transcriptional profiles and revealed age-associated decreases in the nuclear transport receptor RanBP17. We detected an age-dependent loss of nucleocytoplasmic compartmentalization (NCC) in donor fibroblasts and corresponding iNs and found that reduced RanBP17 impaired NCC in young cells, while iPSC rejuvenation restored NCC in aged cells. These results show that iNs retain important aging-related signatures, thus allowing modeling of the aging process in vitro, and they identify impaired NCC as an important factor in human aging."}],"quality_controlled":"1","page":"705-718","publisher":"Elsevier","article_type":"original","scopus_import":"1","_id":"11079","pmid":1,"issue":"6","author":[{"full_name":"Mertens, Jerome","last_name":"Mertens","first_name":"Jerome"},{"full_name":"Paquola, Apuã C.M.","first_name":"Apuã C.M.","last_name":"Paquola"},{"first_name":"Manching","last_name":"Ku","full_name":"Ku, Manching"},{"first_name":"Emily","last_name":"Hatch","full_name":"Hatch, Emily"},{"first_name":"Lena","last_name":"Böhnke","full_name":"Böhnke, Lena"},{"full_name":"Ladjevardi, Shauheen","first_name":"Shauheen","last_name":"Ladjevardi"},{"first_name":"Sean","last_name":"McGrath","full_name":"McGrath, Sean"},{"first_name":"Benjamin","last_name":"Campbell","full_name":"Campbell, Benjamin"},{"full_name":"Lee, Hyungjun","first_name":"Hyungjun","last_name":"Lee"},{"full_name":"Herdy, Joseph R.","last_name":"Herdy","first_name":"Joseph R."},{"full_name":"Gonçalves, J. Tiago","last_name":"Gonçalves","first_name":"J. Tiago"},{"last_name":"Toda","first_name":"Tomohisa","full_name":"Toda, Tomohisa"},{"last_name":"Kim","first_name":"Yongsung","full_name":"Kim, Yongsung"},{"last_name":"Winkler","first_name":"Jürgen","full_name":"Winkler, Jürgen"},{"last_name":"Yao","first_name":"Jun","full_name":"Yao, Jun"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W"},{"first_name":"Fred H.","last_name":"Gage","full_name":"Gage, Fred H."}],"date_created":"2022-04-07T07:49:51Z","article_processing_charge":"No","publication_status":"published","intvolume":"        17","title":"Directly reprogrammed human neurons retain aging-associated transcriptomic signatures and reveal age-related nucleocytoplasmic defects"},{"author":[{"full_name":"Ma, Peixiang","first_name":"Peixiang","last_name":"Ma"},{"first_name":"Yi","last_name":"Xue","full_name":"Xue, Yi"},{"last_name":"Coquelle","first_name":"Nicolas","full_name":"Coquelle, Nicolas"},{"full_name":"Haller, Jens D.","last_name":"Haller","first_name":"Jens D."},{"full_name":"Yuwen, Tairan","first_name":"Tairan","last_name":"Yuwen"},{"full_name":"Ayala, Isabel","last_name":"Ayala","first_name":"Isabel"},{"first_name":"Oleg","last_name":"Mikhailovskii","full_name":"Mikhailovskii, Oleg"},{"full_name":"Willbold, Dieter","last_name":"Willbold","first_name":"Dieter"},{"full_name":"Colletier, Jacques-Philippe","first_name":"Jacques-Philippe","last_name":"Colletier"},{"full_name":"Skrynnikov, Nikolai R.","last_name":"Skrynnikov","first_name":"Nikolai R."},{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul","orcid":"0000-0002-9350-7606","last_name":"Schanda","first_name":"Paul"}],"publication":"Nature Communications","_id":"8456","intvolume":"         6","article_number":"8361","month":"10","title":"Observing the overall rocking motion of a protein in a crystal","article_processing_charge":"No","date_created":"2020-09-18T10:07:36Z","oa_version":"Published Version","publication_status":"published","keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"language":[{"iso":"eng"}],"quality_controlled":"1","article_type":"original","publisher":"Springer Nature","type":"journal_article","date_published":"2015-10-05T00:00:00Z","year":"2015","citation":{"ista":"Ma P, Xue Y, Coquelle N, Haller JD, Yuwen T, Ayala I, Mikhailovskii O, Willbold D, Colletier J-P, Skrynnikov NR, Schanda P. 2015. Observing the overall rocking motion of a protein in a crystal. Nature Communications. 6, 8361.","short":"P. Ma, Y. Xue, N. Coquelle, J.D. Haller, T. Yuwen, I. Ayala, O. Mikhailovskii, D. Willbold, J.-P. Colletier, N.R. Skrynnikov, P. Schanda, Nature Communications 6 (2015).","mla":"Ma, Peixiang, et al. “Observing the Overall Rocking Motion of a Protein in a Crystal.” <i>Nature Communications</i>, vol. 6, 8361, Springer Nature, 2015, doi:<a href=\"https://doi.org/10.1038/ncomms9361\">10.1038/ncomms9361</a>.","ieee":"P. Ma <i>et al.</i>, “Observing the overall rocking motion of a protein in a crystal,” <i>Nature Communications</i>, vol. 6. Springer Nature, 2015.","chicago":"Ma, Peixiang, Yi Xue, Nicolas Coquelle, Jens D. Haller, Tairan Yuwen, Isabel Ayala, Oleg Mikhailovskii, et al. “Observing the Overall Rocking Motion of a Protein in a Crystal.” <i>Nature Communications</i>. Springer Nature, 2015. <a href=\"https://doi.org/10.1038/ncomms9361\">https://doi.org/10.1038/ncomms9361</a>.","ama":"Ma P, Xue Y, Coquelle N, et al. Observing the overall rocking motion of a protein in a crystal. <i>Nature Communications</i>. 2015;6. doi:<a href=\"https://doi.org/10.1038/ncomms9361\">10.1038/ncomms9361</a>","apa":"Ma, P., Xue, Y., Coquelle, N., Haller, J. D., Yuwen, T., Ayala, I., … Schanda, P. (2015). Observing the overall rocking motion of a protein in a crystal. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/ncomms9361\">https://doi.org/10.1038/ncomms9361</a>"},"date_updated":"2021-01-12T08:19:24Z","abstract":[{"lang":"eng","text":"The large majority of three-dimensional structures of biological macromolecules have been determined by X-ray diffraction of crystalline samples. High-resolution structure determination crucially depends on the homogeneity of the protein crystal. Overall ‘rocking’ motion of molecules in the crystal is expected to influence diffraction quality, and such motion may therefore affect the process of solving crystal structures. Yet, so far overall molecular motion has not directly been observed in protein crystals, and the timescale of such dynamics remains unclear. Here we use solid-state NMR, X-ray diffraction methods and μs-long molecular dynamics simulations to directly characterize the rigid-body motion of a protein in different crystal forms. For ubiquitin crystals investigated in this study we determine the range of possible correlation times of rocking motion, 0.1–100 μs. The amplitude of rocking varies from one crystal form to another and is correlated with the resolution obtainable in X-ray diffraction experiments."}],"publication_identifier":{"issn":["2041-1723"]},"day":"05","doi":"10.1038/ncomms9361","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","extern":"1","volume":6},{"scopus_import":"1","pmid":1,"_id":"13392","author":[{"last_name":"Zhao","first_name":"Hui","full_name":"Zhao, Hui"},{"last_name":"Sen","first_name":"Soumyo","full_name":"Sen, Soumyo"},{"full_name":"Udayabhaskararao, T.","first_name":"T.","last_name":"Udayabhaskararao"},{"last_name":"Sawczyk","first_name":"Michał","full_name":"Sawczyk, Michał"},{"first_name":"Kristina","last_name":"Kučanda","full_name":"Kučanda, Kristina"},{"full_name":"Manna, Debasish","first_name":"Debasish","last_name":"Manna"},{"first_name":"Pintu K.","last_name":"Kundu","full_name":"Kundu, Pintu K."},{"last_name":"Lee","first_name":"Ji-Woong","full_name":"Lee, Ji-Woong"},{"full_name":"Král, Petr","last_name":"Král","first_name":"Petr"},{"id":"8e84690e-1e48-11ed-a02b-a1e6fb8bb53b","full_name":"Klajn, Rafal","last_name":"Klajn","first_name":"Rafal"}],"date_created":"2023-08-01T09:44:04Z","article_processing_charge":"No","publication_status":"published","intvolume":"        11","title":"Reversible trapping and reaction acceleration within dynamically self-assembling nanoflasks","quality_controlled":"1","page":"82-88","publisher":"Springer Nature","article_type":"original","citation":{"ista":"Zhao H, Sen S, Udayabhaskararao T, Sawczyk M, Kučanda K, Manna D, Kundu PK, Lee J-W, Král P, Klajn R. 2015. Reversible trapping and reaction acceleration within dynamically self-assembling nanoflasks. Nature Nanotechnology. 11, 82–88.","short":"H. Zhao, S. Sen, T. Udayabhaskararao, M. Sawczyk, K. Kučanda, D. Manna, P.K. Kundu, J.-W. Lee, P. Král, R. Klajn, Nature Nanotechnology 11 (2015) 82–88.","mla":"Zhao, Hui, et al. “Reversible Trapping and Reaction Acceleration within Dynamically Self-Assembling Nanoflasks.” <i>Nature Nanotechnology</i>, vol. 11, Springer Nature, 2015, pp. 82–88, doi:<a href=\"https://doi.org/10.1038/nnano.2015.256\">10.1038/nnano.2015.256</a>.","ieee":"H. Zhao <i>et al.</i>, “Reversible trapping and reaction acceleration within dynamically self-assembling nanoflasks,” <i>Nature Nanotechnology</i>, vol. 11. Springer Nature, pp. 82–88, 2015.","chicago":"Zhao, Hui, Soumyo Sen, T. Udayabhaskararao, Michał Sawczyk, Kristina Kučanda, Debasish Manna, Pintu K. Kundu, Ji-Woong Lee, Petr Král, and Rafal Klajn. “Reversible Trapping and Reaction Acceleration within Dynamically Self-Assembling Nanoflasks.” <i>Nature Nanotechnology</i>. Springer Nature, 2015. <a href=\"https://doi.org/10.1038/nnano.2015.256\">https://doi.org/10.1038/nnano.2015.256</a>.","ama":"Zhao H, Sen S, Udayabhaskararao T, et al. Reversible trapping and reaction acceleration within dynamically self-assembling nanoflasks. <i>Nature Nanotechnology</i>. 2015;11:82-88. doi:<a href=\"https://doi.org/10.1038/nnano.2015.256\">10.1038/nnano.2015.256</a>","apa":"Zhao, H., Sen, S., Udayabhaskararao, T., Sawczyk, M., Kučanda, K., Manna, D., … Klajn, R. (2015). Reversible trapping and reaction acceleration within dynamically self-assembling nanoflasks. <i>Nature Nanotechnology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nnano.2015.256\">https://doi.org/10.1038/nnano.2015.256</a>"},"year":"2015","date_updated":"2023-08-07T12:55:46Z","external_id":{"pmid":["26595335"]},"day":"23","doi":"10.1038/nnano.2015.256","abstract":[{"text":"The chemical behaviour of molecules can be significantly modified by confinement to volumes comparable to the dimensions of the molecules. Although such confined spaces can be found in various nanostructured materials, such as zeolites, nanoporous organic frameworks and colloidal nanocrystal assemblies, the slow diffusion of molecules in and out of these materials has greatly hampered studying the effect of confinement on their physicochemical properties. Here, we show that this diffusion limitation can be overcome by reversibly creating and destroying confined environments by means of ultraviolet and visible light irradiation. We use colloidal nanocrystals functionalized with light-responsive ligands that readily self-assemble and trap various molecules from the surrounding bulk solution. Once trapped, these molecules can undergo chemical reactions with increased rates and with stereoselectivities significantly different from those in bulk solution. Illumination with visible light disassembles these nanoflasks, releasing the product in solution and thereby establishes a catalytic cycle. These dynamic nanoflasks can be useful for studying chemical reactivities in confined environments and for synthesizing molecules that are otherwise hard to achieve in bulk solution.","lang":"eng"}],"volume":11,"extern":"1","publication":"Nature Nanotechnology","oa_version":"None","month":"11","keyword":["Electrical and Electronic Engineering","Condensed Matter Physics","General Materials Science","Biomedical Engineering","Atomic and Molecular Physics","and Optics","Bioengineering"],"language":[{"iso":"eng"}],"type":"journal_article","date_published":"2015-11-23T00:00:00Z","publication_identifier":{"issn":["1748-3387"],"eissn":["1748-3395"]},"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"oa_version":"Published Version","month":"05","article_number":"7039","publication":"Nature Communications","main_file_link":[{"url":"https://doi.org/10.1038/ncomms8039","open_access":"1"}],"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2041-1723"]},"oa":1,"date_published":"2015-05-05T00:00:00Z","type":"journal_article","publisher":"Springer Nature","article_type":"original","quality_controlled":"1","publication_status":"published","date_created":"2023-08-10T06:38:01Z","article_processing_charge":"No","title":"Observation of laser-induced electronic structure in oriented polyatomic molecules","intvolume":"         6","pmid":1,"_id":"14016","scopus_import":"1","author":[{"full_name":"Kraus, P. M.","first_name":"P. M.","last_name":"Kraus"},{"full_name":"Tolstikhin, O. I.","first_name":"O. I.","last_name":"Tolstikhin"},{"id":"71b4d059-2a03-11ee-914d-dfa3beed6530","full_name":"Baykusheva, Denitsa Rangelova","last_name":"Baykusheva","first_name":"Denitsa Rangelova"},{"full_name":"Rupenyan, A.","last_name":"Rupenyan","first_name":"A."},{"full_name":"Schneider, J.","last_name":"Schneider","first_name":"J."},{"full_name":"Bisgaard, C. Z.","last_name":"Bisgaard","first_name":"C. Z."},{"last_name":"Morishita","first_name":"T.","full_name":"Morishita, T."},{"first_name":"F.","last_name":"Jensen","full_name":"Jensen, F."},{"full_name":"Madsen, L. B.","last_name":"Madsen","first_name":"L. B."},{"full_name":"Wörner, H. J.","last_name":"Wörner","first_name":"H. J."}],"volume":6,"extern":"1","doi":"10.1038/ncomms8039","day":"05","abstract":[{"lang":"eng","text":"All attosecond time-resolved measurements have so far relied on the use of intense near-infrared laser pulses. In particular, attosecond streaking, laser-induced electron diffraction and high-harmonic generation all make use of non-perturbative light–matter interactions. Remarkably, the effect of the strong laser field on the studied sample has often been neglected in previous studies. Here we use high-harmonic spectroscopy to measure laser-induced modifications of the electronic structure of molecules. We study high-harmonic spectra of spatially oriented CH3F and CH3Br as generic examples of polar polyatomic molecules. We accurately measure intensity ratios of even and odd-harmonic orders, and of the emission from aligned and unaligned molecules. We show that these robust observables reveal a substantial modification of the molecular electronic structure by the external laser field. Our insights offer new challenges and opportunities for a range of emerging strong-field attosecond spectroscopies."}],"date_updated":"2023-08-22T08:52:56Z","year":"2015","citation":{"ieee":"P. M. Kraus <i>et al.</i>, “Observation of laser-induced electronic structure in oriented polyatomic molecules,” <i>Nature Communications</i>, vol. 6. Springer Nature, 2015.","chicago":"Kraus, P. M., O. I. Tolstikhin, Denitsa Rangelova Baykusheva, A. Rupenyan, J. Schneider, C. Z. Bisgaard, T. Morishita, F. Jensen, L. B. Madsen, and H. J. Wörner. “Observation of Laser-Induced Electronic Structure in Oriented Polyatomic Molecules.” <i>Nature Communications</i>. Springer Nature, 2015. <a href=\"https://doi.org/10.1038/ncomms8039\">https://doi.org/10.1038/ncomms8039</a>.","apa":"Kraus, P. M., Tolstikhin, O. I., Baykusheva, D. R., Rupenyan, A., Schneider, J., Bisgaard, C. Z., … Wörner, H. J. (2015). Observation of laser-induced electronic structure in oriented polyatomic molecules. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/ncomms8039\">https://doi.org/10.1038/ncomms8039</a>","ama":"Kraus PM, Tolstikhin OI, Baykusheva DR, et al. Observation of laser-induced electronic structure in oriented polyatomic molecules. <i>Nature Communications</i>. 2015;6. doi:<a href=\"https://doi.org/10.1038/ncomms8039\">10.1038/ncomms8039</a>","ista":"Kraus PM, Tolstikhin OI, Baykusheva DR, Rupenyan A, Schneider J, Bisgaard CZ, Morishita T, Jensen F, Madsen LB, Wörner HJ. 2015. Observation of laser-induced electronic structure in oriented polyatomic molecules. Nature Communications. 6, 7039.","short":"P.M. Kraus, O.I. Tolstikhin, D.R. Baykusheva, A. Rupenyan, J. Schneider, C.Z. Bisgaard, T. Morishita, F. Jensen, L.B. Madsen, H.J. Wörner, Nature Communications 6 (2015).","mla":"Kraus, P. M., et al. “Observation of Laser-Induced Electronic Structure in Oriented Polyatomic Molecules.” <i>Nature Communications</i>, vol. 6, 7039, Springer Nature, 2015, doi:<a href=\"https://doi.org/10.1038/ncomms8039\">10.1038/ncomms8039</a>."},"external_id":{"pmid":["25940229"]}},{"publisher":"American Physical Society","article_type":"original","quality_controlled":"1","publication_status":"published","date_created":"2023-08-10T06:38:10Z","article_processing_charge":"No","title":"Theoretical study of molecular electronic and rotational coherences by high-order-harmonic generation","intvolume":"        91","_id":"14017","scopus_import":"1","author":[{"full_name":"Zhang, Song Bin","last_name":"Zhang","first_name":"Song Bin"},{"last_name":"Baykusheva","first_name":"Denitsa Rangelova","full_name":"Baykusheva, Denitsa Rangelova","id":"71b4d059-2a03-11ee-914d-dfa3beed6530"},{"full_name":"Kraus, Peter M.","last_name":"Kraus","first_name":"Peter M."},{"full_name":"Wörner, Hans Jakob","first_name":"Hans Jakob","last_name":"Wörner"},{"first_name":"Nina","last_name":"Rohringer","full_name":"Rohringer, Nina"}],"issue":"2","volume":91,"extern":"1","arxiv":1,"doi":"10.1103/physreva.91.023421","day":"19","abstract":[{"lang":"eng","text":"The detection of electron motion and electronic wave-packet dynamics is one of the core goals of attosecond science. Recently, choosing the nitric oxide molecule as an example, we have introduced and demonstrated an experimental approach to measure coupled valence electronic and rotational wave packets using high-order-harmonic-generation (HHG) spectroscopy [Kraus et al., Phys. Rev. Lett. 111, 243005 (2013)]. A short outline of the theory to describe the combination of the pump and HHG probe process was published together with an extensive discussion of experimental results [Baykusheva et al., Faraday Discuss. 171, 113 (2014)]. The comparison of theory and experiment showed good agreement on a quantitative level. Here, we present the theory in detail, which is based on a generalized density-matrix approach that describes the pump process and the subsequent probing of the wave packets by a semiclassical quantitative rescattering approach. An in-depth analysis of the different Raman scattering contributions to the creation of the coupled rotational and electronic spin-orbit wave packets is made. We present results for parallel and perpendicular linear polarizations of the pump and probe laser pulses. Furthermore, an analysis of the combined rotational-electronic density matrix in terms of irreducible components is presented that facilitates interpretation of the results."}],"date_updated":"2023-08-22T08:56:34Z","citation":{"mla":"Zhang, Song Bin, et al. “Theoretical Study of Molecular Electronic and Rotational Coherences by High-Order-Harmonic Generation.” <i>Physical Review A</i>, vol. 91, no. 2, 023421, American Physical Society, 2015, doi:<a href=\"https://doi.org/10.1103/physreva.91.023421\">10.1103/physreva.91.023421</a>.","short":"S.B. Zhang, D.R. Baykusheva, P.M. Kraus, H.J. Wörner, N. Rohringer, Physical Review A 91 (2015).","ista":"Zhang SB, Baykusheva DR, Kraus PM, Wörner HJ, Rohringer N. 2015. Theoretical study of molecular electronic and rotational coherences by high-order-harmonic generation. Physical Review A. 91(2), 023421.","ama":"Zhang SB, Baykusheva DR, Kraus PM, Wörner HJ, Rohringer N. Theoretical study of molecular electronic and rotational coherences by high-order-harmonic generation. <i>Physical Review A</i>. 2015;91(2). doi:<a href=\"https://doi.org/10.1103/physreva.91.023421\">10.1103/physreva.91.023421</a>","apa":"Zhang, S. B., Baykusheva, D. R., Kraus, P. M., Wörner, H. J., &#38; Rohringer, N. (2015). Theoretical study of molecular electronic and rotational coherences by high-order-harmonic generation. <i>Physical Review A</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physreva.91.023421\">https://doi.org/10.1103/physreva.91.023421</a>","chicago":"Zhang, Song Bin, Denitsa Rangelova Baykusheva, Peter M. Kraus, Hans Jakob Wörner, and Nina Rohringer. “Theoretical Study of Molecular Electronic and Rotational Coherences by High-Order-Harmonic Generation.” <i>Physical Review A</i>. American Physical Society, 2015. <a href=\"https://doi.org/10.1103/physreva.91.023421\">https://doi.org/10.1103/physreva.91.023421</a>.","ieee":"S. B. Zhang, D. R. Baykusheva, P. M. Kraus, H. J. Wörner, and N. Rohringer, “Theoretical study of molecular electronic and rotational coherences by high-order-harmonic generation,” <i>Physical Review A</i>, vol. 91, no. 2. American Physical Society, 2015."},"year":"2015","external_id":{"arxiv":["1504.03933"]},"language":[{"iso":"eng"}],"keyword":["Atomic and Molecular Physics","and Optics"],"oa_version":"Preprint","month":"02","article_number":"023421","publication":"Physical Review A","main_file_link":[{"url":"https://arxiv.org/abs/1504.03933","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","publication_identifier":{"issn":["1050-2947"],"eissn":["1094-1622"]},"oa":1,"date_published":"2015-02-19T00:00:00Z","type":"journal_article"},{"page":"868-869","quality_controlled":"1","publisher":"Elsevier","article_type":"original","pmid":1,"_id":"11080","scopus_import":"1","author":[{"full_name":"Buchwalter, Abigail","last_name":"Buchwalter","first_name":"Abigail"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W"}],"issue":"5","publication_status":"published","article_processing_charge":"No","date_created":"2022-04-07T07:50:04Z","title":"Nuclear pores set the speed limit for mitosis","intvolume":"       156","volume":156,"extern":"1","date_updated":"2022-07-18T08:44:33Z","year":"2014","citation":{"mla":"Buchwalter, Abigail, and Martin Hetzer. “Nuclear Pores Set the Speed Limit for Mitosis.” <i>Cell</i>, vol. 156, no. 5, Elsevier, 2014, pp. 868–69, doi:<a href=\"https://doi.org/10.1016/j.cell.2014.02.004\">10.1016/j.cell.2014.02.004</a>.","short":"A. Buchwalter, M. Hetzer, Cell 156 (2014) 868–869.","ista":"Buchwalter A, Hetzer M. 2014. Nuclear pores set the speed limit for mitosis. Cell. 156(5), 868–869.","ama":"Buchwalter A, Hetzer M. Nuclear pores set the speed limit for mitosis. <i>Cell</i>. 2014;156(5):868-869. doi:<a href=\"https://doi.org/10.1016/j.cell.2014.02.004\">10.1016/j.cell.2014.02.004</a>","apa":"Buchwalter, A., &#38; Hetzer, M. (2014). Nuclear pores set the speed limit for mitosis. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2014.02.004\">https://doi.org/10.1016/j.cell.2014.02.004</a>","chicago":"Buchwalter, Abigail, and Martin Hetzer. “Nuclear Pores Set the Speed Limit for Mitosis.” <i>Cell</i>. Elsevier, 2014. <a href=\"https://doi.org/10.1016/j.cell.2014.02.004\">https://doi.org/10.1016/j.cell.2014.02.004</a>.","ieee":"A. Buchwalter and M. Hetzer, “Nuclear pores set the speed limit for mitosis,” <i>Cell</i>, vol. 156, no. 5. Elsevier, pp. 868–869, 2014."},"external_id":{"pmid":["24581486"]},"doi":"10.1016/j.cell.2014.02.004","day":"27","abstract":[{"text":"The spindle assembly checkpoint prevents separation of sister chromatids until each kinetochore is attached to the mitotic spindle. Rodriguez-Bravo et al. report that the nuclear pore complex scaffolds spindle assembly checkpoint signaling in interphase, providing a store of inhibitory signals that limits the speed of the subsequent mitosis.","lang":"eng"}],"language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology"],"publication":"Cell","oa_version":"Published Version","month":"02","main_file_link":[{"url":"https://doi.org/10.1016/j.cell.2014.02.004","open_access":"1"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public","date_published":"2014-02-27T00:00:00Z","type":"journal_article","publication_identifier":{"issn":["0092-8674"]},"oa":1},{"volume":25,"extern":"1","year":"2014","citation":{"mla":"Buchwalter, Abigail L., et al. “Nup50 Is Required for Cell Differentiation and Exhibits Transcription-Dependent Dynamics.” <i>Molecular Biology of the Cell</i>, vol. 25, no. 16, American Society for Cell Biology, 2014, pp. 2472–84, doi:<a href=\"https://doi.org/10.1091/mbc.e14-04-0865\">10.1091/mbc.e14-04-0865</a>.","short":"A.L. Buchwalter, Y. Liang, M. Hetzer, Molecular Biology of the Cell 25 (2014) 2472–2484.","ista":"Buchwalter AL, Liang Y, Hetzer M. 2014. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Molecular Biology of the Cell. 25(16), 2472–2484.","ama":"Buchwalter AL, Liang Y, Hetzer M. Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. <i>Molecular Biology of the Cell</i>. 2014;25(16):2472-2484. doi:<a href=\"https://doi.org/10.1091/mbc.e14-04-0865\">10.1091/mbc.e14-04-0865</a>","apa":"Buchwalter, A. L., Liang, Y., &#38; Hetzer, M. (2014). Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. <i>Molecular Biology of the Cell</i>. American Society for Cell Biology. <a href=\"https://doi.org/10.1091/mbc.e14-04-0865\">https://doi.org/10.1091/mbc.e14-04-0865</a>","chicago":"Buchwalter, Abigail L., Yun Liang, and Martin Hetzer. “Nup50 Is Required for Cell Differentiation and Exhibits Transcription-Dependent Dynamics.” <i>Molecular Biology of the Cell</i>. American Society for Cell Biology, 2014. <a href=\"https://doi.org/10.1091/mbc.e14-04-0865\">https://doi.org/10.1091/mbc.e14-04-0865</a>.","ieee":"A. L. Buchwalter, Y. Liang, and M. Hetzer, “Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics,” <i>Molecular Biology of the Cell</i>, vol. 25, no. 16. American Society for Cell Biology, pp. 2472–2484, 2014."},"date_updated":"2022-07-18T08:45:20Z","day":"15","doi":"10.1091/mbc.e14-04-0865","abstract":[{"lang":"eng","text":"The nuclear pore complex (NPC) plays a critical role in gene expression by mediating import of transcription regulators into the nucleus and export of RNA transcripts to the cytoplasm. Emerging evidence suggests that in addition to mediating transport, a subset of nucleoporins (Nups) engage in transcriptional activation and elongation at genomic loci that are not associated with NPCs. The underlying mechanism and regulation of Nup mobility on and off nuclear pores remain unclear. Here we show that Nup50 is a mobile Nup with a pronounced presence both at the NPC and in the nucleoplasm that can move between these different localizations. Strikingly, the dynamic behavior of Nup50 in both locations is dependent on active transcription by RNA polymerase II and requires the N-terminal half of the protein, which contains importin α– and Nup153-binding domains. However, Nup50 dynamics are independent of importin α, Nup153, and Nup98, even though the latter two proteins also exhibit transcription-dependent mobility. Of interest, depletion of Nup50 from C2C12 myoblasts does not affect cell proliferation but inhibits differentiation into myotubes. Taken together, our results suggest a transport-independent role for Nup50 in chromatin biology that occurs away from the NPC."}],"quality_controlled":"1","page":"2472-2484","publisher":"American Society for Cell Biology","article_type":"original","scopus_import":"1","_id":"11082","issue":"16","author":[{"full_name":"Buchwalter, Abigail L.","last_name":"Buchwalter","first_name":"Abigail L."},{"full_name":"Liang, Yun","first_name":"Yun","last_name":"Liang"},{"orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","first_name":"Martin W","last_name":"HETZER","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"date_created":"2022-04-07T07:50:24Z","article_processing_charge":"No","publication_status":"published","intvolume":"        25","title":"Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics","main_file_link":[{"url":"https://doi.org/10.1091/mbc.e14-04-0865","open_access":"1"}],"status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","type":"journal_article","date_published":"2014-08-15T00:00:00Z","publication_identifier":{"issn":["1059-1524","1939-4586"]},"oa":1,"keyword":["Cell Biology","Molecular Biology"],"language":[{"iso":"eng"}],"publication":"Molecular Biology of the Cell","oa_version":"Published Version","month":"08"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","related_material":{"link":[{"url":"https://doi.org/10.1093/bioinformatics/btz397","relation":"erratum"}]},"type":"journal_article","date_published":"2014-08-01T00:00:00Z","publication_identifier":{"issn":["1367-4803","1460-2059"]},"keyword":["Statistics and Probability","Computational Theory and Mathematics","Biochemistry","Molecular Biology","Computational Mathematics","Computer Science Applications"],"language":[{"iso":"eng"}],"publication":"Bioinformatics","month":"08","oa_version":"None","extern":"1","volume":30,"year":"2014","citation":{"chicago":"Morin, Sébastien, Troels E Linnet, Mathilde Lescanne, Paul Schanda, Gary S Thompson, Martin Tollinger, Kaare Teilum, et al. “Relax: The Analysis of Biomolecular Kinetics and Thermodynamics Using NMR Relaxation Dispersion Data.” <i>Bioinformatics</i>. Oxford University Press, 2014. <a href=\"https://doi.org/10.1093/bioinformatics/btu166\">https://doi.org/10.1093/bioinformatics/btu166</a>.","ieee":"S. Morin <i>et al.</i>, “Relax: The analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data,” <i>Bioinformatics</i>, vol. 30, no. 15. Oxford University Press, pp. 2219–2220, 2014.","ama":"Morin S, Linnet TE, Lescanne M, et al. Relax: The analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data. <i>Bioinformatics</i>. 2014;30(15):2219-2220. doi:<a href=\"https://doi.org/10.1093/bioinformatics/btu166\">10.1093/bioinformatics/btu166</a>","apa":"Morin, S., Linnet, T. E., Lescanne, M., Schanda, P., Thompson, G. S., Tollinger, M., … d’Auvergne, E. J. (2014). Relax: The analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data. <i>Bioinformatics</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/bioinformatics/btu166\">https://doi.org/10.1093/bioinformatics/btu166</a>","ista":"Morin S, Linnet TE, Lescanne M, Schanda P, Thompson GS, Tollinger M, Teilum K, Gagné S, Marion D, Griesinger C, Blackledge M, d’Auvergne EJ. 2014. Relax: The analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data. Bioinformatics. 30(15), 2219–2220.","short":"S. Morin, T.E. Linnet, M. Lescanne, P. Schanda, G.S. Thompson, M. Tollinger, K. Teilum, S. Gagné, D. Marion, C. Griesinger, M. Blackledge, E.J. d’Auvergne, Bioinformatics 30 (2014) 2219–2220.","mla":"Morin, Sébastien, et al. “Relax: The Analysis of Biomolecular Kinetics and Thermodynamics Using NMR Relaxation Dispersion Data.” <i>Bioinformatics</i>, vol. 30, no. 15, Oxford University Press, 2014, pp. 2219–20, doi:<a href=\"https://doi.org/10.1093/bioinformatics/btu166\">10.1093/bioinformatics/btu166</a>."},"date_updated":"2021-01-12T08:19:25Z","abstract":[{"text":"Nuclear magnetic resonance (NMR) is a powerful tool for observing the motion of biomolecules at the atomic level. One technique, the analysis of relaxation dispersion phenomenon, is highly suited for studying the kinetics and thermodynamics of biological processes. Built on top of the relax computational environment for NMR dynamics is a new dispersion analysis designed to be comprehensive, accurate and easy-to-use. The software supports more models, both numeric and analytic, than current solutions. An automated protocol, available for scripting and driving the graphical user interface (GUI), is designed to simplify the analysis of dispersion data for NMR spectroscopists. Decreases in optimization time are granted by parallelization for running on computer clusters and by skipping an initial grid search by using parameters from one solution as the starting point for another —using analytic model results for the numeric models, taking advantage of model nesting, and using averaged non-clustered results for the clustered analysis.","lang":"eng"}],"day":"01","doi":"10.1093/bioinformatics/btu166","quality_controlled":"1","page":"2219-2220","article_type":"original","publisher":"Oxford University Press","issue":"15","author":[{"last_name":"Morin","first_name":"Sébastien","full_name":"Morin, Sébastien"},{"full_name":"Linnet, Troels E","first_name":"Troels E","last_name":"Linnet"},{"full_name":"Lescanne, Mathilde","first_name":"Mathilde","last_name":"Lescanne"},{"id":"7B541462-FAF6-11E9-A490-E8DFE5697425","orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul","first_name":"Paul","last_name":"Schanda"},{"first_name":"Gary S","last_name":"Thompson","full_name":"Thompson, Gary S"},{"first_name":"Martin","last_name":"Tollinger","full_name":"Tollinger, Martin"},{"first_name":"Kaare","last_name":"Teilum","full_name":"Teilum, Kaare"},{"last_name":"Gagné","first_name":"Stéphane","full_name":"Gagné, Stéphane"},{"last_name":"Marion","first_name":"Dominique","full_name":"Marion, Dominique"},{"full_name":"Griesinger, Christian","first_name":"Christian","last_name":"Griesinger"},{"first_name":"Martin","last_name":"Blackledge","full_name":"Blackledge, Martin"},{"full_name":"d’Auvergne, Edward J","last_name":"d’Auvergne","first_name":"Edward J"}],"_id":"8459","intvolume":"        30","title":"Relax: The analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data","date_created":"2020-09-18T10:08:07Z","article_processing_charge":"No","publication_status":"published"},{"main_file_link":[{"url":"https://doi.org/10.1038/ncomms4588","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2014-04-07T00:00:00Z","type":"journal_article","publication_identifier":{"eissn":["2041-1723"]},"oa":1,"language":[{"iso":"eng"}],"keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"publication":"Nature Communications","oa_version":"Published Version","month":"04","article_number":"3588","volume":5,"extern":"1","date_updated":"2023-08-08T07:28:10Z","year":"2014","citation":{"apa":"Kundu, P. K., Olsen, G. L., Kiss, V., &#38; Klajn, R. (2014). Nanoporous frameworks exhibiting multiple stimuli responsiveness. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/ncomms4588\">https://doi.org/10.1038/ncomms4588</a>","ama":"Kundu PK, Olsen GL, Kiss V, Klajn R. Nanoporous frameworks exhibiting multiple stimuli responsiveness. <i>Nature Communications</i>. 2014;5. doi:<a href=\"https://doi.org/10.1038/ncomms4588\">10.1038/ncomms4588</a>","ieee":"P. K. Kundu, G. L. Olsen, V. Kiss, and R. Klajn, “Nanoporous frameworks exhibiting multiple stimuli responsiveness,” <i>Nature Communications</i>, vol. 5. Springer Nature, 2014.","chicago":"Kundu, Pintu K., Gregory L. Olsen, Vladimir Kiss, and Rafal Klajn. “Nanoporous Frameworks Exhibiting Multiple Stimuli Responsiveness.” <i>Nature Communications</i>. Springer Nature, 2014. <a href=\"https://doi.org/10.1038/ncomms4588\">https://doi.org/10.1038/ncomms4588</a>.","mla":"Kundu, Pintu K., et al. “Nanoporous Frameworks Exhibiting Multiple Stimuli Responsiveness.” <i>Nature Communications</i>, vol. 5, 3588, Springer Nature, 2014, doi:<a href=\"https://doi.org/10.1038/ncomms4588\">10.1038/ncomms4588</a>.","short":"P.K. Kundu, G.L. Olsen, V. Kiss, R. Klajn, Nature Communications 5 (2014).","ista":"Kundu PK, Olsen GL, Kiss V, Klajn R. 2014. Nanoporous frameworks exhibiting multiple stimuli responsiveness. Nature Communications. 5, 3588."},"external_id":{"pmid":["24709950"]},"doi":"10.1038/ncomms4588","day":"07","abstract":[{"lang":"eng","text":"Nanoporous frameworks are polymeric materials built from rigid molecules, which give rise to their nanoporous structures with applications in gas sorption and storage, catalysis and others. Conceptually new applications could emerge, should these beneficial properties be manipulated by external stimuli in a reversible manner. One approach to render nanoporous frameworks responsive to external signals would be to immobilize molecular switches within their nanopores. Although the majority of molecular switches require conformational freedom to isomerize, and switching in the solid state is prohibited, the nanopores may provide enough room for the switches to efficiently isomerize. Here we describe two families of nanoporous materials incorporating the spiropyran molecular switch. These materials exhibit a variety of interesting properties, including reversible photochromism and acidochromism under solvent-free conditions, light-controlled capture and release of metal ions, as well reversible chromism induced by solvation/desolvation."}],"quality_controlled":"1","publisher":"Springer Nature","article_type":"original","_id":"13402","pmid":1,"scopus_import":"1","author":[{"first_name":"Pintu K.","last_name":"Kundu","full_name":"Kundu, Pintu K."},{"first_name":"Gregory L.","last_name":"Olsen","full_name":"Olsen, Gregory L."},{"full_name":"Kiss, Vladimir","last_name":"Kiss","first_name":"Vladimir"},{"id":"8e84690e-1e48-11ed-a02b-a1e6fb8bb53b","last_name":"Klajn","first_name":"Rafal","full_name":"Klajn, Rafal"}],"publication_status":"published","article_processing_charge":"No","date_created":"2023-08-01T09:46:27Z","title":"Nanoporous frameworks exhibiting multiple stimuli responsiveness","intvolume":"         5"},{"publication_status":"published","date_created":"2023-08-10T06:38:48Z","article_processing_charge":"No","title":"Two-pulse orientation dynamics and high-harmonic spectroscopy of strongly-oriented molecules","intvolume":"        47","_id":"14021","scopus_import":"1","author":[{"first_name":"P M","last_name":"Kraus","full_name":"Kraus, P M"},{"last_name":"Baykusheva","first_name":"Denitsa Rangelova","full_name":"Baykusheva, Denitsa Rangelova","id":"71b4d059-2a03-11ee-914d-dfa3beed6530"},{"first_name":"H J","last_name":"Wörner","full_name":"Wörner, H J"}],"issue":"12","publisher":"IOP Publishing","article_type":"original","quality_controlled":"1","doi":"10.1088/0953-4075/47/12/124030","arxiv":1,"day":"10","abstract":[{"text":"We present the detailed analysis of a new two-pulse orientation scheme that achieves macroscopic field-free orientation at the high particle densities required for attosecond and high-harmonic spectroscopies (Kraus et al 2013 arXiv:1311.3923). Carbon monoxide molecules are oriented by combining one-colour and delayed two-colour non-resonant femtosecond laser pulses. High-harmonic generation is used to probe the oriented wave-packet dynamics and reveals that a very high degree of orientation (Nup/Ntotal = 0.73–0.82) is achieved. We further extend this approach to orienting carbonyl sulphide molecules. We show that the present two-pulse scheme selectively enhances orientation created by the hyperpolarizability interaction whereas the ionization-depletion mechanism plays no role. We further control and optimize orientation through the delay between the one- and two-colour pump pulses. Finally, we demonstrate a complementary encoding of electronic-structure features, such as shape resonances, in the even- and odd-harmonic spectrum. The achieved progress makes two-pulse field-free orientation an attractive tool for a broad class of time-resolved measurements.","lang":"eng"}],"date_updated":"2023-08-22T09:04:30Z","citation":{"ista":"Kraus PM, Baykusheva DR, Wörner HJ. 2014. Two-pulse orientation dynamics and high-harmonic spectroscopy of strongly-oriented molecules. Journal of Physics B: Atomic, Molecular and Optical Physics. 47(12), 124030.","mla":"Kraus, P. M., et al. “Two-Pulse Orientation Dynamics and High-Harmonic Spectroscopy of Strongly-Oriented Molecules.” <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>, vol. 47, no. 12, 124030, IOP Publishing, 2014, doi:<a href=\"https://doi.org/10.1088/0953-4075/47/12/124030\">10.1088/0953-4075/47/12/124030</a>.","short":"P.M. Kraus, D.R. Baykusheva, H.J. Wörner, Journal of Physics B: Atomic, Molecular and Optical Physics 47 (2014).","chicago":"Kraus, P M, Denitsa Rangelova Baykusheva, and H J Wörner. “Two-Pulse Orientation Dynamics and High-Harmonic Spectroscopy of Strongly-Oriented Molecules.” <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>. IOP Publishing, 2014. <a href=\"https://doi.org/10.1088/0953-4075/47/12/124030\">https://doi.org/10.1088/0953-4075/47/12/124030</a>.","ieee":"P. M. Kraus, D. R. Baykusheva, and H. J. Wörner, “Two-pulse orientation dynamics and high-harmonic spectroscopy of strongly-oriented molecules,” <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>, vol. 47, no. 12. IOP Publishing, 2014.","apa":"Kraus, P. M., Baykusheva, D. R., &#38; Wörner, H. J. (2014). Two-pulse orientation dynamics and high-harmonic spectroscopy of strongly-oriented molecules. <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/0953-4075/47/12/124030\">https://doi.org/10.1088/0953-4075/47/12/124030</a>","ama":"Kraus PM, Baykusheva DR, Wörner HJ. Two-pulse orientation dynamics and high-harmonic spectroscopy of strongly-oriented molecules. <i>Journal of Physics B: Atomic, Molecular and Optical Physics</i>. 2014;47(12). doi:<a href=\"https://doi.org/10.1088/0953-4075/47/12/124030\">10.1088/0953-4075/47/12/124030</a>"},"year":"2014","external_id":{"arxiv":["1311.3923"]},"volume":47,"extern":"1","oa_version":"Preprint","month":"06","article_number":"124030","publication":"Journal of Physics B: Atomic, Molecular and Optical Physics","language":[{"iso":"eng"}],"keyword":["Condensed Matter Physics","Atomic and Molecular Physics","and Optics"],"publication_identifier":{"issn":["0953-4075"],"eissn":["1361-6455"]},"oa":1,"date_published":"2014-06-10T00:00:00Z","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1311.3923"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public"},{"day":"01","doi":"10.1038/nrm3496","abstract":[{"lang":"eng","text":"Protein turnover is an effective way of maintaining a functional proteome, as old and potentially damaged polypeptides are destroyed and replaced by newly synthesized copies. An increasing number of intracellular proteins, however, have been identified that evade this turnover process and instead are maintained over a cell's lifetime. This diverse group of long-lived proteins might be particularly prone to accumulation of damage and thus have a crucial role in the functional deterioration of key regulatory processes during ageing."}],"citation":{"ama":"Toyama BH, Hetzer M. Protein homeostasis: Live long, won’t prosper. <i>Nature Reviews Molecular Cell Biology</i>. 2013;14:55-61. doi:<a href=\"https://doi.org/10.1038/nrm3496\">10.1038/nrm3496</a>","apa":"Toyama, B. H., &#38; Hetzer, M. (2013). Protein homeostasis: Live long, won’t prosper. <i>Nature Reviews Molecular Cell Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/nrm3496\">https://doi.org/10.1038/nrm3496</a>","ieee":"B. H. Toyama and M. Hetzer, “Protein homeostasis: Live long, won’t prosper,” <i>Nature Reviews Molecular Cell Biology</i>, vol. 14. Springer Nature, pp. 55–61, 2013.","chicago":"Toyama, Brandon H., and Martin Hetzer. “Protein Homeostasis: Live Long, Won’t Prosper.” <i>Nature Reviews Molecular Cell Biology</i>. Springer Nature, 2013. <a href=\"https://doi.org/10.1038/nrm3496\">https://doi.org/10.1038/nrm3496</a>.","short":"B.H. Toyama, M. Hetzer, Nature Reviews Molecular Cell Biology 14 (2013) 55–61.","mla":"Toyama, Brandon H., and Martin Hetzer. “Protein Homeostasis: Live Long, Won’t Prosper.” <i>Nature Reviews Molecular Cell Biology</i>, vol. 14, Springer Nature, 2013, pp. 55–61, doi:<a href=\"https://doi.org/10.1038/nrm3496\">10.1038/nrm3496</a>.","ista":"Toyama BH, Hetzer M. 2013. Protein homeostasis: Live long, won’t prosper. Nature Reviews Molecular Cell Biology. 14, 55–61."},"year":"2013","date_updated":"2022-07-18T08:37:53Z","external_id":{"pmid":["23258296"]},"volume":14,"extern":"1","date_created":"2022-04-07T07:50:43Z","article_processing_charge":"No","publication_status":"published","intvolume":"        14","title":"Protein homeostasis: Live long, won't prosper","scopus_import":"1","pmid":1,"_id":"11084","author":[{"full_name":"Toyama, Brandon H.","first_name":"Brandon H.","last_name":"Toyama"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X"}],"publisher":"Springer Nature","article_type":"original","quality_controlled":"1","page":"55-61","publication_identifier":{"issn":["1471-0072","1471-0080"]},"type":"journal_article","date_published":"2013-01-01T00:00:00Z","status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","oa_version":"None","month":"01","publication":"Nature Reviews Molecular Cell Biology","keyword":["Cell Biology","Molecular Biology"],"language":[{"iso":"eng"}]},{"publication":"Cell","month":"07","oa_version":"Published Version","language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology"],"date_published":"2013-07-03T00:00:00Z","type":"journal_article","oa":1,"publication_identifier":{"issn":["0092-8674"]},"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public","main_file_link":[{"url":"https://doi.org/10.1016/j.cell.2013.06.007","open_access":"1"}],"author":[{"first_name":"Emily M.","last_name":"Hatch","full_name":"Hatch, Emily M."},{"full_name":"Fischer, Andrew H.","last_name":"Fischer","first_name":"Andrew H."},{"full_name":"Deerinck, Thomas J.","first_name":"Thomas J.","last_name":"Deerinck"},{"first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"issue":"1","_id":"11085","pmid":1,"scopus_import":"1","title":"Catastrophic nuclear envelope collapse in cancer cell micronuclei","intvolume":"       154","publication_status":"published","article_processing_charge":"No","date_created":"2022-04-07T07:50:51Z","page":"47-60","quality_controlled":"1","article_type":"original","publisher":"Elsevier","external_id":{"pmid":["23827674"]},"date_updated":"2022-07-18T08:45:47Z","year":"2013","citation":{"apa":"Hatch, E. M., Fischer, A. H., Deerinck, T. J., &#38; Hetzer, M. (2013). Catastrophic nuclear envelope collapse in cancer cell micronuclei. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2013.06.007\">https://doi.org/10.1016/j.cell.2013.06.007</a>","ama":"Hatch EM, Fischer AH, Deerinck TJ, Hetzer M. Catastrophic nuclear envelope collapse in cancer cell micronuclei. <i>Cell</i>. 2013;154(1):47-60. doi:<a href=\"https://doi.org/10.1016/j.cell.2013.06.007\">10.1016/j.cell.2013.06.007</a>","ieee":"E. M. Hatch, A. H. Fischer, T. J. Deerinck, and M. Hetzer, “Catastrophic nuclear envelope collapse in cancer cell micronuclei,” <i>Cell</i>, vol. 154, no. 1. Elsevier, pp. 47–60, 2013.","chicago":"Hatch, Emily M., Andrew H. Fischer, Thomas J. Deerinck, and Martin Hetzer. “Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei.” <i>Cell</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.cell.2013.06.007\">https://doi.org/10.1016/j.cell.2013.06.007</a>.","short":"E.M. Hatch, A.H. Fischer, T.J. Deerinck, M. Hetzer, Cell 154 (2013) 47–60.","mla":"Hatch, Emily M., et al. “Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei.” <i>Cell</i>, vol. 154, no. 1, Elsevier, 2013, pp. 47–60, doi:<a href=\"https://doi.org/10.1016/j.cell.2013.06.007\">10.1016/j.cell.2013.06.007</a>.","ista":"Hatch EM, Fischer AH, Deerinck TJ, Hetzer M. 2013. Catastrophic nuclear envelope collapse in cancer cell micronuclei. Cell. 154(1), 47–60."},"abstract":[{"lang":"eng","text":"During mitotic exit, missegregated chromosomes can recruit their own nuclear envelope (NE) to form micronuclei (MN). MN have reduced functioning compared to primary nuclei in the same cell, although the two compartments appear to be structurally comparable. Here we show that over 60% of MN undergo an irreversible loss of compartmentalization during interphase due to NE collapse. This disruption of the MN, which is induced by defects in nuclear lamina assembly, drastically reduces nuclear functions and can trigger massive DNA damage. MN disruption is associated with chromatin compaction and invasion of endoplasmic reticulum (ER) tubules into the chromatin. We identified disrupted MN in both major subtypes of human non-small-cell lung cancer, suggesting that disrupted MN could be a useful objective biomarker for genomic instability in solid tumors. Our study shows that NE collapse is a key event underlying MN dysfunction and establishes a link between aberrant NE organization and aneuploidy."}],"doi":"10.1016/j.cell.2013.06.007","day":"03","extern":"1","volume":154},{"article_type":"original","publisher":"Public Library of Science","quality_controlled":"1","title":"Dynamic association of NUP98 with the human genome","intvolume":"         9","publication_status":"published","date_created":"2022-04-07T07:50:59Z","article_processing_charge":"No","author":[{"first_name":"Yun","last_name":"Liang","full_name":"Liang, Yun"},{"full_name":"Franks, Tobias M.","last_name":"Franks","first_name":"Tobias M."},{"full_name":"Marchetto, Maria C.","first_name":"Maria C.","last_name":"Marchetto"},{"last_name":"Gage","first_name":"Fred H.","full_name":"Gage, Fred H."},{"first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"issue":"2","_id":"11086","pmid":1,"scopus_import":"1","extern":"1","volume":9,"abstract":[{"text":"Faithful execution of developmental gene expression programs occurs at multiple levels and involves many different components such as transcription factors, histone-modification enzymes, and mRNA processing proteins. Recent evidence suggests that nucleoporins, well known components that control nucleo-cytoplasmic trafficking, have wide-ranging functions in developmental gene regulation that potentially extend beyond their role in nuclear transport. Whether the unexpected role of nuclear pore proteins in transcription regulation, which initially has been described in fungi and flies, also applies to human cells is unknown. Here we show at a genome-wide level that the nuclear pore protein NUP98 associates with developmentally regulated genes active during human embryonic stem cell differentiation. Overexpression of a dominant negative fragment of NUP98 levels decreases expression levels of NUP98-bound genes. In addition, we identify two modes of developmental gene regulation by NUP98 that are differentiated by the spatial localization of NUP98 target genes. Genes in the initial stage of developmental induction can associate with NUP98 that is embedded in the nuclear pores at the nuclear periphery. Alternatively, genes that are highly induced can interact with NUP98 in the nuclear interior, away from the nuclear pores. This work demonstrates for the first time that NUP98 dynamically associates with the human genome during differentiation, revealing a role of a nuclear pore protein in regulating developmental gene expression programs.","lang":"eng"}],"doi":"10.1371/journal.pgen.1003308","day":"28","external_id":{"pmid":["23468646"]},"date_updated":"2022-07-18T08:45:58Z","year":"2013","citation":{"short":"Y. Liang, T.M. Franks, M.C. Marchetto, F.H. Gage, M. Hetzer, PLoS Genetics 9 (2013).","mla":"Liang, Yun, et al. “Dynamic Association of NUP98 with the Human Genome.” <i>PLoS Genetics</i>, vol. 9, no. 2, e1003308, Public Library of Science, 2013, doi:<a href=\"https://doi.org/10.1371/journal.pgen.1003308\">10.1371/journal.pgen.1003308</a>.","ista":"Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer M. 2013. Dynamic association of NUP98 with the human genome. PLoS Genetics. 9(2), e1003308.","apa":"Liang, Y., Franks, T. M., Marchetto, M. C., Gage, F. H., &#38; Hetzer, M. (2013). Dynamic association of NUP98 with the human genome. <i>PLoS Genetics</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pgen.1003308\">https://doi.org/10.1371/journal.pgen.1003308</a>","ama":"Liang Y, Franks TM, Marchetto MC, Gage FH, Hetzer M. Dynamic association of NUP98 with the human genome. <i>PLoS Genetics</i>. 2013;9(2). doi:<a href=\"https://doi.org/10.1371/journal.pgen.1003308\">10.1371/journal.pgen.1003308</a>","chicago":"Liang, Yun, Tobias M. Franks, Maria C. Marchetto, Fred H. Gage, and Martin Hetzer. “Dynamic Association of NUP98 with the Human Genome.” <i>PLoS Genetics</i>. Public Library of Science, 2013. <a href=\"https://doi.org/10.1371/journal.pgen.1003308\">https://doi.org/10.1371/journal.pgen.1003308</a>.","ieee":"Y. Liang, T. M. Franks, M. C. Marchetto, F. H. Gage, and M. Hetzer, “Dynamic association of NUP98 with the human genome,” <i>PLoS Genetics</i>, vol. 9, no. 2. Public Library of Science, 2013."},"language":[{"iso":"eng"}],"keyword":["Cancer Research","Genetics (clinical)","Genetics","Molecular Biology","Ecology","Evolution","Behavior and Systematics"],"month":"02","article_number":"e1003308","oa_version":"Published Version","publication":"PLoS Genetics","status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1371/journal.pgen.1003308"}],"oa":1,"publication_identifier":{"issn":["1553-7404"]},"date_published":"2013-02-28T00:00:00Z","type":"journal_article"},{"doi":"10.1016/j.cell.2013.07.037","day":"29","abstract":[{"text":"Intracellular proteins with long lifespans have recently been linked to age-dependent defects, ranging from decreased fertility to the functional decline of neurons. Why long-lived proteins exist in metabolically active cellular environments and how they are maintained over time remains poorly understood. Here, we provide a system-wide identification of proteins with exceptional lifespans in the rat brain. These proteins are inefficiently replenished despite being translated robustly throughout adulthood. Using nucleoporins as a paradigm for long-term protein persistence, we found that nuclear pore complexes (NPCs) are maintained over a cell’s life through slow but finite exchange of even its most stable subcomplexes. This maintenance is limited, however, as some nucleoporin levels decrease during aging, providing a rationale for the previously observed age-dependent deterioration of NPC function. Our identification of a long-lived proteome reveals cellular components that are at increased risk for damage accumulation, linking long-term protein persistence to the cellular aging process.","lang":"eng"}],"date_updated":"2022-07-18T08:50:47Z","year":"2013","citation":{"ista":"Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR, Hetzer M. 2013. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell. 154(5), 971–982.","mla":"Toyama, Brandon H., et al. “Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures.” <i>Cell</i>, vol. 154, no. 5, Elsevier, 2013, pp. 971–82, doi:<a href=\"https://doi.org/10.1016/j.cell.2013.07.037\">10.1016/j.cell.2013.07.037</a>.","short":"B.H. Toyama, J.N. Savas, S.K. Park, M.S. Harris, N.T. Ingolia, J.R. Yates, M. Hetzer, Cell 154 (2013) 971–982.","chicago":"Toyama, Brandon H., Jeffrey N. Savas, Sung Kyu Park, Michael S. Harris, Nicholas T. Ingolia, John R. Yates, and Martin Hetzer. “Identification of Long-Lived Proteins Reveals Exceptional Stability of Essential Cellular Structures.” <i>Cell</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.cell.2013.07.037\">https://doi.org/10.1016/j.cell.2013.07.037</a>.","ieee":"B. H. Toyama <i>et al.</i>, “Identification of long-lived proteins reveals exceptional stability of essential cellular structures,” <i>Cell</i>, vol. 154, no. 5. Elsevier, pp. 971–982, 2013.","ama":"Toyama BH, Savas JN, Park SK, et al. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. <i>Cell</i>. 2013;154(5):971-982. doi:<a href=\"https://doi.org/10.1016/j.cell.2013.07.037\">10.1016/j.cell.2013.07.037</a>","apa":"Toyama, B. H., Savas, J. N., Park, S. K., Harris, M. S., Ingolia, N. T., Yates, J. R., &#38; Hetzer, M. (2013). Identification of long-lived proteins reveals exceptional stability of essential cellular structures. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2013.07.037\">https://doi.org/10.1016/j.cell.2013.07.037</a>"},"external_id":{"pmid":["23993091"]},"volume":154,"extern":"1","publication_status":"published","date_created":"2022-04-07T07:51:08Z","article_processing_charge":"No","title":"Identification of long-lived proteins reveals exceptional stability of essential cellular structures","intvolume":"       154","pmid":1,"_id":"11087","scopus_import":"1","author":[{"full_name":"Toyama, Brandon H.","last_name":"Toyama","first_name":"Brandon H."},{"last_name":"Savas","first_name":"Jeffrey N.","full_name":"Savas, Jeffrey N."},{"full_name":"Park, Sung Kyu","first_name":"Sung Kyu","last_name":"Park"},{"last_name":"Harris","first_name":"Michael S.","full_name":"Harris, Michael S."},{"full_name":"Ingolia, Nicholas T.","first_name":"Nicholas T.","last_name":"Ingolia"},{"last_name":"Yates","first_name":"John R.","full_name":"Yates, John R."},{"last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"issue":"5","publisher":"Elsevier","article_type":"original","page":"971-982","quality_controlled":"1","publication_identifier":{"issn":["0092-8674"]},"oa":1,"date_published":"2013-08-29T00:00:00Z","type":"journal_article","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cell.2013.07.037"}],"status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","oa_version":"Published Version","month":"08","publication":"Cell","language":[{"iso":"eng"}],"keyword":["General Biochemistry","Genetics and Molecular Biology"]},{"status":"public","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","extern":"1","volume":425,"type":"journal_article","date_published":"2013-08-09T00:00:00Z","citation":{"chicago":"Rennella, E., T. Cutuil, Paul Schanda, I. Ayala, F. Gabel, V. Forge, A. Corazza, G. Esposito, and B. Brutscher. “Oligomeric States along the Folding Pathways of Β2-Microglobulin: Kinetics, Thermodynamics, and Structure.” <i>Journal of Molecular Biology</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.jmb.2013.04.028\">https://doi.org/10.1016/j.jmb.2013.04.028</a>.","ieee":"E. Rennella <i>et al.</i>, “Oligomeric states along the folding pathways of β2-microglobulin: Kinetics, thermodynamics, and structure,” <i>Journal of Molecular Biology</i>, vol. 425, no. 15. Elsevier, pp. 2722–2736, 2013.","apa":"Rennella, E., Cutuil, T., Schanda, P., Ayala, I., Gabel, F., Forge, V., … Brutscher, B. (2013). Oligomeric states along the folding pathways of β2-microglobulin: Kinetics, thermodynamics, and structure. <i>Journal of Molecular Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jmb.2013.04.028\">https://doi.org/10.1016/j.jmb.2013.04.028</a>","ama":"Rennella E, Cutuil T, Schanda P, et al. Oligomeric states along the folding pathways of β2-microglobulin: Kinetics, thermodynamics, and structure. <i>Journal of Molecular Biology</i>. 2013;425(15):2722-2736. doi:<a href=\"https://doi.org/10.1016/j.jmb.2013.04.028\">10.1016/j.jmb.2013.04.028</a>","ista":"Rennella E, Cutuil T, Schanda P, Ayala I, Gabel F, Forge V, Corazza A, Esposito G, Brutscher B. 2013. Oligomeric states along the folding pathways of β2-microglobulin: Kinetics, thermodynamics, and structure. Journal of Molecular Biology. 425(15), 2722–2736.","short":"E. Rennella, T. Cutuil, P. Schanda, I. Ayala, F. Gabel, V. Forge, A. Corazza, G. Esposito, B. Brutscher, Journal of Molecular Biology 425 (2013) 2722–2736.","mla":"Rennella, E., et al. “Oligomeric States along the Folding Pathways of Β2-Microglobulin: Kinetics, Thermodynamics, and Structure.” <i>Journal of Molecular Biology</i>, vol. 425, no. 15, Elsevier, 2013, pp. 2722–36, doi:<a href=\"https://doi.org/10.1016/j.jmb.2013.04.028\">10.1016/j.jmb.2013.04.028</a>."},"year":"2013","date_updated":"2022-08-25T14:56:24Z","abstract":[{"lang":"eng","text":"The transition of proteins from their soluble functional state to amyloid fibrils and aggregates is associated with the onset of several human diseases. Protein aggregation often requires some structural reshaping and the subsequent formation of intermolecular contacts. Therefore, the study of the conformation of excited protein states and their ability to form oligomers is of primary importance for understanding the molecular basis of amyloid fibril formation. Here, we investigated the oligomerization processes that occur along the folding of the amyloidogenic human protein β2-microglobulin. The combination of real-time two-dimensional NMR data with real-time small-angle X-ray scattering measurements allowed us to derive thermodynamic and kinetic information on protein oligomerization of different conformational states populated along the folding pathways. In particular, we could demonstrate that a long-lived folding intermediate (I-state) has a higher propensity to oligomerize compared to the native state. Our data agree well with a simple five-state kinetic model that involves only monomeric and dimeric species. The dimers have an elongated shape with the dimerization interface located at the apical side of β2-microglobulin close to Pro32, the residue that has a trans conformation in the I-state and a cis conformation in the native (N) state. Our experimental data suggest that partial unfolding in the apical half of the protein close to Pro32 leads to an excited state conformation with enhanced propensity for oligomerization. This excited state becomes more populated in the transient I-state due to the destabilization of the native conformation by the trans-Pro32 configuration."}],"day":"09","publication_identifier":{"issn":["0022-2836"]},"doi":"10.1016/j.jmb.2013.04.028","keyword":["Molecular Biology"],"language":[{"iso":"eng"}],"quality_controlled":"1","page":"2722-2736","article_type":"original","publisher":"Elsevier","issue":"15","author":[{"full_name":"Rennella, E.","first_name":"E.","last_name":"Rennella"},{"full_name":"Cutuil, T.","last_name":"Cutuil","first_name":"T."},{"orcid":"0000-0002-9350-7606","full_name":"Schanda, Paul","first_name":"Paul","last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425"},{"first_name":"I.","last_name":"Ayala","full_name":"Ayala, I."},{"full_name":"Gabel, F.","first_name":"F.","last_name":"Gabel"},{"first_name":"V.","last_name":"Forge","full_name":"Forge, V."},{"last_name":"Corazza","first_name":"A.","full_name":"Corazza, A."},{"first_name":"G.","last_name":"Esposito","full_name":"Esposito, G."},{"first_name":"B.","last_name":"Brutscher","full_name":"Brutscher, B."}],"publication":"Journal of Molecular Biology","_id":"8462","intvolume":"       425","month":"08","title":"Oligomeric states along the folding pathways of β2-microglobulin: Kinetics, thermodynamics, and structure","date_created":"2020-09-18T10:09:12Z","article_processing_charge":"No","oa_version":"None","publication_status":"published"},{"abstract":[{"text":"Nuclear export of mRNAs is thought to occur exclusively through nuclear pore complexes. In this issue of Cell, Speese et al. identify an alternate pathway for mRNA export in muscle cells where ribonucleoprotein complexes involved in forming neuromuscular junctions transit the nuclear envelope by fusing with and budding through the nuclear membrane.","lang":"eng"}],"day":"11","doi":"10.1016/j.cell.2012.04.018","external_id":{"pmid":["22579277"]},"year":"2012","citation":{"ista":"Hatch EM, Hetzer M. 2012. RNP export by nuclear envelope budding. Cell. 149(4), 733–735.","mla":"Hatch, Emily M., and Martin Hetzer. “RNP Export by Nuclear Envelope Budding.” <i>Cell</i>, vol. 149, no. 4, Elsevier, 2012, pp. 733–35, doi:<a href=\"https://doi.org/10.1016/j.cell.2012.04.018\">10.1016/j.cell.2012.04.018</a>.","short":"E.M. Hatch, M. Hetzer, Cell 149 (2012) 733–735.","ieee":"E. M. Hatch and M. Hetzer, “RNP export by nuclear envelope budding,” <i>Cell</i>, vol. 149, no. 4. Elsevier, pp. 733–735, 2012.","chicago":"Hatch, Emily M., and Martin Hetzer. “RNP Export by Nuclear Envelope Budding.” <i>Cell</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.cell.2012.04.018\">https://doi.org/10.1016/j.cell.2012.04.018</a>.","ama":"Hatch EM, Hetzer M. RNP export by nuclear envelope budding. <i>Cell</i>. 2012;149(4):733-735. doi:<a href=\"https://doi.org/10.1016/j.cell.2012.04.018\">10.1016/j.cell.2012.04.018</a>","apa":"Hatch, E. M., &#38; Hetzer, M. (2012). RNP export by nuclear envelope budding. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2012.04.018\">https://doi.org/10.1016/j.cell.2012.04.018</a>"},"date_updated":"2022-07-18T08:58:48Z","extern":"1","volume":149,"intvolume":"       149","title":"RNP export by nuclear envelope budding","date_created":"2022-04-07T07:51:45Z","article_processing_charge":"No","publication_status":"published","issue":"4","author":[{"full_name":"Hatch, Emily M.","first_name":"Emily M.","last_name":"Hatch"},{"full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"scopus_import":"1","pmid":1,"_id":"11090","article_type":"letter_note","publisher":"Elsevier","quality_controlled":"1","page":"733-735","oa":1,"publication_identifier":{"issn":["0092-8674"]},"type":"journal_article","date_published":"2012-05-11T00:00:00Z","status":"public","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","main_file_link":[{"url":"https://doi.org/10.1016/j.cell.2012.04.018","open_access":"1"}],"month":"05","oa_version":"Published Version","publication":"Cell","keyword":["General Biochemistry","Genetics and Molecular Biology"],"language":[{"iso":"eng"}]},{"scopus_import":"1","pmid":1,"_id":"11093","issue":"2","author":[{"last_name":"D'Angelo","first_name":"Maximiliano A.","full_name":"D'Angelo, Maximiliano A."},{"last_name":"Gomez-Cavazos","first_name":"J. Sebastian","full_name":"Gomez-Cavazos, J. Sebastian"},{"full_name":"Mei, Arianna","first_name":"Arianna","last_name":"Mei"},{"full_name":"Lackner, Daniel H.","first_name":"Daniel H.","last_name":"Lackner"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","last_name":"HETZER","first_name":"Martin W"}],"article_processing_charge":"No","date_created":"2022-04-07T07:52:10Z","publication_status":"published","intvolume":"        22","title":"A change in nuclear pore complex composition regulates cell differentiation","quality_controlled":"1","page":"446-458","publisher":"Elsevier","article_type":"original","citation":{"chicago":"D’Angelo, Maximiliano A., J. Sebastian Gomez-Cavazos, Arianna Mei, Daniel H. Lackner, and Martin Hetzer. “A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation.” <i>Developmental Cell</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">https://doi.org/10.1016/j.devcel.2011.11.021</a>.","ieee":"M. A. D’Angelo, J. S. Gomez-Cavazos, A. Mei, D. H. Lackner, and M. Hetzer, “A change in nuclear pore complex composition regulates cell differentiation,” <i>Developmental Cell</i>, vol. 22, no. 2. Elsevier, pp. 446–458, 2012.","apa":"D’Angelo, M. A., Gomez-Cavazos, J. S., Mei, A., Lackner, D. H., &#38; Hetzer, M. (2012). A change in nuclear pore complex composition regulates cell differentiation. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">https://doi.org/10.1016/j.devcel.2011.11.021</a>","ama":"D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. A change in nuclear pore complex composition regulates cell differentiation. <i>Developmental Cell</i>. 2012;22(2):446-458. doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">10.1016/j.devcel.2011.11.021</a>","ista":"D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. 2012. A change in nuclear pore complex composition regulates cell differentiation. Developmental Cell. 22(2), 446–458.","mla":"D’Angelo, Maximiliano A., et al. “A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation.” <i>Developmental Cell</i>, vol. 22, no. 2, Elsevier, 2012, pp. 446–58, doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">10.1016/j.devcel.2011.11.021</a>.","short":"M.A. D’Angelo, J.S. Gomez-Cavazos, A. Mei, D.H. Lackner, M. Hetzer, Developmental Cell 22 (2012) 446–458."},"year":"2012","date_updated":"2022-07-18T08:53:16Z","external_id":{"pmid":["22264802"]},"day":"19","doi":"10.1016/j.devcel.2011.11.021","abstract":[{"lang":"eng","text":"Nuclear pore complexes (NPCs) are built from ∼30 different proteins called nucleoporins or Nups. Previous studies have shown that several Nups exhibit cell-type-specific expression and that mutations in NPC components result in tissue-specific diseases. Here we show that a specific change in NPC composition is required for both myogenic and neuronal differentiation. The transmembrane nucleoporin Nup210 is absent in proliferating myoblasts and embryonic stem cells (ESCs) but becomes expressed and incorporated into NPCs during cell differentiation. Preventing Nup210 production by RNAi blocks myogenesis and the differentiation of ESCs into neuroprogenitors. We found that the addition of Nup210 to NPCs does not affect nuclear transport but is required for the induction of genes that are essential for cell differentiation. Our results identify a single change in NPC composition as an essential step in cell differentiation and establish a role for Nup210 in gene expression regulation and cell fate determination."}],"volume":22,"extern":"1","publication":"Developmental Cell","oa_version":"Published Version","month":"01","keyword":["Developmental Biology","Cell Biology","General Biochemistry","Genetics and Molecular Biology","Molecular Biology"],"language":[{"iso":"eng"}],"type":"journal_article","date_published":"2012-01-19T00:00:00Z","publication_identifier":{"issn":["1534-5807"]},"oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.devcel.2011.11.021"}],"user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","status":"public"}]