---
_id: '8492'
abstract:
- lang: eng
  text: We demonstrate for different protein samples that 2D 1H−15N correlation NMR
    spectra can be recorded in a few seconds of acquisition time using a new band-selective
    optimized flip-angle short-transient heteronuclear multiple quantum coherence
    experiment. This has enabled us to measure fast hydrogen−deuterium exchange rate
    constants along the backbone of a small globular protein fragment by real-time
    2D NMR.
article_processing_charge: No
article_type: original
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Bernhard
  full_name: Brutscher, Bernhard
  last_name: Brutscher
citation:
  ama: Schanda P, Brutscher B. Very fast two-dimensional NMR spectroscopy for real-time
    investigation of dynamic events in proteins on the time scale of seconds. <i>Journal
    of the American Chemical Society</i>. 2005;127(22):8014-8015. doi:<a href="https://doi.org/10.1021/ja051306e">10.1021/ja051306e</a>
  apa: Schanda, P., &#38; Brutscher, B. (2005). Very fast two-dimensional NMR spectroscopy
    for real-time investigation of dynamic events in proteins on the time scale of
    seconds. <i>Journal of the American Chemical Society</i>. American Chemical Society.
    <a href="https://doi.org/10.1021/ja051306e">https://doi.org/10.1021/ja051306e</a>
  chicago: Schanda, Paul, and Bernhard Brutscher. “Very Fast Two-Dimensional NMR Spectroscopy
    for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of
    Seconds.” <i>Journal of the American Chemical Society</i>. American Chemical Society,
    2005. <a href="https://doi.org/10.1021/ja051306e">https://doi.org/10.1021/ja051306e</a>.
  ieee: P. Schanda and B. Brutscher, “Very fast two-dimensional NMR spectroscopy for
    real-time investigation of dynamic events in proteins on the time scale of seconds,”
    <i>Journal of the American Chemical Society</i>, vol. 127, no. 22. American Chemical
    Society, pp. 8014–8015, 2005.
  ista: Schanda P, Brutscher B. 2005. Very fast two-dimensional NMR spectroscopy for
    real-time investigation of dynamic events in proteins on the time scale of seconds.
    Journal of the American Chemical Society. 127(22), 8014–8015.
  mla: Schanda, Paul, and Bernhard Brutscher. “Very Fast Two-Dimensional NMR Spectroscopy
    for Real-Time Investigation of Dynamic Events in Proteins on the Time Scale of
    Seconds.” <i>Journal of the American Chemical Society</i>, vol. 127, no. 22, American
    Chemical Society, 2005, pp. 8014–15, doi:<a href="https://doi.org/10.1021/ja051306e">10.1021/ja051306e</a>.
  short: P. Schanda, B. Brutscher, Journal of the American Chemical Society 127 (2005)
    8014–8015.
date_created: 2020-09-18T10:14:05Z
date_published: 2005-05-14T00:00:00Z
date_updated: 2021-01-12T08:19:39Z
day: '14'
doi: 10.1021/ja051306e
extern: '1'
intvolume: '       127'
issue: '22'
keyword:
- Colloid and Surface Chemistry
- Biochemistry
- General Chemistry
- Catalysis
language:
- iso: eng
month: '05'
oa_version: None
page: 8014-8015
publication: Journal of the American Chemical Society
publication_identifier:
  issn:
  - 0002-7863
  - 1520-5126
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
status: public
title: Very fast two-dimensional NMR spectroscopy for real-time investigation of dynamic
  events in proteins on the time scale of seconds
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 127
year: '2005'
...