---
_id: '4266'
abstract:
- lang: eng
  text: Hybridization may influence evolution in a variety of ways. If hybrids are
    less fit, the geographical range of ecologically divergent populations may be
    limited, and prezygotic reproductive isolation may be reinforced. If some hybrid
    genotypes are fitter than one or both parents, at least in some environments,
    then hybridization could make a positive contribution. Single alleles that are
    at an advantage in the alternative environment and genetic background will introgress
    readily, although such introgression may be hard to detect. 'Hybrid speciation',
    in which fit combinations of alleles are established, is more problematic; its
    likelihood depends on how divergent populations meet, and on the structure of
    epistasis. These issues are illustrated using Fisher's model of stabilizing selection
    on multiple traits, under which reproductive isolation evolves as a side-effect
    of adaptation in allopatry. This confirms a priori arguments that while recombinant
    hybrids are less fit on average, some gene combinations may be fitter than the
    parents, even in the parental environment. Fisher's model does predict heterosis
    in diploid F1s, asymmetric incompatibility in reciprocal backcrosses, and (when
    dominance is included) Haldane's Rule. However, heterosis arises only when traits
    are additive, whereas the latter two patterns require dominance. Moreover, because
    adaptation is via substitutions of small effect, Fisher's model does not generate
    the strong effects of single chromosome regions often observed in species crosses.
acknowledgement: This work was supported by the Darwin Trust of Edinburgh and by  grant  GR3/11635  from  the  Natural  Environment  Research
  Council. I would like to thank Loren Rieseberg, Allen Orr, Michael Turelli, and
  an anonymous referee for their helpful comments
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
citation:
  ama: Barton NH. The role of hybridization in evolution. <i>Molecular Ecology</i>.
    2001;10(3):551-568. doi:<a href="https://doi.org/10.1046/j.1365-294X.2001.01216.x">10.1046/j.1365-294X.2001.01216.x</a>
  apa: Barton, N. H. (2001). The role of hybridization in evolution. <i>Molecular
    Ecology</i>. Wiley-Blackwell. <a href="https://doi.org/10.1046/j.1365-294X.2001.01216.x">https://doi.org/10.1046/j.1365-294X.2001.01216.x</a>
  chicago: Barton, Nicholas H. “The Role of Hybridization in Evolution.” <i>Molecular
    Ecology</i>. Wiley-Blackwell, 2001. <a href="https://doi.org/10.1046/j.1365-294X.2001.01216.x">https://doi.org/10.1046/j.1365-294X.2001.01216.x</a>.
  ieee: N. H. Barton, “The role of hybridization in evolution,” <i>Molecular Ecology</i>,
    vol. 10, no. 3. Wiley-Blackwell, pp. 551–568, 2001.
  ista: Barton NH. 2001. The role of hybridization in evolution. Molecular Ecology.
    10(3), 551–568.
  mla: Barton, Nicholas H. “The Role of Hybridization in Evolution.” <i>Molecular
    Ecology</i>, vol. 10, no. 3, Wiley-Blackwell, 2001, pp. 551–68, doi:<a href="https://doi.org/10.1046/j.1365-294X.2001.01216.x">10.1046/j.1365-294X.2001.01216.x</a>.
  short: N.H. Barton, Molecular Ecology 10 (2001) 551–568.
date_created: 2018-12-11T12:07:56Z
date_published: 2001-03-01T00:00:00Z
date_updated: 2023-05-10T11:45:07Z
day: '01'
doi: 10.1046/j.1365-294X.2001.01216.x
extern: '1'
external_id:
  pmid:
  - '11298968'
intvolume: '        10'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 551 - 568
pmid: 1
publication: Molecular Ecology
publication_identifier:
  issn:
  - 962-1083
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1824'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The role of hybridization in evolution
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '2001'
...