---
_id: '11053'
abstract:
- lang: eng
text: Understanding basic mechanisms of aging holds great promise for developing
interventions that prevent or delay many age-related declines and diseases simultaneously
to increase human healthspan. However, a major confounding factor in aging research
is the heterogeneity of the aging process itself. At the organismal level, it
is clear that chronological age does not always predict biological age or susceptibility
to frailty or pathology. While genetics and environment are major factors driving
variable rates of aging, additional complexity arises because different organs,
tissues, and cell types are intrinsically heterogeneous and exhibit different
aging trajectories normally or in response to the stresses of the aging process
(e.g., damage accumulation). Tackling the heterogeneity of aging requires new
and specialized tools (e.g., single-cell analyses, mass spectrometry-based approaches,
and advanced imaging) to identify novel signatures of aging across scales. Cutting-edge
computational approaches are then needed to integrate these disparate datasets
and elucidate network interactions between known aging hallmarks. There is also
a need for improved, human cell-based models of aging to ensure that basic research
findings are relevant to human aging and healthspan interventions. The San Diego
Nathan Shock Center (SD-NSC) provides access to cutting-edge scientific resources
to facilitate the study of the heterogeneity of aging in general and to promote
the use of novel human cell models of aging. The center also has a robust Research
Development Core that funds pilot projects on the heterogeneity of aging and organizes
innovative training activities, including workshops and a personalized mentoring
program, to help investigators new to the aging field succeed. Finally, the SD-NSC
participates in outreach activities to educate the general community about the
importance of aging research and promote the need for basic biology of aging research
in particular.
article_processing_charge: No
article_type: original
author:
- first_name: Gerald S.
full_name: Shadel, Gerald S.
last_name: Shadel
- first_name: Peter D.
full_name: Adams, Peter D.
last_name: Adams
- first_name: W. Travis
full_name: Berggren, W. Travis
last_name: Berggren
- first_name: Jolene K.
full_name: Diedrich, Jolene K.
last_name: Diedrich
- first_name: Kenneth E.
full_name: Diffenderfer, Kenneth E.
last_name: Diffenderfer
- first_name: Fred H.
full_name: Gage, Fred H.
last_name: Gage
- first_name: Nasun
full_name: Hah, Nasun
last_name: Hah
- first_name: Malene
full_name: Hansen, Malene
last_name: Hansen
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Anthony J. A.
full_name: Molina, Anthony J. A.
last_name: Molina
- first_name: Uri
full_name: Manor, Uri
last_name: Manor
- first_name: Kurt
full_name: Marek, Kurt
last_name: Marek
- first_name: David D.
full_name: O’Keefe, David D.
last_name: O’Keefe
- first_name: Antonio F. M.
full_name: Pinto, Antonio F. M.
last_name: Pinto
- first_name: Alessandra
full_name: Sacco, Alessandra
last_name: Sacco
- first_name: Tatyana O.
full_name: Sharpee, Tatyana O.
last_name: Sharpee
- first_name: Maxim N.
full_name: Shokriev, Maxim N.
last_name: Shokriev
- first_name: Stefania
full_name: Zambetti, Stefania
last_name: Zambetti
citation:
ama: 'Shadel GS, Adams PD, Berggren WT, et al. The San Diego Nathan Shock Center:
Tackling the heterogeneity of aging. GeroScience. 2021;43(5):2139-2148.
doi:10.1007/s11357-021-00426-x'
apa: 'Shadel, G. S., Adams, P. D., Berggren, W. T., Diedrich, J. K., Diffenderfer,
K. E., Gage, F. H., … Zambetti, S. (2021). The San Diego Nathan Shock Center:
Tackling the heterogeneity of aging. GeroScience. Springer Nature. https://doi.org/10.1007/s11357-021-00426-x'
chicago: 'Shadel, Gerald S., Peter D. Adams, W. Travis Berggren, Jolene K. Diedrich,
Kenneth E. Diffenderfer, Fred H. Gage, Nasun Hah, et al. “The San Diego Nathan
Shock Center: Tackling the Heterogeneity of Aging.” GeroScience. Springer
Nature, 2021. https://doi.org/10.1007/s11357-021-00426-x.'
ieee: 'G. S. Shadel et al., “The San Diego Nathan Shock Center: Tackling
the heterogeneity of aging,” GeroScience, vol. 43, no. 5. Springer Nature,
pp. 2139–2148, 2021.'
ista: 'Shadel GS, Adams PD, Berggren WT, Diedrich JK, Diffenderfer KE, Gage FH,
Hah N, Hansen M, Hetzer M, Molina AJA, Manor U, Marek K, O’Keefe DD, Pinto AFM,
Sacco A, Sharpee TO, Shokriev MN, Zambetti S. 2021. The San Diego Nathan Shock
Center: Tackling the heterogeneity of aging. GeroScience. 43(5), 2139–2148.'
mla: 'Shadel, Gerald S., et al. “The San Diego Nathan Shock Center: Tackling the
Heterogeneity of Aging.” GeroScience, vol. 43, no. 5, Springer Nature,
2021, pp. 2139–48, doi:10.1007/s11357-021-00426-x.'
short: G.S. Shadel, P.D. Adams, W.T. Berggren, J.K. Diedrich, K.E. Diffenderfer,
F.H. Gage, N. Hah, M. Hansen, M. Hetzer, A.J.A. Molina, U. Manor, K. Marek, D.D.
O’Keefe, A.F.M. Pinto, A. Sacco, T.O. Sharpee, M.N. Shokriev, S. Zambetti, GeroScience
43 (2021) 2139–2148.
date_created: 2022-04-07T07:43:25Z
date_published: 2021-10-01T00:00:00Z
date_updated: 2022-07-18T08:27:24Z
day: '01'
doi: 10.1007/s11357-021-00426-x
extern: '1'
external_id:
pmid:
- '34370163'
intvolume: ' 43'
issue: '5'
keyword:
- Geriatrics and Gerontology
- Aging
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599742/
month: '10'
oa: 1
oa_version: Published Version
page: 2139-2148
pmid: 1
publication: GeroScience
publication_identifier:
issn:
- 2509-2715
- 2509-2723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The San Diego Nathan Shock Center: Tackling the heterogeneity of aging'
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 43
year: '2021'
...