---
_id: '7715'
abstract:
- lang: eng
text: Preference for mates with similar phenotypes; that is, assortative mating,
is widely observed in humans1,2,3,4,5 and has evolutionary consequences6,7,8.
Under Fisher's classical theory6, assortative mating is predicted to induce a
signature in the genome at trait-associated loci that can be detected and quantified.
Here, we develop and apply a method to quantify assortative mating on a specific
trait by estimating the correlation (θ) between genetic predictors of the trait
from single nucleotide polymorphisms on odd- versus even-numbered chromosomes.
We show by theory and simulation that the effect of assortative mating can be
quantified in the presence of population stratification. We applied this approach
to 32 complex traits and diseases using single nucleotide polymorphism data from
~400,000 unrelated individuals of European ancestry. We found significant evidence
of assortative mating for height (θ = 3.2%) and educational attainment (θ = 2.7%),
both of which were consistent with theoretical predictions. Overall, our results
imply that assortative mating involves multiple traits and affects the genomic
architecture of loci that are associated with these traits, and that the consequence
of mate choice can be detected from a random sample of genomes.
article_processing_charge: No
article_type: original
author:
- first_name: Loic
full_name: Yengo, Loic
last_name: Yengo
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Matthew C.
full_name: Keller, Matthew C.
last_name: Keller
- first_name: Kathryn E.
full_name: Kemper, Kathryn E.
last_name: Kemper
- first_name: Yuanhao
full_name: Yang, Yuanhao
last_name: Yang
- first_name: Maciej
full_name: Trzaskowski, Maciej
last_name: Trzaskowski
- first_name: Jacob
full_name: Gratten, Jacob
last_name: Gratten
- first_name: Patrick
full_name: Turley, Patrick
last_name: Turley
- first_name: David
full_name: Cesarini, David
last_name: Cesarini
- first_name: Daniel J.
full_name: Benjamin, Daniel J.
last_name: Benjamin
- first_name: Naomi R.
full_name: Wray, Naomi R.
last_name: Wray
- first_name: Michael E.
full_name: Goddard, Michael E.
last_name: Goddard
- first_name: Jian
full_name: Yang, Jian
last_name: Yang
- first_name: Peter M.
full_name: Visscher, Peter M.
last_name: Visscher
citation:
ama: Yengo L, Robinson MR, Keller MC, et al. Imprint of assortative mating on the
human genome. Nature Human Behaviour. 2018;2(12):948-954. doi:10.1038/s41562-018-0476-3
apa: Yengo, L., Robinson, M. R., Keller, M. C., Kemper, K. E., Yang, Y., Trzaskowski,
M., … Visscher, P. M. (2018). Imprint of assortative mating on the human genome.
Nature Human Behaviour. Springer Nature. https://doi.org/10.1038/s41562-018-0476-3
chicago: Yengo, Loic, Matthew Richard Robinson, Matthew C. Keller, Kathryn E. Kemper,
Yuanhao Yang, Maciej Trzaskowski, Jacob Gratten, et al. “Imprint of Assortative
Mating on the Human Genome.” Nature Human Behaviour. Springer Nature, 2018.
https://doi.org/10.1038/s41562-018-0476-3.
ieee: L. Yengo et al., “Imprint of assortative mating on the human genome,”
Nature Human Behaviour, vol. 2, no. 12. Springer Nature, pp. 948–954, 2018.
ista: Yengo L, Robinson MR, Keller MC, Kemper KE, Yang Y, Trzaskowski M, Gratten
J, Turley P, Cesarini D, Benjamin DJ, Wray NR, Goddard ME, Yang J, Visscher PM.
2018. Imprint of assortative mating on the human genome. Nature Human Behaviour.
2(12), 948–954.
mla: Yengo, Loic, et al. “Imprint of Assortative Mating on the Human Genome.” Nature
Human Behaviour, vol. 2, no. 12, Springer Nature, 2018, pp. 948–54, doi:10.1038/s41562-018-0476-3.
short: L. Yengo, M.R. Robinson, M.C. Keller, K.E. Kemper, Y. Yang, M. Trzaskowski,
J. Gratten, P. Turley, D. Cesarini, D.J. Benjamin, N.R. Wray, M.E. Goddard, J.
Yang, P.M. Visscher, Nature Human Behaviour 2 (2018) 948–954.
date_created: 2020-04-30T10:42:12Z
date_published: 2018-11-26T00:00:00Z
date_updated: 2021-01-12T08:15:03Z
day: '26'
doi: 10.1038/s41562-018-0476-3
extern: '1'
intvolume: ' 2'
issue: '12'
language:
- iso: eng
month: '11'
oa_version: None
page: 948-954
publication: Nature Human Behaviour
publication_identifier:
issn:
- 2397-3374
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Imprint of assortative mating on the human genome
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 2
year: '2018'
...
---
_id: '7728'
abstract:
- lang: eng
text: 'Meta-analyses of genome-wide association studies, which dominate genetic
discovery, are based on data from diverse historical time periods and populations.
Genetic scores derived from genome-wide association studies explain only a fraction
of the heritability estimates obtained from whole-genome studies on single populations,
known as the ‘hidden heritability’ puzzle. Using seven sampling populations (n = 35,062),
we test whether hidden heritability is attributed to heterogeneity across sampling
populations and time, showing that estimates are substantially smaller across
populations compared with within populations. We show that the hidden heritability
varies substantially: from zero for height to 20% for body mass index, 37% for
education, 40% for age at first birth and up to 75% for number of children. Simulations
demonstrate that our results are more likely to reflect heterogeneity in phenotypic
measurement or gene–environment interactions than genetic heterogeneity. These
findings have substantial implications for genetic discovery, suggesting that
large homogenous datasets are required for behavioural phenotypes and that gene–environment
interaction may be a central challenge for genetic discovery.'
article_processing_charge: No
article_type: original
author:
- first_name: Felix C.
full_name: Tropf, Felix C.
last_name: Tropf
- first_name: S. Hong
full_name: Lee, S. Hong
last_name: Lee
- first_name: Renske M.
full_name: Verweij, Renske M.
last_name: Verweij
- first_name: Gert
full_name: Stulp, Gert
last_name: Stulp
- first_name: Peter J.
full_name: van der Most, Peter J.
last_name: van der Most
- first_name: Ronald
full_name: de Vlaming, Ronald
last_name: de Vlaming
- first_name: Andrew
full_name: Bakshi, Andrew
last_name: Bakshi
- first_name: Daniel A.
full_name: Briley, Daniel A.
last_name: Briley
- first_name: Charles
full_name: Rahal, Charles
last_name: Rahal
- first_name: Robert
full_name: Hellpap, Robert
last_name: Hellpap
- first_name: Anastasia N.
full_name: Iliadou, Anastasia N.
last_name: Iliadou
- first_name: Tõnu
full_name: Esko, Tõnu
last_name: Esko
- first_name: Andres
full_name: Metspalu, Andres
last_name: Metspalu
- first_name: Sarah E.
full_name: Medland, Sarah E.
last_name: Medland
- first_name: Nicholas G.
full_name: Martin, Nicholas G.
last_name: Martin
- first_name: Nicola
full_name: Barban, Nicola
last_name: Barban
- first_name: Harold
full_name: Snieder, Harold
last_name: Snieder
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Melinda C.
full_name: Mills, Melinda C.
last_name: Mills
citation:
ama: Tropf FC, Lee SH, Verweij RM, et al. Hidden heritability due to heterogeneity
across seven populations. Nature Human Behaviour. 2017;1(10):757-765. doi:10.1038/s41562-017-0195-1
apa: Tropf, F. C., Lee, S. H., Verweij, R. M., Stulp, G., van der Most, P. J., de
Vlaming, R., … Mills, M. C. (2017). Hidden heritability due to heterogeneity across
seven populations. Nature Human Behaviour. Springer Nature. https://doi.org/10.1038/s41562-017-0195-1
chicago: Tropf, Felix C., S. Hong Lee, Renske M. Verweij, Gert Stulp, Peter J. van
der Most, Ronald de Vlaming, Andrew Bakshi, et al. “Hidden Heritability Due to
Heterogeneity across Seven Populations.” Nature Human Behaviour. Springer
Nature, 2017. https://doi.org/10.1038/s41562-017-0195-1.
ieee: F. C. Tropf et al., “Hidden heritability due to heterogeneity across
seven populations,” Nature Human Behaviour, vol. 1, no. 10. Springer Nature,
pp. 757–765, 2017.
ista: Tropf FC, Lee SH, Verweij RM, Stulp G, van der Most PJ, de Vlaming R, Bakshi
A, Briley DA, Rahal C, Hellpap R, Iliadou AN, Esko T, Metspalu A, Medland SE,
Martin NG, Barban N, Snieder H, Robinson MR, Mills MC. 2017. Hidden heritability
due to heterogeneity across seven populations. Nature Human Behaviour. 1(10),
757–765.
mla: Tropf, Felix C., et al. “Hidden Heritability Due to Heterogeneity across Seven
Populations.” Nature Human Behaviour, vol. 1, no. 10, Springer Nature,
2017, pp. 757–65, doi:10.1038/s41562-017-0195-1.
short: F.C. Tropf, S.H. Lee, R.M. Verweij, G. Stulp, P.J. van der Most, R. de Vlaming,
A. Bakshi, D.A. Briley, C. Rahal, R. Hellpap, A.N. Iliadou, T. Esko, A. Metspalu,
S.E. Medland, N.G. Martin, N. Barban, H. Snieder, M.R. Robinson, M.C. Mills, Nature
Human Behaviour 1 (2017) 757–765.
date_created: 2020-04-30T10:47:02Z
date_published: 2017-09-11T00:00:00Z
date_updated: 2021-01-12T08:15:08Z
day: '11'
doi: 10.1038/s41562-017-0195-1
extern: '1'
intvolume: ' 1'
issue: '10'
language:
- iso: eng
month: '09'
oa_version: None
page: 757-765
publication: Nature Human Behaviour
publication_identifier:
issn:
- 2397-3374
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Hidden heritability due to heterogeneity across seven populations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1
year: '2017'
...