---
_id: '10369'
abstract:
- lang: eng
  text: Biological membranes have a central role in mediating the organization of
    membrane-curving proteins, a dynamic process that has proven to be challenging
    to probe experimentally. Using atomic force microscopy, we capture the hierarchically
    organized assemblies of Bin/amphiphysin/Rvs (BAR) proteins on supported lipid
    membranes. Their structure reveals distinct long linear aggregates of proteins,
    regularly spaced by up to 300 nm. Employing accurate free-energy calculations
    from large-scale coarse-grained computer simulations, we found that the membrane
    mediates the interaction among protein filaments as a combination of short- and
    long-ranged interactions. The long-ranged component acts at strikingly long distances,
    giving rise to a variety of micron-sized ordered patterns. This mechanism may
    contribute to the long-ranged spatiotemporal control of membrane remodeling by
    proteins in the cell.
acknowledgement: M.S. and G.A.V. acknowledge their research reported in this publication
  as being supported by the National Institute of General Medical Sciences of the
  National Institutes of Health under Award Number R01-GM063796. Computational resources
  were provided to M.S. and G.A.V. by the National Science Foundation through XSEDE
  (Grant TG-MCA94P017, supercomputers Stampede and Gordon), and also by the Blue Waters
  computing project at the National Center for Supercomputing Applications (University
  of Illinois at Urbana–Champaign, NSF Awards OCI-0725070 and ACI-1238993). A.Š. acknowledges
  support from the Human Frontier Science Program and Royal Society. J.M.H. and K.Y.C.L.
  acknowledge the support from the National Science Foundation (Grant MCB-1413613)
  and the NSF-supported MRSEC program at the University of Chicago (Grant DMR-1420709).
  We are grateful to Carsten Mim and Vinzenz Unger of Northwestern University for
  generously providing us with the protein. We thank all the members of the Voth group
  for fruitful discussions, especially John M. A. Grime.
article_processing_charge: No
article_type: original
author:
- first_name: Mijo
  full_name: Simunovic, Mijo
  last_name: Simunovic
- first_name: Anđela
  full_name: Šarić, Anđela
  id: bf63d406-f056-11eb-b41d-f263a6566d8b
  last_name: Šarić
  orcid: 0000-0002-7854-2139
- first_name: J. Michael
  full_name: Henderson, J. Michael
  last_name: Henderson
- first_name: Ka Yee C.
  full_name: Lee, Ka Yee C.
  last_name: Lee
- first_name: Gregory A.
  full_name: Voth, Gregory A.
  last_name: Voth
citation:
  ama: Simunovic M, Šarić A, Henderson JM, Lee KYC, Voth GA. Long-range organization
    of membrane-curving proteins. <i>ACS Central Science</i>. 2017;3(12):1246-1253.
    doi:<a href="https://doi.org/10.1021/acscentsci.7b00392">10.1021/acscentsci.7b00392</a>
  apa: Simunovic, M., Šarić, A., Henderson, J. M., Lee, K. Y. C., &#38; Voth, G. A.
    (2017). Long-range organization of membrane-curving proteins. <i>ACS Central Science</i>.
    American Chemical Society. <a href="https://doi.org/10.1021/acscentsci.7b00392">https://doi.org/10.1021/acscentsci.7b00392</a>
  chicago: Simunovic, Mijo, Anđela Šarić, J. Michael Henderson, Ka Yee C. Lee, and
    Gregory A. Voth. “Long-Range Organization of Membrane-Curving Proteins.” <i>ACS
    Central Science</i>. American Chemical Society, 2017. <a href="https://doi.org/10.1021/acscentsci.7b00392">https://doi.org/10.1021/acscentsci.7b00392</a>.
  ieee: M. Simunovic, A. Šarić, J. M. Henderson, K. Y. C. Lee, and G. A. Voth, “Long-range
    organization of membrane-curving proteins,” <i>ACS Central Science</i>, vol. 3,
    no. 12. American Chemical Society, pp. 1246–1253, 2017.
  ista: Simunovic M, Šarić A, Henderson JM, Lee KYC, Voth GA. 2017. Long-range organization
    of membrane-curving proteins. ACS Central Science. 3(12), 1246–1253.
  mla: Simunovic, Mijo, et al. “Long-Range Organization of Membrane-Curving Proteins.”
    <i>ACS Central Science</i>, vol. 3, no. 12, American Chemical Society, 2017, pp.
    1246–53, doi:<a href="https://doi.org/10.1021/acscentsci.7b00392">10.1021/acscentsci.7b00392</a>.
  short: M. Simunovic, A. Šarić, J.M. Henderson, K.Y.C. Lee, G.A. Voth, ACS Central
    Science 3 (2017) 1246–1253.
date_created: 2021-11-29T08:49:50Z
date_published: 2017-11-21T00:00:00Z
date_updated: 2021-11-29T09:28:06Z
day: '21'
ddc:
- '540'
doi: 10.1021/acscentsci.7b00392
extern: '1'
external_id:
  pmid:
  - '29296664'
file:
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has_accepted_license: '1'
intvolume: '         3'
issue: '12'
keyword:
- general chemical engineering
- general chemistry
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://pubs.acs.org/doi/10.1021/acscentsci.7b00392
month: '11'
oa: 1
oa_version: Published Version
page: 1246-1253
pmid: 1
publication: ACS Central Science
publication_identifier:
  eissn:
  - 2374-7951
  issn:
  - 2374-7943
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Long-range organization of membrane-curving proteins
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
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type: journal_article
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volume: 3
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...