---
_id: '7734'
abstract:
- lang: eng
text: "Importance: Considerable partner resemblances have been found for a wide
range of psychiatric disorders, meaning that partners of affected individuals
have an increased risk of being affected compared with partners of unaffected
individuals. If this resemblance is reflected in genetic similarity between partners,
genetic risk is anticipated to accumulate in offspring, but these potential consequences
have not been quantified and have been left implicit.\r\n\r\nObservations: The
anticipated consequences of partner resemblance on prevalence and heritability
of psychiatric traits in the offspring generation were modeled for disorders with
varying heritabilities, population prevalence (lifetime risk), and magnitudes
of partner resemblance. These models facilitate interpretation for a wide range
of psychiatric disorders, such as autism, schizophrenia, and depression. The genetic
consequences of partner resemblance are most pronounced when attributable to phenotypic
assortment (driven by the psychiatric trait). Phenotypic assortment results in
increased genetic variance in the offspring generation, which may result in increased
heritability and population prevalence. These consequences add generation after
generation to a limit, but assortative mating is unlikely to balance the impact
of reduced fecundity of patients with psychiatric disorders in the long term.
This modeling suggests that the heritabilities of psychiatric disorders are unlikely
to increase by more than 5% from 1 generation of assortative mating (maximally
13% across multiple generations). The population prevalence will increase most
for less common disorders with high heritability; for example, the prevalence
of autism might increase by 1.5-fold after 1 generation of assortative mating
(≥2.4-fold in the long term) depending on several assumptions.\r\n\r\nConclusions
and Relevance: The considerable partner resemblances found for psychiatric disorders
deserve more detailed interpretation than has been provided thus far. Although
the limitations of modeling are emphasized, the anticipated consequences are at
most modest for the heritability but may be considerable for the population prevalence
of rare disorders with a high heritability."
article_processing_charge: No
article_type: original
author:
- first_name: Wouter J.
full_name: Peyrot, Wouter J.
last_name: Peyrot
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
- first_name: Brenda W. J. H.
full_name: Penninx, Brenda W. J. H.
last_name: Penninx
- first_name: Naomi R.
full_name: Wray, Naomi R.
last_name: Wray
citation:
ama: Peyrot WJ, Robinson MR, Penninx BWJH, Wray NR. Exploring boundaries for the
genetic consequences of assortative mating for psychiatric traits. JAMA Psychiatry.
2016;73(11):1189-1195. doi:10.1001/jamapsychiatry.2016.2566
apa: Peyrot, W. J., Robinson, M. R., Penninx, B. W. J. H., & Wray, N. R. (2016).
Exploring boundaries for the genetic consequences of assortative mating for psychiatric
traits. JAMA Psychiatry. American Medical Association. https://doi.org/10.1001/jamapsychiatry.2016.2566
chicago: Peyrot, Wouter J., Matthew Richard Robinson, Brenda W. J. H. Penninx, and
Naomi R. Wray. “Exploring Boundaries for the Genetic Consequences of Assortative
Mating for Psychiatric Traits.” JAMA Psychiatry. American Medical Association,
2016. https://doi.org/10.1001/jamapsychiatry.2016.2566.
ieee: W. J. Peyrot, M. R. Robinson, B. W. J. H. Penninx, and N. R. Wray, “Exploring
boundaries for the genetic consequences of assortative mating for psychiatric
traits,” JAMA Psychiatry, vol. 73, no. 11. American Medical Association,
pp. 1189–1195, 2016.
ista: Peyrot WJ, Robinson MR, Penninx BWJH, Wray NR. 2016. Exploring boundaries
for the genetic consequences of assortative mating for psychiatric traits. JAMA
Psychiatry. 73(11), 1189–1195.
mla: Peyrot, Wouter J., et al. “Exploring Boundaries for the Genetic Consequences
of Assortative Mating for Psychiatric Traits.” JAMA Psychiatry, vol. 73,
no. 11, American Medical Association, 2016, pp. 1189–95, doi:10.1001/jamapsychiatry.2016.2566.
short: W.J. Peyrot, M.R. Robinson, B.W.J.H. Penninx, N.R. Wray, JAMA Psychiatry
73 (2016) 1189–1195.
date_created: 2020-04-30T10:48:41Z
date_published: 2016-11-01T00:00:00Z
date_updated: 2021-01-12T08:15:11Z
day: '01'
doi: 10.1001/jamapsychiatry.2016.2566
extern: '1'
intvolume: ' 73'
issue: '11'
language:
- iso: eng
month: '11'
oa_version: None
page: 1189-1195
publication: JAMA Psychiatry
publication_identifier:
issn:
- 2168-622X
publication_status: published
publisher: American Medical Association
quality_controlled: '1'
status: public
title: Exploring boundaries for the genetic consequences of assortative mating for
psychiatric traits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 73
year: '2016'
...
---
_id: '1253'
abstract:
- lang: eng
text: This article provides an introduction to the role of microRNAs in the nervous
system and outlines their potential involvement in the pathophysiology of schizophrenia,
which is hypothesized to arise owing to environmental factors and genetic predisposition.
article_processing_charge: No
author:
- first_name: Lihuei
full_name: Tsai, Lihuei
last_name: Tsai
- first_name: Sandra
full_name: Siegert, Sandra
id: 36ACD32E-F248-11E8-B48F-1D18A9856A87
last_name: Siegert
orcid: 0000-0001-8635-0877
citation:
ama: Tsai L, Siegert S. How MicroRNAs Are involved in splitting the mind. JAMA
Psychiatry. 2016;73(4):409-410. doi:10.1001/jamapsychiatry.2015.3144
apa: Tsai, L., & Siegert, S. (2016). How MicroRNAs Are involved in splitting
the mind. JAMA Psychiatry. American Medical Association. https://doi.org/10.1001/jamapsychiatry.2015.3144
chicago: Tsai, Lihuei, and Sandra Siegert. “How MicroRNAs Are Involved in Splitting
the Mind.” JAMA Psychiatry. American Medical Association, 2016. https://doi.org/10.1001/jamapsychiatry.2015.3144.
ieee: L. Tsai and S. Siegert, “How MicroRNAs Are involved in splitting the mind,”
JAMA Psychiatry, vol. 73, no. 4. American Medical Association, pp. 409–410,
2016.
ista: Tsai L, Siegert S. 2016. How MicroRNAs Are involved in splitting the mind.
JAMA Psychiatry. 73(4), 409–410.
mla: Tsai, Lihuei, and Sandra Siegert. “How MicroRNAs Are Involved in Splitting
the Mind.” JAMA Psychiatry, vol. 73, no. 4, American Medical Association,
2016, pp. 409–10, doi:10.1001/jamapsychiatry.2015.3144.
short: L. Tsai, S. Siegert, JAMA Psychiatry 73 (2016) 409–410.
date_created: 2018-12-11T11:50:58Z
date_published: 2016-04-01T00:00:00Z
date_updated: 2024-02-14T12:07:22Z
day: '01'
ddc:
- '576'
- '610'
department:
- _id: SaSi
doi: 10.1001/jamapsychiatry.2015.3144
external_id:
pmid:
- '26963490'
file:
- access_level: open_access
checksum: 649aee381f30f7ef7e9efa912d41c2e3
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:17:24Z
date_updated: 2020-07-14T12:44:41Z
file_id: '5278'
file_name: IST-2018-981-v1+1_YNP150011_annotatedproof_FINAL.pdf
file_size: 601679
relation: main_file
file_date_updated: 2020-07-14T12:44:41Z
has_accepted_license: '1'
intvolume: ' 73'
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Submitted Version
page: 409 - 410
pmid: 1
publication: JAMA Psychiatry
publication_identifier:
issn:
- 2168-622X
publication_status: published
publisher: American Medical Association
publist_id: '6074'
pubrep_id: '981'
quality_controlled: '1'
scopus_import: '1'
status: public
title: How MicroRNAs Are involved in splitting the mind
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 73
year: '2016'
...