---
_id: '8229'
abstract:
- lang: eng
  text: Food proteins may get nitrated by various exogenous or endogenous mechanisms.
    As individuals might get recurrently exposed to nitrated proteins via daily diet,
    we aimed to investigate the effect of repeatedly ingested nitrated food proteins
    on the subsequent immune response in non-allergic and allergic mice using the
    milk allergen beta-lactoglobulin (BLG) as model food protein in a mouse model.
    Evaluating the presence of nitrated proteins in food, we could detect 3-nitrotyrosine
    (3-NT) in extracts of different foods and in stomach content extracts of non-allergic
    mice under physiological conditions. Chemically nitrated BLG (BLGn) exhibited
    enhanced susceptibility to degradation in simulated gastric fluid experiments
    compared to untreated BLG (BLGu). Gavage of BLGn to non-allergic animals increased
    interferon-γ and interleukin-10 release of stimulated spleen cells and led to
    the formation of BLG-specific serum IgA. Allergic mice receiving three oral gavages
    of BLGn had higher levels of mouse mast cell protease-1 (mMCP-1) compared to allergic
    mice receiving BLGu. Regardless of the preceding immune status, non-allergic or
    allergic, repeatedly ingested nitrated food proteins seem to considerably influence
    the subsequent immune response.
article_number: '2463'
article_processing_charge: No
article_type: original
author:
- first_name: Anna S.
  full_name: Ondracek, Anna S.
  last_name: Ondracek
  orcid: 0000-0001-7625-3651
- first_name: Denise
  full_name: Heiden, Denise
  last_name: Heiden
- first_name: Gertie J.
  full_name: Oostingh, Gertie J.
  last_name: Oostingh
- first_name: Elisabeth
  full_name: Fuerst, Elisabeth
  last_name: Fuerst
- first_name: Judit
  full_name: Fazekas-Singer, Judit
  id: 36432834-F248-11E8-B48F-1D18A9856A87
  last_name: Fazekas-Singer
  orcid: 0000-0002-8777-3502
- first_name: Cornelia
  full_name: Bergmayr, Cornelia
  last_name: Bergmayr
- first_name: Johanna
  full_name: Rohrhofer, Johanna
  last_name: Rohrhofer
  orcid: 0000-0002-2783-2099
- first_name: Erika
  full_name: Jensen-Jarolim, Erika
  last_name: Jensen-Jarolim
  orcid: 0000-0003-4019-5765
- first_name: Albert
  full_name: Duschl, Albert
  last_name: Duschl
  orcid: 0000-0002-7034-9860
- first_name: Eva
  full_name: Untersmayr, Eva
  last_name: Untersmayr
  orcid: 0000-0002-1963-499X
citation:
  ama: Ondracek AS, Heiden D, Oostingh GJ, et al. Immune effects of the nitrated food
    allergen beta-lactoglobulin in an experimental food allergy model. <i>Nutrients</i>.
    2019;11(10). doi:<a href="https://doi.org/10.3390/nu11102463">10.3390/nu11102463</a>
  apa: Ondracek, A. S., Heiden, D., Oostingh, G. J., Fuerst, E., Singer, J., Bergmayr,
    C., … Untersmayr, E. (2019). Immune effects of the nitrated food allergen beta-lactoglobulin
    in an experimental food allergy model. <i>Nutrients</i>. MDPI. <a href="https://doi.org/10.3390/nu11102463">https://doi.org/10.3390/nu11102463</a>
  chicago: Ondracek, Anna S., Denise Heiden, Gertie J. Oostingh, Elisabeth Fuerst,
    Judit Singer, Cornelia Bergmayr, Johanna Rohrhofer, Erika Jensen-Jarolim, Albert
    Duschl, and Eva Untersmayr. “Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin
    in an Experimental Food Allergy Model.” <i>Nutrients</i>. MDPI, 2019. <a href="https://doi.org/10.3390/nu11102463">https://doi.org/10.3390/nu11102463</a>.
  ieee: A. S. Ondracek <i>et al.</i>, “Immune effects of the nitrated food allergen
    beta-lactoglobulin in an experimental food allergy model,” <i>Nutrients</i>, vol.
    11, no. 10. MDPI, 2019.
  ista: Ondracek AS, Heiden D, Oostingh GJ, Fuerst E, Singer J, Bergmayr C, Rohrhofer
    J, Jensen-Jarolim E, Duschl A, Untersmayr E. 2019. Immune effects of the nitrated
    food allergen beta-lactoglobulin in an experimental food allergy model. Nutrients.
    11(10), 2463.
  mla: Ondracek, Anna S., et al. “Immune Effects of the Nitrated Food Allergen Beta-Lactoglobulin
    in an Experimental Food Allergy Model.” <i>Nutrients</i>, vol. 11, no. 10, 2463,
    MDPI, 2019, doi:<a href="https://doi.org/10.3390/nu11102463">10.3390/nu11102463</a>.
  short: A.S. Ondracek, D. Heiden, G.J. Oostingh, E. Fuerst, J. Singer, C. Bergmayr,
    J. Rohrhofer, E. Jensen-Jarolim, A. Duschl, E. Untersmayr, Nutrients 11 (2019).
date_created: 2020-08-10T11:51:04Z
date_published: 2019-10-15T00:00:00Z
date_updated: 2021-01-12T08:17:36Z
day: '15'
doi: 10.3390/nu11102463
extern: '1'
intvolume: '        11'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.3390/nu11102463
month: '10'
oa: 1
oa_version: Published Version
publication: Nutrients
publication_identifier:
  issn:
  - 2072-6643
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: Immune effects of the nitrated food allergen beta-lactoglobulin in an experimental
  food allergy model
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2019'
...