---
_id: '10103'
abstract:
- lang: eng
  text: The small cellular molecule inositol hexakisphosphate (IP6) has been known
    for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like
    particles. However, the molecular details underlying this effect have been determined
    only recently, with the identification of the IP6 binding site in the immature
    Gag lattice. IP6 also promotes formation of the mature capsid protein (CA) lattice
    via a second IP6 binding site, and enhances core stability, creating a favorable
    environment for reverse transcription. IP6 also enhances assembly of other retroviruses,
    from both the Lentivirus and the Alpharetrovirus genera. These findings suggest
    that IP6 may have a conserved function throughout the family Retroviridae. Here,
    we discuss the different steps in the viral life cycle that are influenced by
    IP6, and describe in detail how IP6 interacts with the immature and mature lattices
    of different retroviruses.
acknowledgement: We thank Volker M. Vogt for his critical comments in preparation
  of the review.
article_number: '1853'
article_processing_charge: Yes
article_type: original
author:
- first_name: Martin
  full_name: Obr, Martin
  id: 4741CA5A-F248-11E8-B48F-1D18A9856A87
  last_name: Obr
  orcid: 0000-0003-1756-6564
- first_name: Florian KM
  full_name: Schur, Florian KM
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
- first_name: Robert A.
  full_name: Dick, Robert A.
  last_name: Dick
citation:
  ama: Obr M, Schur FK, Dick RA. A structural perspective of the role of IP6 in immature
    and mature retroviral assembly. <i>Viruses</i>. 2021;13(9). doi:<a href="https://doi.org/10.3390/v13091853">10.3390/v13091853</a>
  apa: Obr, M., Schur, F. K., &#38; Dick, R. A. (2021). A structural perspective of
    the role of IP6 in immature and mature retroviral assembly. <i>Viruses</i>. MDPI.
    <a href="https://doi.org/10.3390/v13091853">https://doi.org/10.3390/v13091853</a>
  chicago: Obr, Martin, Florian KM Schur, and Robert A. Dick. “A Structural Perspective
    of the Role of IP6 in Immature and Mature Retroviral Assembly.” <i>Viruses</i>.
    MDPI, 2021. <a href="https://doi.org/10.3390/v13091853">https://doi.org/10.3390/v13091853</a>.
  ieee: M. Obr, F. K. Schur, and R. A. Dick, “A structural perspective of the role
    of IP6 in immature and mature retroviral assembly,” <i>Viruses</i>, vol. 13, no.
    9. MDPI, 2021.
  ista: Obr M, Schur FK, Dick RA. 2021. A structural perspective of the role of IP6
    in immature and mature retroviral assembly. Viruses. 13(9), 1853.
  mla: Obr, Martin, et al. “A Structural Perspective of the Role of IP6 in Immature
    and Mature Retroviral Assembly.” <i>Viruses</i>, vol. 13, no. 9, 1853, MDPI, 2021,
    doi:<a href="https://doi.org/10.3390/v13091853">10.3390/v13091853</a>.
  short: M. Obr, F.K. Schur, R.A. Dick, Viruses 13 (2021).
date_created: 2021-10-07T09:13:29Z
date_published: 2021-09-17T00:00:00Z
date_updated: 2023-08-14T07:21:51Z
day: '17'
ddc:
- '616'
department:
- _id: FlSc
doi: 10.3390/v13091853
external_id:
  isi:
  - '000699841100001'
  pmid:
  - '34578434'
file:
- access_level: open_access
  checksum: bcfd72a12977d48e22df3d0cc55aacf1
  content_type: application/pdf
  creator: cchlebak
  date_created: 2021-10-08T10:38:15Z
  date_updated: 2021-10-08T10:38:15Z
  file_id: '10115'
  file_name: 2021_Viruses_Obr.pdf
  file_size: 4146796
  relation: main_file
  success: 1
file_date_updated: 2021-10-08T10:38:15Z
has_accepted_license: '1'
intvolume: '        13'
isi: 1
issue: '9'
keyword:
- virology
- infectious diseases
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26736D6A-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P31445
  name: Structural conservation and diversity in retroviral capsid
publication: Viruses
publication_identifier:
  issn:
  - 1999-4915
publication_status: published
publisher: MDPI
quality_controlled: '1'
status: public
title: A structural perspective of the role of IP6 in immature and mature retroviral
  assembly
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2021'
...