---
_id: '14742'
abstract:
- lang: eng
  text: "Chromosomal rearrangements (CRs) have been known since almost the beginning
    of genetics.\r\nWhile an important role for CRs in speciation has been suggested,
    evidence primarily stems\r\nfrom theoretical and empirical studies focusing on
    the microevolutionary level (i.e., on taxon\r\npairs where speciation is often
    incomplete). Although the role of CRs in eukaryotic speciation at\r\na macroevolutionary
    level has been supported by associations between species diversity and\r\nrates
    of evolution of CRs across phylogenies, these findings are limited to a restricted
    range of\r\nCRs and taxa. Now that more broadly applicable and precise CR detection
    approaches have\r\nbecome available, we address the challenges in filling some
    of the conceptual and empirical\r\ngaps between micro- and macroevolutionary studies
    on the role of CRs in speciation. We\r\nsynthesize what is known about the macroevolutionary
    impact of CRs and suggest new research avenues to overcome the pitfalls of previous
    studies to gain a more comprehensive understanding of the evolutionary significance
    of CRs in speciation across the tree of life."
acknowledgement: "K.L. was funded by a Swiss National Science Foundation Eccellenza
  project: The evolution of strong reproductive barriers towards the completion of
  speciation (PCEFP3_202869). R.F.\r\nwas funded by an FCT CEEC (Fundação para a Ciênca
  e a Tecnologia, Concurso Estímulo ao\r\nEmprego Científico) contract (2020.00275.
  CEECIND) and by an FCT research project\r\n(PTDC/BIA-EVL/1614/2021). M.R. was funded
  by the Swedish Research Council Vetenskapsrådet (grant number 2021-05243). A.M.W.
  was partly funded by the Norwegian Research Council RCN. We thank Luis Silva for
  his help preparing Figure 1. We are grateful to Maren Wellenreuther, Daniel Bolnick,
  and two anonymous reviewers for their constructive feedback on an earlier version
  of this paper."
article_number: a041447
article_processing_charge: No
article_type: original
author:
- first_name: Kay
  full_name: Lucek, Kay
  last_name: Lucek
- first_name: Mabel D.
  full_name: Giménez, Mabel D.
  last_name: Giménez
- first_name: Mathieu
  full_name: Joron, Mathieu
  last_name: Joron
- first_name: Marina
  full_name: Rafajlović, Marina
  last_name: Rafajlović
- first_name: Jeremy B.
  full_name: Searle, Jeremy B.
  last_name: Searle
- first_name: Nora
  full_name: Walden, Nora
  last_name: Walden
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Rui
  full_name: Faria, Rui
  last_name: Faria
citation:
  ama: 'Lucek K, Giménez MD, Joron M, et al. The impact of chromosomal rearrangements
    in speciation: From micro- to macroevolution. <i>Cold Spring Harbor Perspectives
    in Biology</i>. 2023;15(11). doi:<a href="https://doi.org/10.1101/cshperspect.a041447">10.1101/cshperspect.a041447</a>'
  apa: 'Lucek, K., Giménez, M. D., Joron, M., Rafajlović, M., Searle, J. B., Walden,
    N., … Faria, R. (2023). The impact of chromosomal rearrangements in speciation:
    From micro- to macroevolution. <i>Cold Spring Harbor Perspectives in Biology</i>.
    Cold Spring Harbor Laboratory. <a href="https://doi.org/10.1101/cshperspect.a041447">https://doi.org/10.1101/cshperspect.a041447</a>'
  chicago: 'Lucek, Kay, Mabel D. Giménez, Mathieu Joron, Marina Rafajlović, Jeremy
    B. Searle, Nora Walden, Anja M Westram, and Rui Faria. “The Impact of Chromosomal
    Rearrangements in Speciation: From Micro- to Macroevolution.” <i>Cold Spring Harbor
    Perspectives in Biology</i>. Cold Spring Harbor Laboratory, 2023. <a href="https://doi.org/10.1101/cshperspect.a041447">https://doi.org/10.1101/cshperspect.a041447</a>.'
  ieee: 'K. Lucek <i>et al.</i>, “The impact of chromosomal rearrangements in speciation:
    From micro- to macroevolution,” <i>Cold Spring Harbor Perspectives in Biology</i>,
    vol. 15, no. 11. Cold Spring Harbor Laboratory, 2023.'
  ista: 'Lucek K, Giménez MD, Joron M, Rafajlović M, Searle JB, Walden N, Westram
    AM, Faria R. 2023. The impact of chromosomal rearrangements in speciation: From
    micro- to macroevolution. Cold Spring Harbor Perspectives in Biology. 15(11),
    a041447.'
  mla: 'Lucek, Kay, et al. “The Impact of Chromosomal Rearrangements in Speciation:
    From Micro- to Macroevolution.” <i>Cold Spring Harbor Perspectives in Biology</i>,
    vol. 15, no. 11, a041447, Cold Spring Harbor Laboratory, 2023, doi:<a href="https://doi.org/10.1101/cshperspect.a041447">10.1101/cshperspect.a041447</a>.'
  short: K. Lucek, M.D. Giménez, M. Joron, M. Rafajlović, J.B. Searle, N. Walden,
    A.M. Westram, R. Faria, Cold Spring Harbor Perspectives in Biology 15 (2023).
date_created: 2024-01-08T12:43:48Z
date_published: 2023-11-01T00:00:00Z
date_updated: 2024-01-08T12:52:29Z
day: '01'
department:
- _id: NiBa
- _id: BeVi
doi: 10.1101/cshperspect.a041447
external_id:
  pmid:
  - '37604585'
intvolume: '        15'
issue: '11'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/cshperspect.a041447
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cold Spring Harbor Perspectives in Biology
publication_identifier:
  issn:
  - 1943-0264
publication_status: published
publisher: Cold Spring Harbor Laboratory
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The impact of chromosomal rearrangements in speciation: From micro- to macroevolution'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2023'
...
---
_id: '10016'
abstract:
- lang: eng
  text: 'Auxin has always been at the forefront of research in plant physiology and
    development. Since the earliest contemplations by Julius von Sachs and Charles
    Darwin, more than a century-long struggle has been waged to understand its function.
    This largely reflects the failures, successes, and inevitable progress in the
    entire field of plant signaling and development. Here I present 14 stations on
    our long and sometimes mystical journey to understand auxin. These highlights
    were selected to give a flavor of the field and to show the scope and limits of
    our current knowledge. A special focus is put on features that make auxin unique
    among phytohormones, such as its dynamic, directional transport network, which
    integrates external and internal signals, including self-organizing feedback.
    Accented are persistent mysteries and controversies. The unexpected discoveries
    related to rapid auxin responses and growth regulation recently disturbed our
    contentment regarding understanding of the auxin signaling mechanism. These new
    revelations, along with advances in technology, usher us into a new, exciting
    era in auxin research. '
acknowledgement: "The author thanks the whole community of researchers consciously
  or unconsciously working on questions related to auxin, whose hard work and enthusiasm
  contributed to development of this exciting story. Particular thanks go to many\r\nbrilliant
  present and past members of the Friml group and our numerous excellent collaborators,
  without whom my own personal journey would not be possible. The way of the cross
  with its 14 stations is a popular devotion among Roman Catholics and inspires them
  to make a spiritual pilgrimage through contemplation of Christ on his last day.
  Its aspects of gradual progress, struggle, passion, and revelation served as an
  inspiration for the formal depiction of our journey to understanding auxin as described
  in this review. It is in no way intended to reflect the personal beliefs of the
  author and readers. I am grateful to Nick Barton, Eva Benková, Lenka Caisová, Matyáš
  Fendrych, Lukáš Fiedler, Monika Frátriková, Jarmila Frimlová, Michelle Gallei, Jakub
  Hajný, Lukas Hoermayer, Alexandra Mally, Ondrˇej Novák, Jan Petrášek, Aleš Pěnčík,
  Steffen Vanneste, Tongda Xu, and Zhenbiao Yang for their valuable comments. Special
  thanks go to Michelle Gallei for her invaluable assistance with the figures."
article_number: a039859
article_processing_charge: No
article_type: review
author:
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
citation:
  ama: Friml J. Fourteen stations of auxin. <i>Cold Spring Harbor Perspectives in
    Biology</i>. 2022;14(5). doi:<a href="https://doi.org/10.1101/cshperspect.a039859
    ">10.1101/cshperspect.a039859 </a>
  apa: Friml, J. (2022). Fourteen stations of auxin. <i>Cold Spring Harbor Perspectives
    in Biology</i>. Cold Spring Harbor Laboratory. <a href="https://doi.org/10.1101/cshperspect.a039859
    ">https://doi.org/10.1101/cshperspect.a039859 </a>
  chicago: Friml, Jiří. “Fourteen Stations of Auxin.” <i>Cold Spring Harbor Perspectives
    in Biology</i>. Cold Spring Harbor Laboratory, 2022. <a href="https://doi.org/10.1101/cshperspect.a039859
    ">https://doi.org/10.1101/cshperspect.a039859 </a>.
  ieee: J. Friml, “Fourteen stations of auxin,” <i>Cold Spring Harbor Perspectives
    in Biology</i>, vol. 14, no. 5. Cold Spring Harbor Laboratory, 2022.
  ista: Friml J. 2022. Fourteen stations of auxin. Cold Spring Harbor Perspectives
    in Biology. 14(5), a039859.
  mla: Friml, Jiří. “Fourteen Stations of Auxin.” <i>Cold Spring Harbor Perspectives
    in Biology</i>, vol. 14, no. 5, a039859, Cold Spring Harbor Laboratory, 2022,
    doi:<a href="https://doi.org/10.1101/cshperspect.a039859 ">10.1101/cshperspect.a039859
    </a>.
  short: J. Friml, Cold Spring Harbor Perspectives in Biology 14 (2022).
date_created: 2021-09-14T11:36:53Z
date_published: 2022-05-27T00:00:00Z
date_updated: 2023-08-02T06:54:42Z
day: '27'
department:
- _id: JiFr
doi: '10.1101/cshperspect.a039859 '
external_id:
  isi:
  - '000806563000003'
  pmid:
  - '34400554'
intvolume: '        14'
isi: 1
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: 'https://doi.org/10.1101/cshperspect.a039859 '
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Cold Spring Harbor Perspectives in Biology
publication_identifier:
  issn:
  - 1943-0264
publication_status: published
publisher: Cold Spring Harbor Laboratory
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fourteen stations of auxin
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 14
year: '2022'
...
---
_id: '9212'
abstract:
- lang: eng
  text: Plant fitness is largely dependent on the root, the underground organ, which,
    besides its anchoring function, supplies the plant body with water and all nutrients
    necessary for growth and development. To exploit the soil effectively, roots must
    constantly integrate environmental signals and react through adjustment of growth
    and development. Important components of the root management strategy involve
    a rapid modulation of the root growth kinetics and growth direction, as well as
    an increase of the root system radius through formation of lateral roots (LRs).
    At the molecular level, such a fascinating growth and developmental flexibility
    of root organ requires regulatory networks that guarantee stability of the developmental
    program but also allows integration of various environmental inputs. The plant
    hormone auxin is one of the principal endogenous regulators of root system architecture
    by controlling primary root growth and formation of LR. In this review, we discuss
    recent progress in understanding molecular networks where auxin is one of the
    main players shaping the root system and acting as mediator between endogenous
    cues and environmental factors.
acknowledgement: We apologize to all the authors whose scientific work could not be
  cited and discussed because of space restrictions. We thank Dr. Inge Verstraeten
  (ISTAustria) and Dr. Juan Carlos Montesinos-Lopez (ETH Zürich) for helpful suggestions.
  This work was supported by the DOC Fellowship Programme of the Austrian Academy
  of Sciences (25008) to C.A.
article_number: a039941
article_processing_charge: No
article_type: original
author:
- first_name: Nicola
  full_name: Cavallari, Nicola
  id: 457160E6-F248-11E8-B48F-1D18A9856A87
  last_name: Cavallari
- first_name: Christina
  full_name: Artner, Christina
  id: 45DF286A-F248-11E8-B48F-1D18A9856A87
  last_name: Artner
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
citation:
  ama: Cavallari N, Artner C, Benková E. Auxin-regulated lateral root organogenesis.
    <i>Cold Spring Harbor Perspectives in Biology</i>. 2021;13(7). doi:<a href="https://doi.org/10.1101/cshperspect.a039941">10.1101/cshperspect.a039941</a>
  apa: Cavallari, N., Artner, C., &#38; Benková, E. (2021). Auxin-regulated lateral
    root organogenesis. <i>Cold Spring Harbor Perspectives in Biology</i>. Cold Spring
    Harbor Laboratory Press. <a href="https://doi.org/10.1101/cshperspect.a039941">https://doi.org/10.1101/cshperspect.a039941</a>
  chicago: Cavallari, Nicola, Christina Artner, and Eva Benková. “Auxin-Regulated
    Lateral Root Organogenesis.” <i>Cold Spring Harbor Perspectives in Biology</i>.
    Cold Spring Harbor Laboratory Press, 2021. <a href="https://doi.org/10.1101/cshperspect.a039941">https://doi.org/10.1101/cshperspect.a039941</a>.
  ieee: N. Cavallari, C. Artner, and E. Benková, “Auxin-regulated lateral root organogenesis,”
    <i>Cold Spring Harbor Perspectives in Biology</i>, vol. 13, no. 7. Cold Spring
    Harbor Laboratory Press, 2021.
  ista: Cavallari N, Artner C, Benková E. 2021. Auxin-regulated lateral root organogenesis.
    Cold Spring Harbor Perspectives in Biology. 13(7), a039941.
  mla: Cavallari, Nicola, et al. “Auxin-Regulated Lateral Root Organogenesis.” <i>Cold
    Spring Harbor Perspectives in Biology</i>, vol. 13, no. 7, a039941, Cold Spring
    Harbor Laboratory Press, 2021, doi:<a href="https://doi.org/10.1101/cshperspect.a039941">10.1101/cshperspect.a039941</a>.
  short: N. Cavallari, C. Artner, E. Benková, Cold Spring Harbor Perspectives in Biology
    13 (2021).
date_created: 2021-03-01T10:08:32Z
date_published: 2021-07-01T00:00:00Z
date_updated: 2023-09-27T06:44:06Z
day: '01'
department:
- _id: EvBe
doi: 10.1101/cshperspect.a039941
external_id:
  isi:
  - '000692069100001'
  pmid:
  - '33558367'
intvolume: '        13'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/cshperspect.a039941
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 2685A872-B435-11E9-9278-68D0E5697425
  name: Hormonal regulation of plant adaptive responses to environmental signals
publication: Cold Spring Harbor Perspectives in Biology
publication_identifier:
  issn:
  - 1943-0264
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Auxin-regulated lateral root organogenesis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2021'
...
---
_id: '11097'
abstract:
- lang: eng
  text: The nuclear envelope (NE) is a highly regulated membrane barrier that separates
    the nucleus from the cytoplasm in eukaryotic cells. It contains a large number
    of different proteins that have been implicated in chromatin organization and
    gene regulation. Although the nuclear membrane enables complex levels of gene
    expression, it also poses a challenge when it comes to cell division. To allow
    access of the mitotic spindle to chromatin, the nucleus of metazoans must completely
    disassemble during mitosis, generating the need to re-establish the nuclear compartment
    at the end of each cell division. Here, I summarize our current understanding
    of the dynamic remodeling of the NE during the cell cycle.
article_processing_charge: No
article_type: original
author:
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: Hetzer M. The nuclear envelope. <i>Cold Spring Harbor Perspectives in Biology</i>.
    2010;2(3):a000539-a000539. doi:<a href="https://doi.org/10.1101/cshperspect.a000539">10.1101/cshperspect.a000539</a>
  apa: Hetzer, M. (2010). The nuclear envelope. <i>Cold Spring Harbor Perspectives
    in Biology</i>. Cold Spring Harbor Laboratory. <a href="https://doi.org/10.1101/cshperspect.a000539">https://doi.org/10.1101/cshperspect.a000539</a>
  chicago: Hetzer, Martin. “The Nuclear Envelope.” <i>Cold Spring Harbor Perspectives
    in Biology</i>. Cold Spring Harbor Laboratory, 2010. <a href="https://doi.org/10.1101/cshperspect.a000539">https://doi.org/10.1101/cshperspect.a000539</a>.
  ieee: M. Hetzer, “The nuclear envelope,” <i>Cold Spring Harbor Perspectives in Biology</i>,
    vol. 2, no. 3. Cold Spring Harbor Laboratory, pp. a000539–a000539, 2010.
  ista: Hetzer M. 2010. The nuclear envelope. Cold Spring Harbor Perspectives in Biology.
    2(3), a000539–a000539.
  mla: Hetzer, Martin. “The Nuclear Envelope.” <i>Cold Spring Harbor Perspectives
    in Biology</i>, vol. 2, no. 3, Cold Spring Harbor Laboratory, 2010, pp. a000539–a000539,
    doi:<a href="https://doi.org/10.1101/cshperspect.a000539">10.1101/cshperspect.a000539</a>.
  short: M. Hetzer, Cold Spring Harbor Perspectives in Biology 2 (2010) a000539–a000539.
date_created: 2022-04-07T07:52:49Z
date_published: 2010-02-03T00:00:00Z
date_updated: 2022-07-18T08:53:50Z
day: '03'
doi: 10.1101/cshperspect.a000539
extern: '1'
external_id:
  pmid:
  - '20300205'
intvolume: '         2'
issue: '3'
keyword:
- General Biochemistry
- Genetics and Molecular Biology
language:
- iso: eng
month: '02'
oa_version: None
page: a000539-a000539
pmid: 1
publication: Cold Spring Harbor Perspectives in Biology
publication_identifier:
  issn:
  - 1943-0264
publication_status: published
publisher: Cold Spring Harbor Laboratory
quality_controlled: '1'
scopus_import: '1'
status: public
title: The nuclear envelope
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 2
year: '2010'
...