---
_id: '8228'
abstract:
- lang: eng
  text: "Background: Atopics have a lower risk for malignancies, and IgE targeted
    to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or
    adaptive immune surveillance can confer protection against tumors remains unclear.\r\nObjective:
    We aimed to investigate the effects of active and passive immunotherapy to the
    tumor-associated antigen HER-2 in three murine models differing in Epsilon-B-cell-receptor
    expression affecting the levels of expressed IgE.\r\nMethods: We compared the
    levels of several serum specific anti-HER-2 antibodies (IgE, IgG1, IgG2a, IgG2b,
    IgA) and the survival rates in low-IgE ΔM1M2 mice lacking the transmembrane/cytoplasmic
    domain of Epsilon-B-cell-receptors expressing reduced IgE levels, high-IgE KN1
    mice expressing chimeric Epsilon-Gamma1-B-cell receptors with 4-6-fold elevated
    serum IgE levels, and wild type (WT) BALB/c. Prior engrafting mice with D2F2/E2
    mammary tumors overexpressing HER-2, mice were vaccinated with HER-2 or vehicle
    control PBS using the Th2-adjuvant Al(OH)3 (active immunotherapy), or treated
    with the murine anti-HER-2 IgG1 antibody 4D5 (passive immunotherapy).\r\nResults:
    Overall, among the three strains of mice, HER-2 vaccination induced significantly
    higher levels of HER-2 specific IgE and IgG1 in high-IgE KN1, while low-IgE ΔM1M2
    mice had higher IgG2a levels. HER-2 vaccination and passive immunotherapy prolonged
    the survival in tumor-grafted WT and low-IgE ΔM1M2 strains compared with treatment
    controls; active vaccination provided the highest benefit. Notably, untreated
    high-IgE KN1 mice displayed the longest survival of all strains, which could not
    be further extended by active or passive immunotherapy.\r\nConclusion: Active
    and passive immunotherapies prolong survival in wild type and low-IgE ΔM1M2 mice
    engrafted with mammary tumors. High-IgE KN1 mice have an innate survival benefit
    following tumor challenge."
article_number: '100044'
article_processing_charge: No
article_type: original
author:
- first_name: Josef
  full_name: Singer, Josef
  last_name: Singer
  orcid: 0000-0002-8701-2412
- first_name: Gertrude
  full_name: Achatz-Straussberger, Gertrude
  last_name: Achatz-Straussberger
- first_name: Anna
  full_name: Bentley-Lukschal, Anna
  last_name: Bentley-Lukschal
- first_name: Judit
  full_name: Fazekas-Singer, Judit
  id: 36432834-F248-11E8-B48F-1D18A9856A87
  last_name: Fazekas-Singer
  orcid: 0000-0002-8777-3502
- first_name: Gernot
  full_name: Achatz, Gernot
  last_name: Achatz
- first_name: Sophia N.
  full_name: Karagiannis, Sophia N.
  last_name: Karagiannis
- first_name: Erika
  full_name: Jensen-Jarolim, Erika
  last_name: Jensen-Jarolim
citation:
  ama: 'Singer J, Achatz-Straussberger G, Bentley-Lukschal A, et al. AllergoOncology:
    High innate IgE levels are decisive for the survival of cancer-bearing mice. <i>World
    Allergy Organization Journal</i>. 2019;12(7). doi:<a href="https://doi.org/10.1016/j.waojou.2019.100044">10.1016/j.waojou.2019.100044</a>'
  apa: 'Singer, J., Achatz-Straussberger, G., Bentley-Lukschal, A., Singer, J., Achatz,
    G., Karagiannis, S. N., &#38; Jensen-Jarolim, E. (2019). AllergoOncology: High
    innate IgE levels are decisive for the survival of cancer-bearing mice. <i>World
    Allergy Organization Journal</i>. Elsevier. <a href="https://doi.org/10.1016/j.waojou.2019.100044">https://doi.org/10.1016/j.waojou.2019.100044</a>'
  chicago: 'Singer, Josef, Gertrude Achatz-Straussberger, Anna Bentley-Lukschal, Judit
    Singer, Gernot Achatz, Sophia N. Karagiannis, and Erika Jensen-Jarolim. “AllergoOncology:
    High Innate IgE Levels Are Decisive for the Survival of Cancer-Bearing Mice.”
    <i>World Allergy Organization Journal</i>. Elsevier, 2019. <a href="https://doi.org/10.1016/j.waojou.2019.100044">https://doi.org/10.1016/j.waojou.2019.100044</a>.'
  ieee: 'J. Singer <i>et al.</i>, “AllergoOncology: High innate IgE levels are decisive
    for the survival of cancer-bearing mice,” <i>World Allergy Organization Journal</i>,
    vol. 12, no. 7. Elsevier, 2019.'
  ista: 'Singer J, Achatz-Straussberger G, Bentley-Lukschal A, Singer J, Achatz G,
    Karagiannis SN, Jensen-Jarolim E. 2019. AllergoOncology: High innate IgE levels
    are decisive for the survival of cancer-bearing mice. World Allergy Organization
    Journal. 12(7), 100044.'
  mla: 'Singer, Josef, et al. “AllergoOncology: High Innate IgE Levels Are Decisive
    for the Survival of Cancer-Bearing Mice.” <i>World Allergy Organization Journal</i>,
    vol. 12, no. 7, 100044, Elsevier, 2019, doi:<a href="https://doi.org/10.1016/j.waojou.2019.100044">10.1016/j.waojou.2019.100044</a>.'
  short: J. Singer, G. Achatz-Straussberger, A. Bentley-Lukschal, J. Singer, G. Achatz,
    S.N. Karagiannis, E. Jensen-Jarolim, World Allergy Organization Journal 12 (2019).
date_created: 2020-08-10T11:50:54Z
date_published: 2019-07-29T00:00:00Z
date_updated: 2021-01-12T08:17:36Z
day: '29'
doi: 10.1016/j.waojou.2019.100044
extern: '1'
intvolume: '        12'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1016/j.waojou.2019.100044
month: '07'
oa: 1
oa_version: Published Version
publication: World Allergy Organization Journal
publication_identifier:
  issn:
  - 1939-4551
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing
  mice'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2019'
...